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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATG10-FBXO38 (FusionGDB2 ID:7507)

Fusion Gene Summary for ATG10-FBXO38

check button Fusion gene summary
Fusion gene informationFusion gene name: ATG10-FBXO38
Fusion gene ID: 7507
HgeneTgene
Gene symbol

ATG10

FBXO38

Gene ID

83734

81545

Gene nameautophagy related 10F-box protein 38
SynonymsAPG10|APG10L|pp12616Fbx38|HMN2D|MOKA|SP329
Cytomap

5q14.1-q14.2

5q32

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-like-conjugating enzyme ATG10APG10 autophagy 10-likeATG10 autophagy related 10 homologautophagy-related protein 10F-box only protein 38modulator of KLF7 activity homolog
Modification date2020031320200313
UniProtAcc

Q9H0Y0

Q6PIJ6

Ensembl transtripts involved in fusion geneENST00000282185, ENST00000355178, 
ENST00000458350, ENST00000513443, 
ENST00000513634, ENST00000514253, 
ENST00000509699, ENST00000513826, 
ENST00000296701, ENST00000340253, 
ENST00000394370, 
Fusion gene scores* DoF score8 X 6 X 6=2888 X 6 X 7=336
# samples 88
** MAII scorelog2(8/288*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATG10 [Title/Abstract] AND FBXO38 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATG10(81354421)-FBXO38(147812987), # samples:1
Anticipated loss of major functional domain due to fusion event.ATG10-FBXO38 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATG10

GO:0032446

protein modification by small protein conjugation

16963840

TgeneFBXO38

GO:0002842

positive regulation of T cell mediated immune response to tumor cell

30487606

TgeneFBXO38

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

30487606

TgeneFBXO38

GO:0070936

protein K48-linked ubiquitination

30487606


check buttonFusion gene breakpoints across ATG10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FBXO38 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-IN-7808-01AATG10chr5

81354421

+FBXO38chr5

147812987

+


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Fusion Gene ORF analysis for ATG10-FBXO38

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000282185ENST00000509699ATG10chr5

81354421

+FBXO38chr5

147812987

+
5CDS-intronENST00000282185ENST00000513826ATG10chr5

81354421

+FBXO38chr5

147812987

+
5CDS-intronENST00000355178ENST00000509699ATG10chr5

81354421

+FBXO38chr5

147812987

+
5CDS-intronENST00000355178ENST00000513826ATG10chr5

81354421

+FBXO38chr5

147812987

+
5CDS-intronENST00000458350ENST00000509699ATG10chr5

81354421

+FBXO38chr5

147812987

+
5CDS-intronENST00000458350ENST00000513826ATG10chr5

81354421

+FBXO38chr5

147812987

+
5CDS-intronENST00000513443ENST00000509699ATG10chr5

81354421

+FBXO38chr5

147812987

+
5CDS-intronENST00000513443ENST00000513826ATG10chr5

81354421

+FBXO38chr5

147812987

+
5CDS-intronENST00000513634ENST00000509699ATG10chr5

81354421

+FBXO38chr5

147812987

+
5CDS-intronENST00000513634ENST00000513826ATG10chr5

81354421

+FBXO38chr5

147812987

+
Frame-shiftENST00000282185ENST00000296701ATG10chr5

81354421

+FBXO38chr5

147812987

+
Frame-shiftENST00000282185ENST00000340253ATG10chr5

81354421

+FBXO38chr5

147812987

+
Frame-shiftENST00000282185ENST00000394370ATG10chr5

81354421

+FBXO38chr5

147812987

+
Frame-shiftENST00000355178ENST00000296701ATG10chr5

81354421

+FBXO38chr5

147812987

+
Frame-shiftENST00000355178ENST00000340253ATG10chr5

81354421

+FBXO38chr5

147812987

+
Frame-shiftENST00000355178ENST00000394370ATG10chr5

81354421

+FBXO38chr5

147812987

+
Frame-shiftENST00000458350ENST00000296701ATG10chr5

81354421

+FBXO38chr5

147812987

+
Frame-shiftENST00000458350ENST00000340253ATG10chr5

81354421

+FBXO38chr5

147812987

+
Frame-shiftENST00000458350ENST00000394370ATG10chr5

81354421

+FBXO38chr5

147812987

+
Frame-shiftENST00000513443ENST00000296701ATG10chr5

81354421

+FBXO38chr5

147812987

+
Frame-shiftENST00000513443ENST00000340253ATG10chr5

81354421

+FBXO38chr5

147812987

+
Frame-shiftENST00000513443ENST00000394370ATG10chr5

81354421

+FBXO38chr5

147812987

+
Frame-shiftENST00000513634ENST00000296701ATG10chr5

81354421

+FBXO38chr5

147812987

+
Frame-shiftENST00000513634ENST00000340253ATG10chr5

81354421

+FBXO38chr5

147812987

+
Frame-shiftENST00000513634ENST00000394370ATG10chr5

81354421

+FBXO38chr5

147812987

+
intron-3CDSENST00000514253ENST00000296701ATG10chr5

81354421

+FBXO38chr5

147812987

+
intron-3CDSENST00000514253ENST00000340253ATG10chr5

81354421

+FBXO38chr5

147812987

+
intron-3CDSENST00000514253ENST00000394370ATG10chr5

81354421

+FBXO38chr5

147812987

+
intron-intronENST00000514253ENST00000509699ATG10chr5

81354421

+FBXO38chr5

147812987

+
intron-intronENST00000514253ENST00000513826ATG10chr5

81354421

+FBXO38chr5

147812987

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ATG10-FBXO38


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATG10chr581354421+FBXO38chr5147812986+7.47E-050.99992526
ATG10chr581354421+FBXO38chr5147812986+7.47E-050.99992526

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ATG10-FBXO38


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:81354421/:147812987)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATG10

Q9H0Y0

FBXO38

Q6PIJ6

FUNCTION: E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis. {ECO:0000250, ECO:0000269|PubMed:21367888}.FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606). Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606). May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (By similarity). {ECO:0000250|UniProtKB:Q8BMI0, ECO:0000269|PubMed:30487606}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ATG10-FBXO38


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ATG10-FBXO38


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATG10-FBXO38


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATG10-FBXO38


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource