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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATG5-COL19A1 (FusionGDB2 ID:7590)

Fusion Gene Summary for ATG5-COL19A1

check button Fusion gene summary
Fusion gene informationFusion gene name: ATG5-COL19A1
Fusion gene ID: 7590
HgeneTgene
Gene symbol

ATG5

COL19A1

Gene ID

9474

1310

Gene nameautophagy related 5collagen type XIX alpha 1 chain
SynonymsAPG5|APG5-LIKE|APG5L|ASP|SCAR25|hAPG5COL9A1L|D6S228E
Cytomap

6q21

6q13

Type of geneprotein-codingprotein-coding
Descriptionautophagy protein 5APG5 autophagy 5-likeATG5 autophagy related 5 homologapoptosis-specific proteincollagen alpha-1(XIX) chaina1 chain of type XIX collagencollagen XIX, alpha-1 polypeptidecollagen alpha 1 (Y) chaincollagen, type XIX, alpha 1
Modification date2020031320200313
UniProtAcc

Q9H1Y0

Q14993

Ensembl transtripts involved in fusion geneENST00000343245, ENST00000369070, 
ENST00000369076, ENST00000360666, 
ENST00000475645, 		ENST00000393344, 
ENST00000476656, ENST00000322773, 
Fusion gene scores* DoF score25 X 16 X 9=36005 X 5 X 3=75
# samples 295
** MAII scorelog2(29/3600*10)=-3.6338721012021
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATG5 [Title/Abstract] AND COL19A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATG5(106727536)-COL19A1(70608840), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ATG5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across COL19A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A1FE-01AATG5chr6

106727536

-COL19A1chr6

70608840

+


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Fusion Gene ORF analysis for ATG5-COL19A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000343245ENST00000393344ATG5chr6

106727536

-COL19A1chr6

70608840

+
5CDS-intronENST00000343245ENST00000476656ATG5chr6

106727536

-COL19A1chr6

70608840

+
5CDS-intronENST00000369070ENST00000393344ATG5chr6

106727536

-COL19A1chr6

70608840

+
5CDS-intronENST00000369070ENST00000476656ATG5chr6

106727536

-COL19A1chr6

70608840

+
5CDS-intronENST00000369076ENST00000393344ATG5chr6

106727536

-COL19A1chr6

70608840

+
5CDS-intronENST00000369076ENST00000476656ATG5chr6

106727536

-COL19A1chr6

70608840

+
Frame-shiftENST00000369070ENST00000322773ATG5chr6

106727536

-COL19A1chr6

70608840

+
Frame-shiftENST00000369076ENST00000322773ATG5chr6

106727536

-COL19A1chr6

70608840

+
In-frameENST00000343245ENST00000322773ATG5chr6

106727536

-COL19A1chr6

70608840

+
intron-3CDSENST00000360666ENST00000322773ATG5chr6

106727536

-COL19A1chr6

70608840

+
intron-3CDSENST00000475645ENST00000322773ATG5chr6

106727536

-COL19A1chr6

70608840

+
intron-intronENST00000360666ENST00000393344ATG5chr6

106727536

-COL19A1chr6

70608840

+
intron-intronENST00000360666ENST00000476656ATG5chr6

106727536

-COL19A1chr6

70608840

+
intron-intronENST00000475645ENST00000393344ATG5chr6

106727536

-COL19A1chr6

70608840

+
intron-intronENST00000475645ENST00000476656ATG5chr6

106727536

-COL19A1chr6

70608840

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000343245ATG5chr6106727536-ENST00000322773COL19A1chr670608840+671767820040151271

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000343245ENST00000322773ATG5chr6106727536-COL19A1chr670608840+0.000210250.9997898

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Fusion Genomic Features for ATG5-COL19A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATG5chr6106727535-COL19A1chr670608839+1.79E-050.9999821
ATG5chr6106727535-COL19A1chr670608839+1.79E-050.9999821

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ATG5-COL19A1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:106727536/chr6:70608840)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATG5

Q9H1Y0

COL19A1

Q14993

FUNCTION: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. {ECO:0000250|UniProtKB:Q99J83, ECO:0000269|PubMed:12207896, ECO:0000269|PubMed:20580051, ECO:0000269|PubMed:22170153, ECO:0000269|PubMed:26812546}.; FUNCTION: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD. {ECO:0000269|PubMed:15778222, ECO:0000269|PubMed:7796880}.; FUNCTION: (Microbial infection) May act as a proviral factor. In association with ATG12, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection (PubMed:17709747). Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for initiation of HCV replication, but not required once infection is established (PubMed:19666601). {ECO:0000269|PubMed:17709747, ECO:0000269|PubMed:19666601}.FUNCTION: May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle. {ECO:0000269|PubMed:12788917}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCOL19A1chr6:106727536chr6:70608840ENST00000322773151292_349301143.0DomainNote=Collagen-like 1
TgeneCOL19A1chr6:106727536chr6:70608840ENST00000322773151350_391301143.0DomainNote=Collagen-like 2
TgeneCOL19A1chr6:106727536chr6:70608840ENST00000322773151392_433301143.0DomainNote=Collagen-like 3
TgeneCOL19A1chr6:106727536chr6:70608840ENST00000322773151474_516301143.0DomainNote=Collagen-like 4
TgeneCOL19A1chr6:106727536chr6:70608840ENST0000032277315150_234301143.0DomainNote=Laminin G-like
TgeneCOL19A1chr6:106727536chr6:70608840ENST00000322773151568_624301143.0DomainNote=Collagen-like 5
TgeneCOL19A1chr6:106727536chr6:70608840ENST00000322773151626_678301143.0DomainNote=Collagen-like 6
TgeneCOL19A1chr6:106727536chr6:70608840ENST00000322773151728_778301143.0DomainNote=Collagen-like 7
TgeneCOL19A1chr6:106727536chr6:70608840ENST00000322773151779_814301143.0DomainNote=Collagen-like 8
TgeneCOL19A1chr6:106727536chr6:70608840ENST00000322773151845_903301143.0DomainNote=Collagen-like 9
TgeneCOL19A1chr6:106727536chr6:70608840ENST00000322773151904_947301143.0DomainNote=Collagen-like 10
TgeneCOL19A1chr6:106727536chr6:70608840ENST00000322773151948_1004301143.0DomainNote=Collagen-like 11
TgeneCOL19A1chr6:106727536chr6:70608840ENST00000322773151952_954301143.0MotifCell attachment site
TgeneCOL19A1chr6:106727536chr6:70608840ENST000003227731511054_1111301143.0RegionNote=Triple-helical region 6 (COL6)
TgeneCOL19A1chr6:106727536chr6:70608840ENST00000322773151292_351301143.0RegionNote=Triple-helical region 1 (COL1)
TgeneCOL19A1chr6:106727536chr6:70608840ENST00000322773151370_429301143.0RegionNote=Triple-helical region 2 (COL2)
TgeneCOL19A1chr6:106727536chr6:70608840ENST00000322773151448_688301143.0RegionNote=Triple-helical region 3 (COL3)
TgeneCOL19A1chr6:106727536chr6:70608840ENST00000322773151700_818301143.0RegionNote=Triple-helical region 4 (COL4)
TgeneCOL19A1chr6:106727536chr6:70608840ENST00000322773151833_1012301143.0RegionNote=Triple-helical region 5 (COL5)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ATG5-COL19A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7590_7590_1_ATG5-COL19A1_ATG5_chr6_106727536_ENST00000343245_COL19A1_chr6_70608840_ENST00000322773_length(transcript)=6717nt_BP=678nt
GCCCGCCCGGCCGCGATGGCGGGTGAAGGTGGTTCCTCCGGGCAAGGTGGAGTTGGCGAGACGCCGGCCCGGAGCCCTGGGGCCGGTTGG
CGGGTGTGGCCTGCGGGGTCCCTCTTGGGGTACATGTCTGTTGCTTACTAAGTTTGGCTTTGGTTGAAATAAGAATTTAGCCTGTATGTA
CTGCTTTAACTCCTGGAAGAATGACAGATGACAAAGATGTGCTTCGAGATGTGTGGTTTGGACGAATTCCAACTTGTTTCACGCTATATC
AGGATGAGATAACTGAAAGGGAAGCAGAACCATACTATTTGCTTTTGCCAAGAGTAAGTTATTTGACGTTGGTAACTGACAAAGTGAAAA
AGCACTTTCAGAAGGTTATGAGACAAGAAGACATTAGTGAGATATGGTTTGAATATGAAGGCACACCACTGAAATGGCATTATCCAATTG
GTTTGCTATTTGATCTTCTTGCATCAAGTTCAGCTCTTCCTTGGAACATCACAGTACATTTTAAGAGTTTTCCAGAAAAAGACCTTCTGC
ACTGTCCATCTAAGGATGCAATTGAAGCTCATTTTATGTCATGTATGAAAGAAGCTGATGCTTTAAAACATAAAAGTCAAGTAATCAATG
AAATGCAGAAAAAAGATCACAAGCAACTCTGGATGGGATTGCAAAATGAAGAGTCATGCCCTATCCTGAGAATAGAGGGACATCAGCTGA
CATATGACAACATAAACAAACTTGAAGTTTCAGGTTTTGATCTAGGAGACAGCTTTTCTCTAAGACGTGCATTTTGTGAAAGTGATAAAA
CCTGTTTCAAATTGGGAAGTGCACTTCTTATTAGAGACACTATTAAGATATTTCCCAAAGGCCTTCCTGAGGAGTACTCAGTAGCTGCCA
TGTTTCGAGTACGAAGAAACGCCAAAAAGGAACGGTGGTTTCTGTGGCAGGTTTTAAACCAGCAGAATATTCCACAGATTTCTATAGTAG
TTGATGGTGGAAAGAAGGTGGTGGAATTTATGTTTCAAGCCACAGAGGGAGATGTGTTGAACTACATTTTTAGAAATCGAGAACTCCGTC
CTTTGTTTGATCGTCAGTGGCACAAACTTGGCATTAGTATACAATCCCAGGTCATTTCACTTTATATGGATTGTAATTTAATTGCGAGGA
GGCAGACTGATGAAAAGGACACTGTGGATTTCCATGGACGGACAGTTATTGCTACGCGAGCTTCAGATGGCAAGCCTGTGGATATTGAAC
TTCACCAACTTAAAATCTACTGCAGTGCAAACCTCATAGCTCAAGAAACATGTTGTGAAATATCAGATACTAAGTGCCCAGAGCAGGATG
GCTTTGGAAATATTGCATCATCATGGGTAACTGCTCATGCCAGTAAAATGTCTTCATATCTGCCAGCAAAGCAGGAACTTAAAGACCAGT
GCCAGTGCATTCCAAACAAGGGAGAAGCAGGATTACCAGGAGCTCCGGGTTCACCTGGGCAGAAAGGGCATAAAGGAGAGCCGGGTGAAA
ATGGTTTACATGGTGCTCCAGGATTCCCTGGTCAAAAGGGAGAGCAAGGTTTTGAAGGCAGCAAAGGAGAAACTGGTGAAAAGGGTGAAC
AAGGAGAAAAAGGAGATCCAGCTCTGGCTGGCCTTAATGGAGAAAATGGTTTGAAAGGTGACTTGGGTCCTCATGGTCCACCTGGCCCAA
AAGGAGAAAAGGGAGATACAGGACCCCCAGGACCACCAGCCTTACCTGGTTCCCTGGGGATACAAGGCCCCCAAGGTCCACCTGGAAAAG
AGGGTCAGAGGGGAAGACGAGGGAAAACAGGACCTCCCGGAAAACCAGGACCCCCAGGACCACCTGGACCTCCTGGAATACAAGGAATAC
ACCAAACTCTTGGTGGATATTATAACAAGGATAACAAGGGAAATGATGAACATGAAGCTGGAGGCCTGAAAGGAGACAAGGGTGAAACTG
GACTACCAGGATTTCCAGGGTCTGTTGGCCCTAAAGGACAAAAAGGAGAACCTGGAGAGCCTTTTACAAAAGGAGAAAAAGGAGATAGAG
GAGAACCTGGGGTAATAGGATCACAGGGAGTAAAGGGTGAACCTGGAGATCCCGGACCCCCTGGTTTAATAGGAAGCCCAGGACTAAAGG
GTCAGCAAGGATCTGCAGGCTCCATGGGACCCAGAGGACCGCCAGGAGATGTTGGATTGCCAGGAGAACATGGTATCCCAGGAAAACAAG
GCATTAAAGGAGAAAAGGGAGATCCGGGTGGGATCATAGGCCCTCCCGGGCTTCCAGGTCCAAAAGGTGAGGCTGGTCCTCCAGGGAAAA
GCCTGCCAGGGGAACCAGGATTAGATGGAAATCCTGGAGCACCTGGTCCACGTGGGCCAAAGGGTGAAAGAGGACTTCCAGGTGTTCACG
GTTCCCCAGGGGACATAGGCCCACAAGGGATAGGAATTCCTGGCAGAACAGGCGCCCAAGGACCAGCTGGAGAGCCAGGTATTCAGGGTC
CTCGAGGTCTCCCTGGGTTGCCAGGAACTCCAGGGACTCCAGGGAATGATGGAGTTCCAGGGAGAGATGGAAAGCCAGGCCTGCCAGGCC
CCCCAGGTGACCCGATTGCACTTCCTCTCTTGGGAGACATCGGTGCTTTGCTCAAGAATTTCTGTGGCAACTGCCAAGCCAGTGTCCCAG
GGCTGAAAAGCAACAAAGGAGAAGAAGGAGGTGCTGGTGAGCCTGGAAAGTATGATTCCATGGCCCGGAAGGGTGATATAGGGCCACGGG
GTCCTCCAGGAATCCCAGGAAGAGAGGGACCAAAGGGAAGCAAAGGAGAGCGGGGCTACCCTGGGATACCTGGGGAGAAAGGCGATGAGG
GTCTTCAAGGAATTCCAGGCATTCCAGGTGCTCCAGGCCCGACTGGACCCCCTGGCTTAATGGGAAGAACTGGACATCCTGGTCCCACAG
GAGCAAAAGGTGAAAAGGGCAGCGACGGACCCCCTGGGAAACCCGGACCACCTGGACCACCTGGTATTCCATTTAATGAACGAAACGGCA
TGAGCAGTTTATATAAAATTAAGGGAGGTGTGAATGTTCCCAGTTACCCAGGGCCACCCGGTCCTCCTGGCCCAAAAGGCGATCCTGGCC
CAGTGGGAGAGCCTGGTGCAATGGGGTTGCCAGGATTAGAAGGATTTCCAGGTGTAAAGGGAGATCGAGGCCCAGCAGGTCCCCCAGGAA
TAGCAGGGATGTCGGGAAAACCTGGTGCCCCAGGGCCTCCAGGAGTTCCAGGGGAACCGGGTGAGAGAGGACCTGTTGGAGATATAGGTT
TCCCTGGACCAGAAGGACCCTCAGGAAAGCCAGGAATAAATGGAAAAGATGGAATACCAGGTGCTCAGGGCATCATGGGTAAGCCTGGAG
ACAGAGGCCCCAAAGGAGAACGTGGTGATCAGGGGATTCCAGGAGACAGAGGCTCACAAGGTGAACGGGGAAAACCAGGCCTTACAGGCA
TGAAGGGGGCCATCGGTCCTATGGGTCCACCAGGAAACAAGGGCTCCATGGGATCCCCTGGCCACCAAGGCCCTCCAGGCTCTCCAGGCA
TCCCTGGCATTCCGGCTGATGCAGTTTCATTTGAAGAAATAAAGAAGTATATTAATCAAGAGGTCCTAAGGATTTTTGAAGAGAGGATGG
CTGTATTCCTATCCCAGCTCAAGCTGCCAGCAGCAATGTTGGCTGCCCAAGCTTATGGGAGACCTGGGCCACCAGGGAAGGATGGGTTGC
CTGGGCCACCAGGAGACCCTGGACCCCAAGGCTACAGAGGACAGAAGGGAGAAAGAGGTGAACCTGGAATTGGGCTGCCAGGGAGTCCAG
GTCTTCCTGGGACTTCAGCTCTGGGTTTGCCAGGCTCACCAGGTGCCCCAGGCCCACAGGGCCCCCCAGGACCCAGTGGAAGATGTAACC
CAGAAGATTGCCTCTATCCTGTGTCTCATGCCCATCAGCGCACAGGTGGGAATTGAACACACCTGAAGAAGACTTGGTTCCTGGTAACAT
TTCCTTGCCACTGGAGCTCTCTTAATACCGTCAAACCCTCATCATCTGTGGGTTGCTTTTTTTTTTTTTTTTTTTTTTTGGGAGTAAGCC
AGGCATTAAAAGCAACCGTTTGAATCCTATTCCTATAGCAATTGCAAATCAGCATTTTTTGATTTTTCCCAAATTCATTCCATATGTTTT
GCTTTACAATTGCTATGATTTTTACTCAGAGTTTTATATGAAATATGCAAGTAAATCTTATCGTTAGTTCTTCTTCAAAAGGAAATTGCA
TCTTGTGACTTAGTAGACTGATGATGATATCCATTTTGTAGACTCATCAACATGTGGTTGGCCTTTGATTTCTGAATTTTAAAGTTTCAG
ACTTATCTTTTCCTTGGTGTTTAAATTTACTATCATTGCTAAACATCTCGTCAACTTTTTTGATATAGTGCATTGCTCCTGTTGAATGTT
TTTTGACTACTTTTTATAACTTAAGAATTTTTATACCATCTACATCTATCCTACTTATGCAGAAAAATAGGCAATAAGAACTTCATTTTA
CAATTTAGTTTTCAAAAAAAAAATGCAGGAAACTGTTTTATCAGGGAGCCCAAACACCCAGCATAGCCAACTACTGAAATGATTTTGTTA
ATTCTGTATAATGAGCTCAATTCAAAGCAATCACCACTGGCATGAATAAGTACTGCATGAAAAGGGAGTATCAAATTCCAGTTTTGTATG
AGTTCTGCAAAAAAAGCCTAATATTCTGTGGTCCCCTCACTCAGTCTCTCATTTGGTAAACAGAAAGCTGTTTTCCCTACAAGGTGCTTG
GTGGTGAAGCCACCAAGCTGTCTTTGGTACTCTTAAAGCTTCAGTGGCCTAGCAAGATCTTTGGGCCCTTGTATCCATTATCCTTATGAC
CTCATCACCCTCAGACTTTAAGACAAGAAGCCACCATCAAAACAAAGGATGGGATACGTATAGAATGGACTCACTTGTCCTAGAAGATGA
ATGTGTAGTGTCAGCAAATGCATGTTAAGAAGGTGAAGCCCAAAAGCTCTTAAGGAGAATTGTATTTCTCCAGAAGCTGCAGCAAGAGGT
ACAGCTCAACAAAGGAAAACCACAGGACTGGATATGCAACTAGTGCTCAGACCAAAGAGTTCACACCCACTCTAAAACCATGTCCTCTGA
AAAGAAACAAAAATACAGTGATCATCAAATGCCTAAACAGTCTTTCTGTTGGTTAGCTGTACATTCATTGAGGAACTGTTGATTGGCAGG
CACTGATTCTCTAGAACACTGGGCATGAGGATGTTGCAGAAATCTAGATGGTGGGTCCCACAGATGTGAGAACATGCTGCAAGAGCCTGC
CAGCCACAGCAATCAGGACTCACAGCTCTTCAAGGAGCAGTGCAGATTTCAATTTGGCTAAAACAGGATGATTGCTTTTGTCTGTTTACT
GAAAAATGAGTTTAGAAAGGCTAGCCCACTGACATTGGAAAAAGCTGTGAACAGAGTTGTGTCTGAGGAATGTGCCTAATTTAAGGCAGG
GTTTGTTCCAATGCATCCGTGATTTGAACCGGTTTTCATTATAGATTAATGAACTGCTGGTCAGGTACTGTCTACAATGGCTGTGCATAC
CTATAACATTTTAGGTATTTCATATTGAATTATGCTGTATATTTCAATTCCAAGTTTATTTATTTTCCAAGGTTATTTTATTTATTGTAA
GCATTTTGACATTGATTTTTTTTTTTTCGTTTTCTTTCTTGTGCAATACCTACAATGGTGCTGTGTTTTAAACTTACACAATTGGGACAT
ACGTATGTGTTTTCTTAGTAAAATGGTAATTTATCCCGAAAAAGTGTACATAGATCTAAAATTTGGTGCTATGTGTATATCTTGAGCTTT
TAATTTGTTGAATTTTCTAAACGCTTACAACTTATCTGCCACTCATATTAATTTACTTGAATTTGTCATAAAGCTAAATATTTTATATGT
TTTCAAAGATTATTTTTTCATATTAATAGGTTGTTTATCTTTTTGCCTGTTTGCTAATTTAAAAATATTTATTTTATCATTTTAATGTTT
TCATGGACTTTTTTGCTGATGGTAATCAACTTTTTTTGTTTTTTGGTTTTTGAGTTGTTCTTGTCATAGACATAAAAAGACAATTCATTT
TCTTGTTTTATTAACTCTGTTCATTTTTATTCTACAAAATATGTCATGCATTCTTTCTTATGAATTGTATATTTAGAAATCTTTCTAAAT
ACCATTAAGGCTTGACTGGTTAATTCCTATTTCAAGGATTTGGATTTATTCAGGTAATTTGATGGGATGGGGAAATATAATATTGTGTGA
TGCATATTACAAAGTGGACTTGTCACAATGACACAAACTCATTTTTTGTAACTGGGAAATATGACTAAATTTGACGTAACTAGAGAAACA
AGGCTGTATCCACATGGTACAAGCCTTTCTCACCCTACTCTATTATTTACCTTCAGATACTTTTTCCTGCCTCAGCTCTGTACACATGAT
ATGCAACAAAGGGCAGCAAGAAATGCTGGGTCCACCTAATTTAACACAAAATGAAGTTGAGATTCGGCAGTTGCCCAATTCCTTTAATAA

>7590_7590_1_ATG5-COL19A1_ATG5_chr6_106727536_ENST00000343245_COL19A1_chr6_70608840_ENST00000322773_length(amino acids)=1271AA_BP=159
MTDDKDVLRDVWFGRIPTCFTLYQDEITEREAEPYYLLLPRVSYLTLVTDKVKKHFQKVMRQEDISEIWFEYEGTPLKWHYPIGLLFDLL
ASSSALPWNITVHFKSFPEKDLLHCPSKDAIEAHFMSCMKEADALKHKSQVINEMQKKDHKQLWMGLQNEESCPILRIEGHQLTYDNINK
LEVSGFDLGDSFSLRRAFCESDKTCFKLGSALLIRDTIKIFPKGLPEEYSVAAMFRVRRNAKKERWFLWQVLNQQNIPQISIVVDGGKKV
VEFMFQATEGDVLNYIFRNRELRPLFDRQWHKLGISIQSQVISLYMDCNLIARRQTDEKDTVDFHGRTVIATRASDGKPVDIELHQLKIY
CSANLIAQETCCEISDTKCPEQDGFGNIASSWVTAHASKMSSYLPAKQELKDQCQCIPNKGEAGLPGAPGSPGQKGHKGEPGENGLHGAP
GFPGQKGEQGFEGSKGETGEKGEQGEKGDPALAGLNGENGLKGDLGPHGPPGPKGEKGDTGPPGPPALPGSLGIQGPQGPPGKEGQRGRR
GKTGPPGKPGPPGPPGPPGIQGIHQTLGGYYNKDNKGNDEHEAGGLKGDKGETGLPGFPGSVGPKGQKGEPGEPFTKGEKGDRGEPGVIG
SQGVKGEPGDPGPPGLIGSPGLKGQQGSAGSMGPRGPPGDVGLPGEHGIPGKQGIKGEKGDPGGIIGPPGLPGPKGEAGPPGKSLPGEPG
LDGNPGAPGPRGPKGERGLPGVHGSPGDIGPQGIGIPGRTGAQGPAGEPGIQGPRGLPGLPGTPGTPGNDGVPGRDGKPGLPGPPGDPIA
LPLLGDIGALLKNFCGNCQASVPGLKSNKGEEGGAGEPGKYDSMARKGDIGPRGPPGIPGREGPKGSKGERGYPGIPGEKGDEGLQGIPG
IPGAPGPTGPPGLMGRTGHPGPTGAKGEKGSDGPPGKPGPPGPPGIPFNERNGMSSLYKIKGGVNVPSYPGPPGPPGPKGDPGPVGEPGA
MGLPGLEGFPGVKGDRGPAGPPGIAGMSGKPGAPGPPGVPGEPGERGPVGDIGFPGPEGPSGKPGINGKDGIPGAQGIMGKPGDRGPKGE
RGDQGIPGDRGSQGERGKPGLTGMKGAIGPMGPPGNKGSMGSPGHQGPPGSPGIPGIPADAVSFEEIKKYINQEVLRIFEERMAVFLSQL
KLPAAMLAAQAYGRPGPPGKDGLPGPPGDPGPQGYRGQKGERGEPGIGLPGSPGLPGTSALGLPGSPGAPGPQGPPGPSGRCNPEDCLYP

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Fusion Gene PPI Analysis for ATG5-COL19A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATG5-COL19A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATG5-COL19A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource