FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:RPL18-RPS2 (FusionGDB2 ID:76067)

Fusion Gene Summary for RPL18-RPS2

check button Fusion gene summary
Fusion gene informationFusion gene name: RPL18-RPS2
Fusion gene ID: 76067
HgeneTgene
Gene symbol

RPL18

RPS2

Gene ID

6141

6187

Gene nameribosomal protein L18ribosomal protein S2
SynonymsDBA18|L18LLREP3|S2
Cytomap

19q13.33

16p13.3

Type of geneprotein-codingprotein-coding
Description60S ribosomal protein L18large ribosomal subunit protein eL1840S ribosomal protein S240S ribosomal protein S4OK/KNS-cl.6protein LLRep3small ribosomal subunit protein uS5
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000549273, ENST00000549920, 
ENST00000550645, ENST00000552588, 
ENST00000343262, ENST00000526522, 
ENST00000529806, ENST00000530225, 
Fusion gene scores* DoF score39 X 18 X 9=631810 X 8 X 4=320
# samples 3911
** MAII scorelog2(39/6318*10)=-4.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/320*10)=-1.5405683813627
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPL18 [Title/Abstract] AND RPS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRPL18(49122397)-RPS2(2013257), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPL18

GO:0002181

cytoplasmic translation

25957688

TgeneRPS2

GO:0051443

positive regulation of ubiquitin-protein transferase activity

18573314


check buttonFusion gene breakpoints across RPL18 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RPS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-DM-A1D8RPL18chr19

49122397

-RPS2chr16

2013257

-


Top

Fusion Gene ORF analysis for RPL18-RPS2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000549273ENST00000343262RPL18chr19

49122397

-RPS2chr16

2013257

-
In-frameENST00000549273ENST00000526522RPL18chr19

49122397

-RPS2chr16

2013257

-
In-frameENST00000549273ENST00000529806RPL18chr19

49122397

-RPS2chr16

2013257

-
In-frameENST00000549273ENST00000530225RPL18chr19

49122397

-RPS2chr16

2013257

-
In-frameENST00000549920ENST00000343262RPL18chr19

49122397

-RPS2chr16

2013257

-
In-frameENST00000549920ENST00000526522RPL18chr19

49122397

-RPS2chr16

2013257

-
In-frameENST00000549920ENST00000529806RPL18chr19

49122397

-RPS2chr16

2013257

-
In-frameENST00000549920ENST00000530225RPL18chr19

49122397

-RPS2chr16

2013257

-
In-frameENST00000550645ENST00000343262RPL18chr19

49122397

-RPS2chr16

2013257

-
In-frameENST00000550645ENST00000526522RPL18chr19

49122397

-RPS2chr16

2013257

-
In-frameENST00000550645ENST00000529806RPL18chr19

49122397

-RPS2chr16

2013257

-
In-frameENST00000550645ENST00000530225RPL18chr19

49122397

-RPS2chr16

2013257

-
In-frameENST00000552588ENST00000343262RPL18chr19

49122397

-RPS2chr16

2013257

-
In-frameENST00000552588ENST00000526522RPL18chr19

49122397

-RPS2chr16

2013257

-
In-frameENST00000552588ENST00000529806RPL18chr19

49122397

-RPS2chr16

2013257

-
In-frameENST00000552588ENST00000530225RPL18chr19

49122397

-RPS2chr16

2013257

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000549920RPL18chr1949122397-ENST00000343262RPS2chr162013257-10573961831010275
ENST00000549920RPL18chr1949122397-ENST00000526522RPS2chr162013257-875396183836217
ENST00000549920RPL18chr1949122397-ENST00000530225RPS2chr162013257-888396183722179
ENST00000549920RPL18chr1949122397-ENST00000529806RPS2chr162013257-1025396183848221
ENST00000550645RPL18chr1949122397-ENST00000343262RPS2chr162013257-6842320637205
ENST00000550645RPL18chr1949122397-ENST00000526522RPS2chr162013257-5022320463147
ENST00000550645RPL18chr1949122397-ENST00000530225RPS2chr162013257-5152320349109
ENST00000550645RPL18chr1949122397-ENST00000529806RPS2chr162013257-6522320475151
ENST00000552588RPL18chr1949122397-ENST00000343262RPS2chr162013257-7024138655205
ENST00000552588RPL18chr1949122397-ENST00000526522RPS2chr162013257-5204138481147
ENST00000552588RPL18chr1949122397-ENST00000530225RPS2chr162013257-5334138367109
ENST00000552588RPL18chr1949122397-ENST00000529806RPS2chr162013257-6704138493151
ENST00000549273RPL18chr1949122397-ENST00000343262RPS2chr162013257-6983734651205
ENST00000549273RPL18chr1949122397-ENST00000526522RPS2chr162013257-5163734477147
ENST00000549273RPL18chr1949122397-ENST00000530225RPS2chr162013257-5293734363109
ENST00000549273RPL18chr1949122397-ENST00000529806RPS2chr162013257-6663734489151

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000549920ENST00000343262RPL18chr1949122397-RPS2chr162013257-0.0031838030.9968162
ENST00000549920ENST00000526522RPL18chr1949122397-RPS2chr162013257-0.0118516080.9881484
ENST00000549920ENST00000530225RPL18chr1949122397-RPS2chr162013257-0.0155598110.9844402
ENST00000549920ENST00000529806RPL18chr1949122397-RPS2chr162013257-0.0049652640.9950347
ENST00000550645ENST00000343262RPL18chr1949122397-RPS2chr162013257-0.0030550840.99694496
ENST00000550645ENST00000526522RPL18chr1949122397-RPS2chr162013257-0.0209644380.9790356
ENST00000550645ENST00000530225RPL18chr1949122397-RPS2chr162013257-0.0172735150.98272645
ENST00000550645ENST00000529806RPL18chr1949122397-RPS2chr162013257-0.0031908050.9968092
ENST00000552588ENST00000343262RPL18chr1949122397-RPS2chr162013257-0.003414620.99658537
ENST00000552588ENST00000526522RPL18chr1949122397-RPS2chr162013257-0.0242968560.9757032
ENST00000552588ENST00000530225RPL18chr1949122397-RPS2chr162013257-0.0149651540.9850348
ENST00000552588ENST00000529806RPL18chr1949122397-RPS2chr162013257-0.0036280890.996372
ENST00000549273ENST00000343262RPL18chr1949122397-RPS2chr162013257-0.0033677830.9966323
ENST00000549273ENST00000526522RPL18chr1949122397-RPS2chr162013257-0.0247175670.97528243
ENST00000549273ENST00000530225RPL18chr1949122397-RPS2chr162013257-0.0153777350.9846223
ENST00000549273ENST00000529806RPL18chr1949122397-RPS2chr162013257-0.00364580.9963542

Top

Fusion Genomic Features for RPL18-RPS2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for RPL18-RPS2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:49122397/chr16:2013257)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRPS2chr19:49122397chr16:2013257ENST0000034326227102_16589294.0DomainS5 DRBM

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRPS2chr19:49122397chr16:2013257ENST000003432622722_5389294.0Compositional biasNote=Arg/Gly-rich


Top

Fusion Gene Sequence for RPL18-RPS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>76067_76067_1_RPL18-RPS2_RPL18_chr19_49122397_ENST00000549273_RPS2_chr16_2013257_ENST00000343262_length(transcript)=698nt_BP=37nt
TCTTTCCGGACCTGGCCGAGCAGGAGGCGCCATCATGGAATCAGAGATCATTGATTTCTTCCTGGGGGCCTCTCTCAAGGATGAGGTTTT
GAAGATTATGCCAGTGCAGAAGCAGACCCGTGCCGGCCAGCGCACCAGGTTCAAGGCATTTGTTGCTATCGGGGACTACAATGGCCACGT
CGGTCTGGGTGTTAAGTGCTCCAAGGAGGTGGCCACCGCCATCCGTGGGGCCATCATCCTGGCCAAGCTCTCCATCGTCCCCGTGCGCAG
AGGCTACTGGGGGAACAAGATCGGCAAGCCCCACACTGTCCCTTGCAAGGTGACAGGCCGCTGCGGCTCTGTGCTGGTACGCCTCATCCC
TGCACCCAGGGGCACTGGCATCGTCTCCGCACCTGTGCCTAAGAAGCTGCTCATGATGGCTGGTATCGATGACTGCTACACCTCAGCCCG
GGGCTGCACTGCCACCCTGGGCAACTTCGCCAAGGCCACCTTTGATGCCATTTCTAAGACCTACAGCTACCTGACCCCCGACCTCTGGAA
GGAGACTGTATTCACCAAGTCTCCCTATCAGGAGTTCACTGACCACCTCGTCAAGACCCACACCAGAGTCTCCGTGCAGCGGACTCAGGC

>76067_76067_1_RPL18-RPS2_RPL18_chr19_49122397_ENST00000549273_RPS2_chr16_2013257_ENST00000343262_length(amino acids)=205AA_BP=1
MESEIIDFFLGASLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPH
TVPCKVTGRCGSVLVRLIPAPRGTGIVSAPVPKKLLMMAGIDDCYTSARGCTATLGNFAKATFDAISKTYSYLTPDLWKETVFTKSPYQE

--------------------------------------------------------------
>76067_76067_2_RPL18-RPS2_RPL18_chr19_49122397_ENST00000549273_RPS2_chr16_2013257_ENST00000526522_length(transcript)=516nt_BP=37nt
TCTTTCCGGACCTGGCCGAGCAGGAGGCGCCATCATGGAATCAGAGATCATTGATTTCTTCCTGGGGGCCTCTCTCAAGGATGAGGTTTT
GAAGATTATGCCAGTGCAGAAGCAGACCCGTGCCGGCCAGCGCACCAGGTTCAAGGTGACAGGCCGCTGCGGCTCTGTGCTGGTACGCCT
CATCCCTGCACCCAGGGGCACTGGCATCGTCTCCGCACCTGTGCCTAAGAAGCTGCTCATGATGGCTGGTATCGATGACTGCTACACCTC
AGCCCGGGGCTGCACTGCCACCCTGGGCAACTTCGCCAAGGCCACCTTTGATGCCATTTCTAAGACCTACAGCTACCTGACCCCCGACCT
CTGGAAGGAGACTGTATTCACCAAGTCTCCCTATCAGGAGTTCACTGACCACCTCGTCAAGACCCACACCAGAGTCTCCGTGCAGCGGAC

>76067_76067_2_RPL18-RPS2_RPL18_chr19_49122397_ENST00000549273_RPS2_chr16_2013257_ENST00000526522_length(amino acids)=147AA_BP=1
MESEIIDFFLGASLKDEVLKIMPVQKQTRAGQRTRFKVTGRCGSVLVRLIPAPRGTGIVSAPVPKKLLMMAGIDDCYTSARGCTATLGNF

--------------------------------------------------------------
>76067_76067_3_RPL18-RPS2_RPL18_chr19_49122397_ENST00000549273_RPS2_chr16_2013257_ENST00000529806_length(transcript)=666nt_BP=37nt
TCTTTCCGGACCTGGCCGAGCAGGAGGCGCCATCATGGAATCAGAGATCATTGATTTCTTCCTGGGGGCCTCTCTCAAGGATGAGGTTTT
GAAGATTATGCCAGTGCAGAAGCAGACCCGTGCCGGCCAGCGCACCAGGTTCAAGGCATTTGTTGCTATCGGGGACTACAATGGCCACGT
CGGTCTGGGTGTTAAGTGCTCCAAGGAGGTGGCCACCGCCATCCGTGGGGCCATCATCCTGGCCAAGCTCTCCATCGTCCCCGTGCGCAG
AGGCTACTGGGGGAACAAGATCGGCAAGCCCCACACTGTCCCTTGCAAGGTGACAGGCCGCTGCGGCTCTGTGCTGGTACGCCTCATCCC
TGCACCCAGGGGCACTGGCATCGTCTCCGCACCTGTGCCTAAGAAGCTGCTCATGATGGCTGGTATCGATGACTGCTACACCTCAGCCCG
GGGCTGCACTGCCACCCTGGGCAACTTCGGCCACCTTTGATGCCATTTCTAAGACCTACAGCTACCTGACCCCCGACCTCTGGAAGGAGA
CTGTATTCACCAAGTCTCCCTATCAGGAGTTCACTGACCACCTCGTCAAGACCCACACCAGAGTCTCCGTGCAGCGGACTCAGGCTCCAG

>76067_76067_3_RPL18-RPS2_RPL18_chr19_49122397_ENST00000549273_RPS2_chr16_2013257_ENST00000529806_length(amino acids)=151AA_BP=1
MESEIIDFFLGASLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPH

--------------------------------------------------------------
>76067_76067_4_RPL18-RPS2_RPL18_chr19_49122397_ENST00000549273_RPS2_chr16_2013257_ENST00000530225_length(transcript)=529nt_BP=37nt
TCTTTCCGGACCTGGCCGAGCAGGAGGCGCCATCATGGAATCAGAGATCATTGATTTCTTCCTGGGGGCCTCTCTCAAGGATGAGGTTTT
GAAGATTATGCCAGTGCAGAAGCAGACCCGTGCCGGCCAGCGCACCAGGTTCAAGGCATTTGTTGCTATCGGGGACTACAATGGCCACGT
CGGTCTGGGTGTTAAGTGCTCCAAGGAGGTGGCCACCGCCATCCGTGGGGCCATCATCCTGGCCAAGCTCTCCATCGTCCCCGTGCGCAG
AGGCTACTGGGGGAACAAGATCGGCAAGCCCCACACTGTCCCTTGCAAGCCAAGGCCACCTTTGATGCCATTTCTAAGACCTACAGCTAC
CTGACCCCCGACCTCTGGAAGGAGACTGTATTCACCAAGTCTCCCTATCAGGAGTTCACTGACCACCTCGTCAAGACCCACACCAGAGTC

>76067_76067_4_RPL18-RPS2_RPL18_chr19_49122397_ENST00000549273_RPS2_chr16_2013257_ENST00000530225_length(amino acids)=109AA_BP=1
MESEIIDFFLGASLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPH

--------------------------------------------------------------
>76067_76067_5_RPL18-RPS2_RPL18_chr19_49122397_ENST00000549920_RPS2_chr16_2013257_ENST00000343262_length(transcript)=1057nt_BP=396nt
ACTGGGCCCGCCGGGTCCTCCGGGAGCCACTGAGAGGCCGTCGGCGTCGGGCCAGAGCGTCACCGCGCGACGCATCGTGCTAGCTACACG
CATCTCGCTCCCAGATCCCTTTCTTCCGGAAAGCTATCGAGAACACGGCCTGGGTAGGGCCAGAGAGGCCCCCGACGTGCTGGCCCTTCC
CTCTTGGACGTTGCGCTTGTTCCTGCGCTCTATGCTCTCTGCCGTTATCGCCCGGCTAGTCAGTCGTCCAACTCACCACAGAGAAGTCCG
GATCGTGGTAGAGCGCCGCGTCGCACCCATGTGACGTCACGGCGGCGCCACTCGCTTGAGGCTTTCCCCGCCCACCCCAGCCCGTTCTCT
CTTTCCGGACCTGGCCGAGCAGGAGGCGCCATCATGGAATCAGAGATCATTGATTTCTTCCTGGGGGCCTCTCTCAAGGATGAGGTTTTG
AAGATTATGCCAGTGCAGAAGCAGACCCGTGCCGGCCAGCGCACCAGGTTCAAGGCATTTGTTGCTATCGGGGACTACAATGGCCACGTC
GGTCTGGGTGTTAAGTGCTCCAAGGAGGTGGCCACCGCCATCCGTGGGGCCATCATCCTGGCCAAGCTCTCCATCGTCCCCGTGCGCAGA
GGCTACTGGGGGAACAAGATCGGCAAGCCCCACACTGTCCCTTGCAAGGTGACAGGCCGCTGCGGCTCTGTGCTGGTACGCCTCATCCCT
GCACCCAGGGGCACTGGCATCGTCTCCGCACCTGTGCCTAAGAAGCTGCTCATGATGGCTGGTATCGATGACTGCTACACCTCAGCCCGG
GGCTGCACTGCCACCCTGGGCAACTTCGCCAAGGCCACCTTTGATGCCATTTCTAAGACCTACAGCTACCTGACCCCCGACCTCTGGAAG
GAGACTGTATTCACCAAGTCTCCCTATCAGGAGTTCACTGACCACCTCGTCAAGACCCACACCAGAGTCTCCGTGCAGCGGACTCAGGCT

>76067_76067_5_RPL18-RPS2_RPL18_chr19_49122397_ENST00000549920_RPS2_chr16_2013257_ENST00000343262_length(amino acids)=275AA_BP=55
MDVALVPALYALCRYRPASQSSNSPQRSPDRGRAPRRTHVTSRRRHSLEAFPAHPSPFSLSGPGRAGGAIMESEIIDFFLGASLKDEVLK
IMPVQKQTRAGQRTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPHTVPCKVTGRCGSVLVRLIPA
PRGTGIVSAPVPKKLLMMAGIDDCYTSARGCTATLGNFAKATFDAISKTYSYLTPDLWKETVFTKSPYQEFTDHLVKTHTRVSVQRTQAP

--------------------------------------------------------------
>76067_76067_6_RPL18-RPS2_RPL18_chr19_49122397_ENST00000549920_RPS2_chr16_2013257_ENST00000526522_length(transcript)=875nt_BP=396nt
ACTGGGCCCGCCGGGTCCTCCGGGAGCCACTGAGAGGCCGTCGGCGTCGGGCCAGAGCGTCACCGCGCGACGCATCGTGCTAGCTACACG
CATCTCGCTCCCAGATCCCTTTCTTCCGGAAAGCTATCGAGAACACGGCCTGGGTAGGGCCAGAGAGGCCCCCGACGTGCTGGCCCTTCC
CTCTTGGACGTTGCGCTTGTTCCTGCGCTCTATGCTCTCTGCCGTTATCGCCCGGCTAGTCAGTCGTCCAACTCACCACAGAGAAGTCCG
GATCGTGGTAGAGCGCCGCGTCGCACCCATGTGACGTCACGGCGGCGCCACTCGCTTGAGGCTTTCCCCGCCCACCCCAGCCCGTTCTCT
CTTTCCGGACCTGGCCGAGCAGGAGGCGCCATCATGGAATCAGAGATCATTGATTTCTTCCTGGGGGCCTCTCTCAAGGATGAGGTTTTG
AAGATTATGCCAGTGCAGAAGCAGACCCGTGCCGGCCAGCGCACCAGGTTCAAGGTGACAGGCCGCTGCGGCTCTGTGCTGGTACGCCTC
ATCCCTGCACCCAGGGGCACTGGCATCGTCTCCGCACCTGTGCCTAAGAAGCTGCTCATGATGGCTGGTATCGATGACTGCTACACCTCA
GCCCGGGGCTGCACTGCCACCCTGGGCAACTTCGCCAAGGCCACCTTTGATGCCATTTCTAAGACCTACAGCTACCTGACCCCCGACCTC
TGGAAGGAGACTGTATTCACCAAGTCTCCCTATCAGGAGTTCACTGACCACCTCGTCAAGACCCACACCAGAGTCTCCGTGCAGCGGACT

>76067_76067_6_RPL18-RPS2_RPL18_chr19_49122397_ENST00000549920_RPS2_chr16_2013257_ENST00000526522_length(amino acids)=217AA_BP=55
MDVALVPALYALCRYRPASQSSNSPQRSPDRGRAPRRTHVTSRRRHSLEAFPAHPSPFSLSGPGRAGGAIMESEIIDFFLGASLKDEVLK
IMPVQKQTRAGQRTRFKVTGRCGSVLVRLIPAPRGTGIVSAPVPKKLLMMAGIDDCYTSARGCTATLGNFAKATFDAISKTYSYLTPDLW

--------------------------------------------------------------
>76067_76067_7_RPL18-RPS2_RPL18_chr19_49122397_ENST00000549920_RPS2_chr16_2013257_ENST00000529806_length(transcript)=1025nt_BP=396nt
ACTGGGCCCGCCGGGTCCTCCGGGAGCCACTGAGAGGCCGTCGGCGTCGGGCCAGAGCGTCACCGCGCGACGCATCGTGCTAGCTACACG
CATCTCGCTCCCAGATCCCTTTCTTCCGGAAAGCTATCGAGAACACGGCCTGGGTAGGGCCAGAGAGGCCCCCGACGTGCTGGCCCTTCC
CTCTTGGACGTTGCGCTTGTTCCTGCGCTCTATGCTCTCTGCCGTTATCGCCCGGCTAGTCAGTCGTCCAACTCACCACAGAGAAGTCCG
GATCGTGGTAGAGCGCCGCGTCGCACCCATGTGACGTCACGGCGGCGCCACTCGCTTGAGGCTTTCCCCGCCCACCCCAGCCCGTTCTCT
CTTTCCGGACCTGGCCGAGCAGGAGGCGCCATCATGGAATCAGAGATCATTGATTTCTTCCTGGGGGCCTCTCTCAAGGATGAGGTTTTG
AAGATTATGCCAGTGCAGAAGCAGACCCGTGCCGGCCAGCGCACCAGGTTCAAGGCATTTGTTGCTATCGGGGACTACAATGGCCACGTC
GGTCTGGGTGTTAAGTGCTCCAAGGAGGTGGCCACCGCCATCCGTGGGGCCATCATCCTGGCCAAGCTCTCCATCGTCCCCGTGCGCAGA
GGCTACTGGGGGAACAAGATCGGCAAGCCCCACACTGTCCCTTGCAAGGTGACAGGCCGCTGCGGCTCTGTGCTGGTACGCCTCATCCCT
GCACCCAGGGGCACTGGCATCGTCTCCGCACCTGTGCCTAAGAAGCTGCTCATGATGGCTGGTATCGATGACTGCTACACCTCAGCCCGG
GGCTGCACTGCCACCCTGGGCAACTTCGGCCACCTTTGATGCCATTTCTAAGACCTACAGCTACCTGACCCCCGACCTCTGGAAGGAGAC
TGTATTCACCAAGTCTCCCTATCAGGAGTTCACTGACCACCTCGTCAAGACCCACACCAGAGTCTCCGTGCAGCGGACTCAGGCTCCAGC

>76067_76067_7_RPL18-RPS2_RPL18_chr19_49122397_ENST00000549920_RPS2_chr16_2013257_ENST00000529806_length(amino acids)=221AA_BP=55
MDVALVPALYALCRYRPASQSSNSPQRSPDRGRAPRRTHVTSRRRHSLEAFPAHPSPFSLSGPGRAGGAIMESEIIDFFLGASLKDEVLK
IMPVQKQTRAGQRTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPHTVPCKVTGRCGSVLVRLIPA

--------------------------------------------------------------
>76067_76067_8_RPL18-RPS2_RPL18_chr19_49122397_ENST00000549920_RPS2_chr16_2013257_ENST00000530225_length(transcript)=888nt_BP=396nt
ACTGGGCCCGCCGGGTCCTCCGGGAGCCACTGAGAGGCCGTCGGCGTCGGGCCAGAGCGTCACCGCGCGACGCATCGTGCTAGCTACACG
CATCTCGCTCCCAGATCCCTTTCTTCCGGAAAGCTATCGAGAACACGGCCTGGGTAGGGCCAGAGAGGCCCCCGACGTGCTGGCCCTTCC
CTCTTGGACGTTGCGCTTGTTCCTGCGCTCTATGCTCTCTGCCGTTATCGCCCGGCTAGTCAGTCGTCCAACTCACCACAGAGAAGTCCG
GATCGTGGTAGAGCGCCGCGTCGCACCCATGTGACGTCACGGCGGCGCCACTCGCTTGAGGCTTTCCCCGCCCACCCCAGCCCGTTCTCT
CTTTCCGGACCTGGCCGAGCAGGAGGCGCCATCATGGAATCAGAGATCATTGATTTCTTCCTGGGGGCCTCTCTCAAGGATGAGGTTTTG
AAGATTATGCCAGTGCAGAAGCAGACCCGTGCCGGCCAGCGCACCAGGTTCAAGGCATTTGTTGCTATCGGGGACTACAATGGCCACGTC
GGTCTGGGTGTTAAGTGCTCCAAGGAGGTGGCCACCGCCATCCGTGGGGCCATCATCCTGGCCAAGCTCTCCATCGTCCCCGTGCGCAGA
GGCTACTGGGGGAACAAGATCGGCAAGCCCCACACTGTCCCTTGCAAGCCAAGGCCACCTTTGATGCCATTTCTAAGACCTACAGCTACC
TGACCCCCGACCTCTGGAAGGAGACTGTATTCACCAAGTCTCCCTATCAGGAGTTCACTGACCACCTCGTCAAGACCCACACCAGAGTCT

>76067_76067_8_RPL18-RPS2_RPL18_chr19_49122397_ENST00000549920_RPS2_chr16_2013257_ENST00000530225_length(amino acids)=179AA_BP=55
MDVALVPALYALCRYRPASQSSNSPQRSPDRGRAPRRTHVTSRRRHSLEAFPAHPSPFSLSGPGRAGGAIMESEIIDFFLGASLKDEVLK

--------------------------------------------------------------
>76067_76067_9_RPL18-RPS2_RPL18_chr19_49122397_ENST00000550645_RPS2_chr16_2013257_ENST00000343262_length(transcript)=684nt_BP=23nt
GCCGAGCAGGAGGCGCCATCATGGAATCAGAGATCATTGATTTCTTCCTGGGGGCCTCTCTCAAGGATGAGGTTTTGAAGATTATGCCAG
TGCAGAAGCAGACCCGTGCCGGCCAGCGCACCAGGTTCAAGGCATTTGTTGCTATCGGGGACTACAATGGCCACGTCGGTCTGGGTGTTA
AGTGCTCCAAGGAGGTGGCCACCGCCATCCGTGGGGCCATCATCCTGGCCAAGCTCTCCATCGTCCCCGTGCGCAGAGGCTACTGGGGGA
ACAAGATCGGCAAGCCCCACACTGTCCCTTGCAAGGTGACAGGCCGCTGCGGCTCTGTGCTGGTACGCCTCATCCCTGCACCCAGGGGCA
CTGGCATCGTCTCCGCACCTGTGCCTAAGAAGCTGCTCATGATGGCTGGTATCGATGACTGCTACACCTCAGCCCGGGGCTGCACTGCCA
CCCTGGGCAACTTCGCCAAGGCCACCTTTGATGCCATTTCTAAGACCTACAGCTACCTGACCCCCGACCTCTGGAAGGAGACTGTATTCA
CCAAGTCTCCCTATCAGGAGTTCACTGACCACCTCGTCAAGACCCACACCAGAGTCTCCGTGCAGCGGACTCAGGCTCCAGCTGTGGCTA

>76067_76067_9_RPL18-RPS2_RPL18_chr19_49122397_ENST00000550645_RPS2_chr16_2013257_ENST00000343262_length(amino acids)=205AA_BP=1
MESEIIDFFLGASLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPH
TVPCKVTGRCGSVLVRLIPAPRGTGIVSAPVPKKLLMMAGIDDCYTSARGCTATLGNFAKATFDAISKTYSYLTPDLWKETVFTKSPYQE

--------------------------------------------------------------
>76067_76067_10_RPL18-RPS2_RPL18_chr19_49122397_ENST00000550645_RPS2_chr16_2013257_ENST00000526522_length(transcript)=502nt_BP=23nt
GCCGAGCAGGAGGCGCCATCATGGAATCAGAGATCATTGATTTCTTCCTGGGGGCCTCTCTCAAGGATGAGGTTTTGAAGATTATGCCAG
TGCAGAAGCAGACCCGTGCCGGCCAGCGCACCAGGTTCAAGGTGACAGGCCGCTGCGGCTCTGTGCTGGTACGCCTCATCCCTGCACCCA
GGGGCACTGGCATCGTCTCCGCACCTGTGCCTAAGAAGCTGCTCATGATGGCTGGTATCGATGACTGCTACACCTCAGCCCGGGGCTGCA
CTGCCACCCTGGGCAACTTCGCCAAGGCCACCTTTGATGCCATTTCTAAGACCTACAGCTACCTGACCCCCGACCTCTGGAAGGAGACTG
TATTCACCAAGTCTCCCTATCAGGAGTTCACTGACCACCTCGTCAAGACCCACACCAGAGTCTCCGTGCAGCGGACTCAGGCTCCAGCTG

>76067_76067_10_RPL18-RPS2_RPL18_chr19_49122397_ENST00000550645_RPS2_chr16_2013257_ENST00000526522_length(amino acids)=147AA_BP=1
MESEIIDFFLGASLKDEVLKIMPVQKQTRAGQRTRFKVTGRCGSVLVRLIPAPRGTGIVSAPVPKKLLMMAGIDDCYTSARGCTATLGNF

--------------------------------------------------------------
>76067_76067_11_RPL18-RPS2_RPL18_chr19_49122397_ENST00000550645_RPS2_chr16_2013257_ENST00000529806_length(transcript)=652nt_BP=23nt
GCCGAGCAGGAGGCGCCATCATGGAATCAGAGATCATTGATTTCTTCCTGGGGGCCTCTCTCAAGGATGAGGTTTTGAAGATTATGCCAG
TGCAGAAGCAGACCCGTGCCGGCCAGCGCACCAGGTTCAAGGCATTTGTTGCTATCGGGGACTACAATGGCCACGTCGGTCTGGGTGTTA
AGTGCTCCAAGGAGGTGGCCACCGCCATCCGTGGGGCCATCATCCTGGCCAAGCTCTCCATCGTCCCCGTGCGCAGAGGCTACTGGGGGA
ACAAGATCGGCAAGCCCCACACTGTCCCTTGCAAGGTGACAGGCCGCTGCGGCTCTGTGCTGGTACGCCTCATCCCTGCACCCAGGGGCA
CTGGCATCGTCTCCGCACCTGTGCCTAAGAAGCTGCTCATGATGGCTGGTATCGATGACTGCTACACCTCAGCCCGGGGCTGCACTGCCA
CCCTGGGCAACTTCGGCCACCTTTGATGCCATTTCTAAGACCTACAGCTACCTGACCCCCGACCTCTGGAAGGAGACTGTATTCACCAAG
TCTCCCTATCAGGAGTTCACTGACCACCTCGTCAAGACCCACACCAGAGTCTCCGTGCAGCGGACTCAGGCTCCAGCTGTGGCTACAACA

>76067_76067_11_RPL18-RPS2_RPL18_chr19_49122397_ENST00000550645_RPS2_chr16_2013257_ENST00000529806_length(amino acids)=151AA_BP=1
MESEIIDFFLGASLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPH

--------------------------------------------------------------
>76067_76067_12_RPL18-RPS2_RPL18_chr19_49122397_ENST00000550645_RPS2_chr16_2013257_ENST00000530225_length(transcript)=515nt_BP=23nt
GCCGAGCAGGAGGCGCCATCATGGAATCAGAGATCATTGATTTCTTCCTGGGGGCCTCTCTCAAGGATGAGGTTTTGAAGATTATGCCAG
TGCAGAAGCAGACCCGTGCCGGCCAGCGCACCAGGTTCAAGGCATTTGTTGCTATCGGGGACTACAATGGCCACGTCGGTCTGGGTGTTA
AGTGCTCCAAGGAGGTGGCCACCGCCATCCGTGGGGCCATCATCCTGGCCAAGCTCTCCATCGTCCCCGTGCGCAGAGGCTACTGGGGGA
ACAAGATCGGCAAGCCCCACACTGTCCCTTGCAAGCCAAGGCCACCTTTGATGCCATTTCTAAGACCTACAGCTACCTGACCCCCGACCT
CTGGAAGGAGACTGTATTCACCAAGTCTCCCTATCAGGAGTTCACTGACCACCTCGTCAAGACCCACACCAGAGTCTCCGTGCAGCGGAC

>76067_76067_12_RPL18-RPS2_RPL18_chr19_49122397_ENST00000550645_RPS2_chr16_2013257_ENST00000530225_length(amino acids)=109AA_BP=1
MESEIIDFFLGASLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPH

--------------------------------------------------------------
>76067_76067_13_RPL18-RPS2_RPL18_chr19_49122397_ENST00000552588_RPS2_chr16_2013257_ENST00000343262_length(transcript)=702nt_BP=41nt
TCTCTCTTTCCGGACCTGGCCGAGCAGGAGGCGCCATCATGGAATCAGAGATCATTGATTTCTTCCTGGGGGCCTCTCTCAAGGATGAGG
TTTTGAAGATTATGCCAGTGCAGAAGCAGACCCGTGCCGGCCAGCGCACCAGGTTCAAGGCATTTGTTGCTATCGGGGACTACAATGGCC
ACGTCGGTCTGGGTGTTAAGTGCTCCAAGGAGGTGGCCACCGCCATCCGTGGGGCCATCATCCTGGCCAAGCTCTCCATCGTCCCCGTGC
GCAGAGGCTACTGGGGGAACAAGATCGGCAAGCCCCACACTGTCCCTTGCAAGGTGACAGGCCGCTGCGGCTCTGTGCTGGTACGCCTCA
TCCCTGCACCCAGGGGCACTGGCATCGTCTCCGCACCTGTGCCTAAGAAGCTGCTCATGATGGCTGGTATCGATGACTGCTACACCTCAG
CCCGGGGCTGCACTGCCACCCTGGGCAACTTCGCCAAGGCCACCTTTGATGCCATTTCTAAGACCTACAGCTACCTGACCCCCGACCTCT
GGAAGGAGACTGTATTCACCAAGTCTCCCTATCAGGAGTTCACTGACCACCTCGTCAAGACCCACACCAGAGTCTCCGTGCAGCGGACTC

>76067_76067_13_RPL18-RPS2_RPL18_chr19_49122397_ENST00000552588_RPS2_chr16_2013257_ENST00000343262_length(amino acids)=205AA_BP=1
MESEIIDFFLGASLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPH
TVPCKVTGRCGSVLVRLIPAPRGTGIVSAPVPKKLLMMAGIDDCYTSARGCTATLGNFAKATFDAISKTYSYLTPDLWKETVFTKSPYQE

--------------------------------------------------------------
>76067_76067_14_RPL18-RPS2_RPL18_chr19_49122397_ENST00000552588_RPS2_chr16_2013257_ENST00000526522_length(transcript)=520nt_BP=41nt
TCTCTCTTTCCGGACCTGGCCGAGCAGGAGGCGCCATCATGGAATCAGAGATCATTGATTTCTTCCTGGGGGCCTCTCTCAAGGATGAGG
TTTTGAAGATTATGCCAGTGCAGAAGCAGACCCGTGCCGGCCAGCGCACCAGGTTCAAGGTGACAGGCCGCTGCGGCTCTGTGCTGGTAC
GCCTCATCCCTGCACCCAGGGGCACTGGCATCGTCTCCGCACCTGTGCCTAAGAAGCTGCTCATGATGGCTGGTATCGATGACTGCTACA
CCTCAGCCCGGGGCTGCACTGCCACCCTGGGCAACTTCGCCAAGGCCACCTTTGATGCCATTTCTAAGACCTACAGCTACCTGACCCCCG
ACCTCTGGAAGGAGACTGTATTCACCAAGTCTCCCTATCAGGAGTTCACTGACCACCTCGTCAAGACCCACACCAGAGTCTCCGTGCAGC

>76067_76067_14_RPL18-RPS2_RPL18_chr19_49122397_ENST00000552588_RPS2_chr16_2013257_ENST00000526522_length(amino acids)=147AA_BP=1
MESEIIDFFLGASLKDEVLKIMPVQKQTRAGQRTRFKVTGRCGSVLVRLIPAPRGTGIVSAPVPKKLLMMAGIDDCYTSARGCTATLGNF

--------------------------------------------------------------
>76067_76067_15_RPL18-RPS2_RPL18_chr19_49122397_ENST00000552588_RPS2_chr16_2013257_ENST00000529806_length(transcript)=670nt_BP=41nt
TCTCTCTTTCCGGACCTGGCCGAGCAGGAGGCGCCATCATGGAATCAGAGATCATTGATTTCTTCCTGGGGGCCTCTCTCAAGGATGAGG
TTTTGAAGATTATGCCAGTGCAGAAGCAGACCCGTGCCGGCCAGCGCACCAGGTTCAAGGCATTTGTTGCTATCGGGGACTACAATGGCC
ACGTCGGTCTGGGTGTTAAGTGCTCCAAGGAGGTGGCCACCGCCATCCGTGGGGCCATCATCCTGGCCAAGCTCTCCATCGTCCCCGTGC
GCAGAGGCTACTGGGGGAACAAGATCGGCAAGCCCCACACTGTCCCTTGCAAGGTGACAGGCCGCTGCGGCTCTGTGCTGGTACGCCTCA
TCCCTGCACCCAGGGGCACTGGCATCGTCTCCGCACCTGTGCCTAAGAAGCTGCTCATGATGGCTGGTATCGATGACTGCTACACCTCAG
CCCGGGGCTGCACTGCCACCCTGGGCAACTTCGGCCACCTTTGATGCCATTTCTAAGACCTACAGCTACCTGACCCCCGACCTCTGGAAG
GAGACTGTATTCACCAAGTCTCCCTATCAGGAGTTCACTGACCACCTCGTCAAGACCCACACCAGAGTCTCCGTGCAGCGGACTCAGGCT

>76067_76067_15_RPL18-RPS2_RPL18_chr19_49122397_ENST00000552588_RPS2_chr16_2013257_ENST00000529806_length(amino acids)=151AA_BP=1
MESEIIDFFLGASLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPH

--------------------------------------------------------------
>76067_76067_16_RPL18-RPS2_RPL18_chr19_49122397_ENST00000552588_RPS2_chr16_2013257_ENST00000530225_length(transcript)=533nt_BP=41nt
TCTCTCTTTCCGGACCTGGCCGAGCAGGAGGCGCCATCATGGAATCAGAGATCATTGATTTCTTCCTGGGGGCCTCTCTCAAGGATGAGG
TTTTGAAGATTATGCCAGTGCAGAAGCAGACCCGTGCCGGCCAGCGCACCAGGTTCAAGGCATTTGTTGCTATCGGGGACTACAATGGCC
ACGTCGGTCTGGGTGTTAAGTGCTCCAAGGAGGTGGCCACCGCCATCCGTGGGGCCATCATCCTGGCCAAGCTCTCCATCGTCCCCGTGC
GCAGAGGCTACTGGGGGAACAAGATCGGCAAGCCCCACACTGTCCCTTGCAAGCCAAGGCCACCTTTGATGCCATTTCTAAGACCTACAG
CTACCTGACCCCCGACCTCTGGAAGGAGACTGTATTCACCAAGTCTCCCTATCAGGAGTTCACTGACCACCTCGTCAAGACCCACACCAG

>76067_76067_16_RPL18-RPS2_RPL18_chr19_49122397_ENST00000552588_RPS2_chr16_2013257_ENST00000530225_length(amino acids)=109AA_BP=1
MESEIIDFFLGASLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPH

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for RPL18-RPS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for RPL18-RPS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for RPL18-RPS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource