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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:RNF216-JAZF1 (FusionGDB2 ID:75012) |
Fusion Gene Summary for RNF216-JAZF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RNF216-JAZF1 | Fusion gene ID: 75012 | Hgene | Tgene | Gene symbol | RNF216 | JAZF1 | Gene ID | 54476 | 221895 |
| Gene name | ring finger protein 216 | JAZF zinc finger 1 | |
| Synonyms | CAHH|TRIAD3|U7I1|UBCE7IP1|ZIN | TIP27|ZNF802 | |
| Cytomap | 7p22.1 | 7p15.2-p15.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase RNF216RING-type E3 ubiquitin transferase RNF216triad domain-containing protein 3ubiquitin-conjugating enzyme 7-interacting protein 1zinc finger protein inhibiting NF-kappa-B | juxtaposed with another zinc finger protein 1TAK1-interacting protein 27juxtaposed with another zinc finger gene 1zinc finger protein 802 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q86VZ6 | |
| Ensembl transtripts involved in fusion gene | ENST00000389902, ENST00000425013, ENST00000469375, | ENST00000466516, ENST00000283928, | |
| Fusion gene scores | * DoF score | 12 X 13 X 9=1404 | 9 X 6 X 5=270 |
| # samples | 15 | 9 | |
| ** MAII score | log2(15/1404*10)=-3.22650852980868 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/270*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RNF216 [Title/Abstract] AND JAZF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | RNF216(5680785)-JAZF1(28031600), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RNF216 | GO:0032648 | regulation of interferon-beta production | 19893624 |
| Hgene | RNF216 | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 19893624 |
| Hgene | RNF216 | GO:0050691 | regulation of defense response to virus by host | 19893624 |
| Hgene | RNF216 | GO:0070936 | protein K48-linked ubiquitination | 19893624 |
| Tgene | JAZF1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 15302918 |
| Fusion gene breakpoints across RNF216 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across JAZF1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUAD | TCGA-69-7980-01A | RNF216 | chr7 | 5680785 | - | JAZF1 | chr7 | 28031600 | - |
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Fusion Gene ORF analysis for RNF216-JAZF1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000389902 | ENST00000466516 | RNF216 | chr7 | 5680785 | - | JAZF1 | chr7 | 28031600 | - |
| 5CDS-intron | ENST00000425013 | ENST00000466516 | RNF216 | chr7 | 5680785 | - | JAZF1 | chr7 | 28031600 | - |
| 5UTR-3CDS | ENST00000469375 | ENST00000283928 | RNF216 | chr7 | 5680785 | - | JAZF1 | chr7 | 28031600 | - |
| 5UTR-intron | ENST00000469375 | ENST00000466516 | RNF216 | chr7 | 5680785 | - | JAZF1 | chr7 | 28031600 | - |
| In-frame | ENST00000389902 | ENST00000283928 | RNF216 | chr7 | 5680785 | - | JAZF1 | chr7 | 28031600 | - |
| In-frame | ENST00000425013 | ENST00000283928 | RNF216 | chr7 | 5680785 | - | JAZF1 | chr7 | 28031600 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000425013 | RNF216 | chr7 | 5680785 | - | ENST00000283928 | JAZF1 | chr7 | 28031600 | - | 5280 | 2436 | 213 | 2456 | 747 |
| ENST00000389902 | RNF216 | chr7 | 5680785 | - | ENST00000283928 | JAZF1 | chr7 | 28031600 | - | 5494 | 2650 | 256 | 2670 | 804 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000425013 | ENST00000283928 | RNF216 | chr7 | 5680785 | - | JAZF1 | chr7 | 28031600 | - | 0.000640011 | 0.99936 |
| ENST00000389902 | ENST00000283928 | RNF216 | chr7 | 5680785 | - | JAZF1 | chr7 | 28031600 | - | 0.000633461 | 0.9993666 |
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Fusion Genomic Features for RNF216-JAZF1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for RNF216-JAZF1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:5680785/chr7:28031600) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | JAZF1 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2 (PubMed:15302918). Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (By similarity). Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (By similarity). Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (By similarity). Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (By similarity). {ECO:0000250|UniProtKB:Q80ZQ5, ECO:0000269|PubMed:15302918}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RNF216 | chr7:5680785 | chr7:28031600 | ENST00000389902 | - | 15 | 17 | 475_491 | 794 | 924.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | RNF216 | chr7:5680785 | chr7:28031600 | ENST00000389902 | - | 15 | 17 | 737_763 | 794 | 924.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | RNF216 | chr7:5680785 | chr7:28031600 | ENST00000425013 | - | 15 | 17 | 475_491 | 737 | 867.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | RNF216 | chr7:5680785 | chr7:28031600 | ENST00000389902 | - | 15 | 17 | 511_728 | 794 | 924.0 | Region | TRIAD supradomain |
| Hgene | RNF216 | chr7:5680785 | chr7:28031600 | ENST00000425013 | - | 15 | 17 | 511_728 | 737 | 867.0 | Region | TRIAD supradomain |
| Hgene | RNF216 | chr7:5680785 | chr7:28031600 | ENST00000389902 | - | 15 | 17 | 515_564 | 794 | 924.0 | Zinc finger | RING-type 1 |
| Hgene | RNF216 | chr7:5680785 | chr7:28031600 | ENST00000389902 | - | 15 | 17 | 583_648 | 794 | 924.0 | Zinc finger | IBR-type |
| Hgene | RNF216 | chr7:5680785 | chr7:28031600 | ENST00000389902 | - | 15 | 17 | 675_703 | 794 | 924.0 | Zinc finger | RING-type 2%3B atypical |
| Hgene | RNF216 | chr7:5680785 | chr7:28031600 | ENST00000425013 | - | 15 | 17 | 515_564 | 737 | 867.0 | Zinc finger | RING-type 1 |
| Hgene | RNF216 | chr7:5680785 | chr7:28031600 | ENST00000425013 | - | 15 | 17 | 583_648 | 737 | 867.0 | Zinc finger | IBR-type |
| Hgene | RNF216 | chr7:5680785 | chr7:28031600 | ENST00000425013 | - | 15 | 17 | 675_703 | 737 | 867.0 | Zinc finger | RING-type 2%3B atypical |
| Tgene | JAZF1 | chr7:5680785 | chr7:28031600 | ENST00000283928 | 0 | 5 | 173_198 | 38 | 244.0 | Zinc finger | Note=C2H2-type 2 | |
| Tgene | JAZF1 | chr7:5680785 | chr7:28031600 | ENST00000283928 | 0 | 5 | 208_230 | 38 | 244.0 | Zinc finger | Note=C2H2-type 3%3B degenerate |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RNF216 | chr7:5680785 | chr7:28031600 | ENST00000425013 | - | 15 | 17 | 737_763 | 737 | 867.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | RNF216 | chr7:5680785 | chr7:28031600 | ENST00000389902 | - | 15 | 17 | 769_862 | 794 | 924.0 | Compositional bias | Note=Pro-rich |
| Hgene | RNF216 | chr7:5680785 | chr7:28031600 | ENST00000425013 | - | 15 | 17 | 769_862 | 737 | 867.0 | Compositional bias | Note=Pro-rich |
| Tgene | JAZF1 | chr7:5680785 | chr7:28031600 | ENST00000283928 | 0 | 5 | 12_37 | 38 | 244.0 | Zinc finger | Note=C2H2-type 1 |
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Fusion Gene Sequence for RNF216-JAZF1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >75012_75012_1_RNF216-JAZF1_RNF216_chr7_5680785_ENST00000389902_JAZF1_chr7_28031600_ENST00000283928_length(transcript)=5494nt_BP=2650nt AGTACCCGGAGTGCCTCTATGGTTCTTCCTGTCCTTAGTCGGGAGGGGGCGCTGTGCGCAGGCGCGAGGTGACGCCGCGGCAGGGCCGGA AGGAGTGCAGCGGCTGCCACGGAGCTCGCAGCTGCGGCTTCTGAGGAGTAAGCGGCGCGGTAGCGAAGGCCGCCGAACCTGCCTGGCTAG CCGGCGACTTGAGTGACGATTCTTTTGAAACAGATGGTCACCATGTTTAGATATTAGCAGTCCCATATATGCATGTCTGCATTTGAAAAT GGAAGAGGGAAACAACAATGAAGAGGTAATTCACTTGAACAACTTTCACTGCCATCGGGGACAAGAGTGGATCAATCTCCGAGATGGGCC CATCACCATATCTGACTCCTCAGATGAGGAAAGGATTCCAATGCTGGTCACCCCAGCTCCTCAGCAGCATGAAGAAGAGGACCTGGATGA TGATGTCATCCTGACAGAAACAAATAAACCTCAGAGATCACGACCCAATCTCATCAAACCAGCTGCCCAGTGGCAAGATCTGAAAAGGTT GGGAGAAGAAAGGCCTAAAAAGTCTAGAGCAGCATTTGAATCAGATAAGAGCAGCTATTTTTCAGTGTGTAACAACCCATTGTTTGATTC TGGGGCACAGGATGATTCTGAGGATGACTACGGTGAATTTCTGGATCTTGGGCCTCCTGGAATCTCTGAATTCACTAAGCCAAGTGGCCA AACAGAAAGAGAACCCAAGCCTGGACCGAGTCATAACCAAGCAGCAAATGACATTGTCAACCCCAGATCAGAGCAGAAAGTCATCATCTT GGAAGAAGGTAGCCTTCTTTACACAGAAAGCGATCCTTTGGAAACTCAGAACCAGTCATCCGAAGACTCAGAGACAGAGCTGTTATCAAA TCTAGGAGAGTCAGCTGCTCTAGCAGATGATCAGGCCATCGAAGAAGACTGCTGGTTAGATCATCCTTACTTCCAGTCTCTGAACCAACA GCCCCGTGAAATAACAAACCAGGTCGTTCCTCAGGAACGGCAGCCTGAAGCAGAACTGGGCCGCTTGTTGTTTCAGCATGAATTCCCAGG GCCCGCTTTTCCAAGGCCGGAACCCCAGCAAGGTGGGATTTCAGGCCCCTCTTCTCCTCAGCCTGCCCATCCTCTAGGAGAGTTTGAAGA CCAGCAGTTAGCAAGTGATGATGAAGAGCCAGGTCCAGCCTTTCCAATGCAAGAATCTCAAGAGCCCAATTTGGAAAACATTTGGGGGCA AGAAGCTGCAGAGGTAGATCAAGAGCTCGTTGAACTACTAGTGAAAGAAACGGAAGCAAGATTTCCAGATGTAGCAAATGGGTTTATTGA GGAAATAATTCATTTTAAGAATTATTATGATCTGAATGTACTTTGTAATTTTCTTCTGGAAAACCCAGATTATCCAAAGAGAGAAGACAG AATCATTATAAATCCCAGTAGCAGTCTGCTGGCCAGCCAAGATGAGACAAAGTTGCCTAAAATAGACTTTTTTGACTATTCTAAATTGAC CCCTCTTGACCAGCGCTGCTTCATCCAAGCTGCTGACCTCCTCATGGCCGACTTCAAAGTGCTCAGTAGTCAGGACATCAAGTGGGCCCT GCACGAGCTCAAAGGACACTATGCAATCACCCGAAAGGCCTTGTCTGATGCCATTAAAAAATGGCAGGAGCTGTCACCAGAAACCAGTGG AAAAAGGAAGAAGAGAAAACAAATGAACCAGTATTCTTACATTGATTTCAAGTTTGAACAAGGTGACATAAAAATAGAAAAGAGGATGTT CTTTCTTGAAAATAAGCGACGACATTGTAGGTCCTATGACCGACGTGCTCTCCTTCCAGCTGTGCAACAAGAGCAGGAGTTCTATGAGCA GAAAATCAAAGAGATGGCAGAGCATGAAGACTTTTTGCTTGCCCTACAGATGAATGAAGAACAGTATCAAAAGGATGGCCAGCTGATTGA GTGTCGCTGCTGCTATGGGGAATTTCCATTCGAGGAGCTGACGCAGTGCGCAGATGCTCACTTGTTCTGCAAAGAGTGTCTCATCAGATA TGCCCAAGAGGCAGTCTTTGGATCTGGAAAGTTGGAGCTCAGCTGCATGGAAGGCAGCTGCACGTGTTCGTTCCCAACCAGTGAGCTGGA GAAGGTGCTCCCCCAGACCATCCTGTATAAGTACTATGAGCGAAAAGCCGAGGAGGAGGTTGCGGCAGCCTACGCCGACGAGCTTGTCAG GTGCCCGTCCTGTAGCTTTCCGGCTCTGTTGGACAGTGATGTGAAGAGGTTCAGCTGTCCTAATCCTCACTGCCGAAAGGAAACCTGTAG GAAGTGTCAGGGACTCTGGAAAGAACATAATGGCCTCACCTGTGAAGAGCTGGCTGAAAAAGACGACATCAAGTACCGTACCTCTATTGA AGAAAAAATGACTGCTGCCCGCATTAGAAAATGCCACAAGTGTGGGACTGGCCTCATCAAATCTGAAGGCTGCAACCGCATGTCTTGCCG CTGTGGTGCCCAGATGTGCTACCTCTGTCGAGTTTCTATTAATGGATATGACCATTTCTGCCAACATCCCCGCTCACCAGGAGCCCCTTG CCAGGAGTGTTCAAGATGCTCTCTCTGGACCGATCCCACTATACAGATCCACGGGTTTTAGAAAAACAAGAATTACAGCAGCCAACCTAT GTTGCCCTGAGTTACATAAATAGATTCATGACAGATGCTGCCCGCCGAGAGCAGGAGTCCCTAAAGAAGAAGATTCAGCCGAAGCTCTCG CTGACTCTGTCCAGCTCAGTGTCTCGAGGGAATGTGTCCACTCCCCCACGCCACAGCAGTGGAAGCCTTACTCCCCCCGTGACCCCACCC ATCACCCCCTCCTCTTCATTCCGCAGCAGCACTCCGACAGGCAGCGAGTATGACGAGGAGGAGGTGGACTATGAGGAGTCGGACAGCGAT GAGTCCTGGACCACAGAGAGTGCCATCAGCTCCGAAGCCATCCTCAGCTCCATGTGCATGAATGGAGGGGAAGAGAAGCCTTTTGCCTGC CCAGTTCCTGGATGTAAAAAGAGATACAAGAATGTGAATGGCATAAAGTATCACGCTAAGAATGGTCACAGAACACAGATTCGTGTCCGC AAACCATTCAAGTGTCGCTGTGGGAAGAGTTACAAGACAGCTCAGGGCCTGCGGCACCACACAATCAATTTCCATCCCCCGGTGTCGGCT GAGATTATCAGGAAGATGCAGCAATAACATGCTGGTCATAACTGTGCCAAGAAATCCTCACCAGCAGTTGCTGATTTTGAAAACAGCCAC CTTTTTTCAGGGGAAGCATTCAGCAACCCTTTAAAGAAAAAGAATTAAATGCATGCTTTAAATTTTTTCTGTAATTTTGGAATGATGTAT CTTTGTAGAGTTAATGATTTTGTACATTTGCACATGTAATCATCATACCCATTTTCATTACTTTGATATAAGGTGCTAAACAAAAAAAGC TCTAGGTTCTTCAGCACATTTCCCCCAAAACAAAATAAAATTGAGGGCATGTTGCATATTGTTGAATTGTATTGCGGTGGTATCAACCTG GGGGGAGGAGGGGCTGGCACTGAGATTTTTTTTTCAAGATTGTAATGTGATTGAAGTTTTCAACACATCAACTCACATATGTTCAAAACC AAAATAATACCTTCATTATCAAACTGGTTACCATGCCTTACATAATGGAGTTAGTATTTGTGAGTAGAAAGACTTTAGGTAATGGAAATA TAAATAAGAAAGAATGTTTAACATAATATGCTAAAAATATTTTCATATTTAAATAACATACGTAAAGGTGTGCTTTCTGTGTTTTATATT ATCTTGCAAATCCTTTTGCCCTTTAAAAAGCTGAAAATCTTGCCATCTGACTTACTAGTCATTTTAGTGTTATAAATGGCATTTTGTACA AAATAGTCTATTCAGTTCGTTCATTCATTTAACACACATTGATTGAGTGCCTGCTGGGTACAAGGGATTCAATTTATGCCTATTGATATC TGCGGACCAAGATACCCATTTAGTGAAATACTTTTTTCCCTGAAATCTGTTAGAAAAGACTTTGAAATACTTCAGTGCAAAGTGTGTGTG TGTGAAGTTTAGTTATATCTTCATCTTCAGATGAAGTTTTAAAGCACTTTGTAGTTCTCTATTGCCAACAATTTAATGTTTATGTGTTGC CAATTCTTGCAACCACTGCCCTACCAAACCTGTGGGTTGCAAATCAGAACTAAAATTCTAAGCACGTTTCAAAGATGAACACTTTTGTTA AGACCCCTATTGCCTCTTCTTCATGCTCATTTTTTACTTTTTTTAAAAGGTACTTTTCTCATCACATTGTAGAGAGGTCTGCATTCTCAT TGGAAATGTCTGTTTAGCTTTATAAAACAAACACTTTGCTGAAATAGGAAAATGAGCCTTATTGACAATTAAGTGCTTCTTGCAGCAGGT GGTCAAAGAAAAGCATGACTAATACGACCTATTAGAGTAATCTACATCTGGACCATTCCTTAAGTTTTTCCTCACCGACAGTACCATCAT GCCTTGAGTGTTCTTTTCTCCCAAGTGCTATTCCTTAAACACGAGAGTTTACCAGTTGCCTAATAATGCAATAAAAAATGCTTTGAGATA GCTAACTGCCCATAAAACAAACTCAAATTGCTTATAAAGTTTCTTCCCATGTTCCCATTTGATGAAAAGTCTTACATCACATATAACTGG GAAGCAGGGGTCCCTCCTCAATTTTCAGACATTTTGAAAGGATGACAGTTCTGTTTGTTAGATGAGTAAACCTCTATATTCATAAGTTCT AAAATCCTTCATTATGAGGGATTCAAAGTATTTATAAAAACACTGCCCTCTAAAAATTTCCTCAGATCTGAAGTATGGTCTTGGTCCTGA ATATACAGTGTTATCCTATGTTTAAAAGGGTGATCCAGACATGAGACGCAACTAGTTGGTGCATAAGAAGGCCCCACTTGGCTATTTCAT ATCTACCTACAATTGACCAAAAAAAATTTTTTAGGCCAGCAATTATTATTTAGCTTCGCTCTTTCTAGTGCAAGAAACTGCAGGCTGGAT CAGTAGTTCAACAGCTAAACAGTCATAAAATAGTCATTGTGCATGTTAAATTTCTTTCAATGCTTTCAAAGATAAATTCCAATTTCTATT TACTTATTCATTGTGACAGTATTACTAAACAGGTAAGGATGGGAATATTTTGTTATACTGTGTATAGTGAATGTATTGTACTGTGTCTGT GAAAACTGTGCTTTAAATTATATTTTCATATGTTTTGTTGGGGACAGAGCACATTAAGTCTGAAAGCAACAGAGGTTTGTTTTAGAACTG AAGGCAATTTAATCAAAATTCCTGTCAAGAAAAGCTGCTTATAAATGTAAATGAAATCACATTTAAAATAAACTGCCTCTGACCCAAAAA >75012_75012_1_RNF216-JAZF1_RNF216_chr7_5680785_ENST00000389902_JAZF1_chr7_28031600_ENST00000283928_length(amino acids)=804AA_BP= MHLKMEEGNNNEEVIHLNNFHCHRGQEWINLRDGPITISDSSDEERIPMLVTPAPQQHEEEDLDDDVILTETNKPQRSRPNLIKPAAQWQ DLKRLGEERPKKSRAAFESDKSSYFSVCNNPLFDSGAQDDSEDDYGEFLDLGPPGISEFTKPSGQTEREPKPGPSHNQAANDIVNPRSEQ KVIILEEGSLLYTESDPLETQNQSSEDSETELLSNLGESAALADDQAIEEDCWLDHPYFQSLNQQPREITNQVVPQERQPEAELGRLLFQ HEFPGPAFPRPEPQQGGISGPSSPQPAHPLGEFEDQQLASDDEEPGPAFPMQESQEPNLENIWGQEAAEVDQELVELLVKETEARFPDVA NGFIEEIIHFKNYYDLNVLCNFLLENPDYPKREDRIIINPSSSLLASQDETKLPKIDFFDYSKLTPLDQRCFIQAADLLMADFKVLSSQD IKWALHELKGHYAITRKALSDAIKKWQELSPETSGKRKKRKQMNQYSYIDFKFEQGDIKIEKRMFFLENKRRHCRSYDRRALLPAVQQEQ EFYEQKIKEMAEHEDFLLALQMNEEQYQKDGQLIECRCCYGEFPFEELTQCADAHLFCKECLIRYAQEAVFGSGKLELSCMEGSCTCSFP TSELEKVLPQTILYKYYERKAEEEVAAAYADELVRCPSCSFPALLDSDVKRFSCPNPHCRKETCRKCQGLWKEHNGLTCEELAEKDDIKY -------------------------------------------------------------- >75012_75012_2_RNF216-JAZF1_RNF216_chr7_5680785_ENST00000425013_JAZF1_chr7_28031600_ENST00000283928_length(transcript)=5280nt_BP=2436nt AGGGGGCGCTGTGCGCAGGCGCGAGGTGACGCCGCGGCAGGGCCGGAAGGAGTGCAGCGGCTGCCACGGAGCTCGCAGCTGCGGCTTCTG AGGAGTAAGCGGCGCGGTAGCGAAGGCCGCCGAACCTGCCTGGCTAGCCGGCGACTTGAGTGACGATTCTTTTGAAACAGATGGTCACCA TGTTTAGATATTAGCAGTCCCATATATGCATGTCTGCATTTGAAAATGGAAGAGGGAAACAACAATGAAGAGGTAATTCACTTGAACAAC TTTCACTGCCATCGGGGACAAGAGTGGATCAATCTCCGAGATGGGCCCATCACCATATCTGACTCCTCAGATGAGGAAAGGATTCCAATG CTGGTCACCCCAGCTCCTCAGCAGCATGAAGAAGAGGACCTGGATGATGATGTCATCCTGACAGAAGATGATTCTGAGGATGACTACGGT GAATTTCTGGATCTTGGGCCTCCTGGAATCTCTGAATTCACTAAGCCAAGTGGCCAAACAGAAAGAGAACCCAAGCCTGGACCGAGTCAT AACCAAGCAGCAAATGACATTGTCAACCCCAGATCAGAGCAGAAAGTCATCATCTTGGAAGAAGGTAGCCTTCTTTACACAGAAAGCGAT CCTTTGGAAACTCAGAACCAGTCATCCGAAGACTCAGAGACAGAGCTGTTATCAAATCTAGGAGAGTCAGCTGCTCTAGCAGATGATCAG GCCATCGAAGAAGACTGCTGGTTAGATCATCCTTACTTCCAGTCTCTGAACCAACAGCCCCGTGAAATAACAAACCAGGTCGTTCCTCAG GAACGGCAGCCTGAAGCAGAACTGGGCCGCTTGTTGTTTCAGCATGAATTCCCAGGGCCCGCTTTTCCAAGGCCGGAACCCCAGCAAGGT GGGATTTCAGGCCCCTCTTCTCCTCAGCCTGCCCATCCTCTAGGAGAGTTTGAAGACCAGCAGTTAGCAAGTGATGATGAAGAGCCAGGT CCAGCCTTTCCAATGCAAGAATCTCAAGAGCCCAATTTGGAAAACATTTGGGGGCAAGAAGCTGCAGAGGTAGATCAAGAGCTCGTTGAA CTACTAGTGAAAGAAACGGAAGCAAGATTTCCAGATGTAGCAAATGGGTTTATTGAGGAAATAATTCATTTTAAGAATTATTATGATCTG AATGTACTTTGTAATTTTCTTCTGGAAAACCCAGATTATCCAAAGAGAGAAGACAGAATCATTATAAATCCCAGTAGCAGTCTGCTGGCC AGCCAAGATGAGACAAAGTTGCCTAAAATAGACTTTTTTGACTATTCTAAATTGACCCCTCTTGACCAGCGCTGCTTCATCCAAGCTGCT GACCTCCTCATGGCCGACTTCAAAGTGCTCAGTAGTCAGGACATCAAGTGGGCCCTGCACGAGCTCAAAGGACACTATGCAATCACCCGA AAGGCCTTGTCTGATGCCATTAAAAAATGGCAGGAGCTGTCACCAGAAACCAGTGGAAAAAGGAAGAAGAGAAAACAAATGAACCAGTAT TCTTACATTGATTTCAAGTTTGAACAAGGTGACATAAAAATAGAAAAGAGGATGTTCTTTCTTGAAAATAAGCGACGACATTGTAGGTCC TATGACCGACGTGCTCTCCTTCCAGCTGTGCAACAAGAGCAGGAGTTCTATGAGCAGAAAATCAAAGAGATGGCAGAGCATGAAGACTTT TTGCTTGCCCTACAGATGAATGAAGAACAGTATCAAAAGGATGGCCAGCTGATTGAGTGTCGCTGCTGCTATGGGGAATTTCCATTCGAG GAGCTGACGCAGTGCGCAGATGCTCACTTGTTCTGCAAAGAGTGTCTCATCAGATATGCCCAAGAGGCAGTCTTTGGATCTGGAAAGTTG GAGCTCAGCTGCATGGAAGGCAGCTGCACGTGTTCGTTCCCAACCAGTGAGCTGGAGAAGGTGCTCCCCCAGACCATCCTGTATAAGTAC TATGAGCGAAAAGCCGAGGAGGAGGTTGCGGCAGCCTACGCCGACGAGCTTGTCAGGTGCCCGTCCTGTAGCTTTCCGGCTCTGTTGGAC AGTGATGTGAAGAGGTTCAGCTGTCCTAATCCTCACTGCCGAAAGGAAACCTGTAGGAAGTGTCAGGGACTCTGGAAAGAACATAATGGC CTCACCTGTGAAGAGCTGGCTGAAAAAGACGACATCAAGTACCGTACCTCTATTGAAGAAAAAATGACTGCTGCCCGCATTAGAAAATGC CACAAGTGTGGGACTGGCCTCATCAAATCTGAAGGCTGCAACCGCATGTCTTGCCGCTGTGGTGCCCAGATGTGCTACCTCTGTCGAGTT TCTATTAATGGATATGACCATTTCTGCCAACATCCCCGCTCACCAGGAGCCCCTTGCCAGGAGTGTTCAAGATGCTCTCTCTGGACCGAT CCCACTATACAGATCCACGGGTTTTAGAAAAACAAGAATTACAGCAGCCAACCTATGTTGCCCTGAGTTACATAAATAGATTCATGACAG ATGCTGCCCGCCGAGAGCAGGAGTCCCTAAAGAAGAAGATTCAGCCGAAGCTCTCGCTGACTCTGTCCAGCTCAGTGTCTCGAGGGAATG TGTCCACTCCCCCACGCCACAGCAGTGGAAGCCTTACTCCCCCCGTGACCCCACCCATCACCCCCTCCTCTTCATTCCGCAGCAGCACTC CGACAGGCAGCGAGTATGACGAGGAGGAGGTGGACTATGAGGAGTCGGACAGCGATGAGTCCTGGACCACAGAGAGTGCCATCAGCTCCG AAGCCATCCTCAGCTCCATGTGCATGAATGGAGGGGAAGAGAAGCCTTTTGCCTGCCCAGTTCCTGGATGTAAAAAGAGATACAAGAATG TGAATGGCATAAAGTATCACGCTAAGAATGGTCACAGAACACAGATTCGTGTCCGCAAACCATTCAAGTGTCGCTGTGGGAAGAGTTACA AGACAGCTCAGGGCCTGCGGCACCACACAATCAATTTCCATCCCCCGGTGTCGGCTGAGATTATCAGGAAGATGCAGCAATAACATGCTG GTCATAACTGTGCCAAGAAATCCTCACCAGCAGTTGCTGATTTTGAAAACAGCCACCTTTTTTCAGGGGAAGCATTCAGCAACCCTTTAA AGAAAAAGAATTAAATGCATGCTTTAAATTTTTTCTGTAATTTTGGAATGATGTATCTTTGTAGAGTTAATGATTTTGTACATTTGCACA TGTAATCATCATACCCATTTTCATTACTTTGATATAAGGTGCTAAACAAAAAAAGCTCTAGGTTCTTCAGCACATTTCCCCCAAAACAAA ATAAAATTGAGGGCATGTTGCATATTGTTGAATTGTATTGCGGTGGTATCAACCTGGGGGGAGGAGGGGCTGGCACTGAGATTTTTTTTT CAAGATTGTAATGTGATTGAAGTTTTCAACACATCAACTCACATATGTTCAAAACCAAAATAATACCTTCATTATCAAACTGGTTACCAT GCCTTACATAATGGAGTTAGTATTTGTGAGTAGAAAGACTTTAGGTAATGGAAATATAAATAAGAAAGAATGTTTAACATAATATGCTAA AAATATTTTCATATTTAAATAACATACGTAAAGGTGTGCTTTCTGTGTTTTATATTATCTTGCAAATCCTTTTGCCCTTTAAAAAGCTGA AAATCTTGCCATCTGACTTACTAGTCATTTTAGTGTTATAAATGGCATTTTGTACAAAATAGTCTATTCAGTTCGTTCATTCATTTAACA CACATTGATTGAGTGCCTGCTGGGTACAAGGGATTCAATTTATGCCTATTGATATCTGCGGACCAAGATACCCATTTAGTGAAATACTTT TTTCCCTGAAATCTGTTAGAAAAGACTTTGAAATACTTCAGTGCAAAGTGTGTGTGTGTGAAGTTTAGTTATATCTTCATCTTCAGATGA AGTTTTAAAGCACTTTGTAGTTCTCTATTGCCAACAATTTAATGTTTATGTGTTGCCAATTCTTGCAACCACTGCCCTACCAAACCTGTG GGTTGCAAATCAGAACTAAAATTCTAAGCACGTTTCAAAGATGAACACTTTTGTTAAGACCCCTATTGCCTCTTCTTCATGCTCATTTTT TACTTTTTTTAAAAGGTACTTTTCTCATCACATTGTAGAGAGGTCTGCATTCTCATTGGAAATGTCTGTTTAGCTTTATAAAACAAACAC TTTGCTGAAATAGGAAAATGAGCCTTATTGACAATTAAGTGCTTCTTGCAGCAGGTGGTCAAAGAAAAGCATGACTAATACGACCTATTA GAGTAATCTACATCTGGACCATTCCTTAAGTTTTTCCTCACCGACAGTACCATCATGCCTTGAGTGTTCTTTTCTCCCAAGTGCTATTCC TTAAACACGAGAGTTTACCAGTTGCCTAATAATGCAATAAAAAATGCTTTGAGATAGCTAACTGCCCATAAAACAAACTCAAATTGCTTA TAAAGTTTCTTCCCATGTTCCCATTTGATGAAAAGTCTTACATCACATATAACTGGGAAGCAGGGGTCCCTCCTCAATTTTCAGACATTT TGAAAGGATGACAGTTCTGTTTGTTAGATGAGTAAACCTCTATATTCATAAGTTCTAAAATCCTTCATTATGAGGGATTCAAAGTATTTA TAAAAACACTGCCCTCTAAAAATTTCCTCAGATCTGAAGTATGGTCTTGGTCCTGAATATACAGTGTTATCCTATGTTTAAAAGGGTGAT CCAGACATGAGACGCAACTAGTTGGTGCATAAGAAGGCCCCACTTGGCTATTTCATATCTACCTACAATTGACCAAAAAAAATTTTTTAG GCCAGCAATTATTATTTAGCTTCGCTCTTTCTAGTGCAAGAAACTGCAGGCTGGATCAGTAGTTCAACAGCTAAACAGTCATAAAATAGT CATTGTGCATGTTAAATTTCTTTCAATGCTTTCAAAGATAAATTCCAATTTCTATTTACTTATTCATTGTGACAGTATTACTAAACAGGT AAGGATGGGAATATTTTGTTATACTGTGTATAGTGAATGTATTGTACTGTGTCTGTGAAAACTGTGCTTTAAATTATATTTTCATATGTT TTGTTGGGGACAGAGCACATTAAGTCTGAAAGCAACAGAGGTTTGTTTTAGAACTGAAGGCAATTTAATCAAAATTCCTGTCAAGAAAAG >75012_75012_2_RNF216-JAZF1_RNF216_chr7_5680785_ENST00000425013_JAZF1_chr7_28031600_ENST00000283928_length(amino acids)=747AA_BP= MHLKMEEGNNNEEVIHLNNFHCHRGQEWINLRDGPITISDSSDEERIPMLVTPAPQQHEEEDLDDDVILTEDDSEDDYGEFLDLGPPGIS EFTKPSGQTEREPKPGPSHNQAANDIVNPRSEQKVIILEEGSLLYTESDPLETQNQSSEDSETELLSNLGESAALADDQAIEEDCWLDHP YFQSLNQQPREITNQVVPQERQPEAELGRLLFQHEFPGPAFPRPEPQQGGISGPSSPQPAHPLGEFEDQQLASDDEEPGPAFPMQESQEP NLENIWGQEAAEVDQELVELLVKETEARFPDVANGFIEEIIHFKNYYDLNVLCNFLLENPDYPKREDRIIINPSSSLLASQDETKLPKID FFDYSKLTPLDQRCFIQAADLLMADFKVLSSQDIKWALHELKGHYAITRKALSDAIKKWQELSPETSGKRKKRKQMNQYSYIDFKFEQGD IKIEKRMFFLENKRRHCRSYDRRALLPAVQQEQEFYEQKIKEMAEHEDFLLALQMNEEQYQKDGQLIECRCCYGEFPFEELTQCADAHLF CKECLIRYAQEAVFGSGKLELSCMEGSCTCSFPTSELEKVLPQTILYKYYERKAEEEVAAAYADELVRCPSCSFPALLDSDVKRFSCPNP HCRKETCRKCQGLWKEHNGLTCEELAEKDDIKYRTSIEEKMTAARIRKCHKCGTGLIKSEGCNRMSCRCGAQMCYLCRVSINGYDHFCQH -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for RNF216-JAZF1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for RNF216-JAZF1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for RNF216-JAZF1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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