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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RNF24-CDS2 (FusionGDB2 ID:75045)

Fusion Gene Summary for RNF24-CDS2

check button Fusion gene summary
Fusion gene informationFusion gene name: RNF24-CDS2
Fusion gene ID: 75045
HgeneTgene
Gene symbol

RNF24

CDS2

Gene ID

11237

8760

Gene namering finger protein 24CDP-diacylglycerol synthase 2
SynonymsG1L-
Cytomap

20p13

20p12.3

Type of geneprotein-codingprotein-coding
DescriptionRING finger protein 24phosphatidate cytidylyltransferase 2CDP-DAG synthase 2CDP-DG synthase 2CDP-DG synthetase 2CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2CDP-diglyceride diphosphorylase 2CDP-diglyceride pyrophosphorylase 2CDP-diglyceride synthase
Modification date2020031320200327
UniProtAcc.

O95674

Ensembl transtripts involved in fusion geneENST00000336095, ENST00000358395, 
ENST00000432261, ENST00000545616, 
ENST00000379062, ENST00000379070, 
ENST00000535100, ENST00000460006, 
Fusion gene scores* DoF score9 X 8 X 5=36010 X 11 X 7=770
# samples 1013
** MAII scorelog2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/770*10)=-2.56634682255381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNF24 [Title/Abstract] AND CDS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRNF24(3925824)-CDS2(5154169), # samples:2
Anticipated loss of major functional domain due to fusion event.RNF24-CDS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
RNF24-CDS2 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RNF24 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CDS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-78-7145-01ARNF24chr20

3925824

-CDS2chr20

5154169

+


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Fusion Gene ORF analysis for RNF24-CDS2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000336095ENST00000379062RNF24chr20

3925824

-CDS2chr20

5154169

+
5CDS-intronENST00000336095ENST00000379070RNF24chr20

3925824

-CDS2chr20

5154169

+
5CDS-intronENST00000336095ENST00000535100RNF24chr20

3925824

-CDS2chr20

5154169

+
5CDS-intronENST00000358395ENST00000379062RNF24chr20

3925824

-CDS2chr20

5154169

+
5CDS-intronENST00000358395ENST00000379070RNF24chr20

3925824

-CDS2chr20

5154169

+
5CDS-intronENST00000358395ENST00000535100RNF24chr20

3925824

-CDS2chr20

5154169

+
5CDS-intronENST00000432261ENST00000379062RNF24chr20

3925824

-CDS2chr20

5154169

+
5CDS-intronENST00000432261ENST00000379070RNF24chr20

3925824

-CDS2chr20

5154169

+
5CDS-intronENST00000432261ENST00000535100RNF24chr20

3925824

-CDS2chr20

5154169

+
5CDS-intronENST00000545616ENST00000379062RNF24chr20

3925824

-CDS2chr20

5154169

+
5CDS-intronENST00000545616ENST00000379070RNF24chr20

3925824

-CDS2chr20

5154169

+
5CDS-intronENST00000545616ENST00000535100RNF24chr20

3925824

-CDS2chr20

5154169

+
Frame-shiftENST00000358395ENST00000460006RNF24chr20

3925824

-CDS2chr20

5154169

+
Frame-shiftENST00000545616ENST00000460006RNF24chr20

3925824

-CDS2chr20

5154169

+
In-frameENST00000336095ENST00000460006RNF24chr20

3925824

-CDS2chr20

5154169

+
In-frameENST00000432261ENST00000460006RNF24chr20

3925824

-CDS2chr20

5154169

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000336095RNF24chr203925824-ENST00000460006CDS2chr205154169+94144801411760539
ENST00000432261RNF24chr203925824-ENST00000460006CDS2chr205154169+922529101571523

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000336095ENST00000460006RNF24chr203925824-CDS2chr205154169+0.0009413790.99905866
ENST00000432261ENST00000460006RNF24chr203925824-CDS2chr205154169+0.0012307080.9987692

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Fusion Genomic Features for RNF24-CDS2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RNF24chr203925823-CDS2chr205154168+1.77E-060.9999982
RNF24chr203925823-CDS2chr205154168+1.77E-060.9999982

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RNF24-CDS2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:3925824/chr20:5154169)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CDS2

O95674

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:25375833). Exhibits specificity for the nature of the acyl chains at the sn-1 and sn-2 positions in the substrate, PA and the preferred acyl chain composition is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid (PubMed:25375833). Plays an important role in regulating the growth and maturation of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed:26946540, PubMed:31548309). {ECO:0000269|PubMed:25375833, ECO:0000269|PubMed:26946540, ECO:0000269|PubMed:31548309}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF24chr20:3925824chr20:5154169ENST00000336095-4624_4476149.0TransmembraneHelical
HgeneRNF24chr20:3925824chr20:5154169ENST00000358395-4624_4476149.0TransmembraneHelical
HgeneRNF24chr20:3925824chr20:5154169ENST00000432261-4624_4497170.0TransmembraneHelical
HgeneRNF24chr20:3925824chr20:5154169ENST00000545616-5724_4497170.0TransmembraneHelical
TgeneCDS2chr20:3925824chr20:5154169ENST00000460006013132_15219446.0TransmembraneHelical
TgeneCDS2chr20:3925824chr20:5154169ENST00000460006013166_18619446.0TransmembraneHelical
TgeneCDS2chr20:3925824chr20:5154169ENST00000460006013213_23319446.0TransmembraneHelical
TgeneCDS2chr20:3925824chr20:5154169ENST00000460006013262_28219446.0TransmembraneHelical
TgeneCDS2chr20:3925824chr20:5154169ENST00000460006013340_36019446.0TransmembraneHelical
TgeneCDS2chr20:3925824chr20:5154169ENST0000046000601379_9919446.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF24chr20:3925824chr20:5154169ENST00000336095-4678_11976149.0Zinc fingerRING-type
HgeneRNF24chr20:3925824chr20:5154169ENST00000358395-4678_11976149.0Zinc fingerRING-type
HgeneRNF24chr20:3925824chr20:5154169ENST00000432261-4678_11997170.0Zinc fingerRING-type
HgeneRNF24chr20:3925824chr20:5154169ENST00000545616-5778_11997170.0Zinc fingerRING-type


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Fusion Gene Sequence for RNF24-CDS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>75045_75045_1_RNF24-CDS2_RNF24_chr20_3925824_ENST00000336095_CDS2_chr20_5154169_ENST00000460006_length(transcript)=9414nt_BP=480nt
CTGGGGTTTGGGGGACCGAGCCGCTCCGGGTTCGGGATGCTGAGGAGACCGCGGGCCCGCGCCAGCCTCCCACACACACACACTCTCCCG
GCGCCTCGGCCGGCCGGGCGCGGTGTGCAGGGGTGAGGCGGTGTCTCCAGGCTGAGGAGGGACGCGGAGGAGGGTCCGGCGCGGCCCCGG
GACTGGAGGGTGAGTCCCTCACAAAGGGCGGAGCGGGGCTGTCACCTGGAGATCACGGAGGGAAGTTCATCCATGAGCTCGGATTTCCCA
CATTACAACTTCAGGATGCCTAATATTGGATTCCAGAATCTGCCTCTCAACATATATATTGTGGTTTTTGGTACTGCTATATTTGTCTTC
ATCCTTAGTTTACTCTTCTGTTGCTACTTGATTAGGCTAAGACATCAAGCACACAAAGAATTTTATGCCTACAAACAGGTTATATTAAAA
GAGAAAGTAAAAGAATTGAATTTACATGAGGAGTCAGAGTCAGAAGCAAAGGTAGATGGAGAGACTGCATCGGACAGTGAGAGCCGGGCA
GAATCCGCACCCCTGCCAGTCTCTGCAGATGATACCCCGGAGGTCCTCAATAGGGCCCTTTCCAACTTGTCTTCAAGATGGAAGAACTGG
TGGGTGAGAGGCATCCTGACTTTGGCCATGATTGCATTTTTCTTCATCATCATTTACCTGGGACCAATGGTTTTGATGATAATCGTGATG
TGCGTTCAGATTAAGTGTTTCCATGAGATAATCACTATTGGCTACAACGTCTACCACTCATATGATCTGCCCTGGTTCAGGACGCTCAGC
TGGTACTTTCTCCTGTGTGTAAACTATTTCTTCTATGGTGAGACAGTGACGGATTACTTCTTCACCCTGGTCCAGAGAGAAGAGCCTTTG
CGGATTCTCAGTAAATACCACCGGTTCATTTCCTTTACTCTCTATCTAATAGGATTCTGCATGTTTGTACTGAGTCTGGTCAAGAAGCAT
TATCGACTGCAGTTCTACATGTTTGGCTGGACCCATGTGACATTGCTGATTGTTGTAACACAGTCACATCTTGTTATCCACAACCTATTT
GAAGGAATGATCTGGTTCATTGTCCCCATATCTTGTGTGATCTGTAATGACATCATGGCCTATATGTTTGGCTTTTTCTTTGGTCGGACC
CCACTCATCAAGCTGTCCCCGAAGAAGACCTGGGAAGGCTTCATTGGGGGCTTCTTTGCTACTGTGGTGTTTGGCCTTCTGCTGTCCTAT
GTGATGTCCGGGTACAGATGCTTTGTCTGCCCTGTGGAGTACAACAATGACACCAACAGCTTCACTGTGGACTGTGAGCCCTCGGACCTG
TTTCGCCTGCAGGAGTACAACATTCCTGGGGTGATCCAGTCAGTCATTGGCTGGAAAACGGTCCGGATGTACCCCTTCCAGATTCACAGC
ATCGCTCTCTCCACCTTTGCCTCGCTCATTGGCCCCTTTGGAGGATTCTTCGCAAGTGGATTCAAACGAGCCTTTAAAATCAAAGACTTT
GCCAATACCATTCCTGGCCATGGAGGCATCATGGATCGCTTTGACTGCCAGTATCTGATGGCCACCTTTGTCAATGTATACATCGCCAGT
TTTATCAGAGGCCCTAACCCAAGCAAACTGATTCAGCAGTTCCTGACTTTACGGCCAGATCAGCAGCTCCACATCTTCAACACGCTGCGG
TCTCATCTGATCGACAAAGGGATGCTGACATCCACCACAGAGGACGAGTAGGGGCCACCCAGGGCCAGGAGAACAGGAACAGAACTGAGC
AGGGGCAGGTCTCCAAGGCAAGCCCAGCTGGTGTGACTTAGACAATGACGAGGCTTCAACTCACTGTCTTTTTTTTTTTTTTTTGGAGGG
TATTTTTTATTTGTGGGTTCAAAAAATCTGTATATACAGTCTATGTGTTTAGAATTTGTGTTGTAAGTAAACTACAGCTTTGAGTTGGAA
AGAAGTCACGGGTTGTAAAACCATTTGGATTTTTTTAAAACAAAAGTATTAATAATCTGGAAGACAGTGTTGCCCAGGTCAGGAGTGTTT
TCTTGGTGGTTCCAGCCCCCATCAATTGAACTGTTTCTGGGCTCAGTCAGACACAGACATTCATCTGTGTCTGACCAAATCAGGGGACTT
CCCCACCTGTGGTGGGAGGCACAGCTTAGATGTTTTGTACACCTGGTCTTTTCTAGAAATCCCTGCTTGGAGCTGCAGAAGGGTTGCCTT
CTGTAGGTCGGAGGAATGGAGGCTTACTAACCAGGTAAGCCTTCTATGCATCCACACCAAAATCCTGCAGAATGTAAGTAAGCTCTGCTT
TATAAGATGGGTTCACCTTCATCGCAGACTGAAAGTTTCAGTTTTTATTTTTTTCAGAAAGCACGAAAAATTATTTATAATAGTCTGGAG
AAAAAACACACTGTAATATTTCAAGTGTATGCAGTAGAATGTACTGTAACTGAGCCCTTTCCCACATGTCTAGGCTCCAATGTCTCCTGT
AGGTCCACCTAACTGTGTGTTTTCAGGGACAATGCCATCCATGTTTGTGCTGTAGACTTGCTGCTGCTGAATCCTTTCTGGGGACTTTCT
CATCGGGCAGGGAGCAGAGGGCTTCTCGTTCATGCACCCTTTGCCTGAACACCCATGTAGCTGCTGTGTTGTGTATATATTACTCTTAAG
AGGAGTGTGTGTGTCTGTGTTTGTTTTAAAAGTCACTTATTTCTTACAGTGATTTCAATTGCACCATGACTTCTTCACTAAAACCACAAA
GTCCTGCTTAAAACTATGGAAAACCTAACCTGATTAGAGCCTTGACTATTTTGAAGATTAAATGCACACTTTTTATATAATGTGACCAGT
TTAAATGTAGTTTGTATTGTACTGGGGGACCTTTCGTTGTTGTTGTTTGCTTAAACTGTGATTTTTTTTCCCCTCCCTAATTTCAGGGGT
GAGATTGACTTTGGGAAGACAGATTAGTTCTTTGTCAGGCCAACAAGTGATGGAGTGCGGGAGAGAGAACTTGGCACCCAAATATATCAA
ACTATTCCGTGCCGTGGATGTTTTCATTGCCAACGAGGGTGTAATGATTTGCTTCTGCACCTTGGTCTAGTGCTGGTTTGTGGTGTTTTT
GTTTGTAAATTAGCCTCACTGCCTCCCTGAAAGTGCACAGTCAGCCCAGGTCTCTAGAGTGTCCAGCAGAGGATGGAGCCCTCGGGATGT
TTCAGCTCACACATCCTTGAGTGACTTCCCATATGTGTGTGGGGCTGAAGCGGCTTCTTTCCGCTGAACTTTTATTTCCATTTCAGCCTC
GTGGCTTCTCTTATTCAGGTCCAAGGCCCCTTAAAAACAAAACATATTATCGCAAGGGCTTTCATTTCAGTATTGGCTGTGTCACTGGCA
GGATGCATCACTCTCCAGGGCCTCTTTTTCGGAGCTACTCCCAATTCCACTCTTCTGTGATTCTGGCTGAGCAAGTTCATGCCGGTAGAG
GCTCATTAAGTGAGGTCCTGGGCACCCCCCAAACAGGAAGTGTTTTCAGGCCCTTACATGCTTATCCTTAAGGTGAGTAGGTATCTCAGC
AGCACACCCGAACAGTAAAGGTGATCAATAACGAAACTGTAGTTTTCAGATTGAAGAATGAACCTGGATCACCAAACTAGATACCGAAAG
GGCTCCTCATTTGTCTCTTTTGTCCCATTGTGGGCATATGGTGGGCTCCTTGAGAGGAGGGAGTCTCAGCTGGGGCCTGGCTGCAGAGAC
CTGCTCTTGAATAGGGCTGCCTTTGGGATCAGGGAGCCGAGCATACTGGGCAAGGCTCATCATGTTCCTTTGTGGAAGTGGTTACTTGGT
GGGGGTGGGGTGGGGAAGGGGGGTCTAGGAAGCCGAAGCTGAGTGCGCACTAGAGCTGCTAGCAGGCAGGCCAGAGGGTCAGCTTGTGTT
TTATTTTCTGATTTCTCCTGCATGCTTTCTGGAGATGAGGATTTTTTGTCAGGTAGCTAGGAGAGCACTGCCACCTTGTGTCCATATAGC
ACAATGTTTCTCTTTCCTATTCACAGACAAGATTCAAGAAACCATTTTTACGTGTGTACATTCAAATCTTCATGAATGGCATCACTTGCT
TTAGACCCATTTTTTTTTTATTGGTCAGAAATAAAATGTGACTGCAACTGTGTGCCCTCCCTTGTCGTGAATTCCCTGTTTATCACTTCC
ATGCATGGTTTTATGCTTCTCATTTGTTTATGTATTCATGAATACTGCATAGTCCTGATTCAGAGACTTTTGCTTTGCTTTCCAACTTGT
ATCCCTACATTCTCACAACAGCCTTCTTACCTCGGGTGAGAGTCATGAGCACCTTACCAGGCAGGGAGCTTCCCCAGGATAGTGTGGTGG
AGTCAGGACTCACTCCATCCTGCACTTTACCCACAGGACACCTGGAGGGTCCCCCAGCCCTGCTTGCTTTTGTGAACGTCGTGTGAGTAC
ACCGAGGTGTTGCAGCTTTCCTTCCCTCTAGCTCAGGAGGCCTGGCCTGAGCCAGGTTGGAGCTTAAATTGCTGTTGGCTCCTGCCTGGT
GGAACAAGGGGGTCATAGAAACCAGGGCTGATGGGCACCCCCCAGCCCCTGGGAGCTCTGCTCATGACCGCTCACAGGGTACCGAGTCTT
TGCCTTTTGTGTGTGCGCATGCTGCCCTCTTAACTGCTTTTAGTATTCAGAAAGGTTCCATTTATGTTTTACTCCTGAAAGTGAAACCCT
CTTAGGCAACTTGTTTCATATTCTGGGCATTTTAGTAGCTACAGTATTTTGCATTTAAAATGTAATTACTCTTAGTATTGTACAGCCCTA
TAATGTATGAGAACTAGTTTCACATCCTTTGAAACTAATCTCTTTCATTGGGGAGGATACAACTTTTGACTTTACACAGGTGGACTTTGA
ATCCATTTTTATAGAATTTTTTTCCACTGTAACTTGACCTATATTATGCAAGAAAATCCCAAAAATATGTTTTAAGGGAGACTACACAGA
CCTTGTGATTTGGTCTGAGCTAGTTGCTGAGTTGACTGGAGCCTTATTTGAATGGATCTTTGAGTTGAGATCTTCACACTGTCAGTGAGC
CCTTGGCTCAGCCCTTGTCACCTGTTTGTATGGGGACCATGTTTCCCAAAGCTCAGGTTCATCTCCACTATTGACAGAGTCGGGTAGTGG
GAGAGTATAAGTGACTTGAGACAGAGTGTCCTTGCTCAGAAAACTGTGAAGCAGGGGTCTTGTTAGTTACAAAGCCAGTCCTAGTTGCAT
GTCCAAGGGGGTAGATTTTCATCACCCTACTAAATGTGGTATGTCACTGCTGAAGCCTTTTCCTGTTTTAGTAATATCTTAGGCACTATT
GTCTTTTGTCTTCCAGAGTAACATATCTGGGCCCACCTTTCTTGCACACTGTGATTATGTGCTAAGAAAAGGGTGGAGTTGGGAGGACAA
TTTCACTTGAACAGGTTTCTGTTCTTCTGAGGTCAGGGTGGGGAGGATGTCCAGGTGACTTTTATGGACACATTGCAAGACAGTAAGCCG
CGGATGGACTCTCACTTGTGCTTTGGAACACTGGACTCCAAAGAGCAGGTGGAACAAACTCTGGCCTGAAGATGATGGCTAATACTCAGG
CAGAGCCCCGTATTCTTCCCTGACTTGGTCAAAACAAACTTCCTTTTCCCTTGATCACCCTGCACGCAGCTGCCCAGCTTCCAGTTTTTA
AAGAGATGAACAGCTCTCACTTCCTGACTCAGTTTCTCTTGTTGGGTGGGGGCCTTGTGCCACAACCTGCATGGGGTGCTAGGGTTTAAA
CCAAGTGGTCACGAAGGATTCTTATCTCAGGGCTCTGCCTGGCCCACCTTCTCTTGGGCCTGGACTCTCCTTATCCACATCCCTGCAGAA
GGTGGGCCCTATTCTCAGAAGAGTCCTGGCTGCTGTTGCCATCTGAATGCGCCCTTCCCTTTCAGGTTGACCAGCAGTGGCCTTACCTGG
CCTCTCAGGTGGATGGAGGCTGTTCTCATCTGGGGCTGTCTCTTGATTAAGGCTGTCACCTGTTTGTATAGGGACCATGTTTCCCAACGC
ACTTTGAGTGCAGTTTAGGAGGTATCCTTTGGATGCTGAAGTGTTGGGATTTTGAGGACATGCGGATGATTTATGAGAATAGAGGGGCAG
AGTTTGTGAAGTCTAGGGTTTTTTGTCCAGTGGGTTTCAAATTTGTTGGCTGTTTAAAGACCCTGTCTCCTCCCCCACCCTCCCCTTCCT
TTTCCCATCAAATGCCTACCTACTGAGGCGCCTTCTCTTTTTATTCTTGAGCCAATGAGATATCAGTGTGTTTATTAATAAGGATTGCAA
TAGTATAGTGCTTAATATGTGCCAGGCATAGTGCTAAGGGTTTACATACGTTATCCCTTTTAATCCAGAAAACAGCCTTTGATTAGGTAT
TGTTGTCTCCATTTTATAGATGAGGAAACTGAGGCAGTATGACTGAGGCCGAGAGCAGTGGTTAAGACAGACTTTGGGATCAAATCACCC
TAGGTGCGGGCAGGTTTCTAGGCTGCTCTAAGCTTCTACCTTGAAGGCAGTTGGGTCTGATAATAGTACCTTCTTCCTGGGGTGGTTGTG
AGGATATAACGAGGTAATGCATGTAAGCATTTAGTACCATGCCTGGCACATAGTAAGCACTCAATAAATGGTAGTTACTTTTGTTGAGCT
CAGCTGGTAGTTTGACCTCCGTTGGTGCAATGCCAGAGATGGGATTGTCAGCCACCACACTGCCACCACCCTGCACACAGTCTGGGTCCC
TCCGAGAGAAGCACGCCAACCTTAACATCCCCTACAGCATCTTGGTGCTTCACACACCATTTAGGAGGCCACCCTAACGAGGCAAGAGGA
CATGGGGGTGTGCAGAAGTTCTGTTCTTAGTGAGAATGGCTGGCCTGAGAATCCAGCTCACCTCCTCTGCCCACAGTCTGGACTGCTTGT
GGGAAGGCCATCTCCTCCTGTCTGGTGGTACCTCCACTCTGGGCAGGGAGGGCCTGTCTGTGACTCGCTCTGGACCCCACTTCCCGCTCT
GGCCAAGGGCTGTCTTCTGTGCACATAGCTCAGGAGCCTGCAGCAGTTCCCTGTATGGGTGGATGTCCTCAGGGGCCAAGAAGAGAAGAA
TGGGGACAACAGAAACCTGCTTTGTAGGGGATTATGTAGACTAAAAGCCTAGAAGTTCTGCCCACATCCTTATGACGCAGCCAATCTGGA
GCTTCATGTTTCCTTCTAAAAGTAGTAACCGGGTAGAAGTGGGTGACCCATTGAGGACACATGATGTGAGGTATTTCTGCCGGATTCTAG
GTTAGCAAAGACTCAAATGGGTGACTCATGAATGAAGGGAGAACAGGCACAGGACTTAATGAAAAGAGTTTCTTGAACTTAGTTTTCTGA
ATGGGGGTGGGGAGTTGGGGCACGTGTGTGTAAGGGGAGGCTGCCTCACTTTGAAGGAATGGTGTTGGCTAACAGGATCCATGAAATTCC
TAGGTCAGTTGAATAATAACTGAACTACTGGTTTGACTGTGGATTATTTCCTGGGTATTAGTGGGACCCAACAGCACATTGCTATTAATA
GTATGGAAATAATGGTCCCTCTGTTTCATTGAATTGCTGAAGTAATGATAATGCCATGAACCAGGAGAAGATGGTTGTGGGGGTTTCTAG
GAAGCAGCTGCTGTGACAGGCCAATCCCAGGCTTGCCCCCGAGCCCTCCTGTCCTTCTGGGTTTGTGTTTGCCTTGCCTGGTGCTTCCTC
CCTCATTGTGTTGTTGAATAGACCTAGGCAGCCTTGTATCCATAGAAAGCCTCCACTGCTGGGCCGGGGAGGGGGTTGTGGTAAGGGCCC
TCTGGAAATCAAGCAGAGAATGCCTTTGCAGTGGTCTCCCGGGCATTGGGCAGGGCCTAGCCTTTTGCAGCCCCCAGAGGACCTTGCCTG
CATAAAGCACTCAGAAGGGTTAGCCACCTGGTGATTTTGTCTCTAGTGAAACTGTGTTTGCCGATAATCATCCACATAGCCACCTCTGTC
CTCGCAGTTTGGATGCCTTTTTTTGACACCTGCGCTAGGTTCTTGTATGCTGGCTTTTCTTAAAGGAACAGCAGAGTAGAAAAGAGGTTG
AGAATGTTTTCTAGCAGGCAGAATGTGCATACATGTTTTCATGAGTGTCCTTTGGGTGCTGTTTCTTTTAAATCCTCTGTGCACAGGGCT
CTGGCCTTTAGTAAACTGTTTTTCTGTCTTACGTCATGCTGACTGGGTGCTAGGGGCTGATTACAAAGGGGAAGAGTTGAACAGACATCA
GGGGCCGATGAAACCAAAGGACTAGGAGTCAGGAGAACAAGTCAGGGATTAGGAGACAGCGGTTTGGTTTATTGTTATCCAGCTGGAGGA
CTCCTAGGGGCAGCAGCAGGAGGAATACCAGGGCCACGGAGGGGCCAGGAGTCTCACAGTGGAGGGCAGACTCTAACAGATGCCAGCTGA
ACGCTCGCTGGCCCTGGATGTCATACGAGTTGGGGACCAGAAATCTGGGCTCAGAGAACCCGTCCAGGGAGATTTGAAGCCATGGGTTAT
CTTCTAGAGTTGATACTGATAATATATTTTAATTTTTATTGATGTTTAATACCTTCTGAAACAGGAGGGTAAGATCAGATGGGAAGCCCC
TCTGTTGAAGGATCTTGGGAACCTTGGTGGTTTTTTTTTTTTTTTTGGTTTTTTTTTTTTGATCGAGCTGTGGACATCCTTCTTAATTCG
ATTCTGAGGATTTGTTTAACTAAAAAGTTCCCAAACACAGAAAGGGCCTCCCCACCTGCTTTGGGGAGCTGTCTGTGCTGGGAGTGCCAG
GCATCCCATGGGACCCATCACTGCCAGTGTCTGTGCCTCCCAGAGGTCAGCCGTGTCTGCCCTGGCTCTGTCTCCTCTGTGACAGGGCAG
AGCATTTCTGGTCAGTTTCTCCATGGTGCCTCCCACCCCTTTGTAAAGTGGATGGACATGATGGAATTCAGTTGTCTCACCCTGATAGCC
TGGGTGTTGATATTCACTTTACCCGCACTCAGACACAGGCGACCTTGAAGCAGTTCTCGGTGTGTAGAGTCCACGTGACAGTCCCCACAG
CCTCCCCAGATAGCTGTGTGCCTGTGCGCTACTGCTGTGCCATTTTCCCAACTTGGCGTTTCACTAAATGCAGCTGATCTCTCTCTCTGT
GCACTCGTGATCCATGTTGAACAATACATGTAGGTTCTTTTTCCACGCAATGTAAGAACATGATATACTGTACGTTGGAAAGCATTTACC

>75045_75045_1_RNF24-CDS2_RNF24_chr20_3925824_ENST00000336095_CDS2_chr20_5154169_ENST00000460006_length(amino acids)=539AA_BP=113
MRRDAEEGPARPRDWRVSPSQRAERGCHLEITEGSSSMSSDFPHYNFRMPNIGFQNLPLNIYIVVFGTAIFVFILSLLFCCYLIRLRHQA
HKEFYAYKQVILKEKVKELNLHEESESEAKVDGETASDSESRAESAPLPVSADDTPEVLNRALSNLSSRWKNWWVRGILTLAMIAFFFII
IYLGPMVLMIIVMCVQIKCFHEIITIGYNVYHSYDLPWFRTLSWYFLLCVNYFFYGETVTDYFFTLVQREEPLRILSKYHRFISFTLYLI
GFCMFVLSLVKKHYRLQFYMFGWTHVTLLIVVTQSHLVIHNLFEGMIWFIVPISCVICNDIMAYMFGFFFGRTPLIKLSPKKTWEGFIGG
FFATVVFGLLLSYVMSGYRCFVCPVEYNNDTNSFTVDCEPSDLFRLQEYNIPGVIQSVIGWKTVRMYPFQIHSIALSTFASLIGPFGGFF

--------------------------------------------------------------
>75045_75045_2_RNF24-CDS2_RNF24_chr20_3925824_ENST00000432261_CDS2_chr20_5154169_ENST00000460006_length(transcript)=9225nt_BP=291nt
ATGTTGAATAAGAGTGGTGAGAGCAGATATCCTGCCTTGTTCCCGGTCTTAGGGGGTTCATCCATGAGCTCGGATTTCCCACATTACAAC
TTCAGGATGCCTAATATTGGATTCCAGAATCTGCCTCTCAACATATATATTGTGGTTTTTGGTACTGCTATATTTGTCTTCATCCTTAGT
TTACTCTTCTGTTGCTACTTGATTAGGCTAAGACATCAAGCACACAAAGAATTTTATGCCTACAAACAGGTTATATTAAAAGAGAAAGTA
AAAGAATTGAATTTACATGAGGAGTCAGAGTCAGAAGCAAAGGTAGATGGAGAGACTGCATCGGACAGTGAGAGCCGGGCAGAATCCGCA
CCCCTGCCAGTCTCTGCAGATGATACCCCGGAGGTCCTCAATAGGGCCCTTTCCAACTTGTCTTCAAGATGGAAGAACTGGTGGGTGAGA
GGCATCCTGACTTTGGCCATGATTGCATTTTTCTTCATCATCATTTACCTGGGACCAATGGTTTTGATGATAATCGTGATGTGCGTTCAG
ATTAAGTGTTTCCATGAGATAATCACTATTGGCTACAACGTCTACCACTCATATGATCTGCCCTGGTTCAGGACGCTCAGCTGGTACTTT
CTCCTGTGTGTAAACTATTTCTTCTATGGTGAGACAGTGACGGATTACTTCTTCACCCTGGTCCAGAGAGAAGAGCCTTTGCGGATTCTC
AGTAAATACCACCGGTTCATTTCCTTTACTCTCTATCTAATAGGATTCTGCATGTTTGTACTGAGTCTGGTCAAGAAGCATTATCGACTG
CAGTTCTACATGTTTGGCTGGACCCATGTGACATTGCTGATTGTTGTAACACAGTCACATCTTGTTATCCACAACCTATTTGAAGGAATG
ATCTGGTTCATTGTCCCCATATCTTGTGTGATCTGTAATGACATCATGGCCTATATGTTTGGCTTTTTCTTTGGTCGGACCCCACTCATC
AAGCTGTCCCCGAAGAAGACCTGGGAAGGCTTCATTGGGGGCTTCTTTGCTACTGTGGTGTTTGGCCTTCTGCTGTCCTATGTGATGTCC
GGGTACAGATGCTTTGTCTGCCCTGTGGAGTACAACAATGACACCAACAGCTTCACTGTGGACTGTGAGCCCTCGGACCTGTTTCGCCTG
CAGGAGTACAACATTCCTGGGGTGATCCAGTCAGTCATTGGCTGGAAAACGGTCCGGATGTACCCCTTCCAGATTCACAGCATCGCTCTC
TCCACCTTTGCCTCGCTCATTGGCCCCTTTGGAGGATTCTTCGCAAGTGGATTCAAACGAGCCTTTAAAATCAAAGACTTTGCCAATACC
ATTCCTGGCCATGGAGGCATCATGGATCGCTTTGACTGCCAGTATCTGATGGCCACCTTTGTCAATGTATACATCGCCAGTTTTATCAGA
GGCCCTAACCCAAGCAAACTGATTCAGCAGTTCCTGACTTTACGGCCAGATCAGCAGCTCCACATCTTCAACACGCTGCGGTCTCATCTG
ATCGACAAAGGGATGCTGACATCCACCACAGAGGACGAGTAGGGGCCACCCAGGGCCAGGAGAACAGGAACAGAACTGAGCAGGGGCAGG
TCTCCAAGGCAAGCCCAGCTGGTGTGACTTAGACAATGACGAGGCTTCAACTCACTGTCTTTTTTTTTTTTTTTTGGAGGGTATTTTTTA
TTTGTGGGTTCAAAAAATCTGTATATACAGTCTATGTGTTTAGAATTTGTGTTGTAAGTAAACTACAGCTTTGAGTTGGAAAGAAGTCAC
GGGTTGTAAAACCATTTGGATTTTTTTAAAACAAAAGTATTAATAATCTGGAAGACAGTGTTGCCCAGGTCAGGAGTGTTTTCTTGGTGG
TTCCAGCCCCCATCAATTGAACTGTTTCTGGGCTCAGTCAGACACAGACATTCATCTGTGTCTGACCAAATCAGGGGACTTCCCCACCTG
TGGTGGGAGGCACAGCTTAGATGTTTTGTACACCTGGTCTTTTCTAGAAATCCCTGCTTGGAGCTGCAGAAGGGTTGCCTTCTGTAGGTC
GGAGGAATGGAGGCTTACTAACCAGGTAAGCCTTCTATGCATCCACACCAAAATCCTGCAGAATGTAAGTAAGCTCTGCTTTATAAGATG
GGTTCACCTTCATCGCAGACTGAAAGTTTCAGTTTTTATTTTTTTCAGAAAGCACGAAAAATTATTTATAATAGTCTGGAGAAAAAACAC
ACTGTAATATTTCAAGTGTATGCAGTAGAATGTACTGTAACTGAGCCCTTTCCCACATGTCTAGGCTCCAATGTCTCCTGTAGGTCCACC
TAACTGTGTGTTTTCAGGGACAATGCCATCCATGTTTGTGCTGTAGACTTGCTGCTGCTGAATCCTTTCTGGGGACTTTCTCATCGGGCA
GGGAGCAGAGGGCTTCTCGTTCATGCACCCTTTGCCTGAACACCCATGTAGCTGCTGTGTTGTGTATATATTACTCTTAAGAGGAGTGTG
TGTGTCTGTGTTTGTTTTAAAAGTCACTTATTTCTTACAGTGATTTCAATTGCACCATGACTTCTTCACTAAAACCACAAAGTCCTGCTT
AAAACTATGGAAAACCTAACCTGATTAGAGCCTTGACTATTTTGAAGATTAAATGCACACTTTTTATATAATGTGACCAGTTTAAATGTA
GTTTGTATTGTACTGGGGGACCTTTCGTTGTTGTTGTTTGCTTAAACTGTGATTTTTTTTCCCCTCCCTAATTTCAGGGGTGAGATTGAC
TTTGGGAAGACAGATTAGTTCTTTGTCAGGCCAACAAGTGATGGAGTGCGGGAGAGAGAACTTGGCACCCAAATATATCAAACTATTCCG
TGCCGTGGATGTTTTCATTGCCAACGAGGGTGTAATGATTTGCTTCTGCACCTTGGTCTAGTGCTGGTTTGTGGTGTTTTTGTTTGTAAA
TTAGCCTCACTGCCTCCCTGAAAGTGCACAGTCAGCCCAGGTCTCTAGAGTGTCCAGCAGAGGATGGAGCCCTCGGGATGTTTCAGCTCA
CACATCCTTGAGTGACTTCCCATATGTGTGTGGGGCTGAAGCGGCTTCTTTCCGCTGAACTTTTATTTCCATTTCAGCCTCGTGGCTTCT
CTTATTCAGGTCCAAGGCCCCTTAAAAACAAAACATATTATCGCAAGGGCTTTCATTTCAGTATTGGCTGTGTCACTGGCAGGATGCATC
ACTCTCCAGGGCCTCTTTTTCGGAGCTACTCCCAATTCCACTCTTCTGTGATTCTGGCTGAGCAAGTTCATGCCGGTAGAGGCTCATTAA
GTGAGGTCCTGGGCACCCCCCAAACAGGAAGTGTTTTCAGGCCCTTACATGCTTATCCTTAAGGTGAGTAGGTATCTCAGCAGCACACCC
GAACAGTAAAGGTGATCAATAACGAAACTGTAGTTTTCAGATTGAAGAATGAACCTGGATCACCAAACTAGATACCGAAAGGGCTCCTCA
TTTGTCTCTTTTGTCCCATTGTGGGCATATGGTGGGCTCCTTGAGAGGAGGGAGTCTCAGCTGGGGCCTGGCTGCAGAGACCTGCTCTTG
AATAGGGCTGCCTTTGGGATCAGGGAGCCGAGCATACTGGGCAAGGCTCATCATGTTCCTTTGTGGAAGTGGTTACTTGGTGGGGGTGGG
GTGGGGAAGGGGGGTCTAGGAAGCCGAAGCTGAGTGCGCACTAGAGCTGCTAGCAGGCAGGCCAGAGGGTCAGCTTGTGTTTTATTTTCT
GATTTCTCCTGCATGCTTTCTGGAGATGAGGATTTTTTGTCAGGTAGCTAGGAGAGCACTGCCACCTTGTGTCCATATAGCACAATGTTT
CTCTTTCCTATTCACAGACAAGATTCAAGAAACCATTTTTACGTGTGTACATTCAAATCTTCATGAATGGCATCACTTGCTTTAGACCCA
TTTTTTTTTTATTGGTCAGAAATAAAATGTGACTGCAACTGTGTGCCCTCCCTTGTCGTGAATTCCCTGTTTATCACTTCCATGCATGGT
TTTATGCTTCTCATTTGTTTATGTATTCATGAATACTGCATAGTCCTGATTCAGAGACTTTTGCTTTGCTTTCCAACTTGTATCCCTACA
TTCTCACAACAGCCTTCTTACCTCGGGTGAGAGTCATGAGCACCTTACCAGGCAGGGAGCTTCCCCAGGATAGTGTGGTGGAGTCAGGAC
TCACTCCATCCTGCACTTTACCCACAGGACACCTGGAGGGTCCCCCAGCCCTGCTTGCTTTTGTGAACGTCGTGTGAGTACACCGAGGTG
TTGCAGCTTTCCTTCCCTCTAGCTCAGGAGGCCTGGCCTGAGCCAGGTTGGAGCTTAAATTGCTGTTGGCTCCTGCCTGGTGGAACAAGG
GGGTCATAGAAACCAGGGCTGATGGGCACCCCCCAGCCCCTGGGAGCTCTGCTCATGACCGCTCACAGGGTACCGAGTCTTTGCCTTTTG
TGTGTGCGCATGCTGCCCTCTTAACTGCTTTTAGTATTCAGAAAGGTTCCATTTATGTTTTACTCCTGAAAGTGAAACCCTCTTAGGCAA
CTTGTTTCATATTCTGGGCATTTTAGTAGCTACAGTATTTTGCATTTAAAATGTAATTACTCTTAGTATTGTACAGCCCTATAATGTATG
AGAACTAGTTTCACATCCTTTGAAACTAATCTCTTTCATTGGGGAGGATACAACTTTTGACTTTACACAGGTGGACTTTGAATCCATTTT
TATAGAATTTTTTTCCACTGTAACTTGACCTATATTATGCAAGAAAATCCCAAAAATATGTTTTAAGGGAGACTACACAGACCTTGTGAT
TTGGTCTGAGCTAGTTGCTGAGTTGACTGGAGCCTTATTTGAATGGATCTTTGAGTTGAGATCTTCACACTGTCAGTGAGCCCTTGGCTC
AGCCCTTGTCACCTGTTTGTATGGGGACCATGTTTCCCAAAGCTCAGGTTCATCTCCACTATTGACAGAGTCGGGTAGTGGGAGAGTATA
AGTGACTTGAGACAGAGTGTCCTTGCTCAGAAAACTGTGAAGCAGGGGTCTTGTTAGTTACAAAGCCAGTCCTAGTTGCATGTCCAAGGG
GGTAGATTTTCATCACCCTACTAAATGTGGTATGTCACTGCTGAAGCCTTTTCCTGTTTTAGTAATATCTTAGGCACTATTGTCTTTTGT
CTTCCAGAGTAACATATCTGGGCCCACCTTTCTTGCACACTGTGATTATGTGCTAAGAAAAGGGTGGAGTTGGGAGGACAATTTCACTTG
AACAGGTTTCTGTTCTTCTGAGGTCAGGGTGGGGAGGATGTCCAGGTGACTTTTATGGACACATTGCAAGACAGTAAGCCGCGGATGGAC
TCTCACTTGTGCTTTGGAACACTGGACTCCAAAGAGCAGGTGGAACAAACTCTGGCCTGAAGATGATGGCTAATACTCAGGCAGAGCCCC
GTATTCTTCCCTGACTTGGTCAAAACAAACTTCCTTTTCCCTTGATCACCCTGCACGCAGCTGCCCAGCTTCCAGTTTTTAAAGAGATGA
ACAGCTCTCACTTCCTGACTCAGTTTCTCTTGTTGGGTGGGGGCCTTGTGCCACAACCTGCATGGGGTGCTAGGGTTTAAACCAAGTGGT
CACGAAGGATTCTTATCTCAGGGCTCTGCCTGGCCCACCTTCTCTTGGGCCTGGACTCTCCTTATCCACATCCCTGCAGAAGGTGGGCCC
TATTCTCAGAAGAGTCCTGGCTGCTGTTGCCATCTGAATGCGCCCTTCCCTTTCAGGTTGACCAGCAGTGGCCTTACCTGGCCTCTCAGG
TGGATGGAGGCTGTTCTCATCTGGGGCTGTCTCTTGATTAAGGCTGTCACCTGTTTGTATAGGGACCATGTTTCCCAACGCACTTTGAGT
GCAGTTTAGGAGGTATCCTTTGGATGCTGAAGTGTTGGGATTTTGAGGACATGCGGATGATTTATGAGAATAGAGGGGCAGAGTTTGTGA
AGTCTAGGGTTTTTTGTCCAGTGGGTTTCAAATTTGTTGGCTGTTTAAAGACCCTGTCTCCTCCCCCACCCTCCCCTTCCTTTTCCCATC
AAATGCCTACCTACTGAGGCGCCTTCTCTTTTTATTCTTGAGCCAATGAGATATCAGTGTGTTTATTAATAAGGATTGCAATAGTATAGT
GCTTAATATGTGCCAGGCATAGTGCTAAGGGTTTACATACGTTATCCCTTTTAATCCAGAAAACAGCCTTTGATTAGGTATTGTTGTCTC
CATTTTATAGATGAGGAAACTGAGGCAGTATGACTGAGGCCGAGAGCAGTGGTTAAGACAGACTTTGGGATCAAATCACCCTAGGTGCGG
GCAGGTTTCTAGGCTGCTCTAAGCTTCTACCTTGAAGGCAGTTGGGTCTGATAATAGTACCTTCTTCCTGGGGTGGTTGTGAGGATATAA
CGAGGTAATGCATGTAAGCATTTAGTACCATGCCTGGCACATAGTAAGCACTCAATAAATGGTAGTTACTTTTGTTGAGCTCAGCTGGTA
GTTTGACCTCCGTTGGTGCAATGCCAGAGATGGGATTGTCAGCCACCACACTGCCACCACCCTGCACACAGTCTGGGTCCCTCCGAGAGA
AGCACGCCAACCTTAACATCCCCTACAGCATCTTGGTGCTTCACACACCATTTAGGAGGCCACCCTAACGAGGCAAGAGGACATGGGGGT
GTGCAGAAGTTCTGTTCTTAGTGAGAATGGCTGGCCTGAGAATCCAGCTCACCTCCTCTGCCCACAGTCTGGACTGCTTGTGGGAAGGCC
ATCTCCTCCTGTCTGGTGGTACCTCCACTCTGGGCAGGGAGGGCCTGTCTGTGACTCGCTCTGGACCCCACTTCCCGCTCTGGCCAAGGG
CTGTCTTCTGTGCACATAGCTCAGGAGCCTGCAGCAGTTCCCTGTATGGGTGGATGTCCTCAGGGGCCAAGAAGAGAAGAATGGGGACAA
CAGAAACCTGCTTTGTAGGGGATTATGTAGACTAAAAGCCTAGAAGTTCTGCCCACATCCTTATGACGCAGCCAATCTGGAGCTTCATGT
TTCCTTCTAAAAGTAGTAACCGGGTAGAAGTGGGTGACCCATTGAGGACACATGATGTGAGGTATTTCTGCCGGATTCTAGGTTAGCAAA
GACTCAAATGGGTGACTCATGAATGAAGGGAGAACAGGCACAGGACTTAATGAAAAGAGTTTCTTGAACTTAGTTTTCTGAATGGGGGTG
GGGAGTTGGGGCACGTGTGTGTAAGGGGAGGCTGCCTCACTTTGAAGGAATGGTGTTGGCTAACAGGATCCATGAAATTCCTAGGTCAGT
TGAATAATAACTGAACTACTGGTTTGACTGTGGATTATTTCCTGGGTATTAGTGGGACCCAACAGCACATTGCTATTAATAGTATGGAAA
TAATGGTCCCTCTGTTTCATTGAATTGCTGAAGTAATGATAATGCCATGAACCAGGAGAAGATGGTTGTGGGGGTTTCTAGGAAGCAGCT
GCTGTGACAGGCCAATCCCAGGCTTGCCCCCGAGCCCTCCTGTCCTTCTGGGTTTGTGTTTGCCTTGCCTGGTGCTTCCTCCCTCATTGT
GTTGTTGAATAGACCTAGGCAGCCTTGTATCCATAGAAAGCCTCCACTGCTGGGCCGGGGAGGGGGTTGTGGTAAGGGCCCTCTGGAAAT
CAAGCAGAGAATGCCTTTGCAGTGGTCTCCCGGGCATTGGGCAGGGCCTAGCCTTTTGCAGCCCCCAGAGGACCTTGCCTGCATAAAGCA
CTCAGAAGGGTTAGCCACCTGGTGATTTTGTCTCTAGTGAAACTGTGTTTGCCGATAATCATCCACATAGCCACCTCTGTCCTCGCAGTT
TGGATGCCTTTTTTTGACACCTGCGCTAGGTTCTTGTATGCTGGCTTTTCTTAAAGGAACAGCAGAGTAGAAAAGAGGTTGAGAATGTTT
TCTAGCAGGCAGAATGTGCATACATGTTTTCATGAGTGTCCTTTGGGTGCTGTTTCTTTTAAATCCTCTGTGCACAGGGCTCTGGCCTTT
AGTAAACTGTTTTTCTGTCTTACGTCATGCTGACTGGGTGCTAGGGGCTGATTACAAAGGGGAAGAGTTGAACAGACATCAGGGGCCGAT
GAAACCAAAGGACTAGGAGTCAGGAGAACAAGTCAGGGATTAGGAGACAGCGGTTTGGTTTATTGTTATCCAGCTGGAGGACTCCTAGGG
GCAGCAGCAGGAGGAATACCAGGGCCACGGAGGGGCCAGGAGTCTCACAGTGGAGGGCAGACTCTAACAGATGCCAGCTGAACGCTCGCT
GGCCCTGGATGTCATACGAGTTGGGGACCAGAAATCTGGGCTCAGAGAACCCGTCCAGGGAGATTTGAAGCCATGGGTTATCTTCTAGAG
TTGATACTGATAATATATTTTAATTTTTATTGATGTTTAATACCTTCTGAAACAGGAGGGTAAGATCAGATGGGAAGCCCCTCTGTTGAA
GGATCTTGGGAACCTTGGTGGTTTTTTTTTTTTTTTTGGTTTTTTTTTTTTGATCGAGCTGTGGACATCCTTCTTAATTCGATTCTGAGG
ATTTGTTTAACTAAAAAGTTCCCAAACACAGAAAGGGCCTCCCCACCTGCTTTGGGGAGCTGTCTGTGCTGGGAGTGCCAGGCATCCCAT
GGGACCCATCACTGCCAGTGTCTGTGCCTCCCAGAGGTCAGCCGTGTCTGCCCTGGCTCTGTCTCCTCTGTGACAGGGCAGAGCATTTCT
GGTCAGTTTCTCCATGGTGCCTCCCACCCCTTTGTAAAGTGGATGGACATGATGGAATTCAGTTGTCTCACCCTGATAGCCTGGGTGTTG
ATATTCACTTTACCCGCACTCAGACACAGGCGACCTTGAAGCAGTTCTCGGTGTGTAGAGTCCACGTGACAGTCCCCACAGCCTCCCCAG
ATAGCTGTGTGCCTGTGCGCTACTGCTGTGCCATTTTCCCAACTTGGCGTTTCACTAAATGCAGCTGATCTCTCTCTCTGTGCACTCGTG
ATCCATGTTGAACAATACATGTAGGTTCTTTTTCCACGCAATGTAAGAACATGATATACTGTACGTTGGAAAGCATTTACCTTATTTATA

>75045_75045_2_RNF24-CDS2_RNF24_chr20_3925824_ENST00000432261_CDS2_chr20_5154169_ENST00000460006_length(amino acids)=523AA_BP=97
MLNKSGESRYPALFPVLGGSSMSSDFPHYNFRMPNIGFQNLPLNIYIVVFGTAIFVFILSLLFCCYLIRLRHQAHKEFYAYKQVILKEKV
KELNLHEESESEAKVDGETASDSESRAESAPLPVSADDTPEVLNRALSNLSSRWKNWWVRGILTLAMIAFFFIIIYLGPMVLMIIVMCVQ
IKCFHEIITIGYNVYHSYDLPWFRTLSWYFLLCVNYFFYGETVTDYFFTLVQREEPLRILSKYHRFISFTLYLIGFCMFVLSLVKKHYRL
QFYMFGWTHVTLLIVVTQSHLVIHNLFEGMIWFIVPISCVICNDIMAYMFGFFFGRTPLIKLSPKKTWEGFIGGFFATVVFGLLLSYVMS
GYRCFVCPVEYNNDTNSFTVDCEPSDLFRLQEYNIPGVIQSVIGWKTVRMYPFQIHSIALSTFASLIGPFGGFFASGFKRAFKIKDFANT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RNF24-CDS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RNF24-CDS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RNF24-CDS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource