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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATIC-RBM39 (FusionGDB2 ID:7633)

Fusion Gene Summary for ATIC-RBM39

check button Fusion gene summary
Fusion gene informationFusion gene name: ATIC-RBM39
Fusion gene ID: 7633
HgeneTgene
Gene symbol

ATIC

RBM39

Gene ID

471

9584

Gene name5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolaseRNA binding motif protein 39
SynonymsAICAR|AICARFT|HEL-S-70p|IMPCHASE|PURHCAPER|CAPERalpha|FSAP59|HCC1|RNPC2
Cytomap

2q35

20q11.22

Type of geneprotein-codingprotein-coding
Descriptionbifunctional purine biosynthesis protein PURH5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicaseAICAR formyltransferase/IMP cyclohydrolase bifunctional enzymeAICARFT/IMPCHASEepididymis secretory sperm binding protein Li 7RNA-binding protein 39CAPER alphaRNA-binding region (RNP1, RRM) containing 2coactivator of activating protein-1 and estrogen receptorsepididymis secretory sperm binding proteinfunctional spliceosome-associated protein 59hepatocellular carcinoma prot
Modification date2020031320200327
UniProtAcc

P31939

.
Ensembl transtripts involved in fusion geneENST00000236959, ENST00000435675, 
ENST00000540518, 		ENST00000397370, 
ENST00000407261, ENST00000463098, 
ENST00000253363, ENST00000361162, 
ENST00000528062, 
Fusion gene scores* DoF score9 X 9 X 4=32424 X 16 X 12=4608
# samples 927
** MAII scorelog2(9/324*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/4608*10)=-4.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATIC [Title/Abstract] AND RBM39 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATIC(216203630)-RBM39(34326939), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ATIC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RBM39 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-14-2554-01AATICchr2

216203630

+RBM39chr20

34326939

-


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Fusion Gene ORF analysis for ATIC-RBM39

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000236959ENST00000397370ATICchr2

216203630

+RBM39chr20

34326939

-
5CDS-5UTRENST00000236959ENST00000407261ATICchr2

216203630

+RBM39chr20

34326939

-
5CDS-5UTRENST00000435675ENST00000397370ATICchr2

216203630

+RBM39chr20

34326939

-
5CDS-5UTRENST00000435675ENST00000407261ATICchr2

216203630

+RBM39chr20

34326939

-
5CDS-5UTRENST00000540518ENST00000397370ATICchr2

216203630

+RBM39chr20

34326939

-
5CDS-5UTRENST00000540518ENST00000407261ATICchr2

216203630

+RBM39chr20

34326939

-
5CDS-intronENST00000236959ENST00000463098ATICchr2

216203630

+RBM39chr20

34326939

-
5CDS-intronENST00000435675ENST00000463098ATICchr2

216203630

+RBM39chr20

34326939

-
5CDS-intronENST00000540518ENST00000463098ATICchr2

216203630

+RBM39chr20

34326939

-
In-frameENST00000236959ENST00000253363ATICchr2

216203630

+RBM39chr20

34326939

-
In-frameENST00000236959ENST00000361162ATICchr2

216203630

+RBM39chr20

34326939

-
In-frameENST00000236959ENST00000528062ATICchr2

216203630

+RBM39chr20

34326939

-
In-frameENST00000435675ENST00000253363ATICchr2

216203630

+RBM39chr20

34326939

-
In-frameENST00000435675ENST00000361162ATICchr2

216203630

+RBM39chr20

34326939

-
In-frameENST00000435675ENST00000528062ATICchr2

216203630

+RBM39chr20

34326939

-
In-frameENST00000540518ENST00000253363ATICchr2

216203630

+RBM39chr20

34326939

-
In-frameENST00000540518ENST00000361162ATICchr2

216203630

+RBM39chr20

34326939

-
In-frameENST00000540518ENST00000528062ATICchr2

216203630

+RBM39chr20

34326939

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000236959ATICchr2216203630+ENST00000253363RBM39chr2034326939-396615532663094942
ENST00000236959ATICchr2216203630+ENST00000361162RBM39chr2034326939-394815532663076936
ENST00000236959ATICchr2216203630+ENST00000528062RBM39chr2034326939-361215532663028920
ENST00000540518ATICchr2216203630+ENST00000253363RBM39chr2034326939-394015272793068929
ENST00000540518ATICchr2216203630+ENST00000361162RBM39chr2034326939-392215272793050923
ENST00000540518ATICchr2216203630+ENST00000528062RBM39chr2034326939-358615272793002907
ENST00000435675ATICchr2216203630+ENST00000253363RBM39chr2034326939-402816153913156921
ENST00000435675ATICchr2216203630+ENST00000361162RBM39chr2034326939-401016153913138915
ENST00000435675ATICchr2216203630+ENST00000528062RBM39chr2034326939-367416153913090899

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000236959ENST00000253363ATICchr2216203630+RBM39chr2034326939-0.0006979610.999302
ENST00000236959ENST00000361162ATICchr2216203630+RBM39chr2034326939-0.0007713440.9992287
ENST00000236959ENST00000528062ATICchr2216203630+RBM39chr2034326939-0.0008732420.99912673
ENST00000540518ENST00000253363ATICchr2216203630+RBM39chr2034326939-0.0006757550.9993243
ENST00000540518ENST00000361162ATICchr2216203630+RBM39chr2034326939-0.0006931290.9993069
ENST00000540518ENST00000528062ATICchr2216203630+RBM39chr2034326939-0.0008140060.999186
ENST00000435675ENST00000253363ATICchr2216203630+RBM39chr2034326939-0.0003527910.99964726
ENST00000435675ENST00000361162ATICchr2216203630+RBM39chr2034326939-0.0003992980.9996007
ENST00000435675ENST00000528062ATICchr2216203630+RBM39chr2034326939-0.0004487910.99955124

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Fusion Genomic Features for ATIC-RBM39


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ATIC-RBM39


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:216203630/chr20:34326939)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATIC

P31939

.
FUNCTION: Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:9378707, PubMed:11948179, PubMed:10985775). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to IMP (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269|PubMed:10985775, ECO:0000269|PubMed:11948179, ECO:0000269|PubMed:14756554, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:9378707}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATICchr2:216203630chr20:34326939ENST00000236959+12162_146409593.0DomainMGS-like
HgeneATICchr2:216203630chr20:34326939ENST00000435675+11152_146408592.0DomainMGS-like
HgeneATICchr2:216203630chr20:34326939ENST00000236959+1216101_102409593.0Nucleotide bindingIMP
HgeneATICchr2:216203630chr20:34326939ENST00000236959+1216125_126409593.0Nucleotide bindingIMP
HgeneATICchr2:216203630chr20:34326939ENST00000236959+121612_14409593.0Nucleotide bindingIMP
HgeneATICchr2:216203630chr20:34326939ENST00000236959+121634_37409593.0Nucleotide bindingIMP
HgeneATICchr2:216203630chr20:34326939ENST00000236959+121664_67409593.0Nucleotide bindingIMP
HgeneATICchr2:216203630chr20:34326939ENST00000435675+1115101_102408592.0Nucleotide bindingIMP
HgeneATICchr2:216203630chr20:34326939ENST00000435675+1115125_126408592.0Nucleotide bindingIMP
HgeneATICchr2:216203630chr20:34326939ENST00000435675+111512_14408592.0Nucleotide bindingIMP
HgeneATICchr2:216203630chr20:34326939ENST00000435675+111534_37408592.0Nucleotide bindingIMP
HgeneATICchr2:216203630chr20:34326939ENST00000435675+111564_67408592.0Nucleotide bindingIMP
HgeneATICchr2:216203630chr20:34326939ENST00000236959+1216207_208409593.0RegionAICAR binding
HgeneATICchr2:216203630chr20:34326939ENST00000236959+12162_198409593.0RegionIMP cyclohydrolase
HgeneATICchr2:216203630chr20:34326939ENST00000435675+1115207_208408592.0RegionAICAR binding
HgeneATICchr2:216203630chr20:34326939ENST00000435675+11152_198408592.0RegionIMP cyclohydrolase
TgeneRBM39chr2:216203630chr20:34326939ENST00000253363117409_41617531.0Compositional biasNote=Poly-Ala
TgeneRBM39chr2:216203630chr20:34326939ENST0000025336311741_9017531.0Compositional biasNote=Arg/Ser-rich (RS domain)
TgeneRBM39chr2:216203630chr20:34326939ENST00000361162117409_41617525.0Compositional biasNote=Poly-Ala
TgeneRBM39chr2:216203630chr20:34326939ENST0000036116211741_9017525.0Compositional biasNote=Arg/Ser-rich (RS domain)
TgeneRBM39chr2:216203630chr20:34326939ENST00000528062116409_41617509.0Compositional biasNote=Poly-Ala
TgeneRBM39chr2:216203630chr20:34326939ENST0000052806211641_9017509.0Compositional biasNote=Arg/Ser-rich (RS domain)
TgeneRBM39chr2:216203630chr20:34326939ENST00000253363117153_23017531.0DomainRRM 1
TgeneRBM39chr2:216203630chr20:34326939ENST00000253363117250_32817531.0DomainRRM 2
TgeneRBM39chr2:216203630chr20:34326939ENST00000253363117445_50817531.0DomainRRM 3
TgeneRBM39chr2:216203630chr20:34326939ENST00000361162117153_23017525.0DomainRRM 1
TgeneRBM39chr2:216203630chr20:34326939ENST00000361162117250_32817525.0DomainRRM 2
TgeneRBM39chr2:216203630chr20:34326939ENST00000361162117445_50817525.0DomainRRM 3
TgeneRBM39chr2:216203630chr20:34326939ENST00000528062116153_23017509.0DomainRRM 1
TgeneRBM39chr2:216203630chr20:34326939ENST00000528062116250_32817509.0DomainRRM 2
TgeneRBM39chr2:216203630chr20:34326939ENST00000528062116445_50817509.0DomainRRM 3
TgeneRBM39chr2:216203630chr20:34326939ENST00000253363117291_35517531.0RegionActivating domain
TgeneRBM39chr2:216203630chr20:34326939ENST00000361162117291_35517525.0RegionActivating domain
TgeneRBM39chr2:216203630chr20:34326939ENST00000528062116291_35517509.0RegionActivating domain

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATICchr2:216203630chr20:34326939ENST00000236959+1216199_592409593.0RegionAICAR formyltransferase
HgeneATICchr2:216203630chr20:34326939ENST00000236959+1216565_566409593.0Region10-formyltetrahydrofolate binding
HgeneATICchr2:216203630chr20:34326939ENST00000435675+1115199_592408592.0RegionAICAR formyltransferase
HgeneATICchr2:216203630chr20:34326939ENST00000435675+1115565_566408592.0Region10-formyltetrahydrofolate binding


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Fusion Gene Sequence for ATIC-RBM39


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7633_7633_1_ATIC-RBM39_ATIC_chr2_216203630_ENST00000236959_RBM39_chr20_34326939_ENST00000253363_length(transcript)=3966nt_BP=1553nt
ACTTTGGGGTCGTGGGCAGATCGCTGGCTCCCACGCCTGGACTTCGGGATCGCAGGCAGGATCCCTTCCAGCCCAAGCACTCCGCCCAGG
CGCGCCAGGCAGAGCCCCACCCCATCCCGCCGTTCCCTTCAGCCCCGGGGCGCGGATCTTGCATCTGAAACTGAGCAGAGCAGGGCGCCG
GGCAGGGCCGGCGGGCCACGTGATAAGCCCGGAAACAGCTCCGCCCCCTCGCTTCCTGAGCCGCCACATCCCGGCAGCCCTCCTACCTGC
GCACGTGGTGCCGCCGCTGCTGCCTCCCGCTCGCCCTGAACCCAGTGCCTGCAGCCATGGCTCCCGGCCAGCTCGCCTTATTTAGTGTCT
CTGACAAAACCGGCCTTGTGGAATTTGCAAGAAACCTGACCGCTCTTGGTTTGAATCTGGTCGCTTCCGGAGGGACTGCAAAAGCTCTCA
GGGATGCTGGTCTGGCAGTCAGAGATGTCTCTGAGTTGACGGGATTTCCTGAAATGTTGGGGGGACGTGTGAAAACTTTGCATCCTGCAG
TCCATGCTGGAATCCTAGCTCGTAATATTCCAGAAGATAATGCTGACATGGCCAGACTTGATTTCAATCTTATAAGAGTTGTTGCCTGCA
ATCTCTATCCCTTTGTAAAGACAGTGGCTTCTCCAGGTGTAACTGTTGAGGAGGCTGTGGAGCAAATTGACATTGGTGGAGTAACCTTAC
TGAGAGCTGCAGCCAAAAACCACGCTCGAGTGACAGTGGTGTGTGAACCAGAGGACTATGTGGTGGTGTCCACGGAGATGCAGAGCTCCG
AGAGTAAGGACACCTCCTTGGAGACTAGACGCCAGTTAGCCTTGAAGGCATTCACTCATACGGCACAATATGATGAAGCAATTTCAGATT
ATTTCAGGAAACAGTACAGCAAAGGCGTATCTCAGATGCCCTTGAGATATGGAATGAACCCACATCAGACCCCTGCCCAGCTGTACACAC
TGCAGCCCAAGCTTCCCATCACAGTTCTAAATGGAGCCCCTGGATTTATAAACTTGTGCGATGCTTTGAACGCCTGGCAGCTGGTGAAGG
AACTCAAGGAGGCTTTAGGTATTCCAGCCGCTGCCTCTTTCAAACATGTCAGCCCAGCAGGTGCTGCTGTTGGAATTCCACTCAGTGAAG
ATGAGGCCAAAGTCTGCATGGTTTATGATCTCTATAAAACCCTCACACCCATCTCAGCGGCATATGCAAGAGCAAGAGGGGCTGATAGGA
TGTCTTCATTTGGTGATTTTGTTGCATTGTCCGATGTTTGTGATGTACCAACTGCAAAAATTATTTCCAGAGAAGTATCTGATGGTATAA
TTGCCCCAGGATATGAAGAAGAAGCCTTGACAATACTTTCCAAAAAGAAAAATGGAAACTATTGTGTCCTTCAGATGGACCAATCTTACA
AACCAGATGAAAATGAAGTTCGAACTCTCTTTGGTCTTCATTTAAGCCAGAAGAGAAATAATGGTGTCGTCGACAAGTCATTATTTAGCA
ATGTTGTTACCAAAAATAAAGATGATGAGAACAAGTTGAGCAGTGCCAACGGCCATGAAGAACGTAGCAAAAAGAGGAAAAAAAGCAAGA
GCAGAAGTCGTAGTCATGAACGAAAGAGAAGCAAAAGTAAGGAACGGAAGCGAAGTAGAGACAGAGAAAGGAAAAAGAGCAAAAGCCGTG
AAAGAAAGCGAAGTAGAAGCAAAGAGAGGCGACGGAGCCGCTCAAGAAGTCGAGATCGAAGATTTAGAGGCCGCTACAGAAGTCCTTACT
CCGGACCAAAATTTAACAGTGCCATCCGAGGAAAGATTGGGTTGCCTCATAGCATCAAATTAAGCAGACGACGTTCCCGAAGCAAAAGTC
CATTCAGAAAAGACAAGAGCCCTGTGAGAGAACCTATTGATAATTTAACTCCTGAGGAAAGAGATGCAAGGACAGTCTTCTGTATGCAGC
TGGCGGCAAGAATTCGACCAAGGGATTTGGAAGAGTTTTTCTCTACAGTAGGAAAGGTTCGAGATGTGAGGATGATTTCTGACAGAAATT
CAAGACGTTCCAAAGGAATTGCTTATGTGGAGTTCGTCGATGTTAGCTCAGTGCCTCTAGCAATAGGATTAACTGGCCAACGAGTTTTAG
GCGTGCCAATCATAGTACAGGCATCACAGGCAGAAAAAAACAGAGCTGCAGCAATGGCAAACAATTTACAAAAGGGAAGTGCTGGACCTA
TGAGGCTTTATGTGGGCTCATTACACTTCAACATAACTGAAGATATGCTTCGTGGGATCTTTGAGCCTTTTGGAAGAATTGAAAGTATCC
AGCTGATGATGGACAGTGAAACTGGTCGATCCAAGGGATATGGATTTATTACATTTTCTGACTCAGAATGTGCCAAAAAGGCTTTGGAAC
AACTTAATGGATTTGAACTAGCAGGAAGACCAATGAAAGTTGGTCATGTTACTGAACGTACTGATGCTTCGAGTGCTAGTTCATTTTTGG
ACAGTGATGAACTGGAAAGGACTGGAATTGATTTGGGAACAACTGGTCGTCTTCAGTTAATGGCAAGACTTGCAGAGGGTACAGGTTTGC
AGATTCCGCCAGCAGCACAGCAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGAATTCTCTTTTGTTATAGATTTGC
AAACAAGACTTTCCCAGCAGACTGAAGCTTCAGCTTTAGCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTA
ACATGTTTAACCCTCAAACAGAAGAAGAAGTTGGATGGGATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAG
TTATTCATATTTATGTTGACAAAAATTCAGCTCAGGGCAATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATG
CATTGCATGGCAGGTGGTTTGCTGGTAAAATGATAACAGCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGA
CAGCAACACAGCTACTGGTTCCAAGTAGACGATGAAGGAAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCT
TGAGTTATCTTTTATTTAGATAAAAATAAAGAGGCAAGGATCTACTGTCATTTGTATGCAATTTCCTGTTACCTTGAAAAAATAAAAATG
TTAACAGGAATGCAGTGTGCTCATTCTCCCTAAATAGTAAATCCCACTGTATACAAAACTGTTCTCTTGTTCTGCCTTTTAAAATGTTCA
TGTAGAAAATTAATGAACTATAGGAATAGCTCTAGGAGAACAAATGTGCTTTCTGTAAAAAGGCAGACCAGGGATGTAATGTTTTTAATG
TTTCAGAAGCCTAACTTTTTACACAGTGGTTACATTTCACATTTCACTAATGTTGATATTTGGCTGATGGTTGAGCAGTTTCTGAAATAC
ACATTTAGTGTATGGAAATACAAGACAGCTAAAGGGCTGTTTGGTTAGCATCTCATCTTGCATTCTGATCAATTGGCAAGAAAGGGAGAT
TTCAAAATTATATTTCTTGATGGTATCTTTTCAATTAATGTATCTGTAAAAGTTTCTTTGTAAATACTATGTGTTCTGGTGTGTCTTAAA
ATTCCAAACAAAATGATCCCTGCATTTCCTGAAGATGTTTAAACGTGAGAGTCTGGTAGGCAAAGCAGTCTGAGAAAGAAATAGGAAATG
CAGAAATAGGTTTTGTCTGGTTGCATATAATCTTTGCTCTTTTTAAGCTCTGTGAGCTCTGAAATATATTTTTGGGTTACTTCAGTGTGT
TTGACAAGACAGCTTGATATTTCTATCAAACAAATGACTTTCATATTGCAACAATCTTTGTAAGAACCACTCAAATAAAAGTCTCTTAAA

>7633_7633_1_ATIC-RBM39_ATIC_chr2_216203630_ENST00000236959_RBM39_chr20_34326939_ENST00000253363_length(amino acids)=942AA_BP=429
MRTWCRRCCLPLALNPVPAAMAPGQLALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEMLGGRVKTLHP
AVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQS
SESKDTSLETRRQLALKAFTHTAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINLCDALNAWQLV
KELKEALGIPAAASFKHVSPAGAAVGIPLSEDEAKVCMVYDLYKTLTPISAAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDG
IIAPGYEEEALTILSKKKNGNYCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDDENKLSSANGHEERSKKRKKS
KSRSRSHERKRSKSKERKRSRDRERKKSKSRERKRSRSKERRRSRSRSRDRRFRGRYRSPYSGPKFNSAIRGKIGLPHSIKLSRRRSRSK
SPFRKDKSPVREPIDNLTPEERDARTVFCMQLAARIRPRDLEEFFSTVGKVRDVRMISDRNSRRSKGIAYVEFVDVSSVPLAIGLTGQRV
LGVPIIVQASQAEKNRAAAMANNLQKGSAGPMRLYVGSLHFNITEDMLRGIFEPFGRIESIQLMMDSETGRSKGYGFITFSDSECAKKAL
EQLNGFELAGRPMKVGHVTERTDASSASSFLDSDELERTGIDLGTTGRLQLMARLAEGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVID
LQTRLSQQTEASALAAAASVQPLATQCFQLSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAV

--------------------------------------------------------------
>7633_7633_2_ATIC-RBM39_ATIC_chr2_216203630_ENST00000236959_RBM39_chr20_34326939_ENST00000361162_length(transcript)=3948nt_BP=1553nt
ACTTTGGGGTCGTGGGCAGATCGCTGGCTCCCACGCCTGGACTTCGGGATCGCAGGCAGGATCCCTTCCAGCCCAAGCACTCCGCCCAGG
CGCGCCAGGCAGAGCCCCACCCCATCCCGCCGTTCCCTTCAGCCCCGGGGCGCGGATCTTGCATCTGAAACTGAGCAGAGCAGGGCGCCG
GGCAGGGCCGGCGGGCCACGTGATAAGCCCGGAAACAGCTCCGCCCCCTCGCTTCCTGAGCCGCCACATCCCGGCAGCCCTCCTACCTGC
GCACGTGGTGCCGCCGCTGCTGCCTCCCGCTCGCCCTGAACCCAGTGCCTGCAGCCATGGCTCCCGGCCAGCTCGCCTTATTTAGTGTCT
CTGACAAAACCGGCCTTGTGGAATTTGCAAGAAACCTGACCGCTCTTGGTTTGAATCTGGTCGCTTCCGGAGGGACTGCAAAAGCTCTCA
GGGATGCTGGTCTGGCAGTCAGAGATGTCTCTGAGTTGACGGGATTTCCTGAAATGTTGGGGGGACGTGTGAAAACTTTGCATCCTGCAG
TCCATGCTGGAATCCTAGCTCGTAATATTCCAGAAGATAATGCTGACATGGCCAGACTTGATTTCAATCTTATAAGAGTTGTTGCCTGCA
ATCTCTATCCCTTTGTAAAGACAGTGGCTTCTCCAGGTGTAACTGTTGAGGAGGCTGTGGAGCAAATTGACATTGGTGGAGTAACCTTAC
TGAGAGCTGCAGCCAAAAACCACGCTCGAGTGACAGTGGTGTGTGAACCAGAGGACTATGTGGTGGTGTCCACGGAGATGCAGAGCTCCG
AGAGTAAGGACACCTCCTTGGAGACTAGACGCCAGTTAGCCTTGAAGGCATTCACTCATACGGCACAATATGATGAAGCAATTTCAGATT
ATTTCAGGAAACAGTACAGCAAAGGCGTATCTCAGATGCCCTTGAGATATGGAATGAACCCACATCAGACCCCTGCCCAGCTGTACACAC
TGCAGCCCAAGCTTCCCATCACAGTTCTAAATGGAGCCCCTGGATTTATAAACTTGTGCGATGCTTTGAACGCCTGGCAGCTGGTGAAGG
AACTCAAGGAGGCTTTAGGTATTCCAGCCGCTGCCTCTTTCAAACATGTCAGCCCAGCAGGTGCTGCTGTTGGAATTCCACTCAGTGAAG
ATGAGGCCAAAGTCTGCATGGTTTATGATCTCTATAAAACCCTCACACCCATCTCAGCGGCATATGCAAGAGCAAGAGGGGCTGATAGGA
TGTCTTCATTTGGTGATTTTGTTGCATTGTCCGATGTTTGTGATGTACCAACTGCAAAAATTATTTCCAGAGAAGTATCTGATGGTATAA
TTGCCCCAGGATATGAAGAAGAAGCCTTGACAATACTTTCCAAAAAGAAAAATGGAAACTATTGTGTCCTTCAGATGGACCAATCTTACA
AACCAGATGAAAATGAAGTTCGAACTCTCTTTGGTCTTCATTTAAGCCAGAAGAGAAATAATGGTGTCGTCGACAAGTCATTATTTAGCA
ATGTTGTTACCAAAAATAAAGATGATGAGAACAAGTTGAGCAGTGCCAACGGCCATGAAGAACGTAGCAAAAAGAGGAAAAAAAGCAAGA
GCAGAAGTCGTAGTCATGAACGAAAGAGAAGCAAAAGTAAGGAACGGAAGCGAAGTAGAGACAGAGAAAGGAAAAAGAGCAAAAGCCGTG
AAAGAAAGCGAAGTAGAAGCAAAGAGAGGCGACGGAGCCGCTCAAGAAGTCGAGATCGAAGATTTAGAGGCCGCTACAGAAGTCCTTACT
CCGGACCAAAATTTAACAGTGCCATCCGAGGAAAGATTGGGTTGCCTCATAGCATCAAATTAAGCAGACGACGTTCCCGAAGCAAAAGTC
CATTCAGAAAAGACAAGAGCCCTGTGAGAGAACCTATTGATAATTTAACTCCTGAGGAAAGAGATGCAAGGACAGTCTTCTGTATGCAGC
TGGCGGCAAGAATTCGACCAAGGGATTTGGAAGAGTTTTTCTCTACAGTAGGAAAGGTTCGAGATGTGAGGATGATTTCTGACAGAAATT
CAAGACGTTCCAAAGGAATTGCTTATGTGGAGTTCGTCGATGTTAGCTCAGTGCCTCTAGCAATAGGATTAACTGGCCAACGAGTTTTAG
GCGTGCCAATCATAGTACAGGCATCACAGGCAGAAAAAAACAGAGCTGCAGCAATGGCAAACAATTTACAAAAGGGAAGTGCTGGACCTA
TGAGGCTTTATGTGGGCTCATTACACTTCAACATAACTGAAGATATGCTTCGTGGGATCTTTGAGCCTTTTGGAAGAATTGAAAGTATCC
AGCTGATGATGGACAGTGAAACTGGTCGATCCAAGGGATATGGATTTATTACATTTTCTGACTCAGAATGTGCCAAAAAGGCTTTGGAAC
AACTTAATGGATTTGAACTAGCAGGAAGACCAATGAAAGTTGGTCATGTTACTGAACGTACTGATGCTTCGAGTGCTAGTTCATTTTTGG
ACAGTGATGAACTGGAAAGGACTGGAATTGATTTGGGAACAACTGGTCGTCTTCAGTTAATGGCAAGACTTGCAGAGGGTACAGGTTTGC
AGATTCCGCCAGCAGCACAGCAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGATTTGCAAACAAGACTTTCCCAGC
AGACTGAAGCTTCAGCTTTAGCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACATGTTTAACCCTCAAA
CAGAAGAAGAAGTTGGATGGGATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTATTCATATTTATGTTG
ACAAAAATTCAGCTCAGGGCAATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATTGCATGGCAGGTGGT
TTGCTGGTAAAATGATAACAGCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGCAACACAGCTACTGG
TTCCAAGTAGACGATGAAGGAAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAGTTATCTTTTATTTA
GATAAAAATAAAGAGGCAAGGATCTACTGTCATTTGTATGCAATTTCCTGTTACCTTGAAAAAATAAAAATGTTAACAGGAATGCAGTGT
GCTCATTCTCCCTAAATAGTAAATCCCACTGTATACAAAACTGTTCTCTTGTTCTGCCTTTTAAAATGTTCATGTAGAAAATTAATGAAC
TATAGGAATAGCTCTAGGAGAACAAATGTGCTTTCTGTAAAAAGGCAGACCAGGGATGTAATGTTTTTAATGTTTCAGAAGCCTAACTTT
TTACACAGTGGTTACATTTCACATTTCACTAATGTTGATATTTGGCTGATGGTTGAGCAGTTTCTGAAATACACATTTAGTGTATGGAAA
TACAAGACAGCTAAAGGGCTGTTTGGTTAGCATCTCATCTTGCATTCTGATCAATTGGCAAGAAAGGGAGATTTCAAAATTATATTTCTT
GATGGTATCTTTTCAATTAATGTATCTGTAAAAGTTTCTTTGTAAATACTATGTGTTCTGGTGTGTCTTAAAATTCCAAACAAAATGATC
CCTGCATTTCCTGAAGATGTTTAAACGTGAGAGTCTGGTAGGCAAAGCAGTCTGAGAAAGAAATAGGAAATGCAGAAATAGGTTTTGTCT
GGTTGCATATAATCTTTGCTCTTTTTAAGCTCTGTGAGCTCTGAAATATATTTTTGGGTTACTTCAGTGTGTTTGACAAGACAGCTTGAT

>7633_7633_2_ATIC-RBM39_ATIC_chr2_216203630_ENST00000236959_RBM39_chr20_34326939_ENST00000361162_length(amino acids)=936AA_BP=429
MRTWCRRCCLPLALNPVPAAMAPGQLALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEMLGGRVKTLHP
AVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQS
SESKDTSLETRRQLALKAFTHTAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINLCDALNAWQLV
KELKEALGIPAAASFKHVSPAGAAVGIPLSEDEAKVCMVYDLYKTLTPISAAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDG
IIAPGYEEEALTILSKKKNGNYCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDDENKLSSANGHEERSKKRKKS
KSRSRSHERKRSKSKERKRSRDRERKKSKSRERKRSRSKERRRSRSRSRDRRFRGRYRSPYSGPKFNSAIRGKIGLPHSIKLSRRRSRSK
SPFRKDKSPVREPIDNLTPEERDARTVFCMQLAARIRPRDLEEFFSTVGKVRDVRMISDRNSRRSKGIAYVEFVDVSSVPLAIGLTGQRV
LGVPIIVQASQAEKNRAAAMANNLQKGSAGPMRLYVGSLHFNITEDMLRGIFEPFGRIESIQLMMDSETGRSKGYGFITFSDSECAKKAL
EQLNGFELAGRPMKVGHVTERTDASSASSFLDSDELERTGIDLGTTGRLQLMARLAEGTGLQIPPAAQQALQMSGSLAFGAVADLQTRLS
QQTEASALAAAASVQPLATQCFQLSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGR

--------------------------------------------------------------
>7633_7633_3_ATIC-RBM39_ATIC_chr2_216203630_ENST00000236959_RBM39_chr20_34326939_ENST00000528062_length(transcript)=3612nt_BP=1553nt
ACTTTGGGGTCGTGGGCAGATCGCTGGCTCCCACGCCTGGACTTCGGGATCGCAGGCAGGATCCCTTCCAGCCCAAGCACTCCGCCCAGG
CGCGCCAGGCAGAGCCCCACCCCATCCCGCCGTTCCCTTCAGCCCCGGGGCGCGGATCTTGCATCTGAAACTGAGCAGAGCAGGGCGCCG
GGCAGGGCCGGCGGGCCACGTGATAAGCCCGGAAACAGCTCCGCCCCCTCGCTTCCTGAGCCGCCACATCCCGGCAGCCCTCCTACCTGC
GCACGTGGTGCCGCCGCTGCTGCCTCCCGCTCGCCCTGAACCCAGTGCCTGCAGCCATGGCTCCCGGCCAGCTCGCCTTATTTAGTGTCT
CTGACAAAACCGGCCTTGTGGAATTTGCAAGAAACCTGACCGCTCTTGGTTTGAATCTGGTCGCTTCCGGAGGGACTGCAAAAGCTCTCA
GGGATGCTGGTCTGGCAGTCAGAGATGTCTCTGAGTTGACGGGATTTCCTGAAATGTTGGGGGGACGTGTGAAAACTTTGCATCCTGCAG
TCCATGCTGGAATCCTAGCTCGTAATATTCCAGAAGATAATGCTGACATGGCCAGACTTGATTTCAATCTTATAAGAGTTGTTGCCTGCA
ATCTCTATCCCTTTGTAAAGACAGTGGCTTCTCCAGGTGTAACTGTTGAGGAGGCTGTGGAGCAAATTGACATTGGTGGAGTAACCTTAC
TGAGAGCTGCAGCCAAAAACCACGCTCGAGTGACAGTGGTGTGTGAACCAGAGGACTATGTGGTGGTGTCCACGGAGATGCAGAGCTCCG
AGAGTAAGGACACCTCCTTGGAGACTAGACGCCAGTTAGCCTTGAAGGCATTCACTCATACGGCACAATATGATGAAGCAATTTCAGATT
ATTTCAGGAAACAGTACAGCAAAGGCGTATCTCAGATGCCCTTGAGATATGGAATGAACCCACATCAGACCCCTGCCCAGCTGTACACAC
TGCAGCCCAAGCTTCCCATCACAGTTCTAAATGGAGCCCCTGGATTTATAAACTTGTGCGATGCTTTGAACGCCTGGCAGCTGGTGAAGG
AACTCAAGGAGGCTTTAGGTATTCCAGCCGCTGCCTCTTTCAAACATGTCAGCCCAGCAGGTGCTGCTGTTGGAATTCCACTCAGTGAAG
ATGAGGCCAAAGTCTGCATGGTTTATGATCTCTATAAAACCCTCACACCCATCTCAGCGGCATATGCAAGAGCAAGAGGGGCTGATAGGA
TGTCTTCATTTGGTGATTTTGTTGCATTGTCCGATGTTTGTGATGTACCAACTGCAAAAATTATTTCCAGAGAAGTATCTGATGGTATAA
TTGCCCCAGGATATGAAGAAGAAGCCTTGACAATACTTTCCAAAAAGAAAAATGGAAACTATTGTGTCCTTCAGATGGACCAATCTTACA
AACCAGATGAAAATGAAGTTCGAACTCTCTTTGGTCTTCATTTAAGCCAGAAGAGAAATAATGGTGTCGTCGACAAGTCATTATTTAGCA
ATGTTGTTACCAAAAATAAAGATGATGAGAACAAGTTGAGCAGTGCCAACGGCCATGAAGAACGTAGCAAAAAGAGGAAAAAAAGCAAGA
GCAGAAGTCGTAGTCATGAACGAAAGAGAAGCAAAAGTAAGGAACGGAAGCGAAGTAGAGACAGAGAAAGGAAAAAGAGCAAAAGCCGTG
AAAGAAAGCGAAGTAGAAGCAAAGAGAGGCGACGGAGCCGCTCAAGAAGTCGAGATCGAAGATTTAGAGGCCGCTACAGAAGTCCTTACA
GACGACGTTCCCGAAGCAAAAGTCCATTCAGAAAAGACAAGAGCCCTGTGAGAGAACCTATTGATAATTTAACTCCTGAGGAAAGAGATG
CAAGGACAGTCTTCTGTATGCAGCTGGCGGCAAGAATTCGACCAAGGGATTTGGAAGAGTTTTTCTCTACAGTAGGAAAGGTTCGAGATG
TGAGGATGATTTCTGACAGAAATTCAAGACGTTCCAAAGGAATTGCTTATGTGGAGTTCGTCGATGTTAGCTCAGTGCCTCTAGCAATAG
GATTAACTGGCCAACGAGTTTTAGGCGTGCCAATCATAGTACAGGCATCACAGGCAGAAAAAAACAGAGCTGCAGCAATGGCAAACAATT
TACAAAAGGGAAGTGCTGGACCTATGAGGCTTTATGTGGGCTCATTACACTTCAACATAACTGAAGATATGCTTCGTGGGATCTTTGAGC
CTTTTGGAAGAATTGAAAGTATCCAGCTGATGATGGACAGTGAAACTGGTCGATCCAAGGGATATGGATTTATTACATTTTCTGACTCAG
AATGTGCCAAAAAGGCTTTGGAACAACTTAATGGATTTGAACTAGCAGGAAGACCAATGAAAGTTGGTCATGTTACTGAACGTACTGATG
CTTCGAGTGCTAGTTCATTTTTGGACAGTGATGAACTGGAAAGGACTGGAATTGATTTGGGAACAACTGGTCGTCTTCAGTTAATGGCAA
GACTTGCAGAGGGTACAGGTTTGCAGATTCCGCCAGCAGCACAGCAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAG
AATTCTCTTTTGTTATAGATTTGCAAACAAGACTTTCCCAGCAGACTGAAGCTTCAGCTTTAGCTGCAGCTGCCTCTGTTCAGCCACTTG
CAACACAATGTTTCCAACTCTCTAACATGTTTAACCCTCAAACAGAAGAAGAAGTTGGATGGGATACCGAGATTAAGGATGATGTGATTG
AAGAATGTAATAAACATGGAGGAGTTATTCATATTTATGTTGACAAAAATTCAGCTCAGGGCAATGTGTATGTGAAGTGCCCATCAATTG
CTGCAGCTATTGCTGCTGTCAATGCATTGCATGGCAGGTGGTTTGCTGGTAAAATGATAACAGCAGCATATGTACCTCTTCCAACTTACC
ACAACCTGTTTCCTGATTCTATGACAGCAACACAGCTACTGGTTCCAAGTAGACGATGAAGGAAGATATAGTCCCTTATGTATATAGCTT
TTTTTCTTTCTTGAGAATTCATCTTGAGTTATCTTTTATTTAGATAAAAATAAAGAGGCAAGGATCTACTGTCATTTGTATGCAATTTCC
TGTTACCTTGAAAAAATAAAAATGTTAACAGGAATGCAGTGTGCTCATTCTCCCTAAATAGTAAATCCCACTGTATACAAAACTGTTCTC
TTGTTCTGCCTTTTAAAATGTTCATGTAGAAAATTAATGAACTATAGGAATAGCTCTAGGAGAACAAATGTGCTTTCTGTAAAAAGGCAG
ACCAGGGATGTAATGTTTTTAATGTTTCAGAAGCCTAACTTTTTACACAGTGGTTACATTTCACATTTCACTAATGTTGATATTTGGCTG
ATGGTTGAGCAGTTTCTGAAATACACATTTAGTGTATGGAAATACAAGACAGCTAAAGGGCTGTTTGGTTAGCATCTCATCTTGCATTCT
GATCAATTGGCAAGAAAGGGAGATTTCAAAATTATATTTCTTGATGGTATCTTTTCAATTAATGTATCTGTAAAAGTTTCTTTGTAAATA

>7633_7633_3_ATIC-RBM39_ATIC_chr2_216203630_ENST00000236959_RBM39_chr20_34326939_ENST00000528062_length(amino acids)=920AA_BP=429
MRTWCRRCCLPLALNPVPAAMAPGQLALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEMLGGRVKTLHP
AVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQS
SESKDTSLETRRQLALKAFTHTAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINLCDALNAWQLV
KELKEALGIPAAASFKHVSPAGAAVGIPLSEDEAKVCMVYDLYKTLTPISAAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDG
IIAPGYEEEALTILSKKKNGNYCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDDENKLSSANGHEERSKKRKKS
KSRSRSHERKRSKSKERKRSRDRERKKSKSRERKRSRSKERRRSRSRSRDRRFRGRYRSPYRRRSRSKSPFRKDKSPVREPIDNLTPEER
DARTVFCMQLAARIRPRDLEEFFSTVGKVRDVRMISDRNSRRSKGIAYVEFVDVSSVPLAIGLTGQRVLGVPIIVQASQAEKNRAAAMAN
NLQKGSAGPMRLYVGSLHFNITEDMLRGIFEPFGRIESIQLMMDSETGRSKGYGFITFSDSECAKKALEQLNGFELAGRPMKVGHVTERT
DASSASSFLDSDELERTGIDLGTTGRLQLMARLAEGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQP
LATQCFQLSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPT

--------------------------------------------------------------
>7633_7633_4_ATIC-RBM39_ATIC_chr2_216203630_ENST00000435675_RBM39_chr20_34326939_ENST00000253363_length(transcript)=4028nt_BP=1615nt
GTGGTGCCGCCGCTGCTGCCTCCCGCTCGCCCTGAACCCAGTGCCTGCAGCCATGGCTCCCGGCCAGCTCGGTGAGGCCCTAGCGGAGCG
GCGCGGTCTGCGTCCTCGCCTGCGGCCCCCCACGCTCCCGCCTTGGCGGCGGCCGGCGGGACCCGGCACTGCAGGGGCGGCGCTGCGGGA
TTGAAAGCCAGCGTCCCCGCTCCCCGGCCGGGCCGCAGCCTGCGTGGGGCCCGCCTTAGAGCAGCTCGCGGGTGTAAGACCTGGGGAGGC
CCGGACCAGGCCTGCGAACGCAGGGTCCAGGTGCTGGCCTTGCGATTCGAGAATCTCCTCCCCCAGACCCTCCCAAGGCCTTGCAGAACA
CAGTGCAATGTGCTGCGAATCATGAGAAAAAATGTCTTCTCTTTCAGCCTTATTTAGTGTCTCTGACAAAACCGGCCTTGTGGAATTTGC
AAGAAACCTGACCGCTCTTGGTTTGAATCTGGTCGCTTCCGGAGGGACTGCAAAAGCTCTCAGGGATGCTGGTCTGGCAGTCAGAGATGT
CTCTGAGTTGACGGGATTTCCTGAAATGTTGGGGGGACGTGTGAAAACTTTGCATCCTGCAGTCCATGCTGGAATCCTAGCTCGTAATAT
TCCAGAAGATAATGCTGACATGGCCAGACTTGATTTCAATCTTATAAGAGTTGTTGCCTGCAATCTCTATCCCTTTGTAAAGACAGTGGC
TTCTCCAGGTGTAACTGTTGAGGAGGCTGTGGAGCAAATTGACATTGGTGGAGTAACCTTACTGAGAGCTGCAGCCAAAAACCACGCTCG
AGTGACAGTGGTGTGTGAACCAGAGGACTATGTGGTGGTGTCCACGGAGATGCAGAGCTCCGAGAGTAAGGACACCTCCTTGGAGACTAG
ACGCCAGTTAGCCTTGAAGGCATTCACTCATACGGCACAATATGATGAAGCAATTTCAGATTATTTCAGGAAACAGTACAGCAAAGGCGT
ATCTCAGATGCCCTTGAGATATGGAATGAACCCACATCAGACCCCTGCCCAGCTGTACACACTGCAGCCCAAGCTTCCCATCACAGTTCT
AAATGGAGCCCCTGGATTTATAAACTTGTGCGATGCTTTGAACGCCTGGCAGCTGGTGAAGGAACTCAAGGAGGCTTTAGGTATTCCAGC
CGCTGCCTCTTTCAAACATGTCAGCCCAGCAGGTGCTGCTGTTGGAATTCCACTCAGTGAAGATGAGGCCAAAGTCTGCATGGTTTATGA
TCTCTATAAAACCCTCACACCCATCTCAGCGGCATATGCAAGAGCAAGAGGGGCTGATAGGATGTCTTCATTTGGTGATTTTGTTGCATT
GTCCGATGTTTGTGATGTACCAACTGCAAAAATTATTTCCAGAGAAGTATCTGATGGTATAATTGCCCCAGGATATGAAGAAGAAGCCTT
GACAATACTTTCCAAAAAGAAAAATGGAAACTATTGTGTCCTTCAGATGGACCAATCTTACAAACCAGATGAAAATGAAGTTCGAACTCT
CTTTGGTCTTCATTTAAGCCAGAAGAGAAATAATGGTGTCGTCGACAAGTCATTATTTAGCAATGTTGTTACCAAAAATAAAGATGATGA
GAACAAGTTGAGCAGTGCCAACGGCCATGAAGAACGTAGCAAAAAGAGGAAAAAAAGCAAGAGCAGAAGTCGTAGTCATGAACGAAAGAG
AAGCAAAAGTAAGGAACGGAAGCGAAGTAGAGACAGAGAAAGGAAAAAGAGCAAAAGCCGTGAAAGAAAGCGAAGTAGAAGCAAAGAGAG
GCGACGGAGCCGCTCAAGAAGTCGAGATCGAAGATTTAGAGGCCGCTACAGAAGTCCTTACTCCGGACCAAAATTTAACAGTGCCATCCG
AGGAAAGATTGGGTTGCCTCATAGCATCAAATTAAGCAGACGACGTTCCCGAAGCAAAAGTCCATTCAGAAAAGACAAGAGCCCTGTGAG
AGAACCTATTGATAATTTAACTCCTGAGGAAAGAGATGCAAGGACAGTCTTCTGTATGCAGCTGGCGGCAAGAATTCGACCAAGGGATTT
GGAAGAGTTTTTCTCTACAGTAGGAAAGGTTCGAGATGTGAGGATGATTTCTGACAGAAATTCAAGACGTTCCAAAGGAATTGCTTATGT
GGAGTTCGTCGATGTTAGCTCAGTGCCTCTAGCAATAGGATTAACTGGCCAACGAGTTTTAGGCGTGCCAATCATAGTACAGGCATCACA
GGCAGAAAAAAACAGAGCTGCAGCAATGGCAAACAATTTACAAAAGGGAAGTGCTGGACCTATGAGGCTTTATGTGGGCTCATTACACTT
CAACATAACTGAAGATATGCTTCGTGGGATCTTTGAGCCTTTTGGAAGAATTGAAAGTATCCAGCTGATGATGGACAGTGAAACTGGTCG
ATCCAAGGGATATGGATTTATTACATTTTCTGACTCAGAATGTGCCAAAAAGGCTTTGGAACAACTTAATGGATTTGAACTAGCAGGAAG
ACCAATGAAAGTTGGTCATGTTACTGAACGTACTGATGCTTCGAGTGCTAGTTCATTTTTGGACAGTGATGAACTGGAAAGGACTGGAAT
TGATTTGGGAACAACTGGTCGTCTTCAGTTAATGGCAAGACTTGCAGAGGGTACAGGTTTGCAGATTCCGCCAGCAGCACAGCAAGCTCT
ACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGAATTCTCTTTTGTTATAGATTTGCAAACAAGACTTTCCCAGCAGACTGAAGC
TTCAGCTTTAGCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACATGTTTAACCCTCAAACAGAAGAAGA
AGTTGGATGGGATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTATTCATATTTATGTTGACAAAAATTC
AGCTCAGGGCAATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATTGCATGGCAGGTGGTTTGCTGGTAA
AATGATAACAGCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGCAACACAGCTACTGGTTCCAAGTAG
ACGATGAAGGAAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAGTTATCTTTTATTTAGATAAAAATA
AAGAGGCAAGGATCTACTGTCATTTGTATGCAATTTCCTGTTACCTTGAAAAAATAAAAATGTTAACAGGAATGCAGTGTGCTCATTCTC
CCTAAATAGTAAATCCCACTGTATACAAAACTGTTCTCTTGTTCTGCCTTTTAAAATGTTCATGTAGAAAATTAATGAACTATAGGAATA
GCTCTAGGAGAACAAATGTGCTTTCTGTAAAAAGGCAGACCAGGGATGTAATGTTTTTAATGTTTCAGAAGCCTAACTTTTTACACAGTG
GTTACATTTCACATTTCACTAATGTTGATATTTGGCTGATGGTTGAGCAGTTTCTGAAATACACATTTAGTGTATGGAAATACAAGACAG
CTAAAGGGCTGTTTGGTTAGCATCTCATCTTGCATTCTGATCAATTGGCAAGAAAGGGAGATTTCAAAATTATATTTCTTGATGGTATCT
TTTCAATTAATGTATCTGTAAAAGTTTCTTTGTAAATACTATGTGTTCTGGTGTGTCTTAAAATTCCAAACAAAATGATCCCTGCATTTC
CTGAAGATGTTTAAACGTGAGAGTCTGGTAGGCAAAGCAGTCTGAGAAAGAAATAGGAAATGCAGAAATAGGTTTTGTCTGGTTGCATAT
AATCTTTGCTCTTTTTAAGCTCTGTGAGCTCTGAAATATATTTTTGGGTTACTTCAGTGTGTTTGACAAGACAGCTTGATATTTCTATCA

>7633_7633_4_ATIC-RBM39_ATIC_chr2_216203630_ENST00000435675_RBM39_chr20_34326939_ENST00000253363_length(amino acids)=921AA_BP=408
MSSLSALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILARNIPEDNADMARL
DFNLIRVVACNLYPFVKTVASPGVTVEEAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKAFTH
TAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINLCDALNAWQLVKELKEALGIPAAASFKHVSPA
GAAVGIPLSEDEAKVCMVYDLYKTLTPISAAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTILSKKKNGN
YCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDDENKLSSANGHEERSKKRKKSKSRSRSHERKRSKSKERKRSR
DRERKKSKSRERKRSRSKERRRSRSRSRDRRFRGRYRSPYSGPKFNSAIRGKIGLPHSIKLSRRRSRSKSPFRKDKSPVREPIDNLTPEE
RDARTVFCMQLAARIRPRDLEEFFSTVGKVRDVRMISDRNSRRSKGIAYVEFVDVSSVPLAIGLTGQRVLGVPIIVQASQAEKNRAAAMA
NNLQKGSAGPMRLYVGSLHFNITEDMLRGIFEPFGRIESIQLMMDSETGRSKGYGFITFSDSECAKKALEQLNGFELAGRPMKVGHVTER
TDASSASSFLDSDELERTGIDLGTTGRLQLMARLAEGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQ
PLATQCFQLSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLP

--------------------------------------------------------------
>7633_7633_5_ATIC-RBM39_ATIC_chr2_216203630_ENST00000435675_RBM39_chr20_34326939_ENST00000361162_length(transcript)=4010nt_BP=1615nt
GTGGTGCCGCCGCTGCTGCCTCCCGCTCGCCCTGAACCCAGTGCCTGCAGCCATGGCTCCCGGCCAGCTCGGTGAGGCCCTAGCGGAGCG
GCGCGGTCTGCGTCCTCGCCTGCGGCCCCCCACGCTCCCGCCTTGGCGGCGGCCGGCGGGACCCGGCACTGCAGGGGCGGCGCTGCGGGA
TTGAAAGCCAGCGTCCCCGCTCCCCGGCCGGGCCGCAGCCTGCGTGGGGCCCGCCTTAGAGCAGCTCGCGGGTGTAAGACCTGGGGAGGC
CCGGACCAGGCCTGCGAACGCAGGGTCCAGGTGCTGGCCTTGCGATTCGAGAATCTCCTCCCCCAGACCCTCCCAAGGCCTTGCAGAACA
CAGTGCAATGTGCTGCGAATCATGAGAAAAAATGTCTTCTCTTTCAGCCTTATTTAGTGTCTCTGACAAAACCGGCCTTGTGGAATTTGC
AAGAAACCTGACCGCTCTTGGTTTGAATCTGGTCGCTTCCGGAGGGACTGCAAAAGCTCTCAGGGATGCTGGTCTGGCAGTCAGAGATGT
CTCTGAGTTGACGGGATTTCCTGAAATGTTGGGGGGACGTGTGAAAACTTTGCATCCTGCAGTCCATGCTGGAATCCTAGCTCGTAATAT
TCCAGAAGATAATGCTGACATGGCCAGACTTGATTTCAATCTTATAAGAGTTGTTGCCTGCAATCTCTATCCCTTTGTAAAGACAGTGGC
TTCTCCAGGTGTAACTGTTGAGGAGGCTGTGGAGCAAATTGACATTGGTGGAGTAACCTTACTGAGAGCTGCAGCCAAAAACCACGCTCG
AGTGACAGTGGTGTGTGAACCAGAGGACTATGTGGTGGTGTCCACGGAGATGCAGAGCTCCGAGAGTAAGGACACCTCCTTGGAGACTAG
ACGCCAGTTAGCCTTGAAGGCATTCACTCATACGGCACAATATGATGAAGCAATTTCAGATTATTTCAGGAAACAGTACAGCAAAGGCGT
ATCTCAGATGCCCTTGAGATATGGAATGAACCCACATCAGACCCCTGCCCAGCTGTACACACTGCAGCCCAAGCTTCCCATCACAGTTCT
AAATGGAGCCCCTGGATTTATAAACTTGTGCGATGCTTTGAACGCCTGGCAGCTGGTGAAGGAACTCAAGGAGGCTTTAGGTATTCCAGC
CGCTGCCTCTTTCAAACATGTCAGCCCAGCAGGTGCTGCTGTTGGAATTCCACTCAGTGAAGATGAGGCCAAAGTCTGCATGGTTTATGA
TCTCTATAAAACCCTCACACCCATCTCAGCGGCATATGCAAGAGCAAGAGGGGCTGATAGGATGTCTTCATTTGGTGATTTTGTTGCATT
GTCCGATGTTTGTGATGTACCAACTGCAAAAATTATTTCCAGAGAAGTATCTGATGGTATAATTGCCCCAGGATATGAAGAAGAAGCCTT
GACAATACTTTCCAAAAAGAAAAATGGAAACTATTGTGTCCTTCAGATGGACCAATCTTACAAACCAGATGAAAATGAAGTTCGAACTCT
CTTTGGTCTTCATTTAAGCCAGAAGAGAAATAATGGTGTCGTCGACAAGTCATTATTTAGCAATGTTGTTACCAAAAATAAAGATGATGA
GAACAAGTTGAGCAGTGCCAACGGCCATGAAGAACGTAGCAAAAAGAGGAAAAAAAGCAAGAGCAGAAGTCGTAGTCATGAACGAAAGAG
AAGCAAAAGTAAGGAACGGAAGCGAAGTAGAGACAGAGAAAGGAAAAAGAGCAAAAGCCGTGAAAGAAAGCGAAGTAGAAGCAAAGAGAG
GCGACGGAGCCGCTCAAGAAGTCGAGATCGAAGATTTAGAGGCCGCTACAGAAGTCCTTACTCCGGACCAAAATTTAACAGTGCCATCCG
AGGAAAGATTGGGTTGCCTCATAGCATCAAATTAAGCAGACGACGTTCCCGAAGCAAAAGTCCATTCAGAAAAGACAAGAGCCCTGTGAG
AGAACCTATTGATAATTTAACTCCTGAGGAAAGAGATGCAAGGACAGTCTTCTGTATGCAGCTGGCGGCAAGAATTCGACCAAGGGATTT
GGAAGAGTTTTTCTCTACAGTAGGAAAGGTTCGAGATGTGAGGATGATTTCTGACAGAAATTCAAGACGTTCCAAAGGAATTGCTTATGT
GGAGTTCGTCGATGTTAGCTCAGTGCCTCTAGCAATAGGATTAACTGGCCAACGAGTTTTAGGCGTGCCAATCATAGTACAGGCATCACA
GGCAGAAAAAAACAGAGCTGCAGCAATGGCAAACAATTTACAAAAGGGAAGTGCTGGACCTATGAGGCTTTATGTGGGCTCATTACACTT
CAACATAACTGAAGATATGCTTCGTGGGATCTTTGAGCCTTTTGGAAGAATTGAAAGTATCCAGCTGATGATGGACAGTGAAACTGGTCG
ATCCAAGGGATATGGATTTATTACATTTTCTGACTCAGAATGTGCCAAAAAGGCTTTGGAACAACTTAATGGATTTGAACTAGCAGGAAG
ACCAATGAAAGTTGGTCATGTTACTGAACGTACTGATGCTTCGAGTGCTAGTTCATTTTTGGACAGTGATGAACTGGAAAGGACTGGAAT
TGATTTGGGAACAACTGGTCGTCTTCAGTTAATGGCAAGACTTGCAGAGGGTACAGGTTTGCAGATTCCGCCAGCAGCACAGCAAGCTCT
ACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGATTTGCAAACAAGACTTTCCCAGCAGACTGAAGCTTCAGCTTTAGCTGCAGC
TGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACATGTTTAACCCTCAAACAGAAGAAGAAGTTGGATGGGATACCGA
GATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTATTCATATTTATGTTGACAAAAATTCAGCTCAGGGCAATGTGTA
TGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATTGCATGGCAGGTGGTTTGCTGGTAAAATGATAACAGCAGCATA
TGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGCAACACAGCTACTGGTTCCAAGTAGACGATGAAGGAAGATATA
GTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAGTTATCTTTTATTTAGATAAAAATAAAGAGGCAAGGATCTACT
GTCATTTGTATGCAATTTCCTGTTACCTTGAAAAAATAAAAATGTTAACAGGAATGCAGTGTGCTCATTCTCCCTAAATAGTAAATCCCA
CTGTATACAAAACTGTTCTCTTGTTCTGCCTTTTAAAATGTTCATGTAGAAAATTAATGAACTATAGGAATAGCTCTAGGAGAACAAATG
TGCTTTCTGTAAAAAGGCAGACCAGGGATGTAATGTTTTTAATGTTTCAGAAGCCTAACTTTTTACACAGTGGTTACATTTCACATTTCA
CTAATGTTGATATTTGGCTGATGGTTGAGCAGTTTCTGAAATACACATTTAGTGTATGGAAATACAAGACAGCTAAAGGGCTGTTTGGTT
AGCATCTCATCTTGCATTCTGATCAATTGGCAAGAAAGGGAGATTTCAAAATTATATTTCTTGATGGTATCTTTTCAATTAATGTATCTG
TAAAAGTTTCTTTGTAAATACTATGTGTTCTGGTGTGTCTTAAAATTCCAAACAAAATGATCCCTGCATTTCCTGAAGATGTTTAAACGT
GAGAGTCTGGTAGGCAAAGCAGTCTGAGAAAGAAATAGGAAATGCAGAAATAGGTTTTGTCTGGTTGCATATAATCTTTGCTCTTTTTAA
GCTCTGTGAGCTCTGAAATATATTTTTGGGTTACTTCAGTGTGTTTGACAAGACAGCTTGATATTTCTATCAAACAAATGACTTTCATAT

>7633_7633_5_ATIC-RBM39_ATIC_chr2_216203630_ENST00000435675_RBM39_chr20_34326939_ENST00000361162_length(amino acids)=915AA_BP=408
MSSLSALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILARNIPEDNADMARL
DFNLIRVVACNLYPFVKTVASPGVTVEEAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKAFTH
TAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINLCDALNAWQLVKELKEALGIPAAASFKHVSPA
GAAVGIPLSEDEAKVCMVYDLYKTLTPISAAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTILSKKKNGN
YCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDDENKLSSANGHEERSKKRKKSKSRSRSHERKRSKSKERKRSR
DRERKKSKSRERKRSRSKERRRSRSRSRDRRFRGRYRSPYSGPKFNSAIRGKIGLPHSIKLSRRRSRSKSPFRKDKSPVREPIDNLTPEE
RDARTVFCMQLAARIRPRDLEEFFSTVGKVRDVRMISDRNSRRSKGIAYVEFVDVSSVPLAIGLTGQRVLGVPIIVQASQAEKNRAAAMA
NNLQKGSAGPMRLYVGSLHFNITEDMLRGIFEPFGRIESIQLMMDSETGRSKGYGFITFSDSECAKKALEQLNGFELAGRPMKVGHVTER
TDASSASSFLDSDELERTGIDLGTTGRLQLMARLAEGTGLQIPPAAQQALQMSGSLAFGAVADLQTRLSQQTEASALAAAASVQPLATQC
FQLSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLF

--------------------------------------------------------------
>7633_7633_6_ATIC-RBM39_ATIC_chr2_216203630_ENST00000435675_RBM39_chr20_34326939_ENST00000528062_length(transcript)=3674nt_BP=1615nt
GTGGTGCCGCCGCTGCTGCCTCCCGCTCGCCCTGAACCCAGTGCCTGCAGCCATGGCTCCCGGCCAGCTCGGTGAGGCCCTAGCGGAGCG
GCGCGGTCTGCGTCCTCGCCTGCGGCCCCCCACGCTCCCGCCTTGGCGGCGGCCGGCGGGACCCGGCACTGCAGGGGCGGCGCTGCGGGA
TTGAAAGCCAGCGTCCCCGCTCCCCGGCCGGGCCGCAGCCTGCGTGGGGCCCGCCTTAGAGCAGCTCGCGGGTGTAAGACCTGGGGAGGC
CCGGACCAGGCCTGCGAACGCAGGGTCCAGGTGCTGGCCTTGCGATTCGAGAATCTCCTCCCCCAGACCCTCCCAAGGCCTTGCAGAACA
CAGTGCAATGTGCTGCGAATCATGAGAAAAAATGTCTTCTCTTTCAGCCTTATTTAGTGTCTCTGACAAAACCGGCCTTGTGGAATTTGC
AAGAAACCTGACCGCTCTTGGTTTGAATCTGGTCGCTTCCGGAGGGACTGCAAAAGCTCTCAGGGATGCTGGTCTGGCAGTCAGAGATGT
CTCTGAGTTGACGGGATTTCCTGAAATGTTGGGGGGACGTGTGAAAACTTTGCATCCTGCAGTCCATGCTGGAATCCTAGCTCGTAATAT
TCCAGAAGATAATGCTGACATGGCCAGACTTGATTTCAATCTTATAAGAGTTGTTGCCTGCAATCTCTATCCCTTTGTAAAGACAGTGGC
TTCTCCAGGTGTAACTGTTGAGGAGGCTGTGGAGCAAATTGACATTGGTGGAGTAACCTTACTGAGAGCTGCAGCCAAAAACCACGCTCG
AGTGACAGTGGTGTGTGAACCAGAGGACTATGTGGTGGTGTCCACGGAGATGCAGAGCTCCGAGAGTAAGGACACCTCCTTGGAGACTAG
ACGCCAGTTAGCCTTGAAGGCATTCACTCATACGGCACAATATGATGAAGCAATTTCAGATTATTTCAGGAAACAGTACAGCAAAGGCGT
ATCTCAGATGCCCTTGAGATATGGAATGAACCCACATCAGACCCCTGCCCAGCTGTACACACTGCAGCCCAAGCTTCCCATCACAGTTCT
AAATGGAGCCCCTGGATTTATAAACTTGTGCGATGCTTTGAACGCCTGGCAGCTGGTGAAGGAACTCAAGGAGGCTTTAGGTATTCCAGC
CGCTGCCTCTTTCAAACATGTCAGCCCAGCAGGTGCTGCTGTTGGAATTCCACTCAGTGAAGATGAGGCCAAAGTCTGCATGGTTTATGA
TCTCTATAAAACCCTCACACCCATCTCAGCGGCATATGCAAGAGCAAGAGGGGCTGATAGGATGTCTTCATTTGGTGATTTTGTTGCATT
GTCCGATGTTTGTGATGTACCAACTGCAAAAATTATTTCCAGAGAAGTATCTGATGGTATAATTGCCCCAGGATATGAAGAAGAAGCCTT
GACAATACTTTCCAAAAAGAAAAATGGAAACTATTGTGTCCTTCAGATGGACCAATCTTACAAACCAGATGAAAATGAAGTTCGAACTCT
CTTTGGTCTTCATTTAAGCCAGAAGAGAAATAATGGTGTCGTCGACAAGTCATTATTTAGCAATGTTGTTACCAAAAATAAAGATGATGA
GAACAAGTTGAGCAGTGCCAACGGCCATGAAGAACGTAGCAAAAAGAGGAAAAAAAGCAAGAGCAGAAGTCGTAGTCATGAACGAAAGAG
AAGCAAAAGTAAGGAACGGAAGCGAAGTAGAGACAGAGAAAGGAAAAAGAGCAAAAGCCGTGAAAGAAAGCGAAGTAGAAGCAAAGAGAG
GCGACGGAGCCGCTCAAGAAGTCGAGATCGAAGATTTAGAGGCCGCTACAGAAGTCCTTACAGACGACGTTCCCGAAGCAAAAGTCCATT
CAGAAAAGACAAGAGCCCTGTGAGAGAACCTATTGATAATTTAACTCCTGAGGAAAGAGATGCAAGGACAGTCTTCTGTATGCAGCTGGC
GGCAAGAATTCGACCAAGGGATTTGGAAGAGTTTTTCTCTACAGTAGGAAAGGTTCGAGATGTGAGGATGATTTCTGACAGAAATTCAAG
ACGTTCCAAAGGAATTGCTTATGTGGAGTTCGTCGATGTTAGCTCAGTGCCTCTAGCAATAGGATTAACTGGCCAACGAGTTTTAGGCGT
GCCAATCATAGTACAGGCATCACAGGCAGAAAAAAACAGAGCTGCAGCAATGGCAAACAATTTACAAAAGGGAAGTGCTGGACCTATGAG
GCTTTATGTGGGCTCATTACACTTCAACATAACTGAAGATATGCTTCGTGGGATCTTTGAGCCTTTTGGAAGAATTGAAAGTATCCAGCT
GATGATGGACAGTGAAACTGGTCGATCCAAGGGATATGGATTTATTACATTTTCTGACTCAGAATGTGCCAAAAAGGCTTTGGAACAACT
TAATGGATTTGAACTAGCAGGAAGACCAATGAAAGTTGGTCATGTTACTGAACGTACTGATGCTTCGAGTGCTAGTTCATTTTTGGACAG
TGATGAACTGGAAAGGACTGGAATTGATTTGGGAACAACTGGTCGTCTTCAGTTAATGGCAAGACTTGCAGAGGGTACAGGTTTGCAGAT
TCCGCCAGCAGCACAGCAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGAATTCTCTTTTGTTATAGATTTGCAAAC
AAGACTTTCCCAGCAGACTGAAGCTTCAGCTTTAGCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACAT
GTTTAACCCTCAAACAGAAGAAGAAGTTGGATGGGATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTAT
TCATATTTATGTTGACAAAAATTCAGCTCAGGGCAATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATT
GCATGGCAGGTGGTTTGCTGGTAAAATGATAACAGCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGC
AACACAGCTACTGGTTCCAAGTAGACGATGAAGGAAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAG
TTATCTTTTATTTAGATAAAAATAAAGAGGCAAGGATCTACTGTCATTTGTATGCAATTTCCTGTTACCTTGAAAAAATAAAAATGTTAA
CAGGAATGCAGTGTGCTCATTCTCCCTAAATAGTAAATCCCACTGTATACAAAACTGTTCTCTTGTTCTGCCTTTTAAAATGTTCATGTA
GAAAATTAATGAACTATAGGAATAGCTCTAGGAGAACAAATGTGCTTTCTGTAAAAAGGCAGACCAGGGATGTAATGTTTTTAATGTTTC
AGAAGCCTAACTTTTTACACAGTGGTTACATTTCACATTTCACTAATGTTGATATTTGGCTGATGGTTGAGCAGTTTCTGAAATACACAT
TTAGTGTATGGAAATACAAGACAGCTAAAGGGCTGTTTGGTTAGCATCTCATCTTGCATTCTGATCAATTGGCAAGAAAGGGAGATTTCA

>7633_7633_6_ATIC-RBM39_ATIC_chr2_216203630_ENST00000435675_RBM39_chr20_34326939_ENST00000528062_length(amino acids)=899AA_BP=408
MSSLSALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILARNIPEDNADMARL
DFNLIRVVACNLYPFVKTVASPGVTVEEAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKAFTH
TAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINLCDALNAWQLVKELKEALGIPAAASFKHVSPA
GAAVGIPLSEDEAKVCMVYDLYKTLTPISAAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTILSKKKNGN
YCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDDENKLSSANGHEERSKKRKKSKSRSRSHERKRSKSKERKRSR
DRERKKSKSRERKRSRSKERRRSRSRSRDRRFRGRYRSPYRRRSRSKSPFRKDKSPVREPIDNLTPEERDARTVFCMQLAARIRPRDLEE
FFSTVGKVRDVRMISDRNSRRSKGIAYVEFVDVSSVPLAIGLTGQRVLGVPIIVQASQAEKNRAAAMANNLQKGSAGPMRLYVGSLHFNI
TEDMLRGIFEPFGRIESIQLMMDSETGRSKGYGFITFSDSECAKKALEQLNGFELAGRPMKVGHVTERTDASSASSFLDSDELERTGIDL
GTTGRLQLMARLAEGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPLATQCFQLSNMFNPQTEEEVG

--------------------------------------------------------------
>7633_7633_7_ATIC-RBM39_ATIC_chr2_216203630_ENST00000540518_RBM39_chr20_34326939_ENST00000253363_length(transcript)=3940nt_BP=1527nt
AGCCCTCCTACCTGCGCACGTGGTGCCGCCGCTGCTGCCTCCCGCTCGCCCTGAACCCAGTGCCTGCAGCCATGGCTCCCGGCCAGCTCG
GTGAGGCCCTAGCGGAGCGGCGCGGTCTGCGTCCTCGCCTGCGGCCCCCCACGCTCCCGCCTTGGCGGCGGCCGGCGGGACCCGGCACTG
CAGGGGCGGCGCTGCGGGATTGAAAGCCAGCGTCCCCGCTCCCCGGCCGGGCCGCAGCCTGCGTGGGGCCCGCCTTAGAGCAGCTCGCGG
GTGTAAGACCTGGGGAGGCCCGGACCAGGCCTGCGAACGCAGGGTCCAGCCTTATTTAGTGTCTCTGACAAAACCGGCCTTGTGGAATTT
GCAAGAAACCTGACCGCTCTTGGTTTGAATCTGGTCGCTTCCGGAGGGACTGCAAAAGCTCTCAGGGATGCTGGTCTGGCAGTCAGAGAT
GTCTCTGAGTTGACGGGATTTCCTGAAATGTTGGGGGGACGTGTGAAAACTTTGCATCCTGCAGTCCATGCTGGAATCCTAGCTCGTAAT
ATTCCAGAAGATAATGCTGACATGGCCAGACTTGATTTCAATCTTATAAGAGTTGTTGCCTGCAATCTCTATCCCTTTGTAAAGACAGTG
GCTTCTCCAGGTGTAACTGTTGAGGAGGCTGTGGAGCAAATTGACATTGGTGGAGTAACCTTACTGAGAGCTGCAGCCAAAAACCACGCT
CGAGTGACAGTGGTGTGTGAACCAGAGGACTATGTGGTGGTGTCCACGGAGATGCAGAGCTCCGAGAGTAAGGACACCTCCTTGGAGACT
AGACGCCAGTTAGCCTTGAAGGCATTCACTCATACGGCACAATATGATGAAGCAATTTCAGATTATTTCAGGAAACAGTACAGCAAAGGC
GTATCTCAGATGCCCTTGAGATATGGAATGAACCCACATCAGACCCCTGCCCAGCTGTACACACTGCAGCCCAAGCTTCCCATCACAGTT
CTAAATGGAGCCCCTGGATTTATAAACTTGTGCGATGCTTTGAACGCCTGGCAGCTGGTGAAGGAACTCAAGGAGGCTTTAGGTATTCCA
GCCGCTGCCTCTTTCAAACATGTCAGCCCAGCAGGTGCTGCTGTTGGAATTCCACTCAGTGAAGATGAGGCCAAAGTCTGCATGGTTTAT
GATCTCTATAAAACCCTCACACCCATCTCAGCGGCATATGCAAGAGCAAGAGGGGCTGATAGGATGTCTTCATTTGGTGATTTTGTTGCA
TTGTCCGATGTTTGTGATGTACCAACTGCAAAAATTATTTCCAGAGAAGTATCTGATGGTATAATTGCCCCAGGATATGAAGAAGAAGCC
TTGACAATACTTTCCAAAAAGAAAAATGGAAACTATTGTGTCCTTCAGATGGACCAATCTTACAAACCAGATGAAAATGAAGTTCGAACT
CTCTTTGGTCTTCATTTAAGCCAGAAGAGAAATAATGGTGTCGTCGACAAGTCATTATTTAGCAATGTTGTTACCAAAAATAAAGATGAT
GAGAACAAGTTGAGCAGTGCCAACGGCCATGAAGAACGTAGCAAAAAGAGGAAAAAAAGCAAGAGCAGAAGTCGTAGTCATGAACGAAAG
AGAAGCAAAAGTAAGGAACGGAAGCGAAGTAGAGACAGAGAAAGGAAAAAGAGCAAAAGCCGTGAAAGAAAGCGAAGTAGAAGCAAAGAG
AGGCGACGGAGCCGCTCAAGAAGTCGAGATCGAAGATTTAGAGGCCGCTACAGAAGTCCTTACTCCGGACCAAAATTTAACAGTGCCATC
CGAGGAAAGATTGGGTTGCCTCATAGCATCAAATTAAGCAGACGACGTTCCCGAAGCAAAAGTCCATTCAGAAAAGACAAGAGCCCTGTG
AGAGAACCTATTGATAATTTAACTCCTGAGGAAAGAGATGCAAGGACAGTCTTCTGTATGCAGCTGGCGGCAAGAATTCGACCAAGGGAT
TTGGAAGAGTTTTTCTCTACAGTAGGAAAGGTTCGAGATGTGAGGATGATTTCTGACAGAAATTCAAGACGTTCCAAAGGAATTGCTTAT
GTGGAGTTCGTCGATGTTAGCTCAGTGCCTCTAGCAATAGGATTAACTGGCCAACGAGTTTTAGGCGTGCCAATCATAGTACAGGCATCA
CAGGCAGAAAAAAACAGAGCTGCAGCAATGGCAAACAATTTACAAAAGGGAAGTGCTGGACCTATGAGGCTTTATGTGGGCTCATTACAC
TTCAACATAACTGAAGATATGCTTCGTGGGATCTTTGAGCCTTTTGGAAGAATTGAAAGTATCCAGCTGATGATGGACAGTGAAACTGGT
CGATCCAAGGGATATGGATTTATTACATTTTCTGACTCAGAATGTGCCAAAAAGGCTTTGGAACAACTTAATGGATTTGAACTAGCAGGA
AGACCAATGAAAGTTGGTCATGTTACTGAACGTACTGATGCTTCGAGTGCTAGTTCATTTTTGGACAGTGATGAACTGGAAAGGACTGGA
ATTGATTTGGGAACAACTGGTCGTCTTCAGTTAATGGCAAGACTTGCAGAGGGTACAGGTTTGCAGATTCCGCCAGCAGCACAGCAAGCT
CTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGAATTCTCTTTTGTTATAGATTTGCAAACAAGACTTTCCCAGCAGACTGAA
GCTTCAGCTTTAGCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACATGTTTAACCCTCAAACAGAAGAA
GAAGTTGGATGGGATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTATTCATATTTATGTTGACAAAAAT
TCAGCTCAGGGCAATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATTGCATGGCAGGTGGTTTGCTGGT
AAAATGATAACAGCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGCAACACAGCTACTGGTTCCAAGT
AGACGATGAAGGAAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAGTTATCTTTTATTTAGATAAAAA
TAAAGAGGCAAGGATCTACTGTCATTTGTATGCAATTTCCTGTTACCTTGAAAAAATAAAAATGTTAACAGGAATGCAGTGTGCTCATTC
TCCCTAAATAGTAAATCCCACTGTATACAAAACTGTTCTCTTGTTCTGCCTTTTAAAATGTTCATGTAGAAAATTAATGAACTATAGGAA
TAGCTCTAGGAGAACAAATGTGCTTTCTGTAAAAAGGCAGACCAGGGATGTAATGTTTTTAATGTTTCAGAAGCCTAACTTTTTACACAG
TGGTTACATTTCACATTTCACTAATGTTGATATTTGGCTGATGGTTGAGCAGTTTCTGAAATACACATTTAGTGTATGGAAATACAAGAC
AGCTAAAGGGCTGTTTGGTTAGCATCTCATCTTGCATTCTGATCAATTGGCAAGAAAGGGAGATTTCAAAATTATATTTCTTGATGGTAT
CTTTTCAATTAATGTATCTGTAAAAGTTTCTTTGTAAATACTATGTGTTCTGGTGTGTCTTAAAATTCCAAACAAAATGATCCCTGCATT
TCCTGAAGATGTTTAAACGTGAGAGTCTGGTAGGCAAAGCAGTCTGAGAAAGAAATAGGAAATGCAGAAATAGGTTTTGTCTGGTTGCAT
ATAATCTTTGCTCTTTTTAAGCTCTGTGAGCTCTGAAATATATTTTTGGGTTACTTCAGTGTGTTTGACAAGACAGCTTGATATTTCTAT

>7633_7633_7_ATIC-RBM39_ATIC_chr2_216203630_ENST00000540518_RBM39_chr20_34326939_ENST00000253363_length(amino acids)=929AA_BP=416
MGRPGPGLRTQGPALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILARNIPE
DNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQ
LALKAFTHTAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINLCDALNAWQLVKELKEALGIPAAA
SFKHVSPAGAAVGIPLSEDEAKVCMVYDLYKTLTPISAAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTI
LSKKKNGNYCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDDENKLSSANGHEERSKKRKKSKSRSRSHERKRSK
SKERKRSRDRERKKSKSRERKRSRSKERRRSRSRSRDRRFRGRYRSPYSGPKFNSAIRGKIGLPHSIKLSRRRSRSKSPFRKDKSPVREP
IDNLTPEERDARTVFCMQLAARIRPRDLEEFFSTVGKVRDVRMISDRNSRRSKGIAYVEFVDVSSVPLAIGLTGQRVLGVPIIVQASQAE
KNRAAAMANNLQKGSAGPMRLYVGSLHFNITEDMLRGIFEPFGRIESIQLMMDSETGRSKGYGFITFSDSECAKKALEQLNGFELAGRPM
KVGHVTERTDASSASSFLDSDELERTGIDLGTTGRLQLMARLAEGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASA
LAAAASVQPLATQCFQLSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMI

--------------------------------------------------------------
>7633_7633_8_ATIC-RBM39_ATIC_chr2_216203630_ENST00000540518_RBM39_chr20_34326939_ENST00000361162_length(transcript)=3922nt_BP=1527nt
AGCCCTCCTACCTGCGCACGTGGTGCCGCCGCTGCTGCCTCCCGCTCGCCCTGAACCCAGTGCCTGCAGCCATGGCTCCCGGCCAGCTCG
GTGAGGCCCTAGCGGAGCGGCGCGGTCTGCGTCCTCGCCTGCGGCCCCCCACGCTCCCGCCTTGGCGGCGGCCGGCGGGACCCGGCACTG
CAGGGGCGGCGCTGCGGGATTGAAAGCCAGCGTCCCCGCTCCCCGGCCGGGCCGCAGCCTGCGTGGGGCCCGCCTTAGAGCAGCTCGCGG
GTGTAAGACCTGGGGAGGCCCGGACCAGGCCTGCGAACGCAGGGTCCAGCCTTATTTAGTGTCTCTGACAAAACCGGCCTTGTGGAATTT
GCAAGAAACCTGACCGCTCTTGGTTTGAATCTGGTCGCTTCCGGAGGGACTGCAAAAGCTCTCAGGGATGCTGGTCTGGCAGTCAGAGAT
GTCTCTGAGTTGACGGGATTTCCTGAAATGTTGGGGGGACGTGTGAAAACTTTGCATCCTGCAGTCCATGCTGGAATCCTAGCTCGTAAT
ATTCCAGAAGATAATGCTGACATGGCCAGACTTGATTTCAATCTTATAAGAGTTGTTGCCTGCAATCTCTATCCCTTTGTAAAGACAGTG
GCTTCTCCAGGTGTAACTGTTGAGGAGGCTGTGGAGCAAATTGACATTGGTGGAGTAACCTTACTGAGAGCTGCAGCCAAAAACCACGCT
CGAGTGACAGTGGTGTGTGAACCAGAGGACTATGTGGTGGTGTCCACGGAGATGCAGAGCTCCGAGAGTAAGGACACCTCCTTGGAGACT
AGACGCCAGTTAGCCTTGAAGGCATTCACTCATACGGCACAATATGATGAAGCAATTTCAGATTATTTCAGGAAACAGTACAGCAAAGGC
GTATCTCAGATGCCCTTGAGATATGGAATGAACCCACATCAGACCCCTGCCCAGCTGTACACACTGCAGCCCAAGCTTCCCATCACAGTT
CTAAATGGAGCCCCTGGATTTATAAACTTGTGCGATGCTTTGAACGCCTGGCAGCTGGTGAAGGAACTCAAGGAGGCTTTAGGTATTCCA
GCCGCTGCCTCTTTCAAACATGTCAGCCCAGCAGGTGCTGCTGTTGGAATTCCACTCAGTGAAGATGAGGCCAAAGTCTGCATGGTTTAT
GATCTCTATAAAACCCTCACACCCATCTCAGCGGCATATGCAAGAGCAAGAGGGGCTGATAGGATGTCTTCATTTGGTGATTTTGTTGCA
TTGTCCGATGTTTGTGATGTACCAACTGCAAAAATTATTTCCAGAGAAGTATCTGATGGTATAATTGCCCCAGGATATGAAGAAGAAGCC
TTGACAATACTTTCCAAAAAGAAAAATGGAAACTATTGTGTCCTTCAGATGGACCAATCTTACAAACCAGATGAAAATGAAGTTCGAACT
CTCTTTGGTCTTCATTTAAGCCAGAAGAGAAATAATGGTGTCGTCGACAAGTCATTATTTAGCAATGTTGTTACCAAAAATAAAGATGAT
GAGAACAAGTTGAGCAGTGCCAACGGCCATGAAGAACGTAGCAAAAAGAGGAAAAAAAGCAAGAGCAGAAGTCGTAGTCATGAACGAAAG
AGAAGCAAAAGTAAGGAACGGAAGCGAAGTAGAGACAGAGAAAGGAAAAAGAGCAAAAGCCGTGAAAGAAAGCGAAGTAGAAGCAAAGAG
AGGCGACGGAGCCGCTCAAGAAGTCGAGATCGAAGATTTAGAGGCCGCTACAGAAGTCCTTACTCCGGACCAAAATTTAACAGTGCCATC
CGAGGAAAGATTGGGTTGCCTCATAGCATCAAATTAAGCAGACGACGTTCCCGAAGCAAAAGTCCATTCAGAAAAGACAAGAGCCCTGTG
AGAGAACCTATTGATAATTTAACTCCTGAGGAAAGAGATGCAAGGACAGTCTTCTGTATGCAGCTGGCGGCAAGAATTCGACCAAGGGAT
TTGGAAGAGTTTTTCTCTACAGTAGGAAAGGTTCGAGATGTGAGGATGATTTCTGACAGAAATTCAAGACGTTCCAAAGGAATTGCTTAT
GTGGAGTTCGTCGATGTTAGCTCAGTGCCTCTAGCAATAGGATTAACTGGCCAACGAGTTTTAGGCGTGCCAATCATAGTACAGGCATCA
CAGGCAGAAAAAAACAGAGCTGCAGCAATGGCAAACAATTTACAAAAGGGAAGTGCTGGACCTATGAGGCTTTATGTGGGCTCATTACAC
TTCAACATAACTGAAGATATGCTTCGTGGGATCTTTGAGCCTTTTGGAAGAATTGAAAGTATCCAGCTGATGATGGACAGTGAAACTGGT
CGATCCAAGGGATATGGATTTATTACATTTTCTGACTCAGAATGTGCCAAAAAGGCTTTGGAACAACTTAATGGATTTGAACTAGCAGGA
AGACCAATGAAAGTTGGTCATGTTACTGAACGTACTGATGCTTCGAGTGCTAGTTCATTTTTGGACAGTGATGAACTGGAAAGGACTGGA
ATTGATTTGGGAACAACTGGTCGTCTTCAGTTAATGGCAAGACTTGCAGAGGGTACAGGTTTGCAGATTCCGCCAGCAGCACAGCAAGCT
CTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGATTTGCAAACAAGACTTTCCCAGCAGACTGAAGCTTCAGCTTTAGCTGCA
GCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACATGTTTAACCCTCAAACAGAAGAAGAAGTTGGATGGGATACC
GAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTATTCATATTTATGTTGACAAAAATTCAGCTCAGGGCAATGTG
TATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATTGCATGGCAGGTGGTTTGCTGGTAAAATGATAACAGCAGCA
TATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGCAACACAGCTACTGGTTCCAAGTAGACGATGAAGGAAGATA
TAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAGTTATCTTTTATTTAGATAAAAATAAAGAGGCAAGGATCTA
CTGTCATTTGTATGCAATTTCCTGTTACCTTGAAAAAATAAAAATGTTAACAGGAATGCAGTGTGCTCATTCTCCCTAAATAGTAAATCC
CACTGTATACAAAACTGTTCTCTTGTTCTGCCTTTTAAAATGTTCATGTAGAAAATTAATGAACTATAGGAATAGCTCTAGGAGAACAAA
TGTGCTTTCTGTAAAAAGGCAGACCAGGGATGTAATGTTTTTAATGTTTCAGAAGCCTAACTTTTTACACAGTGGTTACATTTCACATTT
CACTAATGTTGATATTTGGCTGATGGTTGAGCAGTTTCTGAAATACACATTTAGTGTATGGAAATACAAGACAGCTAAAGGGCTGTTTGG
TTAGCATCTCATCTTGCATTCTGATCAATTGGCAAGAAAGGGAGATTTCAAAATTATATTTCTTGATGGTATCTTTTCAATTAATGTATC
TGTAAAAGTTTCTTTGTAAATACTATGTGTTCTGGTGTGTCTTAAAATTCCAAACAAAATGATCCCTGCATTTCCTGAAGATGTTTAAAC
GTGAGAGTCTGGTAGGCAAAGCAGTCTGAGAAAGAAATAGGAAATGCAGAAATAGGTTTTGTCTGGTTGCATATAATCTTTGCTCTTTTT
AAGCTCTGTGAGCTCTGAAATATATTTTTGGGTTACTTCAGTGTGTTTGACAAGACAGCTTGATATTTCTATCAAACAAATGACTTTCAT

>7633_7633_8_ATIC-RBM39_ATIC_chr2_216203630_ENST00000540518_RBM39_chr20_34326939_ENST00000361162_length(amino acids)=923AA_BP=416
MGRPGPGLRTQGPALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILARNIPE
DNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQ
LALKAFTHTAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINLCDALNAWQLVKELKEALGIPAAA
SFKHVSPAGAAVGIPLSEDEAKVCMVYDLYKTLTPISAAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTI
LSKKKNGNYCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDDENKLSSANGHEERSKKRKKSKSRSRSHERKRSK
SKERKRSRDRERKKSKSRERKRSRSKERRRSRSRSRDRRFRGRYRSPYSGPKFNSAIRGKIGLPHSIKLSRRRSRSKSPFRKDKSPVREP
IDNLTPEERDARTVFCMQLAARIRPRDLEEFFSTVGKVRDVRMISDRNSRRSKGIAYVEFVDVSSVPLAIGLTGQRVLGVPIIVQASQAE
KNRAAAMANNLQKGSAGPMRLYVGSLHFNITEDMLRGIFEPFGRIESIQLMMDSETGRSKGYGFITFSDSECAKKALEQLNGFELAGRPM
KVGHVTERTDASSASSFLDSDELERTGIDLGTTGRLQLMARLAEGTGLQIPPAAQQALQMSGSLAFGAVADLQTRLSQQTEASALAAAAS
VQPLATQCFQLSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVP

--------------------------------------------------------------
>7633_7633_9_ATIC-RBM39_ATIC_chr2_216203630_ENST00000540518_RBM39_chr20_34326939_ENST00000528062_length(transcript)=3586nt_BP=1527nt
AGCCCTCCTACCTGCGCACGTGGTGCCGCCGCTGCTGCCTCCCGCTCGCCCTGAACCCAGTGCCTGCAGCCATGGCTCCCGGCCAGCTCG
GTGAGGCCCTAGCGGAGCGGCGCGGTCTGCGTCCTCGCCTGCGGCCCCCCACGCTCCCGCCTTGGCGGCGGCCGGCGGGACCCGGCACTG
CAGGGGCGGCGCTGCGGGATTGAAAGCCAGCGTCCCCGCTCCCCGGCCGGGCCGCAGCCTGCGTGGGGCCCGCCTTAGAGCAGCTCGCGG
GTGTAAGACCTGGGGAGGCCCGGACCAGGCCTGCGAACGCAGGGTCCAGCCTTATTTAGTGTCTCTGACAAAACCGGCCTTGTGGAATTT
GCAAGAAACCTGACCGCTCTTGGTTTGAATCTGGTCGCTTCCGGAGGGACTGCAAAAGCTCTCAGGGATGCTGGTCTGGCAGTCAGAGAT
GTCTCTGAGTTGACGGGATTTCCTGAAATGTTGGGGGGACGTGTGAAAACTTTGCATCCTGCAGTCCATGCTGGAATCCTAGCTCGTAAT
ATTCCAGAAGATAATGCTGACATGGCCAGACTTGATTTCAATCTTATAAGAGTTGTTGCCTGCAATCTCTATCCCTTTGTAAAGACAGTG
GCTTCTCCAGGTGTAACTGTTGAGGAGGCTGTGGAGCAAATTGACATTGGTGGAGTAACCTTACTGAGAGCTGCAGCCAAAAACCACGCT
CGAGTGACAGTGGTGTGTGAACCAGAGGACTATGTGGTGGTGTCCACGGAGATGCAGAGCTCCGAGAGTAAGGACACCTCCTTGGAGACT
AGACGCCAGTTAGCCTTGAAGGCATTCACTCATACGGCACAATATGATGAAGCAATTTCAGATTATTTCAGGAAACAGTACAGCAAAGGC
GTATCTCAGATGCCCTTGAGATATGGAATGAACCCACATCAGACCCCTGCCCAGCTGTACACACTGCAGCCCAAGCTTCCCATCACAGTT
CTAAATGGAGCCCCTGGATTTATAAACTTGTGCGATGCTTTGAACGCCTGGCAGCTGGTGAAGGAACTCAAGGAGGCTTTAGGTATTCCA
GCCGCTGCCTCTTTCAAACATGTCAGCCCAGCAGGTGCTGCTGTTGGAATTCCACTCAGTGAAGATGAGGCCAAAGTCTGCATGGTTTAT
GATCTCTATAAAACCCTCACACCCATCTCAGCGGCATATGCAAGAGCAAGAGGGGCTGATAGGATGTCTTCATTTGGTGATTTTGTTGCA
TTGTCCGATGTTTGTGATGTACCAACTGCAAAAATTATTTCCAGAGAAGTATCTGATGGTATAATTGCCCCAGGATATGAAGAAGAAGCC
TTGACAATACTTTCCAAAAAGAAAAATGGAAACTATTGTGTCCTTCAGATGGACCAATCTTACAAACCAGATGAAAATGAAGTTCGAACT
CTCTTTGGTCTTCATTTAAGCCAGAAGAGAAATAATGGTGTCGTCGACAAGTCATTATTTAGCAATGTTGTTACCAAAAATAAAGATGAT
GAGAACAAGTTGAGCAGTGCCAACGGCCATGAAGAACGTAGCAAAAAGAGGAAAAAAAGCAAGAGCAGAAGTCGTAGTCATGAACGAAAG
AGAAGCAAAAGTAAGGAACGGAAGCGAAGTAGAGACAGAGAAAGGAAAAAGAGCAAAAGCCGTGAAAGAAAGCGAAGTAGAAGCAAAGAG
AGGCGACGGAGCCGCTCAAGAAGTCGAGATCGAAGATTTAGAGGCCGCTACAGAAGTCCTTACAGACGACGTTCCCGAAGCAAAAGTCCA
TTCAGAAAAGACAAGAGCCCTGTGAGAGAACCTATTGATAATTTAACTCCTGAGGAAAGAGATGCAAGGACAGTCTTCTGTATGCAGCTG
GCGGCAAGAATTCGACCAAGGGATTTGGAAGAGTTTTTCTCTACAGTAGGAAAGGTTCGAGATGTGAGGATGATTTCTGACAGAAATTCA
AGACGTTCCAAAGGAATTGCTTATGTGGAGTTCGTCGATGTTAGCTCAGTGCCTCTAGCAATAGGATTAACTGGCCAACGAGTTTTAGGC
GTGCCAATCATAGTACAGGCATCACAGGCAGAAAAAAACAGAGCTGCAGCAATGGCAAACAATTTACAAAAGGGAAGTGCTGGACCTATG
AGGCTTTATGTGGGCTCATTACACTTCAACATAACTGAAGATATGCTTCGTGGGATCTTTGAGCCTTTTGGAAGAATTGAAAGTATCCAG
CTGATGATGGACAGTGAAACTGGTCGATCCAAGGGATATGGATTTATTACATTTTCTGACTCAGAATGTGCCAAAAAGGCTTTGGAACAA
CTTAATGGATTTGAACTAGCAGGAAGACCAATGAAAGTTGGTCATGTTACTGAACGTACTGATGCTTCGAGTGCTAGTTCATTTTTGGAC
AGTGATGAACTGGAAAGGACTGGAATTGATTTGGGAACAACTGGTCGTCTTCAGTTAATGGCAAGACTTGCAGAGGGTACAGGTTTGCAG
ATTCCGCCAGCAGCACAGCAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGAATTCTCTTTTGTTATAGATTTGCAA
ACAAGACTTTCCCAGCAGACTGAAGCTTCAGCTTTAGCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAAC
ATGTTTAACCCTCAAACAGAAGAAGAAGTTGGATGGGATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTT
ATTCATATTTATGTTGACAAAAATTCAGCTCAGGGCAATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCA
TTGCATGGCAGGTGGTTTGCTGGTAAAATGATAACAGCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACA
GCAACACAGCTACTGGTTCCAAGTAGACGATGAAGGAAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTG
AGTTATCTTTTATTTAGATAAAAATAAAGAGGCAAGGATCTACTGTCATTTGTATGCAATTTCCTGTTACCTTGAAAAAATAAAAATGTT
AACAGGAATGCAGTGTGCTCATTCTCCCTAAATAGTAAATCCCACTGTATACAAAACTGTTCTCTTGTTCTGCCTTTTAAAATGTTCATG
TAGAAAATTAATGAACTATAGGAATAGCTCTAGGAGAACAAATGTGCTTTCTGTAAAAAGGCAGACCAGGGATGTAATGTTTTTAATGTT
TCAGAAGCCTAACTTTTTACACAGTGGTTACATTTCACATTTCACTAATGTTGATATTTGGCTGATGGTTGAGCAGTTTCTGAAATACAC
ATTTAGTGTATGGAAATACAAGACAGCTAAAGGGCTGTTTGGTTAGCATCTCATCTTGCATTCTGATCAATTGGCAAGAAAGGGAGATTT

>7633_7633_9_ATIC-RBM39_ATIC_chr2_216203630_ENST00000540518_RBM39_chr20_34326939_ENST00000528062_length(amino acids)=907AA_BP=416
MGRPGPGLRTQGPALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILARNIPE
DNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQ
LALKAFTHTAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINLCDALNAWQLVKELKEALGIPAAA
SFKHVSPAGAAVGIPLSEDEAKVCMVYDLYKTLTPISAAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTI
LSKKKNGNYCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDDENKLSSANGHEERSKKRKKSKSRSRSHERKRSK
SKERKRSRDRERKKSKSRERKRSRSKERRRSRSRSRDRRFRGRYRSPYRRRSRSKSPFRKDKSPVREPIDNLTPEERDARTVFCMQLAAR
IRPRDLEEFFSTVGKVRDVRMISDRNSRRSKGIAYVEFVDVSSVPLAIGLTGQRVLGVPIIVQASQAEKNRAAAMANNLQKGSAGPMRLY
VGSLHFNITEDMLRGIFEPFGRIESIQLMMDSETGRSKGYGFITFSDSECAKKALEQLNGFELAGRPMKVGHVTERTDASSASSFLDSDE
LERTGIDLGTTGRLQLMARLAEGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPLATQCFQLSNMFN
PQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPDSMTATQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ATIC-RBM39


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneRBM39chr2:216203630chr20:34326939ENST00000253363117355_40617.0531.0ESR1 and ESR2
TgeneRBM39chr2:216203630chr20:34326939ENST00000361162117355_40617.0525.0ESR1 and ESR2
TgeneRBM39chr2:216203630chr20:34326939ENST00000528062116355_40617.0509.0ESR1 and ESR2
TgeneRBM39chr2:216203630chr20:34326939ENST00000253363117291_40617.0531.0JUN
TgeneRBM39chr2:216203630chr20:34326939ENST00000361162117291_40617.0525.0JUN
TgeneRBM39chr2:216203630chr20:34326939ENST00000528062116291_40617.0509.0JUN
TgeneRBM39chr2:216203630chr20:34326939ENST00000253363117406_53017.0531.0NCOA6
TgeneRBM39chr2:216203630chr20:34326939ENST00000361162117406_53017.0525.0NCOA6
TgeneRBM39chr2:216203630chr20:34326939ENST00000528062116406_53017.0509.0NCOA6


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATIC-RBM39


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATIC-RBM39


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource