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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ROMO1-HLA-DMB (FusionGDB2 ID:75343)

Fusion Gene Summary for ROMO1-HLA-DMB

Fusion gene summary

Fusion gene information	Fusion gene name: ROMO1-HLA-DMB
	Fusion gene ID: 75343
		Hgene	Tgene
	Gene symbol	ROMO1	HLA-DMB
	Gene ID	140823	3109
	Gene name	reactive oxygen species modulator 1	major histocompatibility complex, class II, DM beta
	Synonyms	C20orf52\|MTGM\|MTGMP\|bA353C18.2	D6S221E\|RING7
	Cytomap	20q11.22	6p21.32
	Type of gene	protein-coding	protein-coding
	Description	reactive oxygen species modulator 1PCM19ROS modulator 1epididymis tissue protein Li 175glyrichinmitochondrial targeting GXXXG proteinmitochondrial targeting GxxxG motif proteinprotein MGR2 homolog	HLA class II histocompatibility antigen, DM beta chainMHC class II HLA-DMBMHC class II antigen DMBMHC class II antigen HLA-DM beta chainclass II histocompatibility antigen, M beta chainreally interesting new gene 7 protein
	Modification date	20200313	20200313
	UniProtAcc	.	P28068
	Ensembl transtripts involved in fusion gene	ENST00000336695, ENST00000374072, ENST00000374077, ENST00000374078, ENST00000397416,	ENST00000383231, ENST00000395312, ENST00000412948, ENST00000413617, ENST00000416244, ENST00000418107, ENST00000418759, ENST00000424822, ENST00000428420, ENST00000428864, ENST00000439344, ENST00000440078, ENST00000447454, ENST00000450897, ENST00000452407, ENST00000456428, ENST00000546855, ENST00000547313, ENST00000547478, ENST00000548183, ENST00000548290, ENST00000548611, ENST00000549152, ENST00000549556, ENST00000550052, ENST00000551481, ENST00000552299, ENST00000552389,
Fusion gene scores	* DoF score	7 X 6 X 2=84	2 X 3 X 1=6
	# samples	8	3
	** MAII score	log2(8/84*10)=-0.070389327891398 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/6*10)=2.32192809488736
Context	PubMed: ROMO1 [Title/Abstract] AND HLA-DMB [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HLA-DMB(32907816)-ROMO1(34288902), # samples:1 ROMO1(34288902)-HLA-DMB(32907816), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ROMO1	GO:0008284	positive regulation of cell proliferation	18313394
Hgene	ROMO1	GO:0031640	killing of cells of other organism	22083756
Hgene	ROMO1	GO:0042742	defense response to bacterium	22083756
Hgene	ROMO1	GO:0050829	defense response to Gram-negative bacterium	22083756
Hgene	ROMO1	GO:0050830	defense response to Gram-positive bacterium	22083756
Hgene	ROMO1	GO:0051838	cytolysis by host of symbiont cells	22083756
Hgene	ROMO1	GO:2000379	positive regulation of reactive oxygen species metabolic process	16842742
Tgene	HLA-DMB	GO:0002503	peptide antigen assembly with MHC class II protein complex	7606781\|22733780

Fusion gene breakpoints across ROMO1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HLA-DMB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	CB050119	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+

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Fusion Gene ORF analysis for ROMO1-HLA-DMB

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000336695	ENST00000383231	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000336695	ENST00000395312	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000336695	ENST00000412948	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000336695	ENST00000413617	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000336695	ENST00000416244	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000336695	ENST00000418107	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000336695	ENST00000418759	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000336695	ENST00000424822	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000336695	ENST00000428420	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000336695	ENST00000428864	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000336695	ENST00000439344	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000336695	ENST00000440078	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000336695	ENST00000447454	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000336695	ENST00000450897	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000336695	ENST00000452407	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000336695	ENST00000456428	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000336695	ENST00000546855	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000336695	ENST00000547313	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000336695	ENST00000547478	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000336695	ENST00000548183	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000336695	ENST00000548290	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000336695	ENST00000548611	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000336695	ENST00000549152	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000336695	ENST00000549556	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000336695	ENST00000550052	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000336695	ENST00000551481	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000336695	ENST00000552299	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000336695	ENST00000552389	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374072	ENST00000383231	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374072	ENST00000395312	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374072	ENST00000412948	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374072	ENST00000413617	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374072	ENST00000416244	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374072	ENST00000418107	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374072	ENST00000418759	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374072	ENST00000424822	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374072	ENST00000428420	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374072	ENST00000428864	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374072	ENST00000439344	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374072	ENST00000440078	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374072	ENST00000447454	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374072	ENST00000450897	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374072	ENST00000452407	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374072	ENST00000456428	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374072	ENST00000546855	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374072	ENST00000547313	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374072	ENST00000547478	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374072	ENST00000548183	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374072	ENST00000548290	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374072	ENST00000548611	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374072	ENST00000549152	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374072	ENST00000549556	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374072	ENST00000550052	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374072	ENST00000551481	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374072	ENST00000552299	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374072	ENST00000552389	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374077	ENST00000383231	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374077	ENST00000395312	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374077	ENST00000412948	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374077	ENST00000413617	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374077	ENST00000416244	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374077	ENST00000418107	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374077	ENST00000418759	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374077	ENST00000424822	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374077	ENST00000428420	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374077	ENST00000428864	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374077	ENST00000439344	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374077	ENST00000440078	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374077	ENST00000447454	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374077	ENST00000450897	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374077	ENST00000452407	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374077	ENST00000456428	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374077	ENST00000546855	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374077	ENST00000547313	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374077	ENST00000547478	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374077	ENST00000548183	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374077	ENST00000548290	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374077	ENST00000548611	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374077	ENST00000549152	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374077	ENST00000549556	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374077	ENST00000550052	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374077	ENST00000551481	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374077	ENST00000552299	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374077	ENST00000552389	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374078	ENST00000383231	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374078	ENST00000395312	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374078	ENST00000412948	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374078	ENST00000413617	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374078	ENST00000416244	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374078	ENST00000418107	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374078	ENST00000418759	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374078	ENST00000424822	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374078	ENST00000428420	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374078	ENST00000428864	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374078	ENST00000439344	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374078	ENST00000440078	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374078	ENST00000447454	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374078	ENST00000450897	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374078	ENST00000452407	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374078	ENST00000456428	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374078	ENST00000546855	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374078	ENST00000547313	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374078	ENST00000547478	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374078	ENST00000548183	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374078	ENST00000548290	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374078	ENST00000548611	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374078	ENST00000549152	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374078	ENST00000549556	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374078	ENST00000550052	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374078	ENST00000551481	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374078	ENST00000552299	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
5CDS-intron	ENST00000374078	ENST00000552389	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
intron-intron	ENST00000397416	ENST00000383231	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
intron-intron	ENST00000397416	ENST00000395312	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
intron-intron	ENST00000397416	ENST00000412948	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
intron-intron	ENST00000397416	ENST00000413617	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
intron-intron	ENST00000397416	ENST00000416244	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
intron-intron	ENST00000397416	ENST00000418107	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
intron-intron	ENST00000397416	ENST00000418759	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
intron-intron	ENST00000397416	ENST00000424822	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
intron-intron	ENST00000397416	ENST00000428420	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
intron-intron	ENST00000397416	ENST00000428864	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
intron-intron	ENST00000397416	ENST00000439344	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
intron-intron	ENST00000397416	ENST00000440078	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
intron-intron	ENST00000397416	ENST00000447454	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
intron-intron	ENST00000397416	ENST00000450897	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
intron-intron	ENST00000397416	ENST00000452407	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
intron-intron	ENST00000397416	ENST00000456428	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
intron-intron	ENST00000397416	ENST00000546855	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
intron-intron	ENST00000397416	ENST00000547313	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
intron-intron	ENST00000397416	ENST00000547478	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
intron-intron	ENST00000397416	ENST00000548183	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
intron-intron	ENST00000397416	ENST00000548290	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
intron-intron	ENST00000397416	ENST00000548611	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
intron-intron	ENST00000397416	ENST00000549152	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
intron-intron	ENST00000397416	ENST00000549556	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
intron-intron	ENST00000397416	ENST00000550052	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
intron-intron	ENST00000397416	ENST00000551481	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
intron-intron	ENST00000397416	ENST00000552299	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+
intron-intron	ENST00000397416	ENST00000552389	ROMO1	chr20	34288902	+	HLA-DMB	chr6	32907816	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for ROMO1-HLA-DMB

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ROMO1-HLA-DMB

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:32907816/:34288902)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	HLA-DMB P28068
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. {ECO:0000269\|PubMed:16547258, ECO:0000269\|PubMed:23260142, ECO:0000269\|PubMed:8849454, ECO:0000269\|PubMed:9768757}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for ROMO1-HLA-DMB

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ROMO1-HLA-DMB

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ROMO1-HLA-DMB

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ROMO1-HLA-DMB

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source