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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RPL18A-FCHO1 (FusionGDB2 ID:76026)

Fusion Gene Summary for RPL18A-FCHO1

check button Fusion gene summary
Fusion gene informationFusion gene name: RPL18A-FCHO1
Fusion gene ID: 76026
HgeneTgene
Gene symbol

RPL18A

FCHO1

Gene ID

6142

23149

Gene nameribosomal protein L18aFCH and mu domain containing endocytic adaptor 1
SynonymsL18A-
Cytomap

19p13.11

19p13.11

Type of geneprotein-codingprotein-coding
Description60S ribosomal protein L18alarge ribosomal subunit protein eL20ribosomal protein L18a-like proteinF-BAR domain only protein 1FCH domain only 1FCH domain only protein 1
Modification date2020031320200313
UniProtAcc.

O14526

Ensembl transtripts involved in fusion geneENST00000222247, ENST00000599898, 
ENST00000600147, ENST00000599870, 
ENST00000596536, ENST00000599236, 
ENST00000539407, ENST00000594202, 
ENST00000595033, ENST00000596951, 
ENST00000597512, ENST00000600676, 
ENST00000252771, ENST00000389133, 
Fusion gene scores* DoF score4 X 3 X 3=365 X 6 X 3=90
# samples 45
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/90*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPL18A [Title/Abstract] AND FCHO1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRPL18A(17970783)-FCHO1(17865125), # samples:1
RPL18A(17970783)-FCHO1(17873570), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPL18A

GO:0002181

cytoplasmic translation

25957688


check buttonFusion gene breakpoints across RPL18A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FCHO1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-29-1694RPL18Achr19

17970783

+FCHO1chr19

17865125

+
ChimerDB4OVTCGA-29-1694RPL18Achr19

17970783

+FCHO1chr19

17873570

+


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Fusion Gene ORF analysis for RPL18A-FCHO1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000222247ENST00000596536RPL18Achr19

17970783

+FCHO1chr19

17873570

+
5CDS-3UTRENST00000222247ENST00000599236RPL18Achr19

17970783

+FCHO1chr19

17865125

+
5CDS-3UTRENST00000222247ENST00000599236RPL18Achr19

17970783

+FCHO1chr19

17873570

+
5CDS-3UTRENST00000599898ENST00000596536RPL18Achr19

17970783

+FCHO1chr19

17873570

+
5CDS-3UTRENST00000599898ENST00000599236RPL18Achr19

17970783

+FCHO1chr19

17865125

+
5CDS-3UTRENST00000599898ENST00000599236RPL18Achr19

17970783

+FCHO1chr19

17873570

+
5CDS-3UTRENST00000600147ENST00000596536RPL18Achr19

17970783

+FCHO1chr19

17873570

+
5CDS-3UTRENST00000600147ENST00000599236RPL18Achr19

17970783

+FCHO1chr19

17865125

+
5CDS-3UTRENST00000600147ENST00000599236RPL18Achr19

17970783

+FCHO1chr19

17873570

+
5CDS-5UTRENST00000222247ENST00000539407RPL18Achr19

17970783

+FCHO1chr19

17865125

+
5CDS-5UTRENST00000222247ENST00000539407RPL18Achr19

17970783

+FCHO1chr19

17873570

+
5CDS-5UTRENST00000222247ENST00000594202RPL18Achr19

17970783

+FCHO1chr19

17865125

+
5CDS-5UTRENST00000222247ENST00000595033RPL18Achr19

17970783

+FCHO1chr19

17865125

+
5CDS-5UTRENST00000222247ENST00000595033RPL18Achr19

17970783

+FCHO1chr19

17873570

+
5CDS-5UTRENST00000222247ENST00000596536RPL18Achr19

17970783

+FCHO1chr19

17865125

+
5CDS-5UTRENST00000222247ENST00000596951RPL18Achr19

17970783

+FCHO1chr19

17873570

+
5CDS-5UTRENST00000222247ENST00000597512RPL18Achr19

17970783

+FCHO1chr19

17873570

+
5CDS-5UTRENST00000222247ENST00000600676RPL18Achr19

17970783

+FCHO1chr19

17865125

+
5CDS-5UTRENST00000599898ENST00000539407RPL18Achr19

17970783

+FCHO1chr19

17865125

+
5CDS-5UTRENST00000599898ENST00000539407RPL18Achr19

17970783

+FCHO1chr19

17873570

+
5CDS-5UTRENST00000599898ENST00000594202RPL18Achr19

17970783

+FCHO1chr19

17865125

+
5CDS-5UTRENST00000599898ENST00000595033RPL18Achr19

17970783

+FCHO1chr19

17865125

+
5CDS-5UTRENST00000599898ENST00000595033RPL18Achr19

17970783

+FCHO1chr19

17873570

+
5CDS-5UTRENST00000599898ENST00000596536RPL18Achr19

17970783

+FCHO1chr19

17865125

+
5CDS-5UTRENST00000599898ENST00000596951RPL18Achr19

17970783

+FCHO1chr19

17873570

+
5CDS-5UTRENST00000599898ENST00000597512RPL18Achr19

17970783

+FCHO1chr19

17873570

+
5CDS-5UTRENST00000599898ENST00000600676RPL18Achr19

17970783

+FCHO1chr19

17865125

+
5CDS-5UTRENST00000600147ENST00000539407RPL18Achr19

17970783

+FCHO1chr19

17865125

+
5CDS-5UTRENST00000600147ENST00000539407RPL18Achr19

17970783

+FCHO1chr19

17873570

+
5CDS-5UTRENST00000600147ENST00000594202RPL18Achr19

17970783

+FCHO1chr19

17865125

+
5CDS-5UTRENST00000600147ENST00000595033RPL18Achr19

17970783

+FCHO1chr19

17865125

+
5CDS-5UTRENST00000600147ENST00000595033RPL18Achr19

17970783

+FCHO1chr19

17873570

+
5CDS-5UTRENST00000600147ENST00000596536RPL18Achr19

17970783

+FCHO1chr19

17865125

+
5CDS-5UTRENST00000600147ENST00000596951RPL18Achr19

17970783

+FCHO1chr19

17873570

+
5CDS-5UTRENST00000600147ENST00000597512RPL18Achr19

17970783

+FCHO1chr19

17873570

+
5CDS-5UTRENST00000600147ENST00000600676RPL18Achr19

17970783

+FCHO1chr19

17865125

+
5CDS-intronENST00000222247ENST00000252771RPL18Achr19

17970783

+FCHO1chr19

17865125

+
5CDS-intronENST00000222247ENST00000389133RPL18Achr19

17970783

+FCHO1chr19

17865125

+
5CDS-intronENST00000222247ENST00000596951RPL18Achr19

17970783

+FCHO1chr19

17865125

+
5CDS-intronENST00000222247ENST00000597512RPL18Achr19

17970783

+FCHO1chr19

17865125

+
5CDS-intronENST00000599898ENST00000252771RPL18Achr19

17970783

+FCHO1chr19

17865125

+
5CDS-intronENST00000599898ENST00000389133RPL18Achr19

17970783

+FCHO1chr19

17865125

+
5CDS-intronENST00000599898ENST00000596951RPL18Achr19

17970783

+FCHO1chr19

17865125

+
5CDS-intronENST00000599898ENST00000597512RPL18Achr19

17970783

+FCHO1chr19

17865125

+
5CDS-intronENST00000600147ENST00000252771RPL18Achr19

17970783

+FCHO1chr19

17865125

+
5CDS-intronENST00000600147ENST00000389133RPL18Achr19

17970783

+FCHO1chr19

17865125

+
5CDS-intronENST00000600147ENST00000596951RPL18Achr19

17970783

+FCHO1chr19

17865125

+
5CDS-intronENST00000600147ENST00000597512RPL18Achr19

17970783

+FCHO1chr19

17865125

+
In-frameENST00000222247ENST00000252771RPL18Achr19

17970783

+FCHO1chr19

17873570

+
In-frameENST00000222247ENST00000389133RPL18Achr19

17970783

+FCHO1chr19

17873570

+
In-frameENST00000222247ENST00000594202RPL18Achr19

17970783

+FCHO1chr19

17873570

+
In-frameENST00000222247ENST00000600676RPL18Achr19

17970783

+FCHO1chr19

17873570

+
In-frameENST00000599898ENST00000252771RPL18Achr19

17970783

+FCHO1chr19

17873570

+
In-frameENST00000599898ENST00000389133RPL18Achr19

17970783

+FCHO1chr19

17873570

+
In-frameENST00000599898ENST00000594202RPL18Achr19

17970783

+FCHO1chr19

17873570

+
In-frameENST00000599898ENST00000600676RPL18Achr19

17970783

+FCHO1chr19

17873570

+
In-frameENST00000600147ENST00000252771RPL18Achr19

17970783

+FCHO1chr19

17873570

+
In-frameENST00000600147ENST00000389133RPL18Achr19

17970783

+FCHO1chr19

17873570

+
In-frameENST00000600147ENST00000594202RPL18Achr19

17970783

+FCHO1chr19

17873570

+
In-frameENST00000600147ENST00000600676RPL18Achr19

17970783

+FCHO1chr19

17873570

+
intron-3CDSENST00000599870ENST00000252771RPL18Achr19

17970783

+FCHO1chr19

17873570

+
intron-3CDSENST00000599870ENST00000389133RPL18Achr19

17970783

+FCHO1chr19

17873570

+
intron-3CDSENST00000599870ENST00000594202RPL18Achr19

17970783

+FCHO1chr19

17873570

+
intron-3CDSENST00000599870ENST00000600676RPL18Achr19

17970783

+FCHO1chr19

17873570

+
intron-3UTRENST00000599870ENST00000596536RPL18Achr19

17970783

+FCHO1chr19

17873570

+
intron-3UTRENST00000599870ENST00000599236RPL18Achr19

17970783

+FCHO1chr19

17865125

+
intron-3UTRENST00000599870ENST00000599236RPL18Achr19

17970783

+FCHO1chr19

17873570

+
intron-5UTRENST00000599870ENST00000539407RPL18Achr19

17970783

+FCHO1chr19

17865125

+
intron-5UTRENST00000599870ENST00000539407RPL18Achr19

17970783

+FCHO1chr19

17873570

+
intron-5UTRENST00000599870ENST00000594202RPL18Achr19

17970783

+FCHO1chr19

17865125

+
intron-5UTRENST00000599870ENST00000595033RPL18Achr19

17970783

+FCHO1chr19

17865125

+
intron-5UTRENST00000599870ENST00000595033RPL18Achr19

17970783

+FCHO1chr19

17873570

+
intron-5UTRENST00000599870ENST00000596536RPL18Achr19

17970783

+FCHO1chr19

17865125

+
intron-5UTRENST00000599870ENST00000596951RPL18Achr19

17970783

+FCHO1chr19

17873570

+
intron-5UTRENST00000599870ENST00000597512RPL18Achr19

17970783

+FCHO1chr19

17873570

+
intron-5UTRENST00000599870ENST00000600676RPL18Achr19

17970783

+FCHO1chr19

17865125

+
intron-intronENST00000599870ENST00000252771RPL18Achr19

17970783

+FCHO1chr19

17865125

+
intron-intronENST00000599870ENST00000389133RPL18Achr19

17970783

+FCHO1chr19

17865125

+
intron-intronENST00000599870ENST00000596951RPL18Achr19

17970783

+FCHO1chr19

17865125

+
intron-intronENST00000599870ENST00000597512RPL18Achr19

17970783

+FCHO1chr19

17865125

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for RPL18A-FCHO1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RPL18Achr1917970783+FCHO1chr1917865122+0.105435640.89456433
RPL18Achr1917970783+FCHO1chr1917873570+4.49E-101
RPL18Achr1917970783+FCHO1chr1917865122+0.105435640.89456433
RPL18Achr1917970783+FCHO1chr1917873570+4.49E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RPL18A-FCHO1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:17970783/chr19:17865125)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FCHO1

O14526

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. {ECO:0000269|PubMed:20448150}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFCHO1chr19:17970783chr19:17873570ENST00000252771127156_1959890.0Coiled coilOntology_term=ECO:0000255
TgeneFCHO1chr19:17970783chr19:17873570ENST00000389133127156_1959890.0Coiled coilOntology_term=ECO:0000255
TgeneFCHO1chr19:17970783chr19:17873570ENST00000539407228156_1959890.0Coiled coilOntology_term=ECO:0000255
TgeneFCHO1chr19:17970783chr19:17873570ENST00000594202329156_1959892.0Coiled coilOntology_term=ECO:0000255
TgeneFCHO1chr19:17970783chr19:17873570ENST00000595033127156_1950840.0Coiled coilOntology_term=ECO:0000255
TgeneFCHO1chr19:17970783chr19:17873570ENST00000596536329156_1959890.0Coiled coilOntology_term=ECO:0000255
TgeneFCHO1chr19:17970783chr19:17873570ENST00000596951127156_1959890.0Coiled coilOntology_term=ECO:0000255
TgeneFCHO1chr19:17970783chr19:17873570ENST00000600676228156_1959890.0Coiled coilOntology_term=ECO:0000255
TgeneFCHO1chr19:17970783chr19:17873570ENST00000252771127375_3789890.0Compositional biasNote=Poly-Ala
TgeneFCHO1chr19:17970783chr19:17873570ENST00000252771127465_4689890.0Compositional biasNote=Poly-Ser
TgeneFCHO1chr19:17970783chr19:17873570ENST00000252771127480_5619890.0Compositional biasNote=Pro-rich
TgeneFCHO1chr19:17970783chr19:17873570ENST00000252771127671_6749890.0Compositional biasNote=Poly-Pro
TgeneFCHO1chr19:17970783chr19:17873570ENST00000389133127375_3789890.0Compositional biasNote=Poly-Ala
TgeneFCHO1chr19:17970783chr19:17873570ENST00000389133127465_4689890.0Compositional biasNote=Poly-Ser
TgeneFCHO1chr19:17970783chr19:17873570ENST00000389133127480_5619890.0Compositional biasNote=Pro-rich
TgeneFCHO1chr19:17970783chr19:17873570ENST00000389133127671_6749890.0Compositional biasNote=Poly-Pro
TgeneFCHO1chr19:17970783chr19:17873570ENST00000539407228375_3789890.0Compositional biasNote=Poly-Ala
TgeneFCHO1chr19:17970783chr19:17873570ENST00000539407228465_4689890.0Compositional biasNote=Poly-Ser
TgeneFCHO1chr19:17970783chr19:17873570ENST00000539407228480_5619890.0Compositional biasNote=Pro-rich
TgeneFCHO1chr19:17970783chr19:17873570ENST00000539407228671_6749890.0Compositional biasNote=Poly-Pro
TgeneFCHO1chr19:17970783chr19:17873570ENST00000594202329375_3789892.0Compositional biasNote=Poly-Ala
TgeneFCHO1chr19:17970783chr19:17873570ENST00000594202329465_4689892.0Compositional biasNote=Poly-Ser
TgeneFCHO1chr19:17970783chr19:17873570ENST00000594202329480_5619892.0Compositional biasNote=Pro-rich
TgeneFCHO1chr19:17970783chr19:17873570ENST00000594202329671_6749892.0Compositional biasNote=Poly-Pro
TgeneFCHO1chr19:17970783chr19:17873570ENST00000595033127375_3780840.0Compositional biasNote=Poly-Ala
TgeneFCHO1chr19:17970783chr19:17873570ENST00000595033127465_4680840.0Compositional biasNote=Poly-Ser
TgeneFCHO1chr19:17970783chr19:17873570ENST00000595033127480_5610840.0Compositional biasNote=Pro-rich
TgeneFCHO1chr19:17970783chr19:17873570ENST00000595033127671_6740840.0Compositional biasNote=Poly-Pro
TgeneFCHO1chr19:17970783chr19:17873570ENST00000596536329375_3789890.0Compositional biasNote=Poly-Ala
TgeneFCHO1chr19:17970783chr19:17873570ENST00000596536329465_4689890.0Compositional biasNote=Poly-Ser
TgeneFCHO1chr19:17970783chr19:17873570ENST00000596536329480_5619890.0Compositional biasNote=Pro-rich
TgeneFCHO1chr19:17970783chr19:17873570ENST00000596536329671_6749890.0Compositional biasNote=Poly-Pro
TgeneFCHO1chr19:17970783chr19:17873570ENST00000596951127375_3789890.0Compositional biasNote=Poly-Ala
TgeneFCHO1chr19:17970783chr19:17873570ENST00000596951127465_4689890.0Compositional biasNote=Poly-Ser
TgeneFCHO1chr19:17970783chr19:17873570ENST00000596951127480_5619890.0Compositional biasNote=Pro-rich
TgeneFCHO1chr19:17970783chr19:17873570ENST00000596951127671_6749890.0Compositional biasNote=Poly-Pro
TgeneFCHO1chr19:17970783chr19:17873570ENST00000600676228375_3789890.0Compositional biasNote=Poly-Ala
TgeneFCHO1chr19:17970783chr19:17873570ENST00000600676228465_4689890.0Compositional biasNote=Poly-Ser
TgeneFCHO1chr19:17970783chr19:17873570ENST00000600676228480_5619890.0Compositional biasNote=Pro-rich
TgeneFCHO1chr19:17970783chr19:17873570ENST00000600676228671_6749890.0Compositional biasNote=Poly-Pro
TgeneFCHO1chr19:17970783chr19:17873570ENST00000252771127625_8889890.0DomainMHD
TgeneFCHO1chr19:17970783chr19:17873570ENST00000389133127625_8889890.0DomainMHD
TgeneFCHO1chr19:17970783chr19:17873570ENST00000539407228625_8889890.0DomainMHD
TgeneFCHO1chr19:17970783chr19:17873570ENST00000594202329625_8889892.0DomainMHD
TgeneFCHO1chr19:17970783chr19:17873570ENST000005950331271_2480840.0DomainF-BAR
TgeneFCHO1chr19:17970783chr19:17873570ENST00000595033127625_8880840.0DomainMHD
TgeneFCHO1chr19:17970783chr19:17873570ENST00000596536329625_8889890.0DomainMHD
TgeneFCHO1chr19:17970783chr19:17873570ENST00000596951127625_8889890.0DomainMHD
TgeneFCHO1chr19:17970783chr19:17873570ENST00000600676228625_8889890.0DomainMHD
TgeneFCHO1chr19:17970783chr19:17873570ENST000005950331271_2750840.0RegionNote=Mediates membrane-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFCHO1chr19:17970783chr19:17873570ENST000002527711271_2489890.0DomainF-BAR
TgeneFCHO1chr19:17970783chr19:17873570ENST000003891331271_2489890.0DomainF-BAR
TgeneFCHO1chr19:17970783chr19:17873570ENST000005394072281_2489890.0DomainF-BAR
TgeneFCHO1chr19:17970783chr19:17873570ENST000005942023291_2489892.0DomainF-BAR
TgeneFCHO1chr19:17970783chr19:17873570ENST000005965363291_2489890.0DomainF-BAR
TgeneFCHO1chr19:17970783chr19:17873570ENST000005969511271_2489890.0DomainF-BAR
TgeneFCHO1chr19:17970783chr19:17873570ENST000006006762281_2489890.0DomainF-BAR
TgeneFCHO1chr19:17970783chr19:17873570ENST000002527711271_2759890.0RegionNote=Mediates membrane-binding
TgeneFCHO1chr19:17970783chr19:17873570ENST000003891331271_2759890.0RegionNote=Mediates membrane-binding
TgeneFCHO1chr19:17970783chr19:17873570ENST000005394072281_2759890.0RegionNote=Mediates membrane-binding
TgeneFCHO1chr19:17970783chr19:17873570ENST000005942023291_2759892.0RegionNote=Mediates membrane-binding
TgeneFCHO1chr19:17970783chr19:17873570ENST000005965363291_2759890.0RegionNote=Mediates membrane-binding
TgeneFCHO1chr19:17970783chr19:17873570ENST000005969511271_2759890.0RegionNote=Mediates membrane-binding
TgeneFCHO1chr19:17970783chr19:17873570ENST000006006762281_2759890.0RegionNote=Mediates membrane-binding


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Fusion Gene Sequence for RPL18A-FCHO1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for RPL18A-FCHO1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RPL18A-FCHO1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RPL18A-FCHO1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource