FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ROCK2-ASAP2 (FusionGDB2 ID:75319)

Fusion Gene Summary for ROCK2-ASAP2

check button Fusion gene summary
Fusion gene informationFusion gene name: ROCK2-ASAP2
Fusion gene ID: 75319
HgeneTgene
Gene symbol

ROCK2

ASAP2

Gene ID

9475

8853

Gene nameRho associated coiled-coil containing protein kinase 2ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
SynonymsROCK-IIAMAP2|CENTB3|DDEF2|PAG3|PAP|Pap-alpha|SHAG1
Cytomap

2p25.1

2p25.1|2p24

Type of geneprotein-codingprotein-coding
Descriptionrho-associated protein kinase 2p164 ROCK-2rho-associated, coiled-coil-containing protein kinase IIarf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2PYK2 C terminus-associated proteincentaurin, beta 3development and differentiation-enhancing factor 2paxillin-associated protein with ARF GAP activity 3pyk2 C-terminus-associated p
Modification date2020032920200327
UniProtAcc.

O43150

Ensembl transtripts involved in fusion geneENST00000315872, ENST00000401753, 
ENST00000462366, 		ENST00000491413, 
ENST00000281419, ENST00000315273, 
Fusion gene scores* DoF score16 X 11 X 9=15849 X 10 X 4=360
# samples 1711
** MAII scorelog2(17/1584*10)=-3.21996568394191
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ROCK2 [Title/Abstract] AND ASAP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointROCK2(11338617)-ASAP2(9419446), # samples:3
Anticipated loss of major functional domain due to fusion event.ROCK2-ASAP2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ROCK2-ASAP2 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
ROCK2-ASAP2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneROCK2

GO:0006468

protein phosphorylation

18559669


check buttonFusion gene breakpoints across ROCK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ASAP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GU-01AROCK2chr2

11338617

-ASAP2chr2

9419446

+


Top

Fusion Gene ORF analysis for ROCK2-ASAP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000315872ENST00000491413ROCK2chr2

11338617

-ASAP2chr2

9419446

+
5CDS-intronENST00000401753ENST00000491413ROCK2chr2

11338617

-ASAP2chr2

9419446

+
Frame-shiftENST00000401753ENST00000281419ROCK2chr2

11338617

-ASAP2chr2

9419446

+
Frame-shiftENST00000401753ENST00000315273ROCK2chr2

11338617

-ASAP2chr2

9419446

+
In-frameENST00000315872ENST00000281419ROCK2chr2

11338617

-ASAP2chr2

9419446

+
In-frameENST00000315872ENST00000315273ROCK2chr2

11338617

-ASAP2chr2

9419446

+
intron-3CDSENST00000462366ENST00000281419ROCK2chr2

11338617

-ASAP2chr2

9419446

+
intron-3CDSENST00000462366ENST00000315273ROCK2chr2

11338617

-ASAP2chr2

9419446

+
intron-intronENST00000462366ENST00000491413ROCK2chr2

11338617

-ASAP2chr2

9419446

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000315872ROCK2chr211338617-ENST00000281419ASAP2chr29419446+8794354844964421997
ENST00000315872ROCK2chr211338617-ENST00000315273ASAP2chr29419446+8664354844963071952

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000315872ENST00000281419ROCK2chr211338617-ASAP2chr29419446+0.0011114460.99888855
ENST00000315872ENST00000315273ROCK2chr211338617-ASAP2chr29419446+0.0008020990.9991979

Top

Fusion Genomic Features for ROCK2-ASAP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ROCK2chr211338616-ASAP2chr29419445+0.0001614640.9998385
ROCK2chr211338616-ASAP2chr29419445+0.0001614640.9998385

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for ROCK2-ASAP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:11338617/chr2:9419446)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ASAP2

O43150

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:10749932, ECO:0000269|PubMed:11304556}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneROCK2chr2:11338617chr2:9419446ENST00000315872-2533429_102410331389.0Coiled coilOntology_term=ECO:0000255
HgeneROCK2chr2:11338617chr2:9419446ENST00000315872-2533357_42510331389.0DomainAGC-kinase C-terminal
HgeneROCK2chr2:11338617chr2:9419446ENST00000315872-2533497_57310331389.0DomainREM-1
HgeneROCK2chr2:11338617chr2:9419446ENST00000315872-253392_35410331389.0DomainProtein kinase
HgeneROCK2chr2:11338617chr2:9419446ENST00000315872-253398_10610331389.0Nucleotide bindingATP
TgeneASAP2chr2:11338617chr2:9419446ENST00000281419028256_283421007.0Coiled coilOntology_term=ECO:0000255
TgeneASAP2chr2:11338617chr2:9419446ENST00000281419028729_752421007.0Coiled coilOntology_term=ECO:0000255
TgeneASAP2chr2:11338617chr2:9419446ENST00000315273027256_28342962.0Coiled coilOntology_term=ECO:0000255
TgeneASAP2chr2:11338617chr2:9419446ENST00000315273027729_75242962.0Coiled coilOntology_term=ECO:0000255
TgeneASAP2chr2:11338617chr2:9419446ENST00000281419028771_936421007.0Compositional biasNote=Pro-rich
TgeneASAP2chr2:11338617chr2:9419446ENST00000315273027771_93642962.0Compositional biasNote=Pro-rich
TgeneASAP2chr2:11338617chr2:9419446ENST00000281419028305_397421007.0DomainPH
TgeneASAP2chr2:11338617chr2:9419446ENST00000281419028421_543421007.0DomainArf-GAP
TgeneASAP2chr2:11338617chr2:9419446ENST00000281419028944_1006421007.0DomainSH3
TgeneASAP2chr2:11338617chr2:9419446ENST00000315273027305_39742962.0DomainPH
TgeneASAP2chr2:11338617chr2:9419446ENST00000315273027421_54342962.0DomainArf-GAP
TgeneASAP2chr2:11338617chr2:9419446ENST00000315273027944_100642962.0DomainSH3
TgeneASAP2chr2:11338617chr2:9419446ENST00000281419028584_616421007.0RepeatNote=ANK 1
TgeneASAP2chr2:11338617chr2:9419446ENST00000281419028620_649421007.0RepeatNote=ANK 2
TgeneASAP2chr2:11338617chr2:9419446ENST00000315273027584_61642962.0RepeatNote=ANK 1
TgeneASAP2chr2:11338617chr2:9419446ENST00000315273027620_64942962.0RepeatNote=ANK 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneROCK2chr2:11338617chr2:9419446ENST00000315872-25331053_113110331389.0Coiled coilOntology_term=ECO:0000255
HgeneROCK2chr2:11338617chr2:9419446ENST00000315872-25331150_134910331389.0DomainPH
HgeneROCK2chr2:11338617chr2:9419446ENST00000315872-2533979_104710331389.0RegionRHOA binding
HgeneROCK2chr2:11338617chr2:9419446ENST00000315872-25331260_131510331389.0Zinc fingerPhorbol-ester/DAG-type


Top

Fusion Gene Sequence for ROCK2-ASAP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>75319_75319_1_ROCK2-ASAP2_ROCK2_chr2_11338617_ENST00000315872_ASAP2_chr2_9419446_ENST00000281419_length(transcript)=8794nt_BP=3548nt
CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG
GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC
GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG
GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG
CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA
TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG
AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGGATGGCTTAAATTCCTTGGTCCTTGATTTAGATTTTCCTG
CTTTGAGGAAAAACAAGAACATAGATAATTTCTTAAATAGATATGAGAAAATTGTGAAAAAAATCAGAGGTCTACAGATGAAGGCAGAAG
ACTATGATGTTGTAAAAGTTATTGGAAGAGGTGCTTTTGGTGAAGTGCAGTTGGTTCGTCACAAGGCATCGCAGAAGGTTTATGCTATGA
AGCTTCTTAGTAAGTTTGAAATGATAAAAAGATCAGATTCTGCCTTTTTTTGGGAAGAAAGAGATATTATGGCCTTTGCCAATAGCCCCT
GGGTGGTTCAGCTTTTTTATGCCTTTCAAGATGATAGGTATCTGTACATGGTAATGGAGTACATGCCTGGTGGAGACCTTGTAAACCTTA
TGAGTAATTATGATGTGCCTGAAAAATGGGCCAAATTTTACACTGCTGAAGTTGTTCTTGCTCTGGATGCAATACACTCCATGGGTTTAA
TACACAGAGATGTGAAGCCTGACAACATGCTCTTGGATAAACATGGACATCTAAAATTAGCAGATTTTGGCACGTGTATGAAGATGGATG
AAACAGGCATGGTACATTGTGATACAGCAGTTGGAACACCGGATTATATATCACCTGAGGTTCTGAAATCACAAGGGGGTGATGGTTTCT
ATGGGCGAGAATGTGATTGGTGGTCTGTAGGTGTTTTCCTTTATGAGATGCTAGTGGGGGATACTCCATTTTATGCGGATTCACTTGTAG
GAACATATAGCAAAATTATGGATCATAAGAATTCACTGTGTTTCCCTGAAGATGCAGAAATTTCCAAACATGCAAAGAATCTCATCTGTG
CTTTCTTAACAGATAGGGAGGTACGACTTGGGAGAAATGGGGTGGAAGAAATCAGACAGCATCCTTTCTTTAAGAATGATCAGTGGCATT
GGGATAACATAAGAGAAACGGCAGCTCCTGTAGTACCTGAACTCAGCAGTGACATAGACAGCAGCAATTTCGATGACATTGAAGATGACA
AAGGAGATGTAGAAACCTTCCCAATTCCTAAAGCTTTTGTTGGAAATCAGCTGCCTTTCATCGGATTTACCTACTATAGAGAAAATTTAT
TATTAAGTGACTCTCCATCTTGTAGAGAAACTGATTCCATACAATCAAGGAAAAATGAAGAAAGTCAAGAGATTCAGAAAAAACTGTATA
CATTAGAAGAACATCTTAGCAATGAGATGCAAGCCAAAGAGGAACTGGAACAGAAGTGCAAATCTGTTAATACTCGCCTAGAAAAAACAG
CAAAGGAGCTAGAAGAGGAGATTACCTTACGGAAAAGTGTGGAATCAGCATTAAGACAGTTAGAAAGAGAAAAGGCGCTTCTTCAGCACA
AAAATGCAGAATATCAGAGGAAAGCTGATCATGAAGCAGACAAAAAACGAAATTTGGAAAATGATGTTAACAGCTTAAAAGATCAACTTG
AAGATTTGAAAAAAAGAAATCAAAACTCTCAAATATCCACTGAGAAAGTGAATCAACTCCAGAGACAACTGGATGAAACCAATGCTTTAC
TGCGAACAGAGTCTGATACTGCAGCCCGGTTAAGGAAAACCCAGGCAGAAAGTTCAAAACAGATTCAGCAGCTGGAATCTAACAATAGAG
ATCTACAAGATAAAAACTGCCTGCTGGAGACTGCCAAGTTAAAACTTGAAAAGGAATTTATCAATCTTCAGTCAGCTCTAGAATCTGAAA
GGAGGGATCGAACCCATGGATCAGAGATAATTAATGATTTACAAGGTAGAATATGTGGCCTAGAAGAAGATTTAAAGAACGGCAAAATCT
TACTAGCGAAAGTAGAACTGGAGAAGAGACAACTTCAGGAGAGATTTACTGATTTGGAAAAGGAAAAAAGCAACATGGAAATAGATATGA
CATACCAACTAAAAGTTATACAGCAGAGCCTAGAACAAGAAGAAGCTGAACATAAGGCCACAAAGGCACGACTAGCAGATAAAAATAAGA
TCTATGAGTCCATCGAAGAAGCCAAATCAGAAGCCATGAAAGAAATGGAGAAGAAGCTCTTGGAGGAAAGAACTTTAAAACAGAAAGTGG
AGAACCTATTGCTAGAAGCTGAGAAAAGATGTTCTCTATTAGACTGTGACCTCAAACAGTCACAGCAGAAAATAAATGAGCTCCTTAAAC
AGAAAGATGTGCTAAATGAGGATGTTAGAAACCTGACATTAAAAATAGAGCAAGAAACTCAGAAGCGCTGCCTTACACAAAATGACCTGA
AGATGCAAACACAACAGGTTAACACACTAAAAATGTCAGAAAAGCAGTTAAAGCAAGAAAATAACCATCTCATGGAAATGAAAATGAACT
TGGAAAAACAAAATGCTGAACTTCGAAAAGAACGTCAGGATGCAGATGGGCAAATGAAAGAGCTCCAGGATCAGCTCGAAGCAGAACAGT
ATTTCTCAACCCTTTATAAAACACAAGTTAGGGAGCTTAAAGAAGAATGTGAAGAAAAGACCAAACTTGGTAAAGAATTGCAGCAGAAGA
AACAGGAATTACAGGATGAACGGGACTCTTTGGCTGCCCAACTGGAGATCACCTTGACCAAAGCAGATTCTGAGCAACTGGCTCGTTCAA
TTGCTGAAGAACAATATTCTGATTTGGAAAAAGAGAAGATCATGAAAGAGCTGGAGATCAAAGAGATGATGGCTAGACACAAACAGGAAC
TTACGGAAAAAGATGCTACAATTGCTTCTCTTGAGGAAACTAATAGGACACTAACTAGTGATGTTGCCAATCTTGCAAATGAGAAAGAAG
AATTAAATAACAAATTGAAAGATGTTCAAGAGCAACTGTCAAGATTGAAAGATGAAGAAATAAGCGCAGCAGCTATTAAAGCACAGTTTG
AGAAGCAGCTATTAACAGAAAGAACACTCAAAACTCAAGCTTTGGACGTGGACCGGATGGTTCTTTACAAAATGAAGAAATCCGTGAAAG
CAATCAACAGCTCTGGGCTGGCTCACGTGGAAAATGAAGAGCAGTACACCCAGGCTCTGGAGAAGTTTGGCGGCAACTGTGTATGCAGAG
ATGACCCAGATTTAGGAAGTGCGTTCCTGAAGTTCTCAGTGTTTACAAAGGAGTTGACAGCACTTTTCAAAAACCTGATTCAGAATATGA
ACAACATAATCTCCTTCCCTTTGGACAGTTTGCTGAAGGGGGACCTGAAAGGAGTGAAAGGGGATCTGAAAAAGCCTTTTGATAAAGCTT
GGAAGGACTATGAAACAAAAATAACCAAGATAGAAAAGGAGAAAAAGGAACACGCCAAGCTCCATGGGATGATTCGGACTGAAATAAGCG
GAGCGGAAATTGCCGAAGAGATGGAAAAGGAGAGGCGCTTCTTCCAGCTACAGATGTGCGAGTATCTGCTGAAGGTCAACGAAATCAAGA
TTAAAAAGGGAGTAGATTTACTTCAGAATCTGATCAAATACTTTCATGCCCAATGCAATTTTTTTCAGGATGGACTCAAAGCCGTGGAAA
GCCTCAAACCTTCCATTGAAACGCTGTCTACGGATCTTCACACGATCAAACAGGCCCAGGATGAAGAAAGAAGGCAGTTGATACAGCTTC
GAGATATTTTGAAATCCGCATTGCAGGTTGAACAGAAAGAGGACTCCCAAATTCGTCAGAGCACAGCTTATAGCTTACATCAGCCTCAGG
GAAACAAGGAACATGGGACCGAGCGGAACGGCAGCCTCTACAAGAAGAGTGACGGGATCCGAAAAGTGTGGCAGAAAAGGAAATGTTCAG
TTAAAAATGGTTTTCTGACCATATCCCATGGTACCGCTAACCGGCCTCCTGCAAAGCTCAACCTGCTAACCTGCCAGGTGAAGACCAACC
CTGAGGAGAAGAAGTGCTTTGACCTCATTTCACATGACAGAACTTACCACTTTCAAGCTGAAGATGAACAGGAATGTCAAATATGGATGT
CTGTGCTGCAAAATAGCAAAGAAGAAGCTTTAAACAATGCATTTAAGGGGGATGACAATACTGGAGAAAATAACATCGTCCAAGAACTGA
CAAAGGAGATCATCTCAGAAGTGCAGAGGATGACGGGCAATGACGTCTGCTGTGACTGTGGGGCGCCAGATCCTACATGGCTTTCCACCA
ACCTGGGCATCCTGACCTGCATCGAGTGTTCCGGAATCCACCGAGAGCTGGGGGTTCATTATTCCAGGATGCAGTCCCTGACCTTAGATG
TACTGGGAACATCTGAGCTGCTGCTCGCCAAGAATATTGGGAATGCAGGCTTTAATGAGATCATGGAATGTTGCCTACCAGCTGAGGACT
CAGTCAAACCCAACCCAGGCAGCGACATGAATGCAAGAAAGGACTACATCACAGCCAAGTACATCGAGAGGAGATACGCAAGGAAGAAGC
ACGCGGATAACGCGGCGAAGCTTCACAGTCTTTGCGAGGCCGTCAAAACGAGAGATATTTTTGGATTGCTCCAAGCTTATGCTGATGGTG
TGGATCTTACGGAAAAAATCCCACTGGCCAACGGACATGAGCCGGATGAAACGGCCCTCCACCTTGCAGTCAGATCCGTGGATCGAACCT
CTCTTCACATTGTAGACTTTTTAGTTCAGAACAGTGGGAACCTGGATAAACAGACAGGGAAAGGCAGCACAGCCCTGCACTACTGCTGCC
TGACCGACAATGCCGAGTGCCTCAAGTTGCTCCTGCGGGGGAAGGCCTCCATCGAGATAGCAAACGAGTCAGGAGAGACTCCGCTGGACA
TTGCCAAGCGCCTCAAGCACGAGCACTGTGAGGAGCTGCTGACCCAAGCCTTATCTGGAAGATTTAATTCTCACGTTCACGTTGAATATG
AATGGCGACTACTCCACGAAGACCTGGATGAAAGTGATGACGACATGGATGAGAAATTGCAGCCCAGTCCCAACCGGCGGGAAGACCGGC
CCATCAGCTTCTACCAGCTGGGCTCCAACCAGCTTCAGTCTAACGCTGTATCTTTGGCCAGAGATGCTGCAAACCTTGCCAAGGAGAAGC
AGAGGGCTTTCATGCCCAGCATCTTGCAGAATGAGACTTACGGAGCCCTCCTGAGTGGCAGCCCACCTCCCGCCCAGCCTGCAGCCCCCA
GCACCACCAGCGCCCCCCCGCTTCCTCCACGGAATGTTGGCAAAGTTCAGACAGCCTCCTCTGCTAACACCCTGTGGAAGACAAACTCTG
TAAGTGTGGACGGTGGAAGCCGGCAGCGATCTTCGTCAGATCCGCCAGCTGTCCATCCACCGCTGCCCCCTCTTCGCGTGACATCTACCA
ATCCCCTGACCCCCACGCCGCCCCCACCCGTTGCCAAGACGCCCAGCGTAATGGAAGCCTTGAGCCAGCCGAGCAAGCCTGCCCCGCCTG
GGATCTCACAGATCAGGCCCCCACCTCTGCCCCCACAGCCGCCCAGCCGCCTCCCGCAGAAGAAGCCTGCGCCGGGGGCTGACAAGTCCA
CCCCACTGACCAACAAAGGCCAACCGAGAGGACCTGTGGATCTCTCTGCAACGGAAGCTCTGGGTCCTCTGTCCAATGCTATGGTCCTGC
AGCCCCCTGCACCCATGCCTAGGAAGTCGCAGGCAACCAAGTTGAAGCCTAAGCGGGTGAAAGCGCTCTATAACTGTGTGGCTGACAACC
CCGATGAGCTCACCTTCTCCGAGGGGGATGTGATCATCGTGGACGGGGAGGAGGACCAGGAGTGGTGGATTGGCCACATTGATGGAGATC
CTGGTCGCAAAGGCGCATTCCCGGTGTCATTTGTGCACTTTATCGCTGACTGAATTGCTACTGAACAAAAGCATTAACAGTTATGTTCCT
GTTTCGTTATTGGTACCAAAACTCTTGCCAGATAACCAGTTTCATGAACTGTTTGTATGGCAGCCCATGTTCTCTAATGCCACTGCTCTG
TTTTAAAAACTCAGAGGCAATTTTTACATATCAGTAATTGTTTTTATAATTTGTGGTTTTCATGAAACATTGCTATGCATTTATTAGGAA
AAACTGAATTTCCCAACAGGTGAACTGAAAAGTTATTTTAACTATTATACATAATCAAGATCCTGCCTCTACGGAATTAGCTAAACCTAA
AAATGTTTGCATTAATGAATAAATTCTTCCTGCATTCCTTGGCCCAGTTCTGGAGTTGGTGACCTTTATCACAATTATTATTTTAGGCGG
CCAGTGAACTGCTGCTTCAGAAGTCCATAGCCCAGCTCTGAACTTTCTCGATAAAATGCCATCAGTTCACCTTTAAAGACACACATTCCT
TTGAAATCCACCCAGTGTTTAAAAAGCAACTTGGAAATTTACACATTAGCATTGTACTTTCTAGCCCTAATTTGTGAGGTTGCAGCTATC
ATTATATTCTGCATGTATGTATAACCTGTTGTGAACAATCATACTTAACAAAACTACTGATGGTTTATGACAACGTAGGGTAACTACAGT
TCATTCTGTTCCAGGTTATATAAAACTGCATTTCCTGAATTTGGTTAAAAACTAAGGATGATGGATTGCAAAACAGTTCTTTTAAATTAG
TTTATATGCTTTAGGTGTTTTGGAATTTGCCTTCTTGAACTTCCTGAGTCACACAGAAAGCAACTGTACACAGTAGAATTCTGTGGCGCA
GACCATGCTGTATTAACACATCACTTGCTGTTTCCTACTGAGTGTACCACTGCCTTCCCTTCTAGCCCAGGAGAATGTTTACTCAGTTTA
GTGTCTTGTATTTCTATAATACTCCAACAGGAATGGTAGTCACACTGTCTTGAAATTGAATCTGTCCATCTGTTTATAATCAAGAACATA
TCAGAAATATATAGGTCCCAGGTAATACTCCCAAACATCCCACTTTTTACTGTTTCAGGCCATCATATCATTCTTAAGCTACTTGGGGTG
GTAGTAGAGGATTAGGTTGTCTATTATAAAACCAAAACTCATTCGTTTAATGAACTTGACTGTCATACCTCTATTTAGTAATTGCGAGGG
TAAGATTCATAGTAGGAATATTGGAAATTTTGGCACTCTGAGAATAAATAGGCATATGATACCCACTTGGACTTTTAACAAAAGTAAAGG
AATAAATTTGCATATAGGCTTGGAAAGTGAGGCAGCAATGCTGTTAACTGCATTTGTTGTGATGGTGCATTTGATTGAAGCAGCTTGTCT
TTATTATGCAAGACTGTGTAGAGTTTTTTTTTTTTTTGGCATTGTACTTTTTGTTTTTGTTATAAAGGAAGACAGAACAAACTGGAATGT
TTTATGATGTTGTATAGCAATCGCTTTTTACCTTTCAAAGTTCCGGGTAAAAATGTGTTATATCTGTAGTTTTTTGTTTTTGTTTTTTTT
TAAAGCACTACATCTGTTTTCACTAATTGTTAATTTCTGTTTGAACCCTTCATTTAATTTTCTCATAGATTTAAGTAAACAGATGTATTT
TGCACAGTGCACTTATGTCTATTTTAACAATCCTCCTGCATCTGTATTTTATAGTCAGCCTTTTGACCACCTGGTGCCAGCTATATAAGG
AATAAAGTTGATTCATATCAACATTAGAACTCCAGTCCCAAACTAATCTGTCAGGTTCACTGGTACATAAATACCTAGGAAATATTTTTC
CAGTCTACAATTTGGTGCTATTGTGCAGTAACTAATAGTACTCTTACCAGAGGAGAAATTATATTAACGACCCTGCTAATATCCTTTCTT
AGTTATTTGCTCCTTGCAAATTAAAAAAGCAACTAAGAGAAAGAAAAACATTGTAGATATCTATTTATATTTAAAGTTTATGTTTCATGA
ACTGCAGCTGCAGGATTCTGGCATTTTGCATGCCATTCTCCATCAGATCTGGGATGATGGCTCAGAACATGTACACAGACTAAGAGTAAC
TGTGTGATCTGTTAAGGGGTGGATAACATAATATGCAGCTTAGGATGCTATTTTGAGATGTATGATATTCAGTTCATTCACCTGATTACT
TTGGTTGCAGCACAACTGTATATATTGTATAACCGAAATTGATTATTTTCATTGTCCTTAATGCAGTGATTTATAATTAGAGCATGTTTA

>75319_75319_1_ROCK2-ASAP2_ROCK2_chr2_11338617_ENST00000315872_ASAP2_chr2_9419446_ENST00000281419_length(amino acids)=1997AA_BP=1033
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAE
DYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNL
MSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGF
YGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWH
WDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLY
TLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQL
EDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESE
RRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNK
IYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDL
KMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQK
KQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKE
ELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCR
DDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDYETKITKIEKEKKEHAKLHGMIRTEIS
GAEIAEEMEKERRFFQLQMCEYLLKVNEIKIKKGVDLLQNLIKYFHAQCNFFQDGLKAVESLKPSIETLSTDLHTIKQAQDEERRQLIQL
RDILKSALQVEQKEDSQIRQSTAYSLHQPQGNKEHGTERNGSLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVKTN
PEEKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKEIISEVQRMTGNDVCCDCGAPDPTWLST
NLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKK
HADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFLVQNSGNLDKQTGKGSTALHYCC
LTDNAECLKLLLRGKASIEIANESGETPLDIAKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDMDEKLQPSPNRREDR
PISFYQLGSNQLQSNAVSLARDAANLAKEKQRAFMPSILQNETYGALLSGSPPPAQPAAPSTTSAPPLPPRNVGKVQTASSANTLWKTNS
VSVDGGSRQRSSSDPPAVHPPLPPLRVTSTNPLTPTPPPPVAKTPSVMEALSQPSKPAPPGISQIRPPPLPPQPPSRLPQKKPAPGADKS
TPLTNKGQPRGPVDLSATEALGPLSNAMVLQPPAPMPRKSQATKLKPKRVKALYNCVADNPDELTFSEGDVIIVDGEEDQEWWIGHIDGD

--------------------------------------------------------------
>75319_75319_2_ROCK2-ASAP2_ROCK2_chr2_11338617_ENST00000315872_ASAP2_chr2_9419446_ENST00000315273_length(transcript)=8664nt_BP=3548nt
CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG
GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC
GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG
GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG
CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA
TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG
AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGGATGGCTTAAATTCCTTGGTCCTTGATTTAGATTTTCCTG
CTTTGAGGAAAAACAAGAACATAGATAATTTCTTAAATAGATATGAGAAAATTGTGAAAAAAATCAGAGGTCTACAGATGAAGGCAGAAG
ACTATGATGTTGTAAAAGTTATTGGAAGAGGTGCTTTTGGTGAAGTGCAGTTGGTTCGTCACAAGGCATCGCAGAAGGTTTATGCTATGA
AGCTTCTTAGTAAGTTTGAAATGATAAAAAGATCAGATTCTGCCTTTTTTTGGGAAGAAAGAGATATTATGGCCTTTGCCAATAGCCCCT
GGGTGGTTCAGCTTTTTTATGCCTTTCAAGATGATAGGTATCTGTACATGGTAATGGAGTACATGCCTGGTGGAGACCTTGTAAACCTTA
TGAGTAATTATGATGTGCCTGAAAAATGGGCCAAATTTTACACTGCTGAAGTTGTTCTTGCTCTGGATGCAATACACTCCATGGGTTTAA
TACACAGAGATGTGAAGCCTGACAACATGCTCTTGGATAAACATGGACATCTAAAATTAGCAGATTTTGGCACGTGTATGAAGATGGATG
AAACAGGCATGGTACATTGTGATACAGCAGTTGGAACACCGGATTATATATCACCTGAGGTTCTGAAATCACAAGGGGGTGATGGTTTCT
ATGGGCGAGAATGTGATTGGTGGTCTGTAGGTGTTTTCCTTTATGAGATGCTAGTGGGGGATACTCCATTTTATGCGGATTCACTTGTAG
GAACATATAGCAAAATTATGGATCATAAGAATTCACTGTGTTTCCCTGAAGATGCAGAAATTTCCAAACATGCAAAGAATCTCATCTGTG
CTTTCTTAACAGATAGGGAGGTACGACTTGGGAGAAATGGGGTGGAAGAAATCAGACAGCATCCTTTCTTTAAGAATGATCAGTGGCATT
GGGATAACATAAGAGAAACGGCAGCTCCTGTAGTACCTGAACTCAGCAGTGACATAGACAGCAGCAATTTCGATGACATTGAAGATGACA
AAGGAGATGTAGAAACCTTCCCAATTCCTAAAGCTTTTGTTGGAAATCAGCTGCCTTTCATCGGATTTACCTACTATAGAGAAAATTTAT
TATTAAGTGACTCTCCATCTTGTAGAGAAACTGATTCCATACAATCAAGGAAAAATGAAGAAAGTCAAGAGATTCAGAAAAAACTGTATA
CATTAGAAGAACATCTTAGCAATGAGATGCAAGCCAAAGAGGAACTGGAACAGAAGTGCAAATCTGTTAATACTCGCCTAGAAAAAACAG
CAAAGGAGCTAGAAGAGGAGATTACCTTACGGAAAAGTGTGGAATCAGCATTAAGACAGTTAGAAAGAGAAAAGGCGCTTCTTCAGCACA
AAAATGCAGAATATCAGAGGAAAGCTGATCATGAAGCAGACAAAAAACGAAATTTGGAAAATGATGTTAACAGCTTAAAAGATCAACTTG
AAGATTTGAAAAAAAGAAATCAAAACTCTCAAATATCCACTGAGAAAGTGAATCAACTCCAGAGACAACTGGATGAAACCAATGCTTTAC
TGCGAACAGAGTCTGATACTGCAGCCCGGTTAAGGAAAACCCAGGCAGAAAGTTCAAAACAGATTCAGCAGCTGGAATCTAACAATAGAG
ATCTACAAGATAAAAACTGCCTGCTGGAGACTGCCAAGTTAAAACTTGAAAAGGAATTTATCAATCTTCAGTCAGCTCTAGAATCTGAAA
GGAGGGATCGAACCCATGGATCAGAGATAATTAATGATTTACAAGGTAGAATATGTGGCCTAGAAGAAGATTTAAAGAACGGCAAAATCT
TACTAGCGAAAGTAGAACTGGAGAAGAGACAACTTCAGGAGAGATTTACTGATTTGGAAAAGGAAAAAAGCAACATGGAAATAGATATGA
CATACCAACTAAAAGTTATACAGCAGAGCCTAGAACAAGAAGAAGCTGAACATAAGGCCACAAAGGCACGACTAGCAGATAAAAATAAGA
TCTATGAGTCCATCGAAGAAGCCAAATCAGAAGCCATGAAAGAAATGGAGAAGAAGCTCTTGGAGGAAAGAACTTTAAAACAGAAAGTGG
AGAACCTATTGCTAGAAGCTGAGAAAAGATGTTCTCTATTAGACTGTGACCTCAAACAGTCACAGCAGAAAATAAATGAGCTCCTTAAAC
AGAAAGATGTGCTAAATGAGGATGTTAGAAACCTGACATTAAAAATAGAGCAAGAAACTCAGAAGCGCTGCCTTACACAAAATGACCTGA
AGATGCAAACACAACAGGTTAACACACTAAAAATGTCAGAAAAGCAGTTAAAGCAAGAAAATAACCATCTCATGGAAATGAAAATGAACT
TGGAAAAACAAAATGCTGAACTTCGAAAAGAACGTCAGGATGCAGATGGGCAAATGAAAGAGCTCCAGGATCAGCTCGAAGCAGAACAGT
ATTTCTCAACCCTTTATAAAACACAAGTTAGGGAGCTTAAAGAAGAATGTGAAGAAAAGACCAAACTTGGTAAAGAATTGCAGCAGAAGA
AACAGGAATTACAGGATGAACGGGACTCTTTGGCTGCCCAACTGGAGATCACCTTGACCAAAGCAGATTCTGAGCAACTGGCTCGTTCAA
TTGCTGAAGAACAATATTCTGATTTGGAAAAAGAGAAGATCATGAAAGAGCTGGAGATCAAAGAGATGATGGCTAGACACAAACAGGAAC
TTACGGAAAAAGATGCTACAATTGCTTCTCTTGAGGAAACTAATAGGACACTAACTAGTGATGTTGCCAATCTTGCAAATGAGAAAGAAG
AATTAAATAACAAATTGAAAGATGTTCAAGAGCAACTGTCAAGATTGAAAGATGAAGAAATAAGCGCAGCAGCTATTAAAGCACAGTTTG
AGAAGCAGCTATTAACAGAAAGAACACTCAAAACTCAAGCTTTGGACGTGGACCGGATGGTTCTTTACAAAATGAAGAAATCCGTGAAAG
CAATCAACAGCTCTGGGCTGGCTCACGTGGAAAATGAAGAGCAGTACACCCAGGCTCTGGAGAAGTTTGGCGGCAACTGTGTATGCAGAG
ATGACCCAGATTTAGGAAGTGCGTTCCTGAAGTTCTCAGTGTTTACAAAGGAGTTGACAGCACTTTTCAAAAACCTGATTCAGAATATGA
ACAACATAATCTCCTTCCCTTTGGACAGTTTGCTGAAGGGGGACCTGAAAGGAGTGAAAGGGGATCTGAAAAAGCCTTTTGATAAAGCTT
GGAAGGACTATGAAACAAAAATAACCAAGATAGAAAAGGAGAAAAAGGAACACGCCAAGCTCCATGGGATGATTCGGACTGAAATAAGCG
GAGCGGAAATTGCCGAAGAGATGGAAAAGGAGAGGCGCTTCTTCCAGCTACAGATGTGCGAGTATCTGCTGAAGGTCAACGAAATCAAGA
TTAAAAAGGGAGTAGATTTACTTCAGAATCTGATCAAATACTTTCATGCCCAATGCAATTTTTTTCAGGATGGACTCAAAGCCGTGGAAA
GCCTCAAACCTTCCATTGAAACGCTGTCTACGGATCTTCACACGATCAAACAGGCCCAGGATGAAGAAAGAAGGCAGTTGATACAGCTTC
GAGATATTTTGAAATCCGCATTGCAGGTTGAACAGAAAGAGGACTCCCAAATTCGTCAGAGCACAGCTTATAGCTTACATCAGCCTCAGG
GAAACAAGGAACATGGGACCGAGCGGAACGGCAGCCTCTACAAGAAGAGTGACGGGATCCGAAAAGTGTGGCAGAAAAGGAAATGTTCAG
TTAAAAATGGTTTTCTGACCATATCCCATGGTACCGCTAACCGGCCTCCTGCAAAGCTCAACCTGCTAACCTGCCAGGTGAAGACCAACC
CTGAGGAGAAGAAGTGCTTTGACCTCATTTCACATGACAGAACTTACCACTTTCAAGCTGAAGATGAACAGGAATGTCAAATATGGATGT
CTGTGCTGCAAAATAGCAAAGAAGAAGCTTTAAACAATGCATTTAAGGGGGATGACAATACTGGAGAAAATAACATCGTCCAAGAACTGA
CAAAGGAGATCATCTCAGAAGTGCAGAGGATGACGGGCAATGACGTCTGCTGTGACTGTGGGGCGCCAGATCCTACATGGCTTTCCACCA
ACCTGGGCATCCTGACCTGCATCGAGTGTTCCGGAATCCACCGAGAGCTGGGGGTTCATTATTCCAGGATGCAGTCCCTGACCTTAGATG
TACTGGGAACATCTGAGCTGCTGCTCGCCAAGAATATTGGGAATGCAGGCTTTAATGAGATCATGGAATGTTGCCTACCAGCTGAGGACT
CAGTCAAACCCAACCCAGGCAGCGACATGAATGCAAGAAAGGACTACATCACAGCCAAGTACATCGAGAGGAGATACGCAAGGAAGAAGC
ACGCGGATAACGCGGCGAAGCTTCACAGTCTTTGCGAGGCCGTCAAAACGAGAGATATTTTTGGATTGCTCCAAGCTTATGCTGATGGTG
TGGATCTTACGGAAAAAATCCCACTGGCCAACGGACATGAGCCGGATGAAACGGCCCTCCACCTTGCAGTCAGATCCGTGGATCGAACCT
CTCTTCACATTGTAGACTTTTTAGTTCAGAACAGTGGGAACCTGGATAAACAGACAGGGAAAGGCAGCACAGCCCTGCACTACTGCTGCC
TGACCGACAATGCCGAGTGCCTCAAGTTGCTCCTGCGGGGGAAGGCCTCCATCGAGATAGCAAACGAGTCAGGAGAGACTCCGCTGGACA
TTGCCAAGCGCCTCAAGCACGAGCACTGTGAGGAGCTGCTGACCCAAGCCTTATCTGGAAGATTTAATTCTCACGTTCACGTTGAATATG
AATGGCGACTACTCCACGAAGACCTGGATGAAAGTGATGACGACATGGATGAGAAATTGCAGCCCAGTCCCAACCGGCGGGAAGACCGGC
CCATCAGCTTCTACCAGCTGGGCTCCAACCAGCTTCAGTCTAACGCTGTATCTTTGGCCAGAGATGCTGCAAACCTTGCCAAGGAGAAGC
AGAGGGCTTTCATGCCCAGCATCTTGCAGAATGAGACTTACGGAGCCCTCCTGAGTGGCAGCCCACCTCCCGCCCAGCCTGCAGCCCCCA
GCACCACCAGCGCCCCCCCGCTTCCTCCACGGAATGTTGGCAAAGATCCCCTGACCCCCACGCCGCCCCCACCCGTTGCCAAGACGCCCA
GCGTAATGGAAGCCTTGAGCCAGCCGAGCAAGCCTGCCCCGCCTGGGATCTCACAGATCAGGCCCCCACCTCTGCCCCCACAGCCGCCCA
GCCGCCTCCCGCAGAAGAAGCCTGCGCCGGGGGCTGACAAGTCCACCCCACTGACCAACAAAGGCCAACCGAGAGGACCTGTGGATCTCT
CTGCAACGGAAGCTCTGGGTCCTCTGTCCAATGCTATGGTCCTGCAGCCCCCTGCACCCATGCCTAGGAAGTCGCAGGCAACCAAGTTGA
AGCCTAAGCGGGTGAAAGCGCTCTATAACTGTGTGGCTGACAACCCCGATGAGCTCACCTTCTCCGAGGGGGATGTGATCATCGTGGACG
GGGAGGAGGACCAGGAGTGGTGGATTGGCCACATTGATGGAGATCCTGGTCGCAAAGGCGCATTCCCGGTGTCATTTGTGCACTTTATCG
CTGACTGAATTGCTACTGAACAAAAGCATTAACAGTTATGTTCCTGTTTCGTTATTGGTACCAAAACTCTTGCCAGATAACCAGTTTCAT
GAACTGTTTGTATGGCAGCCCATGTTCTCTAATGCCACTGCTCTGTTTTAAAAACTCAGAGGCAATTTTTACATATCAGTAATTGTTTTT
ATAATTTGTGGTTTTCATGAAACATTGCTATGCATTTATTAGGAAAAACTGAATTTCCCAACAGGTGAACTGAAAAGTTATTTTAACTAT
TATACATAATCAAGATCCTGCCTCTACGGAATTAGCTAAACCTAAAAATGTTTGCATTAATGAATAAATTCTTCCTGCATTCCTTGGCCC
AGTTCTGGAGTTGGTGACCTTTATCACAATTATTATTTTAGGCGGCCAGTGAACTGCTGCTTCAGAAGTCCATAGCCCAGCTCTGAACTT
TCTCGATAAAATGCCATCAGTTCACCTTTAAAGACACACATTCCTTTGAAATCCACCCAGTGTTTAAAAAGCAACTTGGAAATTTACACA
TTAGCATTGTACTTTCTAGCCCTAATTTGTGAGGTTGCAGCTATCATTATATTCTGCATGTATGTATAACCTGTTGTGAACAATCATACT
TAACAAAACTACTGATGGTTTATGACAACGTAGGGTAACTACAGTTCATTCTGTTCCAGGTTATATAAAACTGCATTTCCTGAATTTGGT
TAAAAACTAAGGATGATGGATTGCAAAACAGTTCTTTTAAATTAGTTTATATGCTTTAGGTGTTTTGGAATTTGCCTTCTTGAACTTCCT
GAGTCACACAGAAAGCAACTGTACACAGTAGAATTCTGTGGCGCAGACCATGCTGTATTAACACATCACTTGCTGTTTCCTACTGAGTGT
ACCACTGCCTTCCCTTCTAGCCCAGGAGAATGTTTACTCAGTTTAGTGTCTTGTATTTCTATAATACTCCAACAGGAATGGTAGTCACAC
TGTCTTGAAATTGAATCTGTCCATCTGTTTATAATCAAGAACATATCAGAAATATATAGGTCCCAGGTAATACTCCCAAACATCCCACTT
TTTACTGTTTCAGGCCATCATATCATTCTTAAGCTACTTGGGGTGGTAGTAGAGGATTAGGTTGTCTATTATAAAACCAAAACTCATTCG
TTTAATGAACTTGACTGTCATACCTCTATTTAGTAATTGCGAGGGTAAGATTCATAGTAGGAATATTGGAAATTTTGGCACTCTGAGAAT
AAATAGGCATATGATACCCACTTGGACTTTTAACAAAAGTAAAGGAATAAATTTGCATATAGGCTTGGAAAGTGAGGCAGCAATGCTGTT
AACTGCATTTGTTGTGATGGTGCATTTGATTGAAGCAGCTTGTCTTTATTATGCAAGACTGTGTAGAGTTTTTTTTTTTTTTGGCATTGT
ACTTTTTGTTTTTGTTATAAAGGAAGACAGAACAAACTGGAATGTTTTATGATGTTGTATAGCAATCGCTTTTTACCTTTCAAAGTTCCG
GGTAAAAATGTGTTATATCTGTAGTTTTTTGTTTTTGTTTTTTTTTAAAGCACTACATCTGTTTTCACTAATTGTTAATTTCTGTTTGAA
CCCTTCATTTAATTTTCTCATAGATTTAAGTAAACAGATGTATTTTGCACAGTGCACTTATGTCTATTTTAACAATCCTCCTGCATCTGT
ATTTTATAGTCAGCCTTTTGACCACCTGGTGCCAGCTATATAAGGAATAAAGTTGATTCATATCAACATTAGAACTCCAGTCCCAAACTA
ATCTGTCAGGTTCACTGGTACATAAATACCTAGGAAATATTTTTCCAGTCTACAATTTGGTGCTATTGTGCAGTAACTAATAGTACTCTT
ACCAGAGGAGAAATTATATTAACGACCCTGCTAATATCCTTTCTTAGTTATTTGCTCCTTGCAAATTAAAAAAGCAACTAAGAGAAAGAA
AAACATTGTAGATATCTATTTATATTTAAAGTTTATGTTTCATGAACTGCAGCTGCAGGATTCTGGCATTTTGCATGCCATTCTCCATCA
GATCTGGGATGATGGCTCAGAACATGTACACAGACTAAGAGTAACTGTGTGATCTGTTAAGGGGTGGATAACATAATATGCAGCTTAGGA
TGCTATTTTGAGATGTATGATATTCAGTTCATTCACCTGATTACTTTGGTTGCAGCACAACTGTATATATTGTATAACCGAAATTGATTA
TTTTCATTGTCCTTAATGCAGTGATTTATAATTAGAGCATGTTTAATAAGTTTACTCTTCTTGTTAACTAGTCATTTGACTGGAAAAAAA

>75319_75319_2_ROCK2-ASAP2_ROCK2_chr2_11338617_ENST00000315872_ASAP2_chr2_9419446_ENST00000315273_length(amino acids)=1952AA_BP=1033
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAE
DYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNL
MSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGF
YGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWH
WDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLY
TLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQL
EDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESE
RRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNK
IYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDL
KMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQK
KQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKE
ELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCR
DDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDYETKITKIEKEKKEHAKLHGMIRTEIS
GAEIAEEMEKERRFFQLQMCEYLLKVNEIKIKKGVDLLQNLIKYFHAQCNFFQDGLKAVESLKPSIETLSTDLHTIKQAQDEERRQLIQL
RDILKSALQVEQKEDSQIRQSTAYSLHQPQGNKEHGTERNGSLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVKTN
PEEKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKEIISEVQRMTGNDVCCDCGAPDPTWLST
NLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKK
HADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFLVQNSGNLDKQTGKGSTALHYCC
LTDNAECLKLLLRGKASIEIANESGETPLDIAKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDMDEKLQPSPNRREDR
PISFYQLGSNQLQSNAVSLARDAANLAKEKQRAFMPSILQNETYGALLSGSPPPAQPAAPSTTSAPPLPPRNVGKDPLTPTPPPPVAKTP
SVMEALSQPSKPAPPGISQIRPPPLPPQPPSRLPQKKPAPGADKSTPLTNKGQPRGPVDLSATEALGPLSNAMVLQPPAPMPRKSQATKL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ROCK2-ASAP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneROCK2chr2:11338617chr2:9419446ENST00000315872-2533373_4201033.01389.0NPM1
HgeneROCK2chr2:11338617chr2:9419446ENST00000315872-2533363_7841033.01389.0PPP1R12A


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ROCK2-ASAP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ROCK2-ASAP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource