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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RPL27-NBR1 (FusionGDB2 ID:76349)

Fusion Gene Summary for RPL27-NBR1

check button Fusion gene summary
Fusion gene informationFusion gene name: RPL27-NBR1
Fusion gene ID: 76349
HgeneTgene
Gene symbol

RPL27

NBR1

Gene ID

6155

4077

Gene nameribosomal protein L27NBR1 autophagy cargo receptor
SynonymsDBA16|L271A1-3B|IAI3B|M17S2|MIG19
Cytomap

17q21.31

17q21.31

Type of geneprotein-codingprotein-coding
Description60S ribosomal protein L27large ribosomal subunit protein eL27next to BRCA1 gene 1 proteinB-box proteincell migration-inducing gene 19 proteinmembrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125)migration-inducing protein 19neighbor of BRCA1 gene 1
Modification date2020031320200313
UniProtAcc.

Q14596

Ensembl transtripts involved in fusion geneENST00000253788, ENST00000589037, 
ENST00000589913, ENST00000590864, 
ENST00000589872, ENST00000341165, 
ENST00000389312, ENST00000422280, 
ENST00000542611, ENST00000590996, 
Fusion gene scores* DoF score17 X 14 X 7=16666 X 7 X 5=210
# samples 217
** MAII scorelog2(21/1666*10)=-2.98792716769943
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPL27 [Title/Abstract] AND NBR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRPL27(41152119)-NBR1(41361920), # samples:1
RPL27(41150848)-NBR1(41348498), # samples:1
Anticipated loss of major functional domain due to fusion event.RPL27-NBR1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
RPL27-NBR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
RPL27-NBR1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNBR1

GO:0016236

macroautophagy

19250911


check buttonFusion gene breakpoints across RPL27 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NBR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-TM-A84F-01ARPL27chr17

41152119

+NBR1chr17

41361920

+
ChimerDB4THYMTCGA-ZB-A962-01ARPL27chr17

41150848

+NBR1chr17

41348498

+


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Fusion Gene ORF analysis for RPL27-NBR1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000253788ENST00000589872RPL27chr17

41152119

+NBR1chr17

41361920

+
5CDS-intronENST00000589037ENST00000589872RPL27chr17

41152119

+NBR1chr17

41361920

+
5CDS-intronENST00000589913ENST00000589872RPL27chr17

41152119

+NBR1chr17

41361920

+
5CDS-intronENST00000590864ENST00000589872RPL27chr17

41152119

+NBR1chr17

41361920

+
Frame-shiftENST00000253788ENST00000341165RPL27chr17

41150848

+NBR1chr17

41348498

+
Frame-shiftENST00000253788ENST00000389312RPL27chr17

41152119

+NBR1chr17

41361920

+
Frame-shiftENST00000253788ENST00000389312RPL27chr17

41150848

+NBR1chr17

41348498

+
Frame-shiftENST00000253788ENST00000422280RPL27chr17

41152119

+NBR1chr17

41361920

+
Frame-shiftENST00000253788ENST00000422280RPL27chr17

41150848

+NBR1chr17

41348498

+
Frame-shiftENST00000253788ENST00000542611RPL27chr17

41150848

+NBR1chr17

41348498

+
Frame-shiftENST00000253788ENST00000589872RPL27chr17

41150848

+NBR1chr17

41348498

+
Frame-shiftENST00000253788ENST00000590996RPL27chr17

41152119

+NBR1chr17

41361920

+
Frame-shiftENST00000253788ENST00000590996RPL27chr17

41150848

+NBR1chr17

41348498

+
Frame-shiftENST00000589037ENST00000341165RPL27chr17

41150848

+NBR1chr17

41348498

+
Frame-shiftENST00000589037ENST00000389312RPL27chr17

41152119

+NBR1chr17

41361920

+
Frame-shiftENST00000589037ENST00000389312RPL27chr17

41150848

+NBR1chr17

41348498

+
Frame-shiftENST00000589037ENST00000422280RPL27chr17

41152119

+NBR1chr17

41361920

+
Frame-shiftENST00000589037ENST00000422280RPL27chr17

41150848

+NBR1chr17

41348498

+
Frame-shiftENST00000589037ENST00000542611RPL27chr17

41150848

+NBR1chr17

41348498

+
Frame-shiftENST00000589037ENST00000589872RPL27chr17

41150848

+NBR1chr17

41348498

+
Frame-shiftENST00000589037ENST00000590996RPL27chr17

41152119

+NBR1chr17

41361920

+
Frame-shiftENST00000589037ENST00000590996RPL27chr17

41150848

+NBR1chr17

41348498

+
Frame-shiftENST00000589913ENST00000341165RPL27chr17

41150848

+NBR1chr17

41348498

+
Frame-shiftENST00000589913ENST00000389312RPL27chr17

41152119

+NBR1chr17

41361920

+
Frame-shiftENST00000589913ENST00000389312RPL27chr17

41150848

+NBR1chr17

41348498

+
Frame-shiftENST00000589913ENST00000422280RPL27chr17

41152119

+NBR1chr17

41361920

+
Frame-shiftENST00000589913ENST00000422280RPL27chr17

41150848

+NBR1chr17

41348498

+
Frame-shiftENST00000589913ENST00000542611RPL27chr17

41150848

+NBR1chr17

41348498

+
Frame-shiftENST00000589913ENST00000589872RPL27chr17

41150848

+NBR1chr17

41348498

+
Frame-shiftENST00000589913ENST00000590996RPL27chr17

41152119

+NBR1chr17

41361920

+
Frame-shiftENST00000589913ENST00000590996RPL27chr17

41150848

+NBR1chr17

41348498

+
Frame-shiftENST00000590864ENST00000389312RPL27chr17

41152119

+NBR1chr17

41361920

+
Frame-shiftENST00000590864ENST00000422280RPL27chr17

41152119

+NBR1chr17

41361920

+
Frame-shiftENST00000590864ENST00000590996RPL27chr17

41152119

+NBR1chr17

41361920

+
In-frameENST00000253788ENST00000341165RPL27chr17

41152119

+NBR1chr17

41361920

+
In-frameENST00000253788ENST00000542611RPL27chr17

41152119

+NBR1chr17

41361920

+
In-frameENST00000589037ENST00000341165RPL27chr17

41152119

+NBR1chr17

41361920

+
In-frameENST00000589037ENST00000542611RPL27chr17

41152119

+NBR1chr17

41361920

+
In-frameENST00000589913ENST00000341165RPL27chr17

41152119

+NBR1chr17

41361920

+
In-frameENST00000589913ENST00000542611RPL27chr17

41152119

+NBR1chr17

41361920

+
In-frameENST00000590864ENST00000341165RPL27chr17

41152119

+NBR1chr17

41361920

+
In-frameENST00000590864ENST00000542611RPL27chr17

41152119

+NBR1chr17

41361920

+
intron-3CDSENST00000590864ENST00000341165RPL27chr17

41150848

+NBR1chr17

41348498

+
intron-3CDSENST00000590864ENST00000389312RPL27chr17

41150848

+NBR1chr17

41348498

+
intron-3CDSENST00000590864ENST00000422280RPL27chr17

41150848

+NBR1chr17

41348498

+
intron-3CDSENST00000590864ENST00000542611RPL27chr17

41150848

+NBR1chr17

41348498

+
intron-3CDSENST00000590864ENST00000589872RPL27chr17

41150848

+NBR1chr17

41348498

+
intron-3CDSENST00000590864ENST00000590996RPL27chr17

41150848

+NBR1chr17

41348498

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000589037RPL27chr1741152119+ENST00000341165NBR1chr1741361920+218539614540285
ENST00000589037RPL27chr1741152119+ENST00000542611NBR1chr1741361920+48939614540285
ENST00000253788RPL27chr1741152119+ENST00000341165NBR1chr1741361920+20802914029785
ENST00000253788RPL27chr1741152119+ENST00000542611NBR1chr1741361920+3842914029785
ENST00000589913RPL27chr1741152119+ENST00000341165NBR1chr1741361920+2314525190531113
ENST00000589913RPL27chr1741152119+ENST00000542611NBR1chr1741361920+618525190531113
ENST00000590864RPL27chr1741152119+ENST00000341165NBR1chr1741361920+217038159136774
ENST00000590864RPL27chr1741152119+ENST00000542611NBR1chr1741361920+47438137920358

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000589037ENST00000341165RPL27chr1741152119+NBR1chr1741361920+0.121757460.8782425
ENST00000589037ENST00000542611RPL27chr1741152119+NBR1chr1741361920+0.105847550.8941524
ENST00000253788ENST00000341165RPL27chr1741152119+NBR1chr1741361920+0.064867880.9351321
ENST00000253788ENST00000542611RPL27chr1741152119+NBR1chr1741361920+0.081986370.9180136
ENST00000589913ENST00000341165RPL27chr1741152119+NBR1chr1741361920+0.08753430.9124657
ENST00000589913ENST00000542611RPL27chr1741152119+NBR1chr1741361920+0.0488459950.95115405
ENST00000590864ENST00000341165RPL27chr1741152119+NBR1chr1741361920+0.97316310.02683682
ENST00000590864ENST00000542611RPL27chr1741152119+NBR1chr1741361920+0.97670720.023292858

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Fusion Genomic Features for RPL27-NBR1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RPL27chr1741150848+NBR1chr1741348497+2.89E-050.99997115
RPL27chr1741152119+NBR1chr1741361919+6.51E-070.9999994
RPL27chr1741150848+NBR1chr1741348497+2.89E-050.99997115
RPL27chr1741152119+NBR1chr1741361919+6.51E-070.9999994

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RPL27-NBR1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:41152119/chr17:41361920)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NBR1

Q14596

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets. {ECO:0000269|PubMed:19250911}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRPL27chr17:41152119chr17:41361920ENST00000253788+355_4083137.0DomainNote=KOW
HgeneRPL27chr17:41152119chr17:41361920ENST00000589037+355_4083137.0DomainNote=KOW
HgeneRPL27chr17:41152119chr17:41361920ENST00000589913+245_4083137.0DomainNote=KOW
TgeneNBR1chr17:41152119chr17:41361920ENST00000589872021703_7140938.0Compositional biasNote=Poly-Glu
TgeneNBR1chr17:41152119chr17:41361920ENST000003411651921913_957909967.0DomainUBA
TgeneNBR1chr17:41152119chr17:41361920ENST000004222801921913_957909967.0DomainUBA
TgeneNBR1chr17:41152119chr17:41361920ENST000005898720214_850938.0DomainPB1
TgeneNBR1chr17:41152119chr17:41361920ENST00000589872021913_9570938.0DomainUBA
TgeneNBR1chr17:41152119chr17:41361920ENST000005909961921913_957909967.0DomainUBA
TgeneNBR1chr17:41152119chr17:41361920ENST00000589872021542_6360938.0RegionNote=ATG8 family protein-binding
TgeneNBR1chr17:41152119chr17:41361920ENST00000589872021727_7380938.0RegionNote=ATG8 family protein-binding
TgeneNBR1chr17:41152119chr17:41361920ENST00000589872021211_2570938.0Zinc fingerZZ-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNBR1chr17:41152119chr17:41361920ENST000003411651921703_714909967.0Compositional biasNote=Poly-Glu
TgeneNBR1chr17:41152119chr17:41361920ENST000004222801921703_714909967.0Compositional biasNote=Poly-Glu
TgeneNBR1chr17:41152119chr17:41361920ENST000005909961921703_714909967.0Compositional biasNote=Poly-Glu
TgeneNBR1chr17:41152119chr17:41361920ENST0000034116519214_85909967.0DomainPB1
TgeneNBR1chr17:41152119chr17:41361920ENST0000042228019214_85909967.0DomainPB1
TgeneNBR1chr17:41152119chr17:41361920ENST0000059099619214_85909967.0DomainPB1
TgeneNBR1chr17:41152119chr17:41361920ENST000003411651921542_636909967.0RegionNote=ATG8 family protein-binding
TgeneNBR1chr17:41152119chr17:41361920ENST000003411651921727_738909967.0RegionNote=ATG8 family protein-binding
TgeneNBR1chr17:41152119chr17:41361920ENST000004222801921542_636909967.0RegionNote=ATG8 family protein-binding
TgeneNBR1chr17:41152119chr17:41361920ENST000004222801921727_738909967.0RegionNote=ATG8 family protein-binding
TgeneNBR1chr17:41152119chr17:41361920ENST000005909961921542_636909967.0RegionNote=ATG8 family protein-binding
TgeneNBR1chr17:41152119chr17:41361920ENST000005909961921727_738909967.0RegionNote=ATG8 family protein-binding
TgeneNBR1chr17:41152119chr17:41361920ENST000003411651921211_257909967.0Zinc fingerZZ-type
TgeneNBR1chr17:41152119chr17:41361920ENST000004222801921211_257909967.0Zinc fingerZZ-type
TgeneNBR1chr17:41152119chr17:41361920ENST000005909961921211_257909967.0Zinc fingerZZ-type


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Fusion Gene Sequence for RPL27-NBR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>76349_76349_1_RPL27-NBR1_RPL27_chr17_41152119_ENST00000253788_NBR1_chr17_41361920_ENST00000341165_length(transcript)=2080nt_BP=291nt
CTTTCCTTTTTGCTGGTAGGGCCGGGTGGTTGCTGCCGAAATGGGCAAGTTCATGAAACCTGGGAAGGTGGTGCTTGTCCTGGCTGGACG
CTACTCCGGACGCAAAGCTGTCATCGTGAAGAACATTGATGATGGCACCTCAGATCGCCCCTACAGCCATGCTCTGGTGGCTGGAATTGA
CCGCTACCCCCGCAAAGTGACAGCTGCCATGGGCAAGAAGAAGATCGCCAAGAGATCAAAGATAAAATCTTTTGTGAAAGTGTATAACTA
CAATCACCTAATGCCCACAAGCCAATAATTTCTGAAGATCAGACAGCAGCCCTGATGGCCCATCTCTTTGAAATGGGATTCTGTGACAGG
CAGCTGAACCTACGGCTGCTGAAGAAACACAATTACAATATCCTGCAGGTTGTGACAGAACTTCTTCAGTTAAACAACAACGACTGGTAC
AGCCAACGCTATTGAGGAGTGACCTTGTATTAAATAACTGCCTGCTGCTCAGAGATGATCTTTATTCTGTCATTGGGGTATGGGATAGAA
GCCCTTGCTTATTTTTAATCTGATGAATCTGTATAGAGCCCATCGTTGAGTTACCAAGACAATACCTGCTACAGTATTTTGGGGAGCAAA
CTAAAGACCAGAACTTAAATTTTCACTTTAGACATTGGATGAATAGTATGAAGACAGTTTTTCAGTTGATTTGGATAAAACTATTTTAGT
GCATTGACAAGTGTAACTTCAACTTCATATAGAACCATTTTTCTTTCTGCTTTTATTGAAACTGAGTATTTTTCTTTGGCTAATGTGGAT
TTTTTATGGGGATATCTGTTAATTTTCAGGTTTTGAAAGACATTAACCTCGGAAGTTGTTTTTAAGAATTATTCTCATAATTCTTATTCT
CATAATTTCTGTAATCCACCTCAAGCTTCATAGTTATTTGGCATTGAAATAACACCCAGAGCATGATAGAAATGTTGTTACTCTTCCTCT
CTCAAGGAGAAAGTAATTTTCCTGCAATACTTAATAATTGGCACCGTTGCTTTCTAAAGACTCCATGGTGCATTCAAGAGTATCCAACTT
CAAGGGAATCTCCGCATTTCAATGAAAGGAGGAAGAGTGTGCTGATAAACCTACCAGCACCTATTGAGCAATGTCTATTATAGTAATTTT
GCATACATTTTTATTTAAGGGAAAAAATATAGGTATTGTGAAATATTTTGCTAATCTTATAGAAAAGGAAAAAATCCCGTTATTTAAAGG
GAAAAGTAAATTTAACAGTTGCCTTTTTTCTTAATGTCAGGGCAGATCTTATTTTACAGTACAGTGGGGGAAATAGAAACATGTGAAAGG
CAAAAGGCAGGCTCCTAAATTAATGTCAGTGAAGTTCAGGGTGGGCAAATGAGTGTGTGTGAGGTATAGGAAATGCTGATGACTTCTTTA
ATGCTTGAAGTCCGTTCACAGGTATCTAGCCCTAGAATGCCTAGAACAGGAAGAGGCAGCTGGTGTTCTGCAAAACTTGGACAGGGGCAA
AGTTGCTGAAAAAGTTTTGGTTTAACCCGAAGATAAGTGGAAAAGAGCTTGTCCATGAACCCAGGTTCTCACTCTGTTTACAGAAGTGTG
TTGAGTACAGTTGGTGAAGGAAGAGGTAACAAAAAATGCTAAATATTTTATCCATGAAAATGACTTCCAGAAAAGGAAGAATATGAACCC
CAGACCGAAGGGGAAAAGATAGTTAATAGTATTATCTAACCTGGTTGGTATTTGTAATGAATGGTGATTTTAATTAGTCATTAGCCATAA
TGATGTTTATTTACAGTATAACTCCTGAATGCTACTTAAATAAACCAGGATTCAAACTGCAAGCCAGCCAGGCCGTTCATTATTTAAAAC
GTTTTAATCGGGGCTTCCGGGTAGAAGGTGGAGCGGCAGGGTGTAATTGGGTTGATGGGTGGGACCTGTCTTGACCATCGGAGTTTTATA
ATCGAGGGCCAGGAGGGCCCGGGTTGCTCTCCTGGTTATGTATGTACTTGTACATAACCACCTAAAGAATGGTGAAATAAATGTTCTTGG

>76349_76349_1_RPL27-NBR1_RPL27_chr17_41152119_ENST00000253788_NBR1_chr17_41361920_ENST00000341165_length(amino acids)=85AA_BP=

--------------------------------------------------------------
>76349_76349_2_RPL27-NBR1_RPL27_chr17_41152119_ENST00000253788_NBR1_chr17_41361920_ENST00000542611_length(transcript)=384nt_BP=291nt
CTTTCCTTTTTGCTGGTAGGGCCGGGTGGTTGCTGCCGAAATGGGCAAGTTCATGAAACCTGGGAAGGTGGTGCTTGTCCTGGCTGGACG
CTACTCCGGACGCAAAGCTGTCATCGTGAAGAACATTGATGATGGCACCTCAGATCGCCCCTACAGCCATGCTCTGGTGGCTGGAATTGA
CCGCTACCCCCGCAAAGTGACAGCTGCCATGGGCAAGAAGAAGATCGCCAAGAGATCAAAGATAAAATCTTTTGTGAAAGTGTATAACTA
CAATCACCTAATGCCCACAAGCCAATAATTTCTGAAGATCAGACAGCAGCCCTGATGGCCCATCTCTTTGAAATGGGATTCTGTGACAGG

>76349_76349_2_RPL27-NBR1_RPL27_chr17_41152119_ENST00000253788_NBR1_chr17_41361920_ENST00000542611_length(amino acids)=85AA_BP=

--------------------------------------------------------------
>76349_76349_3_RPL27-NBR1_RPL27_chr17_41152119_ENST00000589037_NBR1_chr17_41361920_ENST00000341165_length(transcript)=2185nt_BP=396nt
ATTCGAATACTTGAGCTGCCGCGCCCTGCGTTTCCCTCATGAGCTTCTTCCGCCCGCAACACGAGACTCAGCACCACACAATCAGCGTGG
CAAAGCCTGAAGGGCGGGACAGGAAGTGAGGTCACTCCTCACCGGGGTGAAAGAAATGGGCAAGTTCATGAAACCTGGGAAGGTGGTGCT
TGTCCTGGCTGGACGCTACTCCGGACGCAAAGCTGTCATCGTGAAGAACATTGATGATGGCACCTCAGATCGCCCCTACAGCCATGCTCT
GGTGGCTGGAATTGACCGCTACCCCCGCAAAGTGACAGCTGCCATGGGCAAGAAGAAGATCGCCAAGAGATCAAAGATAAAATCTTTTGT
GAAAGTGTATAACTACAATCACCTAATGCCCACAAGCCAATAATTTCTGAAGATCAGACAGCAGCCCTGATGGCCCATCTCTTTGAAATG
GGATTCTGTGACAGGCAGCTGAACCTACGGCTGCTGAAGAAACACAATTACAATATCCTGCAGGTTGTGACAGAACTTCTTCAGTTAAAC
AACAACGACTGGTACAGCCAACGCTATTGAGGAGTGACCTTGTATTAAATAACTGCCTGCTGCTCAGAGATGATCTTTATTCTGTCATTG
GGGTATGGGATAGAAGCCCTTGCTTATTTTTAATCTGATGAATCTGTATAGAGCCCATCGTTGAGTTACCAAGACAATACCTGCTACAGT
ATTTTGGGGAGCAAACTAAAGACCAGAACTTAAATTTTCACTTTAGACATTGGATGAATAGTATGAAGACAGTTTTTCAGTTGATTTGGA
TAAAACTATTTTAGTGCATTGACAAGTGTAACTTCAACTTCATATAGAACCATTTTTCTTTCTGCTTTTATTGAAACTGAGTATTTTTCT
TTGGCTAATGTGGATTTTTTATGGGGATATCTGTTAATTTTCAGGTTTTGAAAGACATTAACCTCGGAAGTTGTTTTTAAGAATTATTCT
CATAATTCTTATTCTCATAATTTCTGTAATCCACCTCAAGCTTCATAGTTATTTGGCATTGAAATAACACCCAGAGCATGATAGAAATGT
TGTTACTCTTCCTCTCTCAAGGAGAAAGTAATTTTCCTGCAATACTTAATAATTGGCACCGTTGCTTTCTAAAGACTCCATGGTGCATTC
AAGAGTATCCAACTTCAAGGGAATCTCCGCATTTCAATGAAAGGAGGAAGAGTGTGCTGATAAACCTACCAGCACCTATTGAGCAATGTC
TATTATAGTAATTTTGCATACATTTTTATTTAAGGGAAAAAATATAGGTATTGTGAAATATTTTGCTAATCTTATAGAAAAGGAAAAAAT
CCCGTTATTTAAAGGGAAAAGTAAATTTAACAGTTGCCTTTTTTCTTAATGTCAGGGCAGATCTTATTTTACAGTACAGTGGGGGAAATA
GAAACATGTGAAAGGCAAAAGGCAGGCTCCTAAATTAATGTCAGTGAAGTTCAGGGTGGGCAAATGAGTGTGTGTGAGGTATAGGAAATG
CTGATGACTTCTTTAATGCTTGAAGTCCGTTCACAGGTATCTAGCCCTAGAATGCCTAGAACAGGAAGAGGCAGCTGGTGTTCTGCAAAA
CTTGGACAGGGGCAAAGTTGCTGAAAAAGTTTTGGTTTAACCCGAAGATAAGTGGAAAAGAGCTTGTCCATGAACCCAGGTTCTCACTCT
GTTTACAGAAGTGTGTTGAGTACAGTTGGTGAAGGAAGAGGTAACAAAAAATGCTAAATATTTTATCCATGAAAATGACTTCCAGAAAAG
GAAGAATATGAACCCCAGACCGAAGGGGAAAAGATAGTTAATAGTATTATCTAACCTGGTTGGTATTTGTAATGAATGGTGATTTTAATT
AGTCATTAGCCATAATGATGTTTATTTACAGTATAACTCCTGAATGCTACTTAAATAAACCAGGATTCAAACTGCAAGCCAGCCAGGCCG
TTCATTATTTAAAACGTTTTAATCGGGGCTTCCGGGTAGAAGGTGGAGCGGCAGGGTGTAATTGGGTTGATGGGTGGGACCTGTCTTGAC
CATCGGAGTTTTATAATCGAGGGCCAGGAGGGCCCGGGTTGCTCTCCTGGTTATGTATGTACTTGTACATAACCACCTAAAGAATGGTGA

>76349_76349_3_RPL27-NBR1_RPL27_chr17_41152119_ENST00000589037_NBR1_chr17_41361920_ENST00000341165_length(amino acids)=85AA_BP=

--------------------------------------------------------------
>76349_76349_4_RPL27-NBR1_RPL27_chr17_41152119_ENST00000589037_NBR1_chr17_41361920_ENST00000542611_length(transcript)=489nt_BP=396nt
ATTCGAATACTTGAGCTGCCGCGCCCTGCGTTTCCCTCATGAGCTTCTTCCGCCCGCAACACGAGACTCAGCACCACACAATCAGCGTGG
CAAAGCCTGAAGGGCGGGACAGGAAGTGAGGTCACTCCTCACCGGGGTGAAAGAAATGGGCAAGTTCATGAAACCTGGGAAGGTGGTGCT
TGTCCTGGCTGGACGCTACTCCGGACGCAAAGCTGTCATCGTGAAGAACATTGATGATGGCACCTCAGATCGCCCCTACAGCCATGCTCT
GGTGGCTGGAATTGACCGCTACCCCCGCAAAGTGACAGCTGCCATGGGCAAGAAGAAGATCGCCAAGAGATCAAAGATAAAATCTTTTGT
GAAAGTGTATAACTACAATCACCTAATGCCCACAAGCCAATAATTTCTGAAGATCAGACAGCAGCCCTGATGGCCCATCTCTTTGAAATG

>76349_76349_4_RPL27-NBR1_RPL27_chr17_41152119_ENST00000589037_NBR1_chr17_41361920_ENST00000542611_length(amino acids)=85AA_BP=

--------------------------------------------------------------
>76349_76349_5_RPL27-NBR1_RPL27_chr17_41152119_ENST00000589913_NBR1_chr17_41361920_ENST00000341165_length(transcript)=2314nt_BP=525nt
TAGAAGCTTGGGTTGAATCTTTCAATCCGCTGCCATCCGCGGCTTGGGGGTCGAAGGTCCGGGCGGCGCCGGGTGCATTCCTTCCCTAGG
TCTCTGGCGGCTACGTATCCGATCCTGTCCTGCGAGCAGGGCCCTCGGGCGGCCTTGACCAAGGCGACAGTGAACACAGTCTGAAGTTCC
GGCCCAAGACCTGGGCTTGCTGGCAGGAGTCAGCTCTGGGCATCTTTGGCTTTACGGATTTTTAAGTGGCCCTTTCTCCTTGCTCTCTGC
AGAAATGGGCAAGTTCATGAAACCTGGGAAGGTGGTGCTTGTCCTGGCTGGACGCTACTCCGGACGCAAAGCTGTCATCGTGAAGAACAT
TGATGATGGCACCTCAGATCGCCCCTACAGCCATGCTCTGGTGGCTGGAATTGACCGCTACCCCCGCAAAGTGACAGCTGCCATGGGCAA
GAAGAAGATCGCCAAGAGATCAAAGATAAAATCTTTTGTGAAAGTGTATAACTACAATCACCTAATGCCCACAAGCCAATAATTTCTGAA
GATCAGACAGCAGCCCTGATGGCCCATCTCTTTGAAATGGGATTCTGTGACAGGCAGCTGAACCTACGGCTGCTGAAGAAACACAATTAC
AATATCCTGCAGGTTGTGACAGAACTTCTTCAGTTAAACAACAACGACTGGTACAGCCAACGCTATTGAGGAGTGACCTTGTATTAAATA
ACTGCCTGCTGCTCAGAGATGATCTTTATTCTGTCATTGGGGTATGGGATAGAAGCCCTTGCTTATTTTTAATCTGATGAATCTGTATAG
AGCCCATCGTTGAGTTACCAAGACAATACCTGCTACAGTATTTTGGGGAGCAAACTAAAGACCAGAACTTAAATTTTCACTTTAGACATT
GGATGAATAGTATGAAGACAGTTTTTCAGTTGATTTGGATAAAACTATTTTAGTGCATTGACAAGTGTAACTTCAACTTCATATAGAACC
ATTTTTCTTTCTGCTTTTATTGAAACTGAGTATTTTTCTTTGGCTAATGTGGATTTTTTATGGGGATATCTGTTAATTTTCAGGTTTTGA
AAGACATTAACCTCGGAAGTTGTTTTTAAGAATTATTCTCATAATTCTTATTCTCATAATTTCTGTAATCCACCTCAAGCTTCATAGTTA
TTTGGCATTGAAATAACACCCAGAGCATGATAGAAATGTTGTTACTCTTCCTCTCTCAAGGAGAAAGTAATTTTCCTGCAATACTTAATA
ATTGGCACCGTTGCTTTCTAAAGACTCCATGGTGCATTCAAGAGTATCCAACTTCAAGGGAATCTCCGCATTTCAATGAAAGGAGGAAGA
GTGTGCTGATAAACCTACCAGCACCTATTGAGCAATGTCTATTATAGTAATTTTGCATACATTTTTATTTAAGGGAAAAAATATAGGTAT
TGTGAAATATTTTGCTAATCTTATAGAAAAGGAAAAAATCCCGTTATTTAAAGGGAAAAGTAAATTTAACAGTTGCCTTTTTTCTTAATG
TCAGGGCAGATCTTATTTTACAGTACAGTGGGGGAAATAGAAACATGTGAAAGGCAAAAGGCAGGCTCCTAAATTAATGTCAGTGAAGTT
CAGGGTGGGCAAATGAGTGTGTGTGAGGTATAGGAAATGCTGATGACTTCTTTAATGCTTGAAGTCCGTTCACAGGTATCTAGCCCTAGA
ATGCCTAGAACAGGAAGAGGCAGCTGGTGTTCTGCAAAACTTGGACAGGGGCAAAGTTGCTGAAAAAGTTTTGGTTTAACCCGAAGATAA
GTGGAAAAGAGCTTGTCCATGAACCCAGGTTCTCACTCTGTTTACAGAAGTGTGTTGAGTACAGTTGGTGAAGGAAGAGGTAACAAAAAA
TGCTAAATATTTTATCCATGAAAATGACTTCCAGAAAAGGAAGAATATGAACCCCAGACCGAAGGGGAAAAGATAGTTAATAGTATTATC
TAACCTGGTTGGTATTTGTAATGAATGGTGATTTTAATTAGTCATTAGCCATAATGATGTTTATTTACAGTATAACTCCTGAATGCTACT
TAAATAAACCAGGATTCAAACTGCAAGCCAGCCAGGCCGTTCATTATTTAAAACGTTTTAATCGGGGCTTCCGGGTAGAAGGTGGAGCGG
CAGGGTGTAATTGGGTTGATGGGTGGGACCTGTCTTGACCATCGGAGTTTTATAATCGAGGGCCAGGAGGGCCCGGGTTGCTCTCCTGGT

>76349_76349_5_RPL27-NBR1_RPL27_chr17_41152119_ENST00000589913_NBR1_chr17_41361920_ENST00000341165_length(amino acids)=113AA_BP=
MGLLAGVSSGHLWLYGFLSGPFSLLSAEMGKFMKPGKVVLVLAGRYSGRKAVIVKNIDDGTSDRPYSHALVAGIDRYPRKVTAAMGKKKI

--------------------------------------------------------------
>76349_76349_6_RPL27-NBR1_RPL27_chr17_41152119_ENST00000589913_NBR1_chr17_41361920_ENST00000542611_length(transcript)=618nt_BP=525nt
TAGAAGCTTGGGTTGAATCTTTCAATCCGCTGCCATCCGCGGCTTGGGGGTCGAAGGTCCGGGCGGCGCCGGGTGCATTCCTTCCCTAGG
TCTCTGGCGGCTACGTATCCGATCCTGTCCTGCGAGCAGGGCCCTCGGGCGGCCTTGACCAAGGCGACAGTGAACACAGTCTGAAGTTCC
GGCCCAAGACCTGGGCTTGCTGGCAGGAGTCAGCTCTGGGCATCTTTGGCTTTACGGATTTTTAAGTGGCCCTTTCTCCTTGCTCTCTGC
AGAAATGGGCAAGTTCATGAAACCTGGGAAGGTGGTGCTTGTCCTGGCTGGACGCTACTCCGGACGCAAAGCTGTCATCGTGAAGAACAT
TGATGATGGCACCTCAGATCGCCCCTACAGCCATGCTCTGGTGGCTGGAATTGACCGCTACCCCCGCAAAGTGACAGCTGCCATGGGCAA
GAAGAAGATCGCCAAGAGATCAAAGATAAAATCTTTTGTGAAAGTGTATAACTACAATCACCTAATGCCCACAAGCCAATAATTTCTGAA

>76349_76349_6_RPL27-NBR1_RPL27_chr17_41152119_ENST00000589913_NBR1_chr17_41361920_ENST00000542611_length(amino acids)=113AA_BP=
MGLLAGVSSGHLWLYGFLSGPFSLLSAEMGKFMKPGKVVLVLAGRYSGRKAVIVKNIDDGTSDRPYSHALVAGIDRYPRKVTAAMGKKKI

--------------------------------------------------------------
>76349_76349_7_RPL27-NBR1_RPL27_chr17_41152119_ENST00000590864_NBR1_chr17_41361920_ENST00000341165_length(transcript)=2170nt_BP=381nt
TCTAGTAAGCCGTTCCAGATGCTTCCTGATGGAGATAAACACTGTTCTGTTTCTCTTTGGTCATTTCTCATAGCTTTCTGTGATTTTTCT
CTTTATAATGGTGGATCTTGGAGACCTGAGGGTGGAAATATTTTTTGGACACTGCACTACCTCTAACACAGGGCCTAAATAGGCCCTCAG
TGAATAACAAATGTAATTCTTACTCATTTAGAACATTGATGATGGCACCTCAGATCGCCCCTACAGCCATGCTCTGGTGGCTGGAATTGA
CCGCTACCCCCGCAAAGTGACAGCTGCCATGGGCAAGAAGAAGATCGCCAAGAGATCAAAGATAAAATCTTTTGTGAAAGTGTATAACTA
CAATCACCTAATGCCCACAAGCCAATAATTTCTGAAGATCAGACAGCAGCCCTGATGGCCCATCTCTTTGAAATGGGATTCTGTGACAGG
CAGCTGAACCTACGGCTGCTGAAGAAACACAATTACAATATCCTGCAGGTTGTGACAGAACTTCTTCAGTTAAACAACAACGACTGGTAC
AGCCAACGCTATTGAGGAGTGACCTTGTATTAAATAACTGCCTGCTGCTCAGAGATGATCTTTATTCTGTCATTGGGGTATGGGATAGAA
GCCCTTGCTTATTTTTAATCTGATGAATCTGTATAGAGCCCATCGTTGAGTTACCAAGACAATACCTGCTACAGTATTTTGGGGAGCAAA
CTAAAGACCAGAACTTAAATTTTCACTTTAGACATTGGATGAATAGTATGAAGACAGTTTTTCAGTTGATTTGGATAAAACTATTTTAGT
GCATTGACAAGTGTAACTTCAACTTCATATAGAACCATTTTTCTTTCTGCTTTTATTGAAACTGAGTATTTTTCTTTGGCTAATGTGGAT
TTTTTATGGGGATATCTGTTAATTTTCAGGTTTTGAAAGACATTAACCTCGGAAGTTGTTTTTAAGAATTATTCTCATAATTCTTATTCT
CATAATTTCTGTAATCCACCTCAAGCTTCATAGTTATTTGGCATTGAAATAACACCCAGAGCATGATAGAAATGTTGTTACTCTTCCTCT
CTCAAGGAGAAAGTAATTTTCCTGCAATACTTAATAATTGGCACCGTTGCTTTCTAAAGACTCCATGGTGCATTCAAGAGTATCCAACTT
CAAGGGAATCTCCGCATTTCAATGAAAGGAGGAAGAGTGTGCTGATAAACCTACCAGCACCTATTGAGCAATGTCTATTATAGTAATTTT
GCATACATTTTTATTTAAGGGAAAAAATATAGGTATTGTGAAATATTTTGCTAATCTTATAGAAAAGGAAAAAATCCCGTTATTTAAAGG
GAAAAGTAAATTTAACAGTTGCCTTTTTTCTTAATGTCAGGGCAGATCTTATTTTACAGTACAGTGGGGGAAATAGAAACATGTGAAAGG
CAAAAGGCAGGCTCCTAAATTAATGTCAGTGAAGTTCAGGGTGGGCAAATGAGTGTGTGTGAGGTATAGGAAATGCTGATGACTTCTTTA
ATGCTTGAAGTCCGTTCACAGGTATCTAGCCCTAGAATGCCTAGAACAGGAAGAGGCAGCTGGTGTTCTGCAAAACTTGGACAGGGGCAA
AGTTGCTGAAAAAGTTTTGGTTTAACCCGAAGATAAGTGGAAAAGAGCTTGTCCATGAACCCAGGTTCTCACTCTGTTTACAGAAGTGTG
TTGAGTACAGTTGGTGAAGGAAGAGGTAACAAAAAATGCTAAATATTTTATCCATGAAAATGACTTCCAGAAAAGGAAGAATATGAACCC
CAGACCGAAGGGGAAAAGATAGTTAATAGTATTATCTAACCTGGTTGGTATTTGTAATGAATGGTGATTTTAATTAGTCATTAGCCATAA
TGATGTTTATTTACAGTATAACTCCTGAATGCTACTTAAATAAACCAGGATTCAAACTGCAAGCCAGCCAGGCCGTTCATTATTTAAAAC
GTTTTAATCGGGGCTTCCGGGTAGAAGGTGGAGCGGCAGGGTGTAATTGGGTTGATGGGTGGGACCTGTCTTGACCATCGGAGTTTTATA
ATCGAGGGCCAGGAGGGCCCGGGTTGCTCTCCTGGTTATGTATGTACTTGTACATAACCACCTAAAGAATGGTGAAATAAATGTTCTTGG

>76349_76349_7_RPL27-NBR1_RPL27_chr17_41152119_ENST00000590864_NBR1_chr17_41361920_ENST00000341165_length(amino acids)=74AA_BP=1

--------------------------------------------------------------
>76349_76349_8_RPL27-NBR1_RPL27_chr17_41152119_ENST00000590864_NBR1_chr17_41361920_ENST00000542611_length(transcript)=474nt_BP=381nt
TCTAGTAAGCCGTTCCAGATGCTTCCTGATGGAGATAAACACTGTTCTGTTTCTCTTTGGTCATTTCTCATAGCTTTCTGTGATTTTTCT
CTTTATAATGGTGGATCTTGGAGACCTGAGGGTGGAAATATTTTTTGGACACTGCACTACCTCTAACACAGGGCCTAAATAGGCCCTCAG
TGAATAACAAATGTAATTCTTACTCATTTAGAACATTGATGATGGCACCTCAGATCGCCCCTACAGCCATGCTCTGGTGGCTGGAATTGA
CCGCTACCCCCGCAAAGTGACAGCTGCCATGGGCAAGAAGAAGATCGCCAAGAGATCAAAGATAAAATCTTTTGTGAAAGTGTATAACTA
CAATCACCTAATGCCCACAAGCCAATAATTTCTGAAGATCAGACAGCAGCCCTGATGGCCCATCTCTTTGAAATGGGATTCTGTGACAGG

>76349_76349_8_RPL27-NBR1_RPL27_chr17_41152119_ENST00000590864_NBR1_chr17_41361920_ENST00000542611_length(amino acids)=58AA_BP=

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RPL27-NBR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RPL27-NBR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RPL27-NBR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource