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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ROCK1-ABHD3 (FusionGDB2 ID:75294)

Fusion Gene Summary for ROCK1-ABHD3

Fusion gene summary

Fusion gene information	Fusion gene name: ROCK1-ABHD3
	Fusion gene ID: 75294
		Hgene	Tgene
	Gene symbol	ROCK1	ABHD3
	Gene ID	6093	171586
	Gene name	Rho associated coiled-coil containing protein kinase 1	abhydrolase domain containing 3, phospholipase
	Synonyms	P160ROCK\|ROCK-I	LABH3
	Cytomap	18q11.1	18q11.2
	Type of gene	protein-coding	protein-coding
	Description	rho-associated protein kinase 1p160 ROCK-1renal carcinoma antigen NY-REN-35	phospholipase ABHD3abhydrolase domain containing 3abhydrolase domain-containing protein 3alpha/beta hydrolase domain containing protein 3lung alpha/beta hydrolase 3
	Modification date	20200322	20200313
	UniProtAcc	.	Q8WU67
	Ensembl transtripts involved in fusion gene	ENST00000399799,	ENST00000578270, ENST00000579875, ENST00000580981, ENST00000289119,
Fusion gene scores	* DoF score	24 X 16 X 12=4608	8 X 11 X 6=528
	# samples	31	11
	** MAII score	log2(31/4608*10)=-3.89380059616807 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/528*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ROCK1 [Title/Abstract] AND ABHD3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ROCK1(18690779)-ABHD3(19283708), # samples:3
Anticipated loss of major functional domain due to fusion event.	ROCK1-ABHD3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. ROCK1-ABHD3 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ROCK1	GO:0006468	protein phosphorylation	23093407
Hgene	ROCK1	GO:0007159	leukocyte cell-cell adhesion	12082081
Hgene	ROCK1	GO:0018105	peptidyl-serine phosphorylation	18573880
Hgene	ROCK1	GO:0022614	membrane to membrane docking	12082081
Hgene	ROCK1	GO:0030334	regulation of cell migration	23093407
Hgene	ROCK1	GO:0032091	negative regulation of protein binding	18573880
Hgene	ROCK1	GO:0032956	regulation of actin cytoskeleton organization	25911094
Hgene	ROCK1	GO:0050900	leukocyte migration	12082081
Hgene	ROCK1	GO:0050901	leukocyte tethering or rolling	12082081
Hgene	ROCK1	GO:0070507	regulation of microtubule cytoskeleton organization	23093407

Fusion gene breakpoints across ROCK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ABHD3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-C8-A12P-01A	ROCK1	chr18	18690779	-	ABHD3	chr18	19282459	-
ChimerDB4	BRCA	TCGA-C8-A12P-01A	ROCK1	chr18	18690779	-	ABHD3	chr18	19283708	-
ChimerDB4	LUSC	TCGA-85-8048-01A	ROCK1	chr18	18690779	-	ABHD3	chr18	19244191	-

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Fusion Gene ORF analysis for ROCK1-ABHD3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000399799	ENST00000578270	ROCK1	chr18	18690779	-	ABHD3	chr18	19282459	-
5CDS-5UTR	ENST00000399799	ENST00000578270	ROCK1	chr18	18690779	-	ABHD3	chr18	19283708	-
5CDS-5UTR	ENST00000399799	ENST00000578270	ROCK1	chr18	18690779	-	ABHD3	chr18	19244191	-
5CDS-5UTR	ENST00000399799	ENST00000579875	ROCK1	chr18	18690779	-	ABHD3	chr18	19282459	-
5CDS-5UTR	ENST00000399799	ENST00000579875	ROCK1	chr18	18690779	-	ABHD3	chr18	19283708	-
5CDS-5UTR	ENST00000399799	ENST00000579875	ROCK1	chr18	18690779	-	ABHD3	chr18	19244191	-
5CDS-intron	ENST00000399799	ENST00000580981	ROCK1	chr18	18690779	-	ABHD3	chr18	19244191	-
Frame-shift	ENST00000399799	ENST00000289119	ROCK1	chr18	18690779	-	ABHD3	chr18	19282459	-
Frame-shift	ENST00000399799	ENST00000580981	ROCK1	chr18	18690779	-	ABHD3	chr18	19282459	-
In-frame	ENST00000399799	ENST00000289119	ROCK1	chr18	18690779	-	ABHD3	chr18	19283708	-
In-frame	ENST00000399799	ENST00000289119	ROCK1	chr18	18690779	-	ABHD3	chr18	19244191	-
In-frame	ENST00000399799	ENST00000580981	ROCK1	chr18	18690779	-	ABHD3	chr18	19283708	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000399799	ROCK1	chr18	18690779	-	ENST00000289119	ABHD3	chr18	19283708	-	2796	1034	899	2101	400
ENST00000399799	ROCK1	chr18	18690779	-	ENST00000580981	ABHD3	chr18	19283708	-	2606	1034	899	1942	347
ENST00000399799	ROCK1	chr18	18690779	-	ENST00000289119	ABHD3	chr18	19244191	-	2403	1034	899	1708	269

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000399799	ENST00000289119	ROCK1	chr18	18690779	-	ABHD3	chr18	19283708	-	0.001850683	0.9981494
ENST00000399799	ENST00000580981	ROCK1	chr18	18690779	-	ABHD3	chr18	19283708	-	0.001335822	0.99866414
ENST00000399799	ENST00000289119	ROCK1	chr18	18690779	-	ABHD3	chr18	19244191	-	0.001233218	0.9987668

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Fusion Genomic Features for ROCK1-ABHD3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ROCK1-ABHD3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:18690779/chr18:19283708)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ABHD3 Q8WU67
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids. {ECO:0000250\|UniProtKB:Q91ZH7}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ABHD3

chr18:18690779

chr18:19283708

ENST00000289119

140_233

410.0

Domain

AB hydrolase-1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ROCK1

chr18:18690779

chr18:19244191

ENST00000399799

1011_1102

1355.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ROCK1

chr18:18690779

chr18:19244191

ENST00000399799

422_692

1355.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ROCK1

chr18:18690779

chr18:19283708

ENST00000399799

1011_1102

1355.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ROCK1

chr18:18690779

chr18:19283708

ENST00000399799

422_692

1355.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ROCK1

chr18:18690779

chr18:19244191

ENST00000399799

636_980

1355.0

Compositional bias

Note=Glu-rich

Hgene

ROCK1

chr18:18690779

chr18:19283708

ENST00000399799

636_980

1355.0

Compositional bias

Note=Glu-rich

Hgene

ROCK1

chr18:18690779

chr18:19244191

ENST00000399799

1118_1317

1355.0

Domain

Hgene

ROCK1

chr18:18690779

chr18:19244191

ENST00000399799

341_409

1355.0

Domain

AGC-kinase C-terminal

Hgene

ROCK1

chr18:18690779

chr18:19244191

ENST00000399799

479_556

1355.0

Domain

REM-1

Hgene

ROCK1

chr18:18690779

chr18:19244191

ENST00000399799

76_338

1355.0

Domain

Protein kinase

Hgene

ROCK1

chr18:18690779

chr18:19244191

ENST00000399799

949_1015

1355.0

Domain

RhoBD

Hgene

ROCK1

chr18:18690779

chr18:19283708

ENST00000399799

1118_1317

1355.0

Domain

Hgene

ROCK1

chr18:18690779

chr18:19283708

ENST00000399799

341_409

1355.0

Domain

AGC-kinase C-terminal

Hgene

ROCK1

chr18:18690779

chr18:19283708

ENST00000399799

479_556

1355.0

Domain

REM-1

Hgene

ROCK1

chr18:18690779

chr18:19283708

ENST00000399799

76_338

1355.0

Domain

Protein kinase

Hgene

ROCK1

chr18:18690779

chr18:19283708

ENST00000399799

949_1015

1355.0

Domain

RhoBD

Hgene

ROCK1

chr18:18690779

chr18:19244191

ENST00000399799

82_90

1355.0

Nucleotide binding

ATP

Hgene

ROCK1

chr18:18690779

chr18:19283708

ENST00000399799

82_90

1355.0

Nucleotide binding

ATP

Hgene

ROCK1

chr18:18690779

chr18:19244191

ENST00000399799

1115_1354

1355.0

Region

Note=Auto-inhibitory

Hgene

ROCK1

chr18:18690779

chr18:19244191

ENST00000399799

707_946

1355.0

Region

SHROOM3 binding

Hgene

ROCK1

chr18:18690779

chr18:19244191

ENST00000399799

998_1010

1355.0

Region

Note=RHOA binding

Hgene

ROCK1

chr18:18690779

chr18:19283708

ENST00000399799

1115_1354

1355.0

Region

Note=Auto-inhibitory

Hgene

ROCK1

chr18:18690779

chr18:19283708

ENST00000399799

707_946

1355.0

Region

SHROOM3 binding

Hgene

ROCK1

chr18:18690779

chr18:19283708

ENST00000399799

998_1010

1355.0

Region

Note=RHOA binding

Hgene

ROCK1

chr18:18690779

chr18:19244191

ENST00000399799

1228_1281

1355.0

Zinc finger

Phorbol-ester/DAG-type

Hgene

ROCK1

chr18:18690779

chr18:19283708

ENST00000399799

1228_1281

1355.0

Zinc finger

Phorbol-ester/DAG-type

Tgene

ABHD3

chr18:18690779

chr18:19244191

ENST00000289119

140_233

185

410.0

Domain

AB hydrolase-1

Tgene

ABHD3

chr18:18690779

chr18:19244191

ENST00000289119

26_46

185

410.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ABHD3

chr18:18690779

chr18:19283708

ENST00000289119

26_46

410.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

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Fusion Gene Sequence for ROCK1-ABHD3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>75294_75294_1_ROCK1-ABHD3_ROCK1_chr18_18690779_ENST00000399799_ABHD3_chr18_19244191_ENST00000289119_length(transcript)=2403nt_BP=1034nt
GCTGGTTCCCCTTCCGAGCGTCCGCGCCCCGCATGCGCAGTCTGCCCCGGCGGTCTCCGTTTGTTTGAACAGGAAGGCGGACATATTAGT
CCCTCTCAGCCCCCCTCGCCCCACCCCCCAGGCATTCGCCGCCGCGACTCGCCCTTTCCCCGGCTGGGACCGCAGCCCCTCCCAGAAGCT
CCCCCATCAGCAGCCGCCGGGACCCAACTATCGTCTTCCTCTTCGCCCGCTCTCCAGCCTTTCCTCTGCTAAGTCTCCATCGGGCATCGA
CCTCGCCCTGCCCCACCGGACACCGTAGCAGCAGCCCCAGCAGCGACGGGACAAAATGGGAGAGTGAGGCTGTCCTGCGTGGACCAGCTC
GTGGCCGAGACTGATCGGTGCGTCGGGCCGGGCCGAGTAGAGCCGGGGACGCGGGGCTAGACCGTCTACAGCGCCTCTGAGCGGAGCGGG
CCCGGCCCGTGGCCCGAGCGGCGGCCGCAGCTGGCACAGCTCCTCACCCGCCCTTTGCTTTCGCCTTTCCTCTTCTCCCTCCCTTGTTGC
CCGGAGGGAGTCTCCACCCTGCTTCTCTTTCTCTACCCGCTCCTGCCCATCTCGGGACGGGGACCCCTCCATGGCGACGGCGGCCGGGGC
CCGCTAGACTGAAGCACCTCGCCGGAGCGACGAGGCTGGTGGCGACGGCGCTGTCGGCTGTCGTGAGGGGCTGCCGGGTGGGATGCGACT
TTGGGCGTCCGAGCGGCTGTGGGTCGCTGTTGCCCCCGGCCCGGGGTCTGGAGAGCGGAGGTCCCCTCAGTGAGGGGAAGACGGGGGAAC
CGGGCGCACCTGGTGACCCTGAGGTTCCGGCTCCTCCGCCCCGCGGCTGCGAACCCACCGCGGAGGAAGTTGGTTGAAATTGCTTTCCGC
TGCTGGTGCTGGTAAGAGGGCATTGTCACAGCAGCAGCAACATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACC
TGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTGCTGACGCCAAGGACTTATTGTTGTGCTAACACTGAAGACTTGGAGACAG
TTATTCACCATGTACACAGCCTGTACCCTTCTGCTCCTTTCCTGGCAGCAGGGGTTTCAATGGGAGGAATGCTGCTTCTAAATTACTTGG
GCAAAATTGGGTCCAAAACGCCTTTGATGGCAGCTGCAACTTTTTCCGTTGGTTGGAACACCTTCGCTTGCTCAGAGTCATTGGAAAAAC
CACTGAACTGGCTACTTTTTAATTACTATTTGACAACCTGCCTTCAGTCTTCAGTTAATAAGCACCGACATATGTTTGTAAAACAAGTTG
ATATGGATCATGTCATGAAGGCTAAATCCATCAGAGAGTTTGATAAGCGATTCACTTCAGTCATGTTTGGATACCAAACAATTGATGATT
ATTATACTGATGCCAGTCCGAGTCCTAGACTGAAGTCAGTAGGAATTCCAGTATTGTGTCTAAATTCTGTGGATGATGTTTTCTCACCCA
GTCATGCTATTCCAATAGAAACTGCTAAGCAAAATCCTAATGTTGCTTTGGTCCTTACTTCTTATGGAGGCCATATTGGTTTTCTGGAGG
GAATCTGGCCAAGACAGTCCACTTACATGGATCGTGTCTTCAAGCAATTTGTGCAAGCCATGGTTGAGCATGGACATGAACTCTCTTAAC
ATGTAGTTCTTTGGGTGCATTTTGTCTGAACCACAATTGTGAAGGCAGCTCAGCTTAGTGCACAAATTTTAACTGTTGTATATAAAGCAA
ATAAGCCAGCAGATGGGTGAAGAGGTCCAGAATGATATGCAAAAACTACTTTTTAGAGAAACAAAACAACTTTGTAGCAACAAATTAAAT
ATAGTATTAGATTGTTACTTACGTAGATTTTATTTTTACTATGCCTTACCAAGTACATCCTTAAACAAAGTAGTATGTACATGAAATTGC
ACTTAACCAAAACTATTGTGTAAAACAAATTTTAATTCCTCAGGGTTTTAATTTAAACTAGTATTTTTTTAGATTATTTGTTTTAGGTGA
TTTAATGGTACTTTAATAACTACTAAGAAATATTGGCTATTTCAATGTAAGTTATAAGGTGGTACATTCCTAAGGGTATTTATAGTTGAT
GATAACATGAAAACTGAAATAAGATAAAATACAACGTGCTAAATCTTTTATGTATTCTAACTTTAAAAGACAAGTGCAACAAAGTTAGAC
TGACTTCTATATGTGCTCTTTTACTCTGATAATATTAAATTAGGACTAACTTATGTTTTATAATGATTATAATTTACATGCTTATTTTTA

>75294_75294_1_ROCK1-ABHD3_ROCK1_chr18_18690779_ENST00000399799_ABHD3_chr18_19244191_ENST00000289119_length(amino acids)=269AA_BP=45
MLVLVRGHCHSSSNMSTGDSFETRFEKMDNLLRDPKSEVNSDCLLTPRTYCCANTEDLETVIHHVHSLYPSAPFLAAGVSMGGMLLLNYL
GKIGSKTPLMAAATFSVGWNTFACSESLEKPLNWLLFNYYLTTCLQSSVNKHRHMFVKQVDMDHVMKAKSIREFDKRFTSVMFGYQTIDD

--------------------------------------------------------------
>75294_75294_2_ROCK1-ABHD3_ROCK1_chr18_18690779_ENST00000399799_ABHD3_chr18_19283708_ENST00000289119_length(transcript)=2796nt_BP=1034nt
GCTGGTTCCCCTTCCGAGCGTCCGCGCCCCGCATGCGCAGTCTGCCCCGGCGGTCTCCGTTTGTTTGAACAGGAAGGCGGACATATTAGT
CCCTCTCAGCCCCCCTCGCCCCACCCCCCAGGCATTCGCCGCCGCGACTCGCCCTTTCCCCGGCTGGGACCGCAGCCCCTCCCAGAAGCT
CCCCCATCAGCAGCCGCCGGGACCCAACTATCGTCTTCCTCTTCGCCCGCTCTCCAGCCTTTCCTCTGCTAAGTCTCCATCGGGCATCGA
CCTCGCCCTGCCCCACCGGACACCGTAGCAGCAGCCCCAGCAGCGACGGGACAAAATGGGAGAGTGAGGCTGTCCTGCGTGGACCAGCTC
GTGGCCGAGACTGATCGGTGCGTCGGGCCGGGCCGAGTAGAGCCGGGGACGCGGGGCTAGACCGTCTACAGCGCCTCTGAGCGGAGCGGG
CCCGGCCCGTGGCCCGAGCGGCGGCCGCAGCTGGCACAGCTCCTCACCCGCCCTTTGCTTTCGCCTTTCCTCTTCTCCCTCCCTTGTTGC
CCGGAGGGAGTCTCCACCCTGCTTCTCTTTCTCTACCCGCTCCTGCCCATCTCGGGACGGGGACCCCTCCATGGCGACGGCGGCCGGGGC
CCGCTAGACTGAAGCACCTCGCCGGAGCGACGAGGCTGGTGGCGACGGCGCTGTCGGCTGTCGTGAGGGGCTGCCGGGTGGGATGCGACT
TTGGGCGTCCGAGCGGCTGTGGGTCGCTGTTGCCCCCGGCCCGGGGTCTGGAGAGCGGAGGTCCCCTCAGTGAGGGGAAGACGGGGGAAC
CGGGCGCACCTGGTGACCCTGAGGTTCCGGCTCCTCCGCCCCGCGGCTGCGAACCCACCGCGGAGGAAGTTGGTTGAAATTGCTTTCCGC
TGCTGGTGCTGGTAAGAGGGCATTGTCACAGCAGCAGCAACATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACC
TGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTGCTGAAACCCCAGTTAGTGACCGGGGGTGAGAGTTTCAGCCGCTTCCTTC
AAGACCACTGTCCCGTGGTTACAGAAACGTACTACCCGACGGTCTGGTGCTGGGAGGGTCGAGGACAGACCCTGCTTAGACCTTTCATCA
CTTCGAAGCCCCCGGTGCAGTACAGGAATGAACTTATTAAAACTGCAGATGGAGGACAGATTTCACTGGACTGGTTTGATAATGATAACA
GTACGTGTTATATGGATGCCAGCACCAGACCTACTATCTTATTGTTGCCTGGCCTCACGGGAACAAGCAAGGAGTCATATATCCTTCATA
TGATCCATCTTAGTGAAGAATTAGGATACAGATGTGTGGTTTTTAACAACAGAGGAGTGGCGGGGGAGAATCTCTTGACGCCAAGGACTT
ATTGTTGTGCTAACACTGAAGACTTGGAGACAGTTATTCACCATGTACACAGCCTGTACCCTTCTGCTCCTTTCCTGGCAGCAGGGGTTT
CAATGGGAGGAATGCTGCTTCTAAATTACTTGGGCAAAATTGGGTCCAAAACGCCTTTGATGGCAGCTGCAACTTTTTCCGTTGGTTGGA
ACACCTTCGCTTGCTCAGAGTCATTGGAAAAACCACTGAACTGGCTACTTTTTAATTACTATTTGACAACCTGCCTTCAGTCTTCAGTTA
ATAAGCACCGACATATGTTTGTAAAACAAGTTGATATGGATCATGTCATGAAGGCTAAATCCATCAGAGAGTTTGATAAGCGATTCACTT
CAGTCATGTTTGGATACCAAACAATTGATGATTATTATACTGATGCCAGTCCGAGTCCTAGACTGAAGTCAGTAGGAATTCCAGTATTGT
GTCTAAATTCTGTGGATGATGTTTTCTCACCCAGTCATGCTATTCCAATAGAAACTGCTAAGCAAAATCCTAATGTTGCTTTGGTCCTTA
CTTCTTATGGAGGCCATATTGGTTTTCTGGAGGGAATCTGGCCAAGACAGTCCACTTACATGGATCGTGTCTTCAAGCAATTTGTGCAAG
CCATGGTTGAGCATGGACATGAACTCTCTTAACATGTAGTTCTTTGGGTGCATTTTGTCTGAACCACAATTGTGAAGGCAGCTCAGCTTA
GTGCACAAATTTTAACTGTTGTATATAAAGCAAATAAGCCAGCAGATGGGTGAAGAGGTCCAGAATGATATGCAAAAACTACTTTTTAGA
GAAACAAAACAACTTTGTAGCAACAAATTAAATATAGTATTAGATTGTTACTTACGTAGATTTTATTTTTACTATGCCTTACCAAGTACA
TCCTTAAACAAAGTAGTATGTACATGAAATTGCACTTAACCAAAACTATTGTGTAAAACAAATTTTAATTCCTCAGGGTTTTAATTTAAA
CTAGTATTTTTTTAGATTATTTGTTTTAGGTGATTTAATGGTACTTTAATAACTACTAAGAAATATTGGCTATTTCAATGTAAGTTATAA
GGTGGTACATTCCTAAGGGTATTTATAGTTGATGATAACATGAAAACTGAAATAAGATAAAATACAACGTGCTAAATCTTTTATGTATTC
TAACTTTAAAAGACAAGTGCAACAAAGTTAGACTGACTTCTATATGTGCTCTTTTACTCTGATAATATTAAATTAGGACTAACTTATGTT
TTATAATGATTATAATTTACATGCTTATTTTTAAAATAGTATATGTGGACACATATATATCATTATATTAAAATAAATTCTACCATTTTA

>75294_75294_2_ROCK1-ABHD3_ROCK1_chr18_18690779_ENST00000399799_ABHD3_chr18_19283708_ENST00000289119_length(amino acids)=400AA_BP=43
MLVLVRGHCHSSSNMSTGDSFETRFEKMDNLLRDPKSEVNSDCLLKPQLVTGGESFSRFLQDHCPVVTETYYPTVWCWEGRGQTLLRPFI
TSKPPVQYRNELIKTADGGQISLDWFDNDNSTCYMDASTRPTILLLPGLTGTSKESYILHMIHLSEELGYRCVVFNNRGVAGENLLTPRT
YCCANTEDLETVIHHVHSLYPSAPFLAAGVSMGGMLLLNYLGKIGSKTPLMAAATFSVGWNTFACSESLEKPLNWLLFNYYLTTCLQSSV
NKHRHMFVKQVDMDHVMKAKSIREFDKRFTSVMFGYQTIDDYYTDASPSPRLKSVGIPVLCLNSVDDVFSPSHAIPIETAKQNPNVALVL

--------------------------------------------------------------
>75294_75294_3_ROCK1-ABHD3_ROCK1_chr18_18690779_ENST00000399799_ABHD3_chr18_19283708_ENST00000580981_length(transcript)=2606nt_BP=1034nt
GCTGGTTCCCCTTCCGAGCGTCCGCGCCCCGCATGCGCAGTCTGCCCCGGCGGTCTCCGTTTGTTTGAACAGGAAGGCGGACATATTAGT
CCCTCTCAGCCCCCCTCGCCCCACCCCCCAGGCATTCGCCGCCGCGACTCGCCCTTTCCCCGGCTGGGACCGCAGCCCCTCCCAGAAGCT
CCCCCATCAGCAGCCGCCGGGACCCAACTATCGTCTTCCTCTTCGCCCGCTCTCCAGCCTTTCCTCTGCTAAGTCTCCATCGGGCATCGA
CCTCGCCCTGCCCCACCGGACACCGTAGCAGCAGCCCCAGCAGCGACGGGACAAAATGGGAGAGTGAGGCTGTCCTGCGTGGACCAGCTC
GTGGCCGAGACTGATCGGTGCGTCGGGCCGGGCCGAGTAGAGCCGGGGACGCGGGGCTAGACCGTCTACAGCGCCTCTGAGCGGAGCGGG
CCCGGCCCGTGGCCCGAGCGGCGGCCGCAGCTGGCACAGCTCCTCACCCGCCCTTTGCTTTCGCCTTTCCTCTTCTCCCTCCCTTGTTGC
CCGGAGGGAGTCTCCACCCTGCTTCTCTTTCTCTACCCGCTCCTGCCCATCTCGGGACGGGGACCCCTCCATGGCGACGGCGGCCGGGGC
CCGCTAGACTGAAGCACCTCGCCGGAGCGACGAGGCTGGTGGCGACGGCGCTGTCGGCTGTCGTGAGGGGCTGCCGGGTGGGATGCGACT
TTGGGCGTCCGAGCGGCTGTGGGTCGCTGTTGCCCCCGGCCCGGGGTCTGGAGAGCGGAGGTCCCCTCAGTGAGGGGAAGACGGGGGAAC
CGGGCGCACCTGGTGACCCTGAGGTTCCGGCTCCTCCGCCCCGCGGCTGCGAACCCACCGCGGAGGAAGTTGGTTGAAATTGCTTTCCGC
TGCTGGTGCTGGTAAGAGGGCATTGTCACAGCAGCAGCAACATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACC
TGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTGCTGAAACCCCAGTTAGTGACCGGGGGTGAGAGTTTCAGCCGCTTCCTTC
AAGACCACTGTCCCGTGGTTACAGAAACGTACTACCCGACGGTCTGGTGCTGGGAGGGTCGAGGACAGACCCTGCTTAGACCTTTCATCA
CTTCGAAGCCCCCGGTGCAGTACAGGAATGAACTTATTAAAACTGCAGATGGAGGACAGATTTCACTGGACTGGTTTGATAATGATAACA
GTACGTGTTATATGGATGCCAGCACCAGACCTACTATCTTATTGTTGCCTGGCCTCACGGGAACAAGCAAGGAGTCATATATCCTTCATA
TGATCCATCTTAGTGAAGAATTAGGATACAGAATGCTGCTTCTAAATTACTTGGGCAAAATTGGGTCCAAAACGCCTTTGATGGCAGCTG
CAACTTTTTCCGTTGGTTGGAACACCTTCGCTTGCTCAGAGTCATTGGAAAAACCACTGAACTGGCTACTTTTTAATTACTATTTGACAA
CCTGCCTTCAGTCTTCAGTTAATAAGCACCGACATATGTTTGTAAAACAAGTTGATATGGATCATGTCATGAAGGCTAAATCCATCAGAG
AGTTTGATAAGCGATTCACTTCAGTCATGTTTGGATACCAAACAATTGATGATTATTATACTGATGCCAGTCCGAGTCCTAGACTGAAGT
CAGTAGGAATTCCAGTATTGTGTCTAAATTCTGTGGATGATGTTTTCTCACCCAGTCATGCTATTCCAATAGAAACTGCTAAGCAAAATC
CTAATGTTGCTTTGGTCCTTACTTCTTATGGAGGCCATATTGGTTTTCTGGAGGGAATCTGGCCAAGACAGTCCACTTACATGGATCGTG
TCTTCAAGCAATTTGTGCAAGCCATGGTTGAGCATGGACATGAACTCTCTTAACATGTAGTTCTTTGGGTGCATTTTGTCTGAACCACAA
TTGTGAAGGCAGCTCAGCTTAGTGCACAAATTTTAACTGTTGTATATAAAGCAAATAAGCCAGCAGATGGGTGAAGAGGTCCAGAATGAT
ATGCAAAAACTACTTTTTAGAGAAACAAAACAACTTTGTAGCAACAAATTAAATATAGTATTAGATTGTTACTTACGTAGATTTTATTTT
TACTATGCCTTACCAAGTACATCCTTAAACAAAGTAGTATGTACATGAAATTGCACTTAACCAAAACTATTGTGTAAAACAAATTTTAAT
TCCTCAGGGTTTTAATTTAAACTAGTATTTTTTTAGATTATTTGTTTTAGGTGATTTAATGGTACTTTAATAACTACTAAGAAATATTGG
CTATTTCAATGTAAGTTATAAGGTGGTACATTCCTAAGGGTATTTATAGTTGATGATAACATGAAAACTGAAATAAGATAAAATACAACG
TGCTAAATCTTTTATGTATTCTAACTTTAAAAGACAAGTGCAACAAAGTTAGACTGACTTCTATATGTGCTCTTTTACTCTGATAATATT

>75294_75294_3_ROCK1-ABHD3_ROCK1_chr18_18690779_ENST00000399799_ABHD3_chr18_19283708_ENST00000580981_length(amino acids)=347AA_BP=43
MLVLVRGHCHSSSNMSTGDSFETRFEKMDNLLRDPKSEVNSDCLLKPQLVTGGESFSRFLQDHCPVVTETYYPTVWCWEGRGQTLLRPFI
TSKPPVQYRNELIKTADGGQISLDWFDNDNSTCYMDASTRPTILLLPGLTGTSKESYILHMIHLSEELGYRMLLLNYLGKIGSKTPLMAA
ATFSVGWNTFACSESLEKPLNWLLFNYYLTTCLQSSVNKHRHMFVKQVDMDHVMKAKSIREFDKRFTSVMFGYQTIDDYYTDASPSPRLK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ROCK1-ABHD3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	ROCK1	chr18:18690779	chr18:19244191	ENST00000399799	-	1	33	368_727	31.0	1355.0	FHOD1
Hgene	ROCK1	chr18:18690779	chr18:19283708	ENST00000399799	-	1	33	368_727	31.0	1355.0	FHOD1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ROCK1-ABHD3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ROCK1-ABHD3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source