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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ROR1-IL12RB2 (FusionGDB2 ID:75361)

Fusion Gene Summary for ROR1-IL12RB2

check button Fusion gene summary
Fusion gene informationFusion gene name: ROR1-IL12RB2
Fusion gene ID: 75361
HgeneTgene
Gene symbol

ROR1

IL12RB2

Gene ID

6095

3595

Gene nameRAR related orphan receptor Ainterleukin 12 receptor subunit beta 2
SynonymsIDDECA|NR1F1|ROR1|ROR2|ROR3|RZR-ALPHA|RZRA-
Cytomap

15q22.2

1p31.3

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor ROR-alphaROR-alphanuclear receptor RZR-alphanuclear receptor subfamily 1 group F member 1retinoic acid receptor-related orphan receptor alpharetinoid-related orphan receptor alphathyroid hormone nuclear receptor alpha variant 4traninterleukin-12 receptor subunit beta-2IL-12 receptor subunit beta-2IL-12R subunit beta-2interleukin 12 receptor, beta 2interleukin-12 receptor beta-2 chain
Modification date2020032220200315
UniProtAcc.

Q99665

Ensembl transtripts involved in fusion geneENST00000482426, ENST00000371079, 
ENST00000371080, ENST00000545203, 
ENST00000262345, ENST00000371000, 
ENST00000541374, ENST00000544434, 
ENST00000465396, 
Fusion gene scores* DoF score15 X 10 X 7=10503 X 4 X 3=36
# samples 174
** MAII scorelog2(17/1050*10)=-2.62678267641578
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ROR1 [Title/Abstract] AND IL12RB2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointROR1(64475048)-IL12RB2(67787285), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneROR1

GO:0006355

regulation of transcription, DNA-templated

9328355

HgeneROR1

GO:0030522

intracellular receptor signaling pathway

19965867

HgeneROR1

GO:0036315

cellular response to sterol

19965867

HgeneROR1

GO:0045893

positive regulation of transcription, DNA-templated

7926749

HgeneROR1

GO:0045944

positive regulation of transcription by RNA polymerase II

17545671|19955433

TgeneIL12RB2

GO:0032729

positive regulation of interferon-gamma production

11114383


check buttonFusion gene breakpoints across ROR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IL12RB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-ER-A2NG-06AROR1chr1

64475048

-IL12RB2chr1

67787285

+


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Fusion Gene ORF analysis for ROR1-IL12RB2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000482426ENST00000262345ROR1chr1

64475048

-IL12RB2chr1

67787285

+
3UTR-3CDSENST00000482426ENST00000371000ROR1chr1

64475048

-IL12RB2chr1

67787285

+
3UTR-3CDSENST00000482426ENST00000541374ROR1chr1

64475048

-IL12RB2chr1

67787285

+
3UTR-3CDSENST00000482426ENST00000544434ROR1chr1

64475048

-IL12RB2chr1

67787285

+
3UTR-intronENST00000482426ENST00000465396ROR1chr1

64475048

-IL12RB2chr1

67787285

+
5CDS-intronENST00000371079ENST00000465396ROR1chr1

64475048

-IL12RB2chr1

67787285

+
5CDS-intronENST00000371080ENST00000465396ROR1chr1

64475048

-IL12RB2chr1

67787285

+
In-frameENST00000371079ENST00000262345ROR1chr1

64475048

-IL12RB2chr1

67787285

+
In-frameENST00000371079ENST00000371000ROR1chr1

64475048

-IL12RB2chr1

67787285

+
In-frameENST00000371079ENST00000541374ROR1chr1

64475048

-IL12RB2chr1

67787285

+
In-frameENST00000371079ENST00000544434ROR1chr1

64475048

-IL12RB2chr1

67787285

+
In-frameENST00000371080ENST00000262345ROR1chr1

64475048

-IL12RB2chr1

67787285

+
In-frameENST00000371080ENST00000371000ROR1chr1

64475048

-IL12RB2chr1

67787285

+
In-frameENST00000371080ENST00000541374ROR1chr1

64475048

-IL12RB2chr1

67787285

+
In-frameENST00000371080ENST00000544434ROR1chr1

64475048

-IL12RB2chr1

67787285

+
intron-3CDSENST00000545203ENST00000262345ROR1chr1

64475048

-IL12RB2chr1

67787285

+
intron-3CDSENST00000545203ENST00000371000ROR1chr1

64475048

-IL12RB2chr1

67787285

+
intron-3CDSENST00000545203ENST00000541374ROR1chr1

64475048

-IL12RB2chr1

67787285

+
intron-3CDSENST00000545203ENST00000544434ROR1chr1

64475048

-IL12RB2chr1

67787285

+
intron-intronENST00000545203ENST00000465396ROR1chr1

64475048

-IL12RB2chr1

67787285

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371080ROR1chr164475048-ENST00000371000IL12RB2chr167787285+37835593572462701
ENST00000371080ROR1chr164475048-ENST00000262345IL12RB2chr167787285+38835593573071904
ENST00000371080ROR1chr164475048-ENST00000541374IL12RB2chr167787285+27185593572462701
ENST00000371080ROR1chr164475048-ENST00000544434IL12RB2chr167787285+28725593572813818
ENST00000371079ROR1chr164475048-ENST00000371000IL12RB2chr167787285+37625383362441701
ENST00000371079ROR1chr164475048-ENST00000262345IL12RB2chr167787285+38625383363050904
ENST00000371079ROR1chr164475048-ENST00000541374IL12RB2chr167787285+26975383362441701
ENST00000371079ROR1chr164475048-ENST00000544434IL12RB2chr167787285+28515383362792818

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371080ENST00000371000ROR1chr164475048-IL12RB2chr167787285+0.0120790850.9879209
ENST00000371080ENST00000262345ROR1chr164475048-IL12RB2chr167787285+0.002901670.9970983
ENST00000371080ENST00000541374ROR1chr164475048-IL12RB2chr167787285+0.0159594440.98404056
ENST00000371080ENST00000544434ROR1chr164475048-IL12RB2chr167787285+0.0059866940.99401337
ENST00000371079ENST00000371000ROR1chr164475048-IL12RB2chr167787285+0.0124533420.9875466
ENST00000371079ENST00000262345ROR1chr164475048-IL12RB2chr167787285+0.0030061430.9969939
ENST00000371079ENST00000541374ROR1chr164475048-IL12RB2chr167787285+0.0164107590.9835893
ENST00000371079ENST00000544434ROR1chr164475048-IL12RB2chr167787285+0.0061963130.9938036

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Fusion Genomic Features for ROR1-IL12RB2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ROR1-IL12RB2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:64475048/chr1:67787285)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.IL12RB2

Q99665

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000262345116208_21125863.0Compositional biasNote=Poly-Ser
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000262345116750_75325863.0Compositional biasNote=Poly-Pro
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000371000115208_21125660.0Compositional biasNote=Poly-Ser
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000371000115750_75325660.0Compositional biasNote=Poly-Pro
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000541374216208_21125660.0Compositional biasNote=Poly-Ser
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000541374216750_75325660.0Compositional biasNote=Poly-Pro
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000544434114208_21125777.0Compositional biasNote=Poly-Ser
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000544434114750_75325777.0Compositional biasNote=Poly-Pro
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000262345116126_22125863.0DomainFibronectin type-III 1
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000262345116226_31925863.0DomainFibronectin type-III 2
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000262345116320_41925863.0DomainFibronectin type-III 3
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000262345116423_52025863.0DomainFibronectin type-III 4
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000262345116521_62025863.0DomainFibronectin type-III 5
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000371000115126_22125660.0DomainFibronectin type-III 1
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000371000115226_31925660.0DomainFibronectin type-III 2
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000371000115320_41925660.0DomainFibronectin type-III 3
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000371000115423_52025660.0DomainFibronectin type-III 4
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000371000115521_62025660.0DomainFibronectin type-III 5
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000541374216126_22125660.0DomainFibronectin type-III 1
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000541374216226_31925660.0DomainFibronectin type-III 2
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000541374216320_41925660.0DomainFibronectin type-III 3
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000541374216423_52025660.0DomainFibronectin type-III 4
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000541374216521_62025660.0DomainFibronectin type-III 5
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000544434114126_22125777.0DomainFibronectin type-III 1
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000544434114226_31925777.0DomainFibronectin type-III 2
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000544434114320_41925777.0DomainFibronectin type-III 3
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000544434114423_52025777.0DomainFibronectin type-III 4
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000544434114521_62025777.0DomainFibronectin type-III 5
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000262345116305_30925863.0MotifNote=WSXWS motif
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000262345116662_67025863.0MotifNote=Box 1 motif
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000371000115305_30925660.0MotifNote=WSXWS motif
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000371000115662_67025660.0MotifNote=Box 1 motif
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000541374216305_30925660.0MotifNote=WSXWS motif
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000541374216662_67025660.0MotifNote=Box 1 motif
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000544434114305_30925777.0MotifNote=WSXWS motif
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000544434114662_67025777.0MotifNote=Box 1 motif
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000262345116796_80125863.0RegionNote=Required for STAT4 binding
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000371000115796_80125660.0RegionNote=Required for STAT4 binding
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000541374216796_80125660.0RegionNote=Required for STAT4 binding
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000544434114796_80125777.0RegionNote=Required for STAT4 binding
TgeneIL12RB2chr1:64475048chr1:67787285ENST0000026234511624_62225863.0Topological domainExtracellular
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000262345116644_86225863.0Topological domainCytoplasmic
TgeneIL12RB2chr1:64475048chr1:67787285ENST0000037100011524_62225660.0Topological domainExtracellular
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000371000115644_86225660.0Topological domainCytoplasmic
TgeneIL12RB2chr1:64475048chr1:67787285ENST0000054137421624_62225660.0Topological domainExtracellular
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000541374216644_86225660.0Topological domainCytoplasmic
TgeneIL12RB2chr1:64475048chr1:67787285ENST0000054443411424_62225777.0Topological domainExtracellular
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000544434114644_86225777.0Topological domainCytoplasmic
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000262345116623_64325863.0TransmembraneHelical
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000371000115623_64325660.0TransmembraneHelical
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000541374216623_64325660.0TransmembraneHelical
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000544434114623_64325777.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneROR1chr1:64475048chr1:67787285ENST00000371079-29753_78254938.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64475048chr1:67787285ENST00000371079-29784_85154938.0Compositional biasNote=Pro-rich
HgeneROR1chr1:64475048chr1:67787285ENST00000371079-29853_87654938.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64475048chr1:67787285ENST00000371080-27753_78254394.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64475048chr1:67787285ENST00000371080-27784_85154394.0Compositional biasNote=Pro-rich
HgeneROR1chr1:64475048chr1:67787285ENST00000371080-27853_87654394.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64475048chr1:67787285ENST00000545203-16753_7820389.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64475048chr1:67787285ENST00000545203-16784_8510389.0Compositional biasNote=Pro-rich
HgeneROR1chr1:64475048chr1:67787285ENST00000545203-16853_8760389.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64475048chr1:67787285ENST00000371079-29165_29954938.0DomainFZ
HgeneROR1chr1:64475048chr1:67787285ENST00000371079-29312_39154938.0DomainKringle
HgeneROR1chr1:64475048chr1:67787285ENST00000371079-2942_14754938.0DomainNote=Ig-like C2-type
HgeneROR1chr1:64475048chr1:67787285ENST00000371079-29473_74654938.0DomainProtein kinase
HgeneROR1chr1:64475048chr1:67787285ENST00000371080-27165_29954394.0DomainFZ
HgeneROR1chr1:64475048chr1:67787285ENST00000371080-27312_39154394.0DomainKringle
HgeneROR1chr1:64475048chr1:67787285ENST00000371080-2742_14754394.0DomainNote=Ig-like C2-type
HgeneROR1chr1:64475048chr1:67787285ENST00000371080-27473_74654394.0DomainProtein kinase
HgeneROR1chr1:64475048chr1:67787285ENST00000545203-16165_2990389.0DomainFZ
HgeneROR1chr1:64475048chr1:67787285ENST00000545203-16312_3910389.0DomainKringle
HgeneROR1chr1:64475048chr1:67787285ENST00000545203-1642_1470389.0DomainNote=Ig-like C2-type
HgeneROR1chr1:64475048chr1:67787285ENST00000545203-16473_7460389.0DomainProtein kinase
HgeneROR1chr1:64475048chr1:67787285ENST00000371079-29479_48754938.0Nucleotide bindingATP
HgeneROR1chr1:64475048chr1:67787285ENST00000371080-27479_48754394.0Nucleotide bindingATP
HgeneROR1chr1:64475048chr1:67787285ENST00000545203-16479_4870389.0Nucleotide bindingATP
HgeneROR1chr1:64475048chr1:67787285ENST00000371079-2930_40654938.0Topological domainExtracellular
HgeneROR1chr1:64475048chr1:67787285ENST00000371079-29428_93754938.0Topological domainCytoplasmic
HgeneROR1chr1:64475048chr1:67787285ENST00000371080-2730_40654394.0Topological domainExtracellular
HgeneROR1chr1:64475048chr1:67787285ENST00000371080-27428_93754394.0Topological domainCytoplasmic
HgeneROR1chr1:64475048chr1:67787285ENST00000545203-1630_4060389.0Topological domainExtracellular
HgeneROR1chr1:64475048chr1:67787285ENST00000545203-16428_9370389.0Topological domainCytoplasmic
HgeneROR1chr1:64475048chr1:67787285ENST00000371079-29407_42754938.0TransmembraneHelical
HgeneROR1chr1:64475048chr1:67787285ENST00000371080-27407_42754394.0TransmembraneHelical
HgeneROR1chr1:64475048chr1:67787285ENST00000545203-16407_4270389.0TransmembraneHelical


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Fusion Gene Sequence for ROR1-IL12RB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>75361_75361_1_ROR1-IL12RB2_ROR1_chr1_64475048_ENST00000371079_IL12RB2_chr1_67787285_ENST00000262345_length(transcript)=3862nt_BP=538nt
GAGCTGGAGCAGCCGCCACCGCCGCCGCCGAGGGAGCCCCGGGACGGCAGCCCCTGGGCGCAGGGTGCGCTGTTCTCGGAGTCCGACCCA
GGGCGACTCACGCCCACTGGTGCGACCCGGACAGCCTGGGACTGACCCGCCGGCCCAGGCGAGGCTGCAGCCAGAGGGCTGGGAAGGGAT
CGCGCTCGCGGCATCCAGAGGCGGCCAGGCGGAGGCGAGGGAGCAGGTTAGAGGGACAAAGAGCTTTGCAGACGTCCCCGGCGTCCTGCG
AGCGCCAGCGGCCGGGACGAGGCGGCCGGGAGCCCGGGAAGAGCCCGTGGATGTTCTGCGCGCGGCCTGGGAGCCGCCGCCGCCGCCGCC
TCAGCGAGAGGAGGAATGCACCGGCCGCGCCGCCGCGGGACGCGCCCGCCGCTCCTGGCGCTGCTGGCCGCGCTGCTGCTGGCCGCACGC
GGGGCTGCTGCCCAAGAAACAGAGCTGTCAGTCAGTGCTGAATTAGTGCCTACCTCATCATGGAACATCTCAAGTGAACTCAACAAAGAT
GCGTGCAAGAGAGGCGATGTGACTGTGAAGCCTTCCCATGTAATTTTACTTGGATCCACTGTCAATATTACATGCTCTTTGAAGCCCAGA
CAAGGCTGCTTTCACTATTCCAGACGTAACAAGTTAATCCTGTACAAGTTTGACAGAAGAATCAATTTTCACCATGGCCACTCCCTCAAT
TCTCAAGTCACAGGTCTTCCCCTTGGTACAACCTTGTTTGTCTGCAAACTGGCCTGTATCAATAGTGATGAAATTCAAATATGTGGAGCA
GAGATCTTCGTTGGTGTTGCTCCAGAACAGCCTCAAAATTTATCCTGCATACAGAAGGGAGAACAGGGGACTGTGGCCTGCACCTGGGAA
AGAGGACGAGACACCCACTTATACACTGAGTATACTCTACAGCTAAGTGGACCAAAAAATTTAACCTGGCAGAAGCAATGTAAAGACATT
TATTGTGACTATTTGGACTTTGGAATCAACCTCACCCCTGAATCACCTGAATCCAATTTCACAGCCAAGGTTACTGCTGTCAATAGTCTT
GGAAGCTCCTCTTCACTTCCATCCACATTCACATTCTTGGACATAGTGAGGCCTCTTCCTCCGTGGGACATTAGAATCAAATTTCAAAAG
GCTTCTGTGAGCAGATGTACCCTTTATTGGAGAGATGAGGGACTGGTACTGCTTAATCGACTCAGATATCGGCCCAGTAACAGCAGGCTC
TGGAATATGGTTAATGTTACAAAGGCCAAAGGAAGACATGATTTGCTGGATCTGAAACCATTTACAGAATATGAATTTCAGATTTCCTCT
AAGCTACATCTTTATAAGGGAAGTTGGAGTGATTGGAGTGAATCATTGAGAGCACAAACACCAGAAGAAGAGCCTACTGGGATGTTAGAT
GTCTGGTACATGAAACGGCACATTGACTACAGTAGACAACAGATTTCTCTTTTCTGGAAGAATCTGAGTGTCTCAGAGGCAAGAGGAAAA
ATTCTCCACTATCAGGTGACCTTGCAGGAGCTGACAGGAGGGAAAGCCATGACACAGAACATCACAGGACACACCTCCTGGACCACAGTC
ATTCCTAGAACCGGAAATTGGGCTGTGGCTGTGTCTGCAGCAAATTCAAAAGGCAGTTCTCTGCCCACTCGTATTAACATAATGAACCTG
TGTGAGGCAGGGTTGCTGGCTCCTCGCCAGGTCTCTGCAAACTCAGAGGGCATGGACAACATTCTGGTGACTTGGCAGCCTCCCAGGAAA
GATCCCTCTGCTGTTCAGGAGTACGTGGTGGAATGGAGAGAGCTCCATCCAGGGGGTGACACACAGGTCCCTCTAAACTGGCTACGGAGT
CGACCCTACAATGTGTCTGCTCTGATTTCAGAGAACATAAAATCCTACATCTGTTATGAAATCCGTGTGTATGCACTCTCAGGGGATCAA
GGAGGATGCAGCTCCATCCTGGGTAACTCTAAGCACAAAGCACCACTGAGTGGCCCCCACATTAATGCCATCACAGAGGAAAAGGGGAGC
ATTTTAATTTCATGGAACAGCATTCCAGTCCAGGAGCAAATGGGCTGCCTCCTCCATTATAGGATATACTGGAAGGAACGGGACTCCAAC
TCCCAGCCTCAGCTCTGTGAAATTCCCTACAGAGTCTCCCAAAATTCACATCCAATAAACAGCCTGCAGCCCCGAGTGACATATGTCCTG
TGGATGACAGCTCTGACAGCTGCTGGTGAAAGTTCCCACGGAAATGAGAGGGAATTTTGTCTGCAAGGTAAAGCCAATTGGATGGCGTTT
GTGGCACCAAGCATTTGCATTGCTATCATCATGGTGGGCATTTTCTCAACGCATTACTTCCAGCAAAAGGTGTTTGTTCTCCTAGCAGCC
CTCAGACCTCAGTGGTGTAGCAGAGAAATTCCAGATCCAGCAAATAGCACTTGCGCTAAGAAATATCCCATTGCAGAGGAGAAGACACAG
CTGCCCTTGGACAGGCTCCTGATAGACTGGCCCACGCCTGAAGATCCTGAACCGCTGGTCATCAGTGAAGTCCTTCATCAAGTGACCCCA
GTTTTCAGACATCCCCCCTGCTCCAACTGGCCACAAAGGGAAAAAGGAATCCAAGGTCATCAGGCCTCTGAGAAAGACATGATGCACAGT
GCCTCAAGCCCACCACCTCCAAGAGCTCTCCAAGCTGAGAGCAGACAACTGGTGGATCTGTACAAGGTGCTGGAGAGCAGGGGCTCCGAC
CCAAAGCCCGAAAACCCAGCCTGTCCCTGGACGGTGCTCCCAGCAGGTGACCTTCCCACCCATGATGGCTACTTACCCTCCAACATAGAT
GACCTCCCCTCACATGAGGCACCTCTCGCTGACTCTCTGGAAGAACTGGAGCCTCAGCACATCTCCCTTTCTGTTTTCCCCTCAAGTTCT
CTTCACCCACTCACCTTCTCCTGTGGTGATAAGCTGACTCTGGATCAGTTAAAGATGAGGTGTGACTCCCTCATGCTCTGAGTGGTGAGG
CTTCAAGCCTTAAAGTCAGTGTGCCCTCAACCAGCACAGCCTGCCCCAATTCCCCCAGCCCCTGCTCCAGCAGCTGTCATCTCTGGGTGC
CACCATCGGTCTGGCTGCAGCTAGAGGACAGGCAAGCCAGCTCTGGGGGAGTCTTAGGAACTGGGAGTTGGTCTTCACTCAGATGCCTCA
TCTTGCCTTTCCCAGGGCCTTAAAATTACATCCTTCACTGTGTGGACCTAGAGACTCCAACTTGAATTCCTAGTAACTTTCTTGGTATGC
TGGCCAGAAAGGGAAATGAGGAGGAGAGTAGAAACCACAGCTCTTAGTAGTAATGGCATACAGTCTAGAGGACCATTCATGCAATGACTA
TTTCTAAAGCACCTGCTACACAGCAGGCTGTACACAGCAGATCAGTACTGTTCAACAGAACTTCCTGAGATGATGGAAATGTTCTACCTC
TGCACTCACTGTCCAGTACATTAGACACTAGGCACATTGGCTGTTAATCACTTGGAATGTGTTTAGCTTGACTGAGGAATTAAATTTTGA
TTGTAAATTTAAATCGCCACACATGGCTAGTGGCTACTGTATTGGAGTGCACAGCTCTAGATGGCTCCTAGATTATTGAGAGCCTTCAAA
ACAAATCAACCTAGTTCTATAGATGAAGACATAAAAGACACTGGTAAACACCAAGGTAAAAGGGCCCCCAAGGTGGTCATGACTGGTCTC

>75361_75361_1_ROR1-IL12RB2_ROR1_chr1_64475048_ENST00000371079_IL12RB2_chr1_67787285_ENST00000262345_length(amino acids)=904AA_BP=67
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDACKRGDVTVKPSHVILLGSTVN
ITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCKLACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQ
GTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPW
DIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPE
EEPTGMLDVWYMKRHIDYSRQQISLFWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGSSLP
TRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALISENIKSYICYEIR
VYALSGDQGGCSSILGNSKHKAPLSGPHINAITEEKGSILISWNSIPVQEQMGCLLHYRIYWKERDSNSQPQLCEIPYRVSQNSHPINSL
QPRVTYVLWMTALTAAGESSHGNEREFCLQGKANWMAFVAPSICIAIIMVGIFSTHYFQQKVFVLLAALRPQWCSREIPDPANSTCAKKY
PIAEEKTQLPLDRLLIDWPTPEDPEPLVISEVLHQVTPVFRHPPCSNWPQREKGIQGHQASEKDMMHSASSPPPPRALQAESRQLVDLYK
VLESRGSDPKPENPACPWTVLPAGDLPTHDGYLPSNIDDLPSHEAPLADSLEELEPQHISLSVFPSSSLHPLTFSCGDKLTLDQLKMRCD

--------------------------------------------------------------
>75361_75361_2_ROR1-IL12RB2_ROR1_chr1_64475048_ENST00000371079_IL12RB2_chr1_67787285_ENST00000371000_length(transcript)=3762nt_BP=538nt
GAGCTGGAGCAGCCGCCACCGCCGCCGCCGAGGGAGCCCCGGGACGGCAGCCCCTGGGCGCAGGGTGCGCTGTTCTCGGAGTCCGACCCA
GGGCGACTCACGCCCACTGGTGCGACCCGGACAGCCTGGGACTGACCCGCCGGCCCAGGCGAGGCTGCAGCCAGAGGGCTGGGAAGGGAT
CGCGCTCGCGGCATCCAGAGGCGGCCAGGCGGAGGCGAGGGAGCAGGTTAGAGGGACAAAGAGCTTTGCAGACGTCCCCGGCGTCCTGCG
AGCGCCAGCGGCCGGGACGAGGCGGCCGGGAGCCCGGGAAGAGCCCGTGGATGTTCTGCGCGCGGCCTGGGAGCCGCCGCCGCCGCCGCC
TCAGCGAGAGGAGGAATGCACCGGCCGCGCCGCCGCGGGACGCGCCCGCCGCTCCTGGCGCTGCTGGCCGCGCTGCTGCTGGCCGCACGC
GGGGCTGCTGCCCAAGAAACAGAGCTGTCAGTCAGTGCTGAATTAGTGCCTACCTCATCATGGAACATCTCAAGTGAACTCAACAAAGAT
GCGTGCAAGAGAGGCGATGTGACTGTGAAGCCTTCCCATGTAATTTTACTTGGATCCACTGTCAATATTACATGCTCTTTGAAGCCCAGA
CAAGGCTGCTTTCACTATTCCAGACGTAACAAGTTAATCCTGTACAAGTTTGACAGAAGAATCAATTTTCACCATGGCCACTCCCTCAAT
TCTCAAGTCACAGGTCTTCCCCTTGGTACAACCTTGTTTGTCTGCAAACTGGCCTGTATCAATAGTGATGAAATTCAAATATGTGGAGCA
GAGATCTTCGTTGGTGTTGCTCCAGAACAGCCTCAAAATTTATCCTGCATACAGAAGGGAGAACAGGGGACTGTGGCCTGCACCTGGGAA
AGAGGACGAGACACCCACTTATACACTGAGTATACTCTACAGCTAAGTGGACCAAAAAATTTAACCTGGCAGAAGCAATGTAAAGACATT
TATTGTGACTATTTGGACTTTGGAATCAACCTCACCCCTGAATCACCTGAATCCAATTTCACAGCCAAGGTTACTGCTGTCAATAGTCTT
GGAAGCTCCTCTTCACTTCCATCCACATTCACATTCTTGGACATAGTGAGGCCTCTTCCTCCGTGGGACATTAGAATCAAATTTCAAAAG
GCTTCTGTGAGCAGATGTACCCTTTATTGGAGAGATGAGGGACTGGTACTGCTTAATCGACTCAGATATCGGCCCAGTAACAGCAGGCTC
TGGAATATGGTTAATGTTACAAAGGCCAAAGGAAGACATGATTTGCTGGATCTGAAACCATTTACAGAATATGAATTTCAGATTTCCTCT
AAGCTACATCTTTATAAGGGAAGTTGGAGTGATTGGAGTGAATCATTGAGAGCACAAACACCAGAAGAAGAGCCTACTGGGATGTTAGAT
GTCTGGTACATGAAACGGCACATTGACTACAGTAGACAACAGATTTCTCTTTTCTGGAAGAATCTGAGTGTCTCAGAGGCAAGAGGAAAA
ATTCTCCACTATCAGGTGACCTTGCAGGAGCTGACAGGAGGGAAAGCCATGACACAGAACATCACAGGACACACCTCCTGGACCACAGTC
ATTCCTAGAACCGGAAATTGGGCTGTGGCTGTGTCTGCAGCAAATTCAAAAGGCAGTTCTCTGCCCACTCGTATTAACATAATGAACCTG
TGTGAGGCAGGGTTGCTGGCTCCTCGCCAGGTCTCTGCAAACTCAGAGGGCATGGACAACATTCTGGTGACTTGGCAGCCTCCCAGGAAA
GATCCCTCTGCTGTTCAGGAGTACGTGGTGGAATGGAGAGAGCTCCATCCAGGGGGTGACACACAGGTCCCTCTAAACTGGCTACGGAGT
CGACCCTACAATGTGTCTGCTCTGATTTCAGAGAACATAAAATCCTACATCTGTTATGAAATCCGTGTGTATGCACTCTCAGGGGATCAA
GGAGGATGCAGCTCCATCCTGGGTAACTCTAAGCACAAAGCACCACTGAGTGGCCCCCACATTAATGCCATCACAGAGGAAAAGGGGAGC
ATTTTAATTTCATGGAACAGCATTCCAGTCCAGGAGCAAATGGGCTGCCTCCTCCATTATAGGATATACTGGAAGGAACGGGACTCCAAC
TCCCAGCCTCAGCTCTGTGAAATTCCCTACAGAGTCTCCCAAAATTCACATCCAATAAACAGCCTGCAGCCCCGAGTGACATATGTCCTG
TGGATGACAGCTCTGACAGCTGCTGGTGAAAGTTCCCACGGAAATGAGAGGGAATTTTGTCTGCAAGGTAAAGCCAATTGGATGGCGTTT
GTGGCACCAAGCATTTGCATTGCTATCATCATGGTGGGCATTTTCTCAACGCATTACTTCCAGCAAAAGAGAAGACACAGCTGCCCTTGG
ACAGGCTCCTGATAGACTGGCCCACGCCTGAAGATCCTGAACCGCTGGTCATCAGTGAAGTCCTTCATCAAGTGACCCCAGTTTTCAGAC
ATCCCCCCTGCTCCAACTGGCCACAAAGGGAAAAAGGAATCCAAGGTCATCAGGCCTCTGAGAAAGACATGATGCACAGTGCCTCAAGCC
CACCACCTCCAAGAGCTCTCCAAGCTGAGAGCAGACAACTGGTGGATCTGTACAAGGTGCTGGAGAGCAGGGGCTCCGACCCAAAGCCCG
AAAACCCAGCCTGTCCCTGGACGGTGCTCCCAGCAGGTGACCTTCCCACCCATGATGGCTACTTACCCTCCAACATAGATGACCTCCCCT
CACATGAGGCACCTCTCGCTGACTCTCTGGAAGAACTGGAGCCTCAGCACATCTCCCTTTCTGTTTTCCCCTCAAGTTCTCTTCACCCAC
TCACCTTCTCCTGTGGTGATAAGCTGACTCTGGATCAGTTAAAGATGAGGTGTGACTCCCTCATGCTCTGAGTGGTGAGGCTTCAAGCCT
TAAAGTCAGTGTGCCCTCAACCAGCACAGCCTGCCCCAATTCCCCCAGCCCCTGCTCCAGCAGCTGTCATCTCTGGGTGCCACCATCGGT
CTGGCTGCAGCTAGAGGACAGGCAAGCCAGCTCTGGGGGAGTCTTAGGAACTGGGAGTTGGTCTTCACTCAGATGCCTCATCTTGCCTTT
CCCAGGGCCTTAAAATTACATCCTTCACTGTGTGGACCTAGAGACTCCAACTTGAATTCCTAGTAACTTTCTTGGTATGCTGGCCAGAAA
GGGAAATGAGGAGGAGAGTAGAAACCACAGCTCTTAGTAGTAATGGCATACAGTCTAGAGGACCATTCATGCAATGACTATTTCTAAAGC
ACCTGCTACACAGCAGGCTGTACACAGCAGATCAGTACTGTTCAACAGAACTTCCTGAGATGATGGAAATGTTCTACCTCTGCACTCACT
GTCCAGTACATTAGACACTAGGCACATTGGCTGTTAATCACTTGGAATGTGTTTAGCTTGACTGAGGAATTAAATTTTGATTGTAAATTT
AAATCGCCACACATGGCTAGTGGCTACTGTATTGGAGTGCACAGCTCTAGATGGCTCCTAGATTATTGAGAGCCTTCAAAACAAATCAAC
CTAGTTCTATAGATGAAGACATAAAAGACACTGGTAAACACCAAGGTAAAAGGGCCCCCAAGGTGGTCATGACTGGTCTCATTTGCAGAA

>75361_75361_2_ROR1-IL12RB2_ROR1_chr1_64475048_ENST00000371079_IL12RB2_chr1_67787285_ENST00000371000_length(amino acids)=701AA_BP=67
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDACKRGDVTVKPSHVILLGSTVN
ITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCKLACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQ
GTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPW
DIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPE
EEPTGMLDVWYMKRHIDYSRQQISLFWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGSSLP
TRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALISENIKSYICYEIR
VYALSGDQGGCSSILGNSKHKAPLSGPHINAITEEKGSILISWNSIPVQEQMGCLLHYRIYWKERDSNSQPQLCEIPYRVSQNSHPINSL

--------------------------------------------------------------
>75361_75361_3_ROR1-IL12RB2_ROR1_chr1_64475048_ENST00000371079_IL12RB2_chr1_67787285_ENST00000541374_length(transcript)=2697nt_BP=538nt
GAGCTGGAGCAGCCGCCACCGCCGCCGCCGAGGGAGCCCCGGGACGGCAGCCCCTGGGCGCAGGGTGCGCTGTTCTCGGAGTCCGACCCA
GGGCGACTCACGCCCACTGGTGCGACCCGGACAGCCTGGGACTGACCCGCCGGCCCAGGCGAGGCTGCAGCCAGAGGGCTGGGAAGGGAT
CGCGCTCGCGGCATCCAGAGGCGGCCAGGCGGAGGCGAGGGAGCAGGTTAGAGGGACAAAGAGCTTTGCAGACGTCCCCGGCGTCCTGCG
AGCGCCAGCGGCCGGGACGAGGCGGCCGGGAGCCCGGGAAGAGCCCGTGGATGTTCTGCGCGCGGCCTGGGAGCCGCCGCCGCCGCCGCC
TCAGCGAGAGGAGGAATGCACCGGCCGCGCCGCCGCGGGACGCGCCCGCCGCTCCTGGCGCTGCTGGCCGCGCTGCTGCTGGCCGCACGC
GGGGCTGCTGCCCAAGAAACAGAGCTGTCAGTCAGTGCTGAATTAGTGCCTACCTCATCATGGAACATCTCAAGTGAACTCAACAAAGAT
GCGTGCAAGAGAGGCGATGTGACTGTGAAGCCTTCCCATGTAATTTTACTTGGATCCACTGTCAATATTACATGCTCTTTGAAGCCCAGA
CAAGGCTGCTTTCACTATTCCAGACGTAACAAGTTAATCCTGTACAAGTTTGACAGAAGAATCAATTTTCACCATGGCCACTCCCTCAAT
TCTCAAGTCACAGGTCTTCCCCTTGGTACAACCTTGTTTGTCTGCAAACTGGCCTGTATCAATAGTGATGAAATTCAAATATGTGGAGCA
GAGATCTTCGTTGGTGTTGCTCCAGAACAGCCTCAAAATTTATCCTGCATACAGAAGGGAGAACAGGGGACTGTGGCCTGCACCTGGGAA
AGAGGACGAGACACCCACTTATACACTGAGTATACTCTACAGCTAAGTGGACCAAAAAATTTAACCTGGCAGAAGCAATGTAAAGACATT
TATTGTGACTATTTGGACTTTGGAATCAACCTCACCCCTGAATCACCTGAATCCAATTTCACAGCCAAGGTTACTGCTGTCAATAGTCTT
GGAAGCTCCTCTTCACTTCCATCCACATTCACATTCTTGGACATAGTGAGGCCTCTTCCTCCGTGGGACATTAGAATCAAATTTCAAAAG
GCTTCTGTGAGCAGATGTACCCTTTATTGGAGAGATGAGGGACTGGTACTGCTTAATCGACTCAGATATCGGCCCAGTAACAGCAGGCTC
TGGAATATGGTTAATGTTACAAAGGCCAAAGGAAGACATGATTTGCTGGATCTGAAACCATTTACAGAATATGAATTTCAGATTTCCTCT
AAGCTACATCTTTATAAGGGAAGTTGGAGTGATTGGAGTGAATCATTGAGAGCACAAACACCAGAAGAAGAGCCTACTGGGATGTTAGAT
GTCTGGTACATGAAACGGCACATTGACTACAGTAGACAACAGATTTCTCTTTTCTGGAAGAATCTGAGTGTCTCAGAGGCAAGAGGAAAA
ATTCTCCACTATCAGGTGACCTTGCAGGAGCTGACAGGAGGGAAAGCCATGACACAGAACATCACAGGACACACCTCCTGGACCACAGTC
ATTCCTAGAACCGGAAATTGGGCTGTGGCTGTGTCTGCAGCAAATTCAAAAGGCAGTTCTCTGCCCACTCGTATTAACATAATGAACCTG
TGTGAGGCAGGGTTGCTGGCTCCTCGCCAGGTCTCTGCAAACTCAGAGGGCATGGACAACATTCTGGTGACTTGGCAGCCTCCCAGGAAA
GATCCCTCTGCTGTTCAGGAGTACGTGGTGGAATGGAGAGAGCTCCATCCAGGGGGTGACACACAGGTCCCTCTAAACTGGCTACGGAGT
CGACCCTACAATGTGTCTGCTCTGATTTCAGAGAACATAAAATCCTACATCTGTTATGAAATCCGTGTGTATGCACTCTCAGGGGATCAA
GGAGGATGCAGCTCCATCCTGGGTAACTCTAAGCACAAAGCACCACTGAGTGGCCCCCACATTAATGCCATCACAGAGGAAAAGGGGAGC
ATTTTAATTTCATGGAACAGCATTCCAGTCCAGGAGCAAATGGGCTGCCTCCTCCATTATAGGATATACTGGAAGGAACGGGACTCCAAC
TCCCAGCCTCAGCTCTGTGAAATTCCCTACAGAGTCTCCCAAAATTCACATCCAATAAACAGCCTGCAGCCCCGAGTGACATATGTCCTG
TGGATGACAGCTCTGACAGCTGCTGGTGAAAGTTCCCACGGAAATGAGAGGGAATTTTGTCTGCAAGGTAAAGCCAATTGGATGGCGTTT
GTGGCACCAAGCATTTGCATTGCTATCATCATGGTGGGCATTTTCTCAACGCATTACTTCCAGCAAAAGAGAAGACACAGCTGCCCTTGG
ACAGGCTCCTGATAGACTGGCCCACGCCTGAAGATCCTGAACCGCTGGTCATCAGTGAAGTCCTTCATCAAGTGACCCCAGTTTTCAGAC
ATCCCCCCTGCTCCAACTGGCCACAAAGGGAAAAAGGAATCCAAGGTCATCAGGCCTCTGAGAAAGACATGATGCACAGTGCCTCAAGCC

>75361_75361_3_ROR1-IL12RB2_ROR1_chr1_64475048_ENST00000371079_IL12RB2_chr1_67787285_ENST00000541374_length(amino acids)=701AA_BP=67
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDACKRGDVTVKPSHVILLGSTVN
ITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCKLACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQ
GTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPW
DIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPE
EEPTGMLDVWYMKRHIDYSRQQISLFWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGSSLP
TRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALISENIKSYICYEIR
VYALSGDQGGCSSILGNSKHKAPLSGPHINAITEEKGSILISWNSIPVQEQMGCLLHYRIYWKERDSNSQPQLCEIPYRVSQNSHPINSL

--------------------------------------------------------------
>75361_75361_4_ROR1-IL12RB2_ROR1_chr1_64475048_ENST00000371079_IL12RB2_chr1_67787285_ENST00000544434_length(transcript)=2851nt_BP=538nt
GAGCTGGAGCAGCCGCCACCGCCGCCGCCGAGGGAGCCCCGGGACGGCAGCCCCTGGGCGCAGGGTGCGCTGTTCTCGGAGTCCGACCCA
GGGCGACTCACGCCCACTGGTGCGACCCGGACAGCCTGGGACTGACCCGCCGGCCCAGGCGAGGCTGCAGCCAGAGGGCTGGGAAGGGAT
CGCGCTCGCGGCATCCAGAGGCGGCCAGGCGGAGGCGAGGGAGCAGGTTAGAGGGACAAAGAGCTTTGCAGACGTCCCCGGCGTCCTGCG
AGCGCCAGCGGCCGGGACGAGGCGGCCGGGAGCCCGGGAAGAGCCCGTGGATGTTCTGCGCGCGGCCTGGGAGCCGCCGCCGCCGCCGCC
TCAGCGAGAGGAGGAATGCACCGGCCGCGCCGCCGCGGGACGCGCCCGCCGCTCCTGGCGCTGCTGGCCGCGCTGCTGCTGGCCGCACGC
GGGGCTGCTGCCCAAGAAACAGAGCTGTCAGTCAGTGCTGAATTAGTGCCTACCTCATCATGGAACATCTCAAGTGAACTCAACAAAGAT
GCGTGCAAGAGAGGCGATGTGACTGTGAAGCCTTCCCATGTAATTTTACTTGGATCCACTGTCAATATTACATGCTCTTTGAAGCCCAGA
CAAGGCTGCTTTCACTATTCCAGACGTAACAAGTTAATCCTGTACAAGTTTGACAGAAGAATCAATTTTCACCATGGCCACTCCCTCAAT
TCTCAAGTCACAGGTCTTCCCCTTGGTACAACCTTGTTTGTCTGCAAACTGGCCTGTATCAATAGTGATGAAATTCAAATATGTGGAGCA
GAGATCTTCGTTGGTGTTGCTCCAGAACAGCCTCAAAATTTATCCTGCATACAGAAGGGAGAACAGGGGACTGTGGCCTGCACCTGGGAA
AGAGGACGAGACACCCACTTATACACTGAGTATACTCTACAGCTAAGTGGACCAAAAAATTTAACCTGGCAGAAGCAATGTAAAGACATT
TATTGTGACTATTTGGACTTTGGAATCAACCTCACCCCTGAATCACCTGAATCCAATTTCACAGCCAAGGTTACTGCTGTCAATAGTCTT
GGAAGCTCCTCTTCACTTCCATCCACATTCACATTCTTGGACATAGTGAGGCCTCTTCCTCCGTGGGACATTAGAATCAAATTTCAAAAG
GCTTCTGTGAGCAGATGTACCCTTTATTGGAGAGATGAGGGACTGGTACTGCTTAATCGACTCAGATATCGGCCCAGTAACAGCAGGCTC
TGGAATATGGTTAATGTTACAAAGGCCAAAGGAAGACATGATTTGCTGGATCTGAAACCATTTACAGAATATGAATTTCAGATTTCCTCT
AAGCTACATCTTTATAAGGGAAGTTGGAGTGATTGGAGTGAATCATTGAGAGCACAAACACCAGAAGAAGAGCCTACTGGGATGTTAGAT
GTCTGGTACATGAAACGGCACATTGACTACAGTAGACAACAGATTTCTCTTTTCTGGAAGAATCTGAGTGTCTCAGAGGCAAGAGGAAAA
ATTCTCCACTATCAGGTGACCTTGCAGGAGCTGACAGGAGGGAAAGCCATGACACAGAACATCACAGGACACACCTCCTGGACCACAGTC
ATTCCTAGAACCGGAAATTGGGCTGTGGCTGTGTCTGCAGCAAATTCAAAAGGCAGTTCTCTGCCCACTCGTATTAACATAATGAACCTG
TGTGAGGCAGGGTTGCTGGCTCCTCGCCAGGTCTCTGCAAACTCAGAGGGCATGGACAACATTCTGGTGACTTGGCAGCCTCCCAGGAAA
GATCCCTCTGCTGTTCAGGAGTACGTGGTGGAATGGAGAGAGCTCCATCCAGGGGGTGACACACAGGTCCCTCTAAACTGGCTACGGAGT
CGACCCTACAATGTGTCTGCTCTGATTTCAGAAATTCCCTACAGAGTCTCCCAAAATTCACATCCAATAAACAGCCTGCAGCCCCGAGTG
ACATATGTCCTGTGGATGACAGCTCTGACAGCTGCTGGTGAAAGTTCCCACGGAAATGAGAGGGAATTTTGTCTGCAAGGTAAAGCCAAT
TGGATGGCGTTTGTGGCACCAAGCATTTGCATTGCTATCATCATGGTGGGCATTTTCTCAACGCATTACTTCCAGCAAAAGGTGTTTGTT
CTCCTAGCAGCCCTCAGACCTCAGTGGTGTAGCAGAGAAATTCCAGATCCAGCAAATAGCACTTGCGCTAAGAAATATCCCATTGCAGAG
GAGAAGACACAGCTGCCCTTGGACAGGCTCCTGATAGACTGGCCCACGCCTGAAGATCCTGAACCGCTGGTCATCAGTGAAGTCCTTCAT
CAAGTGACCCCAGTTTTCAGACATCCCCCCTGCTCCAACTGGCCACAAAGGGAAAAAGGAATCCAAGGTCATCAGGCCTCTGAGAAAGAC
ATGATGCACAGTGCCTCAAGCCCACCACCTCCAAGAGCTCTCCAAGCTGAGAGCAGACAACTGGTGGATCTGTACAAGGTGCTGGAGAGC
AGGGGCTCCGACCCAAAGCCCGAAAACCCAGCCTGTCCCTGGACGGTGCTCCCAGCAGGTGACCTTCCCACCCATGATGGCTACTTACCC
TCCAACATAGATGACCTCCCCTCACATGAGGCACCTCTCGCTGACTCTCTGGAAGAACTGGAGCCTCAGCACATCTCCCTTTCTGTTTTC
CCCTCAAGTTCTCTTCACCCACTCACCTTCTCCTGTGGTGATAAGCTGACTCTGGATCAGTTAAAGATGAGGTGTGACTCCCTCATGCTC

>75361_75361_4_ROR1-IL12RB2_ROR1_chr1_64475048_ENST00000371079_IL12RB2_chr1_67787285_ENST00000544434_length(amino acids)=818AA_BP=67
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDACKRGDVTVKPSHVILLGSTVN
ITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCKLACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQ
GTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPW
DIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPE
EEPTGMLDVWYMKRHIDYSRQQISLFWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGSSLP
TRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALISEIPYRVSQNSHP
INSLQPRVTYVLWMTALTAAGESSHGNEREFCLQGKANWMAFVAPSICIAIIMVGIFSTHYFQQKVFVLLAALRPQWCSREIPDPANSTC
AKKYPIAEEKTQLPLDRLLIDWPTPEDPEPLVISEVLHQVTPVFRHPPCSNWPQREKGIQGHQASEKDMMHSASSPPPPRALQAESRQLV
DLYKVLESRGSDPKPENPACPWTVLPAGDLPTHDGYLPSNIDDLPSHEAPLADSLEELEPQHISLSVFPSSSLHPLTFSCGDKLTLDQLK

--------------------------------------------------------------
>75361_75361_5_ROR1-IL12RB2_ROR1_chr1_64475048_ENST00000371080_IL12RB2_chr1_67787285_ENST00000262345_length(transcript)=3883nt_BP=559nt
GAGCGAGAGAGGGAGCGTGGAGAGCTGGAGCAGCCGCCACCGCCGCCGCCGAGGGAGCCCCGGGACGGCAGCCCCTGGGCGCAGGGTGCG
CTGTTCTCGGAGTCCGACCCAGGGCGACTCACGCCCACTGGTGCGACCCGGACAGCCTGGGACTGACCCGCCGGCCCAGGCGAGGCTGCA
GCCAGAGGGCTGGGAAGGGATCGCGCTCGCGGCATCCAGAGGCGGCCAGGCGGAGGCGAGGGAGCAGGTTAGAGGGACAAAGAGCTTTGC
AGACGTCCCCGGCGTCCTGCGAGCGCCAGCGGCCGGGACGAGGCGGCCGGGAGCCCGGGAAGAGCCCGTGGATGTTCTGCGCGCGGCCTG
GGAGCCGCCGCCGCCGCCGCCTCAGCGAGAGGAGGAATGCACCGGCCGCGCCGCCGCGGGACGCGCCCGCCGCTCCTGGCGCTGCTGGCC
GCGCTGCTGCTGGCCGCACGCGGGGCTGCTGCCCAAGAAACAGAGCTGTCAGTCAGTGCTGAATTAGTGCCTACCTCATCATGGAACATC
TCAAGTGAACTCAACAAAGATGCGTGCAAGAGAGGCGATGTGACTGTGAAGCCTTCCCATGTAATTTTACTTGGATCCACTGTCAATATT
ACATGCTCTTTGAAGCCCAGACAAGGCTGCTTTCACTATTCCAGACGTAACAAGTTAATCCTGTACAAGTTTGACAGAAGAATCAATTTT
CACCATGGCCACTCCCTCAATTCTCAAGTCACAGGTCTTCCCCTTGGTACAACCTTGTTTGTCTGCAAACTGGCCTGTATCAATAGTGAT
GAAATTCAAATATGTGGAGCAGAGATCTTCGTTGGTGTTGCTCCAGAACAGCCTCAAAATTTATCCTGCATACAGAAGGGAGAACAGGGG
ACTGTGGCCTGCACCTGGGAAAGAGGACGAGACACCCACTTATACACTGAGTATACTCTACAGCTAAGTGGACCAAAAAATTTAACCTGG
CAGAAGCAATGTAAAGACATTTATTGTGACTATTTGGACTTTGGAATCAACCTCACCCCTGAATCACCTGAATCCAATTTCACAGCCAAG
GTTACTGCTGTCAATAGTCTTGGAAGCTCCTCTTCACTTCCATCCACATTCACATTCTTGGACATAGTGAGGCCTCTTCCTCCGTGGGAC
ATTAGAATCAAATTTCAAAAGGCTTCTGTGAGCAGATGTACCCTTTATTGGAGAGATGAGGGACTGGTACTGCTTAATCGACTCAGATAT
CGGCCCAGTAACAGCAGGCTCTGGAATATGGTTAATGTTACAAAGGCCAAAGGAAGACATGATTTGCTGGATCTGAAACCATTTACAGAA
TATGAATTTCAGATTTCCTCTAAGCTACATCTTTATAAGGGAAGTTGGAGTGATTGGAGTGAATCATTGAGAGCACAAACACCAGAAGAA
GAGCCTACTGGGATGTTAGATGTCTGGTACATGAAACGGCACATTGACTACAGTAGACAACAGATTTCTCTTTTCTGGAAGAATCTGAGT
GTCTCAGAGGCAAGAGGAAAAATTCTCCACTATCAGGTGACCTTGCAGGAGCTGACAGGAGGGAAAGCCATGACACAGAACATCACAGGA
CACACCTCCTGGACCACAGTCATTCCTAGAACCGGAAATTGGGCTGTGGCTGTGTCTGCAGCAAATTCAAAAGGCAGTTCTCTGCCCACT
CGTATTAACATAATGAACCTGTGTGAGGCAGGGTTGCTGGCTCCTCGCCAGGTCTCTGCAAACTCAGAGGGCATGGACAACATTCTGGTG
ACTTGGCAGCCTCCCAGGAAAGATCCCTCTGCTGTTCAGGAGTACGTGGTGGAATGGAGAGAGCTCCATCCAGGGGGTGACACACAGGTC
CCTCTAAACTGGCTACGGAGTCGACCCTACAATGTGTCTGCTCTGATTTCAGAGAACATAAAATCCTACATCTGTTATGAAATCCGTGTG
TATGCACTCTCAGGGGATCAAGGAGGATGCAGCTCCATCCTGGGTAACTCTAAGCACAAAGCACCACTGAGTGGCCCCCACATTAATGCC
ATCACAGAGGAAAAGGGGAGCATTTTAATTTCATGGAACAGCATTCCAGTCCAGGAGCAAATGGGCTGCCTCCTCCATTATAGGATATAC
TGGAAGGAACGGGACTCCAACTCCCAGCCTCAGCTCTGTGAAATTCCCTACAGAGTCTCCCAAAATTCACATCCAATAAACAGCCTGCAG
CCCCGAGTGACATATGTCCTGTGGATGACAGCTCTGACAGCTGCTGGTGAAAGTTCCCACGGAAATGAGAGGGAATTTTGTCTGCAAGGT
AAAGCCAATTGGATGGCGTTTGTGGCACCAAGCATTTGCATTGCTATCATCATGGTGGGCATTTTCTCAACGCATTACTTCCAGCAAAAG
GTGTTTGTTCTCCTAGCAGCCCTCAGACCTCAGTGGTGTAGCAGAGAAATTCCAGATCCAGCAAATAGCACTTGCGCTAAGAAATATCCC
ATTGCAGAGGAGAAGACACAGCTGCCCTTGGACAGGCTCCTGATAGACTGGCCCACGCCTGAAGATCCTGAACCGCTGGTCATCAGTGAA
GTCCTTCATCAAGTGACCCCAGTTTTCAGACATCCCCCCTGCTCCAACTGGCCACAAAGGGAAAAAGGAATCCAAGGTCATCAGGCCTCT
GAGAAAGACATGATGCACAGTGCCTCAAGCCCACCACCTCCAAGAGCTCTCCAAGCTGAGAGCAGACAACTGGTGGATCTGTACAAGGTG
CTGGAGAGCAGGGGCTCCGACCCAAAGCCCGAAAACCCAGCCTGTCCCTGGACGGTGCTCCCAGCAGGTGACCTTCCCACCCATGATGGC
TACTTACCCTCCAACATAGATGACCTCCCCTCACATGAGGCACCTCTCGCTGACTCTCTGGAAGAACTGGAGCCTCAGCACATCTCCCTT
TCTGTTTTCCCCTCAAGTTCTCTTCACCCACTCACCTTCTCCTGTGGTGATAAGCTGACTCTGGATCAGTTAAAGATGAGGTGTGACTCC
CTCATGCTCTGAGTGGTGAGGCTTCAAGCCTTAAAGTCAGTGTGCCCTCAACCAGCACAGCCTGCCCCAATTCCCCCAGCCCCTGCTCCA
GCAGCTGTCATCTCTGGGTGCCACCATCGGTCTGGCTGCAGCTAGAGGACAGGCAAGCCAGCTCTGGGGGAGTCTTAGGAACTGGGAGTT
GGTCTTCACTCAGATGCCTCATCTTGCCTTTCCCAGGGCCTTAAAATTACATCCTTCACTGTGTGGACCTAGAGACTCCAACTTGAATTC
CTAGTAACTTTCTTGGTATGCTGGCCAGAAAGGGAAATGAGGAGGAGAGTAGAAACCACAGCTCTTAGTAGTAATGGCATACAGTCTAGA
GGACCATTCATGCAATGACTATTTCTAAAGCACCTGCTACACAGCAGGCTGTACACAGCAGATCAGTACTGTTCAACAGAACTTCCTGAG
ATGATGGAAATGTTCTACCTCTGCACTCACTGTCCAGTACATTAGACACTAGGCACATTGGCTGTTAATCACTTGGAATGTGTTTAGCTT
GACTGAGGAATTAAATTTTGATTGTAAATTTAAATCGCCACACATGGCTAGTGGCTACTGTATTGGAGTGCACAGCTCTAGATGGCTCCT
AGATTATTGAGAGCCTTCAAAACAAATCAACCTAGTTCTATAGATGAAGACATAAAAGACACTGGTAAACACCAAGGTAAAAGGGCCCCC
AAGGTGGTCATGACTGGTCTCATTTGCAGAAGTCTAAGAATGTACCTTTTTCTGGCCGGGCGTGGTAGCTCATGCCTGTAATCCCAGCAC

>75361_75361_5_ROR1-IL12RB2_ROR1_chr1_64475048_ENST00000371080_IL12RB2_chr1_67787285_ENST00000262345_length(amino acids)=904AA_BP=67
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDACKRGDVTVKPSHVILLGSTVN
ITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCKLACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQ
GTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPW
DIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPE
EEPTGMLDVWYMKRHIDYSRQQISLFWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGSSLP
TRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALISENIKSYICYEIR
VYALSGDQGGCSSILGNSKHKAPLSGPHINAITEEKGSILISWNSIPVQEQMGCLLHYRIYWKERDSNSQPQLCEIPYRVSQNSHPINSL
QPRVTYVLWMTALTAAGESSHGNEREFCLQGKANWMAFVAPSICIAIIMVGIFSTHYFQQKVFVLLAALRPQWCSREIPDPANSTCAKKY
PIAEEKTQLPLDRLLIDWPTPEDPEPLVISEVLHQVTPVFRHPPCSNWPQREKGIQGHQASEKDMMHSASSPPPPRALQAESRQLVDLYK
VLESRGSDPKPENPACPWTVLPAGDLPTHDGYLPSNIDDLPSHEAPLADSLEELEPQHISLSVFPSSSLHPLTFSCGDKLTLDQLKMRCD

--------------------------------------------------------------
>75361_75361_6_ROR1-IL12RB2_ROR1_chr1_64475048_ENST00000371080_IL12RB2_chr1_67787285_ENST00000371000_length(transcript)=3783nt_BP=559nt
GAGCGAGAGAGGGAGCGTGGAGAGCTGGAGCAGCCGCCACCGCCGCCGCCGAGGGAGCCCCGGGACGGCAGCCCCTGGGCGCAGGGTGCG
CTGTTCTCGGAGTCCGACCCAGGGCGACTCACGCCCACTGGTGCGACCCGGACAGCCTGGGACTGACCCGCCGGCCCAGGCGAGGCTGCA
GCCAGAGGGCTGGGAAGGGATCGCGCTCGCGGCATCCAGAGGCGGCCAGGCGGAGGCGAGGGAGCAGGTTAGAGGGACAAAGAGCTTTGC
AGACGTCCCCGGCGTCCTGCGAGCGCCAGCGGCCGGGACGAGGCGGCCGGGAGCCCGGGAAGAGCCCGTGGATGTTCTGCGCGCGGCCTG
GGAGCCGCCGCCGCCGCCGCCTCAGCGAGAGGAGGAATGCACCGGCCGCGCCGCCGCGGGACGCGCCCGCCGCTCCTGGCGCTGCTGGCC
GCGCTGCTGCTGGCCGCACGCGGGGCTGCTGCCCAAGAAACAGAGCTGTCAGTCAGTGCTGAATTAGTGCCTACCTCATCATGGAACATC
TCAAGTGAACTCAACAAAGATGCGTGCAAGAGAGGCGATGTGACTGTGAAGCCTTCCCATGTAATTTTACTTGGATCCACTGTCAATATT
ACATGCTCTTTGAAGCCCAGACAAGGCTGCTTTCACTATTCCAGACGTAACAAGTTAATCCTGTACAAGTTTGACAGAAGAATCAATTTT
CACCATGGCCACTCCCTCAATTCTCAAGTCACAGGTCTTCCCCTTGGTACAACCTTGTTTGTCTGCAAACTGGCCTGTATCAATAGTGAT
GAAATTCAAATATGTGGAGCAGAGATCTTCGTTGGTGTTGCTCCAGAACAGCCTCAAAATTTATCCTGCATACAGAAGGGAGAACAGGGG
ACTGTGGCCTGCACCTGGGAAAGAGGACGAGACACCCACTTATACACTGAGTATACTCTACAGCTAAGTGGACCAAAAAATTTAACCTGG
CAGAAGCAATGTAAAGACATTTATTGTGACTATTTGGACTTTGGAATCAACCTCACCCCTGAATCACCTGAATCCAATTTCACAGCCAAG
GTTACTGCTGTCAATAGTCTTGGAAGCTCCTCTTCACTTCCATCCACATTCACATTCTTGGACATAGTGAGGCCTCTTCCTCCGTGGGAC
ATTAGAATCAAATTTCAAAAGGCTTCTGTGAGCAGATGTACCCTTTATTGGAGAGATGAGGGACTGGTACTGCTTAATCGACTCAGATAT
CGGCCCAGTAACAGCAGGCTCTGGAATATGGTTAATGTTACAAAGGCCAAAGGAAGACATGATTTGCTGGATCTGAAACCATTTACAGAA
TATGAATTTCAGATTTCCTCTAAGCTACATCTTTATAAGGGAAGTTGGAGTGATTGGAGTGAATCATTGAGAGCACAAACACCAGAAGAA
GAGCCTACTGGGATGTTAGATGTCTGGTACATGAAACGGCACATTGACTACAGTAGACAACAGATTTCTCTTTTCTGGAAGAATCTGAGT
GTCTCAGAGGCAAGAGGAAAAATTCTCCACTATCAGGTGACCTTGCAGGAGCTGACAGGAGGGAAAGCCATGACACAGAACATCACAGGA
CACACCTCCTGGACCACAGTCATTCCTAGAACCGGAAATTGGGCTGTGGCTGTGTCTGCAGCAAATTCAAAAGGCAGTTCTCTGCCCACT
CGTATTAACATAATGAACCTGTGTGAGGCAGGGTTGCTGGCTCCTCGCCAGGTCTCTGCAAACTCAGAGGGCATGGACAACATTCTGGTG
ACTTGGCAGCCTCCCAGGAAAGATCCCTCTGCTGTTCAGGAGTACGTGGTGGAATGGAGAGAGCTCCATCCAGGGGGTGACACACAGGTC
CCTCTAAACTGGCTACGGAGTCGACCCTACAATGTGTCTGCTCTGATTTCAGAGAACATAAAATCCTACATCTGTTATGAAATCCGTGTG
TATGCACTCTCAGGGGATCAAGGAGGATGCAGCTCCATCCTGGGTAACTCTAAGCACAAAGCACCACTGAGTGGCCCCCACATTAATGCC
ATCACAGAGGAAAAGGGGAGCATTTTAATTTCATGGAACAGCATTCCAGTCCAGGAGCAAATGGGCTGCCTCCTCCATTATAGGATATAC
TGGAAGGAACGGGACTCCAACTCCCAGCCTCAGCTCTGTGAAATTCCCTACAGAGTCTCCCAAAATTCACATCCAATAAACAGCCTGCAG
CCCCGAGTGACATATGTCCTGTGGATGACAGCTCTGACAGCTGCTGGTGAAAGTTCCCACGGAAATGAGAGGGAATTTTGTCTGCAAGGT
AAAGCCAATTGGATGGCGTTTGTGGCACCAAGCATTTGCATTGCTATCATCATGGTGGGCATTTTCTCAACGCATTACTTCCAGCAAAAG
AGAAGACACAGCTGCCCTTGGACAGGCTCCTGATAGACTGGCCCACGCCTGAAGATCCTGAACCGCTGGTCATCAGTGAAGTCCTTCATC
AAGTGACCCCAGTTTTCAGACATCCCCCCTGCTCCAACTGGCCACAAAGGGAAAAAGGAATCCAAGGTCATCAGGCCTCTGAGAAAGACA
TGATGCACAGTGCCTCAAGCCCACCACCTCCAAGAGCTCTCCAAGCTGAGAGCAGACAACTGGTGGATCTGTACAAGGTGCTGGAGAGCA
GGGGCTCCGACCCAAAGCCCGAAAACCCAGCCTGTCCCTGGACGGTGCTCCCAGCAGGTGACCTTCCCACCCATGATGGCTACTTACCCT
CCAACATAGATGACCTCCCCTCACATGAGGCACCTCTCGCTGACTCTCTGGAAGAACTGGAGCCTCAGCACATCTCCCTTTCTGTTTTCC
CCTCAAGTTCTCTTCACCCACTCACCTTCTCCTGTGGTGATAAGCTGACTCTGGATCAGTTAAAGATGAGGTGTGACTCCCTCATGCTCT
GAGTGGTGAGGCTTCAAGCCTTAAAGTCAGTGTGCCCTCAACCAGCACAGCCTGCCCCAATTCCCCCAGCCCCTGCTCCAGCAGCTGTCA
TCTCTGGGTGCCACCATCGGTCTGGCTGCAGCTAGAGGACAGGCAAGCCAGCTCTGGGGGAGTCTTAGGAACTGGGAGTTGGTCTTCACT
CAGATGCCTCATCTTGCCTTTCCCAGGGCCTTAAAATTACATCCTTCACTGTGTGGACCTAGAGACTCCAACTTGAATTCCTAGTAACTT
TCTTGGTATGCTGGCCAGAAAGGGAAATGAGGAGGAGAGTAGAAACCACAGCTCTTAGTAGTAATGGCATACAGTCTAGAGGACCATTCA
TGCAATGACTATTTCTAAAGCACCTGCTACACAGCAGGCTGTACACAGCAGATCAGTACTGTTCAACAGAACTTCCTGAGATGATGGAAA
TGTTCTACCTCTGCACTCACTGTCCAGTACATTAGACACTAGGCACATTGGCTGTTAATCACTTGGAATGTGTTTAGCTTGACTGAGGAA
TTAAATTTTGATTGTAAATTTAAATCGCCACACATGGCTAGTGGCTACTGTATTGGAGTGCACAGCTCTAGATGGCTCCTAGATTATTGA
GAGCCTTCAAAACAAATCAACCTAGTTCTATAGATGAAGACATAAAAGACACTGGTAAACACCAAGGTAAAAGGGCCCCCAAGGTGGTCA
TGACTGGTCTCATTTGCAGAAGTCTAAGAATGTACCTTTTTCTGGCCGGGCGTGGTAGCTCATGCCTGTAATCCCAGCACTTTGGGAGGC

>75361_75361_6_ROR1-IL12RB2_ROR1_chr1_64475048_ENST00000371080_IL12RB2_chr1_67787285_ENST00000371000_length(amino acids)=701AA_BP=67
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDACKRGDVTVKPSHVILLGSTVN
ITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCKLACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQ
GTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPW
DIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPE
EEPTGMLDVWYMKRHIDYSRQQISLFWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGSSLP
TRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALISENIKSYICYEIR
VYALSGDQGGCSSILGNSKHKAPLSGPHINAITEEKGSILISWNSIPVQEQMGCLLHYRIYWKERDSNSQPQLCEIPYRVSQNSHPINSL

--------------------------------------------------------------
>75361_75361_7_ROR1-IL12RB2_ROR1_chr1_64475048_ENST00000371080_IL12RB2_chr1_67787285_ENST00000541374_length(transcript)=2718nt_BP=559nt
GAGCGAGAGAGGGAGCGTGGAGAGCTGGAGCAGCCGCCACCGCCGCCGCCGAGGGAGCCCCGGGACGGCAGCCCCTGGGCGCAGGGTGCG
CTGTTCTCGGAGTCCGACCCAGGGCGACTCACGCCCACTGGTGCGACCCGGACAGCCTGGGACTGACCCGCCGGCCCAGGCGAGGCTGCA
GCCAGAGGGCTGGGAAGGGATCGCGCTCGCGGCATCCAGAGGCGGCCAGGCGGAGGCGAGGGAGCAGGTTAGAGGGACAAAGAGCTTTGC
AGACGTCCCCGGCGTCCTGCGAGCGCCAGCGGCCGGGACGAGGCGGCCGGGAGCCCGGGAAGAGCCCGTGGATGTTCTGCGCGCGGCCTG
GGAGCCGCCGCCGCCGCCGCCTCAGCGAGAGGAGGAATGCACCGGCCGCGCCGCCGCGGGACGCGCCCGCCGCTCCTGGCGCTGCTGGCC
GCGCTGCTGCTGGCCGCACGCGGGGCTGCTGCCCAAGAAACAGAGCTGTCAGTCAGTGCTGAATTAGTGCCTACCTCATCATGGAACATC
TCAAGTGAACTCAACAAAGATGCGTGCAAGAGAGGCGATGTGACTGTGAAGCCTTCCCATGTAATTTTACTTGGATCCACTGTCAATATT
ACATGCTCTTTGAAGCCCAGACAAGGCTGCTTTCACTATTCCAGACGTAACAAGTTAATCCTGTACAAGTTTGACAGAAGAATCAATTTT
CACCATGGCCACTCCCTCAATTCTCAAGTCACAGGTCTTCCCCTTGGTACAACCTTGTTTGTCTGCAAACTGGCCTGTATCAATAGTGAT
GAAATTCAAATATGTGGAGCAGAGATCTTCGTTGGTGTTGCTCCAGAACAGCCTCAAAATTTATCCTGCATACAGAAGGGAGAACAGGGG
ACTGTGGCCTGCACCTGGGAAAGAGGACGAGACACCCACTTATACACTGAGTATACTCTACAGCTAAGTGGACCAAAAAATTTAACCTGG
CAGAAGCAATGTAAAGACATTTATTGTGACTATTTGGACTTTGGAATCAACCTCACCCCTGAATCACCTGAATCCAATTTCACAGCCAAG
GTTACTGCTGTCAATAGTCTTGGAAGCTCCTCTTCACTTCCATCCACATTCACATTCTTGGACATAGTGAGGCCTCTTCCTCCGTGGGAC
ATTAGAATCAAATTTCAAAAGGCTTCTGTGAGCAGATGTACCCTTTATTGGAGAGATGAGGGACTGGTACTGCTTAATCGACTCAGATAT
CGGCCCAGTAACAGCAGGCTCTGGAATATGGTTAATGTTACAAAGGCCAAAGGAAGACATGATTTGCTGGATCTGAAACCATTTACAGAA
TATGAATTTCAGATTTCCTCTAAGCTACATCTTTATAAGGGAAGTTGGAGTGATTGGAGTGAATCATTGAGAGCACAAACACCAGAAGAA
GAGCCTACTGGGATGTTAGATGTCTGGTACATGAAACGGCACATTGACTACAGTAGACAACAGATTTCTCTTTTCTGGAAGAATCTGAGT
GTCTCAGAGGCAAGAGGAAAAATTCTCCACTATCAGGTGACCTTGCAGGAGCTGACAGGAGGGAAAGCCATGACACAGAACATCACAGGA
CACACCTCCTGGACCACAGTCATTCCTAGAACCGGAAATTGGGCTGTGGCTGTGTCTGCAGCAAATTCAAAAGGCAGTTCTCTGCCCACT
CGTATTAACATAATGAACCTGTGTGAGGCAGGGTTGCTGGCTCCTCGCCAGGTCTCTGCAAACTCAGAGGGCATGGACAACATTCTGGTG
ACTTGGCAGCCTCCCAGGAAAGATCCCTCTGCTGTTCAGGAGTACGTGGTGGAATGGAGAGAGCTCCATCCAGGGGGTGACACACAGGTC
CCTCTAAACTGGCTACGGAGTCGACCCTACAATGTGTCTGCTCTGATTTCAGAGAACATAAAATCCTACATCTGTTATGAAATCCGTGTG
TATGCACTCTCAGGGGATCAAGGAGGATGCAGCTCCATCCTGGGTAACTCTAAGCACAAAGCACCACTGAGTGGCCCCCACATTAATGCC
ATCACAGAGGAAAAGGGGAGCATTTTAATTTCATGGAACAGCATTCCAGTCCAGGAGCAAATGGGCTGCCTCCTCCATTATAGGATATAC
TGGAAGGAACGGGACTCCAACTCCCAGCCTCAGCTCTGTGAAATTCCCTACAGAGTCTCCCAAAATTCACATCCAATAAACAGCCTGCAG
CCCCGAGTGACATATGTCCTGTGGATGACAGCTCTGACAGCTGCTGGTGAAAGTTCCCACGGAAATGAGAGGGAATTTTGTCTGCAAGGT
AAAGCCAATTGGATGGCGTTTGTGGCACCAAGCATTTGCATTGCTATCATCATGGTGGGCATTTTCTCAACGCATTACTTCCAGCAAAAG
AGAAGACACAGCTGCCCTTGGACAGGCTCCTGATAGACTGGCCCACGCCTGAAGATCCTGAACCGCTGGTCATCAGTGAAGTCCTTCATC
AAGTGACCCCAGTTTTCAGACATCCCCCCTGCTCCAACTGGCCACAAAGGGAAAAAGGAATCCAAGGTCATCAGGCCTCTGAGAAAGACA
TGATGCACAGTGCCTCAAGCCCACCACCTCCAAGAGCTCTCCAAGCTGAGAGCAGACAACTGGTGGATCTGTACAAGGTGCTGGAGAGCA

>75361_75361_7_ROR1-IL12RB2_ROR1_chr1_64475048_ENST00000371080_IL12RB2_chr1_67787285_ENST00000541374_length(amino acids)=701AA_BP=67
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDACKRGDVTVKPSHVILLGSTVN
ITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCKLACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQ
GTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPW
DIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPE
EEPTGMLDVWYMKRHIDYSRQQISLFWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGSSLP
TRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALISENIKSYICYEIR
VYALSGDQGGCSSILGNSKHKAPLSGPHINAITEEKGSILISWNSIPVQEQMGCLLHYRIYWKERDSNSQPQLCEIPYRVSQNSHPINSL

--------------------------------------------------------------
>75361_75361_8_ROR1-IL12RB2_ROR1_chr1_64475048_ENST00000371080_IL12RB2_chr1_67787285_ENST00000544434_length(transcript)=2872nt_BP=559nt
GAGCGAGAGAGGGAGCGTGGAGAGCTGGAGCAGCCGCCACCGCCGCCGCCGAGGGAGCCCCGGGACGGCAGCCCCTGGGCGCAGGGTGCG
CTGTTCTCGGAGTCCGACCCAGGGCGACTCACGCCCACTGGTGCGACCCGGACAGCCTGGGACTGACCCGCCGGCCCAGGCGAGGCTGCA
GCCAGAGGGCTGGGAAGGGATCGCGCTCGCGGCATCCAGAGGCGGCCAGGCGGAGGCGAGGGAGCAGGTTAGAGGGACAAAGAGCTTTGC
AGACGTCCCCGGCGTCCTGCGAGCGCCAGCGGCCGGGACGAGGCGGCCGGGAGCCCGGGAAGAGCCCGTGGATGTTCTGCGCGCGGCCTG
GGAGCCGCCGCCGCCGCCGCCTCAGCGAGAGGAGGAATGCACCGGCCGCGCCGCCGCGGGACGCGCCCGCCGCTCCTGGCGCTGCTGGCC
GCGCTGCTGCTGGCCGCACGCGGGGCTGCTGCCCAAGAAACAGAGCTGTCAGTCAGTGCTGAATTAGTGCCTACCTCATCATGGAACATC
TCAAGTGAACTCAACAAAGATGCGTGCAAGAGAGGCGATGTGACTGTGAAGCCTTCCCATGTAATTTTACTTGGATCCACTGTCAATATT
ACATGCTCTTTGAAGCCCAGACAAGGCTGCTTTCACTATTCCAGACGTAACAAGTTAATCCTGTACAAGTTTGACAGAAGAATCAATTTT
CACCATGGCCACTCCCTCAATTCTCAAGTCACAGGTCTTCCCCTTGGTACAACCTTGTTTGTCTGCAAACTGGCCTGTATCAATAGTGAT
GAAATTCAAATATGTGGAGCAGAGATCTTCGTTGGTGTTGCTCCAGAACAGCCTCAAAATTTATCCTGCATACAGAAGGGAGAACAGGGG
ACTGTGGCCTGCACCTGGGAAAGAGGACGAGACACCCACTTATACACTGAGTATACTCTACAGCTAAGTGGACCAAAAAATTTAACCTGG
CAGAAGCAATGTAAAGACATTTATTGTGACTATTTGGACTTTGGAATCAACCTCACCCCTGAATCACCTGAATCCAATTTCACAGCCAAG
GTTACTGCTGTCAATAGTCTTGGAAGCTCCTCTTCACTTCCATCCACATTCACATTCTTGGACATAGTGAGGCCTCTTCCTCCGTGGGAC
ATTAGAATCAAATTTCAAAAGGCTTCTGTGAGCAGATGTACCCTTTATTGGAGAGATGAGGGACTGGTACTGCTTAATCGACTCAGATAT
CGGCCCAGTAACAGCAGGCTCTGGAATATGGTTAATGTTACAAAGGCCAAAGGAAGACATGATTTGCTGGATCTGAAACCATTTACAGAA
TATGAATTTCAGATTTCCTCTAAGCTACATCTTTATAAGGGAAGTTGGAGTGATTGGAGTGAATCATTGAGAGCACAAACACCAGAAGAA
GAGCCTACTGGGATGTTAGATGTCTGGTACATGAAACGGCACATTGACTACAGTAGACAACAGATTTCTCTTTTCTGGAAGAATCTGAGT
GTCTCAGAGGCAAGAGGAAAAATTCTCCACTATCAGGTGACCTTGCAGGAGCTGACAGGAGGGAAAGCCATGACACAGAACATCACAGGA
CACACCTCCTGGACCACAGTCATTCCTAGAACCGGAAATTGGGCTGTGGCTGTGTCTGCAGCAAATTCAAAAGGCAGTTCTCTGCCCACT
CGTATTAACATAATGAACCTGTGTGAGGCAGGGTTGCTGGCTCCTCGCCAGGTCTCTGCAAACTCAGAGGGCATGGACAACATTCTGGTG
ACTTGGCAGCCTCCCAGGAAAGATCCCTCTGCTGTTCAGGAGTACGTGGTGGAATGGAGAGAGCTCCATCCAGGGGGTGACACACAGGTC
CCTCTAAACTGGCTACGGAGTCGACCCTACAATGTGTCTGCTCTGATTTCAGAAATTCCCTACAGAGTCTCCCAAAATTCACATCCAATA
AACAGCCTGCAGCCCCGAGTGACATATGTCCTGTGGATGACAGCTCTGACAGCTGCTGGTGAAAGTTCCCACGGAAATGAGAGGGAATTT
TGTCTGCAAGGTAAAGCCAATTGGATGGCGTTTGTGGCACCAAGCATTTGCATTGCTATCATCATGGTGGGCATTTTCTCAACGCATTAC
TTCCAGCAAAAGGTGTTTGTTCTCCTAGCAGCCCTCAGACCTCAGTGGTGTAGCAGAGAAATTCCAGATCCAGCAAATAGCACTTGCGCT
AAGAAATATCCCATTGCAGAGGAGAAGACACAGCTGCCCTTGGACAGGCTCCTGATAGACTGGCCCACGCCTGAAGATCCTGAACCGCTG
GTCATCAGTGAAGTCCTTCATCAAGTGACCCCAGTTTTCAGACATCCCCCCTGCTCCAACTGGCCACAAAGGGAAAAAGGAATCCAAGGT
CATCAGGCCTCTGAGAAAGACATGATGCACAGTGCCTCAAGCCCACCACCTCCAAGAGCTCTCCAAGCTGAGAGCAGACAACTGGTGGAT
CTGTACAAGGTGCTGGAGAGCAGGGGCTCCGACCCAAAGCCCGAAAACCCAGCCTGTCCCTGGACGGTGCTCCCAGCAGGTGACCTTCCC
ACCCATGATGGCTACTTACCCTCCAACATAGATGACCTCCCCTCACATGAGGCACCTCTCGCTGACTCTCTGGAAGAACTGGAGCCTCAG
CACATCTCCCTTTCTGTTTTCCCCTCAAGTTCTCTTCACCCACTCACCTTCTCCTGTGGTGATAAGCTGACTCTGGATCAGTTAAAGATG

>75361_75361_8_ROR1-IL12RB2_ROR1_chr1_64475048_ENST00000371080_IL12RB2_chr1_67787285_ENST00000544434_length(amino acids)=818AA_BP=67
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDACKRGDVTVKPSHVILLGSTVN
ITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCKLACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQ
GTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPW
DIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPE
EEPTGMLDVWYMKRHIDYSRQQISLFWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGSSLP
TRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALISEIPYRVSQNSHP
INSLQPRVTYVLWMTALTAAGESSHGNEREFCLQGKANWMAFVAPSICIAIIMVGIFSTHYFQQKVFVLLAALRPQWCSREIPDPANSTC
AKKYPIAEEKTQLPLDRLLIDWPTPEDPEPLVISEVLHQVTPVFRHPPCSNWPQREKGIQGHQASEKDMMHSASSPPPPRALQAESRQLV
DLYKVLESRGSDPKPENPACPWTVLPAGDLPTHDGYLPSNIDDLPSHEAPLADSLEELEPQHISLSVFPSSSLHPLTFSCGDKLTLDQLK

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Fusion Gene PPI Analysis for ROR1-IL12RB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ROR1-IL12RB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ROR1-IL12RB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource