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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ROBO1-MED12L (FusionGDB2 ID:75258)

Fusion Gene Summary for ROBO1-MED12L

check button Fusion gene summary
Fusion gene informationFusion gene name: ROBO1-MED12L
Fusion gene ID: 75258
HgeneTgene
Gene symbol

ROBO1

MED12L

Gene ID

6091

116931

Gene nameroundabout guidance receptor 1mediator complex subunit 12L
SynonymsDUTT1|SAX3NOPAR|TNRC11L|TRALP|TRALPUSH
Cytomap

3p12.3

3q25.1

Type of geneprotein-codingprotein-coding
Descriptionroundabout homolog 1deleted in U twenty twentyroundabout, axon guidance receptor, homolog 1mediator of RNA polymerase II transcription subunit 12-like proteinmediator complex subunit 12 likemediator of RNA polymerase II transcription, subunit 12 homolog-likeno opposite paired repeat proteinthyroid hormone receptor-associated-like proteintr
Modification date2020031320200313
UniProtAcc.

Q86YW9

Ensembl transtripts involved in fusion geneENST00000436010, ENST00000464233, 
ENST00000467549, ENST00000495273, 
ENST00000466906, 		ENST00000309237, 
ENST00000422248, ENST00000491549, 
ENST00000273432, ENST00000474524, 
Fusion gene scores* DoF score18 X 16 X 7=20162 X 2 X 2=8
# samples 182
** MAII scorelog2(18/2016*10)=-3.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: ROBO1 [Title/Abstract] AND MED12L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointROBO1(78987751)-MED12L(150911277), # samples:2
Anticipated loss of major functional domain due to fusion event.ROBO1-MED12L seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
ROBO1-MED12L seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneROBO1

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

12504588

HgeneROBO1

GO:0021836

chemorepulsion involved in postnatal olfactory bulb interneuron migration

15207848

HgeneROBO1

GO:0050772

positive regulation of axonogenesis

12504588

HgeneROBO1

GO:0050925

negative regulation of negative chemotaxis

11748139


check buttonFusion gene breakpoints across ROBO1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MED12L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-66-2781-01AROBO1chr3

78987751

-MED12Lchr3

150911277

+


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Fusion Gene ORF analysis for ROBO1-MED12L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000436010ENST00000309237ROBO1chr3

78987751

-MED12Lchr3

150911277

+
5CDS-intronENST00000436010ENST00000422248ROBO1chr3

78987751

-MED12Lchr3

150911277

+
5CDS-intronENST00000436010ENST00000491549ROBO1chr3

78987751

-MED12Lchr3

150911277

+
5CDS-intronENST00000464233ENST00000309237ROBO1chr3

78987751

-MED12Lchr3

150911277

+
5CDS-intronENST00000464233ENST00000422248ROBO1chr3

78987751

-MED12Lchr3

150911277

+
5CDS-intronENST00000464233ENST00000491549ROBO1chr3

78987751

-MED12Lchr3

150911277

+
5CDS-intronENST00000467549ENST00000309237ROBO1chr3

78987751

-MED12Lchr3

150911277

+
5CDS-intronENST00000467549ENST00000422248ROBO1chr3

78987751

-MED12Lchr3

150911277

+
5CDS-intronENST00000467549ENST00000491549ROBO1chr3

78987751

-MED12Lchr3

150911277

+
5CDS-intronENST00000495273ENST00000309237ROBO1chr3

78987751

-MED12Lchr3

150911277

+
5CDS-intronENST00000495273ENST00000422248ROBO1chr3

78987751

-MED12Lchr3

150911277

+
5CDS-intronENST00000495273ENST00000491549ROBO1chr3

78987751

-MED12Lchr3

150911277

+
Frame-shiftENST00000436010ENST00000273432ROBO1chr3

78987751

-MED12Lchr3

150911277

+
Frame-shiftENST00000436010ENST00000474524ROBO1chr3

78987751

-MED12Lchr3

150911277

+
Frame-shiftENST00000467549ENST00000273432ROBO1chr3

78987751

-MED12Lchr3

150911277

+
Frame-shiftENST00000467549ENST00000474524ROBO1chr3

78987751

-MED12Lchr3

150911277

+
Frame-shiftENST00000495273ENST00000273432ROBO1chr3

78987751

-MED12Lchr3

150911277

+
Frame-shiftENST00000495273ENST00000474524ROBO1chr3

78987751

-MED12Lchr3

150911277

+
In-frameENST00000464233ENST00000273432ROBO1chr3

78987751

-MED12Lchr3

150911277

+
In-frameENST00000464233ENST00000474524ROBO1chr3

78987751

-MED12Lchr3

150911277

+
intron-3CDSENST00000466906ENST00000273432ROBO1chr3

78987751

-MED12Lchr3

150911277

+
intron-3CDSENST00000466906ENST00000474524ROBO1chr3

78987751

-MED12Lchr3

150911277

+
intron-intronENST00000466906ENST00000309237ROBO1chr3

78987751

-MED12Lchr3

150911277

+
intron-intronENST00000466906ENST00000422248ROBO1chr3

78987751

-MED12Lchr3

150911277

+
intron-intronENST00000466906ENST00000491549ROBO1chr3

78987751

-MED12Lchr3

150911277

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000464233ROBO1chr378987751-ENST00000474524MED12Lchr3150911277+935161362550821485
ENST00000464233ROBO1chr378987751-ENST00000273432MED12Lchr3150911277+543361362544941289

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000464233ENST00000474524ROBO1chr378987751-MED12Lchr3150911277+0.0006174920.9993825
ENST00000464233ENST00000273432ROBO1chr378987751-MED12Lchr3150911277+0.0023790750.9976209

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Fusion Genomic Features for ROBO1-MED12L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ROBO1chr378987750-MED12Lchr3150911276+1.88E-050.99998116
ROBO1chr378987750-MED12Lchr3150911276+1.88E-050.99998116

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ROBO1-MED12L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:78987751/chr3:150911277)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MED12L

Q86YW9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneROBO1chr3:78987751chr3:150911277ENST00000464233-43168_1641661652.0DomainNote=Ig-like C2-type 1
TgeneMED12Lchr3:78987751chr3:150911277ENST0000030923713151877_2134691757.0Compositional biasNote=Gln-rich
TgeneMED12Lchr3:78987751chr3:150911277ENST0000042224812141877_2134656722.0Compositional biasNote=Gln-rich
TgeneMED12Lchr3:78987751chr3:150911277ENST0000047452412431877_21346562146.0Compositional biasNote=Gln-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneROBO1chr3:78987751chr3:150911277ENST00000436010-229170_2571271613.0DomainNote=Ig-like C2-type 2
HgeneROBO1chr3:78987751chr3:150911277ENST00000436010-229262_3461271613.0DomainNote=Ig-like C2-type 3
HgeneROBO1chr3:78987751chr3:150911277ENST00000436010-229351_4461271613.0DomainNote=Ig-like C2-type 4
HgeneROBO1chr3:78987751chr3:150911277ENST00000436010-229455_5411271613.0DomainNote=Ig-like C2-type 5
HgeneROBO1chr3:78987751chr3:150911277ENST00000436010-229563_6571271613.0DomainFibronectin type-III 1
HgeneROBO1chr3:78987751chr3:150911277ENST00000436010-229676_7731271613.0DomainFibronectin type-III 2
HgeneROBO1chr3:78987751chr3:150911277ENST00000436010-22968_1641271613.0DomainNote=Ig-like C2-type 1
HgeneROBO1chr3:78987751chr3:150911277ENST00000436010-229778_8741271613.0DomainFibronectin type-III 3
HgeneROBO1chr3:78987751chr3:150911277ENST00000464233-431170_2571661652.0DomainNote=Ig-like C2-type 2
HgeneROBO1chr3:78987751chr3:150911277ENST00000464233-431262_3461661652.0DomainNote=Ig-like C2-type 3
HgeneROBO1chr3:78987751chr3:150911277ENST00000464233-431351_4461661652.0DomainNote=Ig-like C2-type 4
HgeneROBO1chr3:78987751chr3:150911277ENST00000464233-431455_5411661652.0DomainNote=Ig-like C2-type 5
HgeneROBO1chr3:78987751chr3:150911277ENST00000464233-431563_6571661652.0DomainFibronectin type-III 1
HgeneROBO1chr3:78987751chr3:150911277ENST00000464233-431676_7731661652.0DomainFibronectin type-III 2
HgeneROBO1chr3:78987751chr3:150911277ENST00000464233-431778_8741661652.0DomainFibronectin type-III 3
HgeneROBO1chr3:78987751chr3:150911277ENST00000467549-229170_2571271552.0DomainNote=Ig-like C2-type 2
HgeneROBO1chr3:78987751chr3:150911277ENST00000467549-229262_3461271552.0DomainNote=Ig-like C2-type 3
HgeneROBO1chr3:78987751chr3:150911277ENST00000467549-229351_4461271552.0DomainNote=Ig-like C2-type 4
HgeneROBO1chr3:78987751chr3:150911277ENST00000467549-229455_5411271552.0DomainNote=Ig-like C2-type 5
HgeneROBO1chr3:78987751chr3:150911277ENST00000467549-229563_6571271552.0DomainFibronectin type-III 1
HgeneROBO1chr3:78987751chr3:150911277ENST00000467549-229676_7731271552.0DomainFibronectin type-III 2
HgeneROBO1chr3:78987751chr3:150911277ENST00000467549-22968_1641271552.0DomainNote=Ig-like C2-type 1
HgeneROBO1chr3:78987751chr3:150911277ENST00000467549-229778_8741271552.0DomainFibronectin type-III 3
HgeneROBO1chr3:78987751chr3:150911277ENST00000495273-229170_2571271607.0DomainNote=Ig-like C2-type 2
HgeneROBO1chr3:78987751chr3:150911277ENST00000495273-229262_3461271607.0DomainNote=Ig-like C2-type 3
HgeneROBO1chr3:78987751chr3:150911277ENST00000495273-229351_4461271607.0DomainNote=Ig-like C2-type 4
HgeneROBO1chr3:78987751chr3:150911277ENST00000495273-229455_5411271607.0DomainNote=Ig-like C2-type 5
HgeneROBO1chr3:78987751chr3:150911277ENST00000495273-229563_6571271607.0DomainFibronectin type-III 1
HgeneROBO1chr3:78987751chr3:150911277ENST00000495273-229676_7731271607.0DomainFibronectin type-III 2
HgeneROBO1chr3:78987751chr3:150911277ENST00000495273-22968_1641271607.0DomainNote=Ig-like C2-type 1
HgeneROBO1chr3:78987751chr3:150911277ENST00000495273-229778_8741271607.0DomainFibronectin type-III 3
HgeneROBO1chr3:78987751chr3:150911277ENST00000436010-22926_8971271613.0Topological domainExtracellular
HgeneROBO1chr3:78987751chr3:150911277ENST00000436010-229919_16511271613.0Topological domainCytoplasmic
HgeneROBO1chr3:78987751chr3:150911277ENST00000464233-43126_8971661652.0Topological domainExtracellular
HgeneROBO1chr3:78987751chr3:150911277ENST00000464233-431919_16511661652.0Topological domainCytoplasmic
HgeneROBO1chr3:78987751chr3:150911277ENST00000467549-22926_8971271552.0Topological domainExtracellular
HgeneROBO1chr3:78987751chr3:150911277ENST00000467549-229919_16511271552.0Topological domainCytoplasmic
HgeneROBO1chr3:78987751chr3:150911277ENST00000495273-22926_8971271607.0Topological domainExtracellular
HgeneROBO1chr3:78987751chr3:150911277ENST00000495273-229919_16511271607.0Topological domainCytoplasmic
HgeneROBO1chr3:78987751chr3:150911277ENST00000436010-229898_9181271613.0TransmembraneHelical
HgeneROBO1chr3:78987751chr3:150911277ENST00000464233-431898_9181661652.0TransmembraneHelical
HgeneROBO1chr3:78987751chr3:150911277ENST00000467549-229898_9181271552.0TransmembraneHelical
HgeneROBO1chr3:78987751chr3:150911277ENST00000495273-229898_9181271607.0TransmembraneHelical


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Fusion Gene Sequence for ROBO1-MED12L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>75258_75258_1_ROBO1-MED12L_ROBO1_chr3_78987751_ENST00000464233_MED12L_chr3_150911277_ENST00000273432_length(transcript)=5433nt_BP=613nt
AAAGTTGCAGGGCTGCGTCTGCACTACGGAGCCTCTAGATTGCTGAAAACAGTCTTATGGAAGGATAACACATTGTCTGTCACTGGCTGG
TTGTAATGCAAGGAAGGGACAAAGATGAAATGGAAACATGTTCCTTTTTTGGTCATGATATCACTCCTCAGCTTATCCCCAAATCACCTG
TTTCTGGCCCAGCTTATTCCAGACCCTGAAGATGTAGAGAGGGGGAACGACCACGGGACGCCAATCCCCACCTCTGATAACGATGACAAT
TCGCTGGGCTATACAGGCTCCCGTCTTCGTCAGGAAGATTTTCCACCTCGCATTGTTGAACACCCTTCAGACCTGATTGTCTCAAAAGGA
GAACCTGCAACTTTGAACTGCAAAGCTGAAGGCCGCCCCACACCCACTATTGAATGGTACAAAGGGGGAGAGAGAGTGGAGACAGACAAA
GATGACCCTCGCTCACACCGAATGTTGCTGCCGAGTGGATCTTTATTTTTCTTACGTATAGTACATGGACGGAAAAGTAGACCTGATGAA
GGAGTCTATGTCTGTGTAGCAAGGAATTACCTTGGAGAGGCTGTGAGCCACAATGCATCGCTGGAAGTAGCCAATTTTTTCTCCTATGCC
TGGAGAATCCTGTGAGAATGCCAACACTTCGTTGGGCAGAAGAATGTCAGTTAATTGTGAGAAGTTGGTGAAGAGGGAAAAGCCAAGGGA
ATTAATTTTTCCATCTAATTATGACCTCCTTCGCCACTTACAGTATGCAACACATTTTCCTATACCTCTGGATGAATCTTCAAGTCATGA
ATGTAACCAGCGCACAATCCTTCTCTATGGAGTCGGCAAAGAGCGTGATGAAGCAAGGCATCAGCTGAAGAAGATTACCAAAGATATCCT
GAAAATTCTAAATAAGAAGAGCACCACAGAGACAGGGGTTGGGGACGAAGGACAAAAAGCCAGGAAGAACAAACAGGAGACATTTCCAAC
ACTGGAGACTGTGTTCACTAAACTCCAGCTCCTTTCATATTTTGATCAACATCAAGTGACATCTCAGATTTCTAACAATGTGCTAGAACA
AATCACAAGCTTTGCGTCAGGAACATCCTATCATCTCCCTTTGGCTCACCACATTCAGCTCATCTTTGATCTCATGGAGCCAGCACTGAA
CATCAACGGACTAATTGACTTCGCAATACAGTTACTAAATGAACTGAGTGTTGTGGAAGCTGAACTGCTCCTAAAATCCTCCAGCCTGGC
AGGAAGTTATACAACAGGACTGTGTGTCTGCATCGTGGCTGTTCTCAGGCGCTATCACAGTTGTCTAATCTTGAATCCTGATCAGACAGC
CCAGGTGTTTGAAGGGTTGTGTGGTGTGGTCAAGCATGTCGTAAACCCCTCAGAATGTTCTTCCCCTGAAAGATGCATTTTAGCCTACCT
CTATGATCTCTATGTGTCATGTAGCCACCTCAGAAGTAAATTTGGAGACCTCTTCAGTAGTGCCTGTTCAAAAGTAAAGCAAACCATATA
TAATAACGTGATGCCTGCAAATTCGAACTTGCGATGGGATCCAGACTTCATGATGGATTTTATTGAGAATCCCTCAGCCCGCAGCATCAA
CTACTCAATGCTGGGCAAGATCCTCAGTGACAATGCGGCCAATCGCTACAGCTTTGTCTGCAATACACTCATGAATGTATGTATGGGCCA
TCAGGATGCTGGCAGGATTAACGACATAGCCAATTTCTCCTCTGAGCTTACGGCTTGCTGCACTGTTCTTAGTTCAGAATGGCTGGGGGT
TCTGAAGGCTCTTTGTTGTTCTTCAAATCACGTGTGGGGGTTTAATGATGTACTTTGCACTGTAGATGTGAGTGACCTTTCATTCCATGA
TTCATTAGCTACTTTCATTGCTATTCTGATAGCACGACAGTGTTTTTCCCTGGAGGACGTCGTGCAGCATGTCGCACTTCCCTCTCTTCT
AGCAGCAGCTTGTGGGGATGCGGACGCCGAGCCTGGGGCGAGAATGACATGCCGACTCTTGCTTCATCTCTTCCGAGCTCCCCAGGCCTG
CTTCTTACCTCAAGCAACGGGCAAACCTTTCCCTGGAATAAGATCATCTTGTGATAGACACCTCTTAGCCGCTGCTCACAACAGCATTGA
AGTGGGAGCCGTGTTTGCTGTCTTAAAAGCAATTATGATGCTTGGAGATGCCAAAATTGGCAATAACAGTGTCAGCTCTTTAAAGAATGA
TGACTTCACCATGAGAGGTTTGCGATGTGATGGGAATGCTGATGATATCTGGACTGCCTCACAAAATCCAAAATCCTGTGGGAAAAGCAT
TTCCATAGAAACTGCCAATTTAAGAGAATACGCTAGATATGTACTGAGGACTATCTGTCAACAGGAATGGGTAGGAGAGCATTGCTTAAA
AGAACCTGAAAGATTATGTACAGACAAAGAACTTATATTGGACCCTGTGCTTTCAAATATGCAAGCACAGAAATTACTGCAGCTTATCTG
TTATCCTCATGGCATTAAAGAATGTACCGAGGGGGACAATCTGCAAAGACAGCACATTAAGCGTATTCTTCAGAATCTTGAGCAGTGGAC
ACTGAGGCAATCCTGGTTAGAACTCCAGCTAATGATCAAACAGTGCTTGAAGGACCCTGGCTCTGGTTCTGTGGCCGAAATGAACAACTT
ACTGGACAATATTGCAAAGGCAACAATAGAGGTATTCCAGCAGTCTGCAGACCTAAATAATTCTTCTAATTCTGGCATGAGCCTCTTCAA
CCCAAACAGTATTGGAAGTGCTGATACAAGTAGCACGAGACAGAATGGAATAAAGACATTCCTAAGTTCCTCCGAACGCAGGGGTGTATG
GTTGGTGGCCCCCCTCATCGCCAGGTTGCCAACTTCTGTGCAAGGAAGAGTGCTGAAAGCCGCTGGGGAAGAGCTGGAGAAGGGACAGCA
CTTGGGTTCTTCTTCCAAAAAGGAAAGGGACAGACAGAAACAGAAAAGTATGTCTCTTTTGAGTCAACAACCCTTCCTCTCACTGGTACT
TACCTGCCTTAAGGGACAAGATGAACAAAGGGAAGGCCTCCTAACATCTCTCCAGAATCAAGTTAACCAGATTTTAAGTAACTGGAGAGA
AGAACGATACCAAGATGACATAAAAGCGCGGCAGATGATGCACGAAGCATTGCAACTCCGCCTAAATTTGGTAGGAGGAATGTTTGACAC
GGTGCAGAGGAGCACCCAGTGGACTACAGACTGGGCCCTGCTACTCCTTCAGATCATTACTTCAGGAACTGTTGACATGCACACTAACAA
TGAATTATTCACAACAGTTCTTGACATGCTGGGTGTTTTAATCAATGGAACGTTAGCCTCTGACCTATCAAATGCATCCCCTGGGGGATC
TGAAGAGAACAAGCGTGCATACATGAATTTAGTAAAGAAACTGAAAAAAGAGCTAGGAGACAAGCGATCAGAAAGTATTGACAAAGTTCG
ACAGTTACTACCTTTGCCGAAACAGACATGTGATGTCATCACTTGTGAACCTATGGGTTCCTTGATTGACACAAAAGGAAACAAAATTGC
TGGATTTGACTCTATAGATAAAAAACAGGGTCTCCAGGTCTCTACGAAGCAGAAGGTGTCCCCGTGGGACTTGTTTGAGGGTCAGAAGAA
CCCAGCTCCTTTGTCCTGGGCCTGGTTTGGGACAGTCCGAGTGGACCGAAGAGTGATCAAGTACGAGGAGCAGCATCACCTCCTGCTGTA
TCACACACACCCCATGCCCAAGCCCCGCAGTTACTACCTCCAGCCACTGCCCCTGCCTCCTGAGGAGGAAGAGGAAGAGCCCACATCTCC
AGTTTCTCAGGAACCAGAAAGGAAGTCCGCTGAGCTGTCAGATCAGGGAAAAACCACAACAGATGAAGAAAAGAAAACAAAAGGAAGGAA
GCGCAAGACGAAATCTAGCTCAAGAGTTGATGAATATCCACAGAGCAACATATACCGAGTGCCTCCTAATTACTCGCCTATCTCCTCCCA
AATGATGCACCATCCACAGTCCACCTTGTGGGGTTACAACCTCGTGGGCCAGCCCCAGCAGCCCGGCTTTTTCCTTCAGAACCAATCTCT
TACTCCAGGTGGCTCCAGATTGGACCCTGCAGGCTCCTTTGTCCCAACCAACACCAAACAAGCTCTGTCAAACATGCTACAGCGGCGCTC
AGGCGCCATGATGCAGCCGCCTTCTCTTCATGCAATCACATCGCAGCAGCAGTTGATACAGATGAAGCTTCTGCAGCAGCAGCAGCAACA
GCGACTTCTCAGGCAAGCCCAGACTCGGCCTTTCCAACAGTTTCCCAGGCAAGGCTTGCAGCAGACCCAGCAGCAGCAGCAGACGGCCGC
CTTGGTGCGGCAGCTCCAGAAGCAGCTTTCCAGCAACCAGCCACAGCAAGGAGTGACTCCGTATGGGCATCCTTCACACTTCTGAATCTG
CAAGAGGAGAAGACATGACGTTTTATGTTTGCACTGAAAAACAGAAAATCAAATTTAATGCATTAGTCATCTTAAAAATGTCCCTTTTTT
TCATTTCTTTGACATTTTACTATATTTTATGCTACATCTCACAAAAAAAAAAAAAGGTGTTTAAACAAAAAGCCAAGGAGAAGTTGTGGT
TTGATTTTGTTGAATTCACCTTTAAAGTAGGTTTACAAATGTGAATCATGCAGGCAGGCCTACTCCCGGAAGAGTGTGCTAGCAGACCTT
TTGAAATTGGTGCTTTTTTTGAATCTCACATTTCTAGAAAGAATGGATTATGATGGATCTAAGGTATTTATGTATTTCATTCATTAATGA
TGACGTTGTTTTTTTTTTTTTAATTTTATTTTCCAAACTGTGCTGGACCAAACTACTGATTTGAAAGGCATGTCAGATCTTGACAGAAAC
ATGGCCTGTTTATTCTGCATTCACCTGTGATGGTGAAACGGACATTTATTTGCATCGCTCTAATTTGAAATGTTTGTAATCTCATAAGCA
CTTTATAAACTTTGTTCTTATTTATGTAGGACTCTTCTTTGCTTTTGTTGTGGTCAAAAGGTGCTGAAACAGATTGTTGCTTCGTACTTA
AACTTCTTAAACCAAGAACCTAAACCAAGGTTTCTTTGAGAGCCGCCCTAAGATGTGCGGAAACCTGTTAGAAGTAGCTGTACTCAAATT
TGTTTTGAGGCAAGATCATTGATGAGAGTCATTGTGAAGGTACAACATGTAAATCCTAAAGGCCTGAAAGAACTGCAGTGGAATCGTCCA
ACTATTTATTGCCAGTTTTGGTTCTCCTGAACCTTATGCCACCTTAAGGGGAAAAAAAAATCCAGTAGCTGGCTTGAGATTCCAGTGCTC

>75258_75258_1_ROBO1-MED12L_ROBO1_chr3_78987751_ENST00000464233_MED12L_chr3_150911277_ENST00000273432_length(amino acids)=1289AA_BP=
MPGESCENANTSLGRRMSVNCEKLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKD
ILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPA
LNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILA
YLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCM
GHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPS
LLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLK
NDDFTMRGLRCDGNADDIWTASQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQL
ICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSL
FNPNSIGSADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSL
VLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHT
NNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNK
IAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPT
SPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGFFLQNQ
SLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQFPRQGLQQTQQQQQT

--------------------------------------------------------------
>75258_75258_2_ROBO1-MED12L_ROBO1_chr3_78987751_ENST00000464233_MED12L_chr3_150911277_ENST00000474524_length(transcript)=9351nt_BP=613nt
AAAGTTGCAGGGCTGCGTCTGCACTACGGAGCCTCTAGATTGCTGAAAACAGTCTTATGGAAGGATAACACATTGTCTGTCACTGGCTGG
TTGTAATGCAAGGAAGGGACAAAGATGAAATGGAAACATGTTCCTTTTTTGGTCATGATATCACTCCTCAGCTTATCCCCAAATCACCTG
TTTCTGGCCCAGCTTATTCCAGACCCTGAAGATGTAGAGAGGGGGAACGACCACGGGACGCCAATCCCCACCTCTGATAACGATGACAAT
TCGCTGGGCTATACAGGCTCCCGTCTTCGTCAGGAAGATTTTCCACCTCGCATTGTTGAACACCCTTCAGACCTGATTGTCTCAAAAGGA
GAACCTGCAACTTTGAACTGCAAAGCTGAAGGCCGCCCCACACCCACTATTGAATGGTACAAAGGGGGAGAGAGAGTGGAGACAGACAAA
GATGACCCTCGCTCACACCGAATGTTGCTGCCGAGTGGATCTTTATTTTTCTTACGTATAGTACATGGACGGAAAAGTAGACCTGATGAA
GGAGTCTATGTCTGTGTAGCAAGGAATTACCTTGGAGAGGCTGTGAGCCACAATGCATCGCTGGAAGTAGCCAATTTTTTCTCCTATGCC
TGGAGAATCCTGTGAGAATGCCAACACTTCGTTGGGCAGAAGAATGTCAGTTAATTGTGAGAAGTTGGTGAAGAGGGAAAAGCCAAGGGA
ATTAATTTTTCCATCTAATTATGACCTCCTTCGCCACTTACAGTATGCAACACATTTTCCTATACCTCTGGATGAATCTTCAAGTCATGA
ATGTAACCAGCGCACAATCCTTCTCTATGGAGTCGGCAAAGAGCGTGATGAAGCAAGGCATCAGCTGAAGAAGATTACCAAAGATATCCT
GAAAATTCTAAATAAGAAGAGCACCACAGAGACAGGGGTTGGGGACGAAGGACAAAAAGCCAGGAAGAACAAACAGGAGACATTTCCAAC
ACTGGAGACTGTGTTCACTAAACTCCAGCTCCTTTCATATTTTGATCAACATCAAGTGACATCTCAGATTTCTAACAATGTGCTAGAACA
AATCACAAGCTTTGCGTCAGGAACATCCTATCATCTCCCTTTGGCTCACCACATTCAGCTCATCTTTGATCTCATGGAGCCAGCACTGAA
CATCAACGGACTAATTGACTTCGCAATACAGTTACTAAATGAACTGAGTGTTGTGGAAGCTGAACTGCTCCTAAAATCCTCCAGCCTGGC
AGGAAGTTATACAACAGGACTGTGTGTCTGCATCGTGGCTGTTCTCAGGCGCTATCACAGTTGTCTAATCTTGAATCCTGATCAGACAGC
CCAGGTGTTTGAAGGGTTGTGTGGTGTGGTCAAGCATGTCGTAAACCCCTCAGAATGTTCTTCCCCTGAAAGATGCATTTTAGCCTACCT
CTATGATCTCTATGTGTCATGTAGCCACCTCAGAAGTAAATTTGGAGACCTCTTCAGTAGTGCCTGTTCAAAAGTAAAGCAAACCATATA
TAATAACGTGATGCCTGCAAATTCGAACTTGCGATGGGATCCAGACTTCATGATGGATTTTATTGAGAATCCCTCAGCCCGCAGCATCAA
CTACTCAATGCTGGGCAAGATCCTCAGTGACAATGCGGCCAATCGCTACAGCTTTGTCTGCAATACACTCATGAATGTATGTATGGGCCA
TCAGGATGCTGGCAGGATTAACGACATAGCCAATTTCTCCTCTGAGCTTACGGCTTGCTGCACTGTTCTTAGTTCAGAATGGCTGGGGGT
TCTGAAGGCTCTTTGTTGTTCTTCAAATCACGTGTGGGGGTTTAATGATGTACTTTGCACTGTAGATGTGAGTGACCTTTCATTCCATGA
TTCATTAGCTACTTTCATTGCTATTCTGATAGCACGACAGTGTTTTTCCCTGGAGGACGTCGTGCAGCATGTCGCACTTCCCTCTCTTCT
AGCAGCAGCTTGTGGGGATGCGGACGCCGAGCCTGGGGCGAGAATGACATGCCGACTCTTGCTTCATCTCTTCCGAGCTCCCCAGGCCTG
CTTCTTACCTCAAGCAACGGGCAAACCTTTCCCTGGAATAAGATCATCTTGTGATAGACACCTCTTAGCCGCTGCTCACAACAGCATTGA
AGTGGGAGCCGTGTTTGCTGTCTTAAAAGCAATTATGATGCTTGGAGATGCCAAAATTGGCAATAACAGTGTCAGCTCTTTAAAGAATGA
TGACTTCACCATGAGAGGTTTGCGATGTGATGGGAATGCTGATGATATCTGGACTGCCTCACAAAATCCAAAATCCTGTGGGAAAAGCAT
TTCCATAGAAACTGCCAATTTAAGAGAATACGCTAGATATGTACTGAGGACTATCTGTCAACAGGAATGGGTAGGAGAGCATTGCTTAAA
AGAACCTGAAAGATTATGTACAGACAAAGAACTTATATTGGACCCTGTGCTTTCAAATATGCAAGCACAGAAATTACTGCAGCTTATCTG
TTATCCTCATGGCATTAAAGAATGTACCGAGGGGGACAATCTGCAAAGACAGCACATTAAGCGTATTCTTCAGAATCTTGAGCAGTGGAC
ACTGAGGCAATCCTGGTTAGAACTCCAGCTAATGATCAAACAGTGCTTGAAGGACCCTGGCTCTGGTTCTGTGGCCGAAATGAACAACTT
ACTGGACAATATTGCAAAGGCAACAATAGAGGTATTCCAGCAGTCTGCAGACCTAAATAATTCTTCTAATTCTGGCATGAGCCTCTTCAA
CCCAAACAGTATTGGAAGTGCTGATACAAGTAGCACGAGACAGAATGGAATAAAGACATTCCTAAGTTCCTCCGAACGCAGGGGTGTATG
GTTGGTGGCCCCCCTCATCGCCAGGTTGCCAACTTCTGTGCAAGGAAGAGTGCTGAAAGCCGCTGGGGAAGAGCTGGAGAAGGGACAGCA
CTTGGGTTCTTCTTCCAAAAAGGAAAGGGACAGACAGAAACAGAAAAGTATGTCTCTTTTGAGTCAACAACCCTTCCTCTCACTGGTACT
TACCTGCCTTAAGGGACAAGATGAACAAAGGGAAGGCCTCCTAACATCTCTCCAGAATCAAGTTAACCAGATTTTAAGTAACTGGAGAGA
AGAACGATACCAAGATGACATAAAAGCGCGGCAGATGATGCACGAAGCATTGCAACTCCGCCTAAATTTGGTAGGAGGAATGTTTGACAC
GGTGCAGAGGAGCACCCAGTGGACTACAGACTGGGCCCTGCTACTCCTTCAGATCATTACTTCAGGAACTGTTGACATGCACACTAACAA
TGAATTATTCACAACAGTTCTTGACATGCTGGGTGTTTTAATCAATGGAACGTTAGCCTCTGACCTATCAAATGCATCCCCTGGGGGATC
TGAAGAGAACAAGCGTGCATACATGAATTTAGTAAAGAAACTGAAAAAAGAGCTAGGAGACAAGCGATCAGAAAGTATTGACAAAGTTCG
ACAGTTACTACCTTTGCCGAAACAGACATGTGATGTCATCACTTGTGAACCTATGGGTTCCTTGATTGACACAAAAGGAAACAAAATTGC
TGGATTTGACTCTATAGATAAAAAACAGGGTCTCCAGGTCTCTACGAAGCAGAAGGTGTCCCCGTGGGACTTGTTTGAGGGTCAGAAGAA
CCCAGCTCCTTTGTCCTGGGCCTGGTTTGGGACAGTCCGAGTGGACCGAAGAGTGATCAAGTACGAGGAGCAGCATCACCTCCTGCTGTA
TCACACACACCCCATGCCCAAGCCCCGCAGTTACTACCTCCAGCCACTGCCCCTGCCTCCTGAGGAGGAAGAGGAAGAGCCCACATCTCC
AGTTTCTCAGGAACCAGAAAGGAAGTCCGCTGAGCTGTCAGATCAGGGAAAAACCACAACAGATGAAGAAAAGAAAACAAAAGGAAGGAA
GCGCAAGACGAAATCTAGCTCAAGAGTTGATGAATATCCACAGAGCAACATATACCGAGTGCCTCCTAATTACTCGCCTATCTCCTCCCA
AATGATGCACCATCCACAGTCCACCTTGTGGGGTTACAACCTCGTGGGCCAGCCCCAGCAGCCCGGCTTTTTCCTTCAGAACCAATCTCT
TACTCCAGGTGGCTCCAGATTGGACCCTGCAGGCTCCTTTGTCCCAACCAACACCAAACAAGCTCTGTCAAACATGCTACAGCGGCGCTC
AGGCGCCATGATGCAGCCGCCTTCTCTTCATGCAATCACATCGCAGCAGCAGTTGATACAGATGAAGCTTCTGCAGCAGCAGCAGCAACA
GCGACTTCTCAGGCAAGCCCAGACTCGGCCTTTCCAACAGGGCCAGCCGGGGGACCAGGCTGCTCTCTTTGCTGCGCAAGCACGGCCCTC
CCCTCAGCTCCCTCAGTATCCAGGGCTGCAGCAAGCACAGACCATGCCACAGGGCTATACAATGTATGGGACACAGATGCCTTTGCAGCA
GACATCGCAGCAGCAGGCTGGCAGTGTGGTCCTGTCTCCCAGCTATAACTCCAGAGCCTATCCGGCCGCACATTCCAACCCCGTGCTAAT
GGAAAGACTCAGACAGATTCAGCAGCAGCCGAGTGGCTATGTTCAGCAGCAGGCCTCGCCGTACCTGCAGCCCCTGACTGGCTCTCAGAG
ACTGAACCATCAGGCTCTACAGCAGAGCCCTCTGGTGGGCGGGGGAATTGATGCTGTGCTGACTTCTGCACATCCAAACCTTCCCTCCGT
GCCCCTGCCTCAGGATCCCATGAGACCCAGACAGCCGCAAGTTCGACAGCAGCAGAGACTCCTCCAGATGCAGCAGCCCCAGCAGCCCCA
GCCCCAGCAGCCTCCCCAGCCCCAGCAGTCCTCGCAGTCCCAGAGTCAGACCCTTGGTCTCCAAGCAATGCAGCCCCAGCAGCCCTTGTT
TCCCAGGCAAGGCTTGCAGCAGACCCAGCAGCAGCAGCAGACGGCCGCCTTGGTGCGGCAGCTCCAGAAGCAGCTTTCCAGCAACCAGCC
ACAGCAAGGAGTGACTCCGTATGGGCATCCTTCACACTTCTGAATCTGCAAGAGGAGAAGACATGACGTTTTATGTTTGCACTGAAAAAC
AGAAAATCAAATTTAATGCATTAGTCATCTTAAAAATGTCCCTTTTTTTCATTTCTTTGACATTTTACTATATTTTATGCTACATCTCAC
AAAAAAAAAAAAAGGTGTTTAAACAAAAAGCCAAGGAGAAGTTGTGGTTTGATTTTGTTGAATTCACCTTTAAAGTAGGTTTACAAATGT
GAATCATGCAGGCAGGCCTACTCCCGGAAGAGTGTGCTAGCAGACCTTTTGAAATTGGTGCTTTTTTTGAATCTCACATTTCTAGAAAGA
ATGGATTATGATGGATCTAAGGTATTTATGTATTTCATTCATTAATGATGACGTTGTTTTTTTTTTTTTAATTTTATTTTCCAAACTGTG
CTGGACCAAACTACTGATTTGAAAGGCATGTCAGATCTTGACAGAAACATGGCCTGTTTATTCTGCATTCACCTGTGATGGTGAAACGGA
CATTTATTTGCATCGCTCTAATTTGAAATGTTTGTAATCTCATAAGCACTTTATAAACTTTGTTCTTATTTATGTAGGACTCTTCTTTGC
TTTTGTTGTGGTCAAAAGGTGCTGAAACAGATTGTTGCTTCGTACTTAAACTTCTTAAACCAAGAACCTAAACCAAGGTTTCTTTGAGAG
CCGCCCTAAGATGTGCGGAAACCTGTTAGAAGTAGCTGTACTCAAATTTGTTTTGAGGCAAGATCATTGATGAGAGTCATTGTGAAGGTA
CAACATGTAAATCCTAAAGGCCTGAAAGAACTGCAGTGGAATCGTCCAACTATTTATTGCCAGTTTTGGTTCTCCTGAACCTTATGCCAC
CTTAAGGGGAAAAAAAAATCCAGTAGCTGGCTTGAGATTCCAGTGCTCACACTTGACATGGTTTCCAGAGAATCTGGCCCCAAAGTCCAG
AAGGCTCTGGTTTTCATAAAAGGTGTATTTGCTGTTTATTTTGTATGGTAAGTATTTGCTCTTTTGAATTTAATTATTACTGTCAGTGTC
AGTCTTGGTTGTGTATTGCATATACTGTATTTATAAATTGGTGCAAAAAGCACAAGTAAATTATACATCAAATTTATTATAAAGAAATAG
TAACTATTTTAACTTTGTTCAAGTATGTGGTAATTTGCTCCTATTAGAGTAAAAAAGAAACCAGTAAATTATCAGTTTGTGTAACTTAAG
AGTATTCTATATAATATTTTTTTAGATTTAGATGCATAAAATTTTGAATGTGAAAATTGCAGGGCATTTTAAAACATATGTGGGGGATAT
TTTCCCATGTTCTCTGTTATTTCATTTTCTTTTGCCATATGATTTTACATATAATATAGTCAAGCATACTGTGAATAGACTTGTCTATAA
TGAGCAGACCATGTAAATCTACTTTTTTTAAAATGTAGCTAGTACAACTTTAGTAGACATTTTCTTTTGCAAATCATTATCTATAAATAA
TTTATATCTTCCTGGGTGAGTTACTCATTGCAAAGTTTGACTCATGCAAATGACCTCAAATACATGTCAGCTTACTTTGCTGTGGCAACA
TCCATGTGAACTGCTTTGTACACTGTGAAAATATTTCACTCCAGCCTGCCCATTTTGTGTTTACTCTGGGCTGGAAAAGACTTTGCCAAA
ACATTAAAAACTATTCTTTTCACTAAATTAATAGTCTATCTGCTTTCAGAAGATGTATCATCTATCTGTACACATTTTTGCTGGTTTTGT
ATATCAGATTTTTTCCTCTCAAGAAACATACTTAGATAAGCTAATGAAGTTGTTTTCTTCAAAGTAATATATCTATATAATGACTGCATT
GGCAAATCAACCGAAATGTGAATGTTGTGCCTAGTGAGTGAGTCATGTTCCATCATTATTTCTTTCCAAATTTCTTTGCCAGTTCAGTTT
GAACCATATATTTTGTAGCTCAGCATTGCAAACAACAGTAATACTGTTTTAAGAATGAGTGTTATAATTGCATAGCATTTGTATGCACTT
TATACTTTGCAGAGGTGAGTTAAATTATTAATCATTTTGCACATGAAAGCTGTGGGGCATATCTTTTTTCTTTTTTTAGGTGAGGAAGTT
ATGCTACGACTCTAATTAATTCCACGATTCTATTGAAAGTTGAGGAATGCTGTTTTACCCCTGCGCATTATAAAGAAAATAACTAGAATT
ACTTTAGTCTTCAGATTTTCTCCCTGTTAATTCTGTATCTTGAGAGGTTTCTTTTTTTTTTTTTTTTTTTTCTTTTCTTGCAAATGCATT
CTTTTGCATTAAGATGGTCACAAGGTAAAGCCCTGTGGCAGAACCTGGTACTTTACCTTACCAGAGGAAATTACCTTAGAATAAGATGGA
GCGAGACCCCAGCTCCCCTTAAAGACAAGACCTTGAAATCAAATGGAGTCAGCTATACCTATCAATCAATCACAGTTCTTGGATATAAGA
AGCCCATAGACTCTCTTGTTTACACTGTAGGCTTTTTCTTAATAGGGTTGCATTTGTCAGTCATTGCATTTACCCTTCTTGGCCTGGAAG
TAGAGGAGATCAATGCGTAGCTTTGACCACTTCCAGCCACAGGGTACTAACATCAGACATAAGTTGCAACCAGGTCACATTTTAGGCTGA
GATGGGGCTAACTGAAAGTCAGTGTGATGAAAACCCAAGGGCGCTATTCCACATGTCTCAAATGATTGGCAGGGGCTAACTTATTAGTAA
TTCTCGGTTTTGTGCACTGAGATATCTAAGACCTATGGCATTTTTTTCCCATTTATAAAGCTCCTATAATTCTTAAGTAAGTACTAGGTG
AATGTTTGAATAGATGCTGGAGAAATTACACTGGAAAACCCCACCCCTAGATTTAGATAAGATCAATCATTTAATATTCCCCAAATTAAT
TCAGGTTGAATTAAGCATGTAATATAAATTCAGTGAATTACAAAAACACATTTTGTGTAGGATTGATCAGATTTTAAATACAGTGAAACT
TCATTATATATAATAGACCTAGACCCTCCCAAGCATTTTCCCATCCCATAAAGAATTAATGAAATGAAATGCTTATAGAGCAACGATTCC
TGCTCAGAAAAATTTCCTTATAAACAGCTCCAAACCAGGGGTGCCTGAGCTAGATTTTAAAGTTATAAAGAAGTTTCATTGTATTTTTAA
AACCTTTTTAATGGGTGTATTTGGACAAAAATAACCCCCTTTTCACATTTTATGATGTGCAGGTATTACATTGCTTTTTACATGTGGAAA
AGTGAGCCTGCATTTATTTTTAAATGCAGTTATTAAAACATTTTTGTATTCCCCATCAATGAAAATTTTCAGTGTGAACAAATGGTGAAT
CATAAGACAGTTCAGTGCTTATTTTCTGTAGGTTTTAGCAAAAAAATTTATAAACCACAAAATATTTATACATCAGGATGGTAAATTTAC
ATCATAAAGATTGCAGATTTAATATTTTCCATTGTCTCTGTTCTGAGTGCCATGCTTGTAACATTGATAGGAGGTGGACACTAGGCAACT
GGTATTAGAAGTTCATTTTTTTACTGAAAAATTCAGGTACATTAGCCATTTGTTATTTTATAGTGAACCGTTTCAATGTTTGTTTATTGT
TATTTGTTGGCAAAATAAAAGTGCCTTAAGTTAAAAGTTTGTTTTGAGATCCATTAAATAAATCAGTATCATCAGTTCATAATGCATTTA
TTTACAAGTCCTTTTATTTTGCATGTTCATTGTAAATTTAATACTGTAAATGTATTCAAATTCATTTACATGCCTATGGCTGCCTTTGAT
TAAACTTCTTCCAAAAAATAAATTCTGCCCAGATGTTGTTGACTTTATTATTTCATGTCAGATTACTTGAATATACGTTGCTGCATAATC
ACTACCAAGTGGGTTCTTTGCTGTGCATTTGTATATCCCAGAATCGGAGGTTTGGGGATTCTGAATGACTAGGGTACCTTGTAAGTGAAG
CTGCTCACTTCCATGTGTCCTCTCTTTACTTGCCGTTGAGAGAAGGGAGTGGTCAGGCATCTCCCATGTGATTTCTGGCTTGGGAACTCC
CAAGGCCACACAGTGGAGCTGAAAGGCTGCCCCTGTCCTGGTGACAATACTCCTGGGTGGACGATTTGTAATTCGGGGAGGGTAGGCTAC

>75258_75258_2_ROBO1-MED12L_ROBO1_chr3_78987751_ENST00000464233_MED12L_chr3_150911277_ENST00000474524_length(amino acids)=1485AA_BP=
MPGESCENANTSLGRRMSVNCEKLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKD
ILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPA
LNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILA
YLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCM
GHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPS
LLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLK
NDDFTMRGLRCDGNADDIWTASQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQL
ICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSL
FNPNSIGSADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSL
VLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHT
NNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNK
IAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPT
SPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGFFLQNQ
SLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQAR
PSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTSQQQAGSVVLSPSYNSRAYPAAHSNPVLMERLRQIQQQPSGYVQQQASPYLQPLTGS
QRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVPLPQDPMRPRQPQVRQQQRLLQMQQPQQPQPQQPPQPQQSSQSQSQTLGLQAMQPQQP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ROBO1-MED12L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ROBO1-MED12L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ROBO1-MED12L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource