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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RNF214-SIDT2 (FusionGDB2 ID:75001)

Fusion Gene Summary for RNF214-SIDT2

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF214-SIDT2
Fusion gene ID: 75001
HgeneTgene
Gene symbol

RNF214

SIDT2

Gene ID

257160

51092

Gene namering finger protein 214SID1 transmembrane family member 2
Synonyms-CGI-40
Cytomap

11q23.3

11q23.3

Type of geneprotein-codingprotein-coding
DescriptionRING finger protein 214SID1 transmembrane family member 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000300650, ENST00000530849, 
ENST00000531287, ENST00000531452, 
ENST00000524917, 		ENST00000530948, 
ENST00000532062, ENST00000324225, 
ENST00000431081, 
Fusion gene scores* DoF score7 X 5 X 6=2107 X 8 X 5=280
# samples 98
** MAII scorelog2(9/210*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF214 [Title/Abstract] AND SIDT2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRNF214(117117664)-SIDT2(117060882), # samples:2
RNF214(117117664)-SIDT2(117054790), # samples:2
Anticipated loss of major functional domain due to fusion event.RNF214-SIDT2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSIDT2

GO:0050658

RNA transport

28277980


check buttonFusion gene breakpoints across RNF214 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SIDT2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PAADTCGA-IB-7654-01ARNF214chr11

117117664

-SIDT2chr11

117060882

+
ChimerDB4PAADTCGA-IB-7654RNF214chr11

117117664

+SIDT2chr11

117060882

+
ChimerDB4UCECTCGA-B5-A3S1-01ARNF214chr11

117117664

-SIDT2chr11

117054790

+
ChimerDB4UCECTCGA-B5-A3S1-01ARNF214chr11

117117664

+SIDT2chr11

117054790

+


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Fusion Gene ORF analysis for RNF214-SIDT2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000300650ENST00000530948RNF214chr11

117117664

+SIDT2chr11

117054790

+
5CDS-3UTRENST00000530849ENST00000530948RNF214chr11

117117664

+SIDT2chr11

117054790

+
5CDS-3UTRENST00000531287ENST00000530948RNF214chr11

117117664

+SIDT2chr11

117054790

+
5CDS-3UTRENST00000531452ENST00000530948RNF214chr11

117117664

+SIDT2chr11

117054790

+
5CDS-intronENST00000300650ENST00000530948RNF214chr11

117117664

+SIDT2chr11

117060882

+
5CDS-intronENST00000300650ENST00000532062RNF214chr11

117117664

+SIDT2chr11

117060882

+
5CDS-intronENST00000300650ENST00000532062RNF214chr11

117117664

+SIDT2chr11

117054790

+
5CDS-intronENST00000530849ENST00000530948RNF214chr11

117117664

+SIDT2chr11

117060882

+
5CDS-intronENST00000530849ENST00000532062RNF214chr11

117117664

+SIDT2chr11

117060882

+
5CDS-intronENST00000530849ENST00000532062RNF214chr11

117117664

+SIDT2chr11

117054790

+
5CDS-intronENST00000531287ENST00000530948RNF214chr11

117117664

+SIDT2chr11

117060882

+
5CDS-intronENST00000531287ENST00000532062RNF214chr11

117117664

+SIDT2chr11

117060882

+
5CDS-intronENST00000531287ENST00000532062RNF214chr11

117117664

+SIDT2chr11

117054790

+
5CDS-intronENST00000531452ENST00000530948RNF214chr11

117117664

+SIDT2chr11

117060882

+
5CDS-intronENST00000531452ENST00000532062RNF214chr11

117117664

+SIDT2chr11

117060882

+
5CDS-intronENST00000531452ENST00000532062RNF214chr11

117117664

+SIDT2chr11

117054790

+
Frame-shiftENST00000300650ENST00000324225RNF214chr11

117117664

+SIDT2chr11

117054790

+
Frame-shiftENST00000300650ENST00000431081RNF214chr11

117117664

+SIDT2chr11

117054790

+
Frame-shiftENST00000530849ENST00000324225RNF214chr11

117117664

+SIDT2chr11

117054790

+
Frame-shiftENST00000530849ENST00000431081RNF214chr11

117117664

+SIDT2chr11

117054790

+
Frame-shiftENST00000531287ENST00000324225RNF214chr11

117117664

+SIDT2chr11

117054790

+
Frame-shiftENST00000531287ENST00000431081RNF214chr11

117117664

+SIDT2chr11

117054790

+
Frame-shiftENST00000531452ENST00000324225RNF214chr11

117117664

+SIDT2chr11

117054790

+
Frame-shiftENST00000531452ENST00000431081RNF214chr11

117117664

+SIDT2chr11

117054790

+
In-frameENST00000300650ENST00000324225RNF214chr11

117117664

+SIDT2chr11

117060882

+
In-frameENST00000300650ENST00000431081RNF214chr11

117117664

+SIDT2chr11

117060882

+
In-frameENST00000530849ENST00000324225RNF214chr11

117117664

+SIDT2chr11

117060882

+
In-frameENST00000530849ENST00000431081RNF214chr11

117117664

+SIDT2chr11

117060882

+
In-frameENST00000531287ENST00000324225RNF214chr11

117117664

+SIDT2chr11

117060882

+
In-frameENST00000531287ENST00000431081RNF214chr11

117117664

+SIDT2chr11

117060882

+
In-frameENST00000531452ENST00000324225RNF214chr11

117117664

+SIDT2chr11

117060882

+
In-frameENST00000531452ENST00000431081RNF214chr11

117117664

+SIDT2chr11

117060882

+
intron-3CDSENST00000524917ENST00000324225RNF214chr11

117117664

+SIDT2chr11

117060882

+
intron-3CDSENST00000524917ENST00000324225RNF214chr11

117117664

+SIDT2chr11

117054790

+
intron-3CDSENST00000524917ENST00000431081RNF214chr11

117117664

+SIDT2chr11

117060882

+
intron-3CDSENST00000524917ENST00000431081RNF214chr11

117117664

+SIDT2chr11

117054790

+
intron-3UTRENST00000524917ENST00000530948RNF214chr11

117117664

+SIDT2chr11

117054790

+
intron-intronENST00000524917ENST00000530948RNF214chr11

117117664

+SIDT2chr11

117060882

+
intron-intronENST00000524917ENST00000532062RNF214chr11

117117664

+SIDT2chr11

117060882

+
intron-intronENST00000524917ENST00000532062RNF214chr11

117117664

+SIDT2chr11

117054790

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for RNF214-SIDT2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RNF214chr11117117664+SIDT2chr11117054789+2.42E-050.9999758
RNF214chr11117117664+SIDT2chr11117060881+1.20E-101
RNF214chr11117117664+SIDT2chr11117054789+2.42E-050.9999758
RNF214chr11117117664+SIDT2chr11117060881+1.20E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RNF214-SIDT2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:117117664/chr11:117060882)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSIDT2chr11:117117664chr11:117060882ENST000003242251526764_767497833.0Compositional biasNote=Poly-Phe
TgeneSIDT2chr11:117117664chr11:117060882ENST000003242251526521_546497833.0Topological domainCytoplasmic
TgeneSIDT2chr11:117117664chr11:117060882ENST000003242251526568_605497833.0Topological domainExtracellular
TgeneSIDT2chr11:117117664chr11:117060882ENST000003242251526627_631497833.0Topological domainCytoplasmic
TgeneSIDT2chr11:117117664chr11:117060882ENST000003242251526653_688497833.0Topological domainExtracellular
TgeneSIDT2chr11:117117664chr11:117060882ENST000003242251526710_715497833.0Topological domainCytoplasmic
TgeneSIDT2chr11:117117664chr11:117060882ENST000003242251526737_746497833.0Topological domainExtracellular
TgeneSIDT2chr11:117117664chr11:117060882ENST000003242251526768_796497833.0Topological domainCytoplasmic
TgeneSIDT2chr11:117117664chr11:117060882ENST000003242251526818_832497833.0Topological domainExtracellular
TgeneSIDT2chr11:117117664chr11:117060882ENST000003242251526500_520497833.0TransmembraneHelical
TgeneSIDT2chr11:117117664chr11:117060882ENST000003242251526547_567497833.0TransmembraneHelical
TgeneSIDT2chr11:117117664chr11:117060882ENST000003242251526606_626497833.0TransmembraneHelical
TgeneSIDT2chr11:117117664chr11:117060882ENST000003242251526632_652497833.0TransmembraneHelical
TgeneSIDT2chr11:117117664chr11:117060882ENST000003242251526689_709497833.0TransmembraneHelical
TgeneSIDT2chr11:117117664chr11:117060882ENST000003242251526716_736497833.0TransmembraneHelical
TgeneSIDT2chr11:117117664chr11:117060882ENST000003242251526747_767497833.0TransmembraneHelical
TgeneSIDT2chr11:117117664chr11:117060882ENST000003242251526797_817497833.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF214chr11:117117664chr11:117060882ENST00000300650+514220_379319704.0Coiled coilOntology_term=ECO:0000255
HgeneRNF214chr11:117117664chr11:117060882ENST00000531452+615220_379319704.0Coiled coilOntology_term=ECO:0000255
HgeneRNF214chr11:117117664chr11:117060882ENST00000300650+514432_551319704.0Compositional biasNote=Pro-rich
HgeneRNF214chr11:117117664chr11:117060882ENST00000531452+615432_551319704.0Compositional biasNote=Pro-rich
HgeneRNF214chr11:117117664chr11:117060882ENST00000300650+514658_700319704.0Zinc fingerRING-type%3B atypical
HgeneRNF214chr11:117117664chr11:117060882ENST00000531452+615658_700319704.0Zinc fingerRING-type%3B atypical
TgeneSIDT2chr11:117117664chr11:117060882ENST00000324225152619_296497833.0Topological domainExtracellular
TgeneSIDT2chr11:117117664chr11:117060882ENST000003242251526318_447497833.0Topological domainCytoplasmic
TgeneSIDT2chr11:117117664chr11:117060882ENST000003242251526469_499497833.0Topological domainExtracellular
TgeneSIDT2chr11:117117664chr11:117060882ENST000003242251526297_317497833.0TransmembraneHelical
TgeneSIDT2chr11:117117664chr11:117060882ENST000003242251526448_468497833.0TransmembraneHelical


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Fusion Gene Sequence for RNF214-SIDT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for RNF214-SIDT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RNF214-SIDT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RNF214-SIDT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource