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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:RNGTT-AHI1 (FusionGDB2 ID:75146)

Fusion Gene Summary for RNGTT-AHI1

Fusion gene summary

Fusion gene information	Fusion gene name: RNGTT-AHI1
	Fusion gene ID: 75146
		Hgene	Tgene
	Gene symbol	RNGTT	AHI1
	Gene ID	8732	54806
	Gene name	RNA guanylyltransferase and 5'-phosphatase	Abelson helper integration site 1
	Synonyms	CAP1A\|HCE\|HCE1\|hCAP	AHI-1\|JBTS3\|ORF1\|dJ71N10.1
	Cytomap	6q15	6q23.3
	Type of gene	protein-coding	protein-coding
	Description	mRNA-capping enzymeHCAP1	jouberinabelson helper integration site 1 protein homologcontatins SH3 and WD40 domains
	Modification date	20200313	20200313
	UniProtAcc	.	Q8N157
	Ensembl transtripts involved in fusion gene	ENST00000265607, ENST00000369475, ENST00000369485, ENST00000538899,	ENST00000417892, ENST00000327035, ENST00000367798, ENST00000488690, ENST00000528103, ENST00000531527, ENST00000534469, ENST00000457866, ENST00000367800,
Fusion gene scores	* DoF score	14 X 13 X 5=910	9 X 10 X 7=630
	# samples	15	10
	** MAII score	log2(15/910*10)=-2.60090404459018 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/630*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RNGTT [Title/Abstract] AND AHI1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RNGTT(89479493)-AHI1(135606785), # samples:2
Anticipated loss of major functional domain due to fusion event.	RNGTT-AHI1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. RNGTT-AHI1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RNGTT	GO:0006370	7-methylguanosine mRNA capping	9473487
Hgene	RNGTT	GO:0006396	RNA processing	21636784

Fusion gene breakpoints across RNGTT (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across AHI1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-EE-A2A0-06A	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-

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Fusion Gene ORF analysis for RNGTT-AHI1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000265607	ENST00000417892	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
5CDS-3UTR	ENST00000369475	ENST00000417892	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
5CDS-3UTR	ENST00000369485	ENST00000417892	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
5CDS-3UTR	ENST00000538899	ENST00000417892	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
5CDS-intron	ENST00000265607	ENST00000327035	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
5CDS-intron	ENST00000265607	ENST00000367798	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
5CDS-intron	ENST00000265607	ENST00000488690	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
5CDS-intron	ENST00000265607	ENST00000528103	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
5CDS-intron	ENST00000265607	ENST00000531527	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
5CDS-intron	ENST00000265607	ENST00000534469	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
5CDS-intron	ENST00000369475	ENST00000327035	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
5CDS-intron	ENST00000369475	ENST00000367798	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
5CDS-intron	ENST00000369475	ENST00000488690	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
5CDS-intron	ENST00000369475	ENST00000528103	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
5CDS-intron	ENST00000369475	ENST00000531527	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
5CDS-intron	ENST00000369475	ENST00000534469	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
5CDS-intron	ENST00000369485	ENST00000327035	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
5CDS-intron	ENST00000369485	ENST00000367798	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
5CDS-intron	ENST00000369485	ENST00000488690	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
5CDS-intron	ENST00000369485	ENST00000528103	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
5CDS-intron	ENST00000369485	ENST00000531527	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
5CDS-intron	ENST00000369485	ENST00000534469	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
5CDS-intron	ENST00000538899	ENST00000327035	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
5CDS-intron	ENST00000538899	ENST00000367798	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
5CDS-intron	ENST00000538899	ENST00000488690	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
5CDS-intron	ENST00000538899	ENST00000528103	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
5CDS-intron	ENST00000538899	ENST00000531527	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
5CDS-intron	ENST00000538899	ENST00000534469	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
Frame-shift	ENST00000265607	ENST00000457866	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
Frame-shift	ENST00000369475	ENST00000457866	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
Frame-shift	ENST00000369485	ENST00000457866	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
Frame-shift	ENST00000538899	ENST00000367800	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
Frame-shift	ENST00000538899	ENST00000457866	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
In-frame	ENST00000265607	ENST00000367800	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
In-frame	ENST00000369475	ENST00000367800	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-
In-frame	ENST00000369485	ENST00000367800	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000369485	RNGTT	chr6	89479493	-	ENST00000367800	AHI1	chr6	135606785	-	3742	1626	151	1647	498
ENST00000265607	RNGTT	chr6	89479493	-	ENST00000367800	AHI1	chr6	135606785	-	3706	1590	184	1611	475
ENST00000369475	RNGTT	chr6	89479493	-	ENST00000367800	AHI1	chr6	135606785	-	3707	1591	116	1612	498

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000369485	ENST00000367800	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-	7.58E-05	0.9999242
ENST00000265607	ENST00000367800	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-	9.62E-05	0.9999038
ENST00000369475	ENST00000367800	RNGTT	chr6	89479493	-	AHI1	chr6	135606785	-	7.59E-05	0.99992406

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Fusion Genomic Features for RNGTT-AHI1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RNGTT-AHI1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:89479493/chr6:135606785)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	AHI1 Q8N157
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development (PubMed:21623382). {ECO:0000250\|UniProtKB:Q8K3E5, ECO:0000269\|PubMed:21623382}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RNGTT

chr6:89479493

chr6:135606785

ENST00000265607

195_205

456

575.0

Compositional bias

Note=Asp/Glu-rich

Hgene

RNGTT

chr6:89479493

chr6:135606785

ENST00000369485

195_205

479

598.0

Compositional bias

Note=Asp/Glu-rich

Hgene

RNGTT

chr6:89479493

chr6:135606785

ENST00000265607

25_183

456

575.0

Domain

Tyrosine-protein phosphatase

Hgene

RNGTT

chr6:89479493

chr6:135606785

ENST00000369485

25_183

479

598.0

Domain

Tyrosine-protein phosphatase

Hgene

RNGTT

chr6:89479493

chr6:135606785

ENST00000265607

343_345

456

575.0

Nucleotide binding

GTP

Hgene

RNGTT

chr6:89479493

chr6:135606785

ENST00000369485

343_345

479

598.0

Nucleotide binding

GTP

Hgene

RNGTT

chr6:89479493

chr6:135606785

ENST00000369485

458_460

479

598.0

Nucleotide binding

GTP

Hgene

RNGTT

chr6:89479493

chr6:135606785

ENST00000265607

1_212

456

575.0

Region

Note=TPase

Hgene

RNGTT

chr6:89479493

chr6:135606785

ENST00000369485

1_212

479

598.0

Region

Note=TPase

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000327035

13_45

1054.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000327035

234_239

1054.0

Compositional bias

Note=Poly-Lys

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000327035

1051_1111

1054.0

Domain

SH3

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000327035

607_649

1054.0

Repeat

Note=WD 1

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000327035

652_691

1054.0

Repeat

Note=WD 2

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000327035

695_735

1054.0

Repeat

Note=WD 3

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000327035

742_781

1054.0

Repeat

Note=WD 4

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000327035

797_837

1054.0

Repeat

Note=WD 5

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000327035

841_880

1054.0

Repeat

Note=WD 6

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000327035

885_926

1054.0

Repeat

Note=WD 7

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RNGTT

chr6:89479493

chr6:135606785

ENST00000265607

458_460

456

575.0

Nucleotide binding

GTP

Hgene

RNGTT

chr6:89479493

chr6:135606785

ENST00000265607

528_533

456

575.0

Nucleotide binding

GTP

Hgene

RNGTT

chr6:89479493

chr6:135606785

ENST00000369485

528_533

479

598.0

Nucleotide binding

GTP

Hgene

RNGTT

chr6:89479493

chr6:135606785

ENST00000265607

229_597

456

575.0

Region

Note=GTase

Hgene

RNGTT

chr6:89479493

chr6:135606785

ENST00000369485

229_597

479

598.0

Region

Note=GTase

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000367800

13_45

1196

1197.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000457866

13_45

1196

1197.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000367800

234_239

1196

1197.0

Compositional bias

Note=Poly-Lys

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000457866

234_239

1196

1197.0

Compositional bias

Note=Poly-Lys

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000367800

1051_1111

1196

1197.0

Domain

SH3

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000457866

1051_1111

1196

1197.0

Domain

SH3

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000367800

607_649

1196

1197.0

Repeat

Note=WD 1

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000367800

652_691

1196

1197.0

Repeat

Note=WD 2

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000367800

695_735

1196

1197.0

Repeat

Note=WD 3

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000367800

742_781

1196

1197.0

Repeat

Note=WD 4

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000367800

797_837

1196

1197.0

Repeat

Note=WD 5

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000367800

841_880

1196

1197.0

Repeat

Note=WD 6

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000367800

885_926

1196

1197.0

Repeat

Note=WD 7

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000457866

607_649

1196

1197.0

Repeat

Note=WD 1

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000457866

652_691

1196

1197.0

Repeat

Note=WD 2

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000457866

695_735

1196

1197.0

Repeat

Note=WD 3

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000457866

742_781

1196

1197.0

Repeat

Note=WD 4

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000457866

797_837

1196

1197.0

Repeat

Note=WD 5

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000457866

841_880

1196

1197.0

Repeat

Note=WD 6

Tgene

AHI1

chr6:89479493

chr6:135606785

ENST00000457866

885_926

1196

1197.0

Repeat

Note=WD 7

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Fusion Gene Sequence for RNGTT-AHI1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>75146_75146_1_RNGTT-AHI1_RNGTT_chr6_89479493_ENST00000265607_AHI1_chr6_135606785_ENST00000367800_length(transcript)=3706nt_BP=1590nt
GAAGTTGCGGTGCATTGTGGGTTCTCCTGGAGCTGTGGAGTTGATCCTGAATGAAAGTGGCGCGCCGCCCCTGACGTTACCCGGATCGGA
GAGGTTGGAATTCAGATTACGGCTGCGATTCGGGTGTCTCGGACCCCGGTGTGCACCGGACCACGGGGAGGCGGCTCCAAAGGCGCGGTG
AACGTTGGTGAGGGAGGGCAGCTCTGCGCAGCCCCAAGACATGGCTCACAACAAGATCCCGCCGCGGTGGCTGAACTGTCCCCGGCGCGG
CCAGCCGGTGGCAGGAAGATTCTTACCTCTGAAGACAATGTTAGGACCAAGATATGATAGTCAAGTTGCTGAAGAAAATCGGTTCCATCC
CAGCATGCTCTCAAATTACCTAAAGAGCCTAAAGGTTAAAATGGGCTTGTTGGTGGACCTGACAAATACTTCAAGGTTCTATGACCGAAA
TGACATAGAAAAAGAAGGAATCAAATATATAAAACTTCAGTGTAAAGGACATGGTGAGTGCCCTACCACTGAGAATACTGAGACCTTTAT
TCGTCTGTGTGAGCGGTTTAATGAAAGAAATCCACCTGAACTTATAGGTGTTCATTGTACTCATGGCTTCAATCGCACTGGTTTCCTCAT
ATGTGCCTTTTTGGTGGAGAAAATGGATTGGAGTATCGAAGCAGCAGTTGCTACTTTTGCCCAAGCCAGACCACCAGGAATCTACAAGGG
TGATTATTTGAAGGAACTTTTTCGTCGGTATGGTGACATAGAGGAAGCACCACCCCCACCTCTATTGCCAGATTGGTGTTTTGAGGATGA
TGAAGACGAAGATGAGGATGAGGATGGAAAGAAGGAATCAGAACCCGGGTCAAGTGCTTCTTTTGGCAAAAGGAGAAAAGAACGGTTAAA
ACTGGGCGCTATTTTCTTGGAAGGTGTTACTGTTAAAGGTGTAACTCAAGTAACAACACAACCAAAGTTAGGAGAGGTACAGCAGAAGTG
TCATCAATTCTGTGGCTGGGAAGGGTCTGGATTCCCTGGAGCACAGCCTGTTTCCATGGACAAGCAAAATATTAAACTTTTAGACCTGAA
GCCATACAAAGTAAGCTGGAAAGCAGATGGTACTCGGTACATGATGTTGATTGATGGCACAAATGAAGTTTTTATGATTGATAGAGACAA
TTCAGTATTTCATGTTTCAAATCTGGAATTTCCATTTCGTAAAGATCTTCGTATGCATTTATCAAATACTCTCTTGGATGGCGAGATGAT
TATTGACAGAGTAAATGGACAGGCTGTTCCTAGATATTTGATATATGACATAATTAAATTCAATTCACAGCCCGTTGGAGATTGTGATTT
TAATGTTCGTCTGCAGTGTATAGAACGAGAAATTATAAGTCCTCGACACGAAAAAATGAAGACTGGGCTCATTGACAAAACACAGGAACC
ATTTAGCGTCAGAAATAAGCCGTTTTTTGACATCTGTACTTCAAGAAAGAAATACAAACCTGGTCGATGTGATGATATTTTGAAATGGAA
GCCTCCCAGTCTGAATTCTGTGGATTTTCGTCTAAAAATAACAAGAATGGGAGGAGAAGGTAAAGAATTGAAGAAAAGTTAAGAGCTGCC
GAAATGCACAGAGGTGAAAATGACAAACCAAATGGAATTTCTCTTCAGAGTTCAGAATTTTCAGATACTAAGGAGGAAGAAAGGATCCAC
TACTTCTTGTTCTTATGAATGACTCTAGAAAAATCAGAATCAAGTTGTGGGTGGAAAAATCAACGTGGCCTTTGAGTTCAGTTGTTATAA
ACCATTGTGACTATTGTTGGTCAAAGTATTGGTACTTATATTGTTAGTAATTGCATCATAATTACATTACCAGTGTTGGAAAACTAATGA
AGAAAACACTGTAATTGCTACTCAGCAAATGTGAATAAAAGGTGTTTGCGTTATTAGGATGTCTGTTAAGTAATCATTTAATATTATTAT
ATTGGTAATGGTTGTATGTGTGATGCTATGCCCAGAATATGAAGTATCTGTTTTTGAAATTCACTTTATTTAAAAGATAAGCAGCTGACT
GGGCACGGTGCCTCATGCCTGTAATCCTAGCACCTTGGGAGGCTGAGGCAGGTGGATCACCTAAGGTCAGGAGTTCAACAACACCAGCCT
GACCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATCAGCCGGGTCTCATGGCAGGCACCTGTAATCCCATCTACTGAGGCAG
GAGAATTGCTTGACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATCACGCCATTGCACTCCAGCCTGGGGGACAGAGCAAGACTCTATCT
CCAAAAAACAAAAAAGATAAGCAGCTTTAGAATATGGCGCATTCAAAACAGTCTCAGTAACAAAGACATTAAAAGAAAACAATTTACTTT
CTAATTAAAATTTTGTGTTTCTTAAGATCAAATCATATAGGTAACTTCATAGACCTAAATTAAAAGTGATTTTTGGCTGGACTGGCAACA
ATGTTCCCAATGTCTTTACTTTTTAAAAAAGGCTTTTCATATTTAAGCACATACCTATTTTGTAGACTTACATTGTTTAATATTTATTTT
AATCTTAATATTTTTACATTATTATATTGCATTATTTATTTTTTCTAAGTTCCAGAATAATAGTGTCATTATTATAGACTATATGTTTTG
AAGTTTGATATTATAATGGGATATTCATTTTTTGTTCTTTTCTTGACTCCTTTCTCAAGTGTGTGATAAGGTCTGCTGATAAAATATTTA
ACCCCAAGAAAGTGAAAACTAATATAAAATTAGAAAGACCTATCCAAATTAGACAGTCAATTCCATTAAAATAAGAAGTGAGAAAAACAA
TGTTGGGCATTGAGGTGTAAATTTTGCCCAGATGTATACCCAGTGTGAAATATCTTCTAATAAAAATATATTTGGCTCTTATCCCTGCAC
ATGTAGAGGCATAAAAATTGGTAAACATGTCCCGCTGTGTAGAACTTTAAAAAAAAGGCATTTTTGAAAGTGTTGAGTGGCACTGATAAC
TGGTGAAGCCTACAGCCATCCGCCCAAAAGTCTGTTCTGATGGCACTGAGTTTTCATTGTTCTGGATGTATAAGTCTGTGTGTCAGGTAC
AGCTGGGCCCAGCCAGCTTGAGTCACTCTTGTACAAGCTTGTTTTTTTCTGTCTTGTGAATGCACTTGATAATTTAAAAATAAAAATATC
TGTTTCTCTGCAGTTTCAGCTAATAATTTTGAGATATGTGTTGATTTTCTGATTGAATCACCAAGAATTTCAACAAGTTTAGAAATAATT
TAAGATGAATGAAAAATATGTCAGGGGGAGCTAAGCATTTGCTAAGCTCTTGATGTTTATATGAAAAATAAAGGGTTGTTTTTATATTGC
AACTACTAAAGAGAAAAATAGCAGTTGAAGCAAACACCAGGAAAATTTGGCTCTACTGAAAGCCCAGTCCTTTTCCCCTTTGTCTCGCTG
ACAAAGTAAGACTAGGGTTATGTTCATGAATAGATTAATAAAAGATGTTTCTTTACCACACAATCTGAGATGAGATGGGGTGGGGGAGAT
CATGACAGTGCCCTCCAAGCAATAGATCCAGCTGATAATCAAGCAGAAAATCAGACACCAGAATCCATTTGATGATGTACGGCATTAAAC

>75146_75146_1_RNGTT-AHI1_RNGTT_chr6_89479493_ENST00000265607_AHI1_chr6_135606785_ENST00000367800_length(amino acids)=475AA_BP=
MVREGSSAQPQDMAHNKIPPRWLNCPRRGQPVAGRFLPLKTMLGPRYDSQVAEENRFHPSMLSNYLKSLKVKMGLLVDLTNTSRFYDRND
IEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFNERNPPELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQARPPGIYKGD
YLKELFRRYGDIEEAPPPPLLPDWCFEDDEDEDEDEDGKKESEPGSSASFGKRRKERLKLGAIFLEGVTVKGVTQVTTQPKLGEVQQKCH
QFCGWEGSGFPGAQPVSMDKQNIKLLDLKPYKVSWKADGTRYMMLIDGTNEVFMIDRDNSVFHVSNLEFPFRKDLRMHLSNTLLDGEMII
DRVNGQAVPRYLIYDIIKFNSQPVGDCDFNVRLQCIEREIISPRHEKMKTGLIDKTQEPFSVRNKPFFDICTSRKKYKPGRCDDILKWKP

--------------------------------------------------------------
>75146_75146_2_RNGTT-AHI1_RNGTT_chr6_89479493_ENST00000369475_AHI1_chr6_135606785_ENST00000367800_length(transcript)=3707nt_BP=1591nt
CCCTGACGTTACCCGGATCGGAGAGGTTGGAATTCAGATTACGGCTGCGATTCGGGTGTCTCGGACCCCGGTGTGCACCGGACCACGGGG
AGGCGGCTCCAAAGGCGCGGTGAACGTTGGTGAGGGAGGGCAGCTCTGCGCAGCCCCAAGACATGGCTCACAACAAGATCCCGCCGCGGT
GGCTGAACTGTCCCCGGCGCGGCCAGCCGGTGGCAGGAAGATTCTTACCTCTGAAGACAATGTTAGGACCAAGATATGATAGTCAAGTTG
CTGAAGAAAATCGGTTCCATCCCAGCATGCTCTCAAATTACCTAAAGAGCCTAAAGGTTAAAATGGGCTTGTTGGTGGACCTGACAAATA
CTTCAAGGTTCTATGACCGAAATGACATAGAAAAAGAAGGAATCAAATATATAAAACTTCAGTGTAAAGGACATGGTGAGTGCCCTACCA
CTGAGAATACTGAGACCTTTATTCGTCTGTGTGAGCGGTTTAATGAAAGAAATCCACCTGAACTTATAGGTGTTCATTGTACTCATGGCT
TCAATCGCACTGGTTTCCTCATATGTGCCTTTTTGGTGGAGAAAATGGATTGGAGTATCGAAGCAGCAGTTGCTACTTTTGCCCAAGCCA
GACCACCAGGAATCTACAAGGGTGATTATTTGAAGGAACTTTTTCGTCGGTATGGTGACATAGAGGAAGCACCACCCCCACCTCTATTGC
CAGATTGGTGTTTTGAGGATGATGAAGACGAAGATGAGGATGAGGATGGAAAGAAGGAATCAGAACCCGGGTCAAGTGCTTCTTTTGGCA
AAAGGAGAAAAGAACGGTTAAAACTGGGCGCTATTTTCTTGGAAGGTGTTACTGTTAAAGGTGTAACTCAAGTAACAACACAACCAAAGT
TAGGAGAGGTACAGCAGAAGTGTCATCAATTCTGTGGCTGGGAAGGGTCTGGATTCCCTGGAGCACAGCCTGTTTCCATGGACAAGCAAA
ATATTAAACTTTTAGACCTGAAGCCATACAAAGTAAGCTGGAAAGCAGATGGTACTCGGTACATGATGTTGATTGATGGCACAAATGAAG
TTTTTATGATTGATAGAGACAATTCAGTATTTCATGTTTCAAATCTGGAATTTCCATTTCGTAAAGATCTTCGTATGCATTTATCAAATA
CTCTCTTGGATGGCGAGATGATTATTGACAGAGTAAATGGACAGGCTGTTCCTAGATATTTGATATATGACATAATTAAATTCAATTCAC
AGCCCGTTGGAGATTGTGATTTTAATGTTCGTCTGCAGTGTATAGAACGAGAAATTATAAGTCCTCGACACGAAAAAATGAAGACTGGGC
TCATTGACAAAACACAGGAACCATTTAGCGTCAGAAATAAGCCGTTTTTTGACATCTGTACTTCAAGAAAGCTACTTGAAGGAAATTTTG
CCAAAGAAGTGAGCCATGAAATGGATGGACTTATTTTTCAGCCTACTGGAAAATACAAACCTGGTCGATGTGATGATATTTTGAAATGGA
AGCCTCCCAGTCTGAATTCTGTGGATTTTCGTCTAAAAATAACAAGAATGGGAGGAGAAGGTAAAGAATTGAAGAAAAGTTAAGAGCTGC
CGAAATGCACAGAGGTGAAAATGACAAACCAAATGGAATTTCTCTTCAGAGTTCAGAATTTTCAGATACTAAGGAGGAAGAAAGGATCCA
CTACTTCTTGTTCTTATGAATGACTCTAGAAAAATCAGAATCAAGTTGTGGGTGGAAAAATCAACGTGGCCTTTGAGTTCAGTTGTTATA
AACCATTGTGACTATTGTTGGTCAAAGTATTGGTACTTATATTGTTAGTAATTGCATCATAATTACATTACCAGTGTTGGAAAACTAATG
AAGAAAACACTGTAATTGCTACTCAGCAAATGTGAATAAAAGGTGTTTGCGTTATTAGGATGTCTGTTAAGTAATCATTTAATATTATTA
TATTGGTAATGGTTGTATGTGTGATGCTATGCCCAGAATATGAAGTATCTGTTTTTGAAATTCACTTTATTTAAAAGATAAGCAGCTGAC
TGGGCACGGTGCCTCATGCCTGTAATCCTAGCACCTTGGGAGGCTGAGGCAGGTGGATCACCTAAGGTCAGGAGTTCAACAACACCAGCC
TGACCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATCAGCCGGGTCTCATGGCAGGCACCTGTAATCCCATCTACTGAGGCA
GGAGAATTGCTTGACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATCACGCCATTGCACTCCAGCCTGGGGGACAGAGCAAGACTCTATC
TCCAAAAAACAAAAAAGATAAGCAGCTTTAGAATATGGCGCATTCAAAACAGTCTCAGTAACAAAGACATTAAAAGAAAACAATTTACTT
TCTAATTAAAATTTTGTGTTTCTTAAGATCAAATCATATAGGTAACTTCATAGACCTAAATTAAAAGTGATTTTTGGCTGGACTGGCAAC
AATGTTCCCAATGTCTTTACTTTTTAAAAAAGGCTTTTCATATTTAAGCACATACCTATTTTGTAGACTTACATTGTTTAATATTTATTT
TAATCTTAATATTTTTACATTATTATATTGCATTATTTATTTTTTCTAAGTTCCAGAATAATAGTGTCATTATTATAGACTATATGTTTT
GAAGTTTGATATTATAATGGGATATTCATTTTTTGTTCTTTTCTTGACTCCTTTCTCAAGTGTGTGATAAGGTCTGCTGATAAAATATTT
AACCCCAAGAAAGTGAAAACTAATATAAAATTAGAAAGACCTATCCAAATTAGACAGTCAATTCCATTAAAATAAGAAGTGAGAAAAACA
ATGTTGGGCATTGAGGTGTAAATTTTGCCCAGATGTATACCCAGTGTGAAATATCTTCTAATAAAAATATATTTGGCTCTTATCCCTGCA
CATGTAGAGGCATAAAAATTGGTAAACATGTCCCGCTGTGTAGAACTTTAAAAAAAAGGCATTTTTGAAAGTGTTGAGTGGCACTGATAA
CTGGTGAAGCCTACAGCCATCCGCCCAAAAGTCTGTTCTGATGGCACTGAGTTTTCATTGTTCTGGATGTATAAGTCTGTGTGTCAGGTA
CAGCTGGGCCCAGCCAGCTTGAGTCACTCTTGTACAAGCTTGTTTTTTTCTGTCTTGTGAATGCACTTGATAATTTAAAAATAAAAATAT
CTGTTTCTCTGCAGTTTCAGCTAATAATTTTGAGATATGTGTTGATTTTCTGATTGAATCACCAAGAATTTCAACAAGTTTAGAAATAAT
TTAAGATGAATGAAAAATATGTCAGGGGGAGCTAAGCATTTGCTAAGCTCTTGATGTTTATATGAAAAATAAAGGGTTGTTTTTATATTG
CAACTACTAAAGAGAAAAATAGCAGTTGAAGCAAACACCAGGAAAATTTGGCTCTACTGAAAGCCCAGTCCTTTTCCCCTTTGTCTCGCT
GACAAAGTAAGACTAGGGTTATGTTCATGAATAGATTAATAAAAGATGTTTCTTTACCACACAATCTGAGATGAGATGGGGTGGGGGAGA
TCATGACAGTGCCCTCCAAGCAATAGATCCAGCTGATAATCAAGCAGAAAATCAGACACCAGAATCCATTTGATGATGTACGGCATTAAA

>75146_75146_2_RNGTT-AHI1_RNGTT_chr6_89479493_ENST00000369475_AHI1_chr6_135606785_ENST00000367800_length(amino acids)=498AA_BP=
MVREGSSAQPQDMAHNKIPPRWLNCPRRGQPVAGRFLPLKTMLGPRYDSQVAEENRFHPSMLSNYLKSLKVKMGLLVDLTNTSRFYDRND
IEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFNERNPPELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQARPPGIYKGD
YLKELFRRYGDIEEAPPPPLLPDWCFEDDEDEDEDEDGKKESEPGSSASFGKRRKERLKLGAIFLEGVTVKGVTQVTTQPKLGEVQQKCH
QFCGWEGSGFPGAQPVSMDKQNIKLLDLKPYKVSWKADGTRYMMLIDGTNEVFMIDRDNSVFHVSNLEFPFRKDLRMHLSNTLLDGEMII
DRVNGQAVPRYLIYDIIKFNSQPVGDCDFNVRLQCIEREIISPRHEKMKTGLIDKTQEPFSVRNKPFFDICTSRKLLEGNFAKEVSHEMD

--------------------------------------------------------------
>75146_75146_3_RNGTT-AHI1_RNGTT_chr6_89479493_ENST00000369485_AHI1_chr6_135606785_ENST00000367800_length(transcript)=3742nt_BP=1626nt
TGTGGAGTTGATCCTGAATGAAAGTGGCGCGCCGCCCCTGACGTTACCCGGATCGGAGAGGTTGGAATTCAGATTACGGCTGCGATTCGG
GTGTCTCGGACCCCGGTGTGCACCGGACCACGGGGAGGCGGCTCCAAAGGCGCGGTGAACGTTGGTGAGGGAGGGCAGCTCTGCGCAGCC
CCAAGACATGGCTCACAACAAGATCCCGCCGCGGTGGCTGAACTGTCCCCGGCGCGGCCAGCCGGTGGCAGGAAGATTCTTACCTCTGAA
GACAATGTTAGGACCAAGATATGATAGTCAAGTTGCTGAAGAAAATCGGTTCCATCCCAGCATGCTCTCAAATTACCTAAAGAGCCTAAA
GGTTAAAATGGGCTTGTTGGTGGACCTGACAAATACTTCAAGGTTCTATGACCGAAATGACATAGAAAAAGAAGGAATCAAATATATAAA
ACTTCAGTGTAAAGGACATGGTGAGTGCCCTACCACTGAGAATACTGAGACCTTTATTCGTCTGTGTGAGCGGTTTAATGAAAGAAATCC
ACCTGAACTTATAGGTGTTCATTGTACTCATGGCTTCAATCGCACTGGTTTCCTCATATGTGCCTTTTTGGTGGAGAAAATGGATTGGAG
TATCGAAGCAGCAGTTGCTACTTTTGCCCAAGCCAGACCACCAGGAATCTACAAGGGTGATTATTTGAAGGAACTTTTTCGTCGGTATGG
TGACATAGAGGAAGCACCACCCCCACCTCTATTGCCAGATTGGTGTTTTGAGGATGATGAAGACGAAGATGAGGATGAGGATGGAAAGAA
GGAATCAGAACCCGGGTCAAGTGCTTCTTTTGGCAAAAGGAGAAAAGAACGGTTAAAACTGGGCGCTATTTTCTTGGAAGGTGTTACTGT
TAAAGGTGTAACTCAAGTAACAACACAACCAAAGTTAGGAGAGGTACAGCAGAAGTGTCATCAATTCTGTGGCTGGGAAGGGTCTGGATT
CCCTGGAGCACAGCCTGTTTCCATGGACAAGCAAAATATTAAACTTTTAGACCTGAAGCCATACAAAGTAAGCTGGAAAGCAGATGGTAC
TCGGTACATGATGTTGATTGATGGCACAAATGAAGTTTTTATGATTGATAGAGACAATTCAGTATTTCATGTTTCAAATCTGGAATTTCC
ATTTCGTAAAGATCTTCGTATGCATTTATCAAATACTCTCTTGGATGGCGAGATGATTATTGACAGAGTAAATGGACAGGCTGTTCCTAG
ATATTTGATATATGACATAATTAAATTCAATTCACAGCCCGTTGGAGATTGTGATTTTAATGTTCGTCTGCAGTGTATAGAACGAGAAAT
TATAAGTCCTCGACACGAAAAAATGAAGACTGGGCTCATTGACAAAACACAGGAACCATTTAGCGTCAGAAATAAGCCGTTTTTTGACAT
CTGTACTTCAAGAAAGCTACTTGAAGGAAATTTTGCCAAAGAAGTGAGCCATGAAATGGATGGACTTATTTTTCAGCCTACTGGAAAATA
CAAACCTGGTCGATGTGATGATATTTTGAAATGGAAGCCTCCCAGTCTGAATTCTGTGGATTTTCGTCTAAAAATAACAAGAATGGGAGG
AGAAGGTAAAGAATTGAAGAAAAGTTAAGAGCTGCCGAAATGCACAGAGGTGAAAATGACAAACCAAATGGAATTTCTCTTCAGAGTTCA
GAATTTTCAGATACTAAGGAGGAAGAAAGGATCCACTACTTCTTGTTCTTATGAATGACTCTAGAAAAATCAGAATCAAGTTGTGGGTGG
AAAAATCAACGTGGCCTTTGAGTTCAGTTGTTATAAACCATTGTGACTATTGTTGGTCAAAGTATTGGTACTTATATTGTTAGTAATTGC
ATCATAATTACATTACCAGTGTTGGAAAACTAATGAAGAAAACACTGTAATTGCTACTCAGCAAATGTGAATAAAAGGTGTTTGCGTTAT
TAGGATGTCTGTTAAGTAATCATTTAATATTATTATATTGGTAATGGTTGTATGTGTGATGCTATGCCCAGAATATGAAGTATCTGTTTT
TGAAATTCACTTTATTTAAAAGATAAGCAGCTGACTGGGCACGGTGCCTCATGCCTGTAATCCTAGCACCTTGGGAGGCTGAGGCAGGTG
GATCACCTAAGGTCAGGAGTTCAACAACACCAGCCTGACCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATCAGCCGGGTCT
CATGGCAGGCACCTGTAATCCCATCTACTGAGGCAGGAGAATTGCTTGACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATCACGCCATT
GCACTCCAGCCTGGGGGACAGAGCAAGACTCTATCTCCAAAAAACAAAAAAGATAAGCAGCTTTAGAATATGGCGCATTCAAAACAGTCT
CAGTAACAAAGACATTAAAAGAAAACAATTTACTTTCTAATTAAAATTTTGTGTTTCTTAAGATCAAATCATATAGGTAACTTCATAGAC
CTAAATTAAAAGTGATTTTTGGCTGGACTGGCAACAATGTTCCCAATGTCTTTACTTTTTAAAAAAGGCTTTTCATATTTAAGCACATAC
CTATTTTGTAGACTTACATTGTTTAATATTTATTTTAATCTTAATATTTTTACATTATTATATTGCATTATTTATTTTTTCTAAGTTCCA
GAATAATAGTGTCATTATTATAGACTATATGTTTTGAAGTTTGATATTATAATGGGATATTCATTTTTTGTTCTTTTCTTGACTCCTTTC
TCAAGTGTGTGATAAGGTCTGCTGATAAAATATTTAACCCCAAGAAAGTGAAAACTAATATAAAATTAGAAAGACCTATCCAAATTAGAC
AGTCAATTCCATTAAAATAAGAAGTGAGAAAAACAATGTTGGGCATTGAGGTGTAAATTTTGCCCAGATGTATACCCAGTGTGAAATATC
TTCTAATAAAAATATATTTGGCTCTTATCCCTGCACATGTAGAGGCATAAAAATTGGTAAACATGTCCCGCTGTGTAGAACTTTAAAAAA
AAGGCATTTTTGAAAGTGTTGAGTGGCACTGATAACTGGTGAAGCCTACAGCCATCCGCCCAAAAGTCTGTTCTGATGGCACTGAGTTTT
CATTGTTCTGGATGTATAAGTCTGTGTGTCAGGTACAGCTGGGCCCAGCCAGCTTGAGTCACTCTTGTACAAGCTTGTTTTTTTCTGTCT
TGTGAATGCACTTGATAATTTAAAAATAAAAATATCTGTTTCTCTGCAGTTTCAGCTAATAATTTTGAGATATGTGTTGATTTTCTGATT
GAATCACCAAGAATTTCAACAAGTTTAGAAATAATTTAAGATGAATGAAAAATATGTCAGGGGGAGCTAAGCATTTGCTAAGCTCTTGAT
GTTTATATGAAAAATAAAGGGTTGTTTTTATATTGCAACTACTAAAGAGAAAAATAGCAGTTGAAGCAAACACCAGGAAAATTTGGCTCT
ACTGAAAGCCCAGTCCTTTTCCCCTTTGTCTCGCTGACAAAGTAAGACTAGGGTTATGTTCATGAATAGATTAATAAAAGATGTTTCTTT
ACCACACAATCTGAGATGAGATGGGGTGGGGGAGATCATGACAGTGCCCTCCAAGCAATAGATCCAGCTGATAATCAAGCAGAAAATCAG

>75146_75146_3_RNGTT-AHI1_RNGTT_chr6_89479493_ENST00000369485_AHI1_chr6_135606785_ENST00000367800_length(amino acids)=498AA_BP=
MVREGSSAQPQDMAHNKIPPRWLNCPRRGQPVAGRFLPLKTMLGPRYDSQVAEENRFHPSMLSNYLKSLKVKMGLLVDLTNTSRFYDRND
IEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFNERNPPELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQARPPGIYKGD
YLKELFRRYGDIEEAPPPPLLPDWCFEDDEDEDEDEDGKKESEPGSSASFGKRRKERLKLGAIFLEGVTVKGVTQVTTQPKLGEVQQKCH
QFCGWEGSGFPGAQPVSMDKQNIKLLDLKPYKVSWKADGTRYMMLIDGTNEVFMIDRDNSVFHVSNLEFPFRKDLRMHLSNTLLDGEMII
DRVNGQAVPRYLIYDIIKFNSQPVGDCDFNVRLQCIEREIISPRHEKMKTGLIDKTQEPFSVRNKPFFDICTSRKLLEGNFAKEVSHEMD

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for RNGTT-AHI1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	RNGTT	chr6:89479493	chr6:135606785	ENST00000265607	-	12	15	330_386	456.6666666666667	575.0	POLR2A
Hgene	RNGTT	chr6:89479493	chr6:135606785	ENST00000369485	-	13	16	330_386	479.6666666666667	598.0	POLR2A
Tgene	AHI1	chr6:89479493	chr6:135606785	ENST00000327035		0	23	141_434	0	1054.0	HAP1

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	AHI1	chr6:89479493	chr6:135606785	ENST00000367800		25	27	141_434	1196.0	1197.0	HAP1
Tgene	AHI1	chr6:89479493	chr6:135606785	ENST00000457866		26	28	141_434	1196.0	1197.0	HAP1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for RNGTT-AHI1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for RNGTT-AHI1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source