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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ROCK2-BTNL2 (FusionGDB2 ID:75320)

Fusion Gene Summary for ROCK2-BTNL2

Fusion gene summary

Fusion gene information	Fusion gene name: ROCK2-BTNL2
	Fusion gene ID: 75320
		Hgene	Tgene
	Gene symbol	ROCK2	BTNL2
	Gene ID	9475	56244
	Gene name	Rho associated coiled-coil containing protein kinase 2	butyrophilin like 2
	Synonyms	ROCK-II	BTL-II\|BTN7\|HSBLMHC1\|SS2
	Cytomap	2p25.1	6p21.32
	Type of gene	protein-coding	protein-coding
	Description	rho-associated protein kinase 2p164 ROCK-2rho-associated, coiled-coil-containing protein kinase II	butyrophilin-like protein 2butyrophilin-like 2 (MHC class II associated)truncated BTNL2
	Modification date	20200329	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000315872, ENST00000401753, ENST00000462366,	ENST00000414363, ENST00000544175, ENST00000374993, ENST00000374995, ENST00000429232, ENST00000540315, ENST00000546419, ENST00000546521, ENST00000546948, ENST00000547429, ENST00000547502, ENST00000547901, ENST00000548066, ENST00000548253, ENST00000548717, ENST00000548832, ENST00000548835, ENST00000548922, ENST00000549081, ENST00000549560, ENST00000549631, ENST00000549852, ENST00000549943, ENST00000550327, ENST00000550531, ENST00000550698, ENST00000551095, ENST00000551101, ENST00000551409, ENST00000551471, ENST00000551561, ENST00000551669, ENST00000551686, ENST00000551868, ENST00000552394, ENST00000552479, ENST00000552523, ENST00000552970, ENST00000553032, ENST00000553068, ENST00000454136,
Fusion gene scores	* DoF score	16 X 11 X 9=1584	1 X 1 X 1=1
	# samples	17	1
	** MAII score	log2(17/1584*10)=-3.21996568394191 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context	PubMed: ROCK2 [Title/Abstract] AND BTNL2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ROCK2(11351807)-BTNL2(32369582), # samples:1
Anticipated loss of major functional domain due to fusion event.	ROCK2-BTNL2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. ROCK2-BTNL2 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ROCK2	GO:0006468	protein phosphorylation	18559669

Fusion gene breakpoints across ROCK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across BTNL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-23-2077-01A	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-

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Fusion Gene ORF analysis for ROCK2-BTNL2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000315872	ENST00000414363	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-5UTR	ENST00000315872	ENST00000544175	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-5UTR	ENST00000401753	ENST00000414363	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-5UTR	ENST00000401753	ENST00000544175	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000374993	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000374995	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000429232	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000540315	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000546419	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000546521	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000546948	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000547429	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000547502	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000547901	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000548066	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000548253	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000548717	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000548832	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000548835	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000548922	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000549081	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000549560	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000549631	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000549852	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000549943	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000550327	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000550531	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000550698	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000551095	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000551101	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000551409	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000551471	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000551561	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000551669	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000551686	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000551868	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000552394	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000552479	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000552523	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000552970	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000553032	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000315872	ENST00000553068	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000374993	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000374995	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000429232	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000540315	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000546419	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000546521	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000546948	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000547429	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000547502	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000547901	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000548066	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000548253	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000548717	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000548832	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000548835	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000548922	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000549081	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000549560	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000549631	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000549852	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000549943	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000550327	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000550531	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000550698	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000551095	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000551101	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000551409	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000551471	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000551561	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000551669	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000551686	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000551868	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000552394	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000552479	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000552523	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000552970	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000553032	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
5CDS-intron	ENST00000401753	ENST00000553068	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
Frame-shift	ENST00000401753	ENST00000454136	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
In-frame	ENST00000315872	ENST00000454136	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-3CDS	ENST00000462366	ENST00000454136	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-5UTR	ENST00000462366	ENST00000414363	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-5UTR	ENST00000462366	ENST00000544175	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000374993	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000374995	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000429232	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000540315	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000546419	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000546521	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000546948	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000547429	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000547502	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000547901	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000548066	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000548253	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000548717	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000548832	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000548835	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000548922	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000549081	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000549560	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000549631	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000549852	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000549943	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000550327	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000550531	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000550698	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000551095	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000551101	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000551409	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000551471	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000551561	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000551669	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000551686	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000551868	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000552394	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000552479	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000552523	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000552970	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000553032	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-
intron-intron	ENST00000462366	ENST00000553068	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000315872

ROCK2

chr2

11351807

ENST00000454136

BTNL2

chr6

32369582

3398

2652

449

3391

980

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000315872	ENST00000454136	ROCK2	chr2	11351807	-	BTNL2	chr6	32369582	-	0.000715412	0.99928457

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Fusion Genomic Features for ROCK2-BTNL2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ROCK2-BTNL2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:11351807/chr6:32369582)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ROCK2

chr2:11351807

chr6:32369582

ENST00000315872

357_425

734

1389.0

Domain

AGC-kinase C-terminal

Hgene

ROCK2

chr2:11351807

chr6:32369582

ENST00000315872

497_573

734

1389.0

Domain

REM-1

Hgene

ROCK2

chr2:11351807

chr6:32369582

ENST00000315872

92_354

734

1389.0

Domain

Protein kinase

Hgene

ROCK2

chr2:11351807

chr6:32369582

ENST00000315872

98_106

734

1389.0

Nucleotide binding

ATP

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000374993

236_355

236

456.0

Domain

Note=Ig-like V-type 3

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000414363

142_234

246.0

Domain

Note=Ig-like V-type 2

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000414363

236_355

246.0

Domain

Note=Ig-like V-type 3

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000414363

29_140

246.0

Domain

Note=Ig-like V-type 1

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000544175

142_234

179.0

Domain

Note=Ig-like V-type 2

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000544175

236_355

179.0

Domain

Note=Ig-like V-type 3

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000544175

29_140

179.0

Domain

Note=Ig-like V-type 1

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000548253

142_234

246.0

Domain

Note=Ig-like V-type 2

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000548253

236_355

246.0

Domain

Note=Ig-like V-type 3

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000548253

29_140

246.0

Domain

Note=Ig-like V-type 1

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000548717

142_234

179.0

Domain

Note=Ig-like V-type 2

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000548717

236_355

179.0

Domain

Note=Ig-like V-type 3

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000548717

29_140

179.0

Domain

Note=Ig-like V-type 1

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000550327

142_234

456.0

Domain

Note=Ig-like V-type 2

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000550327

236_355

456.0

Domain

Note=Ig-like V-type 3

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000550327

29_140

456.0

Domain

Note=Ig-like V-type 1

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000550531

142_234

456.0

Domain

Note=Ig-like V-type 2

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000550531

236_355

456.0

Domain

Note=Ig-like V-type 3

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000550531

29_140

456.0

Domain

Note=Ig-like V-type 1

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000550698

142_234

179.0

Domain

Note=Ig-like V-type 2

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000550698

236_355

179.0

Domain

Note=Ig-like V-type 3

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000550698

29_140

179.0

Domain

Note=Ig-like V-type 1

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000551095

142_234

456.0

Domain

Note=Ig-like V-type 2

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000551095

236_355

456.0

Domain

Note=Ig-like V-type 3

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000551095

29_140

456.0

Domain

Note=Ig-like V-type 1

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000551669

142_234

179.0

Domain

Note=Ig-like V-type 2

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000551669

236_355

179.0

Domain

Note=Ig-like V-type 3

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000551669

29_140

179.0

Domain

Note=Ig-like V-type 1

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000551686

142_234

246.0

Domain

Note=Ig-like V-type 2

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000551686

236_355

246.0

Domain

Note=Ig-like V-type 3

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000551686

29_140

246.0

Domain

Note=Ig-like V-type 1

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000551868

142_234

246.0

Domain

Note=Ig-like V-type 2

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000551868

236_355

246.0

Domain

Note=Ig-like V-type 3

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000551868

29_140

246.0

Domain

Note=Ig-like V-type 1

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000552479

142_234

456.0

Domain

Note=Ig-like V-type 2

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000552479

236_355

456.0

Domain

Note=Ig-like V-type 3

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000552479

29_140

456.0

Domain

Note=Ig-like V-type 1

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000414363

24_455

246.0

Topological domain

Extracellular

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000544175

1_6

179.0

Topological domain

Cytoplasmic

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000544175

24_455

179.0

Topological domain

Extracellular

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000548253

1_6

246.0

Topological domain

Cytoplasmic

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000548253

24_455

246.0

Topological domain

Extracellular

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000548717

1_6

179.0

Topological domain

Cytoplasmic

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000548717

24_455

179.0

Topological domain

Extracellular

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000550327

1_6

456.0

Topological domain

Cytoplasmic

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000550327

24_455

456.0

Topological domain

Extracellular

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000550531

1_6

456.0

Topological domain

Cytoplasmic

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000550531

24_455

456.0

Topological domain

Extracellular

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000550698

1_6

179.0

Topological domain

Cytoplasmic

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000550698

24_455

179.0

Topological domain

Extracellular

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000551095

1_6

456.0

Topological domain

Cytoplasmic

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000551095

24_455

456.0

Topological domain

Extracellular

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000551669

1_6

179.0

Topological domain

Cytoplasmic

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000551669

24_455

179.0

Topological domain

Extracellular

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000551686

1_6

246.0

Topological domain

Cytoplasmic

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000551686

24_455

246.0

Topological domain

Extracellular

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000551868

1_6

246.0

Topological domain

Cytoplasmic

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000551868

24_455

246.0

Topological domain

Extracellular

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000552479

1_6

456.0

Topological domain

Cytoplasmic

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000552479

24_455

456.0

Topological domain

Extracellular

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000544175

7_23

179.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000548253

7_23

246.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000548717

7_23

179.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000550327

7_23

456.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000550531

7_23

456.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000550698

7_23

179.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000551095

7_23

456.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000551669

7_23

179.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000551686

7_23

246.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000551868

7_23

246.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000552479

7_23

456.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ROCK2

chr2:11351807

chr6:32369582

ENST00000315872

1053_1131

734

1389.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ROCK2

chr2:11351807

chr6:32369582

ENST00000315872

429_1024

734

1389.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ROCK2

chr2:11351807

chr6:32369582

ENST00000315872

1150_1349

734

1389.0

Domain

Hgene

ROCK2

chr2:11351807

chr6:32369582

ENST00000315872

979_1047

734

1389.0

Region

RHOA binding

Hgene

ROCK2

chr2:11351807

chr6:32369582

ENST00000315872

1260_1315

734

1389.0

Zinc finger

Phorbol-ester/DAG-type

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000374993

142_234

236

456.0

Domain

Note=Ig-like V-type 2

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000374993

29_140

236

456.0

Domain

Note=Ig-like V-type 1

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000374993

1_6

236

456.0

Topological domain

Cytoplasmic

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000374993

24_455

236

456.0

Topological domain

Extracellular

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000414363

1_6

246.0

Topological domain

Cytoplasmic

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000374993

7_23

236

456.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

BTNL2

chr2:11351807

chr6:32369582

ENST00000414363

7_23

246.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Top

Fusion Gene Sequence for ROCK2-BTNL2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>75320_75320_1_ROCK2-BTNL2_ROCK2_chr2_11351807_ENST00000315872_BTNL2_chr6_32369582_ENST00000454136_length(transcript)=3398nt_BP=2652nt
CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG
GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC
GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG
GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG
CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA
TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG
AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGGATGGCTTAAATTCCTTGGTCCTTGATTTAGATTTTCCTG
CTTTGAGGAAAAACAAGAACATAGATAATTTCTTAAATAGATATGAGAAAATTGTGAAAAAAATCAGAGGTCTACAGATGAAGGCAGAAG
ACTATGATGTTGTAAAAGTTATTGGAAGAGGTGCTTTTGGTGAAGTGCAGTTGGTTCGTCACAAGGCATCGCAGAAGGTTTATGCTATGA
AGCTTCTTAGTAAGTTTGAAATGATAAAAAGATCAGATTCTGCCTTTTTTTGGGAAGAAAGAGATATTATGGCCTTTGCCAATAGCCCCT
GGGTGGTTCAGCTTTTTTATGCCTTTCAAGATGATAGGTATCTGTACATGGTAATGGAGTACATGCCTGGTGGAGACCTTGTAAACCTTA
TGAGTAATTATGATGTGCCTGAAAAATGGGCCAAATTTTACACTGCTGAAGTTGTTCTTGCTCTGGATGCAATACACTCCATGGGTTTAA
TACACAGAGATGTGAAGCCTGACAACATGCTCTTGGATAAACATGGACATCTAAAATTAGCAGATTTTGGCACGTGTATGAAGATGGATG
AAACAGGCATGGTACATTGTGATACAGCAGTTGGAACACCGGATTATATATCACCTGAGGTTCTGAAATCACAAGGGGGTGATGGTTTCT
ATGGGCGAGAATGTGATTGGTGGTCTGTAGGTGTTTTCCTTTATGAGATGCTAGTGGGGGATACTCCATTTTATGCGGATTCACTTGTAG
GAACATATAGCAAAATTATGGATCATAAGAATTCACTGTGTTTCCCTGAAGATGCAGAAATTTCCAAACATGCAAAGAATCTCATCTGTG
CTTTCTTAACAGATAGGGAGGTACGACTTGGGAGAAATGGGGTGGAAGAAATCAGACAGCATCCTTTCTTTAAGAATGATCAGTGGCATT
GGGATAACATAAGAGAAACGGCAGCTCCTGTAGTACCTGAACTCAGCAGTGACATAGACAGCAGCAATTTCGATGACATTGAAGATGACA
AAGGAGATGTAGAAACCTTCCCAATTCCTAAAGCTTTTGTTGGAAATCAGCTGCCTTTCATCGGATTTACCTACTATAGAGAAAATTTAT
TATTAAGTGACTCTCCATCTTGTAGAGAAACTGATTCCATACAATCAAGGAAAAATGAAGAAAGTCAAGAGATTCAGAAAAAACTGTATA
CATTAGAAGAACATCTTAGCAATGAGATGCAAGCCAAAGAGGAACTGGAACAGAAGTGCAAATCTGTTAATACTCGCCTAGAAAAAACAG
CAAAGGAGCTAGAAGAGGAGATTACCTTACGGAAAAGTGTGGAATCAGCATTAAGACAGTTAGAAAGAGAAAAGGCGCTTCTTCAGCACA
AAAATGCAGAATATCAGAGGAAAGCTGATCATGAAGCAGACAAAAAACGAAATTTGGAAAATGATGTTAACAGCTTAAAAGATCAACTTG
AAGATTTGAAAAAAAGAAATCAAAACTCTCAAATATCCACTGAGAAAGTGAATCAACTCCAGAGACAACTGGATGAAACCAATGCTTTAC
TGCGAACAGAGTCTGATACTGCAGCCCGGTTAAGGAAAACCCAGGCAGAAAGTTCAAAACAGATTCAGCAGCTGGAATCTAACAATAGAG
ATCTACAAGATAAAAACTGCCTGCTGGAGACTGCCAAGTTAAAACTTGAAAAGGAATTTATCAATCTTCAGTCAGCTCTAGAATCTGAAA
GGAGGGATCGAACCCATGGATCAGAGATAATTAATGATTTACAAGGTAGAATATGTGGCCTAGAAGAAGATTTAAAGAACGGCAAAATCT
TACTAGCGAAAGTAGAACTGGAGAAGAGACAACTTCAGGAGAGATTTACTGATTTGGAAAAGGAAAAAAGCAACATGGAAATAGATATGA
CATACCAACTAAAAGTTATACAGCAGAGCCTAGAACAAGAAGAAGCTGAACATAAGGCCACAAAGGCACGACTAGCAGATAAAAATAAGA
TCTATGAGTCCATCGAAGAAGCCAAATCAGAAGCCATGAAAGAGAAACTCCAGACTGAGCTGGCTTCTTTAAAAGTGAATGGACCTTCCC
AGCCCATCCTCGTCAGAGTGGGAGAAGATATACAGCTAACCTGTTACCTGTCCCCCAAGGCGAATGCACAGAGCATGGAGGTGAGGTGGG
ACCGATCCCACCGTTACCCTGCTGTGCATGTGTATATGGATGGGGACCATGTGGCTGGAGAGCAGATGGCAGAGTACAGAGGGAGGACTG
TACTGGTGAGTGACGCCATTGACGAGGGCAGACTGACCCTGCAGATACTCAGTGCCAGACCTTCGGACGACGGGCAGTACCGCTGCCTTT
TTGAAAAAGATGATGTCTACCAGGAGGCCAGTTTGGATCTGAAGGTGGTAAGTCTGGGTTCTTCCCCACTGATCACTGTGGAGGGGCAAG
AAGATGGAGAAATGCAGCCGATGTGCTCTTCAGATGGGTGGTTCCCACAGCCCCACGTGCCATGGAGGGACATGGAAGGAAAGACGATAC
CATCATCTTCCCAGGCCCTGACTCAAGGCAGCCACGGGCTGTTCCACGTGCAGACATTGCTAAGGGTCACAAACATCTCCGCTGTGGACG
TCACTTGTTCCATCAGCATCCCCTTTTTGGGCGAGGAGAAAATCGCAACTTTTTCTCTCTCAGAGTCCAGGATGACGTTTTTGTGGAAAA

>75320_75320_1_ROCK2-BTNL2_ROCK2_chr2_11351807_ENST00000315872_BTNL2_chr6_32369582_ENST00000454136_length(amino acids)=980AA_BP=734
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAE
DYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNL
MSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGF
YGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWH
WDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLY
TLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQL
EDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESE
RRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNK
IYESIEEAKSEAMKEKLQTELASLKVNGPSQPILVRVGEDIQLTCYLSPKANAQSMEVRWDRSHRYPAVHVYMDGDHVAGEQMAEYRGRT
VLVSDAIDEGRLTLQILSARPSDDGQYRCLFEKDDVYQEASLDLKVVSLGSSPLITVEGQEDGEMQPMCSSDGWFPQPHVPWRDMEGKTI

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ROCK2-BTNL2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	ROCK2	chr2:11351807	chr6:32369582	ENST00000315872	-	18	33	373_420	734.3333333333334	1389.0	NPM1

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	ROCK2	chr2:11351807	chr6:32369582	ENST00000315872	-	18	33	363_784	734.3333333333334	1389.0	PPP1R12A

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ROCK2-BTNL2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ROCK2-BTNL2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source