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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RPL14-SRP14 (FusionGDB2 ID:75961)

Fusion Gene Summary for RPL14-SRP14

check button Fusion gene summary
Fusion gene informationFusion gene name: RPL14-SRP14
Fusion gene ID: 75961
HgeneTgene
Gene symbol

RPL14

SRP14

Gene ID

9045

6727

Gene nameribosomal protein L14signal recognition particle 14
SynonymsCAG-ISL-7|CTG-B33|L14|RL14|hRL14ALURBP
Cytomap

3p22.1

15q15.1

Type of geneprotein-codingprotein-coding
Description60S ribosomal protein L14large ribosomal subunit protein eL14signal recognition particle 14 kDa protein18 kDa Alu RNA-binding proteinhomologous Alu RNA binding protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000416518, ENST00000338970, 
ENST00000396203, ENST00000461368, 
ENST00000267884, ENST00000558527, 
ENST00000558720, ENST00000560773, 
ENST00000559081, 
Fusion gene scores* DoF score13 X 16 X 5=10406 X 7 X 5=210
# samples 168
** MAII scorelog2(16/1040*10)=-2.70043971814109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPL14 [Title/Abstract] AND SRP14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRPL14(40503505)-SRP14(40328595), # samples:1
RPL14(40503471)-SRP14(40328611), # samples:1
Anticipated loss of major functional domain due to fusion event.RPL14-SRP14 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
RPL14-SRP14 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
RPL14-SRP14 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
RPL14-SRP14 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSRP14

GO:0042493

response to drug

18089836


check buttonFusion gene breakpoints across RPL14 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SRP14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-7723-01ARPL14chr3

40503505

+SRP14chr15

40328595

-
ChimerDB4UCECTCGA-E6-A1M0-01ARPL14chr3

40503471

+SRP14chr15

40328611

-


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Fusion Gene ORF analysis for RPL14-SRP14

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000416518ENST00000267884RPL14chr3

40503505

+SRP14chr15

40328595

-
3UTR-3CDSENST00000416518ENST00000267884RPL14chr3

40503471

+SRP14chr15

40328611

-
3UTR-5UTRENST00000416518ENST00000558527RPL14chr3

40503505

+SRP14chr15

40328595

-
3UTR-5UTRENST00000416518ENST00000558527RPL14chr3

40503471

+SRP14chr15

40328611

-
3UTR-5UTRENST00000416518ENST00000558720RPL14chr3

40503505

+SRP14chr15

40328595

-
3UTR-5UTRENST00000416518ENST00000558720RPL14chr3

40503471

+SRP14chr15

40328611

-
3UTR-5UTRENST00000416518ENST00000560773RPL14chr3

40503505

+SRP14chr15

40328595

-
3UTR-5UTRENST00000416518ENST00000560773RPL14chr3

40503471

+SRP14chr15

40328611

-
3UTR-intronENST00000416518ENST00000559081RPL14chr3

40503505

+SRP14chr15

40328595

-
3UTR-intronENST00000416518ENST00000559081RPL14chr3

40503471

+SRP14chr15

40328611

-
5CDS-5UTRENST00000338970ENST00000558527RPL14chr3

40503505

+SRP14chr15

40328595

-
5CDS-5UTRENST00000338970ENST00000558527RPL14chr3

40503471

+SRP14chr15

40328611

-
5CDS-5UTRENST00000338970ENST00000558720RPL14chr3

40503505

+SRP14chr15

40328595

-
5CDS-5UTRENST00000338970ENST00000558720RPL14chr3

40503471

+SRP14chr15

40328611

-
5CDS-5UTRENST00000338970ENST00000560773RPL14chr3

40503505

+SRP14chr15

40328595

-
5CDS-5UTRENST00000338970ENST00000560773RPL14chr3

40503471

+SRP14chr15

40328611

-
5CDS-5UTRENST00000396203ENST00000558527RPL14chr3

40503505

+SRP14chr15

40328595

-
5CDS-5UTRENST00000396203ENST00000558527RPL14chr3

40503471

+SRP14chr15

40328611

-
5CDS-5UTRENST00000396203ENST00000558720RPL14chr3

40503505

+SRP14chr15

40328595

-
5CDS-5UTRENST00000396203ENST00000558720RPL14chr3

40503471

+SRP14chr15

40328611

-
5CDS-5UTRENST00000396203ENST00000560773RPL14chr3

40503505

+SRP14chr15

40328595

-
5CDS-5UTRENST00000396203ENST00000560773RPL14chr3

40503471

+SRP14chr15

40328611

-
5CDS-intronENST00000338970ENST00000559081RPL14chr3

40503505

+SRP14chr15

40328595

-
5CDS-intronENST00000338970ENST00000559081RPL14chr3

40503471

+SRP14chr15

40328611

-
5CDS-intronENST00000396203ENST00000559081RPL14chr3

40503505

+SRP14chr15

40328595

-
5CDS-intronENST00000396203ENST00000559081RPL14chr3

40503471

+SRP14chr15

40328611

-
Frame-shiftENST00000396203ENST00000267884RPL14chr3

40503505

+SRP14chr15

40328595

-
Frame-shiftENST00000396203ENST00000267884RPL14chr3

40503471

+SRP14chr15

40328611

-
In-frameENST00000338970ENST00000267884RPL14chr3

40503505

+SRP14chr15

40328595

-
In-frameENST00000338970ENST00000267884RPL14chr3

40503471

+SRP14chr15

40328611

-
intron-3CDSENST00000461368ENST00000267884RPL14chr3

40503505

+SRP14chr15

40328595

-
intron-3CDSENST00000461368ENST00000267884RPL14chr3

40503471

+SRP14chr15

40328611

-
intron-5UTRENST00000461368ENST00000558527RPL14chr3

40503505

+SRP14chr15

40328595

-
intron-5UTRENST00000461368ENST00000558527RPL14chr3

40503471

+SRP14chr15

40328611

-
intron-5UTRENST00000461368ENST00000558720RPL14chr3

40503505

+SRP14chr15

40328595

-
intron-5UTRENST00000461368ENST00000558720RPL14chr3

40503471

+SRP14chr15

40328611

-
intron-5UTRENST00000461368ENST00000560773RPL14chr3

40503505

+SRP14chr15

40328595

-
intron-5UTRENST00000461368ENST00000560773RPL14chr3

40503471

+SRP14chr15

40328611

-
intron-intronENST00000461368ENST00000559081RPL14chr3

40503505

+SRP14chr15

40328595

-
intron-intronENST00000461368ENST00000559081RPL14chr3

40503471

+SRP14chr15

40328611

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000338970RPL14chr340503505+ENST00000267884SRP14chr1540328595-143577930653207
ENST00000338970RPL14chr340503471+ENST00000267884SRP14chr1540328611-14858139170306

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000338970ENST00000267884RPL14chr340503505+SRP14chr1540328595-0.0169684630.9830315
ENST00000338970ENST00000267884RPL14chr340503471+SRP14chr1540328611-0.0022902940.99770975

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Fusion Genomic Features for RPL14-SRP14


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RPL14-SRP14


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:40503505/chr15:40328595)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSRP14chr3:40503471chr15:40328611ENST0000026788405108_1360137.0Compositional biasNote=Ala/Thr-rich
TgeneSRP14chr3:40503505chr15:40328595ENST0000026788405108_1360137.0Compositional biasNote=Ala/Thr-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRPL14chr3:40503471chr15:40328611ENST00000338970+16171_1900216.0RegionNote=4 X 5 AA tandem repeats of Q-K-A-[PAS]-X
HgeneRPL14chr3:40503471chr15:40328611ENST00000338970+16193_1980216.0RegionNote=2 X 3 AA tandem repeats of K-[GA]-Q
HgeneRPL14chr3:40503471chr15:40328611ENST00000396203+16171_1900216.0RegionNote=4 X 5 AA tandem repeats of Q-K-A-[PAS]-X
HgeneRPL14chr3:40503471chr15:40328611ENST00000396203+16193_1980216.0RegionNote=2 X 3 AA tandem repeats of K-[GA]-Q
HgeneRPL14chr3:40503505chr15:40328595ENST00000338970+16171_1900216.0RegionNote=4 X 5 AA tandem repeats of Q-K-A-[PAS]-X
HgeneRPL14chr3:40503505chr15:40328595ENST00000338970+16193_1980216.0RegionNote=2 X 3 AA tandem repeats of K-[GA]-Q
HgeneRPL14chr3:40503505chr15:40328595ENST00000396203+16171_1900216.0RegionNote=4 X 5 AA tandem repeats of Q-K-A-[PAS]-X
HgeneRPL14chr3:40503505chr15:40328595ENST00000396203+16193_1980216.0RegionNote=2 X 3 AA tandem repeats of K-[GA]-Q
HgeneRPL14chr3:40503471chr15:40328611ENST00000338970+16171_1750216.0RepeatNote=1-1
HgeneRPL14chr3:40503471chr15:40328611ENST00000338970+16176_1800216.0RepeatNote=1-2
HgeneRPL14chr3:40503471chr15:40328611ENST00000338970+16181_1850216.0RepeatNote=1-3
HgeneRPL14chr3:40503471chr15:40328611ENST00000338970+16186_1900216.0RepeatNote=1-4
HgeneRPL14chr3:40503471chr15:40328611ENST00000338970+16193_1950216.0RepeatNote=2-1
HgeneRPL14chr3:40503471chr15:40328611ENST00000338970+16196_1980216.0RepeatNote=2-2
HgeneRPL14chr3:40503471chr15:40328611ENST00000396203+16171_1750216.0RepeatNote=1-1
HgeneRPL14chr3:40503471chr15:40328611ENST00000396203+16176_1800216.0RepeatNote=1-2
HgeneRPL14chr3:40503471chr15:40328611ENST00000396203+16181_1850216.0RepeatNote=1-3
HgeneRPL14chr3:40503471chr15:40328611ENST00000396203+16186_1900216.0RepeatNote=1-4
HgeneRPL14chr3:40503471chr15:40328611ENST00000396203+16193_1950216.0RepeatNote=2-1
HgeneRPL14chr3:40503471chr15:40328611ENST00000396203+16196_1980216.0RepeatNote=2-2
HgeneRPL14chr3:40503505chr15:40328595ENST00000338970+16171_1750216.0RepeatNote=1-1
HgeneRPL14chr3:40503505chr15:40328595ENST00000338970+16176_1800216.0RepeatNote=1-2
HgeneRPL14chr3:40503505chr15:40328595ENST00000338970+16181_1850216.0RepeatNote=1-3
HgeneRPL14chr3:40503505chr15:40328595ENST00000338970+16186_1900216.0RepeatNote=1-4
HgeneRPL14chr3:40503505chr15:40328595ENST00000338970+16193_1950216.0RepeatNote=2-1
HgeneRPL14chr3:40503505chr15:40328595ENST00000338970+16196_1980216.0RepeatNote=2-2
HgeneRPL14chr3:40503505chr15:40328595ENST00000396203+16171_1750216.0RepeatNote=1-1
HgeneRPL14chr3:40503505chr15:40328595ENST00000396203+16176_1800216.0RepeatNote=1-2
HgeneRPL14chr3:40503505chr15:40328595ENST00000396203+16181_1850216.0RepeatNote=1-3
HgeneRPL14chr3:40503505chr15:40328595ENST00000396203+16186_1900216.0RepeatNote=1-4
HgeneRPL14chr3:40503505chr15:40328595ENST00000396203+16193_1950216.0RepeatNote=2-1
HgeneRPL14chr3:40503505chr15:40328595ENST00000396203+16196_1980216.0RepeatNote=2-2


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Fusion Gene Sequence for RPL14-SRP14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>75961_75961_1_RPL14-SRP14_RPL14_chr3_40503471_ENST00000338970_SRP14_chr15_40328611_ENST00000267884_length(transcript)=1485nt_BP=813nt
GGCGGTGCGTTCTTCTACACATGCGCAGGGTTGGGCGGGTCTTCTTCCTTCTCGCCTAACGCCGCCAACATGGTGTTCAGGCGCTTCGTG
GAGGTTGGCCGGGTGGCCTATGTCTCCTTTGGACCTCATGCCGGAAAATTGGTCGCGATTGTAGATGTTATTGATCAGAACAGGGCTTTG
GTCGATGGACCTTGCACTCAAGTGAGGAGACAGGCCATGCCTTTCAAGTGCATGCAGCTCACTGATTTCATCCTCAAGTTTCCGCACAGT
GCCCACCAGAAGTATGTCCGACAAGCCTGGCAGAAGGCAGACATCAATACAAAATGGGCAGCCACACGATGGGCCAAGAAGATTGAAGCC
AGAGAAAGGAAAGCCAAGATGACAGATTTTGATCGTTTTAAAGTTATGAAGGCAAAGAAAATGGCAGCTCTCCTGAAAGCTTCTCCCAAA
AAAGCACCTGGTACTAAGGGTACTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTAAAGTTCCAGCAAAAAAGATCACCGCCGCGAGTAAA
AAGGCTCCAGCCCAGAAGGTTCCTGCCCAGAAAGCCACAGGCCAGAAAGCAGCGCCTGCTCCAAAAGCTCAGAAGGGTCAAAAAGCTCCA
GCCCAGAAAGCACCTGCTCCAAAGGCATCTGGCAAGAAAGCATAAGTGGCAATCATAAAAAGTAATAAAGGTTCTTTTTGACCTGTTGAC
AAATGTATTTAAGCCTTTGGATTTAAAGCCTGTTGAGGCTGGAGTTAGGAGGCAGATTGATAGTAGGATTATAATAAACATTAAATAATC
AGTGCAGCAGCAGCAGCACCTGCCGCAGCAGCAACAGCACCAACAACAGCAGCAACAACAGCAGCAACAGCAGCACAGTAAAGGGCATAC
ATTTCCTGCTTTCACCAATTAACCACTGAATTGCTATTTTTTCCTTTTGGCCAGATAGCTAGGTTTCTGGTTCCCCCACAGTAGGTGTTT
TCACATAAGATTAGGGTCCTTTTGGAAAGAATAGTTGCAGTGTTTATAGGATAGTTGTGGTAAGAATCTAGTTTATTTTGCATTTGGCTA
ATTGGTCTGTGCTGCATGGTTATATACTCCTGGATTATAGATTAAAAGTCTCTGTAGACATCTCTGTGAAGAGCAAGCTATCATTAAACA
TGTCTGTTTATCAGCACTGTCTCTTTATTCCTTTCCCAACCCATTTTAATAGTTCTGGCAATAACTACTAAATCTAGAATGATGTGATTA
ATGAATAGGCTTTAGCTCTATAATATCTTCTAGGTTATTAGAATTGAAACCTGACAGTTTTATAAAAAGTCATGTTATCTCATGAGCTGC
TTCCCACCTGGCTGTATAATTTTATCATCATGGTTCCCCAGTTTCGATGAGTTCTCACAGTCAAATGAGAGTTTGTTTAACCACCTTAGG

>75961_75961_1_RPL14-SRP14_RPL14_chr3_40503471_ENST00000338970_SRP14_chr15_40328611_ENST00000267884_length(amino acids)=306AA_BP=1
MVKAGNVCPLLCCCCCCCCCCCWCCCCCGRCCCCCTDYLMFIIILLSICLLTPASTGFKSKGLNTFVNRSKRTFITFYDCHLCFLARCLW
SRCFLGWSFLTLLSFWSRRCFLACGFLGRNLLGWSLFTRGGDLFCWNFSSSSSSSSSSSTLSTRCFFGRSFQESCHFLCLHNFKTIKICH
LGFPFSGFNLLGPSCGCPFCIDVCLLPGLSDILLVGTVRKLEDEISELHALERHGLSPHLSARSIDQSPVLINNIYNRDQFSGMRSKGDI

--------------------------------------------------------------
>75961_75961_2_RPL14-SRP14_RPL14_chr3_40503505_ENST00000338970_SRP14_chr15_40328595_ENST00000267884_length(transcript)=1435nt_BP=779nt
GGCGGTGCGTTCTTCTACACATGCGCAGGGTTGGGCGGGTCTTCTTCCTTCTCGCCTAACGCCGCCAACATGGTGTTCAGGCGCTTCGTG
GAGGTTGGCCGGGTGGCCTATGTCTCCTTTGGACCTCATGCCGGAAAATTGGTCGCGATTGTAGATGTTATTGATCAGAACAGGGCTTTG
GTCGATGGACCTTGCACTCAAGTGAGGAGACAGGCCATGCCTTTCAAGTGCATGCAGCTCACTGATTTCATCCTCAAGTTTCCGCACAGT
GCCCACCAGAAGTATGTCCGACAAGCCTGGCAGAAGGCAGACATCAATACAAAATGGGCAGCCACACGATGGGCCAAGAAGATTGAAGCC
AGAGAAAGGAAAGCCAAGATGACAGATTTTGATCGTTTTAAAGTTATGAAGGCAAAGAAAATGCTGGTACTAAGGGTACTGCTGCTGCTG
CTGCTGCTGCTGCTGCTGCTAAAGTTCCAGCAAAAAAGATCACCGCCGCGAGTAAAAAGGCTCCAGCCCAGAAGGTTCCTGCCCAGAAAG
CCACAGGCCAGAAAGCAGCGCCTGCTCCAAAAGCTCAGAAGGGTCAAAAAGCTCCAGCCCAGAAAGCACCTGCTCCAAAGGCATCTGGCA
AGAAAGCATAAGTGGCAATCATAAAAAGTAATAAAGGTTCTTTTTGACCTGTTGACAAATGTATTTAAGCCTTTGGATTTAAAGCCTGTT
GAGGCTGGAGTTAGGAGGCAGATTGATAGTAGGATTATAATAAACATTAAATAATCAGTCTGCCGCAGCAGCAACAGCACCAACAACAGC
AGCAACAACAGCAGCAACAGCAGCACAGTAAAGGGCATACATTTCCTGCTTTCACCAATTAACCACTGAATTGCTATTTTTTCCTTTTGG
CCAGATAGCTAGGTTTCTGGTTCCCCCACAGTAGGTGTTTTCACATAAGATTAGGGTCCTTTTGGAAAGAATAGTTGCAGTGTTTATAGG
ATAGTTGTGGTAAGAATCTAGTTTATTTTGCATTTGGCTAATTGGTCTGTGCTGCATGGTTATATACTCCTGGATTATAGATTAAAAGTC
TCTGTAGACATCTCTGTGAAGAGCAAGCTATCATTAAACATGTCTGTTTATCAGCACTGTCTCTTTATTCCTTTCCCAACCCATTTTAAT
AGTTCTGGCAATAACTACTAAATCTAGAATGATGTGATTAATGAATAGGCTTTAGCTCTATAATATCTTCTAGGTTATTAGAATTGAAAC
CTGACAGTTTTATAAAAAGTCATGTTATCTCATGAGCTGCTTCCCACCTGGCTGTATAATTTTATCATCATGGTTCCCCAGTTTCGATGA

>75961_75961_2_RPL14-SRP14_RPL14_chr3_40503505_ENST00000338970_SRP14_chr15_40328595_ENST00000267884_length(amino acids)=207AA_BP=
MGGSSSFSPNAANMVFRRFVEVGRVAYVSFGPHAGKLVAIVDVIDQNRALVDGPCTQVRRQAMPFKCMQLTDFILKFPHSAHQKYVRQAW
QKADINTKWAATRWAKKIEARERKAKMTDFDRFKVMKAKKMLVLRVLLLLLLLLLLLKFQQKRSPPRVKRLQPRRFLPRKPQARKQRLLQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RPL14-SRP14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RPL14-SRP14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RPL14-SRP14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource