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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ROR1-PGM1 (FusionGDB2 ID:75364)

Fusion Gene Summary for ROR1-PGM1

check button Fusion gene summary
Fusion gene informationFusion gene name: ROR1-PGM1
Fusion gene ID: 75364
HgeneTgene
Gene symbol

ROR1

PGM1

Gene ID

6095

5236

Gene nameRAR related orphan receptor Aphosphoglucomutase 1
SynonymsIDDECA|NR1F1|ROR1|ROR2|ROR3|RZR-ALPHA|RZRACDG1T|GSD14
Cytomap

15q22.2

1p31.3

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor ROR-alphaROR-alphanuclear receptor RZR-alphanuclear receptor subfamily 1 group F member 1retinoic acid receptor-related orphan receptor alpharetinoid-related orphan receptor alphathyroid hormone nuclear receptor alpha variant 4tranphosphoglucomutase-1PGM 1glucose phosphomutase 1
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000371079, ENST00000371080, 
ENST00000482426, ENST00000545203, 
ENST00000371083, ENST00000540265, 
ENST00000483707, ENST00000371084, 
Fusion gene scores* DoF score15 X 10 X 7=10508 X 7 X 6=336
# samples 179
** MAII scorelog2(17/1050*10)=-2.62678267641578
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ROR1 [Title/Abstract] AND PGM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointROR1(64240179)-PGM1(64095095), # samples:1
ROR1(64240179)-PGM1(64114188), # samples:1
Anticipated loss of major functional domain due to fusion event.ROR1-PGM1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ROR1-PGM1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
ROR1-PGM1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneROR1

GO:0006355

regulation of transcription, DNA-templated

9328355

HgeneROR1

GO:0030522

intracellular receptor signaling pathway

19965867

HgeneROR1

GO:0036315

cellular response to sterol

19965867

HgeneROR1

GO:0045893

positive regulation of transcription, DNA-templated

7926749

HgeneROR1

GO:0045944

positive regulation of transcription by RNA polymerase II

17545671|19955433

TgenePGM1

GO:0006006

glucose metabolic process

25288802


check buttonFusion gene breakpoints across ROR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PGM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-77-8144ROR1chr1

64240179

+PGM1chr1

64095095

+
ChimerDB4STADTCGA-VQ-A91N-01AROR1chr1

64240179

+PGM1chr1

64114188

+


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Fusion Gene ORF analysis for ROR1-PGM1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000371079ENST00000371083ROR1chr1

64240179

+PGM1chr1

64095095

+
5CDS-5UTRENST00000371079ENST00000540265ROR1chr1

64240179

+PGM1chr1

64095095

+
5CDS-5UTRENST00000371080ENST00000371083ROR1chr1

64240179

+PGM1chr1

64095095

+
5CDS-5UTRENST00000371080ENST00000540265ROR1chr1

64240179

+PGM1chr1

64095095

+
5CDS-intronENST00000371079ENST00000483707ROR1chr1

64240179

+PGM1chr1

64095095

+
5CDS-intronENST00000371079ENST00000483707ROR1chr1

64240179

+PGM1chr1

64114188

+
5CDS-intronENST00000371080ENST00000483707ROR1chr1

64240179

+PGM1chr1

64095095

+
5CDS-intronENST00000371080ENST00000483707ROR1chr1

64240179

+PGM1chr1

64114188

+
Frame-shiftENST00000371079ENST00000371084ROR1chr1

64240179

+PGM1chr1

64095095

+
Frame-shiftENST00000371080ENST00000371084ROR1chr1

64240179

+PGM1chr1

64095095

+
In-frameENST00000371079ENST00000371083ROR1chr1

64240179

+PGM1chr1

64114188

+
In-frameENST00000371079ENST00000371084ROR1chr1

64240179

+PGM1chr1

64114188

+
In-frameENST00000371079ENST00000540265ROR1chr1

64240179

+PGM1chr1

64114188

+
In-frameENST00000371080ENST00000371083ROR1chr1

64240179

+PGM1chr1

64114188

+
In-frameENST00000371080ENST00000371084ROR1chr1

64240179

+PGM1chr1

64114188

+
In-frameENST00000371080ENST00000540265ROR1chr1

64240179

+PGM1chr1

64114188

+
intron-3CDSENST00000482426ENST00000371083ROR1chr1

64240179

+PGM1chr1

64114188

+
intron-3CDSENST00000482426ENST00000371084ROR1chr1

64240179

+PGM1chr1

64095095

+
intron-3CDSENST00000482426ENST00000371084ROR1chr1

64240179

+PGM1chr1

64114188

+
intron-3CDSENST00000482426ENST00000540265ROR1chr1

64240179

+PGM1chr1

64114188

+
intron-3CDSENST00000545203ENST00000371083ROR1chr1

64240179

+PGM1chr1

64114188

+
intron-3CDSENST00000545203ENST00000371084ROR1chr1

64240179

+PGM1chr1

64095095

+
intron-3CDSENST00000545203ENST00000371084ROR1chr1

64240179

+PGM1chr1

64114188

+
intron-3CDSENST00000545203ENST00000540265ROR1chr1

64240179

+PGM1chr1

64114188

+
intron-5UTRENST00000482426ENST00000371083ROR1chr1

64240179

+PGM1chr1

64095095

+
intron-5UTRENST00000482426ENST00000540265ROR1chr1

64240179

+PGM1chr1

64095095

+
intron-5UTRENST00000545203ENST00000371083ROR1chr1

64240179

+PGM1chr1

64095095

+
intron-5UTRENST00000545203ENST00000540265ROR1chr1

64240179

+PGM1chr1

64095095

+
intron-intronENST00000482426ENST00000483707ROR1chr1

64240179

+PGM1chr1

64095095

+
intron-intronENST00000482426ENST00000483707ROR1chr1

64240179

+PGM1chr1

64114188

+
intron-intronENST00000545203ENST00000483707ROR1chr1

64240179

+PGM1chr1

64095095

+
intron-intronENST00000545203ENST00000483707ROR1chr1

64240179

+PGM1chr1

64114188

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371080ROR1chr164240179+ENST00000371084PGM1chr164114188+16024873571031224
ENST00000371080ROR1chr164240179+ENST00000540265PGM1chr164114188+15984873571031224
ENST00000371080ROR1chr164240179+ENST00000371083PGM1chr164114188+15784873571031224
ENST00000371079ROR1chr164240179+ENST00000371084PGM1chr164114188+15814663361010224
ENST00000371079ROR1chr164240179+ENST00000540265PGM1chr164114188+15774663361010224
ENST00000371079ROR1chr164240179+ENST00000371083PGM1chr164114188+15574663361010224

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371080ENST00000371084ROR1chr164240179+PGM1chr164114188+0.0029471270.9970529
ENST00000371080ENST00000540265ROR1chr164240179+PGM1chr164114188+0.002951290.9970488
ENST00000371080ENST00000371083ROR1chr164240179+PGM1chr164114188+0.0029480610.99705195
ENST00000371079ENST00000371084ROR1chr164240179+PGM1chr164114188+0.0020512450.9979488
ENST00000371079ENST00000540265ROR1chr164240179+PGM1chr164114188+0.0020255550.99797446
ENST00000371079ENST00000371083ROR1chr164240179+PGM1chr164114188+0.0019434140.9980566

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Fusion Genomic Features for ROR1-PGM1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ROR1chr164240179+PGM1chr164114187+0.0002474390.9997526
ROR1chr164240179+PGM1chr164095095+0.0001910690.99980897
ROR1chr164240179+PGM1chr164114187+0.0002474390.9997526
ROR1chr164240179+PGM1chr164095095+0.0001910690.99980897

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ROR1-PGM1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:64240179/chr1:64095095)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePGM1chr1:64240179chr1:64114188ENST00000540265611292_293184366.0RegionSubstrate binding
TgenePGM1chr1:64240179chr1:64114188ENST00000540265611376_378184366.0RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneROR1chr1:64240179chr1:64114188ENST00000371079+19753_78230938.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64240179chr1:64114188ENST00000371079+19784_85130938.0Compositional biasNote=Pro-rich
HgeneROR1chr1:64240179chr1:64114188ENST00000371079+19853_87630938.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64240179chr1:64114188ENST00000371080+17753_78230394.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64240179chr1:64114188ENST00000371080+17784_85130394.0Compositional biasNote=Pro-rich
HgeneROR1chr1:64240179chr1:64114188ENST00000371080+17853_87630394.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64240179chr1:64114188ENST00000545203+16753_7820389.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64240179chr1:64114188ENST00000545203+16784_8510389.0Compositional biasNote=Pro-rich
HgeneROR1chr1:64240179chr1:64114188ENST00000545203+16853_8760389.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64240179chr1:64114188ENST00000371079+19165_29930938.0DomainFZ
HgeneROR1chr1:64240179chr1:64114188ENST00000371079+19312_39130938.0DomainKringle
HgeneROR1chr1:64240179chr1:64114188ENST00000371079+1942_14730938.0DomainNote=Ig-like C2-type
HgeneROR1chr1:64240179chr1:64114188ENST00000371079+19473_74630938.0DomainProtein kinase
HgeneROR1chr1:64240179chr1:64114188ENST00000371080+17165_29930394.0DomainFZ
HgeneROR1chr1:64240179chr1:64114188ENST00000371080+17312_39130394.0DomainKringle
HgeneROR1chr1:64240179chr1:64114188ENST00000371080+1742_14730394.0DomainNote=Ig-like C2-type
HgeneROR1chr1:64240179chr1:64114188ENST00000371080+17473_74630394.0DomainProtein kinase
HgeneROR1chr1:64240179chr1:64114188ENST00000545203+16165_2990389.0DomainFZ
HgeneROR1chr1:64240179chr1:64114188ENST00000545203+16312_3910389.0DomainKringle
HgeneROR1chr1:64240179chr1:64114188ENST00000545203+1642_1470389.0DomainNote=Ig-like C2-type
HgeneROR1chr1:64240179chr1:64114188ENST00000545203+16473_7460389.0DomainProtein kinase
HgeneROR1chr1:64240179chr1:64114188ENST00000371079+19479_48730938.0Nucleotide bindingATP
HgeneROR1chr1:64240179chr1:64114188ENST00000371080+17479_48730394.0Nucleotide bindingATP
HgeneROR1chr1:64240179chr1:64114188ENST00000545203+16479_4870389.0Nucleotide bindingATP
HgeneROR1chr1:64240179chr1:64114188ENST00000371079+1930_40630938.0Topological domainExtracellular
HgeneROR1chr1:64240179chr1:64114188ENST00000371079+19428_93730938.0Topological domainCytoplasmic
HgeneROR1chr1:64240179chr1:64114188ENST00000371080+1730_40630394.0Topological domainExtracellular
HgeneROR1chr1:64240179chr1:64114188ENST00000371080+17428_93730394.0Topological domainCytoplasmic
HgeneROR1chr1:64240179chr1:64114188ENST00000545203+1630_4060389.0Topological domainExtracellular
HgeneROR1chr1:64240179chr1:64114188ENST00000545203+16428_9370389.0Topological domainCytoplasmic
HgeneROR1chr1:64240179chr1:64114188ENST00000371079+19407_42730938.0TransmembraneHelical
HgeneROR1chr1:64240179chr1:64114188ENST00000371080+17407_42730394.0TransmembraneHelical
HgeneROR1chr1:64240179chr1:64114188ENST00000545203+16407_4270389.0TransmembraneHelical
TgenePGM1chr1:64240179chr1:64114188ENST00000371083611117_118399581.0RegionSubstrate binding
TgenePGM1chr1:64240179chr1:64114188ENST00000371083611292_293399581.0RegionSubstrate binding
TgenePGM1chr1:64240179chr1:64114188ENST00000371083611376_378399581.0RegionSubstrate binding
TgenePGM1chr1:64240179chr1:64114188ENST00000371084611117_118381563.0RegionSubstrate binding
TgenePGM1chr1:64240179chr1:64114188ENST00000371084611292_293381563.0RegionSubstrate binding
TgenePGM1chr1:64240179chr1:64114188ENST00000371084611376_378381563.0RegionSubstrate binding
TgenePGM1chr1:64240179chr1:64114188ENST00000540265611117_118184366.0RegionSubstrate binding


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Fusion Gene Sequence for ROR1-PGM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>75364_75364_1_ROR1-PGM1_ROR1_chr1_64240179_ENST00000371079_PGM1_chr1_64114188_ENST00000371083_length(transcript)=1557nt_BP=466nt
GAGCTGGAGCAGCCGCCACCGCCGCCGCCGAGGGAGCCCCGGGACGGCAGCCCCTGGGCGCAGGGTGCGCTGTTCTCGGAGTCCGACCCA
GGGCGACTCACGCCCACTGGTGCGACCCGGACAGCCTGGGACTGACCCGCCGGCCCAGGCGAGGCTGCAGCCAGAGGGCTGGGAAGGGAT
CGCGCTCGCGGCATCCAGAGGCGGCCAGGCGGAGGCGAGGGAGCAGGTTAGAGGGACAAAGAGCTTTGCAGACGTCCCCGGCGTCCTGCG
AGCGCCAGCGGCCGGGACGAGGCGGCCGGGAGCCCGGGAAGAGCCCGTGGATGTTCTGCGCGCGGCCTGGGAGCCGCCGCCGCCGCCGCC
TCAGCGAGAGGAGGAATGCACCGGCCGCGCCGCCGCGGGACGCGCCCGCCGCTCCTGGCGCTGCTGGCCGCGCTGCTGCTGGCCGCACGC
GGGGCTGCTGCCCAAGGTTCTGACCACATCCGTGAGAAAGATGGACTGTGGGCTGTCCTTGCCTGGCTCTCCATCCTAGCCACCCGCAAG
CAGAGTGTGGAGGACATTCTCAAAGATCATTGGCAAAAGTATGGCCGGAATTTCTTCACCAGGTATGATTACGAGGAGGTGGAAGCTGAG
GGCGCAAACAAAATGATGAAGGACTTGGAGGCCCTGATGTTTGATCGCTCCTTTGTGGGGAAGCAGTTCTCAGCAAATGACAAAGTTTAC
ACTGTGGAGAAGGCCGATAACTTTGAATACAGCGACCCAGTGGATGGAAGCATTTCAAGAAATCAGGGCTTGCGCCTCATTTTCACAGAT
GGTTCTCGAATCGTCTTCCGACTGAGCGGCACTGGGAGTGCCGGGGCCACCATTCGGCTGTACATCGATAGCTATGAGAAGGACGTTGCC
AAGATTAACCAGGACCCCCAGGTCATGTTGGCCCCCCTTATTTCCATTGCTCTGAAAGTGTCCCAGCTGCAGGAGAGGACGGGACGCACT
GCACCCACTGTCATCACCTAAGAAGACAGGCCTGATGTGGTACGTCCCTCCACCCCCGGACCCATCCAAGTCATCTGATTGAAGAGCATG
ACAGAAACAAAATGTATTCACCAAGCATTTTAGGATTTGACTTTTTCACTAACCAGTTGACGAGCAGTGCATTTACAAGGCACTGCCAAA
CAAGATGCCCTTGGGAGCTGTGAGGGAAAGAGGACCTGCGGGCTTAGATCAATCTCAATTCCTTTTCATGCCCTCCTGCATTGCTGCTGC
GTGGGTATTTGTCTCCTTAGCCATCAGGTACAGTTTACACTACAATGTAAGCTATAGGTGGAGCATCAGCAGTGAGTGAGGCCATTCTTC
ATCCTTAGGATGTGGCAATGAAATGATGGTGCAAGTTCCTTTCTCTTTTGTGAATCTTTCCCCCCATTTCCTGTTTACATGTAACCCAAC
AAAATGCAATTTCTAGTGCCTTCTGTCCAATCAGTTCTTTCCTCTGAGTGAGACGTACTTGGCTACAGATTTCTGCCTTGTTTTGCGACA

>75364_75364_1_ROR1-PGM1_ROR1_chr1_64240179_ENST00000371079_PGM1_chr1_64114188_ENST00000371083_length(amino acids)=224AA_BP=43
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQGSDHIREKDGLWAVLAWLSILATRKQSVEDILKDHWQKYGRNFFTRY
DYEEVEAEGANKMMKDLEALMFDRSFVGKQFSANDKVYTVEKADNFEYSDPVDGSISRNQGLRLIFTDGSRIVFRLSGTGSAGATIRLYI

--------------------------------------------------------------
>75364_75364_2_ROR1-PGM1_ROR1_chr1_64240179_ENST00000371079_PGM1_chr1_64114188_ENST00000371084_length(transcript)=1581nt_BP=466nt
GAGCTGGAGCAGCCGCCACCGCCGCCGCCGAGGGAGCCCCGGGACGGCAGCCCCTGGGCGCAGGGTGCGCTGTTCTCGGAGTCCGACCCA
GGGCGACTCACGCCCACTGGTGCGACCCGGACAGCCTGGGACTGACCCGCCGGCCCAGGCGAGGCTGCAGCCAGAGGGCTGGGAAGGGAT
CGCGCTCGCGGCATCCAGAGGCGGCCAGGCGGAGGCGAGGGAGCAGGTTAGAGGGACAAAGAGCTTTGCAGACGTCCCCGGCGTCCTGCG
AGCGCCAGCGGCCGGGACGAGGCGGCCGGGAGCCCGGGAAGAGCCCGTGGATGTTCTGCGCGCGGCCTGGGAGCCGCCGCCGCCGCCGCC
TCAGCGAGAGGAGGAATGCACCGGCCGCGCCGCCGCGGGACGCGCCCGCCGCTCCTGGCGCTGCTGGCCGCGCTGCTGCTGGCCGCACGC
GGGGCTGCTGCCCAAGGTTCTGACCACATCCGTGAGAAAGATGGACTGTGGGCTGTCCTTGCCTGGCTCTCCATCCTAGCCACCCGCAAG
CAGAGTGTGGAGGACATTCTCAAAGATCATTGGCAAAAGTATGGCCGGAATTTCTTCACCAGGTATGATTACGAGGAGGTGGAAGCTGAG
GGCGCAAACAAAATGATGAAGGACTTGGAGGCCCTGATGTTTGATCGCTCCTTTGTGGGGAAGCAGTTCTCAGCAAATGACAAAGTTTAC
ACTGTGGAGAAGGCCGATAACTTTGAATACAGCGACCCAGTGGATGGAAGCATTTCAAGAAATCAGGGCTTGCGCCTCATTTTCACAGAT
GGTTCTCGAATCGTCTTCCGACTGAGCGGCACTGGGAGTGCCGGGGCCACCATTCGGCTGTACATCGATAGCTATGAGAAGGACGTTGCC
AAGATTAACCAGGACCCCCAGGTCATGTTGGCCCCCCTTATTTCCATTGCTCTGAAAGTGTCCCAGCTGCAGGAGAGGACGGGACGCACT
GCACCCACTGTCATCACCTAAGAAGACAGGCCTGATGTGGTACGTCCCTCCACCCCCGGACCCATCCAAGTCATCTGATTGAAGAGCATG
ACAGAAACAAAATGTATTCACCAAGCATTTTAGGATTTGACTTTTTCACTAACCAGTTGACGAGCAGTGCATTTACAAGGCACTGCCAAA
CAAGATGCCCTTGGGAGCTGTGAGGGAAAGAGGACCTGCGGGCTTAGATCAATCTCAATTCCTTTTCATGCCCTCCTGCATTGCTGCTGC
GTGGGTATTTGTCTCCTTAGCCATCAGGTACAGTTTACACTACAATGTAAGCTATAGGTGGAGCATCAGCAGTGAGTGAGGCCATTCTTC
ATCCTTAGGATGTGGCAATGAAATGATGGTGCAAGTTCCTTTCTCTTTTGTGAATCTTTCCCCCCATTTCCTGTTTACATGTAACCCAAC
AAAATGCAATTTCTAGTGCCTTCTGTCCAATCAGTTCTTTCCTCTGAGTGAGACGTACTTGGCTACAGATTTCTGCCTTGTTTTGCGACA

>75364_75364_2_ROR1-PGM1_ROR1_chr1_64240179_ENST00000371079_PGM1_chr1_64114188_ENST00000371084_length(amino acids)=224AA_BP=43
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQGSDHIREKDGLWAVLAWLSILATRKQSVEDILKDHWQKYGRNFFTRY
DYEEVEAEGANKMMKDLEALMFDRSFVGKQFSANDKVYTVEKADNFEYSDPVDGSISRNQGLRLIFTDGSRIVFRLSGTGSAGATIRLYI

--------------------------------------------------------------
>75364_75364_3_ROR1-PGM1_ROR1_chr1_64240179_ENST00000371079_PGM1_chr1_64114188_ENST00000540265_length(transcript)=1577nt_BP=466nt
GAGCTGGAGCAGCCGCCACCGCCGCCGCCGAGGGAGCCCCGGGACGGCAGCCCCTGGGCGCAGGGTGCGCTGTTCTCGGAGTCCGACCCA
GGGCGACTCACGCCCACTGGTGCGACCCGGACAGCCTGGGACTGACCCGCCGGCCCAGGCGAGGCTGCAGCCAGAGGGCTGGGAAGGGAT
CGCGCTCGCGGCATCCAGAGGCGGCCAGGCGGAGGCGAGGGAGCAGGTTAGAGGGACAAAGAGCTTTGCAGACGTCCCCGGCGTCCTGCG
AGCGCCAGCGGCCGGGACGAGGCGGCCGGGAGCCCGGGAAGAGCCCGTGGATGTTCTGCGCGCGGCCTGGGAGCCGCCGCCGCCGCCGCC
TCAGCGAGAGGAGGAATGCACCGGCCGCGCCGCCGCGGGACGCGCCCGCCGCTCCTGGCGCTGCTGGCCGCGCTGCTGCTGGCCGCACGC
GGGGCTGCTGCCCAAGGTTCTGACCACATCCGTGAGAAAGATGGACTGTGGGCTGTCCTTGCCTGGCTCTCCATCCTAGCCACCCGCAAG
CAGAGTGTGGAGGACATTCTCAAAGATCATTGGCAAAAGTATGGCCGGAATTTCTTCACCAGGTATGATTACGAGGAGGTGGAAGCTGAG
GGCGCAAACAAAATGATGAAGGACTTGGAGGCCCTGATGTTTGATCGCTCCTTTGTGGGGAAGCAGTTCTCAGCAAATGACAAAGTTTAC
ACTGTGGAGAAGGCCGATAACTTTGAATACAGCGACCCAGTGGATGGAAGCATTTCAAGAAATCAGGGCTTGCGCCTCATTTTCACAGAT
GGTTCTCGAATCGTCTTCCGACTGAGCGGCACTGGGAGTGCCGGGGCCACCATTCGGCTGTACATCGATAGCTATGAGAAGGACGTTGCC
AAGATTAACCAGGACCCCCAGGTCATGTTGGCCCCCCTTATTTCCATTGCTCTGAAAGTGTCCCAGCTGCAGGAGAGGACGGGACGCACT
GCACCCACTGTCATCACCTAAGAAGACAGGCCTGATGTGGTACGTCCCTCCACCCCCGGACCCATCCAAGTCATCTGATTGAAGAGCATG
ACAGAAACAAAATGTATTCACCAAGCATTTTAGGATTTGACTTTTTCACTAACCAGTTGACGAGCAGTGCATTTACAAGGCACTGCCAAA
CAAGATGCCCTTGGGAGCTGTGAGGGAAAGAGGACCTGCGGGCTTAGATCAATCTCAATTCCTTTTCATGCCCTCCTGCATTGCTGCTGC
GTGGGTATTTGTCTCCTTAGCCATCAGGTACAGTTTACACTACAATGTAAGCTATAGGTGGAGCATCAGCAGTGAGTGAGGCCATTCTTC
ATCCTTAGGATGTGGCAATGAAATGATGGTGCAAGTTCCTTTCTCTTTTGTGAATCTTTCCCCCCATTTCCTGTTTACATGTAACCCAAC
AAAATGCAATTTCTAGTGCCTTCTGTCCAATCAGTTCTTTCCTCTGAGTGAGACGTACTTGGCTACAGATTTCTGCCTTGTTTTGCGACA

>75364_75364_3_ROR1-PGM1_ROR1_chr1_64240179_ENST00000371079_PGM1_chr1_64114188_ENST00000540265_length(amino acids)=224AA_BP=43
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQGSDHIREKDGLWAVLAWLSILATRKQSVEDILKDHWQKYGRNFFTRY
DYEEVEAEGANKMMKDLEALMFDRSFVGKQFSANDKVYTVEKADNFEYSDPVDGSISRNQGLRLIFTDGSRIVFRLSGTGSAGATIRLYI

--------------------------------------------------------------
>75364_75364_4_ROR1-PGM1_ROR1_chr1_64240179_ENST00000371080_PGM1_chr1_64114188_ENST00000371083_length(transcript)=1578nt_BP=487nt
GAGCGAGAGAGGGAGCGTGGAGAGCTGGAGCAGCCGCCACCGCCGCCGCCGAGGGAGCCCCGGGACGGCAGCCCCTGGGCGCAGGGTGCG
CTGTTCTCGGAGTCCGACCCAGGGCGACTCACGCCCACTGGTGCGACCCGGACAGCCTGGGACTGACCCGCCGGCCCAGGCGAGGCTGCA
GCCAGAGGGCTGGGAAGGGATCGCGCTCGCGGCATCCAGAGGCGGCCAGGCGGAGGCGAGGGAGCAGGTTAGAGGGACAAAGAGCTTTGC
AGACGTCCCCGGCGTCCTGCGAGCGCCAGCGGCCGGGACGAGGCGGCCGGGAGCCCGGGAAGAGCCCGTGGATGTTCTGCGCGCGGCCTG
GGAGCCGCCGCCGCCGCCGCCTCAGCGAGAGGAGGAATGCACCGGCCGCGCCGCCGCGGGACGCGCCCGCCGCTCCTGGCGCTGCTGGCC
GCGCTGCTGCTGGCCGCACGCGGGGCTGCTGCCCAAGGTTCTGACCACATCCGTGAGAAAGATGGACTGTGGGCTGTCCTTGCCTGGCTC
TCCATCCTAGCCACCCGCAAGCAGAGTGTGGAGGACATTCTCAAAGATCATTGGCAAAAGTATGGCCGGAATTTCTTCACCAGGTATGAT
TACGAGGAGGTGGAAGCTGAGGGCGCAAACAAAATGATGAAGGACTTGGAGGCCCTGATGTTTGATCGCTCCTTTGTGGGGAAGCAGTTC
TCAGCAAATGACAAAGTTTACACTGTGGAGAAGGCCGATAACTTTGAATACAGCGACCCAGTGGATGGAAGCATTTCAAGAAATCAGGGC
TTGCGCCTCATTTTCACAGATGGTTCTCGAATCGTCTTCCGACTGAGCGGCACTGGGAGTGCCGGGGCCACCATTCGGCTGTACATCGAT
AGCTATGAGAAGGACGTTGCCAAGATTAACCAGGACCCCCAGGTCATGTTGGCCCCCCTTATTTCCATTGCTCTGAAAGTGTCCCAGCTG
CAGGAGAGGACGGGACGCACTGCACCCACTGTCATCACCTAAGAAGACAGGCCTGATGTGGTACGTCCCTCCACCCCCGGACCCATCCAA
GTCATCTGATTGAAGAGCATGACAGAAACAAAATGTATTCACCAAGCATTTTAGGATTTGACTTTTTCACTAACCAGTTGACGAGCAGTG
CATTTACAAGGCACTGCCAAACAAGATGCCCTTGGGAGCTGTGAGGGAAAGAGGACCTGCGGGCTTAGATCAATCTCAATTCCTTTTCAT
GCCCTCCTGCATTGCTGCTGCGTGGGTATTTGTCTCCTTAGCCATCAGGTACAGTTTACACTACAATGTAAGCTATAGGTGGAGCATCAG
CAGTGAGTGAGGCCATTCTTCATCCTTAGGATGTGGCAATGAAATGATGGTGCAAGTTCCTTTCTCTTTTGTGAATCTTTCCCCCCATTT
CCTGTTTACATGTAACCCAACAAAATGCAATTTCTAGTGCCTTCTGTCCAATCAGTTCTTTCCTCTGAGTGAGACGTACTTGGCTACAGA

>75364_75364_4_ROR1-PGM1_ROR1_chr1_64240179_ENST00000371080_PGM1_chr1_64114188_ENST00000371083_length(amino acids)=224AA_BP=43
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQGSDHIREKDGLWAVLAWLSILATRKQSVEDILKDHWQKYGRNFFTRY
DYEEVEAEGANKMMKDLEALMFDRSFVGKQFSANDKVYTVEKADNFEYSDPVDGSISRNQGLRLIFTDGSRIVFRLSGTGSAGATIRLYI

--------------------------------------------------------------
>75364_75364_5_ROR1-PGM1_ROR1_chr1_64240179_ENST00000371080_PGM1_chr1_64114188_ENST00000371084_length(transcript)=1602nt_BP=487nt
GAGCGAGAGAGGGAGCGTGGAGAGCTGGAGCAGCCGCCACCGCCGCCGCCGAGGGAGCCCCGGGACGGCAGCCCCTGGGCGCAGGGTGCG
CTGTTCTCGGAGTCCGACCCAGGGCGACTCACGCCCACTGGTGCGACCCGGACAGCCTGGGACTGACCCGCCGGCCCAGGCGAGGCTGCA
GCCAGAGGGCTGGGAAGGGATCGCGCTCGCGGCATCCAGAGGCGGCCAGGCGGAGGCGAGGGAGCAGGTTAGAGGGACAAAGAGCTTTGC
AGACGTCCCCGGCGTCCTGCGAGCGCCAGCGGCCGGGACGAGGCGGCCGGGAGCCCGGGAAGAGCCCGTGGATGTTCTGCGCGCGGCCTG
GGAGCCGCCGCCGCCGCCGCCTCAGCGAGAGGAGGAATGCACCGGCCGCGCCGCCGCGGGACGCGCCCGCCGCTCCTGGCGCTGCTGGCC
GCGCTGCTGCTGGCCGCACGCGGGGCTGCTGCCCAAGGTTCTGACCACATCCGTGAGAAAGATGGACTGTGGGCTGTCCTTGCCTGGCTC
TCCATCCTAGCCACCCGCAAGCAGAGTGTGGAGGACATTCTCAAAGATCATTGGCAAAAGTATGGCCGGAATTTCTTCACCAGGTATGAT
TACGAGGAGGTGGAAGCTGAGGGCGCAAACAAAATGATGAAGGACTTGGAGGCCCTGATGTTTGATCGCTCCTTTGTGGGGAAGCAGTTC
TCAGCAAATGACAAAGTTTACACTGTGGAGAAGGCCGATAACTTTGAATACAGCGACCCAGTGGATGGAAGCATTTCAAGAAATCAGGGC
TTGCGCCTCATTTTCACAGATGGTTCTCGAATCGTCTTCCGACTGAGCGGCACTGGGAGTGCCGGGGCCACCATTCGGCTGTACATCGAT
AGCTATGAGAAGGACGTTGCCAAGATTAACCAGGACCCCCAGGTCATGTTGGCCCCCCTTATTTCCATTGCTCTGAAAGTGTCCCAGCTG
CAGGAGAGGACGGGACGCACTGCACCCACTGTCATCACCTAAGAAGACAGGCCTGATGTGGTACGTCCCTCCACCCCCGGACCCATCCAA
GTCATCTGATTGAAGAGCATGACAGAAACAAAATGTATTCACCAAGCATTTTAGGATTTGACTTTTTCACTAACCAGTTGACGAGCAGTG
CATTTACAAGGCACTGCCAAACAAGATGCCCTTGGGAGCTGTGAGGGAAAGAGGACCTGCGGGCTTAGATCAATCTCAATTCCTTTTCAT
GCCCTCCTGCATTGCTGCTGCGTGGGTATTTGTCTCCTTAGCCATCAGGTACAGTTTACACTACAATGTAAGCTATAGGTGGAGCATCAG
CAGTGAGTGAGGCCATTCTTCATCCTTAGGATGTGGCAATGAAATGATGGTGCAAGTTCCTTTCTCTTTTGTGAATCTTTCCCCCCATTT
CCTGTTTACATGTAACCCAACAAAATGCAATTTCTAGTGCCTTCTGTCCAATCAGTTCTTTCCTCTGAGTGAGACGTACTTGGCTACAGA

>75364_75364_5_ROR1-PGM1_ROR1_chr1_64240179_ENST00000371080_PGM1_chr1_64114188_ENST00000371084_length(amino acids)=224AA_BP=43
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQGSDHIREKDGLWAVLAWLSILATRKQSVEDILKDHWQKYGRNFFTRY
DYEEVEAEGANKMMKDLEALMFDRSFVGKQFSANDKVYTVEKADNFEYSDPVDGSISRNQGLRLIFTDGSRIVFRLSGTGSAGATIRLYI

--------------------------------------------------------------
>75364_75364_6_ROR1-PGM1_ROR1_chr1_64240179_ENST00000371080_PGM1_chr1_64114188_ENST00000540265_length(transcript)=1598nt_BP=487nt
GAGCGAGAGAGGGAGCGTGGAGAGCTGGAGCAGCCGCCACCGCCGCCGCCGAGGGAGCCCCGGGACGGCAGCCCCTGGGCGCAGGGTGCG
CTGTTCTCGGAGTCCGACCCAGGGCGACTCACGCCCACTGGTGCGACCCGGACAGCCTGGGACTGACCCGCCGGCCCAGGCGAGGCTGCA
GCCAGAGGGCTGGGAAGGGATCGCGCTCGCGGCATCCAGAGGCGGCCAGGCGGAGGCGAGGGAGCAGGTTAGAGGGACAAAGAGCTTTGC
AGACGTCCCCGGCGTCCTGCGAGCGCCAGCGGCCGGGACGAGGCGGCCGGGAGCCCGGGAAGAGCCCGTGGATGTTCTGCGCGCGGCCTG
GGAGCCGCCGCCGCCGCCGCCTCAGCGAGAGGAGGAATGCACCGGCCGCGCCGCCGCGGGACGCGCCCGCCGCTCCTGGCGCTGCTGGCC
GCGCTGCTGCTGGCCGCACGCGGGGCTGCTGCCCAAGGTTCTGACCACATCCGTGAGAAAGATGGACTGTGGGCTGTCCTTGCCTGGCTC
TCCATCCTAGCCACCCGCAAGCAGAGTGTGGAGGACATTCTCAAAGATCATTGGCAAAAGTATGGCCGGAATTTCTTCACCAGGTATGAT
TACGAGGAGGTGGAAGCTGAGGGCGCAAACAAAATGATGAAGGACTTGGAGGCCCTGATGTTTGATCGCTCCTTTGTGGGGAAGCAGTTC
TCAGCAAATGACAAAGTTTACACTGTGGAGAAGGCCGATAACTTTGAATACAGCGACCCAGTGGATGGAAGCATTTCAAGAAATCAGGGC
TTGCGCCTCATTTTCACAGATGGTTCTCGAATCGTCTTCCGACTGAGCGGCACTGGGAGTGCCGGGGCCACCATTCGGCTGTACATCGAT
AGCTATGAGAAGGACGTTGCCAAGATTAACCAGGACCCCCAGGTCATGTTGGCCCCCCTTATTTCCATTGCTCTGAAAGTGTCCCAGCTG
CAGGAGAGGACGGGACGCACTGCACCCACTGTCATCACCTAAGAAGACAGGCCTGATGTGGTACGTCCCTCCACCCCCGGACCCATCCAA
GTCATCTGATTGAAGAGCATGACAGAAACAAAATGTATTCACCAAGCATTTTAGGATTTGACTTTTTCACTAACCAGTTGACGAGCAGTG
CATTTACAAGGCACTGCCAAACAAGATGCCCTTGGGAGCTGTGAGGGAAAGAGGACCTGCGGGCTTAGATCAATCTCAATTCCTTTTCAT
GCCCTCCTGCATTGCTGCTGCGTGGGTATTTGTCTCCTTAGCCATCAGGTACAGTTTACACTACAATGTAAGCTATAGGTGGAGCATCAG
CAGTGAGTGAGGCCATTCTTCATCCTTAGGATGTGGCAATGAAATGATGGTGCAAGTTCCTTTCTCTTTTGTGAATCTTTCCCCCCATTT
CCTGTTTACATGTAACCCAACAAAATGCAATTTCTAGTGCCTTCTGTCCAATCAGTTCTTTCCTCTGAGTGAGACGTACTTGGCTACAGA

>75364_75364_6_ROR1-PGM1_ROR1_chr1_64240179_ENST00000371080_PGM1_chr1_64114188_ENST00000540265_length(amino acids)=224AA_BP=43
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQGSDHIREKDGLWAVLAWLSILATRKQSVEDILKDHWQKYGRNFFTRY
DYEEVEAEGANKMMKDLEALMFDRSFVGKQFSANDKVYTVEKADNFEYSDPVDGSISRNQGLRLIFTDGSRIVFRLSGTGSAGATIRLYI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ROR1-PGM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ROR1-PGM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ROR1-PGM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource