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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RNF217-ANKRD6 (FusionGDB2 ID:75022)

Fusion Gene Summary for RNF217-ANKRD6

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF217-ANKRD6
Fusion gene ID: 75022
HgeneTgene
Gene symbol

RNF217

ANKRD6

Gene ID

154214

22881

Gene namering finger protein 217ankyrin repeat domain 6
SynonymsC6orf172|IBRDC1|OSTL|dJ84N20.1-
Cytomap

6q22.31

6q15

Type of geneprotein-codingprotein-coding
Descriptionprobable E3 ubiquitin-protein ligase RNF217IBR domain containing 1opposite STLankyrin repeat domain-containing protein 6diego homologdiversinepididymis secretory sperm binding protein
Modification date2020031320200313
UniProtAcc.

Q9Y2G4

Ensembl transtripts involved in fusion geneENST00000521654, ENST00000560949, 
ENST00000275184, ENST00000359704, 
ENST00000368414, ENST00000454842, 
ENST00000339746, ENST00000447838, 
ENST00000485637, ENST00000520793, 
ENST00000520886, ENST00000522441, 
ENST00000369408, 
Fusion gene scores* DoF score8 X 5 X 9=3606 X 5 X 3=90
# samples 126
** MAII scorelog2(12/360*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF217 [Title/Abstract] AND ANKRD6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRNF217(125284572)-ANKRD6(90338831), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RNF217 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ANKRD6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-WK-A8XX-01ARNF217chr6

125284572

-ANKRD6chr6

90338831

+
ChimerDB4SARCTCGA-WK-A8XX-01ARNF217chr6

125284572

+ANKRD6chr6

90338831

+


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Fusion Gene ORF analysis for RNF217-ANKRD6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000521654ENST00000339746RNF217chr6

125284572

+ANKRD6chr6

90338831

+
5CDS-intronENST00000521654ENST00000447838RNF217chr6

125284572

+ANKRD6chr6

90338831

+
5CDS-intronENST00000521654ENST00000485637RNF217chr6

125284572

+ANKRD6chr6

90338831

+
5CDS-intronENST00000521654ENST00000520793RNF217chr6

125284572

+ANKRD6chr6

90338831

+
5CDS-intronENST00000521654ENST00000520886RNF217chr6

125284572

+ANKRD6chr6

90338831

+
5CDS-intronENST00000521654ENST00000522441RNF217chr6

125284572

+ANKRD6chr6

90338831

+
5CDS-intronENST00000560949ENST00000339746RNF217chr6

125284572

+ANKRD6chr6

90338831

+
5CDS-intronENST00000560949ENST00000447838RNF217chr6

125284572

+ANKRD6chr6

90338831

+
5CDS-intronENST00000560949ENST00000485637RNF217chr6

125284572

+ANKRD6chr6

90338831

+
5CDS-intronENST00000560949ENST00000520793RNF217chr6

125284572

+ANKRD6chr6

90338831

+
5CDS-intronENST00000560949ENST00000520886RNF217chr6

125284572

+ANKRD6chr6

90338831

+
5CDS-intronENST00000560949ENST00000522441RNF217chr6

125284572

+ANKRD6chr6

90338831

+
In-frameENST00000521654ENST00000369408RNF217chr6

125284572

+ANKRD6chr6

90338831

+
In-frameENST00000560949ENST00000369408RNF217chr6

125284572

+ANKRD6chr6

90338831

+
intron-3CDSENST00000275184ENST00000369408RNF217chr6

125284572

+ANKRD6chr6

90338831

+
intron-3CDSENST00000359704ENST00000369408RNF217chr6

125284572

+ANKRD6chr6

90338831

+
intron-3CDSENST00000368414ENST00000369408RNF217chr6

125284572

+ANKRD6chr6

90338831

+
intron-3CDSENST00000454842ENST00000369408RNF217chr6

125284572

+ANKRD6chr6

90338831

+
intron-intronENST00000275184ENST00000339746RNF217chr6

125284572

+ANKRD6chr6

90338831

+
intron-intronENST00000275184ENST00000447838RNF217chr6

125284572

+ANKRD6chr6

90338831

+
intron-intronENST00000275184ENST00000485637RNF217chr6

125284572

+ANKRD6chr6

90338831

+
intron-intronENST00000275184ENST00000520793RNF217chr6

125284572

+ANKRD6chr6

90338831

+
intron-intronENST00000275184ENST00000520886RNF217chr6

125284572

+ANKRD6chr6

90338831

+
intron-intronENST00000275184ENST00000522441RNF217chr6

125284572

+ANKRD6chr6

90338831

+
intron-intronENST00000359704ENST00000339746RNF217chr6

125284572

+ANKRD6chr6

90338831

+
intron-intronENST00000359704ENST00000447838RNF217chr6

125284572

+ANKRD6chr6

90338831

+
intron-intronENST00000359704ENST00000485637RNF217chr6

125284572

+ANKRD6chr6

90338831

+
intron-intronENST00000359704ENST00000520793RNF217chr6

125284572

+ANKRD6chr6

90338831

+
intron-intronENST00000359704ENST00000520886RNF217chr6

125284572

+ANKRD6chr6

90338831

+
intron-intronENST00000359704ENST00000522441RNF217chr6

125284572

+ANKRD6chr6

90338831

+
intron-intronENST00000368414ENST00000339746RNF217chr6

125284572

+ANKRD6chr6

90338831

+
intron-intronENST00000368414ENST00000447838RNF217chr6

125284572

+ANKRD6chr6

90338831

+
intron-intronENST00000368414ENST00000485637RNF217chr6

125284572

+ANKRD6chr6

90338831

+
intron-intronENST00000368414ENST00000520793RNF217chr6

125284572

+ANKRD6chr6

90338831

+
intron-intronENST00000368414ENST00000520886RNF217chr6

125284572

+ANKRD6chr6

90338831

+
intron-intronENST00000368414ENST00000522441RNF217chr6

125284572

+ANKRD6chr6

90338831

+
intron-intronENST00000454842ENST00000339746RNF217chr6

125284572

+ANKRD6chr6

90338831

+
intron-intronENST00000454842ENST00000447838RNF217chr6

125284572

+ANKRD6chr6

90338831

+
intron-intronENST00000454842ENST00000485637RNF217chr6

125284572

+ANKRD6chr6

90338831

+
intron-intronENST00000454842ENST00000520793RNF217chr6

125284572

+ANKRD6chr6

90338831

+
intron-intronENST00000454842ENST00000520886RNF217chr6

125284572

+ANKRD6chr6

90338831

+
intron-intronENST00000454842ENST00000522441RNF217chr6

125284572

+ANKRD6chr6

90338831

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000521654RNF217chr6125284572+ENST00000369408ANKRD6chr690338831+441188201580526
ENST00000560949RNF217chr6125284572+ENST00000369408ANKRD6chr690338831+4240711451409454

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000521654ENST00000369408RNF217chr6125284572+ANKRD6chr690338831+0.0021912250.99780875
ENST00000560949ENST00000369408RNF217chr6125284572+ANKRD6chr690338831+0.0032872390.9967128

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Fusion Genomic Features for RNF217-ANKRD6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RNF217chr6125284572+ANKRD6chr690338830+3.09E-050.9999691
RNF217chr6125284572+ANKRD6chr690338830+3.09E-050.9999691

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RNF217-ANKRD6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:125284572/chr6:90338831)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ANKRD6

Q9Y2G4

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANKRD6chr6:125284572chr6:90338831ENST000003397461316682_727495728.0Coiled coilOntology_term=ECO:0000255
TgeneANKRD6chr6:125284572chr6:90338831ENST000003694081215682_727460693.0Coiled coilOntology_term=ECO:0000255
TgeneANKRD6chr6:125284572chr6:90338831ENST000004478381316682_727495723.0Coiled coilOntology_term=ECO:0000255
TgeneANKRD6chr6:125284572chr6:90338831ENST000005207931013682_727436664.0Coiled coilOntology_term=ECO:0000255
TgeneANKRD6chr6:125284572chr6:90338831ENST000005224411316682_727495728.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF217chr6:125284572chr6:90338831ENST00000359704+19259_4780276.0RegionTRIAD supradomain
HgeneRNF217chr6:125284572chr6:90338831ENST00000359704+19503_5230276.0TransmembraneHelical
HgeneRNF217chr6:125284572chr6:90338831ENST00000359704+19263_3090276.0Zinc fingerRING-type 1
HgeneRNF217chr6:125284572chr6:90338831ENST00000359704+19328_3960276.0Zinc fingerIBR-type
HgeneRNF217chr6:125284572chr6:90338831ENST00000359704+19423_4520276.0Zinc fingerRING-type 2%3B atypical
TgeneANKRD6chr6:125284572chr6:90338831ENST000003397461316417_446495728.0Coiled coilOntology_term=ECO:0000255
TgeneANKRD6chr6:125284572chr6:90338831ENST000003694081215417_446460693.0Coiled coilOntology_term=ECO:0000255
TgeneANKRD6chr6:125284572chr6:90338831ENST000004478381316417_446495723.0Coiled coilOntology_term=ECO:0000255
TgeneANKRD6chr6:125284572chr6:90338831ENST000005207931013417_446436664.0Coiled coilOntology_term=ECO:0000255
TgeneANKRD6chr6:125284572chr6:90338831ENST000005224411316417_446495728.0Coiled coilOntology_term=ECO:0000255
TgeneANKRD6chr6:125284572chr6:90338831ENST000003397461316382_385495728.0Compositional biasNote=Poly-Pro
TgeneANKRD6chr6:125284572chr6:90338831ENST000003694081215382_385460693.0Compositional biasNote=Poly-Pro
TgeneANKRD6chr6:125284572chr6:90338831ENST000004478381316382_385495723.0Compositional biasNote=Poly-Pro
TgeneANKRD6chr6:125284572chr6:90338831ENST000005207931013382_385436664.0Compositional biasNote=Poly-Pro
TgeneANKRD6chr6:125284572chr6:90338831ENST000005224411316382_385495728.0Compositional biasNote=Poly-Pro
TgeneANKRD6chr6:125284572chr6:90338831ENST000003397461316107_136495728.0RepeatNote=ANK 4
TgeneANKRD6chr6:125284572chr6:90338831ENST000003397461316140_169495728.0RepeatNote=ANK 5
TgeneANKRD6chr6:125284572chr6:90338831ENST000003397461316173_202495728.0RepeatNote=ANK 6
TgeneANKRD6chr6:125284572chr6:90338831ENST000003397461316206_235495728.0RepeatNote=ANK 7
TgeneANKRD6chr6:125284572chr6:90338831ENST000003397461316239_268495728.0RepeatNote=ANK 8
TgeneANKRD6chr6:125284572chr6:90338831ENST00000339746131641_70495728.0RepeatNote=ANK 2
TgeneANKRD6chr6:125284572chr6:90338831ENST00000339746131674_103495728.0RepeatNote=ANK 3
TgeneANKRD6chr6:125284572chr6:90338831ENST0000033974613169_38495728.0RepeatNote=ANK 1
TgeneANKRD6chr6:125284572chr6:90338831ENST000003694081215107_136460693.0RepeatNote=ANK 4
TgeneANKRD6chr6:125284572chr6:90338831ENST000003694081215140_169460693.0RepeatNote=ANK 5
TgeneANKRD6chr6:125284572chr6:90338831ENST000003694081215173_202460693.0RepeatNote=ANK 6
TgeneANKRD6chr6:125284572chr6:90338831ENST000003694081215206_235460693.0RepeatNote=ANK 7
TgeneANKRD6chr6:125284572chr6:90338831ENST000003694081215239_268460693.0RepeatNote=ANK 8
TgeneANKRD6chr6:125284572chr6:90338831ENST00000369408121541_70460693.0RepeatNote=ANK 2
TgeneANKRD6chr6:125284572chr6:90338831ENST00000369408121574_103460693.0RepeatNote=ANK 3
TgeneANKRD6chr6:125284572chr6:90338831ENST0000036940812159_38460693.0RepeatNote=ANK 1
TgeneANKRD6chr6:125284572chr6:90338831ENST000004478381316107_136495723.0RepeatNote=ANK 4
TgeneANKRD6chr6:125284572chr6:90338831ENST000004478381316140_169495723.0RepeatNote=ANK 5
TgeneANKRD6chr6:125284572chr6:90338831ENST000004478381316173_202495723.0RepeatNote=ANK 6
TgeneANKRD6chr6:125284572chr6:90338831ENST000004478381316206_235495723.0RepeatNote=ANK 7
TgeneANKRD6chr6:125284572chr6:90338831ENST000004478381316239_268495723.0RepeatNote=ANK 8
TgeneANKRD6chr6:125284572chr6:90338831ENST00000447838131641_70495723.0RepeatNote=ANK 2
TgeneANKRD6chr6:125284572chr6:90338831ENST00000447838131674_103495723.0RepeatNote=ANK 3
TgeneANKRD6chr6:125284572chr6:90338831ENST0000044783813169_38495723.0RepeatNote=ANK 1
TgeneANKRD6chr6:125284572chr6:90338831ENST000005207931013107_136436664.0RepeatNote=ANK 4
TgeneANKRD6chr6:125284572chr6:90338831ENST000005207931013140_169436664.0RepeatNote=ANK 5
TgeneANKRD6chr6:125284572chr6:90338831ENST000005207931013173_202436664.0RepeatNote=ANK 6
TgeneANKRD6chr6:125284572chr6:90338831ENST000005207931013206_235436664.0RepeatNote=ANK 7
TgeneANKRD6chr6:125284572chr6:90338831ENST000005207931013239_268436664.0RepeatNote=ANK 8
TgeneANKRD6chr6:125284572chr6:90338831ENST00000520793101341_70436664.0RepeatNote=ANK 2
TgeneANKRD6chr6:125284572chr6:90338831ENST00000520793101374_103436664.0RepeatNote=ANK 3
TgeneANKRD6chr6:125284572chr6:90338831ENST0000052079310139_38436664.0RepeatNote=ANK 1
TgeneANKRD6chr6:125284572chr6:90338831ENST000005224411316107_136495728.0RepeatNote=ANK 4
TgeneANKRD6chr6:125284572chr6:90338831ENST000005224411316140_169495728.0RepeatNote=ANK 5
TgeneANKRD6chr6:125284572chr6:90338831ENST000005224411316173_202495728.0RepeatNote=ANK 6
TgeneANKRD6chr6:125284572chr6:90338831ENST000005224411316206_235495728.0RepeatNote=ANK 7
TgeneANKRD6chr6:125284572chr6:90338831ENST000005224411316239_268495728.0RepeatNote=ANK 8
TgeneANKRD6chr6:125284572chr6:90338831ENST00000522441131641_70495728.0RepeatNote=ANK 2
TgeneANKRD6chr6:125284572chr6:90338831ENST00000522441131674_103495728.0RepeatNote=ANK 3
TgeneANKRD6chr6:125284572chr6:90338831ENST0000052244113169_38495728.0RepeatNote=ANK 1


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Fusion Gene Sequence for RNF217-ANKRD6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>75022_75022_1_RNF217-ANKRD6_RNF217_chr6_125284572_ENST00000521654_ANKRD6_chr6_90338831_ENST00000369408_length(transcript)=4411nt_BP=882nt
ATGGGCGAGGAGCAGAGCACGGTGAGCGGCGGCGGCGGGCCCCAGGAGTCGCAGACCCTGGCCAGTGGCACTGCGGGCCACCCTGAGCCC
CCGAGGCCTCAGGGGGACAGCGCCCGGGCGCCCCCGCTGCGCGCCGCCTCCGCGGAGCCGAGCGGCGGTGGCTGCGGAAGCGACTGGGGC
TGCGCGGACACCAGCGCCCCAGAGCCCGCGAGGAGCCTGGGGCCCCCGGGCTGGAGTAAGAGCCGAGCACCGGCGCAGCCTGCGGGACTG
GCACTCACCGGGCCTCTCAATCCCCAGACCTTGCCACTGCAGTTGGAGCTGGAGGAGGAAGAGGAGGAAGCTGGGGATCGAAAAGAGGGA
GGGGATGAACAGCAGGAGGCGCCCCCCGGCGAAGAGCTGGAGCCCAGGACCCGCGTGGGGGCCGCCGACGGACTGGTCCTGGACGTGCTG
GGTCAGCGGCGCCCGTCCCTCGCCAAGAGACAAGTCTTCTGCTCCGTGTACTGCGTGGAGAGCGACCTGCCCGAGGCCCCCGCCTCGGAG
CAGCTCTCGCCGCCCGCGTCGCCACCTGGGGCTCCGCCAGTGTTGAACCCTCCCAGCACCCGCTCTTCCTTCCCCAGCCCCCGACTGTCC
CTCCCAACGGATTCCCTCTCCCCCGACGGCGGCAGCATCGAGCTGGAGTTCTACCTGGCGCCCGAGCCGTTCTCCATGCCCAGCCTGTTG
GGAGCTCCACCCTACTCTGGCCTGGGCGGTGTAGGGGATCCCTATGTGCCCCTCATGGTGCTGATGTGCCGGGTGTGCCTGGAAGACAAG
CCCATCAAGCCCCTGCCTTGCTGCAAGAAGGCCGTGTGCGAGGAGTGCCTCAAAGTCTACCTGAGCGCCCAGATATCCTTGGTGGATGAA
TTAAAAACCTGGTGCATGTTAAAGATTCAGAATCTGGAGCAGAAGCTTTCTGGAGATTCTAGGGCCTGCAGAGCTAAATCCACACCATCT
ACTTGTGAGTCCTCTACAGGTGTGGACCAATTAGTGGTGACTGCAGGTCCAGCAGCAGCTTCCGACAGCTCCCCTCCAGTGGTTAGGCCC
AAAGAGAAGGCCCTCAACTCCACTGCTACCCAGAGACTCCAGCAGGAGCTGTCGTCTTCTGACTGTACAGGCTCCCGACTGAGAAACGTC
AAGGTCCAGACAGCCTTGCTACCCATGAATGAGGCAGCCAGATCTGATCAGCAGGCTGGGCCCTGCGTCAACAGAGGCACTCAAACTAAG
AAGTCTGGGAAGAGTGGGCCAACAAGGCATCGTGCCCAGCAACCCGCAGCCAGCAGCACCTGTGGGCAGCCGCCACCAGCCACAGGCAGC
GAGCAGACTGGCCCTCACATTCGGGACACCTCCCAAGCTCTGGAGCTTACCCAGTATTTTTTTGAGGCTGTTTCTACCCAGATGGAAAAG
TGGTATGAAAGGAAGATTGAAGAAGCACGAAGCCAAGCCAATCAGAAAGCCCAGCAAGATAAGGCTACATTGAAGGAACACATTAAAAGT
TTAGAAGAGGAACTTGCCAAACTAAGGACTAGGGTGCAGAAGGAAAATTAGCACCAATAAAGAGGAAATATGAAAGGATTCTTGAAGATT
TCCAGTTTTGCAACTGCATAATAGCTATGCCCAAGGAGTCAACTATTGTATATATTGCAGATTTGCCTTTTTAAAAAAATCACTAATTCT
ACAATGTGCCAGATACATGTTTCCTATGCCCAGGAAGTTATGAAGACTTCAACAATTAAACTGAAACCAGGGGAAGCTTGCTTAGTTTTG
GGTTTCATTATAAACTCTTAGCCTCAGTCCAGGTTAATCTGAAGTTTGAAAGCTCAGATTAAGCAAGCCATGCCAAGAAACTGGACGATG
TGTAAGCCTAGACTCTAAAATTCAAGATGTGTGAAATAATATAAGTCAAAAGCAAGAAAAACGTAATCCCGTCTGAACTCAAGTAGTCAT
TCATATAAATTTGAACACACCTGCTGTGCCTAGACAAGTGTCTTTCTGTAAGAGCTGTAACTCTGAGATGTGCTAAATAAACCCTCTTTC
TCAAATTCGTAATTCTCCAACTGTTGACATTTTAATCACATGAAAAGTTATCAGATTTTTGAGGAGAAATATTTTCATGATGTCACAAGA
TCCAATATATCTTATGATAAAATTTATTGAAAAGTCAGTTTATTTAAATAATGAATAATTGGCTAACAGCTCTGGAAACAATGAGATCAA
ATGAGAAAGATTCAAATTGTTTGTTATTTTCTGTATTTTCAGTCAAAAAATCAGTTATATAGTGATTTTAAAGCAGATTAATGGAAAAAA
ATTCATGTAACAATTACCTGAAAATTTATAACCTATTCCTAATCAAACCCAATTATATCAGAATACCTTTCTGAATTTGAGATTTTTGCT
CTACATTTTATAATGAATAAGGCTATTTTTTGAAAGTATTTCATTTTGAATTCTGTCATTAACCTCAAAAGCTTTCTACTGCTTTGCGGT
GAAGGCAAAATATTCGATAACTCAACTTAGGCCCCACTGTTCCCCAACTTCATGGAGGCCAGAAGACTTTACTTTGTTCCATAATGAAAT
ATAAACACAGAACAAAGTTGTAAAAGTAGCATGGATATGTTGAAACTTTGGACAAGCTTCTTGTCCTTTGGAATATGGGATTTATATTCA
TCTCCTCAATATCCCATGTATGCACAGAAACTTCAGTTCTATTTCTATAGACACAGGAACCTAGTGACTATTGAACGTAATTGTAATAAA
ATGCTGCTCATTGAGCCAAAGAGAAGAAATGATTTATTAACATGGGGACACCAAGAAAAACAAAGTATGCTTTTATTCCCTTTGTCAAGC
TCAGTTTTAGGGTTTTTTCTTTTTTTTATAGTGACAATCCATAGATATAGACATTCCTAAAAGAAAAATAATTCAGTAGATATATGTCAC
TGTTACCTGAATATGGAATGAATTTGATGTTTTTTATTTTGTTGAGACAGGGTCTTGCTCTGTCACCCAGACTGGAGTGCAGTGGCATGA
TCACACCTCACTGCAGCCTTGGCCTCTCAGGCTCGTGATCCTCCTGCCTCAACCTCGCAAGTAGCTTGGGACTACAGGCGTGTGCCACCA
GTCCTGGCTAATTTTTTGTAGATATAAGGTCTCATGATATTGCCCAGGCTGAATTTGATGTTATTTCAAGTTGATTTTCATGTGTTTGGG
AGCTTGTCTTGTTCTCAACTACTACGCAGGTAGACAGTCTTCCCCCAGAGACTCATTAGATTGCAATATAGAGGCACTTTCTCATTTCCC
TATTGTTCCTAATACAGAATTGTAGAGCTGGAGAGTACCTTCAGTTTTCTAAATCTATTCTCAAACAGGATATCACTAACCTCTTTAGAA
TCATTCCTCAGTATACATCAATTTATTGAGAACTGCCTAATACTCAAGAAATTAAATCCTGAGTTCAGTAGGCTGTGTTCCAAGCAGGAA
TTATTTTCACTTACCAAAATATCTCCTATTACCTCAAGGTATCCTTGTTGAGGAATGCTGAAAACTAAATTTTAAGTATCAAGTCTAGAC
CATAGAGTGCTTTGGTGGGAGTATTTTGATTACCTCCTACCCATCAGAAGCAGGCAGCTAATATTGTGAACTGAGTATTTTTGTCAAAAG
TCACAGGGAAGAGACTACAGAAGAATGAGAAGGGTCAAAAGGACCTAGTGTGGCTTACTACATGGATCTTGTCTCTTGGAGGTCTGTCGT
AGAAGAAGAAACAAATAGAGGTGATGAAGACACAGAACAGGCTCAGTCAGCATCCTCACCCAGAGATGGCAACATCTATTAAGACCAATG
CAATACCTTTTCATCTTCAGCAAATGTTGTTTCATCTGTTTTTGATCCTTGGCATTGTCAAAAACTTAACTGCAGGTCCAGTGTATATTT
TTCCTTATTTTTCCCTTTTAGCTATCTGCTAAAGTGAGTAAATGCCACAACTGTACTTTTCCAAAGAAAAAGAACTATTGACAACTTATA
GCCTGTCATGCAGGTCATGTTTCAAATCAAGGCTGAAATTTTCAACAGCTGTGGGAAAAACTAAAACACAGAAATACTGTACAGTATTAG
TGTTTTTTTAAAGAAATTGTTAGTGCATTATTGAGTATACTAAATATCTGTGATTAAATAAATTAGTTCTAACTTTTGATTTTGGGAGCC
CAAAATAAAGGGAGTGTTGTTTTCATGGTTATGCCTTGTTTGTGGAGTCAAGTGTTGATATACTTGAGGCATGTTATGTGTCTTCTAATT
AATATTTTTATCACCTTGAATTTGTGTCTCTTCCAAGCATTAAAGATACTATGGATCTTAAATTCCTTATTAAAAAAATGCAAGTGTGAA

>75022_75022_1_RNF217-ANKRD6_RNF217_chr6_125284572_ENST00000521654_ANKRD6_chr6_90338831_ENST00000369408_length(amino acids)=526AA_BP=294
MGEEQSTVSGGGGPQESQTLASGTAGHPEPPRPQGDSARAPPLRAASAEPSGGGCGSDWGCADTSAPEPARSLGPPGWSKSRAPAQPAGL
ALTGPLNPQTLPLQLELEEEEEEAGDRKEGGDEQQEAPPGEELEPRTRVGAADGLVLDVLGQRRPSLAKRQVFCSVYCVESDLPEAPASE
QLSPPASPPGAPPVLNPPSTRSSFPSPRLSLPTDSLSPDGGSIELEFYLAPEPFSMPSLLGAPPYSGLGGVGDPYVPLMVLMCRVCLEDK
PIKPLPCCKKAVCEECLKVYLSAQISLVDELKTWCMLKIQNLEQKLSGDSRACRAKSTPSTCESSTGVDQLVVTAGPAAASDSSPPVVRP
KEKALNSTATQRLQQELSSSDCTGSRLRNVKVQTALLPMNEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRAQQPAASSTCGQPPPATGS

--------------------------------------------------------------
>75022_75022_2_RNF217-ANKRD6_RNF217_chr6_125284572_ENST00000560949_ANKRD6_chr6_90338831_ENST00000369408_length(transcript)=4240nt_BP=711nt
GACTGGGGCTGCGCGGACACCAGCGCCCCAGAGCCCGCGAGGAGCCTGGGGCCCCCGGGCTGGAGTAAGAGCCGAGCACCGGCGCAGCCT
GCGGGACTGGCACTCACCGGGCCTCTCAATCCCCAGACCTTGCCACTGCAGTTGGAGCTGGAGGAGGAAGAGGAGGAAGCTGGGGATCGA
AAAGAGGGAGGGGATGAACAGCAGGAGGCGCCCCCCGGCGAAGAGCTGGAGCCCAGGACCCGCGTGGGGGCCGCCGACGGACTGGTCCTG
GACGTGCTGGGTCAGCGGCGCCCGTCCCTCGCCAAGAGACAAGTCTTCTGCTCCGTGTACTGCGTGGAGAGCGACCTGCCCGAGGCCCCC
GCCTCGGAGCAGCTCTCGCCGCCCGCGTCGCCACCTGGGGCTCCGCCAGTGTTGAACCCTCCCAGCACCCGCTCTTCCTTCCCCAGCCCC
CGACTGTCCCTCCCAACGGATTCCCTCTCCCCCGACGGCGGCAGCATCGAGCTGGAGTTCTACCTGGCGCCCGAGCCGTTCTCCATGCCC
AGCCTGTTGGGAGCTCCACCCTACTCTGGCCTGGGCGGTGTAGGGGATCCCTATGTGCCCCTCATGGTGCTGATGTGCCGGGTGTGCCTG
GAAGACAAGCCCATCAAGCCCCTGCCTTGCTGCAAGAAGGCCGTGTGCGAGGAGTGCCTCAAAGTCTACCTGAGCGCCCAGATATCCTTG
GTGGATGAATTAAAAACCTGGTGCATGTTAAAGATTCAGAATCTGGAGCAGAAGCTTTCTGGAGATTCTAGGGCCTGCAGAGCTAAATCC
ACACCATCTACTTGTGAGTCCTCTACAGGTGTGGACCAATTAGTGGTGACTGCAGGTCCAGCAGCAGCTTCCGACAGCTCCCCTCCAGTG
GTTAGGCCCAAAGAGAAGGCCCTCAACTCCACTGCTACCCAGAGACTCCAGCAGGAGCTGTCGTCTTCTGACTGTACAGGCTCCCGACTG
AGAAACGTCAAGGTCCAGACAGCCTTGCTACCCATGAATGAGGCAGCCAGATCTGATCAGCAGGCTGGGCCCTGCGTCAACAGAGGCACT
CAAACTAAGAAGTCTGGGAAGAGTGGGCCAACAAGGCATCGTGCCCAGCAACCCGCAGCCAGCAGCACCTGTGGGCAGCCGCCACCAGCC
ACAGGCAGCGAGCAGACTGGCCCTCACATTCGGGACACCTCCCAAGCTCTGGAGCTTACCCAGTATTTTTTTGAGGCTGTTTCTACCCAG
ATGGAAAAGTGGTATGAAAGGAAGATTGAAGAAGCACGAAGCCAAGCCAATCAGAAAGCCCAGCAAGATAAGGCTACATTGAAGGAACAC
ATTAAAAGTTTAGAAGAGGAACTTGCCAAACTAAGGACTAGGGTGCAGAAGGAAAATTAGCACCAATAAAGAGGAAATATGAAAGGATTC
TTGAAGATTTCCAGTTTTGCAACTGCATAATAGCTATGCCCAAGGAGTCAACTATTGTATATATTGCAGATTTGCCTTTTTAAAAAAATC
ACTAATTCTACAATGTGCCAGATACATGTTTCCTATGCCCAGGAAGTTATGAAGACTTCAACAATTAAACTGAAACCAGGGGAAGCTTGC
TTAGTTTTGGGTTTCATTATAAACTCTTAGCCTCAGTCCAGGTTAATCTGAAGTTTGAAAGCTCAGATTAAGCAAGCCATGCCAAGAAAC
TGGACGATGTGTAAGCCTAGACTCTAAAATTCAAGATGTGTGAAATAATATAAGTCAAAAGCAAGAAAAACGTAATCCCGTCTGAACTCA
AGTAGTCATTCATATAAATTTGAACACACCTGCTGTGCCTAGACAAGTGTCTTTCTGTAAGAGCTGTAACTCTGAGATGTGCTAAATAAA
CCCTCTTTCTCAAATTCGTAATTCTCCAACTGTTGACATTTTAATCACATGAAAAGTTATCAGATTTTTGAGGAGAAATATTTTCATGAT
GTCACAAGATCCAATATATCTTATGATAAAATTTATTGAAAAGTCAGTTTATTTAAATAATGAATAATTGGCTAACAGCTCTGGAAACAA
TGAGATCAAATGAGAAAGATTCAAATTGTTTGTTATTTTCTGTATTTTCAGTCAAAAAATCAGTTATATAGTGATTTTAAAGCAGATTAA
TGGAAAAAAATTCATGTAACAATTACCTGAAAATTTATAACCTATTCCTAATCAAACCCAATTATATCAGAATACCTTTCTGAATTTGAG
ATTTTTGCTCTACATTTTATAATGAATAAGGCTATTTTTTGAAAGTATTTCATTTTGAATTCTGTCATTAACCTCAAAAGCTTTCTACTG
CTTTGCGGTGAAGGCAAAATATTCGATAACTCAACTTAGGCCCCACTGTTCCCCAACTTCATGGAGGCCAGAAGACTTTACTTTGTTCCA
TAATGAAATATAAACACAGAACAAAGTTGTAAAAGTAGCATGGATATGTTGAAACTTTGGACAAGCTTCTTGTCCTTTGGAATATGGGAT
TTATATTCATCTCCTCAATATCCCATGTATGCACAGAAACTTCAGTTCTATTTCTATAGACACAGGAACCTAGTGACTATTGAACGTAAT
TGTAATAAAATGCTGCTCATTGAGCCAAAGAGAAGAAATGATTTATTAACATGGGGACACCAAGAAAAACAAAGTATGCTTTTATTCCCT
TTGTCAAGCTCAGTTTTAGGGTTTTTTCTTTTTTTTATAGTGACAATCCATAGATATAGACATTCCTAAAAGAAAAATAATTCAGTAGAT
ATATGTCACTGTTACCTGAATATGGAATGAATTTGATGTTTTTTATTTTGTTGAGACAGGGTCTTGCTCTGTCACCCAGACTGGAGTGCA
GTGGCATGATCACACCTCACTGCAGCCTTGGCCTCTCAGGCTCGTGATCCTCCTGCCTCAACCTCGCAAGTAGCTTGGGACTACAGGCGT
GTGCCACCAGTCCTGGCTAATTTTTTGTAGATATAAGGTCTCATGATATTGCCCAGGCTGAATTTGATGTTATTTCAAGTTGATTTTCAT
GTGTTTGGGAGCTTGTCTTGTTCTCAACTACTACGCAGGTAGACAGTCTTCCCCCAGAGACTCATTAGATTGCAATATAGAGGCACTTTC
TCATTTCCCTATTGTTCCTAATACAGAATTGTAGAGCTGGAGAGTACCTTCAGTTTTCTAAATCTATTCTCAAACAGGATATCACTAACC
TCTTTAGAATCATTCCTCAGTATACATCAATTTATTGAGAACTGCCTAATACTCAAGAAATTAAATCCTGAGTTCAGTAGGCTGTGTTCC
AAGCAGGAATTATTTTCACTTACCAAAATATCTCCTATTACCTCAAGGTATCCTTGTTGAGGAATGCTGAAAACTAAATTTTAAGTATCA
AGTCTAGACCATAGAGTGCTTTGGTGGGAGTATTTTGATTACCTCCTACCCATCAGAAGCAGGCAGCTAATATTGTGAACTGAGTATTTT
TGTCAAAAGTCACAGGGAAGAGACTACAGAAGAATGAGAAGGGTCAAAAGGACCTAGTGTGGCTTACTACATGGATCTTGTCTCTTGGAG
GTCTGTCGTAGAAGAAGAAACAAATAGAGGTGATGAAGACACAGAACAGGCTCAGTCAGCATCCTCACCCAGAGATGGCAACATCTATTA
AGACCAATGCAATACCTTTTCATCTTCAGCAAATGTTGTTTCATCTGTTTTTGATCCTTGGCATTGTCAAAAACTTAACTGCAGGTCCAG
TGTATATTTTTCCTTATTTTTCCCTTTTAGCTATCTGCTAAAGTGAGTAAATGCCACAACTGTACTTTTCCAAAGAAAAAGAACTATTGA
CAACTTATAGCCTGTCATGCAGGTCATGTTTCAAATCAAGGCTGAAATTTTCAACAGCTGTGGGAAAAACTAAAACACAGAAATACTGTA
CAGTATTAGTGTTTTTTTAAAGAAATTGTTAGTGCATTATTGAGTATACTAAATATCTGTGATTAAATAAATTAGTTCTAACTTTTGATT
TTGGGAGCCCAAAATAAAGGGAGTGTTGTTTTCATGGTTATGCCTTGTTTGTGGAGTCAAGTGTTGATATACTTGAGGCATGTTATGTGT
CTTCTAATTAATATTTTTATCACCTTGAATTTGTGTCTCTTCCAAGCATTAAAGATACTATGGATCTTAAATTCCTTATTAAAAAAATGC

>75022_75022_2_RNF217-ANKRD6_RNF217_chr6_125284572_ENST00000560949_ANKRD6_chr6_90338831_ENST00000369408_length(amino acids)=454AA_BP=222
MGPPGWSKSRAPAQPAGLALTGPLNPQTLPLQLELEEEEEEAGDRKEGGDEQQEAPPGEELEPRTRVGAADGLVLDVLGQRRPSLAKRQV
FCSVYCVESDLPEAPASEQLSPPASPPGAPPVLNPPSTRSSFPSPRLSLPTDSLSPDGGSIELEFYLAPEPFSMPSLLGAPPYSGLGGVG
DPYVPLMVLMCRVCLEDKPIKPLPCCKKAVCEECLKVYLSAQISLVDELKTWCMLKIQNLEQKLSGDSRACRAKSTPSTCESSTGVDQLV
VTAGPAAASDSSPPVVRPKEKALNSTATQRLQQELSSSDCTGSRLRNVKVQTALLPMNEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRA
QQPAASSTCGQPPPATGSEQTGPHIRDTSQALELTQYFFEAVSTQMEKWYERKIEEARSQANQKAQQDKATLKEHIKSLEEELAKLRTRV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RNF217-ANKRD6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RNF217-ANKRD6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RNF217-ANKRD6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource