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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:RPL28-ASB2 (FusionGDB2 ID:76364)

Fusion Gene Summary for RPL28-ASB2

Fusion gene summary

Fusion gene information	Fusion gene name: RPL28-ASB2
	Fusion gene ID: 76364
		Hgene	Tgene
	Gene symbol	RPL28	ASB2
	Gene ID	6158	51676
	Gene name	ribosomal protein L28	ankyrin repeat and SOCS box containing 2
	Synonyms	L28	ASB-2
	Cytomap	19q13.42	14q32.12
	Type of gene	protein-coding	protein-coding
	Description	60S ribosomal protein L28large ribosomal subunit protein eL28	ankyrin repeat and SOCS box protein 2ankyrin repeat and SOCS box-containing protein 2a
	Modification date	20200313	20200313
	UniProtAcc	.	Q96Q27
	Ensembl transtripts involved in fusion gene	ENST00000344063, ENST00000458349, ENST00000558815, ENST00000428193, ENST00000431533, ENST00000558131, ENST00000558752, ENST00000559463, ENST00000560055, ENST00000560583,	ENST00000315988, ENST00000555019, ENST00000556337,
Fusion gene scores	* DoF score	22 X 17 X 5=1870	2 X 2 X 2=8
	# samples	24	2
	** MAII score	log2(24/1870*10)=-2.96193195916648 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: RPL28 [Title/Abstract] AND ASB2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RPL28(55902973)-ASB2(94413822), # samples:2
Anticipated loss of major functional domain due to fusion event.	RPL28-ASB2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. RPL28-ASB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ASB2	GO:0016567	protein ubiquitination	16325183

Fusion gene breakpoints across RPL28 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ASB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	EC567947	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
ChiTaRS5.0	N/A	EC582699	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-

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Fusion Gene ORF analysis for RPL28-ASB2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000344063	ENST00000315988	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
3UTR-3CDS	ENST00000344063	ENST00000555019	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
3UTR-intron	ENST00000344063	ENST00000556337	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
5CDS-intron	ENST00000458349	ENST00000556337	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
5CDS-intron	ENST00000558815	ENST00000556337	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
Frame-shift	ENST00000458349	ENST00000315988	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
Frame-shift	ENST00000458349	ENST00000555019	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
In-frame	ENST00000558815	ENST00000315988	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
In-frame	ENST00000558815	ENST00000555019	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
intron-3CDS	ENST00000428193	ENST00000315988	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
intron-3CDS	ENST00000428193	ENST00000555019	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
intron-3CDS	ENST00000431533	ENST00000315988	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
intron-3CDS	ENST00000431533	ENST00000555019	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
intron-3CDS	ENST00000558131	ENST00000315988	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
intron-3CDS	ENST00000558131	ENST00000555019	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
intron-3CDS	ENST00000558752	ENST00000315988	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
intron-3CDS	ENST00000558752	ENST00000555019	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
intron-3CDS	ENST00000559463	ENST00000315988	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
intron-3CDS	ENST00000559463	ENST00000555019	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
intron-3CDS	ENST00000560055	ENST00000315988	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
intron-3CDS	ENST00000560055	ENST00000555019	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
intron-3CDS	ENST00000560583	ENST00000315988	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
intron-3CDS	ENST00000560583	ENST00000555019	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
intron-intron	ENST00000428193	ENST00000556337	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
intron-intron	ENST00000431533	ENST00000556337	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
intron-intron	ENST00000558131	ENST00000556337	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
intron-intron	ENST00000558752	ENST00000556337	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
intron-intron	ENST00000559463	ENST00000556337	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
intron-intron	ENST00000560055	ENST00000556337	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-
intron-intron	ENST00000560583	ENST00000556337	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000558815	RPL28	chr19	55902973	-	ENST00000555019	ASB2	chr14	94413822	-	2051	564	1332	2048	239
ENST00000558815	RPL28	chr19	55902973	-	ENST00000315988	ASB2	chr14	94413822	-	2038	564	1319	2035	239

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000558815	ENST00000555019	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-	0.051370762	0.94862926
ENST00000558815	ENST00000315988	RPL28	chr19	55902973	-	ASB2	chr14	94413822	-	0.052899532	0.94710046

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Fusion Genomic Features for RPL28-ASB2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RPL28-ASB2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:55902973/chr14:94413822)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ASB2 Q96Q27
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269\|PubMed:15590664, ECO:0000269\|PubMed:16325183}.; FUNCTION: [Isoform 1]: Enhances adhesion of hematopoietic cells to fibronectin through targeting of filamins FLNA and FLNB for proteasomal degradation, it is transiantly expressed during hematopoietic cell differentiation. {ECO:0000269\|PubMed:21737450, ECO:0000269\|PubMed:24052262}.; FUNCTION: [Isoform 2]: Involved in myogenic differentiation and targets filamin FLNB for proteasomal degradation but not filamin FLNA. {ECO:0000269\|PubMed:19300455}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ASB2

chr19:55902973

chr14:94413822

ENST00000315988

533_587

588.0

Domain

SOCS box

Tgene

ASB2

chr19:55902973

chr14:94413822

ENST00000555019

533_587

636.0

Domain

SOCS box

Tgene

ASB2

chr19:55902973

chr14:94413822

ENST00000315988

123_152

588.0

Repeat

Note=ANK 3

Tgene

ASB2

chr19:55902973

chr14:94413822

ENST00000315988

156_185

588.0

Repeat

Note=ANK 4

Tgene

ASB2

chr19:55902973

chr14:94413822

ENST00000315988

189_218

588.0

Repeat

Note=ANK 5

Tgene

ASB2

chr19:55902973

chr14:94413822

ENST00000315988

222_251

588.0

Repeat

Note=ANK 6

Tgene

ASB2

chr19:55902973

chr14:94413822

ENST00000315988

255_284

588.0

Repeat

Note=ANK 7

Tgene

ASB2

chr19:55902973

chr14:94413822

ENST00000315988

288_317

588.0

Repeat

Note=ANK 8

Tgene

ASB2

chr19:55902973

chr14:94413822

ENST00000315988

320_349

588.0

Repeat

Note=ANK 9

Tgene

ASB2

chr19:55902973

chr14:94413822

ENST00000315988

362_391

588.0

Repeat

Note=ANK 10

Tgene

ASB2

chr19:55902973

chr14:94413822

ENST00000315988

392_421

588.0

Repeat

Note=ANK 11

Tgene

ASB2

chr19:55902973

chr14:94413822

ENST00000315988

428_456

588.0

Repeat

Note=ANK 12

Tgene

ASB2

chr19:55902973

chr14:94413822

ENST00000315988

56_85

588.0

Repeat

Note=ANK 1

Tgene

ASB2

chr19:55902973

chr14:94413822

ENST00000315988

89_119

588.0

Repeat

Note=ANK 2

Tgene

ASB2

chr19:55902973

chr14:94413822

ENST00000555019

123_152

636.0

Repeat

Note=ANK 3

Tgene

ASB2

chr19:55902973

chr14:94413822

ENST00000555019

156_185

636.0

Repeat

Note=ANK 4

Tgene

ASB2

chr19:55902973

chr14:94413822

ENST00000555019

189_218

636.0

Repeat

Note=ANK 5

Tgene

ASB2

chr19:55902973

chr14:94413822

ENST00000555019

222_251

636.0

Repeat

Note=ANK 6

Tgene

ASB2

chr19:55902973

chr14:94413822

ENST00000555019

255_284

636.0

Repeat

Note=ANK 7

Tgene

ASB2

chr19:55902973

chr14:94413822

ENST00000555019

288_317

636.0

Repeat

Note=ANK 8

Tgene

ASB2

chr19:55902973

chr14:94413822

ENST00000555019

320_349

636.0

Repeat

Note=ANK 9

Tgene

ASB2

chr19:55902973

chr14:94413822

ENST00000555019

362_391

636.0

Repeat

Note=ANK 10

Tgene

ASB2

chr19:55902973

chr14:94413822

ENST00000555019

392_421

636.0

Repeat

Note=ANK 11

Tgene

ASB2

chr19:55902973

chr14:94413822

ENST00000555019

428_456

636.0

Repeat

Note=ANK 12

Tgene

ASB2

chr19:55902973

chr14:94413822

ENST00000555019

56_85

636.0

Repeat

Note=ANK 1

Tgene

ASB2

chr19:55902973

chr14:94413822

ENST00000555019

89_119

636.0

Repeat

Note=ANK 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for RPL28-ASB2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>76364_76364_1_RPL28-ASB2_RPL28_chr19_55902973_ENST00000558815_ASB2_chr14_94413822_ENST00000315988_length(transcript)=2038nt_BP=564nt
CTCTTTCCGTCTCAGGTCGCCGCTGCGAAGGGAGCCGCCGCCATGTCTGCGCATCTGCAATGGATGGTCGTGCGGAACTGCTCCAGTTTC
CTGATCAAGAGGAATAAGCAGACCTACAGCACTGAGCCCAATAACTTGAAGGCCCGCAATTCCTTCCGCTACAACGGACTGATTCACCGC
AAGACTGTGGGCGTGGAGCCGGCAGCCGACGGCAAAGGTGTCGTGGTGGTCATTAAGCGGAGATCCGGCCAGCGGAAGCCTGCCACCTCC
TATGTGCGGACCACCATCAACAAGAATGCTCGCGCCACGCTCAGCAGCATCAGACACATGATCCGCAAGAACAAGTACCGCCCCGACCTG
CGCATGCTTGGGCAAGTTCCTCAACCTCTCTGTGTCTTCGTACCCTCATCTGTAACATGCGTGTCGATAGACCCTACTACTCAGGGTTGA
TGAGAAGATTAAATGTGCAAAACCTGCTTGACTGTGCCCACAAATCCTGATTGTAGGAATAAATTAATGACTTTTTATAAATATTTTGAT
CAGATGGACTCATGATCACAGATGAACCTCCAAGACCTCTGGCTCACCTTTGCCGACTGCGGGTTCGAAAGGCCATTGGGAAATACCGTA
TAAAACTCCTAGACACCTTGCCGCTCCCAGGCAGGCTGATTAGATACCTGAAATACGAGAACACCCAGTAACTGGGGCCACGGGGAGAGA
GGAGTAGCCCCTCAGACTCTTCTTACTAAGTCTCAGGACGTCGGTGTTCCCAACTCCAAGGGGACCTGGTGACAGACGAGGCTGCAGGCT
GCCTCCCTCTCAGCCTGGACAGCTACCAGGATCTCACTGGGTCTCAGGGCCCAGAGCTTTGGCCAGAGCAGAGAACAGAATGTGTCAAGG
AGAAGAATCATTTGTTTACAAACTGATGAGCAGATCCCAGACCTTCTCTACCTTCAGGAATGGCAGAAACCTCTATTCCTGGGGCCAGGG
CAGAGCTTGAGGTGTTCTGGGGAAGGTGGTGCTCAGAGCCTTCCCTGTGCCCCTCCACTTGTTCTGGAAAACTCACCACTTGACTTCAGA
GCTTTCTCTCCAAAGACTAAGATGAAGACGTGGCCCAAGGTAGGGGGTAGGGGGAGCCTGGGTCTTGGAGGGCTTTGTTAAGTATTAATA
TAATAAATGTTACACATGTGATTCTGTGAGTTCGTATCTGCCCCAGAGGTGAGCCGCTGGGCGGGGCCCATCATCGATGTCCTCCTGGAC
TACGTGGGCAACGTGCAGCTCTGCTCGCGGCTGAAGGAACACATCGACAGCTTTGAGGACTGGGCCGTCATCAAGGAGAAGGCAGGATCG
TGCAGATGCTGCTGCCGGTGACCAGCCGCACGCGCATACGCCGTAGCGGCGTCAGTCCGCTGCACCTGGCGGCCGAGCGCAACCACGACG
AGGTGCTGGAGGCGCTGCTGAGCGCGCGCTTCGACGTGAACACGCCGCTGGCCCCCGAGCGCGCGCGCCTCTACGAAGACCGGCGCAGCT
CCGCGCTGTACTTCGCGGTGGTCAACAACAACGTGTACGCCACCGAGCTGCTGCTGCAACACGGCGCCGACCCCAACCGCGACGTCATCA
GCCCCTTGCTCGTGGCCATCCGCCACGGCTGCCTGCGCACAATGCAGCTGCTGCTGGACCACGGCGCGAACATCGACGCCTATATCGCCA
CGCACCCCACCGCCTTCCCCGCCACCATCATGTTCGCCATGAAGTGCCTGTCGCTGCTCAAGTTCCTCATGGACCTGGGCTGCGACGGCG
AGCCCTGCTTCTCATGCCTCTACGGCAACGGCCCGCACCCGCCGGCCCCGCAGCCCTCCAGCAGGTTCAACGACGCGCCCGCGGCCGACA
AGGAGCCCAGCGTGGTGCAGTACGAGGCCTGCAAGAATGAGCATGAGGAGGTGGTGGAGTTTCTGCTGTCACAGGGTGCCGACGCCAACA

>76364_76364_1_RPL28-ASB2_RPL28_chr19_55902973_ENST00000558815_ASB2_chr14_94413822_ENST00000315988_length(amino acids)=239AA_BP=197
MGRHQGEGRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQ
HGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPQPS

--------------------------------------------------------------
>76364_76364_2_RPL28-ASB2_RPL28_chr19_55902973_ENST00000558815_ASB2_chr14_94413822_ENST00000555019_length(transcript)=2051nt_BP=564nt
CTCTTTCCGTCTCAGGTCGCCGCTGCGAAGGGAGCCGCCGCCATGTCTGCGCATCTGCAATGGATGGTCGTGCGGAACTGCTCCAGTTTC
CTGATCAAGAGGAATAAGCAGACCTACAGCACTGAGCCCAATAACTTGAAGGCCCGCAATTCCTTCCGCTACAACGGACTGATTCACCGC
AAGACTGTGGGCGTGGAGCCGGCAGCCGACGGCAAAGGTGTCGTGGTGGTCATTAAGCGGAGATCCGGCCAGCGGAAGCCTGCCACCTCC
TATGTGCGGACCACCATCAACAAGAATGCTCGCGCCACGCTCAGCAGCATCAGACACATGATCCGCAAGAACAAGTACCGCCCCGACCTG
CGCATGCTTGGGCAAGTTCCTCAACCTCTCTGTGTCTTCGTACCCTCATCTGTAACATGCGTGTCGATAGACCCTACTACTCAGGGTTGA
TGAGAAGATTAAATGTGCAAAACCTGCTTGACTGTGCCCACAAATCCTGATTGTAGGAATAAATTAATGACTTTTTATAAATATTTTGAT
CAGATGGACTCATGATCACAGATGAACCTCCAAGACCTCTGGCTCACCTTTGCCGACTGCGGGTTCGAAAGGCCATTGGGAAATACCGTA
TAAAACTCCTAGACACCTTGCCGCTCCCAGGCAGGCTGATTAGATACCTGAAATACGAGAACACCCAGTAACTGGGGCCACGGGGAGAGA
GGAGTAGCCCCTCAGACTCTTCTTACTAAGTCTCAGGACGTCGGTGTTCCCAACTCCAAGGGGACCTGGTGACAGACGAGGCTGCAGGCT
GCCTCCCTCTCAGCCTGGACAGCTACCAGGATCTCACTGGGTCTCAGGGCCCAGAGCTTTGGCCAGAGCAGAGAACAGAATGTGTCAAGG
AGAAGAATCATTTGTTTACAAACTGATGAGCAGATCCCAGACCTTCTCTACCTTCAGGAATGGCAGAAACCTCTATTCCTGGGGCCAGGG
CAGAGCTTGAGGTGTTCTGGGGAAGGTGGTGCTCAGAGCCTTCCCTGTGCCCCTCCACTTGTTCTGGAAAACTCACCACTTGACTTCAGA
GCTTTCTCTCCAAAGACTAAGATGAAGACGTGGCCCAAGGTAGGGGGTAGGGGGAGCCTGGGTCTTGGAGGGCTTTGTTAAGTATTAATA
TAATAAATGTTACACATGTGACACCTGCCCAGTGTTCTGTGAGTTCGTATCTGCCCCAGAGGTGAGCCGCTGGGCGGGGCCCATCATCGA
TGTCCTCCTGGACTACGTGGGCAACGTGCAGCTCTGCTCGCGGCTGAAGGAACACATCGACAGCTTTGAGGACTGGGCCGTCATCAAGGA
GAAGGCAGGATCGTGCAGATGCTGCTGCCGGTGACCAGCCGCACGCGCATACGCCGTAGCGGCGTCAGTCCGCTGCACCTGGCGGCCGAG
CGCAACCACGACGAGGTGCTGGAGGCGCTGCTGAGCGCGCGCTTCGACGTGAACACGCCGCTGGCCCCCGAGCGCGCGCGCCTCTACGAA
GACCGGCGCAGCTCCGCGCTGTACTTCGCGGTGGTCAACAACAACGTGTACGCCACCGAGCTGCTGCTGCAACACGGCGCCGACCCCAAC
CGCGACGTCATCAGCCCCTTGCTCGTGGCCATCCGCCACGGCTGCCTGCGCACAATGCAGCTGCTGCTGGACCACGGCGCGAACATCGAC
GCCTATATCGCCACGCACCCCACCGCCTTCCCCGCCACCATCATGTTCGCCATGAAGTGCCTGTCGCTGCTCAAGTTCCTCATGGACCTG
GGCTGCGACGGCGAGCCCTGCTTCTCATGCCTCTACGGCAACGGCCCGCACCCGCCGGCCCCGCAGCCCTCCAGCAGGTTCAACGACGCG
CCCGCGGCCGACAAGGAGCCCAGCGTGGTGCAGTACGAGGCCTGCAAGAATGAGCATGAGGAGGTGGTGGAGTTTCTGCTGTCACAGGGT

>76364_76364_2_RPL28-ASB2_RPL28_chr19_55902973_ENST00000558815_ASB2_chr14_94413822_ENST00000555019_length(amino acids)=239AA_BP=197
MGRHQGEGRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQ
HGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPQPS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RPL28-ASB2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for RPL28-ASB2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for RPL28-ASB2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source