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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ATG2A-EFCAB6 (FusionGDB2 ID:7542)

Fusion Gene Summary for ATG2A-EFCAB6

Fusion gene summary

Fusion gene information	Fusion gene name: ATG2A-EFCAB6
	Fusion gene ID: 7542
		Hgene	Tgene
	Gene symbol	ATG2A	EFCAB6
	Gene ID	23130	64800
	Gene name	autophagy related 2A	EF-hand calcium binding domain 6
	Synonyms	-	DJBP\|HSCBCIP1\|dJ185D5.1
	Cytomap	11q13.1	22q13.2-q13.31
	Type of gene	protein-coding	protein-coding
	Description	autophagy-related protein 2 homolog AATG2 autophagy related 2 homolog A	EF-hand calcium-binding domain-containing protein 6CAP-binding protein complex-interacting protein 1DJ-1-binding proteinepididymis secretory sperm binding protein
	Modification date	20200313	20200313
	UniProtAcc	Q2TAZ0	Q5THR3
	Ensembl transtripts involved in fusion gene	ENST00000377264, ENST00000421419,	ENST00000461800, ENST00000356087, ENST00000358439, ENST00000262726, ENST00000396231,
Fusion gene scores	* DoF score	7 X 10 X 7=490	29 X 21 X 6=3654
	# samples	8	31
	** MAII score	log2(8/490*10)=-2.61470984411521 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(31/3654*10)=-3.55913651335325 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ATG2A [Title/Abstract] AND EFCAB6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ATG2A(64680510)-EFCAB6(43936237), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ATG2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EFCAB6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	KIRC	TCGA-BP-4173-01A	ATG2A	chr11	64680510	-	EFCAB6	chr22	43936237	-

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Fusion Gene ORF analysis for ATG2A-EFCAB6

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000377264	ENST00000461800	ATG2A	chr11	64680510	-	EFCAB6	chr22	43936237	-
5CDS-5UTR	ENST00000421419	ENST00000461800	ATG2A	chr11	64680510	-	EFCAB6	chr22	43936237	-
5CDS-intron	ENST00000377264	ENST00000356087	ATG2A	chr11	64680510	-	EFCAB6	chr22	43936237	-
5CDS-intron	ENST00000377264	ENST00000358439	ATG2A	chr11	64680510	-	EFCAB6	chr22	43936237	-
5CDS-intron	ENST00000421419	ENST00000356087	ATG2A	chr11	64680510	-	EFCAB6	chr22	43936237	-
5CDS-intron	ENST00000421419	ENST00000358439	ATG2A	chr11	64680510	-	EFCAB6	chr22	43936237	-
In-frame	ENST00000377264	ENST00000262726	ATG2A	chr11	64680510	-	EFCAB6	chr22	43936237	-
In-frame	ENST00000377264	ENST00000396231	ATG2A	chr11	64680510	-	EFCAB6	chr22	43936237	-
In-frame	ENST00000421419	ENST00000262726	ATG2A	chr11	64680510	-	EFCAB6	chr22	43936237	-
In-frame	ENST00000421419	ENST00000396231	ATG2A	chr11	64680510	-	EFCAB6	chr22	43936237	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000421419	ATG2A	chr11	64680510	-	ENST00000396231	EFCAB6	chr22	43936237	-	1907	940	115	1797	560
ENST00000421419	ATG2A	chr11	64680510	-	ENST00000262726	EFCAB6	chr22	43936237	-	1907	940	115	1797	560
ENST00000377264	ATG2A	chr11	64680510	-	ENST00000396231	EFCAB6	chr22	43936237	-	1905	938	113	1795	560
ENST00000377264	ATG2A	chr11	64680510	-	ENST00000262726	EFCAB6	chr22	43936237	-	1905	938	113	1795	560

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000421419	ENST00000396231	ATG2A	chr11	64680510	-	EFCAB6	chr22	43936237	-	0.0338858	0.96611416
ENST00000421419	ENST00000262726	ATG2A	chr11	64680510	-	EFCAB6	chr22	43936237	-	0.0338858	0.96611416
ENST00000377264	ENST00000396231	ATG2A	chr11	64680510	-	EFCAB6	chr22	43936237	-	0.033729	0.966271
ENST00000377264	ENST00000262726	ATG2A	chr11	64680510	-	EFCAB6	chr22	43936237	-	0.033729	0.966271

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Fusion Genomic Features for ATG2A-EFCAB6

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ATG2A-EFCAB6

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:64680510/chr22:43936237)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ATG2A Q2TAZ0	EFCAB6 Q5THR3
FUNCTION: Involved in autophagosome assembly, regulating the size of nascent autophagosomes (PubMed:28561066). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (By similarity). {ECO:0000250\|UniProtKB:Q96BY7, ECO:0000269\|PubMed:22219374, ECO:0000269\|PubMed:28561066}.	FUNCTION: Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex. {ECO:0000269\|PubMed:12612053}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000262726

1359_1394

1216

1502.0

Domain

EF-hand 15

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000262726

1434_1469

1216

1502.0

Domain

EF-hand 16

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000262726

1470_1501

1216

1502.0

Domain

EF-hand 17

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000396231

1069_1104

1064

1350.0

Domain

EF-hand 12

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000396231

1176_1211

1064

1350.0

Domain

EF-hand 13

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000396231

1212_1247

1064

1350.0

Domain

EF-hand 14

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000396231

1359_1394

1064

1350.0

Domain

EF-hand 15

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000396231

1434_1469

1064

1350.0

Domain

EF-hand 16

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000396231

1470_1501

1064

1350.0

Domain

EF-hand 17

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000262726

754_765

1216

1502.0

Calcium binding

Ontology_term=ECO:0000255

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000396231

754_765

1064

1350.0

Calcium binding

Ontology_term=ECO:0000255

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000262726

1069_1104

1216

1502.0

Domain

EF-hand 12

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000262726

1176_1211

1216

1502.0

Domain

EF-hand 13

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000262726

1212_1247

1216

1502.0

Domain

EF-hand 14

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000262726

172_207

1216

1502.0

Domain

EF-hand 2

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000262726

297_332

1216

1502.0

Domain

EF-hand 3

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000262726

403_438

1216

1502.0

Domain

EF-hand 4

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000262726

439_474

1216

1502.0

Domain

EF-hand 5

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000262726

504_539

1216

1502.0

Domain

EF-hand 6

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000262726

634_669

1216

1502.0

Domain

EF-hand 7

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000262726

70_105

1216

1502.0

Domain

EF-hand 1

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000262726

741_776

1216

1502.0

Domain

EF-hand 8

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000262726

847_882

1216

1502.0

Domain

EF-hand 9

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000262726

883_918

1216

1502.0

Domain

EF-hand 10

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000262726

964_999

1216

1502.0

Domain

EF-hand 11

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000396231

172_207

1064

1350.0

Domain

EF-hand 2

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000396231

297_332

1064

1350.0

Domain

EF-hand 3

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000396231

403_438

1064

1350.0

Domain

EF-hand 4

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000396231

439_474

1064

1350.0

Domain

EF-hand 5

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000396231

504_539

1064

1350.0

Domain

EF-hand 6

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000396231

634_669

1064

1350.0

Domain

EF-hand 7

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000396231

70_105

1064

1350.0

Domain

EF-hand 1

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000396231

741_776

1064

1350.0

Domain

EF-hand 8

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000396231

847_882

1064

1350.0

Domain

EF-hand 9

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000396231

883_918

1064

1350.0

Domain

EF-hand 10

Tgene

EFCAB6

chr11:64680510

chr22:43936237

ENST00000396231

964_999

1064

1350.0

Domain

EF-hand 11

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Fusion Gene Sequence for ATG2A-EFCAB6

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>7542_7542_1_ATG2A-EFCAB6_ATG2A_chr11_64680510_ENST00000377264_EFCAB6_chr22_43936237_ENST00000262726_length(transcript)=1905nt_BP=938nt
CTGGCGCCTAGAGAAGCGGCGGGGCGAGCCGGGGGCTCTAGTGAACAGCGGAGCCGGACGGGGATCGCCGGCGGGCGGCAAGCGGAGGCG
GCCCAGGCCCGGCGGTCTCCGAGATGTCACGATGGCTGTGGCCATGGTCAAACTGTGTGAAAGAGCGGGTCTGCCGCTACTTGCTGCACC
ACTACTTAGGTCACTTCTTCCAAGAGCACCTCAGCCTGGACCAGCTCAGCCTCGATCTGTACAAGGGCAGCGTTGCCCTGCGAGACATCC
ACCTGGAAATCTGGTCTGTGAACGAGGTGCTGGAGTCAATGGAGTCACCGCTGGAGCTGGTGGAAGGCTTCGTGGGCTCCATCGAGGTGG
CCGTGCCCTGGGCTGCTCTGCTCACCGACCACTGCACAGTGCGCGTGTCCGGCCTCCAGCTCACCTTGCAGCCCCGCCGGGGTCCAGCGC
CAGGGGCTGCCGACTCACAGAGCTGGGCCTCATGCATGACCACAAGCCTGCAGCTGGCCCAGGAGTGTCTGCGGGATGGGCTACCGGAGC
CCTCTGAGCCACCACAGCCCCTGGAGGGGCTGGAGATGTTTGCCCAGACCATTGAGACTGTGCTTCGGAGGATCAAAGTGACCTTCCTGG
ACACTGTCGTGAGGGTGGAGCACTCTCCGGGTGATGGGGAACGTGGTGTGGCCGTCGAGGTCCGTGTGCAGAGACTGGAGTACTGTGATG
AGGCAGTGCGGGACCCAAGCCAGGCGCCGCCGGTGGACGTGCATCAGCCGCCTGCCTTCCTGCACAAGCTGCTGCAGCTGGCAGGGGTCC
GCCTGCACTACGAGGAGCTCCCGGCACAGGAAGAGCCTCCAGAGCCCCCCTTGCAGATCGGCAGCTGCTCAGGGTACATGGAGCTGATGG
TGAAGTTGAAGCAAAATGAGGCCTTCCCTGGCCCCAAGTTTGACAGACTCTGGAACGAGATGCCAGTCAATGCCAAGGGGAGGCTGAAAT
ACCCGGACTTCCTGAGCAGGTTCAGTTCCGAGACAGCAGCCACACCAATGGCCACTGGTGACTCGGCCGTGGCCCAGAGAGGGAGCAGTG
TCCCTGACGTCTCGGAAGGCACCAGATCTGCCCTCTCATTGCCCACTCAGGAGCTGAGACCAGGGTCAAAGTCGCAGAGCCACCCCTGTA
CTCCAGCGAGCACCACCGTGATCCCGGGCACTCCACCCTTGCAGAACTGTGATCCCATAGAGAGCAGGCTCCGGAAGAGAATCCAGGGCT
GCTGGCGCCAGCTCCTGAAAGAATGCAAGGAGAAGGACGTGGCCAGACAGGGGGACATCAACGCCTCCGATTTCCTGGCTCTTGTGGAGA
AATTCAACCTGGACATAAGCAAAGAGGAGTGTCAGCAGCTCATTATAAAATACGACTTAAAGAGCAACGGGAAATTTGCATACTGTGACT
TCATTCAGAGCTGTGTCCTCCTGCTAAAAGCAAAGGAAAGCTCACTGATGCACAGGATGAAGATCCAGAATGCACACAAGATGAAAGAAG
CCGGCGCGGAGACGCCATCTTTTTACTCTGCTCTGCTGCGTATTCAGCCCAAAATTGTGCACTGCTGGAGGCCAATGCGGCGCACGTTCA
AAAGCTATGATGAGGCTGGAACAGGGCTGCTAAGCGTCGCAGATTTCAGGACGGTCCTGAGACAGTACAGCATCAACCTCTCTGAGGAAG
AGTTCTTCCATATTCTGGAGTATTACGATAAGACGCTGTCTTCAAAAATCTCCTACAACGACTTCCTCCGGGCATTCCTCCAGTAGACAC
CCCTGCTGTGTGCCCAGCGGGACGACAGCCACAGGGCCTGTTTCAAGGCTAATAAAATCCTATAATTTGGGGGTTTCATGAATTTTCAAA

>7542_7542_1_ATG2A-EFCAB6_ATG2A_chr11_64680510_ENST00000377264_EFCAB6_chr22_43936237_ENST00000262726_length(amino acids)=560AA_BP=275
MSRWLWPWSNCVKERVCRYLLHHYLGHFFQEHLSLDQLSLDLYKGSVALRDIHLEIWSVNEVLESMESPLELVEGFVGSIEVAVPWAALL
TDHCTVRVSGLQLTLQPRRGPAPGAADSQSWASCMTTSLQLAQECLRDGLPEPSEPPQPLEGLEMFAQTIETVLRRIKVTFLDTVVRVEH
SPGDGERGVAVEVRVQRLEYCDEAVRDPSQAPPVDVHQPPAFLHKLLQLAGVRLHYEELPAQEEPPEPPLQIGSCSGYMELMVKLKQNEA
FPGPKFDRLWNEMPVNAKGRLKYPDFLSRFSSETAATPMATGDSAVAQRGSSVPDVSEGTRSALSLPTQELRPGSKSQSHPCTPASTTVI
PGTPPLQNCDPIESRLRKRIQGCWRQLLKECKEKDVARQGDINASDFLALVEKFNLDISKEECQQLIIKYDLKSNGKFAYCDFIQSCVLL
LKAKESSLMHRMKIQNAHKMKEAGAETPSFYSALLRIQPKIVHCWRPMRRTFKSYDEAGTGLLSVADFRTVLRQYSINLSEEEFFHILEY

--------------------------------------------------------------
>7542_7542_2_ATG2A-EFCAB6_ATG2A_chr11_64680510_ENST00000377264_EFCAB6_chr22_43936237_ENST00000396231_length(transcript)=1905nt_BP=938nt
CTGGCGCCTAGAGAAGCGGCGGGGCGAGCCGGGGGCTCTAGTGAACAGCGGAGCCGGACGGGGATCGCCGGCGGGCGGCAAGCGGAGGCG
GCCCAGGCCCGGCGGTCTCCGAGATGTCACGATGGCTGTGGCCATGGTCAAACTGTGTGAAAGAGCGGGTCTGCCGCTACTTGCTGCACC
ACTACTTAGGTCACTTCTTCCAAGAGCACCTCAGCCTGGACCAGCTCAGCCTCGATCTGTACAAGGGCAGCGTTGCCCTGCGAGACATCC
ACCTGGAAATCTGGTCTGTGAACGAGGTGCTGGAGTCAATGGAGTCACCGCTGGAGCTGGTGGAAGGCTTCGTGGGCTCCATCGAGGTGG
CCGTGCCCTGGGCTGCTCTGCTCACCGACCACTGCACAGTGCGCGTGTCCGGCCTCCAGCTCACCTTGCAGCCCCGCCGGGGTCCAGCGC
CAGGGGCTGCCGACTCACAGAGCTGGGCCTCATGCATGACCACAAGCCTGCAGCTGGCCCAGGAGTGTCTGCGGGATGGGCTACCGGAGC
CCTCTGAGCCACCACAGCCCCTGGAGGGGCTGGAGATGTTTGCCCAGACCATTGAGACTGTGCTTCGGAGGATCAAAGTGACCTTCCTGG
ACACTGTCGTGAGGGTGGAGCACTCTCCGGGTGATGGGGAACGTGGTGTGGCCGTCGAGGTCCGTGTGCAGAGACTGGAGTACTGTGATG
AGGCAGTGCGGGACCCAAGCCAGGCGCCGCCGGTGGACGTGCATCAGCCGCCTGCCTTCCTGCACAAGCTGCTGCAGCTGGCAGGGGTCC
GCCTGCACTACGAGGAGCTCCCGGCACAGGAAGAGCCTCCAGAGCCCCCCTTGCAGATCGGCAGCTGCTCAGGGTACATGGAGCTGATGG
TGAAGTTGAAGCAAAATGAGGCCTTCCCTGGCCCCAAGTTTGACAGACTCTGGAACGAGATGCCAGTCAATGCCAAGGGGAGGCTGAAAT
ACCCGGACTTCCTGAGCAGGTTCAGTTCCGAGACAGCAGCCACACCAATGGCCACTGGTGACTCGGCCGTGGCCCAGAGAGGGAGCAGTG
TCCCTGACGTCTCGGAAGGCACCAGATCTGCCCTCTCATTGCCCACTCAGGAGCTGAGACCAGGGTCAAAGTCGCAGAGCCACCCCTGTA
CTCCAGCGAGCACCACCGTGATCCCGGGCACTCCACCCTTGCAGAACTGTGATCCCATAGAGAGCAGGCTCCGGAAGAGAATCCAGGGCT
GCTGGCGCCAGCTCCTGAAAGAATGCAAGGAGAAGGACGTGGCCAGACAGGGGGACATCAACGCCTCCGATTTCCTGGCTCTTGTGGAGA
AATTCAACCTGGACATAAGCAAAGAGGAGTGTCAGCAGCTCATTATAAAATACGACTTAAAGAGCAACGGGAAATTTGCATACTGTGACT
TCATTCAGAGCTGTGTCCTCCTGCTAAAAGCAAAGGAAAGCTCACTGATGCACAGGATGAAGATCCAGAATGCACACAAGATGAAAGAAG
CCGGCGCGGAGACGCCATCTTTTTACTCTGCTCTGCTGCGTATTCAGCCCAAAATTGTGCACTGCTGGAGGCCAATGCGGCGCACGTTCA
AAAGCTATGATGAGGCTGGAACAGGGCTGCTAAGCGTCGCAGATTTCAGGACGGTCCTGAGACAGTACAGCATCAACCTCTCTGAGGAAG
AGTTCTTCCATATTCTGGAGTATTACGATAAGACGCTGTCTTCAAAAATCTCCTACAACGACTTCCTCCGGGCATTCCTCCAGTAGACAC
CCCTGCTGTGTGCCCAGCGGGACGACAGCCACAGGGCCTGTTTCAAGGCTAATAAAATCCTATAATTTGGGGGTTTCATGAATTTTCAAA

>7542_7542_2_ATG2A-EFCAB6_ATG2A_chr11_64680510_ENST00000377264_EFCAB6_chr22_43936237_ENST00000396231_length(amino acids)=560AA_BP=275
MSRWLWPWSNCVKERVCRYLLHHYLGHFFQEHLSLDQLSLDLYKGSVALRDIHLEIWSVNEVLESMESPLELVEGFVGSIEVAVPWAALL
TDHCTVRVSGLQLTLQPRRGPAPGAADSQSWASCMTTSLQLAQECLRDGLPEPSEPPQPLEGLEMFAQTIETVLRRIKVTFLDTVVRVEH
SPGDGERGVAVEVRVQRLEYCDEAVRDPSQAPPVDVHQPPAFLHKLLQLAGVRLHYEELPAQEEPPEPPLQIGSCSGYMELMVKLKQNEA
FPGPKFDRLWNEMPVNAKGRLKYPDFLSRFSSETAATPMATGDSAVAQRGSSVPDVSEGTRSALSLPTQELRPGSKSQSHPCTPASTTVI
PGTPPLQNCDPIESRLRKRIQGCWRQLLKECKEKDVARQGDINASDFLALVEKFNLDISKEECQQLIIKYDLKSNGKFAYCDFIQSCVLL
LKAKESSLMHRMKIQNAHKMKEAGAETPSFYSALLRIQPKIVHCWRPMRRTFKSYDEAGTGLLSVADFRTVLRQYSINLSEEEFFHILEY

--------------------------------------------------------------
>7542_7542_3_ATG2A-EFCAB6_ATG2A_chr11_64680510_ENST00000421419_EFCAB6_chr22_43936237_ENST00000262726_length(transcript)=1907nt_BP=940nt
GCCTGGCGCCTAGAGAAGCGGCGGGGCGAGCCGGGGGCTCTAGTGAACAGCGGAGCCGGACGGGGATCGCCGGCGGGCGGCAAGCGGAGG
CGGCCCAGGCCCGGCGGTCTCCGAGATGTCACGATGGCTGTGGCCATGGTCAAACTGTGTGAAAGAGCGGGTCTGCCGCTACTTGCTGCA
CCACTACTTAGGTCACTTCTTCCAAGAGCACCTCAGCCTGGACCAGCTCAGCCTCGATCTGTACAAGGGCAGCGTTGCCCTGCGAGACAT
CCACCTGGAAATCTGGTCTGTGAACGAGGTGCTGGAGTCAATGGAGTCACCGCTGGAGCTGGTGGAAGGCTTCGTGGGCTCCATCGAGGT
GGCCGTGCCCTGGGCTGCTCTGCTCACCGACCACTGCACAGTGCGCGTGTCCGGCCTCCAGCTCACCTTGCAGCCCCGCCGGGGTCCAGC
GCCAGGGGCTGCCGACTCACAGAGCTGGGCCTCATGCATGACCACAAGCCTGCAGCTGGCCCAGGAGTGTCTGCGGGATGGGCTACCGGA
GCCCTCTGAGCCACCACAGCCCCTGGAGGGGCTGGAGATGTTTGCCCAGACCATTGAGACTGTGCTTCGGAGGATCAAAGTGACCTTCCT
GGACACTGTCGTGAGGGTGGAGCACTCTCCGGGTGATGGGGAACGTGGTGTGGCCGTCGAGGTCCGTGTGCAGAGACTGGAGTACTGTGA
TGAGGCAGTGCGGGACCCAAGCCAGGCGCCGCCGGTGGACGTGCATCAGCCGCCTGCCTTCCTGCACAAGCTGCTGCAGCTGGCAGGGGT
CCGCCTGCACTACGAGGAGCTCCCGGCACAGGAAGAGCCTCCAGAGCCCCCCTTGCAGATCGGCAGCTGCTCAGGGTACATGGAGCTGAT
GGTGAAGTTGAAGCAAAATGAGGCCTTCCCTGGCCCCAAGTTTGACAGACTCTGGAACGAGATGCCAGTCAATGCCAAGGGGAGGCTGAA
ATACCCGGACTTCCTGAGCAGGTTCAGTTCCGAGACAGCAGCCACACCAATGGCCACTGGTGACTCGGCCGTGGCCCAGAGAGGGAGCAG
TGTCCCTGACGTCTCGGAAGGCACCAGATCTGCCCTCTCATTGCCCACTCAGGAGCTGAGACCAGGGTCAAAGTCGCAGAGCCACCCCTG
TACTCCAGCGAGCACCACCGTGATCCCGGGCACTCCACCCTTGCAGAACTGTGATCCCATAGAGAGCAGGCTCCGGAAGAGAATCCAGGG
CTGCTGGCGCCAGCTCCTGAAAGAATGCAAGGAGAAGGACGTGGCCAGACAGGGGGACATCAACGCCTCCGATTTCCTGGCTCTTGTGGA
GAAATTCAACCTGGACATAAGCAAAGAGGAGTGTCAGCAGCTCATTATAAAATACGACTTAAAGAGCAACGGGAAATTTGCATACTGTGA
CTTCATTCAGAGCTGTGTCCTCCTGCTAAAAGCAAAGGAAAGCTCACTGATGCACAGGATGAAGATCCAGAATGCACACAAGATGAAAGA
AGCCGGCGCGGAGACGCCATCTTTTTACTCTGCTCTGCTGCGTATTCAGCCCAAAATTGTGCACTGCTGGAGGCCAATGCGGCGCACGTT
CAAAAGCTATGATGAGGCTGGAACAGGGCTGCTAAGCGTCGCAGATTTCAGGACGGTCCTGAGACAGTACAGCATCAACCTCTCTGAGGA
AGAGTTCTTCCATATTCTGGAGTATTACGATAAGACGCTGTCTTCAAAAATCTCCTACAACGACTTCCTCCGGGCATTCCTCCAGTAGAC
ACCCCTGCTGTGTGCCCAGCGGGACGACAGCCACAGGGCCTGTTTCAAGGCTAATAAAATCCTATAATTTGGGGGTTTCATGAATTTTCA

>7542_7542_3_ATG2A-EFCAB6_ATG2A_chr11_64680510_ENST00000421419_EFCAB6_chr22_43936237_ENST00000262726_length(amino acids)=560AA_BP=275
MSRWLWPWSNCVKERVCRYLLHHYLGHFFQEHLSLDQLSLDLYKGSVALRDIHLEIWSVNEVLESMESPLELVEGFVGSIEVAVPWAALL
TDHCTVRVSGLQLTLQPRRGPAPGAADSQSWASCMTTSLQLAQECLRDGLPEPSEPPQPLEGLEMFAQTIETVLRRIKVTFLDTVVRVEH
SPGDGERGVAVEVRVQRLEYCDEAVRDPSQAPPVDVHQPPAFLHKLLQLAGVRLHYEELPAQEEPPEPPLQIGSCSGYMELMVKLKQNEA
FPGPKFDRLWNEMPVNAKGRLKYPDFLSRFSSETAATPMATGDSAVAQRGSSVPDVSEGTRSALSLPTQELRPGSKSQSHPCTPASTTVI
PGTPPLQNCDPIESRLRKRIQGCWRQLLKECKEKDVARQGDINASDFLALVEKFNLDISKEECQQLIIKYDLKSNGKFAYCDFIQSCVLL
LKAKESSLMHRMKIQNAHKMKEAGAETPSFYSALLRIQPKIVHCWRPMRRTFKSYDEAGTGLLSVADFRTVLRQYSINLSEEEFFHILEY

--------------------------------------------------------------
>7542_7542_4_ATG2A-EFCAB6_ATG2A_chr11_64680510_ENST00000421419_EFCAB6_chr22_43936237_ENST00000396231_length(transcript)=1907nt_BP=940nt
GCCTGGCGCCTAGAGAAGCGGCGGGGCGAGCCGGGGGCTCTAGTGAACAGCGGAGCCGGACGGGGATCGCCGGCGGGCGGCAAGCGGAGG
CGGCCCAGGCCCGGCGGTCTCCGAGATGTCACGATGGCTGTGGCCATGGTCAAACTGTGTGAAAGAGCGGGTCTGCCGCTACTTGCTGCA
CCACTACTTAGGTCACTTCTTCCAAGAGCACCTCAGCCTGGACCAGCTCAGCCTCGATCTGTACAAGGGCAGCGTTGCCCTGCGAGACAT
CCACCTGGAAATCTGGTCTGTGAACGAGGTGCTGGAGTCAATGGAGTCACCGCTGGAGCTGGTGGAAGGCTTCGTGGGCTCCATCGAGGT
GGCCGTGCCCTGGGCTGCTCTGCTCACCGACCACTGCACAGTGCGCGTGTCCGGCCTCCAGCTCACCTTGCAGCCCCGCCGGGGTCCAGC
GCCAGGGGCTGCCGACTCACAGAGCTGGGCCTCATGCATGACCACAAGCCTGCAGCTGGCCCAGGAGTGTCTGCGGGATGGGCTACCGGA
GCCCTCTGAGCCACCACAGCCCCTGGAGGGGCTGGAGATGTTTGCCCAGACCATTGAGACTGTGCTTCGGAGGATCAAAGTGACCTTCCT
GGACACTGTCGTGAGGGTGGAGCACTCTCCGGGTGATGGGGAACGTGGTGTGGCCGTCGAGGTCCGTGTGCAGAGACTGGAGTACTGTGA
TGAGGCAGTGCGGGACCCAAGCCAGGCGCCGCCGGTGGACGTGCATCAGCCGCCTGCCTTCCTGCACAAGCTGCTGCAGCTGGCAGGGGT
CCGCCTGCACTACGAGGAGCTCCCGGCACAGGAAGAGCCTCCAGAGCCCCCCTTGCAGATCGGCAGCTGCTCAGGGTACATGGAGCTGAT
GGTGAAGTTGAAGCAAAATGAGGCCTTCCCTGGCCCCAAGTTTGACAGACTCTGGAACGAGATGCCAGTCAATGCCAAGGGGAGGCTGAA
ATACCCGGACTTCCTGAGCAGGTTCAGTTCCGAGACAGCAGCCACACCAATGGCCACTGGTGACTCGGCCGTGGCCCAGAGAGGGAGCAG
TGTCCCTGACGTCTCGGAAGGCACCAGATCTGCCCTCTCATTGCCCACTCAGGAGCTGAGACCAGGGTCAAAGTCGCAGAGCCACCCCTG
TACTCCAGCGAGCACCACCGTGATCCCGGGCACTCCACCCTTGCAGAACTGTGATCCCATAGAGAGCAGGCTCCGGAAGAGAATCCAGGG
CTGCTGGCGCCAGCTCCTGAAAGAATGCAAGGAGAAGGACGTGGCCAGACAGGGGGACATCAACGCCTCCGATTTCCTGGCTCTTGTGGA
GAAATTCAACCTGGACATAAGCAAAGAGGAGTGTCAGCAGCTCATTATAAAATACGACTTAAAGAGCAACGGGAAATTTGCATACTGTGA
CTTCATTCAGAGCTGTGTCCTCCTGCTAAAAGCAAAGGAAAGCTCACTGATGCACAGGATGAAGATCCAGAATGCACACAAGATGAAAGA
AGCCGGCGCGGAGACGCCATCTTTTTACTCTGCTCTGCTGCGTATTCAGCCCAAAATTGTGCACTGCTGGAGGCCAATGCGGCGCACGTT
CAAAAGCTATGATGAGGCTGGAACAGGGCTGCTAAGCGTCGCAGATTTCAGGACGGTCCTGAGACAGTACAGCATCAACCTCTCTGAGGA
AGAGTTCTTCCATATTCTGGAGTATTACGATAAGACGCTGTCTTCAAAAATCTCCTACAACGACTTCCTCCGGGCATTCCTCCAGTAGAC
ACCCCTGCTGTGTGCCCAGCGGGACGACAGCCACAGGGCCTGTTTCAAGGCTAATAAAATCCTATAATTTGGGGGTTTCATGAATTTTCA

>7542_7542_4_ATG2A-EFCAB6_ATG2A_chr11_64680510_ENST00000421419_EFCAB6_chr22_43936237_ENST00000396231_length(amino acids)=560AA_BP=275
MSRWLWPWSNCVKERVCRYLLHHYLGHFFQEHLSLDQLSLDLYKGSVALRDIHLEIWSVNEVLESMESPLELVEGFVGSIEVAVPWAALL
TDHCTVRVSGLQLTLQPRRGPAPGAADSQSWASCMTTSLQLAQECLRDGLPEPSEPPQPLEGLEMFAQTIETVLRRIKVTFLDTVVRVEH
SPGDGERGVAVEVRVQRLEYCDEAVRDPSQAPPVDVHQPPAFLHKLLQLAGVRLHYEELPAQEEPPEPPLQIGSCSGYMELMVKLKQNEA
FPGPKFDRLWNEMPVNAKGRLKYPDFLSRFSSETAATPMATGDSAVAQRGSSVPDVSEGTRSALSLPTQELRPGSKSQSHPCTPASTTVI
PGTPPLQNCDPIESRLRKRIQGCWRQLLKECKEKDVARQGDINASDFLALVEKFNLDISKEECQQLIIKYDLKSNGKFAYCDFIQSCVLL
LKAKESSLMHRMKIQNAHKMKEAGAETPSFYSALLRIQPKIVHCWRPMRRTFKSYDEAGTGLLSVADFRTVLRQYSINLSEEEFFHILEY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ATG2A-EFCAB6

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	EFCAB6	chr11:64680510	chr22:43936237	ENST00000262726		26	32	1407_1501	1216.0	1502.0	AR
Tgene	EFCAB6	chr11:64680510	chr22:43936237	ENST00000396231		24	30	1407_1501	1064.0	1350.0	AR
Tgene	EFCAB6	chr11:64680510	chr22:43936237	ENST00000262726		26	32	1303_1501	1216.0	1502.0	PARK7
Tgene	EFCAB6	chr11:64680510	chr22:43936237	ENST00000396231		24	30	1303_1501	1064.0	1350.0	PARK7

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ATG2A-EFCAB6

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ATG2A-EFCAB6

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source