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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ROCK1-CHD2 (FusionGDB2 ID:75301)

Fusion Gene Summary for ROCK1-CHD2

Fusion gene summary

Fusion gene information	Fusion gene name: ROCK1-CHD2
	Fusion gene ID: 75301
		Hgene	Tgene
	Gene symbol	ROCK1	CHD2
	Gene ID	6093	1826
	Gene name	Rho associated coiled-coil containing protein kinase 1	DS cell adhesion molecule
	Synonyms	P160ROCK\|ROCK-I	CHD2\|CHD2-42\|CHD2-52
	Cytomap	18q11.1	21q22.2
	Type of gene	protein-coding	protein-coding
	Description	rho-associated protein kinase 1p160 ROCK-1renal carcinoma antigen NY-REN-35	Down syndrome cell adhesion molecule
	Modification date	20200322	20200313
	UniProtAcc	.	O14647
	Ensembl transtripts involved in fusion gene	ENST00000399799,	ENST00000420239, ENST00000536619, ENST00000554122, ENST00000394196, ENST00000557381,
Fusion gene scores	* DoF score	24 X 16 X 12=4608	22 X 16 X 8=2816
	# samples	31	21
	** MAII score	log2(31/4608*10)=-3.89380059616807 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(21/2816*10)=-3.74518610097117 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ROCK1 [Title/Abstract] AND CHD2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ROCK1(18600111)-CHD2(93510554), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ROCK1	GO:0006468	protein phosphorylation	23093407
Hgene	ROCK1	GO:0007159	leukocyte cell-cell adhesion	12082081
Hgene	ROCK1	GO:0018105	peptidyl-serine phosphorylation	18573880
Hgene	ROCK1	GO:0022614	membrane to membrane docking	12082081
Hgene	ROCK1	GO:0030334	regulation of cell migration	23093407
Hgene	ROCK1	GO:0032091	negative regulation of protein binding	18573880
Hgene	ROCK1	GO:0032956	regulation of actin cytoskeleton organization	25911094
Hgene	ROCK1	GO:0050900	leukocyte migration	12082081
Hgene	ROCK1	GO:0050901	leukocyte tethering or rolling	12082081
Hgene	ROCK1	GO:0070507	regulation of microtubule cytoskeleton organization	23093407
Tgene	CHD2	GO:0042327	positive regulation of phosphorylation	19196994
Tgene	CHD2	GO:0048842	positive regulation of axon extension involved in axon guidance	18585357

Fusion gene breakpoints across ROCK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CHD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-LN-A4MQ	ROCK1	chr18	18600111	-	CHD2	chr15	93510554	+

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Fusion Gene ORF analysis for ROCK1-CHD2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000399799	ENST00000420239	ROCK1	chr18	18600111	-	CHD2	chr15	93510554	+
5CDS-intron	ENST00000399799	ENST00000536619	ROCK1	chr18	18600111	-	CHD2	chr15	93510554	+
5CDS-intron	ENST00000399799	ENST00000554122	ROCK1	chr18	18600111	-	CHD2	chr15	93510554	+
In-frame	ENST00000399799	ENST00000394196	ROCK1	chr18	18600111	-	CHD2	chr15	93510554	+
In-frame	ENST00000399799	ENST00000557381	ROCK1	chr18	18600111	-	CHD2	chr15	93510554	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000399799

ROCK1

chr18

18600111

ENST00000394196

CHD2

chr15

93510554

9091

2302

899

5788

1629

ENST00000399799

ROCK1

chr18

18600111

ENST00000557381

CHD2

chr15

93510554

7359

2302

899

5521

1540

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000399799	ENST00000394196	ROCK1	chr18	18600111	-	CHD2	chr15	93510554	+	0.00108071	0.99891937
ENST00000399799	ENST00000557381	ROCK1	chr18	18600111	-	CHD2	chr15	93510554	+	0.001141021	0.9988589

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Fusion Genomic Features for ROCK1-CHD2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ROCK1	chr18	18600111	-	CHD2	chr15	93510554	+	1.55E-05	0.9999845
ROCK1	chr18	18600111	-	CHD2	chr15	93510554	+	1.55E-05	0.9999845

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ROCK1-CHD2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:18600111/chr15:93510554)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CHD2 O14647
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ROCK1

chr18:18600111

chr15:93510554

ENST00000399799

341_409

453

1355.0

Domain

AGC-kinase C-terminal

Hgene

ROCK1

chr18:18600111

chr15:93510554

ENST00000399799

76_338

453

1355.0

Domain

Protein kinase

Hgene

ROCK1

chr18:18600111

chr15:93510554

ENST00000399799

82_90

453

1355.0

Nucleotide binding

ATP

Tgene

CHD2

chr18:18600111

chr15:93510554

ENST00000394196

966_1066

666

1829.0

Compositional bias

Note=Glu-rich

Tgene

CHD2

chr18:18600111

chr15:93510554

ENST00000420239

121_139

502.0

Compositional bias

Note=Ser-rich

Tgene

CHD2

chr18:18600111

chr15:93510554

ENST00000420239

13_74

502.0

Compositional bias

Note=Ser-rich

Tgene

CHD2

chr18:18600111

chr15:93510554

ENST00000420239

966_1066

502.0

Compositional bias

Note=Glu-rich

Tgene

CHD2

chr18:18600111

chr15:93510554

ENST00000557381

966_1066

666

1740.0

Compositional bias

Note=Glu-rich

Tgene

CHD2

chr18:18600111

chr15:93510554

ENST00000394196

795_946

666

1829.0

Domain

Helicase C-terminal

Tgene

CHD2

chr18:18600111

chr15:93510554

ENST00000420239

261_353

502.0

Domain

Chromo 1

Tgene

CHD2

chr18:18600111

chr15:93510554

ENST00000420239

378_456

502.0

Domain

Chromo 2

Tgene

CHD2

chr18:18600111

chr15:93510554

ENST00000420239

496_666

502.0

Domain

Helicase ATP-binding

Tgene

CHD2

chr18:18600111

chr15:93510554

ENST00000420239

795_946

502.0

Domain

Helicase C-terminal

Tgene

CHD2

chr18:18600111

chr15:93510554

ENST00000557381

795_946

666

1740.0

Domain

Helicase C-terminal

Tgene

CHD2

chr18:18600111

chr15:93510554

ENST00000420239

617_620

502.0

Motif

Note=DEAH box

Tgene

CHD2

chr18:18600111

chr15:93510554

ENST00000420239

509_516

502.0

Nucleotide binding

ATP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ROCK1

chr18:18600111

chr15:93510554

ENST00000399799

1011_1102

453

1355.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ROCK1

chr18:18600111

chr15:93510554

ENST00000399799

422_692

453

1355.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ROCK1

chr18:18600111

chr15:93510554

ENST00000399799

636_980

453

1355.0

Compositional bias

Note=Glu-rich

Hgene

ROCK1

chr18:18600111

chr15:93510554

ENST00000399799

1118_1317

453

1355.0

Domain

Hgene

ROCK1

chr18:18600111

chr15:93510554

ENST00000399799

479_556

453

1355.0

Domain

REM-1

Hgene

ROCK1

chr18:18600111

chr15:93510554

ENST00000399799

949_1015

453

1355.0

Domain

RhoBD

Hgene

ROCK1

chr18:18600111

chr15:93510554

ENST00000399799

1115_1354

453

1355.0

Region

Note=Auto-inhibitory

Hgene

ROCK1

chr18:18600111

chr15:93510554

ENST00000399799

707_946

453

1355.0

Region

SHROOM3 binding

Hgene

ROCK1

chr18:18600111

chr15:93510554

ENST00000399799

998_1010

453

1355.0

Region

Note=RHOA binding

Hgene

ROCK1

chr18:18600111

chr15:93510554

ENST00000399799

1228_1281

453

1355.0

Zinc finger

Phorbol-ester/DAG-type

Tgene

CHD2

chr18:18600111

chr15:93510554

ENST00000394196

121_139

666

1829.0

Compositional bias

Note=Ser-rich

Tgene

CHD2

chr18:18600111

chr15:93510554

ENST00000394196

13_74

666

1829.0

Compositional bias

Note=Ser-rich

Tgene

CHD2

chr18:18600111

chr15:93510554

ENST00000557381

121_139

666

1740.0

Compositional bias

Note=Ser-rich

Tgene

CHD2

chr18:18600111

chr15:93510554

ENST00000557381

13_74

666

1740.0

Compositional bias

Note=Ser-rich

Tgene

CHD2

chr18:18600111

chr15:93510554

ENST00000394196

261_353

666

1829.0

Domain

Chromo 1

Tgene

CHD2

chr18:18600111

chr15:93510554

ENST00000394196

378_456

666

1829.0

Domain

Chromo 2

Tgene

CHD2

chr18:18600111

chr15:93510554

ENST00000394196

496_666

666

1829.0

Domain

Helicase ATP-binding

Tgene

CHD2

chr18:18600111

chr15:93510554

ENST00000557381

261_353

666

1740.0

Domain

Chromo 1

Tgene

CHD2

chr18:18600111

chr15:93510554

ENST00000557381

378_456

666

1740.0

Domain

Chromo 2

Tgene

CHD2

chr18:18600111

chr15:93510554

ENST00000557381

496_666

666

1740.0

Domain

Helicase ATP-binding

Tgene

CHD2

chr18:18600111

chr15:93510554

ENST00000394196

617_620

666

1829.0

Motif

Note=DEAH box

Tgene

CHD2

chr18:18600111

chr15:93510554

ENST00000557381

617_620

666

1740.0

Motif

Note=DEAH box

Tgene

CHD2

chr18:18600111

chr15:93510554

ENST00000394196

509_516

666

1829.0

Nucleotide binding

ATP

Tgene

CHD2

chr18:18600111

chr15:93510554

ENST00000557381

509_516

666

1740.0

Nucleotide binding

ATP

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Fusion Gene Sequence for ROCK1-CHD2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>75301_75301_1_ROCK1-CHD2_ROCK1_chr18_18600111_ENST00000399799_CHD2_chr15_93510554_ENST00000394196_length(transcript)=9091nt_BP=2302nt
GCTGGTTCCCCTTCCGAGCGTCCGCGCCCCGCATGCGCAGTCTGCCCCGGCGGTCTCCGTTTGTTTGAACAGGAAGGCGGACATATTAGT
CCCTCTCAGCCCCCCTCGCCCCACCCCCCAGGCATTCGCCGCCGCGACTCGCCCTTTCCCCGGCTGGGACCGCAGCCCCTCCCAGAAGCT
CCCCCATCAGCAGCCGCCGGGACCCAACTATCGTCTTCCTCTTCGCCCGCTCTCCAGCCTTTCCTCTGCTAAGTCTCCATCGGGCATCGA
CCTCGCCCTGCCCCACCGGACACCGTAGCAGCAGCCCCAGCAGCGACGGGACAAAATGGGAGAGTGAGGCTGTCCTGCGTGGACCAGCTC
GTGGCCGAGACTGATCGGTGCGTCGGGCCGGGCCGAGTAGAGCCGGGGACGCGGGGCTAGACCGTCTACAGCGCCTCTGAGCGGAGCGGG
CCCGGCCCGTGGCCCGAGCGGCGGCCGCAGCTGGCACAGCTCCTCACCCGCCCTTTGCTTTCGCCTTTCCTCTTCTCCCTCCCTTGTTGC
CCGGAGGGAGTCTCCACCCTGCTTCTCTTTCTCTACCCGCTCCTGCCCATCTCGGGACGGGGACCCCTCCATGGCGACGGCGGCCGGGGC
CCGCTAGACTGAAGCACCTCGCCGGAGCGACGAGGCTGGTGGCGACGGCGCTGTCGGCTGTCGTGAGGGGCTGCCGGGTGGGATGCGACT
TTGGGCGTCCGAGCGGCTGTGGGTCGCTGTTGCCCCCGGCCCGGGGTCTGGAGAGCGGAGGTCCCCTCAGTGAGGGGAAGACGGGGGAAC
CGGGCGCACCTGGTGACCCTGAGGTTCCGGCTCCTCCGCCCCGCGGCTGCGAACCCACCGCGGAGGAAGTTGGTTGAAATTGCTTTCCGC
TGCTGGTGCTGGTAAGAGGGCATTGTCACAGCAGCAGCAACATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACC
TGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTGCTGGATGGATTGGATGCTTTGGTATATGATTTGGATTTTCCTGCCTTAA
GAAAAAACAAAAATATTGACAACTTTTTAAGCAGATATAAAGACACAATAAATAAAATCAGAGATTTACGAATGAAAGCTGAAGATTATG
AAGTAGTGAAGGTGATTGGTAGAGGTGCATTTGGAGAAGTTCAATTGGTAAGGCATAAATCCACCAGGAAGGTATATGCTATGAAGCTTC
TCAGCAAATTTGAAATGATAAAGAGATCTGATTCTGCTTTTTTCTGGGAAGAAAGGGACATCATGGCTTTTGCCAACAGTCCTTGGGTTG
TTCAGCTTTTTTATGCATTCCAAGATGATCGTTATCTCTACATGGTGATGGAATACATGCCTGGTGGAGATCTTGTAAACTTAATGAGCA
ACTATGATGTGCCTGAAAAATGGGCACGATTCTATACTGCAGAAGTAGTTCTTGCATTGGATGCAATCCATTCCATGGGTTTTATTCACA
GAGATGTGAAGCCTGATAACATGCTGCTGGATAAATCTGGACATTTGAAGTTAGCAGATTTTGGTACTTGTATGAAGATGAATAAGGAAG
GCATGGTACGATGTGATACAGCGGTTGGAACACCTGATTATATTTCCCCTGAAGTATTAAAATCCCAAGGTGGTGATGGTTATTATGGAA
GAGAATGTGACTGGTGGTCGGTTGGGGTATTTTTATACGAAATGCTTGTAGGTGATACACCTTTTTATGCAGATTCTTTGGTTGGAACTT
ACAGTAAAATTATGAACCATAAAAATTCACTTACCTTTCCTGATGATAATGACATATCAAAAGAAGCAAAAAACCTTATTTGTGCCTTCC
TTACTGACAGGGAAGTGAGGTTAGGGCGAAATGGTGTAGAAGAAATCAAACGACATCTCTTCTTCAAAAATGACCAGTGGGCTTGGGAAA
CGCTCCGAGACACTGTAGCACCAGTTGTACCCGATTTAAGTAGTGACATTGATACTAGTAATTTTGATGACTTGGAAGAAGATAAAGGAG
AGGAAGAAACATTCCCTATTCCTAAAGCTTTCGTTGGCAATCAACTACCTTTTGTAGGATTTACATATTATAGCAATCGTAGATACTTAT
CTTCAGCAAATCCTAATGATAACAGAACTAGCTCCAATGCAGATAAAAGCTTGCAGGAAAGTTTGCAAAAAACAATCTATAAGCTGGAAG
AACAGCTGCATAATGAAATGCAGTTAAAAGATGAAATGGAGCAGAAGTGCAGGTTTGAATTTTGGGAAGATTTTGAAGAAGACCATGGGA
AGGGGAGAGAAAATGGCTACCAGAGTCTTCATAAGGTGCTAGAGCCTTTCCTTCTCCGGAGAGTCAAAAAAGATGTGGAGAAATCCCTTC
CTGCTAAAGTGGAACAGATTCTCAGGGTGGAGATGTCAGCCCTTCAGAAACAGTATTACAAGTGGATTCTGACCAGGAATTACAAGGCTC
TTGCCAAAGGAACAAGAGGCAGCACATCTGGTTTTCTTAATATTGTGATGGAACTGAAAAAATGTTGCAACCACTGCTATCTGATTAAAC
CCCCTGAAGAAAATGAAAGGGAAAATGGACAGGAGATTCTTCTGTCCCTCATAAGGAGCAGTGGGAAGTTGATTTTATTAGACAAACTGT
TGACAAGACTTCGAGAAAGGGGGAATCGAGTGCTTATCTTCTCTCAGATGGTGAGAATGTTGGATATCCTGGCTGAATACCTAACTATTA
AACACTATCCTTTCCAGCGTCTGGATGGTTCCATCAAGGGAGAAATCCGAAAACAGGCACTGGACCACTTCAATGCAGATGGGTCTGAGG
ACTTCTGTTTCCTGCTCTCGACAAGGGCTGGTGGCCTGGGAATCAATTTGGCTTCAGCGGACACAGTCGTCATCTTTGACTCTGACTGGA
ACCCCCAGAATGACTTGCAGGCACAAGCCCGAGCGCATAGAATTGGTCAAAAGAAGCAGGTAAATATTTACCGCTTAGTTACAAAGGGGA
CTGTGGAGGAGGAGATCATAGAACGGGCCAAAAAGAAGATGGTATTAGATCATCTGGTGATTCAGCGCATGGACACCACTGGCCGGACGA
TCCTGGAAAACAACTCAGGAAGGTCCAACTCAAATCCTTTTAATAAAGAAGAGCTGACAGCTATTTTGAAATTTGGAGCAGAGGATCTCT
TCAAAGAACTGGAAGGGGAGGAATCAGAACCTCAGGAAATGGATATAGATGAAATTTTGCGGTTGGCTGAAACGAGAGAGAATGAAGTGT
CAACAAGTGCAACAGATGAACTTCTATCACAGTTTAAGGTTGCCAACTTTGCAACAATGGAAGATGAAGAAGAGCTAGAAGAGCGTCCTC
ACAAGGACTGGGATGAGATCATTCCAGAGGAACAAAGGAAAAAAGTAGAGGAGGAAGAGCGGCAGAAGGAGCTAGAAGAAATTTATATGC
TGCCTCGAATTCGGAGTTCCACTAAAAAGGCTCAGACAAATGACAGTGACTCTGACACTGAGTCTAAGAGGCAGGCCCAGAGATCCTCTG
CTTCTGAGAGTGAAACGGAAGACTCTGATGATGACAAGAAGCCAAAGCGCAGAGGGCGTCCGAGGAGTGTGCGGAAGGACCTCGTGGAGG
GATTTACTGATGCAGAGATCCGAAGGTTCATCAAGGCTTATAAGAAGTTTGGTCTCCCTCTTGAACGGCTGGAGTGCATAGCACGTGATG
CTGAGCTGGTAGATAAGTCGGTGGCAGATCTGAAGCGCCTGGGTGAACTGATCCACAACAGCTGTGTGTCAGCAATGCAGGAATACGAAG
AGCAGCTGAAAGAAAATGCCAGCGAGGGAAAAGGACCAGGGAAAAGGAGAGGTCCAACAATCAAGATATCCGGAGTTCAGGTTAATGTGA
AATCCATTATCCAACATGAAGAGGAGTTTGAGATGCTGCATAAATCTATCCCTGTGGACCCTGAAGAAAAAAAAAAATACTGCTTAACCT
GTCGTGTCAAAGCTGCACATTTTGATGTAGAGTGGGGGGTGGAAGATGATTCTCGCCTGTTGCTGGGGATTTATGAACATGGCTATGGAA
ACTGGGAGTTAATTAAAACAGACCCAGAGCTTAAATTAACTGACAAAATTCTGCCGGTGGAGACAGATAAAAAGCCTCAGGGGAAGCAGC
TACAGACCCGAGCGGATTACTTGTTGAAGCTGCTCAGAAAGGGTCTGGAGAAGAAGGGGGCTGTGACAGGTGGGGAAGAGGCCAAATTAA
AGAAGCGGAAGCCTCGGGTAAAGAAGGAAAACAAAGTGCCCAGGCTGAAAGAGGAGCATGGAATTGAGCTTTCATCTCCTAGGCATTCAG
ATAATCCATCAGAAGAGGGAGAAGTGAAAGATGATGGCTTGGAAAAAAGTCCAATGAAAAAAAAACAGAAGAAGAAAGAGAACAAGGAGA
ACAAGGAGAAACAAATGAGTTCTAGGAAAGACAAAGAAGGGGACAAGGAAAGAAAGAAGTCAAAAGATAAGAAAGAGAAGCCTAAAAGTG
GTGATGCCAAATCTTCGAGTAAATCAAAGCGATCTCAGGGTCCTGTCCATATTACAGCAGGAAGTGAACCTGTCCCCATTGGAGAGGATG
AGGATGATGATCTGGACCAGGAGACATTCAGCATATGTAAGGAGAGGATGAGGCCCGTGAAAAAGGCACTGAAACAGCTCGACAAACCTG
ACAAGGGGCTCAACGTGCAAGAACAGCTGGAACACACCCGGAACTGCCTGCTGAAAATCGGAGACCGGATAGCCGAGTGCCTTAAAGCCT
ACTCAGATCAGGAGCACATCAAACTCTGGAGGAGGAACCTATGGATTTTTGTTTCCAAGTTTACAGAATTTGATGCTCGAAAACTGCATA
AGTTATACAAGATGGCTCATAAGAAAAGGTCTCAAGAAGAAGAGGAGCAAAAGAAGAAAGACGACGTGACTGGGGGTAAGAAACCATTTC
GTCCAGAGGCCTCAGGCTCCAGCCGGGACTCTCTGATATCTCAGTCCCATACCTCACACAACCTTCACCCTCAGAAGCCTCATTTGCCTG
CCTCCCATGGCCCACAGATGCATGGACACCCAAGAGATAACTACAATCACCCCAACAAGAGACACTTCAGTAATGCAGATCGAGGAGACT
GGCAGAGGGAAAGAAAGTTCAACTATGGTGGTGGCAACAACAATCCACCATGGGGAAGCGACAGGCACCATCAGTATGAGCAGCACTGGT
ACAAGGACCACCATTATGGGGACCGGCGACATATGGATGCCCACCGTTCCGGAAGCTATCGACCCAACAACATGTCCAGAAAGAGGCCTT
ATGACCAGTACAGCAGTGACCGAGACCACCGGGGACACAGAGATTATTATGACAGGCACCATCATGACTCCAAGCGGAGGAGATCCGATG
AATTTAGGCCTCAAAATTACCACCAGCAGGATTTCCGACGAATGTCTGATCACCGCCCCGCTATGGGCTACCATGGCCAGGGACCCTCAG
ACCATTACCGCTCTTTCCACACAGATAAACTGGGGGAATATAAACAGCCTCTACCCCCATTGCACCCTGCAGTCTCAGATCCTCGCTCAC
CCCCTTCTCAGAAATCTCCTCACGATTCCAAGTCACCCCTGGATCATAGGTCTCCTTTGGAGAGATCACTAGAACAGAAAAACAACCCAG
ATTATAACTGGAATGTTCGGAAAACATAAAGGACAGCTCGTAAAGGAGAGAGTAAGAGTCACCAAACACGTGGATATTTTTGGTCTGATC
CTACAGTAGCCGGTTATCTAGACCAGTAAGTGGAGTTTTGGACATGCTGCTGCTGTCAACTCACTGGCTGAAGGAGCACTTCAAGGAATG
GGAGGCCTTTCACTGGGTCCAGCTCTGATTCGGGTCACCACTCCTGCACTTTGGCACCCCATCCCATTCCAGCCTAGTTCTGGCCTCCCA
CTTTGACGGGCACTTGGAGGAGGAGCTGACTGTGTGTGTACCAGCTTCACTGGGATGTGTTTCCCCAGTCAAGGAACAGGGGATCTTCAG
AGTCATGAATGTTTTCTTGCCAGGGTCAGTGTTCCCAGGACCTTAGTGCATGGTCGGGGCAGGAACTGGTGCATGGAGGCTGCTGGGACC
TGGTGAACAGTGTGTGATTTGGTTGATTTGGTTCACTCTGACATGATGGATGCTGCTGATGGGGAGTGGCGAGTTGGGGCAAGCGGGTGG
GGACAAGCATAGGACTTGAAGGGGAGCAGGTACACCCCTCAAATGTGTTCTTGGGAGAAGTGATACACTCGGCCTCATTATGTGAAACCT
GTGGGTGGGGTTGGGGTGGAGAAGTAGAGAGAGGGCAACAGCTTCCACAACTGCTTCATCTCTGCCAACACTAATTTTTCCCACACTGTC
TTTGTACATTTCAGAGCTTTGGTCTCCTGAGTGGGCCTCCTTTTCCCACTGTGCCAGGGAAGGTAGGTTTCTCTGGCTGACTGAGTACTG
TGAGTGAGGCAACACTGATGCCAGCATGGGTCTTACTTGACTGGGGAGTAGGCTGAGTGAGGGGTAGGGTGGGGTAGGTGGGGAGTAGTG
TGGCCAGGGAACTGGAATCCCTGGTGGATTTCTGATTCCTGTGGTGAGAAGGAAAGCTACAGGACCTGGAGAAGGGGATGCAGAGGCAGG
CCTGCTGACCAACTTGTTGCAATCACAAAGGTGGGGGTCCTGGTGCAGGCAGTGAACAGGCTTCTAATGTGGGGTTCAGTAGTGCCAGCA
AGTGGGGGAAACTTTCAGTATTGCGCTAGGTCAACACTTCCTGCTGCATTTCCTTCCCTTTGCACAGCTTGAAGAAATAGAGTAGACAGA
ATCACACATCATGTGGTGGGCAGATGGAAATAAGTACCTGTGGTGAACAAGTTTCTACTGTAGTTGGAGATCATTAGAATTGAATTCAGT
TTCTCTTAGAATATAATCAGGTATAAACCTAAGTTAAACTTTTTCCCAAACAAGGAGCATCCAAAGACACAGTGACTTGAGCTATAGATA
GTAAAAATCATACGAGAGTTGAACTGAGTCAGGTTTAGGAAGCAAGTTTGGTTGCATCAATTAAGCAGGCTCTTTTCAATTGACTGATGC
TGGGGCCTTCAGTTTTATTCTCAGTATAGATTGCCAGTATTGTTAAGAGTATCCAAAGGCCTTTCTAGATGGAGACAGAATAACTGACTT
GAACATACAGTGTGCCTGTAAGTGTCCAGGCTCAGAGCTGGTGAAAACCCTTCTGTTGGGCGTGTGCAGGGTTAAACTCCTGAAGTAACT
TGTGAGGACTTCAGTGCTTGCTGGTGTCCTGGGCAGCACCATGAATGCCTTTACCAAGACATGCCAAGTTGGATCCCCCGAATGAAGCAG
ATGTGGCTGTGGTGTGACCCTTGCTCCCTGCTACACAGAGCATCGCAGGGCTGGCCTGTGTGGTTTCCAGATGAGGGTCTGGGTCCCGGA
AGCTTGTGTTGAGAGCTCAGTGGACCCACCCCGCTTGCTGAACCCTCACAGTTCTTGGGGTTGTCCAGCCTGGACTTGTAGCACACATGT
CCTGAAGCAAAGCTCCGGTGACTGCATGAGCCACCTGGCCACAGTCCTCCCATGGAGGGCCTGCCGTGACGCTCAGTGGAGAGGGCAGGG
CCTGTGTCTCCACTTAGGCCACACAGTGATGAGGAAACCACAGATGGAGCTTCTTGCCGATAATACTGACTCTAGCCCATGATTGCCTTG
CCCAAGCCAAAGAGGAAGGTTAGGTTGGCTTGTCGAGCCCTTGAGCGTTGGGAGATGGGGTGGGAAGGAGGTGAGCCCCTGCAGAGAGTT
GGGTAGTGTCCTTCAGGAATGAAAGGAGGGGCAAAGGAGTCACCAGAGGTCCTGCATTTCCATCAGGGTTTCCACAGTCATCAGGGCTTC
TCTCTTGAGTTGCTGATAGGAGATGTGAGTTATGCCCAGAGATGTCTTATCGTGAGGAAAAAGAAACTTCCTTTTGTTCACATTTAGGAC
TCTCAGTGCCATATGAAGTAGCAAAAGGCAGTATCGGCCAGATCAGTGTTACATTGATTCTAAAATTACAGTGTCCCCATTAGACAACTA
TTTTAGGTGCTGGAGTATGTTTGAAGAGTGTGCTGGGAAAAAGGAAGCATTTCTTCATTGATTTAAATCAGTATGAATATTATATGCCTA
AATAAAAAATTTGCACAGGTAAATTCTCTCACTTGTGAATGGGAGAAGCTGCCCCAGGAATCTGTGAGGATGGTATTCCCTGGAGTCTGG
CTTTGAAAGATTTCATTGTTGGTAGAAATAACAGGTTGAGAAAGAGGGAGTTAGCATCACCTAAAACCTGCACGTGAACAAGGGTTGACA
TGATACACTATGGCCTTAGAAAAGGGCCAGGTGAAACCCCAAGCTAATCACTGCGGTCTTTCAGAGCCGGACAGACAGGTGCCAGCAGAG
CCCGGGGCTCACTCTCCTTTCAGTCATTCCTCAGCCCTTCGAAGGGAAGCCCAAACACTTTGCACGCTGTGCTGCAGACATTCTGGCCTG
GTGTGTCTGAAAGTTGCATCAGTCCTCACGGTGCAAACACAGTTGATTTAGGAAGTCACACAATGACACTGAAATCCTACAGACCAAAAT
CCACTTGTCAGCAGGAGCAGCAGCCCAGGCCCAGCACCAGCGGTCTTCCGGCTCCTCTGAGGGCTGCCACGTTGGGCGAGGGGAGCCATG
CCAAGGGTCCAGGCTGCTTTAGGCCATCTGTGCCCCACTCATCTGGGGACAGATGGTTTTTCTTTATTGTAAAATTGTGGACTTTTAAAA
CCTGTTGACTAAACAGTAATTAATTTATATTTGTGAAAAATGCCACTGTCCTAGTGATTTCTGATGTAAATAATGTTGTTTATATAGTAT
GTATTAAATTTTCCTACATTGTAAAACTGCTGTACTTTTGATTCTTGTATATTAAAAAGTGTTACTGAGCATTTTTAGAATTGGGCTAAC

>75301_75301_1_ROCK1-CHD2_ROCK1_chr18_18600111_ENST00000399799_CHD2_chr15_93510554_ENST00000394196_length(amino acids)=1629AA_BP=467
MLVLVRGHCHSSSNMSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDY
EVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMS
NYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYG
RECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWE
TLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNADKSLQESLQKTIYKLE
EQLHNEMQLKDEMEQKCRFEFWEDFEEDHGKGRENGYQSLHKVLEPFLLRRVKKDVEKSLPAKVEQILRVEMSALQKQYYKWILTRNYKA
LAKGTRGSTSGFLNIVMELKKCCNHCYLIKPPEENERENGQEILLSLIRSSGKLILLDKLLTRLRERGNRVLIFSQMVRMLDILAEYLTI
KHYPFQRLDGSIKGEIRKQALDHFNADGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKKQVNIYRLVTKG
TVEEEIIERAKKKMVLDHLVIQRMDTTGRTILENNSGRSNSNPFNKEELTAILKFGAEDLFKELEGEESEPQEMDIDEILRLAETRENEV
STSATDELLSQFKVANFATMEDEEELEERPHKDWDEIIPEEQRKKVEEEERQKELEEIYMLPRIRSSTKKAQTNDSDSDTESKRQAQRSS
ASESETEDSDDDKKPKRRGRPRSVRKDLVEGFTDAEIRRFIKAYKKFGLPLERLECIARDAELVDKSVADLKRLGELIHNSCVSAMQEYE
EQLKENASEGKGPGKRRGPTIKISGVQVNVKSIIQHEEEFEMLHKSIPVDPEEKKKYCLTCRVKAAHFDVEWGVEDDSRLLLGIYEHGYG
NWELIKTDPELKLTDKILPVETDKKPQGKQLQTRADYLLKLLRKGLEKKGAVTGGEEAKLKKRKPRVKKENKVPRLKEEHGIELSSPRHS
DNPSEEGEVKDDGLEKSPMKKKQKKKENKENKEKQMSSRKDKEGDKERKKSKDKKEKPKSGDAKSSSKSKRSQGPVHITAGSEPVPIGED
EDDDLDQETFSICKERMRPVKKALKQLDKPDKGLNVQEQLEHTRNCLLKIGDRIAECLKAYSDQEHIKLWRRNLWIFVSKFTEFDARKLH
KLYKMAHKKRSQEEEEQKKKDDVTGGKKPFRPEASGSSRDSLISQSHTSHNLHPQKPHLPASHGPQMHGHPRDNYNHPNKRHFSNADRGD
WQRERKFNYGGGNNNPPWGSDRHHQYEQHWYKDHHYGDRRHMDAHRSGSYRPNNMSRKRPYDQYSSDRDHRGHRDYYDRHHHDSKRRRSD
EFRPQNYHQQDFRRMSDHRPAMGYHGQGPSDHYRSFHTDKLGEYKQPLPPLHPAVSDPRSPPSQKSPHDSKSPLDHRSPLERSLEQKNNP

--------------------------------------------------------------
>75301_75301_2_ROCK1-CHD2_ROCK1_chr18_18600111_ENST00000399799_CHD2_chr15_93510554_ENST00000557381_length(transcript)=7359nt_BP=2302nt
GCTGGTTCCCCTTCCGAGCGTCCGCGCCCCGCATGCGCAGTCTGCCCCGGCGGTCTCCGTTTGTTTGAACAGGAAGGCGGACATATTAGT
CCCTCTCAGCCCCCCTCGCCCCACCCCCCAGGCATTCGCCGCCGCGACTCGCCCTTTCCCCGGCTGGGACCGCAGCCCCTCCCAGAAGCT
CCCCCATCAGCAGCCGCCGGGACCCAACTATCGTCTTCCTCTTCGCCCGCTCTCCAGCCTTTCCTCTGCTAAGTCTCCATCGGGCATCGA
CCTCGCCCTGCCCCACCGGACACCGTAGCAGCAGCCCCAGCAGCGACGGGACAAAATGGGAGAGTGAGGCTGTCCTGCGTGGACCAGCTC
GTGGCCGAGACTGATCGGTGCGTCGGGCCGGGCCGAGTAGAGCCGGGGACGCGGGGCTAGACCGTCTACAGCGCCTCTGAGCGGAGCGGG
CCCGGCCCGTGGCCCGAGCGGCGGCCGCAGCTGGCACAGCTCCTCACCCGCCCTTTGCTTTCGCCTTTCCTCTTCTCCCTCCCTTGTTGC
CCGGAGGGAGTCTCCACCCTGCTTCTCTTTCTCTACCCGCTCCTGCCCATCTCGGGACGGGGACCCCTCCATGGCGACGGCGGCCGGGGC
CCGCTAGACTGAAGCACCTCGCCGGAGCGACGAGGCTGGTGGCGACGGCGCTGTCGGCTGTCGTGAGGGGCTGCCGGGTGGGATGCGACT
TTGGGCGTCCGAGCGGCTGTGGGTCGCTGTTGCCCCCGGCCCGGGGTCTGGAGAGCGGAGGTCCCCTCAGTGAGGGGAAGACGGGGGAAC
CGGGCGCACCTGGTGACCCTGAGGTTCCGGCTCCTCCGCCCCGCGGCTGCGAACCCACCGCGGAGGAAGTTGGTTGAAATTGCTTTCCGC
TGCTGGTGCTGGTAAGAGGGCATTGTCACAGCAGCAGCAACATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACC
TGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTGCTGGATGGATTGGATGCTTTGGTATATGATTTGGATTTTCCTGCCTTAA
GAAAAAACAAAAATATTGACAACTTTTTAAGCAGATATAAAGACACAATAAATAAAATCAGAGATTTACGAATGAAAGCTGAAGATTATG
AAGTAGTGAAGGTGATTGGTAGAGGTGCATTTGGAGAAGTTCAATTGGTAAGGCATAAATCCACCAGGAAGGTATATGCTATGAAGCTTC
TCAGCAAATTTGAAATGATAAAGAGATCTGATTCTGCTTTTTTCTGGGAAGAAAGGGACATCATGGCTTTTGCCAACAGTCCTTGGGTTG
TTCAGCTTTTTTATGCATTCCAAGATGATCGTTATCTCTACATGGTGATGGAATACATGCCTGGTGGAGATCTTGTAAACTTAATGAGCA
ACTATGATGTGCCTGAAAAATGGGCACGATTCTATACTGCAGAAGTAGTTCTTGCATTGGATGCAATCCATTCCATGGGTTTTATTCACA
GAGATGTGAAGCCTGATAACATGCTGCTGGATAAATCTGGACATTTGAAGTTAGCAGATTTTGGTACTTGTATGAAGATGAATAAGGAAG
GCATGGTACGATGTGATACAGCGGTTGGAACACCTGATTATATTTCCCCTGAAGTATTAAAATCCCAAGGTGGTGATGGTTATTATGGAA
GAGAATGTGACTGGTGGTCGGTTGGGGTATTTTTATACGAAATGCTTGTAGGTGATACACCTTTTTATGCAGATTCTTTGGTTGGAACTT
ACAGTAAAATTATGAACCATAAAAATTCACTTACCTTTCCTGATGATAATGACATATCAAAAGAAGCAAAAAACCTTATTTGTGCCTTCC
TTACTGACAGGGAAGTGAGGTTAGGGCGAAATGGTGTAGAAGAAATCAAACGACATCTCTTCTTCAAAAATGACCAGTGGGCTTGGGAAA
CGCTCCGAGACACTGTAGCACCAGTTGTACCCGATTTAAGTAGTGACATTGATACTAGTAATTTTGATGACTTGGAAGAAGATAAAGGAG
AGGAAGAAACATTCCCTATTCCTAAAGCTTTCGTTGGCAATCAACTACCTTTTGTAGGATTTACATATTATAGCAATCGTAGATACTTAT
CTTCAGCAAATCCTAATGATAACAGAACTAGCTCCAATGCAGATAAAAGCTTGCAGGAAAGTTTGCAAAAAACAATCTATAAGCTGGAAG
AACAGCTGCATAATGAAATGCAGTTAAAAGATGAAATGGAGCAGAAGTGCAGGTTTGAATTTTGGGAAGATTTTGAAGAAGACCATGGGA
AGGGGAGAGAAAATGGCTACCAGAGTCTTCATAAGGTGCTAGAGCCTTTCCTTCTCCGGAGAGTCAAAAAAGATGTGGAGAAATCCCTTC
CTGCTAAAGTGGAACAGATTCTCAGGGTGGAGATGTCAGCCCTTCAGAAACAGTATTACAAGTGGATTCTGACCAGGAATTACAAGGCTC
TTGCCAAAGGAACAAGAGGCAGCACATCTGGTTTTCTTAATATTGTGATGGAACTGAAAAAATGTTGCAACCACTGCTATCTGATTAAAC
CCCCTGAAGAAAATGAAAGGGAAAATGGACAGGAGATTCTTCTGTCCCTCATAAGGAGCAGTGGGAAGTTGATTTTATTAGACAAACTGT
TGACAAGACTTCGAGAAAGGGGGAATCGAGTGCTTATCTTCTCTCAGATGGTGAGAATGTTGGATATCCTGGCTGAATACCTAACTATTA
AACACTATCCTTTCCAGCGTCTGGATGGTTCCATCAAGGGAGAAATCCGAAAACAGGCACTGGACCACTTCAATGCAGATGGGTCTGAGG
ACTTCTGTTTCCTGCTCTCGACAAGGGCTGGTGGCCTGGGAATCAATTTGGCTTCAGCGGACACAGTCGTCATCTTTGACTCTGACTGGA
ACCCCCAGAATGACTTGCAGGCACAAGCCCGAGCGCATAGAATTGGTCAAAAGAAGCAGGTAAATATTTACCGCTTAGTTACAAAGGGGA
CTGTGGAGGAGGAGATCATAGAACGGGCCAAAAAGAAGATGGTATTAGATCATCTGGTGATTCAGCGCATGGACACCACTGGCCGGACGA
TCCTGGAAAACAACTCAGGAAGGTCCAACTCAAATCCTTTTAATAAAGAAGAGCTGACAGCTATTTTGAAATTTGGAGCAGAGGATCTCT
TCAAAGAACTGGAAGGGGAGGAATCAGAACCTCAGGAAATGGATATAGATGAAATTTTGCGGTTGGCTGAAACGAGAGAGAATGAAGTGT
CAACAAGTGCAACAGATGAACTTCTATCACAGTTTAAGGTTGCCAACTTTGCAACAATGGAAGATGAAGAAGAGCTAGAAGAGCGTCCTC
ACAAGGACTGGGATGAGATCATTCCAGAGGAACAAAGGAAAAAAGTAGAGGAGGAAGAGCGGCAGAAGGAGCTAGAAGAAATTTATATGC
TGCCTCGAATTCGGAGTTCCACTAAAAAGGCTCAGACAAATGACAGTGACTCTGACACTGAGTCTAAGAGGCAGGCCCAGAGATCCTCTG
CTTCTGAGAGTGAAACGGAAGACTCTGATGATGACAAGAAGCCAAAGCGCAGAGGGCGTCCGAGGAGTGTGCGGAAGGACCTCGTGGAGG
GATTTACTGATGCAGAGATCCGAAGGTTCATCAAGGCTTATAAGAAGTTTGGTCTCCCTCTTGAACGGCTGGAGTGCATAGCACGTGATG
CTGAGCTGGTAGATAAGTCGGTGGCAGATCTGAAGCGCCTGGGTGAACTGATCCACAACAGCTGTGTGTCAGCAATGCAGGAATACGAAG
AGCAGCTGAAAGAAAATGCCAGCGAGGGAAAAGGACCAGGGAAAAGGAGAGGTCCAACAATCAAGATATCCGGAGTTCAGGTTAATGTGA
AATCCATTATCCAACATGAAGAGGAGTTTGAGATGCTGCATAAATCTATCCCTGTGGACCCTGAAGAAAAAAAAAAATACTGCTTAACCT
GTCGTGTCAAAGCTGCACATTTTGATGTAGAGTGGGGGGTGGAAGATGATTCTCGCCTGTTGCTGGGGATTTATGAACATGGCTATGGAA
ACTGGGAGTTAATTAAAACAGACCCAGAGCTTAAATTAACTGACAAAATTCTGCCGGTGGAGACAGATAAAAAGCCTCAGGGGAAGCAGC
TACAGACCCGAGCGGATTACTTGTTGAAGCTGCTCAGAAAGGGTCTGGAGAAGAAGGGGGCTGTGACAGGTGGGGAAGAGGCCAAATTAA
AGAAGCGGAAGCCTCGGGTAAAGAAGGAAAACAAAGTGCCCAGGCTGAAAGAGGAGCATGGAATTGAGCTTTCATCTCCTAGGCATTCAG
ATAATCCATCAGAAGAGGGAGAAGTGAAAGATGATGGCTTGGAAAAAAGTCCAATGAAAAAAAAACAGAAGAAGAAAGAGAACAAGGAGA
ACAAGGAGAAACAAATGAGTTCTAGGAAAGACAAAGAAGGGGACAAGGAAAGAAAGAAGTCAAAAGATAAGAAAGAGAAGCCTAAAAGTG
GTGATGCCAAATCTTCGAGTAAATCAAAGCGATCTCAGGGTCCTGTCCATATTACAGCAGGAAGTGAACCTGTCCCCATTGGAGAGGATG
AGGATGATGATCTGGACCAGGAGACATTCAGCATATGTAAGGAGAGGATGAGGCCCGTGAAAAAGGCACTGAAACAGCTCGACAAACCTG
ACAAGGGGCTCAACGTGCAAGAACAGCTGGAACACACCCGGAACTGCCTGCTGAAAATCGGAGACCGGATAGCCGAGTGCCTTAAAGCCT
ACTCAGATCAGGAGCACATCAAACTCTGGAGGAGGAACCTATGGATTTTTGTTTCCAAGTTTACAGAATTTGATGCTCGAAAACTGCATA
AGTTATACAAGATGGCTCATAAGAAAAGGTCTCAAGAAGAAGAGGAGCAAAAGAAGAAAGACGACGTGACTGGGGGTAAGAAACCATTTC
GTCCAGAGGCCTCAGGCTCCAGCCGGGACTCTCTGATATCTCAGTCCCATACCTCACACAACCTTCACCCTCAGAAGCCTCATTTGCCTG
CCTCCCATGGCCCACAGATGCATGGACACCCAAGAGATAACTACAATCACCCCAACAAGAGACACTTCAGTAATGCAGATCGAGGAGACT
GGCAGAGGGAAAGAAAGTTCAACTATGGTGGTGGCAACAACAATCCACCATGGGGAAGCGACAGGCACCATCAGTATGAGCAGCACTGGT
ACAAGGACCACCATTATGGGGACCGGCGACATATGGATGCCCACCGTTCCGGAAGCTATCGACCCAACAACATGTCCAGAAAGAGGCCTT
ATGACCAGTACAGCAGTGACCGAGACCACCGGGGACACAGAGATTATTATGACAGGTATGCAAAAGGCTGTGAGACACCAGGTGCCAACC
TTTGCCAGGAGCTGTTTCTAGGGAGAAAGTGACGTATACATGAATGTATTTATCTATCAAATTACTGAAGATCTCATCATGCATGTGTCA
GCCACAGCGAATCCCATGTCTTGGTTATAGGTTTTATGTTTTGTTTTGTGGGTCATAGGGAGCACATTTCACCTGTGCAGGAAAAGAGTT
TTCTGCCGTCTTTTGAGGAAATCTAGTGAAGAGGTCGCCATAAAATATTAGAGTCAACAACCAAAATTATTAAGCTCTGTGCGAGGCTGT
CAGCCACACTAGGTATCAGGGATCCCGAGATGGGTACCAGCCCACAGTCCTTACCTGCCACGAGCCCATAATTGAAGAGTCAAAGTCTTC
TGAAGCTGCACCCTCTTTACTTCAGTACAATGCCACCAGTAGTACGATGAGCCGAAGCTTTACATTGTGAGAGTAGCAAGTCCAGGGAGA
GCTAAAGAGGTTTTATCTGTATTTCCTAATTTCAAATCTTGGATAATTTAACCTCATAGCAGCTTTGGTTTTCCCTGGGCTGATGATGTG
CGTCATTTGCACTGTACCTTGAATTTACAGTGGGAAAATTTCATATAAACGTGTCAAAGTCGTGCTTTGTTTTTGGAAGATCTGGTAACA
GCAGCCCGCATTAGCAGAGAGCTGTAGCTGAGTAGCTGCCACCTCGTTGGGAGACTGCCCCTCGCTCCCACCCTTCTCTATTGTCTGGAC
CCAGTGGGCATCTTGCCCTGCGTTCTTCTAGTAGGTCTGTATTTCTATTTGATGTCACTTTCCTTTTGCCTGAAGGACTTTTTCTGCTGG
TGATAAACTCTTTCAGTGTTTGTATATATGCCTGAAAAAGTATTTTGCCTTCATTTTTGAAAGTAGTTTTTGCTGAGTGTATACATTTTT
GGCTTTACAGTTTCTTTCAGTGCTTTAAAGATGTACCTCTGCTATTTACTTGCATTGTTTTGTGATGAAAAATCTGTCATCCTTATCTTT
GTTCCTCTTTACATAATGTTCCTTTTAAAAAAAATCACTGATTATGATGTGCCTTGGTGTATTTTTCCTTGGTTTCTTGTGCTTGGAAAT
TTTTGAACTTCTTGGATCTGTGGGTTTATTGTTTCCATAAAATTTGGAAATTTTTACAATCTTCTTCAAATATTTTTTCTGATCCCCCAC
TCTCTCTTCTTCTTTGGAGATTCTCATTACACCTATATTAGCTTGCTTGAAGTTGTCTCACAGCTCACTTGTATTCTGTTGACTTTTAAA
AAATTATGCTTTCTGTTTCACTGTGGATAGTTTCTATTGCTACCTCTTCAAGTTCACTAATACTTTCCTTTTCAATGTCAAGACTGCTGT
GAGGCCCATCCAGTGTACTTTGCATTTTATACATTGTAGTTCTAAAAGTTCGGAAAGTTGTTTTTGGGTCTTTTTATATATGTTCTGTGT
CTAACCTTTTAAAACCTGGAACACAGATATAACAATGGTTTTGATGTCCTTGTCTGCGAATCTTATCACTTGGGTCAGTTTCAGTTGATA
CCTCCTCACTGTGGGTCTTGCTCCCCTGGTGCTTTCTGTGCCTAGTAATTTTTGTCAGATGCCAGATGTAACATTTACCTTGTTGGGTGC
TGGATATTTCTGTATTCCTGTAAGTATTCTGGAGCTTTGTTATGAGTTGCAGGTTATTTGGAAGCAGTTTCCTTTTTCAGGTCTTGCTGT
TAAGATTCGTTAGGTAGAACCAGAGCAGTGCTCAGTCAAGGGCTAATGATTGCCCACCCCCAAGGTAAAGAGCCTCATTGCACTCTACCC

>75301_75301_2_ROCK1-CHD2_ROCK1_chr18_18600111_ENST00000399799_CHD2_chr15_93510554_ENST00000557381_length(amino acids)=1540AA_BP=467
MLVLVRGHCHSSSNMSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDY
EVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMS
NYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYG
RECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWE
TLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNADKSLQESLQKTIYKLE
EQLHNEMQLKDEMEQKCRFEFWEDFEEDHGKGRENGYQSLHKVLEPFLLRRVKKDVEKSLPAKVEQILRVEMSALQKQYYKWILTRNYKA
LAKGTRGSTSGFLNIVMELKKCCNHCYLIKPPEENERENGQEILLSLIRSSGKLILLDKLLTRLRERGNRVLIFSQMVRMLDILAEYLTI
KHYPFQRLDGSIKGEIRKQALDHFNADGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKKQVNIYRLVTKG
TVEEEIIERAKKKMVLDHLVIQRMDTTGRTILENNSGRSNSNPFNKEELTAILKFGAEDLFKELEGEESEPQEMDIDEILRLAETRENEV
STSATDELLSQFKVANFATMEDEEELEERPHKDWDEIIPEEQRKKVEEEERQKELEEIYMLPRIRSSTKKAQTNDSDSDTESKRQAQRSS
ASESETEDSDDDKKPKRRGRPRSVRKDLVEGFTDAEIRRFIKAYKKFGLPLERLECIARDAELVDKSVADLKRLGELIHNSCVSAMQEYE
EQLKENASEGKGPGKRRGPTIKISGVQVNVKSIIQHEEEFEMLHKSIPVDPEEKKKYCLTCRVKAAHFDVEWGVEDDSRLLLGIYEHGYG
NWELIKTDPELKLTDKILPVETDKKPQGKQLQTRADYLLKLLRKGLEKKGAVTGGEEAKLKKRKPRVKKENKVPRLKEEHGIELSSPRHS
DNPSEEGEVKDDGLEKSPMKKKQKKKENKENKEKQMSSRKDKEGDKERKKSKDKKEKPKSGDAKSSSKSKRSQGPVHITAGSEPVPIGED
EDDDLDQETFSICKERMRPVKKALKQLDKPDKGLNVQEQLEHTRNCLLKIGDRIAECLKAYSDQEHIKLWRRNLWIFVSKFTEFDARKLH
KLYKMAHKKRSQEEEEQKKKDDVTGGKKPFRPEASGSSRDSLISQSHTSHNLHPQKPHLPASHGPQMHGHPRDNYNHPNKRHFSNADRGD
WQRERKFNYGGGNNNPPWGSDRHHQYEQHWYKDHHYGDRRHMDAHRSGSYRPNNMSRKRPYDQYSSDRDHRGHRDYYDRYAKGCETPGAN

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ROCK1-CHD2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	ROCK1	chr18:18600111	chr15:93510554	ENST00000399799	-	12	33	368_727	453.6666666666667	1355.0	FHOD1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ROCK1-CHD2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ROCK1-CHD2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source