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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATG5-SYNJ2 (FusionGDB2 ID:7605)

Fusion Gene Summary for ATG5-SYNJ2

check button Fusion gene summary
Fusion gene informationFusion gene name: ATG5-SYNJ2
Fusion gene ID: 7605
HgeneTgene
Gene symbol

ATG5

SYNJ2

Gene ID

9474

8871

Gene nameautophagy related 5synaptojanin 2
SynonymsAPG5|APG5-LIKE|APG5L|ASP|SCAR25|hAPG5INPP5H
Cytomap

6q21

6q25.3

Type of geneprotein-codingprotein-coding
Descriptionautophagy protein 5APG5 autophagy 5-likeATG5 autophagy related 5 homologapoptosis-specific proteinsynaptojanin-2inositol phosphate 5'-phosphatase 2inositol polyphosphate-5-phosphatase Hphosphoinositide 5-phosphatasesynaptic inositol 1,4,5-trisphosphate 5-phosphatase 2
Modification date2020031320200327
UniProtAcc

Q9H1Y0

.
Ensembl transtripts involved in fusion geneENST00000343245, ENST00000360666, 
ENST00000369070, ENST00000369076, 
ENST00000475645, 		ENST00000367112, 
ENST00000449859, ENST00000355585, 
ENST00000367121, ENST00000367122, 
Fusion gene scores* DoF score25 X 16 X 9=36008 X 8 X 6=384
# samples 298
** MAII scorelog2(29/3600*10)=-3.6338721012021
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/384*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATG5 [Title/Abstract] AND SYNJ2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATG5(106763976)-SYNJ2(158502141), # samples:3
Anticipated loss of major functional domain due to fusion event.ATG5-SYNJ2 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ATG5-SYNJ2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ATG5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SYNJ2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-66-2788-01AATG5chr6

106763976

-SYNJ2chr6

158502141

+
ChimerDB4LUSCTCGA-66-2788ATG5chr6

106763976

-SYNJ2chr6

158502141

+


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Fusion Gene ORF analysis for ATG5-SYNJ2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000343245ENST00000367112ATG5chr6

106763976

-SYNJ2chr6

158502141

+
5CDS-5UTRENST00000360666ENST00000367112ATG5chr6

106763976

-SYNJ2chr6

158502141

+
5CDS-5UTRENST00000369070ENST00000367112ATG5chr6

106763976

-SYNJ2chr6

158502141

+
5CDS-5UTRENST00000369076ENST00000367112ATG5chr6

106763976

-SYNJ2chr6

158502141

+
5CDS-intronENST00000343245ENST00000449859ATG5chr6

106763976

-SYNJ2chr6

158502141

+
5CDS-intronENST00000360666ENST00000449859ATG5chr6

106763976

-SYNJ2chr6

158502141

+
5CDS-intronENST00000369070ENST00000449859ATG5chr6

106763976

-SYNJ2chr6

158502141

+
5CDS-intronENST00000369076ENST00000449859ATG5chr6

106763976

-SYNJ2chr6

158502141

+
Frame-shiftENST00000343245ENST00000355585ATG5chr6

106763976

-SYNJ2chr6

158502141

+
Frame-shiftENST00000343245ENST00000367121ATG5chr6

106763976

-SYNJ2chr6

158502141

+
Frame-shiftENST00000343245ENST00000367122ATG5chr6

106763976

-SYNJ2chr6

158502141

+
Frame-shiftENST00000360666ENST00000355585ATG5chr6

106763976

-SYNJ2chr6

158502141

+
Frame-shiftENST00000360666ENST00000367121ATG5chr6

106763976

-SYNJ2chr6

158502141

+
Frame-shiftENST00000360666ENST00000367122ATG5chr6

106763976

-SYNJ2chr6

158502141

+
Frame-shiftENST00000369070ENST00000355585ATG5chr6

106763976

-SYNJ2chr6

158502141

+
Frame-shiftENST00000369070ENST00000367121ATG5chr6

106763976

-SYNJ2chr6

158502141

+
Frame-shiftENST00000369070ENST00000367122ATG5chr6

106763976

-SYNJ2chr6

158502141

+
In-frameENST00000369076ENST00000355585ATG5chr6

106763976

-SYNJ2chr6

158502141

+
In-frameENST00000369076ENST00000367121ATG5chr6

106763976

-SYNJ2chr6

158502141

+
In-frameENST00000369076ENST00000367122ATG5chr6

106763976

-SYNJ2chr6

158502141

+
intron-3CDSENST00000475645ENST00000355585ATG5chr6

106763976

-SYNJ2chr6

158502141

+
intron-3CDSENST00000475645ENST00000367121ATG5chr6

106763976

-SYNJ2chr6

158502141

+
intron-3CDSENST00000475645ENST00000367122ATG5chr6

106763976

-SYNJ2chr6

158502141

+
intron-5UTRENST00000475645ENST00000367112ATG5chr6

106763976

-SYNJ2chr6

158502141

+
intron-intronENST00000475645ENST00000449859ATG5chr6

106763976

-SYNJ2chr6

158502141

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000369076ATG5chr6106763976-ENST00000367121SYNJ2chr6158502141+17324324061731442
ENST00000369076ATG5chr6106763976-ENST00000367122SYNJ2chr6158502141+50304324062220604
ENST00000369076ATG5chr6106763976-ENST00000355585SYNJ2chr6158502141+51684324062355649

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369076ENST00000367121ATG5chr6106763976-SYNJ2chr6158502141+0.008723590.9912764
ENST00000369076ENST00000367122ATG5chr6106763976-SYNJ2chr6158502141+0.000413520.9995865
ENST00000369076ENST00000355585ATG5chr6106763976-SYNJ2chr6158502141+0.0008022250.9991978

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Fusion Genomic Features for ATG5-SYNJ2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATG5chr6106763975-SYNJ2chr6158502140+6.02E-121
ATG5chr6106763975-SYNJ2chr6158502140+6.02E-121
ATG5chr6106763975-SYNJ2chr6158502140+6.02E-121
ATG5chr6106763975-SYNJ2chr6158502140+6.02E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ATG5-SYNJ2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:106763976/chr6:158502141)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATG5

Q9H1Y0

.
FUNCTION: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. {ECO:0000250|UniProtKB:Q99J83, ECO:0000269|PubMed:12207896, ECO:0000269|PubMed:20580051, ECO:0000269|PubMed:22170153, ECO:0000269|PubMed:26812546}.; FUNCTION: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD. {ECO:0000269|PubMed:15778222, ECO:0000269|PubMed:7796880}.; FUNCTION: (Microbial infection) May act as a proviral factor. In association with ATG12, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection (PubMed:17709747). Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for initiation of HCV replication, but not required once infection is established (PubMed:19666601). {ECO:0000269|PubMed:17709747, ECO:0000269|PubMed:19666601}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSYNJ2chr6:106763976chr6:158502141ENST0000035558517271099_11148551497.0Compositional biasNote=Pro-rich
TgeneSYNJ2chr6:106763976chr6:158502141ENST0000035558517271209_13348551497.0Compositional biasNote=Pro-rich
TgeneSYNJ2chr6:106763976chr6:158502141ENST0000036712117271099_11148551289.0Compositional biasNote=Pro-rich
TgeneSYNJ2chr6:106763976chr6:158502141ENST0000036712117271209_13348551289.0Compositional biasNote=Pro-rich
TgeneSYNJ2chr6:106763976chr6:158502141ENST000003555851727889_9688551497.0DomainRRM
TgeneSYNJ2chr6:106763976chr6:158502141ENST000003671211727889_9688551289.0DomainRRM

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSYNJ2chr6:106763976chr6:158502141ENST000003555851727120_4448551497.0DomainSAC
TgeneSYNJ2chr6:106763976chr6:158502141ENST000003671211727120_4448551289.0DomainSAC


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Fusion Gene Sequence for ATG5-SYNJ2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7605_7605_1_ATG5-SYNJ2_ATG5_chr6_106763976_ENST00000369076_SYNJ2_chr6_158502141_ENST00000355585_length(transcript)=5168nt_BP=432nt
CTGGACTTGTGGTGCGCTGCCAGGGCTCCGCAGCGTTGCCGGTTGTATTCGCTGGATACCAGAGGGCGGAAGTGCAGCAGGGTTCAGCTC
CGACCTCCGCGCCGGTGCTTTTTGCGGCTGCGCGGGCTTCCTGGAGTCCTGCTACCGCGTCCCCGCAGGACAGTGTGTCAGGCGGGCAGC
TTGCCCCGCCGCCCCACCGGAGCGCGGAATCTGGGCGTCCCCACCAGTGCGGGGAGCCGGAAGGAGGAGCCATAGCTTGGAGTAGGTTTG
GCTTTGGTTGAAATAAGAATTTAGCCTGTATGTACTGCTTTAACTCCTGGAAGAATGACAGATGACAAAGATGTGCTTCGAGATGTGTGG
TTTGGACGAATTCCAACTTGTTTCACGCTATATCAGGATGAGATAACTGAAAGGGAAGCAGAACCATACTATACCTGTGCTGGCGATCGT
GGAGGTGGAAGTTCAGGAAGTCGATGTGGGTGCTCGGGAGAGGGTTTTCCAGGAAGTGTCCTCCTTCCAGGGCCCCCTGGATGCCACTGT
TGTAGTAAACCTTCAATCACCGACCTTAGAAGAGAAAAACGAGTTTCCAGAGGACCTGCGTACTGAGCTCATGCAGACCTTGGGGAGTTA
TGGGACAATTGTTCTTGTCAGGATCAACCAAGGGCAGATGCTGGTAACTTTTGCAGACAGTCACTCGGCTCTCAGTGTCCTGGACGTGGA
CGGTATGAAGGTGAAAGGCAGAGCAGTGAAGATTAGACCGAAGACCAAGGACTGGCTGAAAGGTTTGCGAGAGGAGATCATTCGGAAACG
AGACAGCATGGCCCCCGTGTCTCCCACTGCCAACTCCTGTTTGCTGGAGGAAAACTTTGACTTCACAAGTTTGGACTATGAGTCAGAAGG
GGATATTCTTGAAGACGATGAAGACTACTTGGTGGATGAATTCAATCAGCCTGGAGTCTCGGACAGTGAACTCGGGGGAGACGACCTCTC
TGATGTCCCCGGCCCCACAGCACTGGCTCCTCCCAGCAAGTCACCTGCTCTCACCAAAAAGAAGCAGCATCCAACGTACAAAGATGACGC
GGACCTGGTGGAGCTCAAGCGGGAGCTGGAAGCCGTCGGGGAGTTCCGCCACCGTTCTCCGAGCAGGTCTCTGTCGGTCCCCAACCGGCC
TCGGCCACCTCAACCCCCGCAGAGACCCCCCCCTCCAACCGGTTTAATGGTGAAAAAGTCGGCTTCAGATGCGTCCATCTCCTCCGGCAC
CCATGGACAGTATTCAATTTTGCAGACGGCAAGACTTCTACCAGGAGCACCTCAGCAACCTCCCAAGGCTCGGACTGGAATAAGTAAACC
TTATAATGTCAAGCAGATCAAAACCACCAATGCCCAGGAGGCAGAAGCAGCAATCCGGTGTCTCCTGGAAGCCAGAGGAGGTGCCTCCGA
AGAAGCCCTAAGTGCCGTGGCCCCAAGGGACCTTGAAGCATCCTCTGAACCAGAGCCCACACCGGGGGCAGCCAAACCAGAGACCCCACA
GGCGCCCCCACTCCTTCCCCGTCGGCCCCCACCCAGAGTTCCTGCCATCAAGAAGCCAACCTTGAGAAGGACAGGAAAGCCCCTGTCACC
GGAAGAACAGTTTGAGCAACAGACTGTCCATTTTACAATCGGGCCCCCGGAGACAAGCGTTGAGGCCCCTCCTGTCGTGACAGCCCCTCG
AGTCCCTCCTGTTCCCAAACCAAGAACATTTCAGCCTGGGAAAGCTGCAGAGAGGCCAAGCCACAGGAAGCCAGCATCAGACGAAGCCCC
TCCTGGGGCAGGAGCCTCTGTGCCACCACCTCTGGAGGCGCCGCCTCTTGTGCCCAAGGTACCCCCGAGGAGGAAGAAGTCAGCCCCCGC
AGCCTTCCACCTGCAGGTCCTGCAGAGCAACAGCCAGCTTCTCCAGGGCCTCACTTACAATAGCAGTGACAGCCCCTCTGGGCACCCACC
TGCCGCGGGCACCGTCTTCCCACAAGGGGACTTTCTCAGCACTTCATCTGCTACAAGCCCCGACAGCGATGGCACCAAAGCGATGAAGCC
AGAGGCAGCCCCACTTCTTGGTGATTATCAGGACCCCTTCTGGAACCTTCTTCACCACCCTAAACTGTTGAATAACACTTGGCTTTCTAA
GAGCTCAGACCCTTTGGACTCAGGAACCAGGAGCCCCAAAAGAGATCCCATAGACCCAGTGTCAGCTGGCGCTTCAGCTGCCAAGGCAGA
GCTGCCACCAGATCATGAACACAAAACCTTAGGTCACTGGGTGACAATCAGTGACCAAGAAAAGAGGACAGCACTGCAGGTGTTTGACCC
ACTGGCAAAAACATGACTGAGCAGCTTTGAAGGCTGCAGTCCTATAGAATGCATACCTTCCTCCCTCTAGACATCCCTCCACCAGAAGAG
ACATCTATTTAAAGGCACACTGGCCAAAACGTTTGTGCATCTGTCACTCTCGTGTAGTTTACAAAAATCGTGTCTCTTATTCAGTAAGAT
GGTTACTCAGCCACCAAAATATATTTCACTCAAGGCTTGTACATCTGAAGTTTGCTCTTCAAGGAATGGGAACCTTCCTGTTAAATTCGG
TGTATGGATTTTAAGAAAGGAATCTAGCCAATGAGGTCCAAGAAGTTCTCACCCATTGAATTTTTAAATGGCTGTTCAGTTCATGTTGTA
CGTGATGGAGATTTGTCTTTTGTTTTATTTGCATTTTACAGATTTGGTATAACATTTTGGGGAGCCACCTGAAGGTTGATGTATAAAGTA
AGGATTAGAGAAAGAGGTCGTTGTGACCATTAGTAGCTGTCCTGGCCCACTTAAACAAGGTTACAAAAAATCAGAGTCGGAAGCAGCCAA
ATAGGTCAACCTAATGACTAGACTGTACATTCCCATGAGCCTTCATGTTTAAGTGTGTACATGTGCGTTAACCTTGATGATGCGTGAATC
CCGAGGGAGCCGGTGGCATACACCGTTAGCTTAACCTTAGCTTAAACTAGCTGAAGGCTCCTGTGCCATGTCTTAGACATTGCATGCCCT
ATCAATTACTATAATCCTGAGCCATGGTGTGCTACTGAAACCAATTTTTATCCACCATCTAGTCCTTATTAAATGAAACCTCACGGATCC
TTTGTTCCGCTTATATTCCATGCATACCACATAAAAGCACACAGTGCGAAAACTCTTGCTGATACGCGATATTGATTCTCATTGTTAGAA
TATGGAGAGTGTTTCAGCCTCGTCTGTCCGGCTGGAGCTTCGGGATGGAAAGTGCTATGTGTCCCTGCATATAAGAATCACCAGGCCAGT
GTTTCTGGGTTTGCTTGTCTATATGTTTGTCTATATTTTTTGCCTATACATTTTTCCCACGTTTCCAACAGCACTTCTCACCTATTCAAT
AACTGAAAAAGACATTACCATAGTGCTTTACATTTTTAAAGTAATGTTACAAGGTCTGGAATCCATTTGGAGCAGATACCGTGTTTTCGC
TATTTAATAAGAAGTTCAGTAGTGAAATCTTACTGTACCGCCTGTTGTATCTGGGAGCCTCGTACAGAGGCTCGCACAGCAGTGATCAAG
TGTCATCCCTTACGTGACTGGGGGATGTCTGTCCTAAAAGCTGACTGCTAGGATAGTAAGGATCATCTTGCCTGGGCTATGCCACTGTCT
TGTTACCAATTAGACATCTGGAATTTCATAATTAGTTTTCATTGTCACTGTCAAGATATATTGCAGATTACTTAAATATGGCCATCAAAA
CAAAAGTTACAACACGTATCTCTTTTCATCTGAAAACTAATACCTGGAAAAGGATAAAAAAAAAAAGGAATCCGTGACCCACAGAGCTAG
ACAGATAAGATGCATAGTTGACCAGTCATAAAAGGCGGTGTTTAGGTGATCAGGATGCCGTTGGTGGCATTTACGTGCTTTATATGATTT
TTACCTCTGTAACAAACACAAGAAATAAACAGAATGGTCCTTAACAGAGTTTGGGGGAGAGAGCAAGATGGGTTCCTTGGAGAAGCTGAT
TTGCCAAGATGCACATCGCTATTAACAGCCAGAGTCATAAATGAAATGAAATTGAAGAATTCATTCAAATGCTCTTTTCCCTATAACCTC
TTTTCTCACCAAAAAGGAGATAAATTTGAAAACAGATAAATGTAACAACCAGTCAAAGAAGCAGGGGAAAAGTAAGCTCCTCCAAAGTTG
CTTGCAGTGCTGGAAATAGATCTCATTTTTAGGTTTTCTCTTCGTTCCAGATACCAAATAAATGGGACAGAGAATAAAATTTTTGTTAAA
ATATGTGCTCATCTCCTAAGTAGCTCTTCAGAGTCTGACCGTAAGTAAAAACACACAGAATTGTGTTGACTGGGGGAGGTGAATCACAAA
AAAGTTACGAGGAGTTTAAGAGTTAAATATTATTTGATCGTGGCTGTCAAATTTAGTGAACAACATAGATTGGATTTGGAGTTGGTAGTA
GGTATGGTTCTCATACCAGAATTCTCTTAAAAAAAAAAAAAAGGACAATTGGAATTGCCTTATTTATTTTTAAAATCAATGCTTACTAGT
TGGTAGGATTCCCAGGTCAGCAGCAGGGTTGATTAAATAATCTTGACAATGAGCAGCTGCCATCTTGGGGGATTTCATTCTGTGGTTTTT
TAAATGTTTCGTCTTTGATGCTACCATCCAGGGCTTCTTATTGTGACCTTGTAGCCTATTTTGTTCCTGCTGTTCTCTAACATGGTGCAG
TTCACGCAGACTGGTTTAGGTACTTCACAACTCACCATTGTCTCTCTGACCCCAAGCCTAGTCCCTTTTACATCACCATCTTCTCAGACT
TCTTGCCTATTCTTAAAATATGTTTTGGTTAATGATTGAATTAGGACATCAGCTTAAGCAATTCCTGTAACGGTTTAACGTTGTTGAAGT
TCAAGGCACATAATAAAATTCTCCCTGATGTGTGTGTAAGTATAAACAAAGTAATGTATCAAAGCGTTCACTTTATAATGAAGTCATTTC
ATTGGGAAGGAAAGCTGCAAAGATTATTGGGGGACTAGTGATTAATAAAATCCTGTAATATTTTTGAAGTGAAAATTTGTACTGAAATTG

>7605_7605_1_ATG5-SYNJ2_ATG5_chr6_106763976_ENST00000369076_SYNJ2_chr6_158502141_ENST00000355585_length(amino acids)=649AA_BP=9
MKGKQNHTIPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLV
TFADSHSALSVLDVDGMKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDEDYLVDEFN
QPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGL
MVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASS
EPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKA
AERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTS
SATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSGTRSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVT

--------------------------------------------------------------
>7605_7605_2_ATG5-SYNJ2_ATG5_chr6_106763976_ENST00000369076_SYNJ2_chr6_158502141_ENST00000367121_length(transcript)=1732nt_BP=432nt
CTGGACTTGTGGTGCGCTGCCAGGGCTCCGCAGCGTTGCCGGTTGTATTCGCTGGATACCAGAGGGCGGAAGTGCAGCAGGGTTCAGCTC
CGACCTCCGCGCCGGTGCTTTTTGCGGCTGCGCGGGCTTCCTGGAGTCCTGCTACCGCGTCCCCGCAGGACAGTGTGTCAGGCGGGCAGC
TTGCCCCGCCGCCCCACCGGAGCGCGGAATCTGGGCGTCCCCACCAGTGCGGGGAGCCGGAAGGAGGAGCCATAGCTTGGAGTAGGTTTG
GCTTTGGTTGAAATAAGAATTTAGCCTGTATGTACTGCTTTAACTCCTGGAAGAATGACAGATGACAAAGATGTGCTTCGAGATGTGTGG
TTTGGACGAATTCCAACTTGTTTCACGCTATATCAGGATGAGATAACTGAAAGGGAAGCAGAACCATACTATACCTGTGCTGGCGATCGT
GGAGGTGGAAGTTCAGGAAGTCGATGTGGGTGCTCGGGAGAGGGTTTTCCAGGAAGTGTCCTCCTTCCAGGGCCCCCTGGATGCCACTGT
TGTAGTAAACCTTCAATCACCGACCTTAGAAGAGAAAAACGAGTTTCCAGAGGACCTGCGTACTGAGCTCATGCAGACCTTGGGGAGTTA
TGGGACAATTGTTCTTGTCAGGATCAACCAAGGGCAGATGCTGGTAACTTTTGCAGACAGTCACTCGGCTCTCAGTGTCCTGGACGTGGA
CGGTATGAAGGTGAAAGGCAGAGCAGTGAAGATTAGACCGAAGACCAAGGACTGGCTGAAAGGTTTGCGAGAGGAGATCATTCGGAAACG
AGACAGCATGGCCCCCGTGTCTCCCACTGCCAACTCCTGTTTGCTGGAGGAAAACTTTGACTTCACAAGTTTGGACTATGAGTCAGAAGG
GGATATTCTTGAAGACGATGAAGACTACTTGGTGGATGAATTCAATCAGCCTGGAGTCTCGGACAGTGAACTCGGGGGAGACGACCTCTC
TGATGTCCCCGGCCCCACAGCACTGGCTCCTCCCAGCAAGTCACCTGCTCTCACCAAAAAGAAGCAGCATCCAACGTACAAAGATGACGC
GGACCTGGTGGAGCTCAAGCGGGAGCTGGAAGCCGTCGGGGAGTTCCGCCACCGTTCTCCGAGCAGGTCTCTGTCGGTCCCCAACCGGCC
TCGGCCACCTCAACCCCCGCAGAGACCCCCCCCTCCAACCGGTTTAATGGTGAAAAAGTCGGCTTCAGATGCGTCCATCTCCTCCGGCAC
CCATGGACAGTATTCAATTTTGCAGACGGCAAGACTTCTACCAGGAGCACCTCAGCAACCTCCCAAGGCTCGGACTGGAATAAGTAAACC
TTATAATGTCAAGCAGATCAAAACCACCAATGCCCAGGAGGCAGAAGCAGCAATCCGGTGTCTCCTGGAAGCCAGAGGAGGTGCCTCCGA
AGAAGCCCTAAGTGCCGTGGCCCCAAGGGACCTTGAAGCATCCTCTGAACCAGAGCCCACACCGGGGGCAGCCAAACCAGAGACCCCACA
GGCGCCCCCACTCCTTCCCCGTCGGCCCCCACCCAGAGTTCCTGCCATCAAGAAGCCAACCTTGAGAAGGACAGGAAAGATTGTTTTTTG
CTCTCGCTCTCAAGCTTCTCAGCCTTGCTTACTGCTTCAAAGACATGAGTTTGTAAGGACAGTAGCAGCCCAAAGACTGGCATCTGTAGA

>7605_7605_2_ATG5-SYNJ2_ATG5_chr6_106763976_ENST00000369076_SYNJ2_chr6_158502141_ENST00000367121_length(amino acids)=442AA_BP=9
MKGKQNHTIPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLV
TFADSHSALSVLDVDGMKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDEDYLVDEFN
QPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGL
MVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASS

--------------------------------------------------------------
>7605_7605_3_ATG5-SYNJ2_ATG5_chr6_106763976_ENST00000369076_SYNJ2_chr6_158502141_ENST00000367122_length(transcript)=5030nt_BP=432nt
CTGGACTTGTGGTGCGCTGCCAGGGCTCCGCAGCGTTGCCGGTTGTATTCGCTGGATACCAGAGGGCGGAAGTGCAGCAGGGTTCAGCTC
CGACCTCCGCGCCGGTGCTTTTTGCGGCTGCGCGGGCTTCCTGGAGTCCTGCTACCGCGTCCCCGCAGGACAGTGTGTCAGGCGGGCAGC
TTGCCCCGCCGCCCCACCGGAGCGCGGAATCTGGGCGTCCCCACCAGTGCGGGGAGCCGGAAGGAGGAGCCATAGCTTGGAGTAGGTTTG
GCTTTGGTTGAAATAAGAATTTAGCCTGTATGTACTGCTTTAACTCCTGGAAGAATGACAGATGACAAAGATGTGCTTCGAGATGTGTGG
TTTGGACGAATTCCAACTTGTTTCACGCTATATCAGGATGAGATAACTGAAAGGGAAGCAGAACCATACTATACCTGTGCTGGCGATCGT
GGAGGTGGAAGTTCAGGAAGTCGATGTGGGTGCTCGGGAGAGGGTTTTCCAGGAAGTGTCCTCCTTCCAGGGCCCCCTGGATGCCACTGT
TGTAGTAAACCTTCAATCACCGACCTTAGAAGAGAAAAACGAGTTTCCAGAGGACCTGCGTACTGAGCTCATGCAGACCTTGGGGAGTTA
TGGGACAATTGTTCTTGTCAGGATCAACCAAGGGCAGATGCTGGTAACTTTTGCAGACAGTCACTCGGCTCTCAGTGTCCTGGACGTGGA
CGGTATGAAGGTGAAAGGCAGAGCAGTGAAGATTAGACCGAAGACCAAGGACTGGCTGAAAGGTTTGCGAGAGGAGATCATTCGGAAACG
AGACAGCATGGCCCCCGTGTCTCCCACTGCCAACTCCTGTTTGCTGGAGGAAAACTTTGACTTCACAAGTTTGGACTATGAGTCAGAAGG
GGATATTCTTGAAGACGATGAAGACTACTTGGTGGATGAATTCAATCAGCCTGGAGTCTCGGACAGTGAACTCGGGGGAGACGACCTCTC
TGATGTCCCCGGCCCCACAGCACTGGCTCCTCCCAGCAAGTCACCTGCTCTCACCAAAAAGAAGCAGCATCCAACGTACAAAGCCGGTTT
AATGGTGAAAAAGTCGGCTTCAGATGCGTCCATCTCCTCCGGCACCCATGGACAGTATTCAATTTTGCAGACGGCAAGACTTCTACCAGG
AGCACCTCAGCAACCTCCCAAGGCTCGGACTGGAATAAGTAAACCTTATAATGTCAAGCAGATCAAAACCACCAATGCCCAGGAGGCAGA
AGCAGCAATCCGGTGTCTCCTGGAAGCCAGAGGAGGTGCCTCCGAAGAAGCCCTAAGTGCCGTGGCCCCAAGGGACCTTGAAGCATCCTC
TGAACCAGAGCCCACACCGGGGGCAGCCAAACCAGAGACCCCACAGGCGCCCCCACTCCTTCCCCGTCGGCCCCCACCCAGAGTTCCTGC
CATCAAGAAGCCAACCTTGAGAAGGACAGGAAAGCCCCTGTCACCGGAAGAACAGTTTGAGCAACAGACTGTCCATTTTACAATCGGGCC
CCCGGAGACAAGCGTTGAGGCCCCTCCTGTCGTGACAGCCCCTCGAGTCCCTCCTGTTCCCAAACCAAGAACATTTCAGCCTGGGAAAGC
TGCAGAGAGGCCAAGCCACAGGAAGCCAGCATCAGACGAAGCCCCTCCTGGGGCAGGAGCCTCTGTGCCACCACCTCTGGAGGCGCCGCC
TCTTGTGCCCAAGGTACCCCCGAGGAGGAAGAAGTCAGCCCCCGCAGCCTTCCACCTGCAGGTCCTGCAGAGCAACAGCCAGCTTCTCCA
GGGCCTCACTTACAATAGCAGTGACAGCCCCTCTGGGCACCCACCTGCCGCGGGCACCGTCTTCCCACAAGGGGACTTTCTCAGCACTTC
ATCTGCTACAAGCCCCGACAGCGATGGCACCAAAGCGATGAAGCCAGAGGCAGCCCCACTTCTTGGTGATTATCAGGACCCCTTCTGGAA
CCTTCTTCACCACCCTAAACTGTTGAATAACACTTGGCTTTCTAAGAGCTCAGACCCTTTGGACTCAGGAACCAGGAGCCCCAAAAGAGA
TCCCATAGACCCAGTGTCAGCTGGCGCTTCAGCTGCCAAGGCAGAGCTGCCACCAGATCATGAACACAAAACCTTAGGTCACTGGGTGAC
AATCAGTGACCAAGAAAAGAGGACAGCACTGCAGGTGTTTGACCCACTGGCAAAAACATGACTGAGCAGCTTTGAAGGCTGCAGTCCTAT
AGAATGCATACCTTCCTCCCTCTAGACATCCCTCCACCAGAAGAGACATCTATTTAAAGGCACACTGGCCAAAACGTTTGTGCATCTGTC
ACTCTCGTGTAGTTTACAAAAATCGTGTCTCTTATTCAGTAAGATGGTTACTCAGCCACCAAAATATATTTCACTCAAGGCTTGTACATC
TGAAGTTTGCTCTTCAAGGAATGGGAACCTTCCTGTTAAATTCGGTGTATGGATTTTAAGAAAGGAATCTAGCCAATGAGGTCCAAGAAG
TTCTCACCCATTGAATTTTTAAATGGCTGTTCAGTTCATGTTGTACGTGATGGAGATTTGTCTTTTGTTTTATTTGCATTTTACAGATTT
GGTATAACATTTTGGGGAGCCACCTGAAGGTTGATGTATAAAGTAAGGATTAGAGAAAGAGGTCGTTGTGACCATTAGTAGCTGTCCTGG
CCCACTTAAACAAGGTTACAAAAAATCAGAGTCGGAAGCAGCCAAATAGGTCAACCTAATGACTAGACTGTACATTCCCATGAGCCTTCA
TGTTTAAGTGTGTACATGTGCGTTAACCTTGATGATGCGTGAATCCCGAGGGAGCCGGTGGCATACACCGTTAGCTTAACCTTAGCTTAA
ACTAGCTGAAGGCTCCTGTGCCATGTCTTAGACATTGCATGCCCTATCAATTACTATAATCCTGAGCCATGGTGTGCTACTGAAACCAAT
TTTTATCCACCATCTAGTCCTTATTAAATGAAACCTCACGGATCCTTTGTTCCGCTTATATTCCATGCATACCACATAAAAGCACACAGT
GCGAAAACTCTTGCTGATACGCGATATTGATTCTCATTGTTAGAATATGGAGAGTGTTTCAGCCTCGTCTGTCCGGCTGGAGCTTCGGGA
TGGAAAGTGCTATGTGTCCCTGCATATAAGAATCACCAGGCCAGTGTTTCTGGGTTTGCTTGTCTATATGTTTGTCTATATTTTTTGCCT
ATACATTTTTCCCACGTTTCCAACAGCACTTCTCACCTATTCAATAACTGAAAAAGACATTACCATAGTGCTTTACATTTTTAAAGTAAT
GTTACAAGGTCTGGAATCCATTTGGAGCAGATACCGTGTTTTCGCTATTTAATAAGAAGTTCAGTAGTGAAATCTTACTGTACCGCCTGT
TGTATCTGGGAGCCTCGTACAGAGGCTCGCACAGCAGTGATCAAGTGTCATCCCTTACGTGACTGGGGGATGTCTGTCCTAAAAGCTGAC
TGCTAGGATAGTAAGGATCATCTTGCCTGGGCTATGCCACTGTCTTGTTACCAATTAGACATCTGGAATTTCATAATTAGTTTTCATTGT
CACTGTCAAGATATATTGCAGATTACTTAAATATGGCCATCAAAACAAAAGTTACAACACGTATCTCTTTTCATCTGAAAACTAATACCT
GGAAAAGGATAAAAAAAAAAAGGAATCCGTGACCCACAGAGCTAGACAGATAAGATGCATAGTTGACCAGTCATAAAAGGCGGTGTTTAG
GTGATCAGGATGCCGTTGGTGGCATTTACGTGCTTTATATGATTTTTACCTCTGTAACAAACACAAGAAATAAACAGAATGGTCCTTAAC
AGAGTTTGGGGGAGAGAGCAAGATGGGTTCCTTGGAGAAGCTGATTTGCCAAGATGCACATCGCTATTAACAGCCAGAGTCATAAATGAA
ATGAAATTGAAGAATTCATTCAAATGCTCTTTTCCCTATAACCTCTTTTCTCACCAAAAAGGAGATAAATTTGAAAACAGATAAATGTAA
CAACCAGTCAAAGAAGCAGGGGAAAAGTAAGCTCCTCCAAAGTTGCTTGCAGTGCTGGAAATAGATCTCATTTTTAGGTTTTCTCTTCGT
TCCAGATACCAAATAAATGGGACAGAGAATAAAATTTTTGTTAAAATATGTGCTCATCTCCTAAGTAGCTCTTCAGAGTCTGACCGTAAG
TAAAAACACACAGAATTGTGTTGACTGGGGGAGGTGAATCACAAAAAAGTTACGAGGAGTTTAAGAGTTAAATATTATTTGATCGTGGCT
GTCAAATTTAGTGAACAACATAGATTGGATTTGGAGTTGGTAGTAGGTATGGTTCTCATACCAGAATTCTCTTAAAAAAAAAAAAAAGGA
CAATTGGAATTGCCTTATTTATTTTTAAAATCAATGCTTACTAGTTGGTAGGATTCCCAGGTCAGCAGCAGGGTTGATTAAATAATCTTG
ACAATGAGCAGCTGCCATCTTGGGGGATTTCATTCTGTGGTTTTTTAAATGTTTCGTCTTTGATGCTACCATCCAGGGCTTCTTATTGTG
ACCTTGTAGCCTATTTTGTTCCTGCTGTTCTCTAACATGGTGCAGTTCACGCAGACTGGTTTAGGTACTTCACAACTCACCATTGTCTCT
CTGACCCCAAGCCTAGTCCCTTTTACATCACCATCTTCTCAGACTTCTTGCCTATTCTTAAAATATGTTTTGGTTAATGATTGAATTAGG
ACATCAGCTTAAGCAATTCCTGTAACGGTTTAACGTTGTTGAAGTTCAAGGCACATAATAAAATTCTCCCTGATGTGTGTGTAAGTATAA
ACAAAGTAATGTATCAAAGCGTTCACTTTATAATGAAGTCATTTCATTGGGAAGGAAAGCTGCAAAGATTATTGGGGGACTAGTGATTAA

>7605_7605_3_ATG5-SYNJ2_ATG5_chr6_106763976_ENST00000369076_SYNJ2_chr6_158502141_ENST00000367122_length(amino acids)=604AA_BP=9
MKGKQNHTIPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLV
TFADSHSALSVLDVDGMKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDEDYLVDEFN
QPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKAGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKP
YNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSP
EEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAPA
AFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ATG5-SYNJ2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATG5-SYNJ2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATG5-SYNJ2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource