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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RPL10-GNB2 (FusionGDB2 ID:75768)

Fusion Gene Summary for RPL10-GNB2

check button Fusion gene summary
Fusion gene informationFusion gene name: RPL10-GNB2
Fusion gene ID: 75768
HgeneTgene
Gene symbol

RPL10

GNB2

Gene ID

6138

2783

Gene nameribosomal protein L15G protein subunit beta 2
SynonymsDBA12|EC45|L15|RPL10|RPLY10|RPYL10-
Cytomap

3p24.2

7q22.1

Type of geneprotein-codingprotein-coding
Description60S ribosomal protein L15large ribosomal subunit protein eL15guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2G protein, beta-2 subunitepididymis secretory sperm binding proteing protein subunit beta-2guanine nucleotide binding protein (G protein), beta polypeptide 2guanine nucleotide-binding pr
Modification date2020031320200313
UniProtAcc.

P62879

Ensembl transtripts involved in fusion geneENST00000479366, ENST00000369817, 
ENST00000424325, ENST00000406022, 
ENST00000303210, ENST00000424361, 
ENST00000436220, ENST00000419828, 
ENST00000393924, ENST00000393926, 
ENST00000427895, 
Fusion gene scores* DoF score11 X 12 X 7=9246 X 7 X 2=84
# samples 177
** MAII scorelog2(17/924*10)=-2.44235810527836
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPL10 [Title/Abstract] AND GNB2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRPL10(153626883)-GNB2(100274974), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RPL10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GNB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8531RPL10chrX

153626883

+GNB2chr7

100274974

+


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Fusion Gene ORF analysis for RPL10-GNB2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000479366ENST00000303210RPL10chrX

153626883

+GNB2chr7

100274974

+
3UTR-3CDSENST00000479366ENST00000424361RPL10chrX

153626883

+GNB2chr7

100274974

+
3UTR-3CDSENST00000479366ENST00000436220RPL10chrX

153626883

+GNB2chr7

100274974

+
3UTR-5UTRENST00000479366ENST00000419828RPL10chrX

153626883

+GNB2chr7

100274974

+
3UTR-intronENST00000479366ENST00000393924RPL10chrX

153626883

+GNB2chr7

100274974

+
3UTR-intronENST00000479366ENST00000393926RPL10chrX

153626883

+GNB2chr7

100274974

+
3UTR-intronENST00000479366ENST00000427895RPL10chrX

153626883

+GNB2chr7

100274974

+
5CDS-5UTRENST00000369817ENST00000419828RPL10chrX

153626883

+GNB2chr7

100274974

+
5CDS-5UTRENST00000424325ENST00000419828RPL10chrX

153626883

+GNB2chr7

100274974

+
5CDS-intronENST00000369817ENST00000393924RPL10chrX

153626883

+GNB2chr7

100274974

+
5CDS-intronENST00000369817ENST00000393926RPL10chrX

153626883

+GNB2chr7

100274974

+
5CDS-intronENST00000369817ENST00000427895RPL10chrX

153626883

+GNB2chr7

100274974

+
5CDS-intronENST00000424325ENST00000393924RPL10chrX

153626883

+GNB2chr7

100274974

+
5CDS-intronENST00000424325ENST00000393926RPL10chrX

153626883

+GNB2chr7

100274974

+
5CDS-intronENST00000424325ENST00000427895RPL10chrX

153626883

+GNB2chr7

100274974

+
In-frameENST00000369817ENST00000303210RPL10chrX

153626883

+GNB2chr7

100274974

+
In-frameENST00000369817ENST00000424361RPL10chrX

153626883

+GNB2chr7

100274974

+
In-frameENST00000369817ENST00000436220RPL10chrX

153626883

+GNB2chr7

100274974

+
In-frameENST00000424325ENST00000303210RPL10chrX

153626883

+GNB2chr7

100274974

+
In-frameENST00000424325ENST00000424361RPL10chrX

153626883

+GNB2chr7

100274974

+
In-frameENST00000424325ENST00000436220RPL10chrX

153626883

+GNB2chr7

100274974

+
intron-3CDSENST00000406022ENST00000303210RPL10chrX

153626883

+GNB2chr7

100274974

+
intron-3CDSENST00000406022ENST00000424361RPL10chrX

153626883

+GNB2chr7

100274974

+
intron-3CDSENST00000406022ENST00000436220RPL10chrX

153626883

+GNB2chr7

100274974

+
intron-5UTRENST00000406022ENST00000419828RPL10chrX

153626883

+GNB2chr7

100274974

+
intron-intronENST00000406022ENST00000393924RPL10chrX

153626883

+GNB2chr7

100274974

+
intron-intronENST00000406022ENST00000393926RPL10chrX

153626883

+GNB2chr7

100274974

+
intron-intronENST00000406022ENST00000427895RPL10chrX

153626883

+GNB2chr7

100274974

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000369817RPL10chrX153626883+ENST00000303210GNB2chr7100274974+17925994411418325
ENST00000369817RPL10chrX153626883+ENST00000436220GNB2chr7100274974+17665994411418325
ENST00000369817RPL10chrX153626883+ENST00000424361GNB2chr7100274974+17565994411418325
ENST00000424325RPL10chrX153626883+ENST00000303210GNB2chr7100274974+1404211531030325
ENST00000424325RPL10chrX153626883+ENST00000436220GNB2chr7100274974+1378211531030325
ENST00000424325RPL10chrX153626883+ENST00000424361GNB2chr7100274974+1368211531030325

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369817ENST00000303210RPL10chrX153626883+GNB2chr7100274974+0.0048720020.99512804
ENST00000369817ENST00000436220RPL10chrX153626883+GNB2chr7100274974+0.0047188840.99528104
ENST00000369817ENST00000424361RPL10chrX153626883+GNB2chr7100274974+0.0048546430.9951454
ENST00000424325ENST00000303210RPL10chrX153626883+GNB2chr7100274974+0.0057703490.9942297
ENST00000424325ENST00000436220RPL10chrX153626883+GNB2chr7100274974+0.0056374640.9943625
ENST00000424325ENST00000424361RPL10chrX153626883+GNB2chr7100274974+0.0059599480.99404013

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Fusion Genomic Features for RPL10-GNB2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RPL10chrX153626883+GNB2chr7100274974+2.21E-060.99999774
RPL10chrX153626883+GNB2chr7100274974+2.21E-060.99999774

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RPL10-GNB2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:153626883/chr7:100274974)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GNB2

P62879

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGNB2chrX:153626883chr7:100274974ENST00000303210310141_17067341.0RepeatNote=WD 3
TgeneGNB2chrX:153626883chr7:100274974ENST00000303210310182_21267341.0RepeatNote=WD 4
TgeneGNB2chrX:153626883chr7:100274974ENST00000303210310224_25467341.0RepeatNote=WD 5
TgeneGNB2chrX:153626883chr7:100274974ENST00000303210310268_29867341.0RepeatNote=WD 6
TgeneGNB2chrX:153626883chr7:100274974ENST00000303210310310_34067341.0RepeatNote=WD 7
TgeneGNB2chrX:153626883chr7:100274974ENST0000030321031095_12567341.0RepeatNote=WD 2
TgeneGNB2chrX:153626883chr7:100274974ENST0000039392429141_17067341.0RepeatNote=WD 3
TgeneGNB2chrX:153626883chr7:100274974ENST0000039392429182_21267341.0RepeatNote=WD 4
TgeneGNB2chrX:153626883chr7:100274974ENST0000039392429224_25467341.0RepeatNote=WD 5
TgeneGNB2chrX:153626883chr7:100274974ENST0000039392429268_29867341.0RepeatNote=WD 6
TgeneGNB2chrX:153626883chr7:100274974ENST0000039392429310_34067341.0RepeatNote=WD 7
TgeneGNB2chrX:153626883chr7:100274974ENST000003939242995_12567341.0RepeatNote=WD 2
TgeneGNB2chrX:153626883chr7:100274974ENST00000393926310141_17067341.0RepeatNote=WD 3
TgeneGNB2chrX:153626883chr7:100274974ENST00000393926310182_21267341.0RepeatNote=WD 4
TgeneGNB2chrX:153626883chr7:100274974ENST00000393926310224_25467341.0RepeatNote=WD 5
TgeneGNB2chrX:153626883chr7:100274974ENST00000393926310268_29867341.0RepeatNote=WD 6
TgeneGNB2chrX:153626883chr7:100274974ENST00000393926310310_34067341.0RepeatNote=WD 7
TgeneGNB2chrX:153626883chr7:100274974ENST0000039392631095_12567341.0RepeatNote=WD 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGNB2chrX:153626883chr7:100274974ENST0000030321031053_8367341.0RepeatNote=WD 1
TgeneGNB2chrX:153626883chr7:100274974ENST000003939242953_8367341.0RepeatNote=WD 1
TgeneGNB2chrX:153626883chr7:100274974ENST0000039392631053_8367341.0RepeatNote=WD 1


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Fusion Gene Sequence for RPL10-GNB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>75768_75768_1_RPL10-GNB2_RPL10_chrX_153626883_ENST00000369817_GNB2_chr7_100274974_ENST00000303210_length(transcript)=1792nt_BP=599nt
GCAATTCCTGACTTGTACTGCCCCAGTGGTGTTACAGCCTCGAACCCAGTTTCCAGACCTAAGTCACCGCCGGCATCCAGAGTCCCATGA
TGGAAAGGGAGGCTAGGTTCCCCTGGGAAGGACCTTGCACCACTGCTGCAAGTGCACCCCAGAAATCGTCCCAAGCTTTTCTCAAAGGGA
CCTGCAGCCATTTATAAAAGCGACATATCATCCTGGAAAACAGAAATATACGTCTGTCACAGTTAACGGCAAAGCCTAGGGCAAGAGTTC
TACGCCCAAGATGGCCAGCCGGAAGCGGGCTTCTCGCGACCATGTGGCGAAGCCCCATTCGTCAGCTGGCCGCCCGCGGCCCTGGTACCC
GGTCACCTCTCTGATCTGCGCATGTGCTGGGCTACGCCCGGGCGCAAGCGCCAAGAGCGGCTGCGTCTATGGTCATGACGTCTGACAGAG
CGTCCACCCGTCTTCGACAGGACTCTATGGTTCTTACGCGCGCAGACAGACCGCCTATATAAGCCATGCGCAGGCGGAGGAGCGCCTCTT
TCCCTTCGGTGTGCCACTGAAGATCCTGGTGTCGCCATGGGCCGCCGCCCCGCCCGTTGGCTGCTGGTCAGCGCCTCCCAGGATGGGAAG
CTCATCATCTGGGACAGCTACACCACCAACAAGGTCCACGCCATCCCGCTGCGCTCCTCCTGGGTAATGACCTGTGCCTACGCGCCCTCA
GGGAACTTTGTGGCCTGTGGGGGGTTGGACAACATCTGCTCCATCTACAGCCTCAAGACCCGCGAGGGCAACGTCAGGGTCAGCCGGGAG
CTGCCTGGCCACACTGGGTACCTGTCGTGTTGCCGCTTCCTGGATGACAACCAAATCATCACCAGCTCTGGGGATACCACCTGTGCCCTG
TGGGACATTGAGACAGGCCAGCAGACAGTGGGTTTTGCTGGACACAGTGGGGATGTGATGTCCCTGTCCCTGGCCCCCGATGGCCGCACG
TTTGTGTCAGGCGCCTGTGATGCCTCTATCAAGCTGTGGGACGTGCGGGATTCCATGTGCCGACAGACCTTCATCGGCCATGAATCCGAC
ATCAATGCAGTGGCTTTCTTCCCCAACGGCTACGCCTTCACCACCGGCTCTGACGACGCCACGTGCCGCCTCTTCGACCTGCGGGCCGAT
CAGGAGCTCCTCATGTACTCCCATGACAACATCATCTGTGGCATCACCTCTGTTGCCTTCTCGCGCAGCGGACGGCTGCTGCTCGCTGGC
TACGACGACTTCAACTGCAACATCTGGGATGCCATGAAGGGCGACCGTGCAGGAGTCCTCGCTGGCCACGACAACCGCGTGAGCTGCCTC
GGGGTCACCGACGATGGCATGGCTGTGGCCACGGGCTCCTGGGACTCCTTCCTCAAGATCTGGAACTAATGGCCCCACCCCCACTGGGCC
CAGGCCAGGAGGGGCCCTGCCCATGCCCACACTACAGGCCAGGGCTGCGGGGCTGGCGCAATCCCAGCCCCCTTCCCCGGGCCACGGGGC
CTTGGGTCCCTGCCCTCCCACCCAGGTTTGGTTCCTCCCGGGGCCCCCACTGTGGAGATAAGAAGGGGATGGAATGGGGGAAGAGGAGGA
GCAGGAGGCCCTCATCCTTCTGCTGCCCTGGGGTTGGGGCCTCACCCCTCTGGAGGGCCGGAGGCAGGAGGTGGAAACCCCAGGGGCTGG

>75768_75768_1_RPL10-GNB2_RPL10_chrX_153626883_ENST00000369817_GNB2_chr7_100274974_ENST00000303210_length(amino acids)=325AA_BP=53
MTERPPVFDRTLWFLRAQTDRLYKPCAGGGAPLSLRCATEDPGVAMGRRPARWLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY
APSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPD
GRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLL

--------------------------------------------------------------
>75768_75768_2_RPL10-GNB2_RPL10_chrX_153626883_ENST00000369817_GNB2_chr7_100274974_ENST00000424361_length(transcript)=1756nt_BP=599nt
GCAATTCCTGACTTGTACTGCCCCAGTGGTGTTACAGCCTCGAACCCAGTTTCCAGACCTAAGTCACCGCCGGCATCCAGAGTCCCATGA
TGGAAAGGGAGGCTAGGTTCCCCTGGGAAGGACCTTGCACCACTGCTGCAAGTGCACCCCAGAAATCGTCCCAAGCTTTTCTCAAAGGGA
CCTGCAGCCATTTATAAAAGCGACATATCATCCTGGAAAACAGAAATATACGTCTGTCACAGTTAACGGCAAAGCCTAGGGCAAGAGTTC
TACGCCCAAGATGGCCAGCCGGAAGCGGGCTTCTCGCGACCATGTGGCGAAGCCCCATTCGTCAGCTGGCCGCCCGCGGCCCTGGTACCC
GGTCACCTCTCTGATCTGCGCATGTGCTGGGCTACGCCCGGGCGCAAGCGCCAAGAGCGGCTGCGTCTATGGTCATGACGTCTGACAGAG
CGTCCACCCGTCTTCGACAGGACTCTATGGTTCTTACGCGCGCAGACAGACCGCCTATATAAGCCATGCGCAGGCGGAGGAGCGCCTCTT
TCCCTTCGGTGTGCCACTGAAGATCCTGGTGTCGCCATGGGCCGCCGCCCCGCCCGTTGGCTGCTGGTCAGCGCCTCCCAGGATGGGAAG
CTCATCATCTGGGACAGCTACACCACCAACAAGGTCCACGCCATCCCGCTGCGCTCCTCCTGGGTAATGACCTGTGCCTACGCGCCCTCA
GGGAACTTTGTGGCCTGTGGGGGGTTGGACAACATCTGCTCCATCTACAGCCTCAAGACCCGCGAGGGCAACGTCAGGGTCAGCCGGGAG
CTGCCTGGCCACACTGGGTACCTGTCGTGTTGCCGCTTCCTGGATGACAACCAAATCATCACCAGCTCTGGGGATACCACCTGTGCCCTG
TGGGACATTGAGACAGGCCAGCAGACAGTGGGTTTTGCTGGACACAGTGGGGATGTGATGTCCCTGTCCCTGGCCCCCGATGGCCGCACG
TTTGTGTCAGGCGCCTGTGATGCCTCTATCAAGCTGTGGGACGTGCGGGATTCCATGTGCCGACAGACCTTCATCGGCCATGAATCCGAC
ATCAATGCAGTGGCTTTCTTCCCCAACGGCTACGCCTTCACCACCGGCTCTGACGACGCCACGTGCCGCCTCTTCGACCTGCGGGCCGAT
CAGGAGCTCCTCATGTACTCCCATGACAACATCATCTGTGGCATCACCTCTGTTGCCTTCTCGCGCAGCGGACGGCTGCTGCTCGCTGGC
TACGACGACTTCAACTGCAACATCTGGGATGCCATGAAGGGCGACCGTGCAGGAGTCCTCGCTGGCCACGACAACCGCGTGAGCTGCCTC
GGGGTCACCGACGATGGCATGGCTGTGGCCACGGGCTCCTGGGACTCCTTCCTCAAGATCTGGAACTAATGGCCCCACCCCCACTGGGCC
CAGGCCAGGAGGGGCCCTGCCCATGCCCACACTACAGGCCAGGGCTGCGGGGCTGGCGCAATCCCAGCCCCCTTCCCCGGGCCACGGGGC
CTTGGGTCCCTGCCCTCCCACCCAGGTTTGGTTCCTCCCGGGGCCCCCACTGTGGAGATAAGAAGGGGATGGAATGGGGGAAGAGGAGGA
GCAGGAGGCCCTCATCCTTCTGCTGCCCTGGGGTTGGGGCCTCACCCCTCTGGAGGGCCGGAGGCAGGAGGTGGAAACCCCAGGGGCTGG

>75768_75768_2_RPL10-GNB2_RPL10_chrX_153626883_ENST00000369817_GNB2_chr7_100274974_ENST00000424361_length(amino acids)=325AA_BP=53
MTERPPVFDRTLWFLRAQTDRLYKPCAGGGAPLSLRCATEDPGVAMGRRPARWLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY
APSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPD
GRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLL

--------------------------------------------------------------
>75768_75768_3_RPL10-GNB2_RPL10_chrX_153626883_ENST00000369817_GNB2_chr7_100274974_ENST00000436220_length(transcript)=1766nt_BP=599nt
GCAATTCCTGACTTGTACTGCCCCAGTGGTGTTACAGCCTCGAACCCAGTTTCCAGACCTAAGTCACCGCCGGCATCCAGAGTCCCATGA
TGGAAAGGGAGGCTAGGTTCCCCTGGGAAGGACCTTGCACCACTGCTGCAAGTGCACCCCAGAAATCGTCCCAAGCTTTTCTCAAAGGGA
CCTGCAGCCATTTATAAAAGCGACATATCATCCTGGAAAACAGAAATATACGTCTGTCACAGTTAACGGCAAAGCCTAGGGCAAGAGTTC
TACGCCCAAGATGGCCAGCCGGAAGCGGGCTTCTCGCGACCATGTGGCGAAGCCCCATTCGTCAGCTGGCCGCCCGCGGCCCTGGTACCC
GGTCACCTCTCTGATCTGCGCATGTGCTGGGCTACGCCCGGGCGCAAGCGCCAAGAGCGGCTGCGTCTATGGTCATGACGTCTGACAGAG
CGTCCACCCGTCTTCGACAGGACTCTATGGTTCTTACGCGCGCAGACAGACCGCCTATATAAGCCATGCGCAGGCGGAGGAGCGCCTCTT
TCCCTTCGGTGTGCCACTGAAGATCCTGGTGTCGCCATGGGCCGCCGCCCCGCCCGTTGGCTGCTGGTCAGCGCCTCCCAGGATGGGAAG
CTCATCATCTGGGACAGCTACACCACCAACAAGGTCCACGCCATCCCGCTGCGCTCCTCCTGGGTAATGACCTGTGCCTACGCGCCCTCA
GGGAACTTTGTGGCCTGTGGGGGGTTGGACAACATCTGCTCCATCTACAGCCTCAAGACCCGCGAGGGCAACGTCAGGGTCAGCCGGGAG
CTGCCTGGCCACACTGGGTACCTGTCGTGTTGCCGCTTCCTGGATGACAACCAAATCATCACCAGCTCTGGGGATACCACCTGTGCCCTG
TGGGACATTGAGACAGGCCAGCAGACAGTGGGTTTTGCTGGACACAGTGGGGATGTGATGTCCCTGTCCCTGGCCCCCGATGGCCGCACG
TTTGTGTCAGGCGCCTGTGATGCCTCTATCAAGCTGTGGGACGTGCGGGATTCCATGTGCCGACAGACCTTCATCGGCCATGAATCCGAC
ATCAATGCAGTGGCTTTCTTCCCCAACGGCTACGCCTTCACCACCGGCTCTGACGACGCCACGTGCCGCCTCTTCGACCTGCGGGCCGAT
CAGGAGCTCCTCATGTACTCCCATGACAACATCATCTGTGGCATCACCTCTGTTGCCTTCTCGCGCAGCGGACGGCTGCTGCTCGCTGGC
TACGACGACTTCAACTGCAACATCTGGGATGCCATGAAGGGCGACCGTGCAGGAGTCCTCGCTGGCCACGACAACCGCGTGAGCTGCCTC
GGGGTCACCGACGATGGCATGGCTGTGGCCACGGGCTCCTGGGACTCCTTCCTCAAGATCTGGAACTAATGGCCCCACCCCCACTGGGCC
CAGGCCAGGAGGGGCCCTGCCCATGCCCACACTACAGGCCAGGGCTGCGGGGCTGGCGCAATCCCAGCCCCCTTCCCCGGGCCACGGGGC
CTTGGGTCCCTGCCCTCCCACCCAGGTTTGGTTCCTCCCGGGGCCCCCACTGTGGAGATAAGAAGGGGATGGAATGGGGGAAGAGGAGGA
GCAGGAGGCCCTCATCCTTCTGCTGCCCTGGGGTTGGGGCCTCACCCCTCTGGAGGGCCGGAGGCAGGAGGTGGAAACCCCAGGGGCTGG

>75768_75768_3_RPL10-GNB2_RPL10_chrX_153626883_ENST00000369817_GNB2_chr7_100274974_ENST00000436220_length(amino acids)=325AA_BP=53
MTERPPVFDRTLWFLRAQTDRLYKPCAGGGAPLSLRCATEDPGVAMGRRPARWLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY
APSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPD
GRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLL

--------------------------------------------------------------
>75768_75768_4_RPL10-GNB2_RPL10_chrX_153626883_ENST00000424325_GNB2_chr7_100274974_ENST00000303210_length(transcript)=1404nt_BP=211nt
GGGCTACGCCCGGGCGCAAGCGCCAAGAGCGGCTGCGTCTATGGTCATGACGTCTGACAGAGCGTCCACCCGTCTTCGACAGGACTCTAT
GGTTCTTACGCGCGCAGACAGACCGCCTATATAAGCCATGCGCAGGCGGAGGAGCGCCTCTTTCCCTTCGGTGTGCCACTGAAGATCCTG
GTGTCGCCATGGGCCGCCGCCCCGCCCGTTGGCTGCTGGTCAGCGCCTCCCAGGATGGGAAGCTCATCATCTGGGACAGCTACACCACCA
ACAAGGTCCACGCCATCCCGCTGCGCTCCTCCTGGGTAATGACCTGTGCCTACGCGCCCTCAGGGAACTTTGTGGCCTGTGGGGGGTTGG
ACAACATCTGCTCCATCTACAGCCTCAAGACCCGCGAGGGCAACGTCAGGGTCAGCCGGGAGCTGCCTGGCCACACTGGGTACCTGTCGT
GTTGCCGCTTCCTGGATGACAACCAAATCATCACCAGCTCTGGGGATACCACCTGTGCCCTGTGGGACATTGAGACAGGCCAGCAGACAG
TGGGTTTTGCTGGACACAGTGGGGATGTGATGTCCCTGTCCCTGGCCCCCGATGGCCGCACGTTTGTGTCAGGCGCCTGTGATGCCTCTA
TCAAGCTGTGGGACGTGCGGGATTCCATGTGCCGACAGACCTTCATCGGCCATGAATCCGACATCAATGCAGTGGCTTTCTTCCCCAACG
GCTACGCCTTCACCACCGGCTCTGACGACGCCACGTGCCGCCTCTTCGACCTGCGGGCCGATCAGGAGCTCCTCATGTACTCCCATGACA
ACATCATCTGTGGCATCACCTCTGTTGCCTTCTCGCGCAGCGGACGGCTGCTGCTCGCTGGCTACGACGACTTCAACTGCAACATCTGGG
ATGCCATGAAGGGCGACCGTGCAGGAGTCCTCGCTGGCCACGACAACCGCGTGAGCTGCCTCGGGGTCACCGACGATGGCATGGCTGTGG
CCACGGGCTCCTGGGACTCCTTCCTCAAGATCTGGAACTAATGGCCCCACCCCCACTGGGCCCAGGCCAGGAGGGGCCCTGCCCATGCCC
ACACTACAGGCCAGGGCTGCGGGGCTGGCGCAATCCCAGCCCCCTTCCCCGGGCCACGGGGCCTTGGGTCCCTGCCCTCCCACCCAGGTT
TGGTTCCTCCCGGGGCCCCCACTGTGGAGATAAGAAGGGGATGGAATGGGGGAAGAGGAGGAGCAGGAGGCCCTCATCCTTCTGCTGCCC
TGGGGTTGGGGCCTCACCCCTCTGGAGGGCCGGAGGCAGGAGGTGGAAACCCCAGGGGCTGGCTTTTTTAAAACTGGTTTTATTTTAATT

>75768_75768_4_RPL10-GNB2_RPL10_chrX_153626883_ENST00000424325_GNB2_chr7_100274974_ENST00000303210_length(amino acids)=325AA_BP=53
MTERPPVFDRTLWFLRAQTDRLYKPCAGGGAPLSLRCATEDPGVAMGRRPARWLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY
APSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPD
GRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLL

--------------------------------------------------------------
>75768_75768_5_RPL10-GNB2_RPL10_chrX_153626883_ENST00000424325_GNB2_chr7_100274974_ENST00000424361_length(transcript)=1368nt_BP=211nt
GGGCTACGCCCGGGCGCAAGCGCCAAGAGCGGCTGCGTCTATGGTCATGACGTCTGACAGAGCGTCCACCCGTCTTCGACAGGACTCTAT
GGTTCTTACGCGCGCAGACAGACCGCCTATATAAGCCATGCGCAGGCGGAGGAGCGCCTCTTTCCCTTCGGTGTGCCACTGAAGATCCTG
GTGTCGCCATGGGCCGCCGCCCCGCCCGTTGGCTGCTGGTCAGCGCCTCCCAGGATGGGAAGCTCATCATCTGGGACAGCTACACCACCA
ACAAGGTCCACGCCATCCCGCTGCGCTCCTCCTGGGTAATGACCTGTGCCTACGCGCCCTCAGGGAACTTTGTGGCCTGTGGGGGGTTGG
ACAACATCTGCTCCATCTACAGCCTCAAGACCCGCGAGGGCAACGTCAGGGTCAGCCGGGAGCTGCCTGGCCACACTGGGTACCTGTCGT
GTTGCCGCTTCCTGGATGACAACCAAATCATCACCAGCTCTGGGGATACCACCTGTGCCCTGTGGGACATTGAGACAGGCCAGCAGACAG
TGGGTTTTGCTGGACACAGTGGGGATGTGATGTCCCTGTCCCTGGCCCCCGATGGCCGCACGTTTGTGTCAGGCGCCTGTGATGCCTCTA
TCAAGCTGTGGGACGTGCGGGATTCCATGTGCCGACAGACCTTCATCGGCCATGAATCCGACATCAATGCAGTGGCTTTCTTCCCCAACG
GCTACGCCTTCACCACCGGCTCTGACGACGCCACGTGCCGCCTCTTCGACCTGCGGGCCGATCAGGAGCTCCTCATGTACTCCCATGACA
ACATCATCTGTGGCATCACCTCTGTTGCCTTCTCGCGCAGCGGACGGCTGCTGCTCGCTGGCTACGACGACTTCAACTGCAACATCTGGG
ATGCCATGAAGGGCGACCGTGCAGGAGTCCTCGCTGGCCACGACAACCGCGTGAGCTGCCTCGGGGTCACCGACGATGGCATGGCTGTGG
CCACGGGCTCCTGGGACTCCTTCCTCAAGATCTGGAACTAATGGCCCCACCCCCACTGGGCCCAGGCCAGGAGGGGCCCTGCCCATGCCC
ACACTACAGGCCAGGGCTGCGGGGCTGGCGCAATCCCAGCCCCCTTCCCCGGGCCACGGGGCCTTGGGTCCCTGCCCTCCCACCCAGGTT
TGGTTCCTCCCGGGGCCCCCACTGTGGAGATAAGAAGGGGATGGAATGGGGGAAGAGGAGGAGCAGGAGGCCCTCATCCTTCTGCTGCCC
TGGGGTTGGGGCCTCACCCCTCTGGAGGGCCGGAGGCAGGAGGTGGAAACCCCAGGGGCTGGCTTTTTTAAAACTGGTTTTATTTTAATT

>75768_75768_5_RPL10-GNB2_RPL10_chrX_153626883_ENST00000424325_GNB2_chr7_100274974_ENST00000424361_length(amino acids)=325AA_BP=53
MTERPPVFDRTLWFLRAQTDRLYKPCAGGGAPLSLRCATEDPGVAMGRRPARWLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY
APSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPD
GRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLL

--------------------------------------------------------------
>75768_75768_6_RPL10-GNB2_RPL10_chrX_153626883_ENST00000424325_GNB2_chr7_100274974_ENST00000436220_length(transcript)=1378nt_BP=211nt
GGGCTACGCCCGGGCGCAAGCGCCAAGAGCGGCTGCGTCTATGGTCATGACGTCTGACAGAGCGTCCACCCGTCTTCGACAGGACTCTAT
GGTTCTTACGCGCGCAGACAGACCGCCTATATAAGCCATGCGCAGGCGGAGGAGCGCCTCTTTCCCTTCGGTGTGCCACTGAAGATCCTG
GTGTCGCCATGGGCCGCCGCCCCGCCCGTTGGCTGCTGGTCAGCGCCTCCCAGGATGGGAAGCTCATCATCTGGGACAGCTACACCACCA
ACAAGGTCCACGCCATCCCGCTGCGCTCCTCCTGGGTAATGACCTGTGCCTACGCGCCCTCAGGGAACTTTGTGGCCTGTGGGGGGTTGG
ACAACATCTGCTCCATCTACAGCCTCAAGACCCGCGAGGGCAACGTCAGGGTCAGCCGGGAGCTGCCTGGCCACACTGGGTACCTGTCGT
GTTGCCGCTTCCTGGATGACAACCAAATCATCACCAGCTCTGGGGATACCACCTGTGCCCTGTGGGACATTGAGACAGGCCAGCAGACAG
TGGGTTTTGCTGGACACAGTGGGGATGTGATGTCCCTGTCCCTGGCCCCCGATGGCCGCACGTTTGTGTCAGGCGCCTGTGATGCCTCTA
TCAAGCTGTGGGACGTGCGGGATTCCATGTGCCGACAGACCTTCATCGGCCATGAATCCGACATCAATGCAGTGGCTTTCTTCCCCAACG
GCTACGCCTTCACCACCGGCTCTGACGACGCCACGTGCCGCCTCTTCGACCTGCGGGCCGATCAGGAGCTCCTCATGTACTCCCATGACA
ACATCATCTGTGGCATCACCTCTGTTGCCTTCTCGCGCAGCGGACGGCTGCTGCTCGCTGGCTACGACGACTTCAACTGCAACATCTGGG
ATGCCATGAAGGGCGACCGTGCAGGAGTCCTCGCTGGCCACGACAACCGCGTGAGCTGCCTCGGGGTCACCGACGATGGCATGGCTGTGG
CCACGGGCTCCTGGGACTCCTTCCTCAAGATCTGGAACTAATGGCCCCACCCCCACTGGGCCCAGGCCAGGAGGGGCCCTGCCCATGCCC
ACACTACAGGCCAGGGCTGCGGGGCTGGCGCAATCCCAGCCCCCTTCCCCGGGCCACGGGGCCTTGGGTCCCTGCCCTCCCACCCAGGTT
TGGTTCCTCCCGGGGCCCCCACTGTGGAGATAAGAAGGGGATGGAATGGGGGAAGAGGAGGAGCAGGAGGCCCTCATCCTTCTGCTGCCC
TGGGGTTGGGGCCTCACCCCTCTGGAGGGCCGGAGGCAGGAGGTGGAAACCCCAGGGGCTGGCTTTTTTAAAACTGGTTTTATTTTAATT

>75768_75768_6_RPL10-GNB2_RPL10_chrX_153626883_ENST00000424325_GNB2_chr7_100274974_ENST00000436220_length(amino acids)=325AA_BP=53
MTERPPVFDRTLWFLRAQTDRLYKPCAGGGAPLSLRCATEDPGVAMGRRPARWLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY
APSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPD
GRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RPL10-GNB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RPL10-GNB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RPL10-GNB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource