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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATG5-QRSL1 (FusionGDB2 ID:7600)

Fusion Gene Summary for ATG5-QRSL1

check button Fusion gene summary
Fusion gene informationFusion gene name: ATG5-QRSL1
Fusion gene ID: 7600
HgeneTgene
Gene symbol

ATG5

QRSL1

Gene ID

9474

55278

Gene nameautophagy related 5glutaminyl-tRNA amidotransferase subunit QRSL1
SynonymsAPG5|APG5-LIKE|APG5L|ASP|SCAR25|hAPG5GatA
Cytomap

6q21

6q21

Type of geneprotein-codingprotein-coding
Descriptionautophagy protein 5APG5 autophagy 5-likeATG5 autophagy related 5 homologapoptosis-specific proteinglutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrialQRSL1, glutaminyl-tRNA amidotransferase subunit Aglu-AdT subunit Aglutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1glutaminyl-tRNA synthase-like protein 1glutamyl-tRNA(Gln) amidotransf
Modification date2020031320200313
UniProtAcc

Q9H1Y0

.
Ensembl transtripts involved in fusion geneENST00000343245, ENST00000369070, 
ENST00000369076, ENST00000360666, 
ENST00000475645, 		ENST00000369044, 
ENST00000467262, ENST00000369046, 
Fusion gene scores* DoF score25 X 16 X 9=36009 X 9 X 5=405
# samples 2913
** MAII scorelog2(29/3600*10)=-3.6338721012021
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/405*10)=-1.63941028474353
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATG5 [Title/Abstract] AND QRSL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATG5(106727536)-QRSL1(107113657), # samples:3
QRSL1(107090965)-ATG5(106740981), # samples:1
Anticipated loss of major functional domain due to fusion event.ATG5-QRSL1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneQRSL1

GO:0070681

glutaminyl-tRNAGln biosynthesis via transamidation

19805282


check buttonFusion gene breakpoints across ATG5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across QRSL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AN-A04C-01AATG5chr6

106727536

-QRSL1chr6

107113657

+
ChimerDB4BRCATCGA-AN-A04CATG5chr6

106727535

-QRSL1chr6

107113656

+


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Fusion Gene ORF analysis for ATG5-QRSL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000343245ENST00000369044ATG5chr6

106727536

-QRSL1chr6

107113657

+
5CDS-intronENST00000343245ENST00000369044ATG5chr6

106727535

-QRSL1chr6

107113656

+
5CDS-intronENST00000343245ENST00000467262ATG5chr6

106727536

-QRSL1chr6

107113657

+
5CDS-intronENST00000343245ENST00000467262ATG5chr6

106727535

-QRSL1chr6

107113656

+
5CDS-intronENST00000369070ENST00000369044ATG5chr6

106727536

-QRSL1chr6

107113657

+
5CDS-intronENST00000369070ENST00000369044ATG5chr6

106727535

-QRSL1chr6

107113656

+
5CDS-intronENST00000369070ENST00000467262ATG5chr6

106727536

-QRSL1chr6

107113657

+
5CDS-intronENST00000369070ENST00000467262ATG5chr6

106727535

-QRSL1chr6

107113656

+
5CDS-intronENST00000369076ENST00000369044ATG5chr6

106727536

-QRSL1chr6

107113657

+
5CDS-intronENST00000369076ENST00000369044ATG5chr6

106727535

-QRSL1chr6

107113656

+
5CDS-intronENST00000369076ENST00000467262ATG5chr6

106727536

-QRSL1chr6

107113657

+
5CDS-intronENST00000369076ENST00000467262ATG5chr6

106727535

-QRSL1chr6

107113656

+
Frame-shiftENST00000343245ENST00000369046ATG5chr6

106727536

-QRSL1chr6

107113657

+
Frame-shiftENST00000343245ENST00000369046ATG5chr6

106727535

-QRSL1chr6

107113656

+
In-frameENST00000369070ENST00000369046ATG5chr6

106727536

-QRSL1chr6

107113657

+
In-frameENST00000369070ENST00000369046ATG5chr6

106727535

-QRSL1chr6

107113656

+
In-frameENST00000369076ENST00000369046ATG5chr6

106727536

-QRSL1chr6

107113657

+
In-frameENST00000369076ENST00000369046ATG5chr6

106727535

-QRSL1chr6

107113656

+
intron-3CDSENST00000360666ENST00000369046ATG5chr6

106727536

-QRSL1chr6

107113657

+
intron-3CDSENST00000360666ENST00000369046ATG5chr6

106727535

-QRSL1chr6

107113656

+
intron-3CDSENST00000475645ENST00000369046ATG5chr6

106727536

-QRSL1chr6

107113657

+
intron-3CDSENST00000475645ENST00000369046ATG5chr6

106727535

-QRSL1chr6

107113656

+
intron-intronENST00000360666ENST00000369044ATG5chr6

106727536

-QRSL1chr6

107113657

+
intron-intronENST00000360666ENST00000369044ATG5chr6

106727535

-QRSL1chr6

107113656

+
intron-intronENST00000360666ENST00000467262ATG5chr6

106727536

-QRSL1chr6

107113657

+
intron-intronENST00000360666ENST00000467262ATG5chr6

106727535

-QRSL1chr6

107113656

+
intron-intronENST00000475645ENST00000369044ATG5chr6

106727536

-QRSL1chr6

107113657

+
intron-intronENST00000475645ENST00000369044ATG5chr6

106727535

-QRSL1chr6

107113656

+
intron-intronENST00000475645ENST00000467262ATG5chr6

106727536

-QRSL1chr6

107113657

+
intron-intronENST00000475645ENST00000467262ATG5chr6

106727535

-QRSL1chr6

107113656

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000369070ATG5chr6106727536-ENST00000369046QRSL1chr6107113657+3310674406894162
ENST00000369076ATG5chr6106727536-ENST00000369046QRSL1chr6107113657+34388023241022232
ENST00000369070ATG5chr6106727535-ENST00000369046QRSL1chr6107113656+3310674406894162
ENST00000369076ATG5chr6106727535-ENST00000369046QRSL1chr6107113656+34388023241022232

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369070ENST00000369046ATG5chr6106727536-QRSL1chr6107113657+0.0048439840.99515605
ENST00000369076ENST00000369046ATG5chr6106727536-QRSL1chr6107113657+0.0008891180.9991109
ENST00000369070ENST00000369046ATG5chr6106727535-QRSL1chr6107113656+0.0048439840.99515605
ENST00000369076ENST00000369046ATG5chr6106727535-QRSL1chr6107113656+0.0008891180.9991109

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Fusion Genomic Features for ATG5-QRSL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATG5chr6106727535-QRSL1chr6107113656+8.03E-080.9999999
ATG5chr6106727535-QRSL1chr6107113656+8.03E-080.9999999
ATG5chr6106727535-QRSL1chr6107113656+8.03E-080.9999999
ATG5chr6106727535-QRSL1chr6107113656+8.03E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ATG5-QRSL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:106727536/chr6:107113657)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATG5

Q9H1Y0

.
FUNCTION: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. {ECO:0000250|UniProtKB:Q99J83, ECO:0000269|PubMed:12207896, ECO:0000269|PubMed:20580051, ECO:0000269|PubMed:22170153, ECO:0000269|PubMed:26812546}.; FUNCTION: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD. {ECO:0000269|PubMed:15778222, ECO:0000269|PubMed:7796880}.; FUNCTION: (Microbial infection) May act as a proviral factor. In association with ATG12, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection (PubMed:17709747). Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for initiation of HCV replication, but not required once infection is established (PubMed:19666601). {ECO:0000269|PubMed:17709747, ECO:0000269|PubMed:19666601}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ATG5-QRSL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7600_7600_1_ATG5-QRSL1_ATG5_chr6_106727535_ENST00000369070_QRSL1_chr6_107113656_ENST00000369046_length(transcript)=3310nt_BP=674nt
CTGGACTTGTGGTGCGCTGCCAGGGCTCCGCAGCGTTGCCGGTTGTATTCGCTGGATACCAGAGGGCGGAAGTGCAGCAGGGTTCAGCTC
CGACCTCCGCGCCGGTGCTTTTTGCGGCTGCGCGGGCTTCCTGGAGTCCTGCTACCGCGTCCCCGCAGGACAGTGTGTCAGGCGGGCAGC
TTGCCCCGCCGCCCCACCGGAGCGCGGAATCTGGGCGTCCCCACCAGTGCGGGGAGCCGGAAGGAGGAGCCATAGCTTGGAGTAGGTTTG
GCTTTGGTTGAAATAAGAATTTAGCCTGTATGTACTGCTTTAACTCCTGGAAGAATGACAGATGACAAAGATGTGCTTCGAGATGTGTGG
TTTGGACGAATTCCAACTTGTTTCACGCTATATCAGGATGAGATAACTGAAAGGGAAGCAGAACCATACTATGCATTATCCAATTGGTTT
GCTATTTGATCTTCTTGCATCAAGTTCAGCTCTTCCTTGGAACATCACAGTACATTTTAAGAGTTTTCCAGAAAAAGACCTTCTGCACTG
TCCATCTAAGGATGCAATTGAAGCTCATTTTATGTCATGTATGAAAGAAGCTGATGCTTTAAAACATAAAAGTCAAGTAATCAATGAAAT
GCAGAAAAAAGATCACAAGCAACTCTGGATGGGATTGCAAAATGGATTGCCAGCAGTGAGTATCCCTGTTGCACTCTCAAACCAAGGGTT
GCCAATAGGACTGCAGTTTATTGGACGTGCGTTTTGTGACCAGCAGCTTCTTACAGTAGCCAAATGGTTTGAAAAACAAGTACAGTTTCC
TGTTATTCAACTTCAAGAACTCATGGATGATTGTTCAGCAGTCCTTGAAAATGAAAAGTTAGCCTCTGTCTCTCTAAAACAGTAAACATA
TCTTACAAATTAAAATGACTTTTAGGCTGGGTGCAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGAGCGGATCATGA
GGTCAGAAGATCTAGAACAGCCTGGTCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGCTTAGTGGCGGGCATC
TGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCTGGAGGTGGAGGTTGCAGTGAGCCGAGATCATGCCACTGCA
CTGCACTCCAGCCTGGGTGACAAAGCAAGACTGTGTCTCAAAATAAATAAATAAAATAAAATAAAATGACGTACAGAGATTCTATATTCT
AGAGAGTCAAATGGTCTTGCTCAATTCTTGTAATTAGGTTCTTGTTAATACAGTCATTCCATGGAATTACTTTTTAAAATTCCTGTGACA
ATTAATAATAAATAACGTGTCAGCATTTAGTAAGCATCCACTAAGTGTACAATACTTCTACAATAACACAAGATACCTGTTCCTCAAAGA
CAATGCATTCTGCCATAATGTTCATTAAAGAGTTTACAGTAAAAATAAGATTAGGGATAAACTTCTCAAAAATTGTACATCTGTGTAACT
AAAGCACTAACAAAAACATGAATAGTCCTTCTAGAGGTAACTTGGATAGCCTAGGCAGGCAACTTATCATGTGGTGAAGGCCGCCTCAGG
GGTTGTTAAAAATGCACAGAAACAATTGAGTGCGATTATTGGCTTCTGAGCGCTGAGCAGAGCAGGTGGAAGAGGAACTTTGAGCACAGG
AGGAAATGCAACCAGTCAGGGCCCAGAATCATGCAAATCTCAGGGGTATGCCTCTCTGGGGAGGAGCTCCACTTGCAGGGACTCCTTTTA
TTTCCCTAAGAAAGAGCTGAAATGACTGAGAACTTTCCTTTCCTCCTTAGAGTTACAATTTTACTTCTGCTATTCCGGAGCCCATGCCTA
GAAGCCAGAACAACTCCATGTTACACTGAGTTCATGCTCCTATTTACTGATCACAAATGAGCTCATTAATGTCATCGAAACATTTATTGT
AACCTAACAGACCATCACAGATTGGAAACTTGGTAGATAGCAGAGCATGGTATTAGTGAAAAAGGTTCAAAATACACAAGTAACATACAC
TCTGAAAAACATGCAGATAATTTGCTGATGAAGCAGAAGAGGGGATGCGCATGGCAAGAACTTGCCTTACCCCAGATTCTCTATATCTCA
TGGTTTCCTTTTCCTCTTGACTGTCTTTACGAGTGTTTTTTATTTGGGACCCTCGAGCCCAGAGATATTAATGGATATCTGTATTCAATA
TTTGACAAAATCTAATGGAAACCATCCATTTACTCATGATAAGGCTTCATCACTGGATTTCTGTGTCTTCACTAGAACACCATTGTCATC
TCATATTGATCAGGTATTTTAATCTAGCACTTACATATTGTTGATAAATGAAAGCTGAATTGTTACTTAATAAATTCACTTTGTTTAGTA
AAAAAAAATTGTTTTCTAAATATGACGTTCATGAAGAGAAAATAATGAGTCAGAATCATCTGCAGAACCACTGGAATGTTTCATCGTCAC
CTGTTAGTTTTCATAAACAGTTTTCTGTCCTCTCTGAGATCCTCCCGCTCCCAAATACTCAACCTGATTAACTTCACATAAAAGTCTTAT
GTGCCAGGCTTAGTAATATTCCTATAGATTTTGACTCTGAATCCCTGAAAGAGGAAGAAATCCATGAGAGAAAATTGCATTACTTTATAG
CAAGAGGAAACCGTTTTAAGTTTTTTAATTGCTCAGACACCACAACATCCTAGATGGAGGAAACCATTTTAGTTGAAGGAGCAAATATGA
TGTCAAAAGCAAGTAAATAAACAAACCGTTGCCCCAATCTGTTTTTATGTAATGAATTTAAAAAAAAAGAGAGAGAGAGAGAGATGGGCT
CTCCCTGTGTTGCCCAGGCTAGTCTCAAACTCCTGGGCTCAAGTGATCTGCCTCCCTCAGCCTCCCAAAGTGCTGAGATTAAAGACGTGA
GCCACCACACCTGGCCGAAATAATAATATTCAATATTATATATTCAATGATATTATTCAGTATTCAATATTATTTCAAATAATATTAAAT
CTCTTGTTCCTGTATCTCTACATGAGCTGCACTAATAATTTGAATCTGGAAATTAAAAAGTGAAACATTTACCGTTCTCATATACTGATA
CCCAACTACCATGAAATGATACCTAATTTGTTTTTCTTTTCTCTTCATTTTTACTCTTAATCTAGTAGGTCTCATTTTGCCAAGTCACTG

>7600_7600_1_ATG5-QRSL1_ATG5_chr6_106727535_ENST00000369070_QRSL1_chr6_107113656_ENST00000369046_length(amino acids)=162AA_BP=89
MKGKQNHTMHYPIGLLFDLLASSSALPWNITVHFKSFPEKDLLHCPSKDAIEAHFMSCMKEADALKHKSQVINEMQKKDHKQLWMGLQNG

--------------------------------------------------------------
>7600_7600_2_ATG5-QRSL1_ATG5_chr6_106727535_ENST00000369076_QRSL1_chr6_107113656_ENST00000369046_length(transcript)=3438nt_BP=802nt
CTGGACTTGTGGTGCGCTGCCAGGGCTCCGCAGCGTTGCCGGTTGTATTCGCTGGATACCAGAGGGCGGAAGTGCAGCAGGGTTCAGCTC
CGACCTCCGCGCCGGTGCTTTTTGCGGCTGCGCGGGCTTCCTGGAGTCCTGCTACCGCGTCCCCGCAGGACAGTGTGTCAGGCGGGCAGC
TTGCCCCGCCGCCCCACCGGAGCGCGGAATCTGGGCGTCCCCACCAGTGCGGGGAGCCGGAAGGAGGAGCCATAGCTTGGAGTAGGTTTG
GCTTTGGTTGAAATAAGAATTTAGCCTGTATGTACTGCTTTAACTCCTGGAAGAATGACAGATGACAAAGATGTGCTTCGAGATGTGTGG
TTTGGACGAATTCCAACTTGTTTCACGCTATATCAGGATGAGATAACTGAAAGGGAAGCAGAACCATACTATTTGCTTTTGCCAAGAGTA
AGTTATTTGACGTTGGTAACTGACAAAGTGAAAAAGCACTTTCAGAAGGTTATGAGACAAGAAGACATTAGTGAGATATGGTTTGAATAT
GAAGGCACACCACTGAAATGGCATTATCCAATTGGTTTGCTATTTGATCTTCTTGCATCAAGTTCAGCTCTTCCTTGGAACATCACAGTA
CATTTTAAGAGTTTTCCAGAAAAAGACCTTCTGCACTGTCCATCTAAGGATGCAATTGAAGCTCATTTTATGTCATGTATGAAAGAAGCT
GATGCTTTAAAACATAAAAGTCAAGTAATCAATGAAATGCAGAAAAAAGATCACAAGCAACTCTGGATGGGATTGCAAAATGGATTGCCA
GCAGTGAGTATCCCTGTTGCACTCTCAAACCAAGGGTTGCCAATAGGACTGCAGTTTATTGGACGTGCGTTTTGTGACCAGCAGCTTCTT
ACAGTAGCCAAATGGTTTGAAAAACAAGTACAGTTTCCTGTTATTCAACTTCAAGAACTCATGGATGATTGTTCAGCAGTCCTTGAAAAT
GAAAAGTTAGCCTCTGTCTCTCTAAAACAGTAAACATATCTTACAAATTAAAATGACTTTTAGGCTGGGTGCAGTGGCTCACACCTGTAA
TCCCAGCACTTTGGGAGGCCAAGGCGAGCGGATCATGAGGTCAGAAGATCTAGAACAGCCTGGTCAACATGGTGAAACCCCGTCTCTACT
AAAAATACAAAAATTAGCCAGGCTTAGTGGCGGGCATCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCTGG
AGGTGGAGGTTGCAGTGAGCCGAGATCATGCCACTGCACTGCACTCCAGCCTGGGTGACAAAGCAAGACTGTGTCTCAAAATAAATAAAT
AAAATAAAATAAAATGACGTACAGAGATTCTATATTCTAGAGAGTCAAATGGTCTTGCTCAATTCTTGTAATTAGGTTCTTGTTAATACA
GTCATTCCATGGAATTACTTTTTAAAATTCCTGTGACAATTAATAATAAATAACGTGTCAGCATTTAGTAAGCATCCACTAAGTGTACAA
TACTTCTACAATAACACAAGATACCTGTTCCTCAAAGACAATGCATTCTGCCATAATGTTCATTAAAGAGTTTACAGTAAAAATAAGATT
AGGGATAAACTTCTCAAAAATTGTACATCTGTGTAACTAAAGCACTAACAAAAACATGAATAGTCCTTCTAGAGGTAACTTGGATAGCCT
AGGCAGGCAACTTATCATGTGGTGAAGGCCGCCTCAGGGGTTGTTAAAAATGCACAGAAACAATTGAGTGCGATTATTGGCTTCTGAGCG
CTGAGCAGAGCAGGTGGAAGAGGAACTTTGAGCACAGGAGGAAATGCAACCAGTCAGGGCCCAGAATCATGCAAATCTCAGGGGTATGCC
TCTCTGGGGAGGAGCTCCACTTGCAGGGACTCCTTTTATTTCCCTAAGAAAGAGCTGAAATGACTGAGAACTTTCCTTTCCTCCTTAGAG
TTACAATTTTACTTCTGCTATTCCGGAGCCCATGCCTAGAAGCCAGAACAACTCCATGTTACACTGAGTTCATGCTCCTATTTACTGATC
ACAAATGAGCTCATTAATGTCATCGAAACATTTATTGTAACCTAACAGACCATCACAGATTGGAAACTTGGTAGATAGCAGAGCATGGTA
TTAGTGAAAAAGGTTCAAAATACACAAGTAACATACACTCTGAAAAACATGCAGATAATTTGCTGATGAAGCAGAAGAGGGGATGCGCAT
GGCAAGAACTTGCCTTACCCCAGATTCTCTATATCTCATGGTTTCCTTTTCCTCTTGACTGTCTTTACGAGTGTTTTTTATTTGGGACCC
TCGAGCCCAGAGATATTAATGGATATCTGTATTCAATATTTGACAAAATCTAATGGAAACCATCCATTTACTCATGATAAGGCTTCATCA
CTGGATTTCTGTGTCTTCACTAGAACACCATTGTCATCTCATATTGATCAGGTATTTTAATCTAGCACTTACATATTGTTGATAAATGAA
AGCTGAATTGTTACTTAATAAATTCACTTTGTTTAGTAAAAAAAAATTGTTTTCTAAATATGACGTTCATGAAGAGAAAATAATGAGTCA
GAATCATCTGCAGAACCACTGGAATGTTTCATCGTCACCTGTTAGTTTTCATAAACAGTTTTCTGTCCTCTCTGAGATCCTCCCGCTCCC
AAATACTCAACCTGATTAACTTCACATAAAAGTCTTATGTGCCAGGCTTAGTAATATTCCTATAGATTTTGACTCTGAATCCCTGAAAGA
GGAAGAAATCCATGAGAGAAAATTGCATTACTTTATAGCAAGAGGAAACCGTTTTAAGTTTTTTAATTGCTCAGACACCACAACATCCTA
GATGGAGGAAACCATTTTAGTTGAAGGAGCAAATATGATGTCAAAAGCAAGTAAATAAACAAACCGTTGCCCCAATCTGTTTTTATGTAA
TGAATTTAAAAAAAAAGAGAGAGAGAGAGAGATGGGCTCTCCCTGTGTTGCCCAGGCTAGTCTCAAACTCCTGGGCTCAAGTGATCTGCC
TCCCTCAGCCTCCCAAAGTGCTGAGATTAAAGACGTGAGCCACCACACCTGGCCGAAATAATAATATTCAATATTATATATTCAATGATA
TTATTCAGTATTCAATATTATTTCAAATAATATTAAATCTCTTGTTCCTGTATCTCTACATGAGCTGCACTAATAATTTGAATCTGGAAA
TTAAAAAGTGAAACATTTACCGTTCTCATATACTGATACCCAACTACCATGAAATGATACCTAATTTGTTTTTCTTTTCTCTTCATTTTT
ACTCTTAATCTAGTAGGTCTCATTTTGCCAAGTCACTGTCTGGGAATTTAAGTGGCAAATACTTTCTTTGTCTCAGCTAATTAAACTCTA

>7600_7600_2_ATG5-QRSL1_ATG5_chr6_106727535_ENST00000369076_QRSL1_chr6_107113656_ENST00000369046_length(amino acids)=232AA_BP=159
MTDDKDVLRDVWFGRIPTCFTLYQDEITEREAEPYYLLLPRVSYLTLVTDKVKKHFQKVMRQEDISEIWFEYEGTPLKWHYPIGLLFDLL
ASSSALPWNITVHFKSFPEKDLLHCPSKDAIEAHFMSCMKEADALKHKSQVINEMQKKDHKQLWMGLQNGLPAVSIPVALSNQGLPIGLQ

--------------------------------------------------------------
>7600_7600_3_ATG5-QRSL1_ATG5_chr6_106727536_ENST00000369070_QRSL1_chr6_107113657_ENST00000369046_length(transcript)=3310nt_BP=674nt
CTGGACTTGTGGTGCGCTGCCAGGGCTCCGCAGCGTTGCCGGTTGTATTCGCTGGATACCAGAGGGCGGAAGTGCAGCAGGGTTCAGCTC
CGACCTCCGCGCCGGTGCTTTTTGCGGCTGCGCGGGCTTCCTGGAGTCCTGCTACCGCGTCCCCGCAGGACAGTGTGTCAGGCGGGCAGC
TTGCCCCGCCGCCCCACCGGAGCGCGGAATCTGGGCGTCCCCACCAGTGCGGGGAGCCGGAAGGAGGAGCCATAGCTTGGAGTAGGTTTG
GCTTTGGTTGAAATAAGAATTTAGCCTGTATGTACTGCTTTAACTCCTGGAAGAATGACAGATGACAAAGATGTGCTTCGAGATGTGTGG
TTTGGACGAATTCCAACTTGTTTCACGCTATATCAGGATGAGATAACTGAAAGGGAAGCAGAACCATACTATGCATTATCCAATTGGTTT
GCTATTTGATCTTCTTGCATCAAGTTCAGCTCTTCCTTGGAACATCACAGTACATTTTAAGAGTTTTCCAGAAAAAGACCTTCTGCACTG
TCCATCTAAGGATGCAATTGAAGCTCATTTTATGTCATGTATGAAAGAAGCTGATGCTTTAAAACATAAAAGTCAAGTAATCAATGAAAT
GCAGAAAAAAGATCACAAGCAACTCTGGATGGGATTGCAAAATGGATTGCCAGCAGTGAGTATCCCTGTTGCACTCTCAAACCAAGGGTT
GCCAATAGGACTGCAGTTTATTGGACGTGCGTTTTGTGACCAGCAGCTTCTTACAGTAGCCAAATGGTTTGAAAAACAAGTACAGTTTCC
TGTTATTCAACTTCAAGAACTCATGGATGATTGTTCAGCAGTCCTTGAAAATGAAAAGTTAGCCTCTGTCTCTCTAAAACAGTAAACATA
TCTTACAAATTAAAATGACTTTTAGGCTGGGTGCAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGAGCGGATCATGA
GGTCAGAAGATCTAGAACAGCCTGGTCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGCTTAGTGGCGGGCATC
TGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCTGGAGGTGGAGGTTGCAGTGAGCCGAGATCATGCCACTGCA
CTGCACTCCAGCCTGGGTGACAAAGCAAGACTGTGTCTCAAAATAAATAAATAAAATAAAATAAAATGACGTACAGAGATTCTATATTCT
AGAGAGTCAAATGGTCTTGCTCAATTCTTGTAATTAGGTTCTTGTTAATACAGTCATTCCATGGAATTACTTTTTAAAATTCCTGTGACA
ATTAATAATAAATAACGTGTCAGCATTTAGTAAGCATCCACTAAGTGTACAATACTTCTACAATAACACAAGATACCTGTTCCTCAAAGA
CAATGCATTCTGCCATAATGTTCATTAAAGAGTTTACAGTAAAAATAAGATTAGGGATAAACTTCTCAAAAATTGTACATCTGTGTAACT
AAAGCACTAACAAAAACATGAATAGTCCTTCTAGAGGTAACTTGGATAGCCTAGGCAGGCAACTTATCATGTGGTGAAGGCCGCCTCAGG
GGTTGTTAAAAATGCACAGAAACAATTGAGTGCGATTATTGGCTTCTGAGCGCTGAGCAGAGCAGGTGGAAGAGGAACTTTGAGCACAGG
AGGAAATGCAACCAGTCAGGGCCCAGAATCATGCAAATCTCAGGGGTATGCCTCTCTGGGGAGGAGCTCCACTTGCAGGGACTCCTTTTA
TTTCCCTAAGAAAGAGCTGAAATGACTGAGAACTTTCCTTTCCTCCTTAGAGTTACAATTTTACTTCTGCTATTCCGGAGCCCATGCCTA
GAAGCCAGAACAACTCCATGTTACACTGAGTTCATGCTCCTATTTACTGATCACAAATGAGCTCATTAATGTCATCGAAACATTTATTGT
AACCTAACAGACCATCACAGATTGGAAACTTGGTAGATAGCAGAGCATGGTATTAGTGAAAAAGGTTCAAAATACACAAGTAACATACAC
TCTGAAAAACATGCAGATAATTTGCTGATGAAGCAGAAGAGGGGATGCGCATGGCAAGAACTTGCCTTACCCCAGATTCTCTATATCTCA
TGGTTTCCTTTTCCTCTTGACTGTCTTTACGAGTGTTTTTTATTTGGGACCCTCGAGCCCAGAGATATTAATGGATATCTGTATTCAATA
TTTGACAAAATCTAATGGAAACCATCCATTTACTCATGATAAGGCTTCATCACTGGATTTCTGTGTCTTCACTAGAACACCATTGTCATC
TCATATTGATCAGGTATTTTAATCTAGCACTTACATATTGTTGATAAATGAAAGCTGAATTGTTACTTAATAAATTCACTTTGTTTAGTA
AAAAAAAATTGTTTTCTAAATATGACGTTCATGAAGAGAAAATAATGAGTCAGAATCATCTGCAGAACCACTGGAATGTTTCATCGTCAC
CTGTTAGTTTTCATAAACAGTTTTCTGTCCTCTCTGAGATCCTCCCGCTCCCAAATACTCAACCTGATTAACTTCACATAAAAGTCTTAT
GTGCCAGGCTTAGTAATATTCCTATAGATTTTGACTCTGAATCCCTGAAAGAGGAAGAAATCCATGAGAGAAAATTGCATTACTTTATAG
CAAGAGGAAACCGTTTTAAGTTTTTTAATTGCTCAGACACCACAACATCCTAGATGGAGGAAACCATTTTAGTTGAAGGAGCAAATATGA
TGTCAAAAGCAAGTAAATAAACAAACCGTTGCCCCAATCTGTTTTTATGTAATGAATTTAAAAAAAAAGAGAGAGAGAGAGAGATGGGCT
CTCCCTGTGTTGCCCAGGCTAGTCTCAAACTCCTGGGCTCAAGTGATCTGCCTCCCTCAGCCTCCCAAAGTGCTGAGATTAAAGACGTGA
GCCACCACACCTGGCCGAAATAATAATATTCAATATTATATATTCAATGATATTATTCAGTATTCAATATTATTTCAAATAATATTAAAT
CTCTTGTTCCTGTATCTCTACATGAGCTGCACTAATAATTTGAATCTGGAAATTAAAAAGTGAAACATTTACCGTTCTCATATACTGATA
CCCAACTACCATGAAATGATACCTAATTTGTTTTTCTTTTCTCTTCATTTTTACTCTTAATCTAGTAGGTCTCATTTTGCCAAGTCACTG

>7600_7600_3_ATG5-QRSL1_ATG5_chr6_106727536_ENST00000369070_QRSL1_chr6_107113657_ENST00000369046_length(amino acids)=162AA_BP=89
MKGKQNHTMHYPIGLLFDLLASSSALPWNITVHFKSFPEKDLLHCPSKDAIEAHFMSCMKEADALKHKSQVINEMQKKDHKQLWMGLQNG

--------------------------------------------------------------
>7600_7600_4_ATG5-QRSL1_ATG5_chr6_106727536_ENST00000369076_QRSL1_chr6_107113657_ENST00000369046_length(transcript)=3438nt_BP=802nt
CTGGACTTGTGGTGCGCTGCCAGGGCTCCGCAGCGTTGCCGGTTGTATTCGCTGGATACCAGAGGGCGGAAGTGCAGCAGGGTTCAGCTC
CGACCTCCGCGCCGGTGCTTTTTGCGGCTGCGCGGGCTTCCTGGAGTCCTGCTACCGCGTCCCCGCAGGACAGTGTGTCAGGCGGGCAGC
TTGCCCCGCCGCCCCACCGGAGCGCGGAATCTGGGCGTCCCCACCAGTGCGGGGAGCCGGAAGGAGGAGCCATAGCTTGGAGTAGGTTTG
GCTTTGGTTGAAATAAGAATTTAGCCTGTATGTACTGCTTTAACTCCTGGAAGAATGACAGATGACAAAGATGTGCTTCGAGATGTGTGG
TTTGGACGAATTCCAACTTGTTTCACGCTATATCAGGATGAGATAACTGAAAGGGAAGCAGAACCATACTATTTGCTTTTGCCAAGAGTA
AGTTATTTGACGTTGGTAACTGACAAAGTGAAAAAGCACTTTCAGAAGGTTATGAGACAAGAAGACATTAGTGAGATATGGTTTGAATAT
GAAGGCACACCACTGAAATGGCATTATCCAATTGGTTTGCTATTTGATCTTCTTGCATCAAGTTCAGCTCTTCCTTGGAACATCACAGTA
CATTTTAAGAGTTTTCCAGAAAAAGACCTTCTGCACTGTCCATCTAAGGATGCAATTGAAGCTCATTTTATGTCATGTATGAAAGAAGCT
GATGCTTTAAAACATAAAAGTCAAGTAATCAATGAAATGCAGAAAAAAGATCACAAGCAACTCTGGATGGGATTGCAAAATGGATTGCCA
GCAGTGAGTATCCCTGTTGCACTCTCAAACCAAGGGTTGCCAATAGGACTGCAGTTTATTGGACGTGCGTTTTGTGACCAGCAGCTTCTT
ACAGTAGCCAAATGGTTTGAAAAACAAGTACAGTTTCCTGTTATTCAACTTCAAGAACTCATGGATGATTGTTCAGCAGTCCTTGAAAAT
GAAAAGTTAGCCTCTGTCTCTCTAAAACAGTAAACATATCTTACAAATTAAAATGACTTTTAGGCTGGGTGCAGTGGCTCACACCTGTAA
TCCCAGCACTTTGGGAGGCCAAGGCGAGCGGATCATGAGGTCAGAAGATCTAGAACAGCCTGGTCAACATGGTGAAACCCCGTCTCTACT
AAAAATACAAAAATTAGCCAGGCTTAGTGGCGGGCATCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCTGG
AGGTGGAGGTTGCAGTGAGCCGAGATCATGCCACTGCACTGCACTCCAGCCTGGGTGACAAAGCAAGACTGTGTCTCAAAATAAATAAAT
AAAATAAAATAAAATGACGTACAGAGATTCTATATTCTAGAGAGTCAAATGGTCTTGCTCAATTCTTGTAATTAGGTTCTTGTTAATACA
GTCATTCCATGGAATTACTTTTTAAAATTCCTGTGACAATTAATAATAAATAACGTGTCAGCATTTAGTAAGCATCCACTAAGTGTACAA
TACTTCTACAATAACACAAGATACCTGTTCCTCAAAGACAATGCATTCTGCCATAATGTTCATTAAAGAGTTTACAGTAAAAATAAGATT
AGGGATAAACTTCTCAAAAATTGTACATCTGTGTAACTAAAGCACTAACAAAAACATGAATAGTCCTTCTAGAGGTAACTTGGATAGCCT
AGGCAGGCAACTTATCATGTGGTGAAGGCCGCCTCAGGGGTTGTTAAAAATGCACAGAAACAATTGAGTGCGATTATTGGCTTCTGAGCG
CTGAGCAGAGCAGGTGGAAGAGGAACTTTGAGCACAGGAGGAAATGCAACCAGTCAGGGCCCAGAATCATGCAAATCTCAGGGGTATGCC
TCTCTGGGGAGGAGCTCCACTTGCAGGGACTCCTTTTATTTCCCTAAGAAAGAGCTGAAATGACTGAGAACTTTCCTTTCCTCCTTAGAG
TTACAATTTTACTTCTGCTATTCCGGAGCCCATGCCTAGAAGCCAGAACAACTCCATGTTACACTGAGTTCATGCTCCTATTTACTGATC
ACAAATGAGCTCATTAATGTCATCGAAACATTTATTGTAACCTAACAGACCATCACAGATTGGAAACTTGGTAGATAGCAGAGCATGGTA
TTAGTGAAAAAGGTTCAAAATACACAAGTAACATACACTCTGAAAAACATGCAGATAATTTGCTGATGAAGCAGAAGAGGGGATGCGCAT
GGCAAGAACTTGCCTTACCCCAGATTCTCTATATCTCATGGTTTCCTTTTCCTCTTGACTGTCTTTACGAGTGTTTTTTATTTGGGACCC
TCGAGCCCAGAGATATTAATGGATATCTGTATTCAATATTTGACAAAATCTAATGGAAACCATCCATTTACTCATGATAAGGCTTCATCA
CTGGATTTCTGTGTCTTCACTAGAACACCATTGTCATCTCATATTGATCAGGTATTTTAATCTAGCACTTACATATTGTTGATAAATGAA
AGCTGAATTGTTACTTAATAAATTCACTTTGTTTAGTAAAAAAAAATTGTTTTCTAAATATGACGTTCATGAAGAGAAAATAATGAGTCA
GAATCATCTGCAGAACCACTGGAATGTTTCATCGTCACCTGTTAGTTTTCATAAACAGTTTTCTGTCCTCTCTGAGATCCTCCCGCTCCC
AAATACTCAACCTGATTAACTTCACATAAAAGTCTTATGTGCCAGGCTTAGTAATATTCCTATAGATTTTGACTCTGAATCCCTGAAAGA
GGAAGAAATCCATGAGAGAAAATTGCATTACTTTATAGCAAGAGGAAACCGTTTTAAGTTTTTTAATTGCTCAGACACCACAACATCCTA
GATGGAGGAAACCATTTTAGTTGAAGGAGCAAATATGATGTCAAAAGCAAGTAAATAAACAAACCGTTGCCCCAATCTGTTTTTATGTAA
TGAATTTAAAAAAAAAGAGAGAGAGAGAGAGATGGGCTCTCCCTGTGTTGCCCAGGCTAGTCTCAAACTCCTGGGCTCAAGTGATCTGCC
TCCCTCAGCCTCCCAAAGTGCTGAGATTAAAGACGTGAGCCACCACACCTGGCCGAAATAATAATATTCAATATTATATATTCAATGATA
TTATTCAGTATTCAATATTATTTCAAATAATATTAAATCTCTTGTTCCTGTATCTCTACATGAGCTGCACTAATAATTTGAATCTGGAAA
TTAAAAAGTGAAACATTTACCGTTCTCATATACTGATACCCAACTACCATGAAATGATACCTAATTTGTTTTTCTTTTCTCTTCATTTTT
ACTCTTAATCTAGTAGGTCTCATTTTGCCAAGTCACTGTCTGGGAATTTAAGTGGCAAATACTTTCTTTGTCTCAGCTAATTAAACTCTA

>7600_7600_4_ATG5-QRSL1_ATG5_chr6_106727536_ENST00000369076_QRSL1_chr6_107113657_ENST00000369046_length(amino acids)=232AA_BP=159
MTDDKDVLRDVWFGRIPTCFTLYQDEITEREAEPYYLLLPRVSYLTLVTDKVKKHFQKVMRQEDISEIWFEYEGTPLKWHYPIGLLFDLL
ASSSALPWNITVHFKSFPEKDLLHCPSKDAIEAHFMSCMKEADALKHKSQVINEMQKKDHKQLWMGLQNGLPAVSIPVALSNQGLPIGLQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ATG5-QRSL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATG5-QRSL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATG5-QRSL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource