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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:ROCK1-RNF38 (FusionGDB2 ID:75316)

Fusion Gene Summary for ROCK1-RNF38

Fusion gene summary

Fusion gene information	Fusion gene name: ROCK1-RNF38
	Fusion gene ID: 75316
		Hgene	Tgene
	Gene symbol	ROCK1	RNF38
	Gene ID	6093	152006
	Gene name	Rho associated coiled-coil containing protein kinase 1	ring finger protein 38
	Synonyms	P160ROCK\|ROCK-I	-
	Cytomap	18q11.1	9p13.2
	Type of gene	protein-coding	protein-coding
	Description	rho-associated protein kinase 1p160 ROCK-1renal carcinoma antigen NY-REN-35	E3 ubiquitin-protein ligase RNF38RING-type E3 ubiquitin transferase RNF38
	Modification date	20200322	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000399799,	ENST00000350199, ENST00000357058, ENST00000377877, ENST00000377885, ENST00000491349, ENST00000353739, ENST00000259605,
Fusion gene scores	* DoF score	24 X 16 X 12=4608	4 X 4 X 5=80
	# samples	31	5
	** MAII score	log2(31/4608*10)=-3.89380059616807 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ROCK1 [Title/Abstract] AND RNF38 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ROCK1(18690779)-RNF38(36376124), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ROCK1	GO:0006468	protein phosphorylation	23093407
Hgene	ROCK1	GO:0007159	leukocyte cell-cell adhesion	12082081
Hgene	ROCK1	GO:0018105	peptidyl-serine phosphorylation	18573880
Hgene	ROCK1	GO:0022614	membrane to membrane docking	12082081
Hgene	ROCK1	GO:0030334	regulation of cell migration	23093407
Hgene	ROCK1	GO:0032091	negative regulation of protein binding	18573880
Hgene	ROCK1	GO:0032956	regulation of actin cytoskeleton organization	25911094
Hgene	ROCK1	GO:0050900	leukocyte migration	12082081
Hgene	ROCK1	GO:0050901	leukocyte tethering or rolling	12082081
Hgene	ROCK1	GO:0070507	regulation of microtubule cytoskeleton organization	23093407
Tgene	RNF38	GO:0016567	protein ubiquitination	23973461

Fusion gene breakpoints across ROCK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RNF38 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-56-A49D-01A	ROCK1	chr18	18690779	-	RNF38	chr9	36376124	-
ChimerDB4	LUSC	TCGA-56-A49D-01A	ROCK1	chr18	18690779	-	RNF38	chr9	36390613	-
ChimerDB4	LUSC	TCGA-56-A49D	ROCK1	chr18	18690779	-	RNF38	chr9	36376124	-

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Fusion Gene ORF analysis for ROCK1-RNF38

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000399799	ENST00000350199	ROCK1	chr18	18690779	-	RNF38	chr9	36376124	-
5CDS-5UTR	ENST00000399799	ENST00000357058	ROCK1	chr18	18690779	-	RNF38	chr9	36376124	-
5CDS-5UTR	ENST00000399799	ENST00000357058	ROCK1	chr18	18690779	-	RNF38	chr9	36390613	-
5CDS-5UTR	ENST00000399799	ENST00000377877	ROCK1	chr18	18690779	-	RNF38	chr9	36376124	-
5CDS-5UTR	ENST00000399799	ENST00000377885	ROCK1	chr18	18690779	-	RNF38	chr9	36376124	-
5CDS-5UTR	ENST00000399799	ENST00000377885	ROCK1	chr18	18690779	-	RNF38	chr9	36390613	-
5CDS-5UTR	ENST00000399799	ENST00000491349	ROCK1	chr18	18690779	-	RNF38	chr9	36376124	-
5CDS-5UTR	ENST00000399799	ENST00000491349	ROCK1	chr18	18690779	-	RNF38	chr9	36390613	-
5CDS-intron	ENST00000399799	ENST00000350199	ROCK1	chr18	18690779	-	RNF38	chr9	36390613	-
5CDS-intron	ENST00000399799	ENST00000353739	ROCK1	chr18	18690779	-	RNF38	chr9	36390613	-
5CDS-intron	ENST00000399799	ENST00000377877	ROCK1	chr18	18690779	-	RNF38	chr9	36390613	-
In-frame	ENST00000399799	ENST00000259605	ROCK1	chr18	18690779	-	RNF38	chr9	36376124	-
In-frame	ENST00000399799	ENST00000259605	ROCK1	chr18	18690779	-	RNF38	chr9	36390613	-
In-frame	ENST00000399799	ENST00000353739	ROCK1	chr18	18690779	-	RNF38	chr9	36376124	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000399799	ROCK1	chr18	18690779	-	ENST00000259605	RNF38	chr9	36376124	-	5776	1034	899	2419	506
ENST00000399799	ROCK1	chr18	18690779	-	ENST00000353739	RNF38	chr9	36376124	-	5776	1034	899	2419	506
ENST00000399799	ROCK1	chr18	18690779	-	ENST00000259605	RNF38	chr9	36390613	-	5926	1034	899	2569	556

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000399799	ENST00000259605	ROCK1	chr18	18690779	-	RNF38	chr9	36376124	-	0.007385061	0.992615
ENST00000399799	ENST00000353739	ROCK1	chr18	18690779	-	RNF38	chr9	36376124	-	0.007385061	0.992615
ENST00000399799	ENST00000259605	ROCK1	chr18	18690779	-	RNF38	chr9	36390613	-	0.005170948	0.994829

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Fusion Genomic Features for ROCK1-RNF38

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ROCK1-RNF38

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:18690779/chr9:36376124)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000259605

239_404

516.0

Compositional bias

Note=Pro-rich

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000350199

239_404

433.0

Compositional bias

Note=Pro-rich

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000353739

239_404

466.0

Compositional bias

Note=Pro-rich

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000357058

239_404

433.0

Compositional bias

Note=Pro-rich

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000377885

239_404

433.0

Compositional bias

Note=Pro-rich

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000259605

239_404

516.0

Compositional bias

Note=Pro-rich

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000350199

239_404

433.0

Compositional bias

Note=Pro-rich

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000353739

239_404

466.0

Compositional bias

Note=Pro-rich

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000357058

239_404

433.0

Compositional bias

Note=Pro-rich

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000377885

239_404

433.0

Compositional bias

Note=Pro-rich

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000259605

115_131

516.0

Motif

Note=Bipartite nuclear localization signal 2

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000259605

57_71

516.0

Motif

Note=Bipartite nuclear localization signal 1

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000350199

115_131

433.0

Motif

Note=Bipartite nuclear localization signal 2

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000350199

57_71

433.0

Motif

Note=Bipartite nuclear localization signal 1

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000353739

115_131

466.0

Motif

Note=Bipartite nuclear localization signal 2

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000353739

57_71

466.0

Motif

Note=Bipartite nuclear localization signal 1

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000357058

115_131

433.0

Motif

Note=Bipartite nuclear localization signal 2

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000357058

57_71

433.0

Motif

Note=Bipartite nuclear localization signal 1

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000377885

115_131

433.0

Motif

Note=Bipartite nuclear localization signal 2

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000377885

57_71

433.0

Motif

Note=Bipartite nuclear localization signal 1

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000259605

115_131

516.0

Motif

Note=Bipartite nuclear localization signal 2

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000259605

57_71

516.0

Motif

Note=Bipartite nuclear localization signal 1

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000350199

115_131

433.0

Motif

Note=Bipartite nuclear localization signal 2

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000350199

57_71

433.0

Motif

Note=Bipartite nuclear localization signal 1

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000353739

115_131

466.0

Motif

Note=Bipartite nuclear localization signal 2

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000353739

57_71

466.0

Motif

Note=Bipartite nuclear localization signal 1

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000357058

115_131

433.0

Motif

Note=Bipartite nuclear localization signal 2

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000357058

57_71

433.0

Motif

Note=Bipartite nuclear localization signal 1

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000377885

115_131

433.0

Motif

Note=Bipartite nuclear localization signal 2

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000377885

57_71

433.0

Motif

Note=Bipartite nuclear localization signal 1

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000259605

463_504

516.0

Zinc finger

RING-type

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000350199

463_504

433.0

Zinc finger

RING-type

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000353739

463_504

466.0

Zinc finger

RING-type

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000357058

463_504

433.0

Zinc finger

RING-type

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000377885

463_504

433.0

Zinc finger

RING-type

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000259605

463_504

516.0

Zinc finger

RING-type

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000350199

463_504

433.0

Zinc finger

RING-type

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000353739

463_504

466.0

Zinc finger

RING-type

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000357058

463_504

433.0

Zinc finger

RING-type

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000377885

463_504

433.0

Zinc finger

RING-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ROCK1

chr18:18690779

chr9:36376124

ENST00000399799

1011_1102

1355.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ROCK1

chr18:18690779

chr9:36376124

ENST00000399799

422_692

1355.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ROCK1

chr18:18690779

chr9:36390613

ENST00000399799

1011_1102

1355.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ROCK1

chr18:18690779

chr9:36390613

ENST00000399799

422_692

1355.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ROCK1

chr18:18690779

chr9:36376124

ENST00000399799

636_980

1355.0

Compositional bias

Note=Glu-rich

Hgene

ROCK1

chr18:18690779

chr9:36390613

ENST00000399799

636_980

1355.0

Compositional bias

Note=Glu-rich

Hgene

ROCK1

chr18:18690779

chr9:36376124

ENST00000399799

1118_1317

1355.0

Domain

Hgene

ROCK1

chr18:18690779

chr9:36376124

ENST00000399799

341_409

1355.0

Domain

AGC-kinase C-terminal

Hgene

ROCK1

chr18:18690779

chr9:36376124

ENST00000399799

479_556

1355.0

Domain

REM-1

Hgene

ROCK1

chr18:18690779

chr9:36376124

ENST00000399799

76_338

1355.0

Domain

Protein kinase

Hgene

ROCK1

chr18:18690779

chr9:36376124

ENST00000399799

949_1015

1355.0

Domain

RhoBD

Hgene

ROCK1

chr18:18690779

chr9:36390613

ENST00000399799

1118_1317

1355.0

Domain

Hgene

ROCK1

chr18:18690779

chr9:36390613

ENST00000399799

341_409

1355.0

Domain

AGC-kinase C-terminal

Hgene

ROCK1

chr18:18690779

chr9:36390613

ENST00000399799

479_556

1355.0

Domain

REM-1

Hgene

ROCK1

chr18:18690779

chr9:36390613

ENST00000399799

76_338

1355.0

Domain

Protein kinase

Hgene

ROCK1

chr18:18690779

chr9:36390613

ENST00000399799

949_1015

1355.0

Domain

RhoBD

Hgene

ROCK1

chr18:18690779

chr9:36376124

ENST00000399799

82_90

1355.0

Nucleotide binding

ATP

Hgene

ROCK1

chr18:18690779

chr9:36390613

ENST00000399799

82_90

1355.0

Nucleotide binding

ATP

Hgene

ROCK1

chr18:18690779

chr9:36376124

ENST00000399799

1115_1354

1355.0

Region

Note=Auto-inhibitory

Hgene

ROCK1

chr18:18690779

chr9:36376124

ENST00000399799

707_946

1355.0

Region

SHROOM3 binding

Hgene

ROCK1

chr18:18690779

chr9:36376124

ENST00000399799

998_1010

1355.0

Region

Note=RHOA binding

Hgene

ROCK1

chr18:18690779

chr9:36390613

ENST00000399799

1115_1354

1355.0

Region

Note=Auto-inhibitory

Hgene

ROCK1

chr18:18690779

chr9:36390613

ENST00000399799

707_946

1355.0

Region

SHROOM3 binding

Hgene

ROCK1

chr18:18690779

chr9:36390613

ENST00000399799

998_1010

1355.0

Region

Note=RHOA binding

Hgene

ROCK1

chr18:18690779

chr9:36376124

ENST00000399799

1228_1281

1355.0

Zinc finger

Phorbol-ester/DAG-type

Hgene

ROCK1

chr18:18690779

chr9:36390613

ENST00000399799

1228_1281

1355.0

Zinc finger

Phorbol-ester/DAG-type

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Fusion Gene Sequence for ROCK1-RNF38

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>75316_75316_1_ROCK1-RNF38_ROCK1_chr18_18690779_ENST00000399799_RNF38_chr9_36376124_ENST00000259605_length(transcript)=5776nt_BP=1034nt
GCTGGTTCCCCTTCCGAGCGTCCGCGCCCCGCATGCGCAGTCTGCCCCGGCGGTCTCCGTTTGTTTGAACAGGAAGGCGGACATATTAGT
CCCTCTCAGCCCCCCTCGCCCCACCCCCCAGGCATTCGCCGCCGCGACTCGCCCTTTCCCCGGCTGGGACCGCAGCCCCTCCCAGAAGCT
CCCCCATCAGCAGCCGCCGGGACCCAACTATCGTCTTCCTCTTCGCCCGCTCTCCAGCCTTTCCTCTGCTAAGTCTCCATCGGGCATCGA
CCTCGCCCTGCCCCACCGGACACCGTAGCAGCAGCCCCAGCAGCGACGGGACAAAATGGGAGAGTGAGGCTGTCCTGCGTGGACCAGCTC
GTGGCCGAGACTGATCGGTGCGTCGGGCCGGGCCGAGTAGAGCCGGGGACGCGGGGCTAGACCGTCTACAGCGCCTCTGAGCGGAGCGGG
CCCGGCCCGTGGCCCGAGCGGCGGCCGCAGCTGGCACAGCTCCTCACCCGCCCTTTGCTTTCGCCTTTCCTCTTCTCCCTCCCTTGTTGC
CCGGAGGGAGTCTCCACCCTGCTTCTCTTTCTCTACCCGCTCCTGCCCATCTCGGGACGGGGACCCCTCCATGGCGACGGCGGCCGGGGC
CCGCTAGACTGAAGCACCTCGCCGGAGCGACGAGGCTGGTGGCGACGGCGCTGTCGGCTGTCGTGAGGGGCTGCCGGGTGGGATGCGACT
TTGGGCGTCCGAGCGGCTGTGGGTCGCTGTTGCCCCCGGCCCGGGGTCTGGAGAGCGGAGGTCCCCTCAGTGAGGGGAAGACGGGGGAAC
CGGGCGCACCTGGTGACCCTGAGGTTCCGGCTCCTCCGCCCCGCGGCTGCGAACCCACCGCGGAGGAAGTTGGTTGAAATTGCTTTCCGC
TGCTGGTGCTGGTAAGAGGGCATTGTCACAGCAGCAGCAACATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACC
TGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTGCTGAGTGAAGATAGTCCAAGTCCTAAGAGACAGCGCCTCTCTCATTCAG
TCTTTGATTATACATCAGCATCACCAGCTCCCTCACCACCAATGCGACCATGGGAGATGACATCAAATAGGCAGCCCCCTTCAGTTCGAC
CAAGCCAACATCACTTCTCAGGGGAACGATGCAACACACCTGCACGCAACAGAAGAAGTCCTCCTGTCAGGCGCCAGAGAGGAAGAAGGG
ATCGTCTGTCTCGACATAATTCCATTAGTCAAGATGAAAACTATCACCATCTCCCTTACGCACAGCAGCAAGCAATAGAGGAGCCTCGAG
CCTTCCACCCTCCGAATGTATCTCCCCGTCTGCTACATCCTGCTGCTCATCCACCCCAGCAGAATGCAGTCATGGTTGACATACATGATC
AGCTCCATCAAGGAACAGTCCCTGTTTCTTACACAGTAACAACAGTGGCACCACATGGGATTCCACTCTGCACAGGCCAGCACATCCCTG
CTTGTAGTACACAGCAGGTCCCAGGATGCTCTGTGGTTTTCAGTGGACAGCACCTCCCTGTCTGTAGTGTGCCTCCTCCAATGCTTCAGG
CATGTTCAGTTCAGCACTTACCAGTACCATATGCTGCATTCCCACCCCTTATTTCTAGTGATCCATTTCTTATACATCCTCCTCACCTTT
CTCCCCATCATCCTCCTCATTTGCCACCACCAGGCCAGTTTGTCCCTTTCCAAACACAGCAATCACGATCGCCTCTGCAAAGGATAGAAA
ATGAAGTGGAACTCTTAGGAGAACATCTTCCAGTAGGAGGTTTTACTTACCCTCCATCAGCCCACCCCCCAACATTACCTCCATCAGCTC
CCTTGCAGTTCTTAACACATGATCCTTTGCATCAGGAGGTGTCCTTTGGAGTACCTTATCCTCCATTTATGCCTCGGAGGCTTACAGGAC
GTAGTAGATACCGATCCCAGCAGCCAATACCACCTCCCCCTTATCATCCCAGCTTACTGCCATATGTGTTATCAATGCTTCCAGTGCCAC
CTGCAGTGGGCCCAACTTTCAGCTTTGAATTAGATGTAGAAGATGGAGAAGTAGAAAATTACGAGGCCCTGTTAAACCTGGCAGAGCGAC
TGGGAGAGGCAAAGCCTCGTGGACTGACTAAAGCAGATATTGAACAACTTCCTTCTTATCGGTTCAATCCTAACAACCACCAGTCAGAAC
AGACTTTGTGTGTAGTATGCATGTGTGATTTTGAGTCAAGGCAGCTACTTAGAGTCTTACCCTGTAACCACGAGTTCCATGCCAAGTGTG
TTGACAAATGGCTTAAGGCAAATCGTACTTGCCCAATTTGCCGAGCTGATGCTTCAGAAGTGCATCGGGATTCAGAATGACCAACCTAAG
AAGCACAAATTTAGTTTGGGTGTTCCTCATCACATGTATATACGGACTATCCATTGAACTTAATCTGTGTGGCTTCCAGCCCTCCCTTTA
CCAAAAGGGTCAATGGACCTTTCTTTGCACTGTGTGACTTAATCAACTATAAAAGCTTACAATTAGTCTTCACAGTTATGGGATTGTTAT
ACTAACCGTGTGATTGGAACTCCAAAGACTTTTTCTTTAGCTTAATTTTGTGTGTGCACTAACATTCCCTGGTTTTTGTGTGATCATTCC
GAGTGTTGCTGCAAGATTACAGTGGACGTGATCTTTTAGCATGTGCTTTTATAAAAAGTGGTAGCTACAGATGATATAGCAATCTACCTT
ATATAGAGCCTTCAGAAACTGTGAGTGGAAATGAATGCGCAGCGTATGACTGTTGGTGATAAGTGTATCTGTGTGAGTGTGTGCAACTAC
TTGTGTGAGGGCATGGTAGCTAACGTGTGTATGAGATCCTATATACCAGCATGTACCAAGAATGTGTGTGTAGTTTTAATTATGCTGCAA
TGTATAATCTGGTGTGTTATTTAAACAGCACTAGTACTGTACACTGGTTTTTTTCCCTTGTGTTTGCTGTTGCACACTGATTGCTGAGGG
TGCATCAATTACAAGCATTGAATACTCCATCCCCTTCCCTCCCAGTGAATGGAATGAGAAAAGCCTTCTTCCTTTGCTTCAGGCAGCTGT
CACCTTCTCTTTATTGGTGGTCCTAAGTGGGTCACTTAAGAAAAAAAAGTGTAACAAATTCTCGCTCCATGAACCTGGTTTTTTTTTATT
CTGTTGTGGAAATTTTTAAATCTCCAACTTGCTGTTTCCAAAAAGAAGGTGCAATATCATATATCATCAGTTAGCAATATTAGCATTTCA
ATCAGTGATTTGAATGTTGATACTTTTTTTTCCTTTACATTTCCAGTAAGTTTCTTACAGAAAGTACCTGTGATTTTTTTTAATGTTTAG
ATTTGTAGTCTAGTCTATTCTGAAGATATTTGATTAATATATTTCTAAGAAGACCACTAGTCCCATGAAGTCTCACCTTGTTGACTTCCA
CCAGAACAAAACCTGTTAATTCAGCTTGACTTCTCATATGTGTTCTGTGTTCAAGCTCCTGTGGGCAACTCAATTGTTTTAAGAAAACTC
TATTTCTGTTCATATTAATTCACTTGCCAGACTCCAATTCTGAAAGTTGTCTAGTTCTTCCTTCATCACACGTGCTTCTCATCGAAACCC
TGGTTTCAGGATGGATCAAGTGCTGTTACAGCTCATGTTCCTTAGACCTGATTTGTTTTGATATTTTACTGCCTTTCCTTTTAATTTTTG
TTTGAATGAGAAAAGTTTAATACAACAGGTGTCCAGAATACTTGCAGTATAAATGAAGATTTGGTTTTTGTATAAAAAAATAATGCTGTT
AAACAGGAGTTGACCTTCATTTAGTTGATGTAATACATAGCTGTATGGGGTTTTTTTTAGTAAGTTCTTTGAGCATAATTCACTTTAAAG
TCATTTTTCCAGCAATGTTTAAATTACTTTCTCATTCTTTTAGTGTATTCAACATTGTCTGCCTCTTCCTGCAGTTGATGTAATTGCTTT
GTTTGCAATAGCACAAGCTGCATTATTCCAGTCAGGACTGTGATAACTTGCTGCCAGCCCCACTCAACTTTCAGTTGGCTCTGTGTCAGT
TTTCCATTCAGTGTTAACTACTTGTTACTGCCATGCTGCTTGCCCTCCCTTGAAGTGTCTATAAGCTCATCACAGCCTAGAGTTAAGTAA
AGTCAATTCACAGAAGCACAATTTTGCCCTTTGCGAGACATTGTTGCCTCTATCTAGTCCTACAAGTAGGGTTTTGCATACTGTGTTTGC
CCCTAGGGTTGTCAGTGCATCAGAAATACTTCTAAATAGTGGTAAAAATGCACATGGTTAATGCACATGTTACTTTTAAATCATTAGGAT
ATCCCTCACCTGTTCCTGATGAATAAAAAGTGTGTTAAAGACCAAAATTCTTGGCATAATAATCAGCTACATACAAATCACATATAGTTT
AATCTTTTTTAATGAAAAAAAATCATGTTTAAAATGGCAAAAGCCCATCTTATACACTTTTATATAGCTGCAAAAAATTTATATCTGTAC
AGATCTAACACTACGACACTCAGTATTCATTTTATTGAAGCATGCAAGTAAAGCACTTTTTCTAATTTATATAGAGGTATCTAATTAACA
CAGCACATTGTACTAATGACTAGGAGTAGCAGCTTTTTCTTCTCTCCCTCTATGAATTCTTATAATGTCCCTTTTTCTGTAAGTTTTTGA
GAGGCAATTGGCAATTTAGGAGGCAGCAGGGTCTGTTTTGGTCAAATCTTGAATTTCGTTGTTGCACTCTAGTGACTGATCTTTGGGAAT
GTCTTGTCTTTGCATGGGGCTCATAGAGATGTGTGCAGACTTGCTTATTGTGGTTAGTGTGTATCAGGAACACACACACAGGTGTTCTGA
CCAGCTCAGGCTTGCCACAGTGAGCAACTCTGTGGCTAGCAAAAGAGAAGTTTATTTGTGCCCAGCCATTGGTCACCTTGGGTGATGCAC
CAGATAGCAGGCAGATGTTGGTTCATTGGCCTTCGTCCTCTTTCCTCCTAAAATAATATTGGCTTTACCATCTTAACTCAGCTGTGGGTT
TTTTGTGGGTTCTTGTTTGTTTTTTGGCATGAATTGTCATCTTTGGTGTTTTTTTAACCCCCAGCCCCTCAAAAAAATAAGGCCTCCAGG
TATCAAGATCTCATATTAGGATTTTCTGTCCTTAATTTTTTGAGCAAAATCTGGAAAATGTGAAAGCATATTTAGATTTTATATACTATC
TGAAATGTGATTTGTTAAGATTCTTAAATTTGGGCCTCTTAGAATAATTTTGAATGAGATCTACCGACTCACTTGTGAGAATATTTTTCA
CAGATTATCTTTGGGCCTTTTCATTAGAAAGCTGTTTGTTTGTCCCCCTGTTGGTACATTTGGTTACCTCATTTTGCCGTTTCAGATTGT
GAAAGCTCACAGGGGTGTTTTTTGGAATCATTTGCTGAGTCATTTTCTCAAATCATATTCCATTGTATCAGTTAACATATAGTTTTAAAT
GTATGTATTATAAATATCTGTAACCAAATCATTTGAAGGCTTGATAAATTTTTAACAAAGTTTGTACATTTTTTATGAAAGTTACTAGTA
ATGCTTTACTAAGTAGTGCAATGAATTTTTATTTTTAATCCCTGTGCCCAATTTTGGAGTTGAGAGGGTTGTTGGTAATAAATGTATGAT

>75316_75316_1_ROCK1-RNF38_ROCK1_chr18_18690779_ENST00000399799_RNF38_chr9_36376124_ENST00000259605_length(amino acids)=506AA_BP=45
MLVLVRGHCHSSSNMSTGDSFETRFEKMDNLLRDPKSEVNSDCLLSEDSPSPKRQRLSHSVFDYTSASPAPSPPMRPWEMTSNRQPPSVR
PSQHHFSGERCNTPARNRRSPPVRRQRGRRDRLSRHNSISQDENYHHLPYAQQQAIEEPRAFHPPNVSPRLLHPAAHPPQQNAVMVDIHD
QLHQGTVPVSYTVTTVAPHGIPLCTGQHIPACSTQQVPGCSVVFSGQHLPVCSVPPPMLQACSVQHLPVPYAAFPPLISSDPFLIHPPHL
SPHHPPHLPPPGQFVPFQTQQSRSPLQRIENEVELLGEHLPVGGFTYPPSAHPPTLPPSAPLQFLTHDPLHQEVSFGVPYPPFMPRRLTG
RSRYRSQQPIPPPPYHPSLLPYVLSMLPVPPAVGPTFSFELDVEDGEVENYEALLNLAERLGEAKPRGLTKADIEQLPSYRFNPNNHQSE

--------------------------------------------------------------
>75316_75316_2_ROCK1-RNF38_ROCK1_chr18_18690779_ENST00000399799_RNF38_chr9_36376124_ENST00000353739_length(transcript)=5776nt_BP=1034nt
GCTGGTTCCCCTTCCGAGCGTCCGCGCCCCGCATGCGCAGTCTGCCCCGGCGGTCTCCGTTTGTTTGAACAGGAAGGCGGACATATTAGT
CCCTCTCAGCCCCCCTCGCCCCACCCCCCAGGCATTCGCCGCCGCGACTCGCCCTTTCCCCGGCTGGGACCGCAGCCCCTCCCAGAAGCT
CCCCCATCAGCAGCCGCCGGGACCCAACTATCGTCTTCCTCTTCGCCCGCTCTCCAGCCTTTCCTCTGCTAAGTCTCCATCGGGCATCGA
CCTCGCCCTGCCCCACCGGACACCGTAGCAGCAGCCCCAGCAGCGACGGGACAAAATGGGAGAGTGAGGCTGTCCTGCGTGGACCAGCTC
GTGGCCGAGACTGATCGGTGCGTCGGGCCGGGCCGAGTAGAGCCGGGGACGCGGGGCTAGACCGTCTACAGCGCCTCTGAGCGGAGCGGG
CCCGGCCCGTGGCCCGAGCGGCGGCCGCAGCTGGCACAGCTCCTCACCCGCCCTTTGCTTTCGCCTTTCCTCTTCTCCCTCCCTTGTTGC
CCGGAGGGAGTCTCCACCCTGCTTCTCTTTCTCTACCCGCTCCTGCCCATCTCGGGACGGGGACCCCTCCATGGCGACGGCGGCCGGGGC
CCGCTAGACTGAAGCACCTCGCCGGAGCGACGAGGCTGGTGGCGACGGCGCTGTCGGCTGTCGTGAGGGGCTGCCGGGTGGGATGCGACT
TTGGGCGTCCGAGCGGCTGTGGGTCGCTGTTGCCCCCGGCCCGGGGTCTGGAGAGCGGAGGTCCCCTCAGTGAGGGGAAGACGGGGGAAC
CGGGCGCACCTGGTGACCCTGAGGTTCCGGCTCCTCCGCCCCGCGGCTGCGAACCCACCGCGGAGGAAGTTGGTTGAAATTGCTTTCCGC
TGCTGGTGCTGGTAAGAGGGCATTGTCACAGCAGCAGCAACATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACC
TGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTGCTGAGTGAAGATAGTCCAAGTCCTAAGAGACAGCGCCTCTCTCATTCAG
TCTTTGATTATACATCAGCATCACCAGCTCCCTCACCACCAATGCGACCATGGGAGATGACATCAAATAGGCAGCCCCCTTCAGTTCGAC
CAAGCCAACATCACTTCTCAGGGGAACGATGCAACACACCTGCACGCAACAGAAGAAGTCCTCCTGTCAGGCGCCAGAGAGGAAGAAGGG
ATCGTCTGTCTCGACATAATTCCATTAGTCAAGATGAAAACTATCACCATCTCCCTTACGCACAGCAGCAAGCAATAGAGGAGCCTCGAG
CCTTCCACCCTCCGAATGTATCTCCCCGTCTGCTACATCCTGCTGCTCATCCACCCCAGCAGAATGCAGTCATGGTTGACATACATGATC
AGCTCCATCAAGGAACAGTCCCTGTTTCTTACACAGTAACAACAGTGGCACCACATGGGATTCCACTCTGCACAGGCCAGCACATCCCTG
CTTGTAGTACACAGCAGGTCCCAGGATGCTCTGTGGTTTTCAGTGGACAGCACCTCCCTGTCTGTAGTGTGCCTCCTCCAATGCTTCAGG
CATGTTCAGTTCAGCACTTACCAGTACCATATGCTGCATTCCCACCCCTTATTTCTAGTGATCCATTTCTTATACATCCTCCTCACCTTT
CTCCCCATCATCCTCCTCATTTGCCACCACCAGGCCAGTTTGTCCCTTTCCAAACACAGCAATCACGATCGCCTCTGCAAAGGATAGAAA
ATGAAGTGGAACTCTTAGGAGAACATCTTCCAGTAGGAGGTTTTACTTACCCTCCATCAGCCCACCCCCCAACATTACCTCCATCAGCTC
CCTTGCAGTTCTTAACACATGATCCTTTGCATCAGGAGGTGTCCTTTGGAGTACCTTATCCTCCATTTATGCCTCGGAGGCTTACAGGAC
GTAGTAGATACCGATCCCAGCAGCCAATACCACCTCCCCCTTATCATCCCAGCTTACTGCCATATGTGTTATCAATGCTTCCAGTGCCAC
CTGCAGTGGGCCCAACTTTCAGCTTTGAATTAGATGTAGAAGATGGAGAAGTAGAAAATTACGAGGCCCTGTTAAACCTGGCAGAGCGAC
TGGGAGAGGCAAAGCCTCGTGGACTGACTAAAGCAGATATTGAACAACTTCCTTCTTATCGGTTCAATCCTAACAACCACCAGTCAGAAC
AGACTTTGTGTGTAGTATGCATGTGTGATTTTGAGTCAAGGCAGCTACTTAGAGTCTTACCCTGTAACCACGAGTTCCATGCCAAGTGTG
TTGACAAATGGCTTAAGGCAAATCGTACTTGCCCAATTTGCCGAGCTGATGCTTCAGAAGTGCATCGGGATTCAGAATGACCAACCTAAG
AAGCACAAATTTAGTTTGGGTGTTCCTCATCACATGTATATACGGACTATCCATTGAACTTAATCTGTGTGGCTTCCAGCCCTCCCTTTA
CCAAAAGGGTCAATGGACCTTTCTTTGCACTGTGTGACTTAATCAACTATAAAAGCTTACAATTAGTCTTCACAGTTATGGGATTGTTAT
ACTAACCGTGTGATTGGAACTCCAAAGACTTTTTCTTTAGCTTAATTTTGTGTGTGCACTAACATTCCCTGGTTTTTGTGTGATCATTCC
GAGTGTTGCTGCAAGATTACAGTGGACGTGATCTTTTAGCATGTGCTTTTATAAAAAGTGGTAGCTACAGATGATATAGCAATCTACCTT
ATATAGAGCCTTCAGAAACTGTGAGTGGAAATGAATGCGCAGCGTATGACTGTTGGTGATAAGTGTATCTGTGTGAGTGTGTGCAACTAC
TTGTGTGAGGGCATGGTAGCTAACGTGTGTATGAGATCCTATATACCAGCATGTACCAAGAATGTGTGTGTAGTTTTAATTATGCTGCAA
TGTATAATCTGGTGTGTTATTTAAACAGCACTAGTACTGTACACTGGTTTTTTTCCCTTGTGTTTGCTGTTGCACACTGATTGCTGAGGG
TGCATCAATTACAAGCATTGAATACTCCATCCCCTTCCCTCCCAGTGAATGGAATGAGAAAAGCCTTCTTCCTTTGCTTCAGGCAGCTGT
CACCTTCTCTTTATTGGTGGTCCTAAGTGGGTCACTTAAGAAAAAAAAGTGTAACAAATTCTCGCTCCATGAACCTGGTTTTTTTTTATT
CTGTTGTGGAAATTTTTAAATCTCCAACTTGCTGTTTCCAAAAAGAAGGTGCAATATCATATATCATCAGTTAGCAATATTAGCATTTCA
ATCAGTGATTTGAATGTTGATACTTTTTTTTCCTTTACATTTCCAGTAAGTTTCTTACAGAAAGTACCTGTGATTTTTTTTAATGTTTAG
ATTTGTAGTCTAGTCTATTCTGAAGATATTTGATTAATATATTTCTAAGAAGACCACTAGTCCCATGAAGTCTCACCTTGTTGACTTCCA
CCAGAACAAAACCTGTTAATTCAGCTTGACTTCTCATATGTGTTCTGTGTTCAAGCTCCTGTGGGCAACTCAATTGTTTTAAGAAAACTC
TATTTCTGTTCATATTAATTCACTTGCCAGACTCCAATTCTGAAAGTTGTCTAGTTCTTCCTTCATCACACGTGCTTCTCATCGAAACCC
TGGTTTCAGGATGGATCAAGTGCTGTTACAGCTCATGTTCCTTAGACCTGATTTGTTTTGATATTTTACTGCCTTTCCTTTTAATTTTTG
TTTGAATGAGAAAAGTTTAATACAACAGGTGTCCAGAATACTTGCAGTATAAATGAAGATTTGGTTTTTGTATAAAAAAATAATGCTGTT
AAACAGGAGTTGACCTTCATTTAGTTGATGTAATACATAGCTGTATGGGGTTTTTTTTAGTAAGTTCTTTGAGCATAATTCACTTTAAAG
TCATTTTTCCAGCAATGTTTAAATTACTTTCTCATTCTTTTAGTGTATTCAACATTGTCTGCCTCTTCCTGCAGTTGATGTAATTGCTTT
GTTTGCAATAGCACAAGCTGCATTATTCCAGTCAGGACTGTGATAACTTGCTGCCAGCCCCACTCAACTTTCAGTTGGCTCTGTGTCAGT
TTTCCATTCAGTGTTAACTACTTGTTACTGCCATGCTGCTTGCCCTCCCTTGAAGTGTCTATAAGCTCATCACAGCCTAGAGTTAAGTAA
AGTCAATTCACAGAAGCACAATTTTGCCCTTTGCGAGACATTGTTGCCTCTATCTAGTCCTACAAGTAGGGTTTTGCATACTGTGTTTGC
CCCTAGGGTTGTCAGTGCATCAGAAATACTTCTAAATAGTGGTAAAAATGCACATGGTTAATGCACATGTTACTTTTAAATCATTAGGAT
ATCCCTCACCTGTTCCTGATGAATAAAAAGTGTGTTAAAGACCAAAATTCTTGGCATAATAATCAGCTACATACAAATCACATATAGTTT
AATCTTTTTTAATGAAAAAAAATCATGTTTAAAATGGCAAAAGCCCATCTTATACACTTTTATATAGCTGCAAAAAATTTATATCTGTAC
AGATCTAACACTACGACACTCAGTATTCATTTTATTGAAGCATGCAAGTAAAGCACTTTTTCTAATTTATATAGAGGTATCTAATTAACA
CAGCACATTGTACTAATGACTAGGAGTAGCAGCTTTTTCTTCTCTCCCTCTATGAATTCTTATAATGTCCCTTTTTCTGTAAGTTTTTGA
GAGGCAATTGGCAATTTAGGAGGCAGCAGGGTCTGTTTTGGTCAAATCTTGAATTTCGTTGTTGCACTCTAGTGACTGATCTTTGGGAAT
GTCTTGTCTTTGCATGGGGCTCATAGAGATGTGTGCAGACTTGCTTATTGTGGTTAGTGTGTATCAGGAACACACACACAGGTGTTCTGA
CCAGCTCAGGCTTGCCACAGTGAGCAACTCTGTGGCTAGCAAAAGAGAAGTTTATTTGTGCCCAGCCATTGGTCACCTTGGGTGATGCAC
CAGATAGCAGGCAGATGTTGGTTCATTGGCCTTCGTCCTCTTTCCTCCTAAAATAATATTGGCTTTACCATCTTAACTCAGCTGTGGGTT
TTTTGTGGGTTCTTGTTTGTTTTTTGGCATGAATTGTCATCTTTGGTGTTTTTTTAACCCCCAGCCCCTCAAAAAAATAAGGCCTCCAGG
TATCAAGATCTCATATTAGGATTTTCTGTCCTTAATTTTTTGAGCAAAATCTGGAAAATGTGAAAGCATATTTAGATTTTATATACTATC
TGAAATGTGATTTGTTAAGATTCTTAAATTTGGGCCTCTTAGAATAATTTTGAATGAGATCTACCGACTCACTTGTGAGAATATTTTTCA
CAGATTATCTTTGGGCCTTTTCATTAGAAAGCTGTTTGTTTGTCCCCCTGTTGGTACATTTGGTTACCTCATTTTGCCGTTTCAGATTGT
GAAAGCTCACAGGGGTGTTTTTTGGAATCATTTGCTGAGTCATTTTCTCAAATCATATTCCATTGTATCAGTTAACATATAGTTTTAAAT
GTATGTATTATAAATATCTGTAACCAAATCATTTGAAGGCTTGATAAATTTTTAACAAAGTTTGTACATTTTTTATGAAAGTTACTAGTA
ATGCTTTACTAAGTAGTGCAATGAATTTTTATTTTTAATCCCTGTGCCCAATTTTGGAGTTGAGAGGGTTGTTGGTAATAAATGTATGAT

>75316_75316_2_ROCK1-RNF38_ROCK1_chr18_18690779_ENST00000399799_RNF38_chr9_36376124_ENST00000353739_length(amino acids)=506AA_BP=45
MLVLVRGHCHSSSNMSTGDSFETRFEKMDNLLRDPKSEVNSDCLLSEDSPSPKRQRLSHSVFDYTSASPAPSPPMRPWEMTSNRQPPSVR
PSQHHFSGERCNTPARNRRSPPVRRQRGRRDRLSRHNSISQDENYHHLPYAQQQAIEEPRAFHPPNVSPRLLHPAAHPPQQNAVMVDIHD
QLHQGTVPVSYTVTTVAPHGIPLCTGQHIPACSTQQVPGCSVVFSGQHLPVCSVPPPMLQACSVQHLPVPYAAFPPLISSDPFLIHPPHL
SPHHPPHLPPPGQFVPFQTQQSRSPLQRIENEVELLGEHLPVGGFTYPPSAHPPTLPPSAPLQFLTHDPLHQEVSFGVPYPPFMPRRLTG
RSRYRSQQPIPPPPYHPSLLPYVLSMLPVPPAVGPTFSFELDVEDGEVENYEALLNLAERLGEAKPRGLTKADIEQLPSYRFNPNNHQSE

--------------------------------------------------------------
>75316_75316_3_ROCK1-RNF38_ROCK1_chr18_18690779_ENST00000399799_RNF38_chr9_36390613_ENST00000259605_length(transcript)=5926nt_BP=1034nt
GCTGGTTCCCCTTCCGAGCGTCCGCGCCCCGCATGCGCAGTCTGCCCCGGCGGTCTCCGTTTGTTTGAACAGGAAGGCGGACATATTAGT
CCCTCTCAGCCCCCCTCGCCCCACCCCCCAGGCATTCGCCGCCGCGACTCGCCCTTTCCCCGGCTGGGACCGCAGCCCCTCCCAGAAGCT
CCCCCATCAGCAGCCGCCGGGACCCAACTATCGTCTTCCTCTTCGCCCGCTCTCCAGCCTTTCCTCTGCTAAGTCTCCATCGGGCATCGA
CCTCGCCCTGCCCCACCGGACACCGTAGCAGCAGCCCCAGCAGCGACGGGACAAAATGGGAGAGTGAGGCTGTCCTGCGTGGACCAGCTC
GTGGCCGAGACTGATCGGTGCGTCGGGCCGGGCCGAGTAGAGCCGGGGACGCGGGGCTAGACCGTCTACAGCGCCTCTGAGCGGAGCGGG
CCCGGCCCGTGGCCCGAGCGGCGGCCGCAGCTGGCACAGCTCCTCACCCGCCCTTTGCTTTCGCCTTTCCTCTTCTCCCTCCCTTGTTGC
CCGGAGGGAGTCTCCACCCTGCTTCTCTTTCTCTACCCGCTCCTGCCCATCTCGGGACGGGGACCCCTCCATGGCGACGGCGGCCGGGGC
CCGCTAGACTGAAGCACCTCGCCGGAGCGACGAGGCTGGTGGCGACGGCGCTGTCGGCTGTCGTGAGGGGCTGCCGGGTGGGATGCGACT
TTGGGCGTCCGAGCGGCTGTGGGTCGCTGTTGCCCCCGGCCCGGGGTCTGGAGAGCGGAGGTCCCCTCAGTGAGGGGAAGACGGGGGAAC
CGGGCGCACCTGGTGACCCTGAGGTTCCGGCTCCTCCGCCCCGCGGCTGCGAACCCACCGCGGAGGAAGTTGGTTGAAATTGCTTTCCGC
TGCTGGTGCTGGTAAGAGGGCATTGTCACAGCAGCAGCAACATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACC
TGCTGCGGGATCCCAAATCGGAAGTGAATTCGGATTGTTTGCTGATATCTCCCGGGGCCAATTCAGCATCTCTACCTGGCCATCCTAACA
AGGTGATTTGTGAAAGGGTGAGACTTCAGAGCCTGTTCCCTCTCCTCCCAAGTGATCAGAACACTACCGTTCAAGAGGATGCTCACTTCA
AAGCTTTCTTCCAGAGTGAAGATAGTCCAAGTCCTAAGAGACAGCGCCTCTCTCATTCAGTCTTTGATTATACATCAGCATCACCAGCTC
CCTCACCACCAATGCGACCATGGGAGATGACATCAAATAGGCAGCCCCCTTCAGTTCGACCAAGCCAACATCACTTCTCAGGGGAACGAT
GCAACACACCTGCACGCAACAGAAGAAGTCCTCCTGTCAGGCGCCAGAGAGGAAGAAGGGATCGTCTGTCTCGACATAATTCCATTAGTC
AAGATGAAAACTATCACCATCTCCCTTACGCACAGCAGCAAGCAATAGAGGAGCCTCGAGCCTTCCACCCTCCGAATGTATCTCCCCGTC
TGCTACATCCTGCTGCTCATCCACCCCAGCAGAATGCAGTCATGGTTGACATACATGATCAGCTCCATCAAGGAACAGTCCCTGTTTCTT
ACACAGTAACAACAGTGGCACCACATGGGATTCCACTCTGCACAGGCCAGCACATCCCTGCTTGTAGTACACAGCAGGTCCCAGGATGCT
CTGTGGTTTTCAGTGGACAGCACCTCCCTGTCTGTAGTGTGCCTCCTCCAATGCTTCAGGCATGTTCAGTTCAGCACTTACCAGTACCAT
ATGCTGCATTCCCACCCCTTATTTCTAGTGATCCATTTCTTATACATCCTCCTCACCTTTCTCCCCATCATCCTCCTCATTTGCCACCAC
CAGGCCAGTTTGTCCCTTTCCAAACACAGCAATCACGATCGCCTCTGCAAAGGATAGAAAATGAAGTGGAACTCTTAGGAGAACATCTTC
CAGTAGGAGGTTTTACTTACCCTCCATCAGCCCACCCCCCAACATTACCTCCATCAGCTCCCTTGCAGTTCTTAACACATGATCCTTTGC
ATCAGGAGGTGTCCTTTGGAGTACCTTATCCTCCATTTATGCCTCGGAGGCTTACAGGACGTAGTAGATACCGATCCCAGCAGCCAATAC
CACCTCCCCCTTATCATCCCAGCTTACTGCCATATGTGTTATCAATGCTTCCAGTGCCACCTGCAGTGGGCCCAACTTTCAGCTTTGAAT
TAGATGTAGAAGATGGAGAAGTAGAAAATTACGAGGCCCTGTTAAACCTGGCAGAGCGACTGGGAGAGGCAAAGCCTCGTGGACTGACTA
AAGCAGATATTGAACAACTTCCTTCTTATCGGTTCAATCCTAACAACCACCAGTCAGAACAGACTTTGTGTGTAGTATGCATGTGTGATT
TTGAGTCAAGGCAGCTACTTAGAGTCTTACCCTGTAACCACGAGTTCCATGCCAAGTGTGTTGACAAATGGCTTAAGGCAAATCGTACTT
GCCCAATTTGCCGAGCTGATGCTTCAGAAGTGCATCGGGATTCAGAATGACCAACCTAAGAAGCACAAATTTAGTTTGGGTGTTCCTCAT
CACATGTATATACGGACTATCCATTGAACTTAATCTGTGTGGCTTCCAGCCCTCCCTTTACCAAAAGGGTCAATGGACCTTTCTTTGCAC
TGTGTGACTTAATCAACTATAAAAGCTTACAATTAGTCTTCACAGTTATGGGATTGTTATACTAACCGTGTGATTGGAACTCCAAAGACT
TTTTCTTTAGCTTAATTTTGTGTGTGCACTAACATTCCCTGGTTTTTGTGTGATCATTCCGAGTGTTGCTGCAAGATTACAGTGGACGTG
ATCTTTTAGCATGTGCTTTTATAAAAAGTGGTAGCTACAGATGATATAGCAATCTACCTTATATAGAGCCTTCAGAAACTGTGAGTGGAA
ATGAATGCGCAGCGTATGACTGTTGGTGATAAGTGTATCTGTGTGAGTGTGTGCAACTACTTGTGTGAGGGCATGGTAGCTAACGTGTGT
ATGAGATCCTATATACCAGCATGTACCAAGAATGTGTGTGTAGTTTTAATTATGCTGCAATGTATAATCTGGTGTGTTATTTAAACAGCA
CTAGTACTGTACACTGGTTTTTTTCCCTTGTGTTTGCTGTTGCACACTGATTGCTGAGGGTGCATCAATTACAAGCATTGAATACTCCAT
CCCCTTCCCTCCCAGTGAATGGAATGAGAAAAGCCTTCTTCCTTTGCTTCAGGCAGCTGTCACCTTCTCTTTATTGGTGGTCCTAAGTGG
GTCACTTAAGAAAAAAAAGTGTAACAAATTCTCGCTCCATGAACCTGGTTTTTTTTTATTCTGTTGTGGAAATTTTTAAATCTCCAACTT
GCTGTTTCCAAAAAGAAGGTGCAATATCATATATCATCAGTTAGCAATATTAGCATTTCAATCAGTGATTTGAATGTTGATACTTTTTTT
TCCTTTACATTTCCAGTAAGTTTCTTACAGAAAGTACCTGTGATTTTTTTTAATGTTTAGATTTGTAGTCTAGTCTATTCTGAAGATATT
TGATTAATATATTTCTAAGAAGACCACTAGTCCCATGAAGTCTCACCTTGTTGACTTCCACCAGAACAAAACCTGTTAATTCAGCTTGAC
TTCTCATATGTGTTCTGTGTTCAAGCTCCTGTGGGCAACTCAATTGTTTTAAGAAAACTCTATTTCTGTTCATATTAATTCACTTGCCAG
ACTCCAATTCTGAAAGTTGTCTAGTTCTTCCTTCATCACACGTGCTTCTCATCGAAACCCTGGTTTCAGGATGGATCAAGTGCTGTTACA
GCTCATGTTCCTTAGACCTGATTTGTTTTGATATTTTACTGCCTTTCCTTTTAATTTTTGTTTGAATGAGAAAAGTTTAATACAACAGGT
GTCCAGAATACTTGCAGTATAAATGAAGATTTGGTTTTTGTATAAAAAAATAATGCTGTTAAACAGGAGTTGACCTTCATTTAGTTGATG
TAATACATAGCTGTATGGGGTTTTTTTTAGTAAGTTCTTTGAGCATAATTCACTTTAAAGTCATTTTTCCAGCAATGTTTAAATTACTTT
CTCATTCTTTTAGTGTATTCAACATTGTCTGCCTCTTCCTGCAGTTGATGTAATTGCTTTGTTTGCAATAGCACAAGCTGCATTATTCCA
GTCAGGACTGTGATAACTTGCTGCCAGCCCCACTCAACTTTCAGTTGGCTCTGTGTCAGTTTTCCATTCAGTGTTAACTACTTGTTACTG
CCATGCTGCTTGCCCTCCCTTGAAGTGTCTATAAGCTCATCACAGCCTAGAGTTAAGTAAAGTCAATTCACAGAAGCACAATTTTGCCCT
TTGCGAGACATTGTTGCCTCTATCTAGTCCTACAAGTAGGGTTTTGCATACTGTGTTTGCCCCTAGGGTTGTCAGTGCATCAGAAATACT
TCTAAATAGTGGTAAAAATGCACATGGTTAATGCACATGTTACTTTTAAATCATTAGGATATCCCTCACCTGTTCCTGATGAATAAAAAG
TGTGTTAAAGACCAAAATTCTTGGCATAATAATCAGCTACATACAAATCACATATAGTTTAATCTTTTTTAATGAAAAAAAATCATGTTT
AAAATGGCAAAAGCCCATCTTATACACTTTTATATAGCTGCAAAAAATTTATATCTGTACAGATCTAACACTACGACACTCAGTATTCAT
TTTATTGAAGCATGCAAGTAAAGCACTTTTTCTAATTTATATAGAGGTATCTAATTAACACAGCACATTGTACTAATGACTAGGAGTAGC
AGCTTTTTCTTCTCTCCCTCTATGAATTCTTATAATGTCCCTTTTTCTGTAAGTTTTTGAGAGGCAATTGGCAATTTAGGAGGCAGCAGG
GTCTGTTTTGGTCAAATCTTGAATTTCGTTGTTGCACTCTAGTGACTGATCTTTGGGAATGTCTTGTCTTTGCATGGGGCTCATAGAGAT
GTGTGCAGACTTGCTTATTGTGGTTAGTGTGTATCAGGAACACACACACAGGTGTTCTGACCAGCTCAGGCTTGCCACAGTGAGCAACTC
TGTGGCTAGCAAAAGAGAAGTTTATTTGTGCCCAGCCATTGGTCACCTTGGGTGATGCACCAGATAGCAGGCAGATGTTGGTTCATTGGC
CTTCGTCCTCTTTCCTCCTAAAATAATATTGGCTTTACCATCTTAACTCAGCTGTGGGTTTTTTGTGGGTTCTTGTTTGTTTTTTGGCAT
GAATTGTCATCTTTGGTGTTTTTTTAACCCCCAGCCCCTCAAAAAAATAAGGCCTCCAGGTATCAAGATCTCATATTAGGATTTTCTGTC
CTTAATTTTTTGAGCAAAATCTGGAAAATGTGAAAGCATATTTAGATTTTATATACTATCTGAAATGTGATTTGTTAAGATTCTTAAATT
TGGGCCTCTTAGAATAATTTTGAATGAGATCTACCGACTCACTTGTGAGAATATTTTTCACAGATTATCTTTGGGCCTTTTCATTAGAAA
GCTGTTTGTTTGTCCCCCTGTTGGTACATTTGGTTACCTCATTTTGCCGTTTCAGATTGTGAAAGCTCACAGGGGTGTTTTTTGGAATCA
TTTGCTGAGTCATTTTCTCAAATCATATTCCATTGTATCAGTTAACATATAGTTTTAAATGTATGTATTATAAATATCTGTAACCAAATC
ATTTGAAGGCTTGATAAATTTTTAACAAAGTTTGTACATTTTTTATGAAAGTTACTAGTAATGCTTTACTAAGTAGTGCAATGAATTTTT

>75316_75316_3_ROCK1-RNF38_ROCK1_chr18_18690779_ENST00000399799_RNF38_chr9_36390613_ENST00000259605_length(amino acids)=556AA_BP=45
MLVLVRGHCHSSSNMSTGDSFETRFEKMDNLLRDPKSEVNSDCLLISPGANSASLPGHPNKVICERVRLQSLFPLLPSDQNTTVQEDAHF
KAFFQSEDSPSPKRQRLSHSVFDYTSASPAPSPPMRPWEMTSNRQPPSVRPSQHHFSGERCNTPARNRRSPPVRRQRGRRDRLSRHNSIS
QDENYHHLPYAQQQAIEEPRAFHPPNVSPRLLHPAAHPPQQNAVMVDIHDQLHQGTVPVSYTVTTVAPHGIPLCTGQHIPACSTQQVPGC
SVVFSGQHLPVCSVPPPMLQACSVQHLPVPYAAFPPLISSDPFLIHPPHLSPHHPPHLPPPGQFVPFQTQQSRSPLQRIENEVELLGEHL
PVGGFTYPPSAHPPTLPPSAPLQFLTHDPLHQEVSFGVPYPPFMPRRLTGRSRYRSQQPIPPPPYHPSLLPYVLSMLPVPPAVGPTFSFE
LDVEDGEVENYEALLNLAERLGEAKPRGLTKADIEQLPSYRFNPNNHQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVDKWLKANRT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ROCK1-RNF38

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	ROCK1	chr18:18690779	chr9:36376124	ENST00000399799	-	1	33	368_727	31.0	1355.0	FHOD1
Hgene	ROCK1	chr18:18690779	chr9:36390613	ENST00000399799	-	1	33	368_727	31.0	1355.0	FHOD1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ROCK1-RNF38

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ROCK1-RNF38

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source