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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RORA-ANXA2 (FusionGDB2 ID:75381)

Fusion Gene Summary for RORA-ANXA2

check button Fusion gene summary
Fusion gene informationFusion gene name: RORA-ANXA2
Fusion gene ID: 75381
HgeneTgene
Gene symbol

RORA

ANXA2

Gene ID

6095

302

Gene nameRAR related orphan receptor Aannexin A2
SynonymsIDDECA|NR1F1|ROR1|ROR2|ROR3|RZR-ALPHA|RZRAANX2|ANX2L4|CAL1H|HEL-S-270|LIP2|LPC2|LPC2D|P36|PAP-IV
Cytomap

15q22.2

15q22.2

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor ROR-alphaROR-alphanuclear receptor RZR-alphanuclear receptor subfamily 1 group F member 1retinoic acid receptor-related orphan receptor alpharetinoid-related orphan receptor alphathyroid hormone nuclear receptor alpha variant 4tranannexin A2annexin IIannexin-2calpactin I heavy chaincalpactin I heavy polypeptidecalpactin-1 heavy chainchromobindin 8epididymis secretory protein Li 270epididymis secretory sperm binding proteinlipocortin IIplacental anticoagulant protein IVpr
Modification date2020032220200313
UniProtAcc.

A6NMY6

Ensembl transtripts involved in fusion geneENST00000261523, ENST00000309157, 
ENST00000335670, ENST00000449337, 
ENST00000560004, 		ENST00000557937, 
ENST00000332680, ENST00000396024, 
ENST00000421017, ENST00000451270, 
Fusion gene scores* DoF score19 X 18 X 13=444633 X 12 X 13=5148
# samples 2539
** MAII scorelog2(25/4446*10)=-4.1525079483649
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(39/5148*10)=-3.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RORA [Title/Abstract] AND ANXA2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRORA(60884585)-ANXA2(60678285), # samples:2
RORA(61521252)-ANXA2(60678285), # samples:2
ANXA2(60674540)-RORA(60824050), # samples:1
ANXA2(60674541)-RORA(60824050), # samples:1
Anticipated loss of major functional domain due to fusion event.RORA-ANXA2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
RORA-ANXA2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
RORA-ANXA2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRORA

GO:0006355

regulation of transcription, DNA-templated

9328355

HgeneRORA

GO:0030522

intracellular receptor signaling pathway

19965867

HgeneRORA

GO:0036315

cellular response to sterol

19965867

HgeneRORA

GO:0045893

positive regulation of transcription, DNA-templated

7926749

HgeneRORA

GO:0045944

positive regulation of transcription by RNA polymerase II

17545671|19955433

TgeneANXA2

GO:0001921

positive regulation of receptor recycling

22848640

TgeneANXA2

GO:0031340

positive regulation of vesicle fusion

2138016

TgeneANXA2

GO:0032804

negative regulation of low-density lipoprotein particle receptor catabolic process

22848640

TgeneANXA2

GO:0036035

osteoclast development

7961821

TgeneANXA2

GO:1905581

positive regulation of low-density lipoprotein particle clearance

22848640

TgeneANXA2

GO:1905597

positive regulation of low-density lipoprotein particle receptor binding

22848640

TgeneANXA2

GO:1905602

positive regulation of receptor-mediated endocytosis involved in cholesterol transport

22848640


check buttonFusion gene breakpoints across RORA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ANXA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-GV-A3QI-01ARORAchr15

60823965

-ANXA2chr15

60656722

-
ChimerDB4HNSCTCGA-CV-7418RORAchr15

60884585

-ANXA2chr15

60678285

-
ChimerDB4LIHCTCGA-BC-4073-01BRORAchr15

61521252

-ANXA2chr15

60678285

-
ChimerDB4LIHCTCGA-BC-4073RORAchr15

61521251

-ANXA2chr15

60678285

-
ChimerDB4LIHCTCGA-CC-A3MB-01ARORAchr15

61521252

-ANXA2chr15

60678285

-
ChimerDB4STADTCGA-VQ-A8P3-01ARORAchr15

60884586

-ANXA2chr15

60678285

-
ChimerDB4STADTCGA-VQ-A8P3-01ARORAchr15

60885007

-ANXA2chr15

60678285

-
ChimerDB4STADTCGA-VQ-A8P3RORAchr15

60884585

-ANXA2chr15

60678285

-


Top

Fusion Gene ORF analysis for RORA-ANXA2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000261523ENST00000557937RORAchr15

60823965

-ANXA2chr15

60656722

-
5CDS-5UTRENST00000309157ENST00000557937RORAchr15

60823965

-ANXA2chr15

60656722

-
5CDS-5UTRENST00000335670ENST00000332680RORAchr15

61521251

-ANXA2chr15

60678285

-
5CDS-5UTRENST00000335670ENST00000332680RORAchr15

61521252

-ANXA2chr15

60678285

-
5CDS-5UTRENST00000335670ENST00000396024RORAchr15

61521251

-ANXA2chr15

60678285

-
5CDS-5UTRENST00000335670ENST00000396024RORAchr15

61521252

-ANXA2chr15

60678285

-
5CDS-5UTRENST00000335670ENST00000421017RORAchr15

61521251

-ANXA2chr15

60678285

-
5CDS-5UTRENST00000335670ENST00000421017RORAchr15

61521252

-ANXA2chr15

60678285

-
5CDS-5UTRENST00000335670ENST00000451270RORAchr15

61521251

-ANXA2chr15

60678285

-
5CDS-5UTRENST00000335670ENST00000451270RORAchr15

61521252

-ANXA2chr15

60678285

-
5CDS-5UTRENST00000335670ENST00000557937RORAchr15

60823965

-ANXA2chr15

60656722

-
5CDS-5UTRENST00000335670ENST00000557937RORAchr15

61521251

-ANXA2chr15

60678285

-
5CDS-5UTRENST00000335670ENST00000557937RORAchr15

61521252

-ANXA2chr15

60678285

-
5CDS-5UTRENST00000449337ENST00000332680RORAchr15

60884585

-ANXA2chr15

60678285

-
5CDS-5UTRENST00000449337ENST00000332680RORAchr15

60884586

-ANXA2chr15

60678285

-
5CDS-5UTRENST00000449337ENST00000396024RORAchr15

60884585

-ANXA2chr15

60678285

-
5CDS-5UTRENST00000449337ENST00000396024RORAchr15

60884586

-ANXA2chr15

60678285

-
5CDS-5UTRENST00000449337ENST00000421017RORAchr15

60884585

-ANXA2chr15

60678285

-
5CDS-5UTRENST00000449337ENST00000421017RORAchr15

60884586

-ANXA2chr15

60678285

-
5CDS-5UTRENST00000449337ENST00000451270RORAchr15

60884585

-ANXA2chr15

60678285

-
5CDS-5UTRENST00000449337ENST00000451270RORAchr15

60884586

-ANXA2chr15

60678285

-
5CDS-5UTRENST00000449337ENST00000557937RORAchr15

60823965

-ANXA2chr15

60656722

-
5CDS-5UTRENST00000449337ENST00000557937RORAchr15

60884585

-ANXA2chr15

60678285

-
5CDS-5UTRENST00000449337ENST00000557937RORAchr15

60884586

-ANXA2chr15

60678285

-
5UTR-3CDSENST00000560004ENST00000332680RORAchr15

60823965

-ANXA2chr15

60656722

-
5UTR-3CDSENST00000560004ENST00000396024RORAchr15

60823965

-ANXA2chr15

60656722

-
5UTR-3CDSENST00000560004ENST00000421017RORAchr15

60823965

-ANXA2chr15

60656722

-
5UTR-3CDSENST00000560004ENST00000451270RORAchr15

60823965

-ANXA2chr15

60656722

-
5UTR-5UTRENST00000560004ENST00000557937RORAchr15

60823965

-ANXA2chr15

60656722

-
Frame-shiftENST00000261523ENST00000332680RORAchr15

60823965

-ANXA2chr15

60656722

-
Frame-shiftENST00000261523ENST00000396024RORAchr15

60823965

-ANXA2chr15

60656722

-
Frame-shiftENST00000261523ENST00000421017RORAchr15

60823965

-ANXA2chr15

60656722

-
Frame-shiftENST00000261523ENST00000451270RORAchr15

60823965

-ANXA2chr15

60656722

-
Frame-shiftENST00000309157ENST00000332680RORAchr15

60823965

-ANXA2chr15

60656722

-
Frame-shiftENST00000309157ENST00000396024RORAchr15

60823965

-ANXA2chr15

60656722

-
Frame-shiftENST00000309157ENST00000421017RORAchr15

60823965

-ANXA2chr15

60656722

-
Frame-shiftENST00000309157ENST00000451270RORAchr15

60823965

-ANXA2chr15

60656722

-
Frame-shiftENST00000335670ENST00000332680RORAchr15

60823965

-ANXA2chr15

60656722

-
Frame-shiftENST00000335670ENST00000396024RORAchr15

60823965

-ANXA2chr15

60656722

-
Frame-shiftENST00000335670ENST00000421017RORAchr15

60823965

-ANXA2chr15

60656722

-
Frame-shiftENST00000335670ENST00000451270RORAchr15

60823965

-ANXA2chr15

60656722

-
Frame-shiftENST00000449337ENST00000332680RORAchr15

60823965

-ANXA2chr15

60656722

-
Frame-shiftENST00000449337ENST00000396024RORAchr15

60823965

-ANXA2chr15

60656722

-
Frame-shiftENST00000449337ENST00000421017RORAchr15

60823965

-ANXA2chr15

60656722

-
Frame-shiftENST00000449337ENST00000451270RORAchr15

60823965

-ANXA2chr15

60656722

-
intron-5UTRENST00000261523ENST00000332680RORAchr15

60884585

-ANXA2chr15

60678285

-
intron-5UTRENST00000261523ENST00000332680RORAchr15

61521251

-ANXA2chr15

60678285

-
intron-5UTRENST00000261523ENST00000332680RORAchr15

61521252

-ANXA2chr15

60678285

-
intron-5UTRENST00000261523ENST00000332680RORAchr15

60884586

-ANXA2chr15

60678285

-
intron-5UTRENST00000261523ENST00000332680RORAchr15

60885007

-ANXA2chr15

60678285

-
intron-5UTRENST00000261523ENST00000396024RORAchr15

60884585

-ANXA2chr15

60678285

-
intron-5UTRENST00000261523ENST00000396024RORAchr15

61521251

-ANXA2chr15

60678285

-
intron-5UTRENST00000261523ENST00000396024RORAchr15

61521252

-ANXA2chr15

60678285

-
intron-5UTRENST00000261523ENST00000396024RORAchr15

60884586

-ANXA2chr15

60678285

-
intron-5UTRENST00000261523ENST00000396024RORAchr15

60885007

-ANXA2chr15

60678285

-
intron-5UTRENST00000261523ENST00000421017RORAchr15

60884585

-ANXA2chr15

60678285

-
intron-5UTRENST00000261523ENST00000421017RORAchr15

61521251

-ANXA2chr15

60678285

-
intron-5UTRENST00000261523ENST00000421017RORAchr15

61521252

-ANXA2chr15

60678285

-
intron-5UTRENST00000261523ENST00000421017RORAchr15

60884586

-ANXA2chr15

60678285

-
intron-5UTRENST00000261523ENST00000421017RORAchr15

60885007

-ANXA2chr15

60678285

-
intron-5UTRENST00000261523ENST00000451270RORAchr15

60884585

-ANXA2chr15

60678285

-
intron-5UTRENST00000261523ENST00000451270RORAchr15

61521251

-ANXA2chr15

60678285

-
intron-5UTRENST00000261523ENST00000451270RORAchr15

61521252

-ANXA2chr15

60678285

-
intron-5UTRENST00000261523ENST00000451270RORAchr15

60884586

-ANXA2chr15

60678285

-
intron-5UTRENST00000261523ENST00000451270RORAchr15

60885007

-ANXA2chr15

60678285

-
intron-5UTRENST00000261523ENST00000557937RORAchr15

60884585

-ANXA2chr15

60678285

-
intron-5UTRENST00000261523ENST00000557937RORAchr15

61521251

-ANXA2chr15

60678285

-
intron-5UTRENST00000261523ENST00000557937RORAchr15

61521252

-ANXA2chr15

60678285

-
intron-5UTRENST00000261523ENST00000557937RORAchr15

60884586

-ANXA2chr15

60678285

-
intron-5UTRENST00000261523ENST00000557937RORAchr15

60885007

-ANXA2chr15

60678285

-
intron-5UTRENST00000309157ENST00000332680RORAchr15

60884585

-ANXA2chr15

60678285

-
intron-5UTRENST00000309157ENST00000332680RORAchr15

61521251

-ANXA2chr15

60678285

-
intron-5UTRENST00000309157ENST00000332680RORAchr15

61521252

-ANXA2chr15

60678285

-
intron-5UTRENST00000309157ENST00000332680RORAchr15

60884586

-ANXA2chr15

60678285

-
intron-5UTRENST00000309157ENST00000332680RORAchr15

60885007

-ANXA2chr15

60678285

-
intron-5UTRENST00000309157ENST00000396024RORAchr15

60884585

-ANXA2chr15

60678285

-
intron-5UTRENST00000309157ENST00000396024RORAchr15

61521251

-ANXA2chr15

60678285

-
intron-5UTRENST00000309157ENST00000396024RORAchr15

61521252

-ANXA2chr15

60678285

-
intron-5UTRENST00000309157ENST00000396024RORAchr15

60884586

-ANXA2chr15

60678285

-
intron-5UTRENST00000309157ENST00000396024RORAchr15

60885007

-ANXA2chr15

60678285

-
intron-5UTRENST00000309157ENST00000421017RORAchr15

60884585

-ANXA2chr15

60678285

-
intron-5UTRENST00000309157ENST00000421017RORAchr15

61521251

-ANXA2chr15

60678285

-
intron-5UTRENST00000309157ENST00000421017RORAchr15

61521252

-ANXA2chr15

60678285

-
intron-5UTRENST00000309157ENST00000421017RORAchr15

60884586

-ANXA2chr15

60678285

-
intron-5UTRENST00000309157ENST00000421017RORAchr15

60885007

-ANXA2chr15

60678285

-
intron-5UTRENST00000309157ENST00000451270RORAchr15

60884585

-ANXA2chr15

60678285

-
intron-5UTRENST00000309157ENST00000451270RORAchr15

61521251

-ANXA2chr15

60678285

-
intron-5UTRENST00000309157ENST00000451270RORAchr15

61521252

-ANXA2chr15

60678285

-
intron-5UTRENST00000309157ENST00000451270RORAchr15

60884586

-ANXA2chr15

60678285

-
intron-5UTRENST00000309157ENST00000451270RORAchr15

60885007

-ANXA2chr15

60678285

-
intron-5UTRENST00000309157ENST00000557937RORAchr15

60884585

-ANXA2chr15

60678285

-
intron-5UTRENST00000309157ENST00000557937RORAchr15

61521251

-ANXA2chr15

60678285

-
intron-5UTRENST00000309157ENST00000557937RORAchr15

61521252

-ANXA2chr15

60678285

-
intron-5UTRENST00000309157ENST00000557937RORAchr15

60884586

-ANXA2chr15

60678285

-
intron-5UTRENST00000309157ENST00000557937RORAchr15

60885007

-ANXA2chr15

60678285

-
intron-5UTRENST00000335670ENST00000332680RORAchr15

60884585

-ANXA2chr15

60678285

-
intron-5UTRENST00000335670ENST00000332680RORAchr15

60884586

-ANXA2chr15

60678285

-
intron-5UTRENST00000335670ENST00000332680RORAchr15

60885007

-ANXA2chr15

60678285

-
intron-5UTRENST00000335670ENST00000396024RORAchr15

60884585

-ANXA2chr15

60678285

-
intron-5UTRENST00000335670ENST00000396024RORAchr15

60884586

-ANXA2chr15

60678285

-
intron-5UTRENST00000335670ENST00000396024RORAchr15

60885007

-ANXA2chr15

60678285

-
intron-5UTRENST00000335670ENST00000421017RORAchr15

60884585

-ANXA2chr15

60678285

-
intron-5UTRENST00000335670ENST00000421017RORAchr15

60884586

-ANXA2chr15

60678285

-
intron-5UTRENST00000335670ENST00000421017RORAchr15

60885007

-ANXA2chr15

60678285

-
intron-5UTRENST00000335670ENST00000451270RORAchr15

60884585

-ANXA2chr15

60678285

-
intron-5UTRENST00000335670ENST00000451270RORAchr15

60884586

-ANXA2chr15

60678285

-
intron-5UTRENST00000335670ENST00000451270RORAchr15

60885007

-ANXA2chr15

60678285

-
intron-5UTRENST00000335670ENST00000557937RORAchr15

60884585

-ANXA2chr15

60678285

-
intron-5UTRENST00000335670ENST00000557937RORAchr15

60884586

-ANXA2chr15

60678285

-
intron-5UTRENST00000335670ENST00000557937RORAchr15

60885007

-ANXA2chr15

60678285

-
intron-5UTRENST00000449337ENST00000332680RORAchr15

61521251

-ANXA2chr15

60678285

-
intron-5UTRENST00000449337ENST00000332680RORAchr15

61521252

-ANXA2chr15

60678285

-
intron-5UTRENST00000449337ENST00000332680RORAchr15

60885007

-ANXA2chr15

60678285

-
intron-5UTRENST00000449337ENST00000396024RORAchr15

61521251

-ANXA2chr15

60678285

-
intron-5UTRENST00000449337ENST00000396024RORAchr15

61521252

-ANXA2chr15

60678285

-
intron-5UTRENST00000449337ENST00000396024RORAchr15

60885007

-ANXA2chr15

60678285

-
intron-5UTRENST00000449337ENST00000421017RORAchr15

61521251

-ANXA2chr15

60678285

-
intron-5UTRENST00000449337ENST00000421017RORAchr15

61521252

-ANXA2chr15

60678285

-
intron-5UTRENST00000449337ENST00000421017RORAchr15

60885007

-ANXA2chr15

60678285

-
intron-5UTRENST00000449337ENST00000451270RORAchr15

61521251

-ANXA2chr15

60678285

-
intron-5UTRENST00000449337ENST00000451270RORAchr15

61521252

-ANXA2chr15

60678285

-
intron-5UTRENST00000449337ENST00000451270RORAchr15

60885007

-ANXA2chr15

60678285

-
intron-5UTRENST00000449337ENST00000557937RORAchr15

61521251

-ANXA2chr15

60678285

-
intron-5UTRENST00000449337ENST00000557937RORAchr15

61521252

-ANXA2chr15

60678285

-
intron-5UTRENST00000449337ENST00000557937RORAchr15

60885007

-ANXA2chr15

60678285

-
intron-5UTRENST00000560004ENST00000332680RORAchr15

60884585

-ANXA2chr15

60678285

-
intron-5UTRENST00000560004ENST00000332680RORAchr15

61521251

-ANXA2chr15

60678285

-
intron-5UTRENST00000560004ENST00000332680RORAchr15

61521252

-ANXA2chr15

60678285

-
intron-5UTRENST00000560004ENST00000332680RORAchr15

60884586

-ANXA2chr15

60678285

-
intron-5UTRENST00000560004ENST00000332680RORAchr15

60885007

-ANXA2chr15

60678285

-
intron-5UTRENST00000560004ENST00000396024RORAchr15

60884585

-ANXA2chr15

60678285

-
intron-5UTRENST00000560004ENST00000396024RORAchr15

61521251

-ANXA2chr15

60678285

-
intron-5UTRENST00000560004ENST00000396024RORAchr15

61521252

-ANXA2chr15

60678285

-
intron-5UTRENST00000560004ENST00000396024RORAchr15

60884586

-ANXA2chr15

60678285

-
intron-5UTRENST00000560004ENST00000396024RORAchr15

60885007

-ANXA2chr15

60678285

-
intron-5UTRENST00000560004ENST00000421017RORAchr15

60884585

-ANXA2chr15

60678285

-
intron-5UTRENST00000560004ENST00000421017RORAchr15

61521251

-ANXA2chr15

60678285

-
intron-5UTRENST00000560004ENST00000421017RORAchr15

61521252

-ANXA2chr15

60678285

-
intron-5UTRENST00000560004ENST00000421017RORAchr15

60884586

-ANXA2chr15

60678285

-
intron-5UTRENST00000560004ENST00000421017RORAchr15

60885007

-ANXA2chr15

60678285

-
intron-5UTRENST00000560004ENST00000451270RORAchr15

60884585

-ANXA2chr15

60678285

-
intron-5UTRENST00000560004ENST00000451270RORAchr15

61521251

-ANXA2chr15

60678285

-
intron-5UTRENST00000560004ENST00000451270RORAchr15

61521252

-ANXA2chr15

60678285

-
intron-5UTRENST00000560004ENST00000451270RORAchr15

60884586

-ANXA2chr15

60678285

-
intron-5UTRENST00000560004ENST00000451270RORAchr15

60885007

-ANXA2chr15

60678285

-
intron-5UTRENST00000560004ENST00000557937RORAchr15

60884585

-ANXA2chr15

60678285

-
intron-5UTRENST00000560004ENST00000557937RORAchr15

61521251

-ANXA2chr15

60678285

-
intron-5UTRENST00000560004ENST00000557937RORAchr15

61521252

-ANXA2chr15

60678285

-
intron-5UTRENST00000560004ENST00000557937RORAchr15

60884586

-ANXA2chr15

60678285

-
intron-5UTRENST00000560004ENST00000557937RORAchr15

60885007

-ANXA2chr15

60678285

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for RORA-ANXA2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RORA-ANXA2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:60884585/:60678285)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ANXA2

A6NMY6

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for RORA-ANXA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for RORA-ANXA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RORA-ANXA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RORA-ANXA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource