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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RPL28-GLB1 (FusionGDB2 ID:76372)

Fusion Gene Summary for RPL28-GLB1

check button Fusion gene summary
Fusion gene informationFusion gene name: RPL28-GLB1
Fusion gene ID: 76372
HgeneTgene
Gene symbol

RPL28

GLB1

Gene ID

6158

2720

Gene nameribosomal protein L28galactosidase beta 1
SynonymsL28EBP|ELNR1|MPS4B
Cytomap

19q13.42

3p22.3

Type of geneprotein-codingprotein-coding
Description60S ribosomal protein L28large ribosomal subunit protein eL28beta-galactosidaseacid beta-galactosidaseelastin binding proteinelastin receptor 1, 67kDalactase
Modification date2020031320200313
UniProtAcc.

Q8NCI6

Ensembl transtripts involved in fusion geneENST00000558131, ENST00000344063, 
ENST00000458349, ENST00000558815, 
ENST00000559463, ENST00000560055, 
ENST00000560583, ENST00000428193, 
ENST00000431533, ENST00000558752, 
ENST00000307363, ENST00000307377, 
ENST00000399402, ENST00000445488, 
ENST00000497796, 
Fusion gene scores* DoF score22 X 17 X 5=18709 X 9 X 5=405
# samples 249
** MAII scorelog2(24/1870*10)=-2.96193195916648
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/405*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPL28 [Title/Abstract] AND GLB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRPL28(55899416)-GLB1(33114206), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGLB1

GO:0044262

cellular carbohydrate metabolic process

11927518


check buttonFusion gene breakpoints across RPL28 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GLB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADA524376RPL28chr19

55899416

+GLB1chr3

33114206

-


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Fusion Gene ORF analysis for RPL28-GLB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000558131ENST00000307363RPL28chr19

55899416

+GLB1chr3

33114206

-
3UTR-5UTRENST00000558131ENST00000307377RPL28chr19

55899416

+GLB1chr3

33114206

-
3UTR-5UTRENST00000558131ENST00000399402RPL28chr19

55899416

+GLB1chr3

33114206

-
3UTR-5UTRENST00000558131ENST00000445488RPL28chr19

55899416

+GLB1chr3

33114206

-
3UTR-intronENST00000558131ENST00000497796RPL28chr19

55899416

+GLB1chr3

33114206

-
5CDS-5UTRENST00000344063ENST00000307377RPL28chr19

55899416

+GLB1chr3

33114206

-
5CDS-5UTRENST00000344063ENST00000399402RPL28chr19

55899416

+GLB1chr3

33114206

-
5CDS-5UTRENST00000344063ENST00000445488RPL28chr19

55899416

+GLB1chr3

33114206

-
5CDS-5UTRENST00000458349ENST00000307377RPL28chr19

55899416

+GLB1chr3

33114206

-
5CDS-5UTRENST00000458349ENST00000399402RPL28chr19

55899416

+GLB1chr3

33114206

-
5CDS-5UTRENST00000458349ENST00000445488RPL28chr19

55899416

+GLB1chr3

33114206

-
5CDS-5UTRENST00000558815ENST00000307377RPL28chr19

55899416

+GLB1chr3

33114206

-
5CDS-5UTRENST00000558815ENST00000399402RPL28chr19

55899416

+GLB1chr3

33114206

-
5CDS-5UTRENST00000558815ENST00000445488RPL28chr19

55899416

+GLB1chr3

33114206

-
5CDS-5UTRENST00000559463ENST00000307377RPL28chr19

55899416

+GLB1chr3

33114206

-
5CDS-5UTRENST00000559463ENST00000399402RPL28chr19

55899416

+GLB1chr3

33114206

-
5CDS-5UTRENST00000559463ENST00000445488RPL28chr19

55899416

+GLB1chr3

33114206

-
5CDS-5UTRENST00000560055ENST00000307377RPL28chr19

55899416

+GLB1chr3

33114206

-
5CDS-5UTRENST00000560055ENST00000399402RPL28chr19

55899416

+GLB1chr3

33114206

-
5CDS-5UTRENST00000560055ENST00000445488RPL28chr19

55899416

+GLB1chr3

33114206

-
5CDS-5UTRENST00000560583ENST00000307377RPL28chr19

55899416

+GLB1chr3

33114206

-
5CDS-5UTRENST00000560583ENST00000399402RPL28chr19

55899416

+GLB1chr3

33114206

-
5CDS-5UTRENST00000560583ENST00000445488RPL28chr19

55899416

+GLB1chr3

33114206

-
5CDS-intronENST00000344063ENST00000497796RPL28chr19

55899416

+GLB1chr3

33114206

-
5CDS-intronENST00000458349ENST00000497796RPL28chr19

55899416

+GLB1chr3

33114206

-
5CDS-intronENST00000558815ENST00000497796RPL28chr19

55899416

+GLB1chr3

33114206

-
5CDS-intronENST00000559463ENST00000497796RPL28chr19

55899416

+GLB1chr3

33114206

-
5CDS-intronENST00000560055ENST00000497796RPL28chr19

55899416

+GLB1chr3

33114206

-
5CDS-intronENST00000560583ENST00000497796RPL28chr19

55899416

+GLB1chr3

33114206

-
In-frameENST00000344063ENST00000307363RPL28chr19

55899416

+GLB1chr3

33114206

-
In-frameENST00000458349ENST00000307363RPL28chr19

55899416

+GLB1chr3

33114206

-
In-frameENST00000558815ENST00000307363RPL28chr19

55899416

+GLB1chr3

33114206

-
In-frameENST00000559463ENST00000307363RPL28chr19

55899416

+GLB1chr3

33114206

-
In-frameENST00000560055ENST00000307363RPL28chr19

55899416

+GLB1chr3

33114206

-
In-frameENST00000560583ENST00000307363RPL28chr19

55899416

+GLB1chr3

33114206

-
intron-3CDSENST00000428193ENST00000307363RPL28chr19

55899416

+GLB1chr3

33114206

-
intron-3CDSENST00000431533ENST00000307363RPL28chr19

55899416

+GLB1chr3

33114206

-
intron-3CDSENST00000558752ENST00000307363RPL28chr19

55899416

+GLB1chr3

33114206

-
intron-5UTRENST00000428193ENST00000307377RPL28chr19

55899416

+GLB1chr3

33114206

-
intron-5UTRENST00000428193ENST00000399402RPL28chr19

55899416

+GLB1chr3

33114206

-
intron-5UTRENST00000428193ENST00000445488RPL28chr19

55899416

+GLB1chr3

33114206

-
intron-5UTRENST00000431533ENST00000307377RPL28chr19

55899416

+GLB1chr3

33114206

-
intron-5UTRENST00000431533ENST00000399402RPL28chr19

55899416

+GLB1chr3

33114206

-
intron-5UTRENST00000431533ENST00000445488RPL28chr19

55899416

+GLB1chr3

33114206

-
intron-5UTRENST00000558752ENST00000307377RPL28chr19

55899416

+GLB1chr3

33114206

-
intron-5UTRENST00000558752ENST00000399402RPL28chr19

55899416

+GLB1chr3

33114206

-
intron-5UTRENST00000558752ENST00000445488RPL28chr19

55899416

+GLB1chr3

33114206

-
intron-intronENST00000428193ENST00000497796RPL28chr19

55899416

+GLB1chr3

33114206

-
intron-intronENST00000431533ENST00000497796RPL28chr19

55899416

+GLB1chr3

33114206

-
intron-intronENST00000558752ENST00000497796RPL28chr19

55899416

+GLB1chr3

33114206

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000344063RPL28chr1955899416+ENST00000307363GLB1chr333114206-33499534462911821
ENST00000558815RPL28chr1955899416+ENST00000307363GLB1chr333114206-2762366422324760
ENST00000560583RPL28chr1955899416+ENST00000307363GLB1chr333114206-3481108511003043647
ENST00000560055RPL28chr1955899416+ENST00000307363GLB1chr333114206-2758362382320760
ENST00000559463RPL28chr1955899416+ENST00000307363GLB1chr333114206-31177213972679760
ENST00000458349RPL28chr1955899416+ENST00000307363GLB1chr333114206-272032402282760

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000344063ENST00000307363RPL28chr1955899416+GLB1chr333114206-0.0012659710.99873406
ENST00000558815ENST00000307363RPL28chr1955899416+GLB1chr333114206-0.0010491210.99895084
ENST00000560583ENST00000307363RPL28chr1955899416+GLB1chr333114206-0.0017589950.99824095
ENST00000560055ENST00000307363RPL28chr1955899416+GLB1chr333114206-0.0010500320.99894994
ENST00000559463ENST00000307363RPL28chr1955899416+GLB1chr333114206-0.0009885730.9990114
ENST00000458349ENST00000307363RPL28chr1955899416+GLB1chr333114206-0.0010106430.9989894

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Fusion Genomic Features for RPL28-GLB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RPL28-GLB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:55899416/chr3:33114206)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GLB1

Q8NCI6

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for RPL28-GLB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>76372_76372_1_RPL28-GLB1_RPL28_chr19_55899416_ENST00000344063_GLB1_chr3_33114206_ENST00000307363_length(transcript)=3349nt_BP=953nt
GGGAGGGCGAACTGCAAGAGGGCTGCCAGGATTAGCCGAGGGATTCCGAATGAAGACGGAGTATTTCCGAACATACACACCTCTCCCAAG
AGCGTTTCCGGAGGGTTCCGAAAATACCCGAGCGGGCCTCGGCGCCCTCATTGGCCATCACCGCGAGGGCTTACGAAGACCGGAAATATC
CAAAGGTGCCGGGGCTAGGCTTATATAGTTCACGCATTCACCAGTTCATTCATAAAACAAATGTTTGTTGAGCGCCCATCATATGCCAAT
CACAGTGACAAGTGCTGGGTGAGCAATACTGGAGAGATAACGCTGAGGTATGGGTCCCAGGACCTCTCGAATTGGAGCCACTCGGAAATC
CAGCGGTAGAGTTTCGAAAACTTCCGAACGGTTCCCGGAATACGCTCTCGGCCCTCTAACCGAAGAGTTCCGAATATTCCCGAGCGTTGA
GCGAATTTTCGGCGGAAGCAGCCGAACATCATCGAGCCGCCTCGGAGGTGGGGACCGACAACTCCTGTCGTGCCCGCCCGGAGAGGAAGC
GGAAATGCGTGTACGGTATTAAAGGCGTCGCCTCGCCCCTCGCCTTCCTCTTTCCGTCTCAGGTCGCCGCTGCGAAGGGAGCCGCCGCCA
TGTCTGCGCATCTGCAATGGATGGTCGTGCGGAACTGCTCCAGTTTCCTGATCAAGAGGAATAAGCAGACCTACAGCACTGAGCCCAATA
ACTTGAAGGCCCGCAATTCCTTCCGCTACAACGGACTGATTCACCGCAAGACTGTGGGCGTGGAGCCGGCAGCCGACGGCAAAGGTGTCG
TGGTGGTCATTAAGCGGAGATCCGGCCAGCGGAAGCCTGCCACCTCCTATGTGCGGACCACCATCAACAAGAATGCTCGCGCCACGCTCA
GCAGCATCAGACACATGATCCGCAAGAACAAGTACCGCCCCGACCTGCGCATGAATGCCACCCAGAGGATGTTTGAAATTGACTATAGCC
GGGACTCCTTCCTCAAGGATGGCCAGCCATTTCGCTACATCTCAGGAAGCATTCACTACTCCCGTGTGCCCCGCTTCTACTGGAAGGACC
GGCTGCTGAAGATGAAGATGGCTGGGCTGAACGCCATCCAGACGTATGTGCCCTGGAACTTTCATGAGCCCTGGCCAGGACAGTACCAGT
TTTCTGAGGACCATGATGTGGAATATTTTCTTCGGCTGGCTCATGAGCTGGGACTGCTGGTTATCCTGAGGCCCGGGCCCTACATCTGTG
CAGAGTGGGAAATGGGAGGATTACCTGCTTGGCTGCTAGAGAAAGAGTCTATTCTTCTCCGCTCCTCCGACCCAGATTACCTGGCAGCTG
TGGACAAGTGGTTGGGAGTCCTTCTGCCCAAGATGAAGCCTCTCCTCTATCAGAATGGAGGGCCAGTTATAACAGTGCAGGTTGAAAATG
AATATGGCAGCTACTTTGCCTGTGATTTTGACTACCTGCGCTTCCTGCAGAAGCGCTTTCGCCACCATCTGGGGGATGATGTGGTTCTGT
TTACCACTGATGGAGCACATAAAACATTCCTGAAATGTGGGGCCCTGCAGGGCCTCTACACCACGGTGGACTTTGGAACAGGCAGCAACA
TCACAGATGCTTTCCTAAGCCAGAGGAAGTGTGAGCCCAAAGGACCCTTGATCAATTCTGAATTCTATACTGGCTGGCTAGATCACTGGG
GCCAACCTCACTCCACAATCAAGACCGAAGCAGTGGCTTCCTCCCTCTATGATATACTTGCCCGTGGGGCGAGTGTGAACTTGTACATGT
TTATAGGTGGGACCAATTTTGCCTATTGGAATGGGGCCAACTCACCCTATGCAGCACAGCCCACCAGCTACGACTATGATGCCCCACTGA
GTGAGGCTGGGGACCTCACTGAGAAGTATTTTGCTCTGCGAAACATCATCCAGAAGTTTGAAAAAGTACCAGAAGGTCCTATCCCTCCAT
CTACACCAAAGTTTGCATATGGAAAGGTCACTTTGGAAAAGTTAAAGACAGTGGGAGCAGCTCTGGACATTCTGTGTCCCTCTGGGCCCA
TCAAAAGCCTTTATCCCTTGACATTTATCCAGGTGAAACAGCATTATGGGTTTGTGCTGTACCGGACAACACTTCCTCAAGATTGCAGCA
ACCCAGCACCTCTCTCTTCACCCCTCAATGGAGTCCACGATCGAGCATATGTTGCTGTGGATGGGATCCCCCAGGGAGTCCTTGAGCGAA
ACAATGTGATCACTCTGAACATAACAGGGAAAGCTGGAGCCACTCTGGACCTTCTGGTAGAGAACATGGGACGTGTGAACTATGGTGCAT
ATATCAACGATTTTAAGGGTTTGGTTTCTAACCTGACTCTCAGTTCCAATATCCTCACGGACTGGACGATCTTTCCACTGGACACTGAGG
ATGCAGTGTGCAGCCACCTGGGGGGCTGGGGACACCGTGACAGTGGCCACCATGATGAAGCCTGGGCCCACAACTCATCCAACTACACGC
TCCCGGCCTTTTATATGGGGAACTTCTCCATTCCCAGTGGGATCCCAGACTTGCCCCAGGACACCTTTATCCAGTTTCCTGGATGGACCA
AGGGCCAGGTCTGGATTAATGGCTTTAACCTTGGCCGCTATTGGCCAGCCCGGGGCCCTCAGTTGACCTTGTTTGTGCCCCAGCACATCC
TGATGACCTCGGCCCCAAACACCATCACCGTGCTGGAACTGGAGTGGGCACCCTGCAGCAGTGATGATCCAGAACTATGTGCTGTGACGT
TCGTGGACAGGCCAGTTATTGGCTCATCTGTGACCTACGATCATCCCTCCAAACCTGTTGAAAAAAGACTCATGCCCCCACCCCCGCAAA
AAAACAAAGATTCATGGCTGGACCATGTATGATGATGAAAGCCTGTGTCTTTGAGGGATTCTACCCTGAACATACCTCACAGATCCTCCC
TGTCATGCCACATTTCACTGATTGGAATGTGGAAATGGAAAAGGAATTTAGGATGTGCATTTTCACCTGAGGTTTCCCTGCATCCCTGCA
GTGCCAAAGCCCCACCTTCAGGGACCACCTGGAATGTGTGAGGGGCTGACAGCACAGTAACGTGCATACATATCTGCAGGGCTGGAATGG
AAGCTTTAAAGGTGGTAGTGATTTTTATTTTGGAAGAATCATGTTACCTTTTTGTTAAATAAAATTTGTACTCAAATGATGATGTCACTG
TTTTTAATGTGCAGGTATTGAATTATATGGTCTGACTTAAATCATAACTAGACTTGAGTGGGCTGAATAAACCACTTCACTAACTTGAAG

>76372_76372_1_RPL28-GLB1_RPL28_chr19_55899416_ENST00000344063_GLB1_chr3_33114206_ENST00000307363_length(amino acids)=821AA_BP=169
MSEFSAEAAEHHRAASEVGTDNSCRARPERKRKCVYGIKGVASPLAFLFPSQVAAAKGAAAMSAHLQWMVVRNCSSFLIKRNKQTYSTEP
NNLKARNSFRYNGLIHRKTVGVEPAADGKGVVVVIKRRSGQRKPATSYVRTTINKNARATLSSIRHMIRKNKYRPDLRMNATQRMFEIDY
SRDSFLKDGQPFRYISGSIHYSRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPWPGQYQFSEDHDVEYFLRLAHELGLLVILRPGPYI
CAEWEMGGLPAWLLEKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPVITVQVENEYGSYFACDFDYLRFLQKRFRHHLGDDVV
LFTTDGAHKTFLKCGALQGLYTTVDFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDHWGQPHSTIKTEAVASSLYDILARGASVNLY
MFIGGTNFAYWNGANSPYAAQPTSYDYDAPLSEAGDLTEKYFALRNIIQKFEKVPEGPIPPSTPKFAYGKVTLEKLKTVGAALDILCPSG
PIKSLYPLTFIQVKQHYGFVLYRTTLPQDCSNPAPLSSPLNGVHDRAYVAVDGIPQGVLERNNVITLNITGKAGATLDLLVENMGRVNYG
AYINDFKGLVSNLTLSSNILTDWTIFPLDTEDAVCSHLGGWGHRDSGHHDEAWAHNSSNYTLPAFYMGNFSIPSGIPDLPQDTFIQFPGW
TKGQVWINGFNLGRYWPARGPQLTLFVPQHILMTSAPNTITVLELEWAPCSSDDPELCAVTFVDRPVIGSSVTYDHPSKPVEKRLMPPPP

--------------------------------------------------------------
>76372_76372_2_RPL28-GLB1_RPL28_chr19_55899416_ENST00000458349_GLB1_chr3_33114206_ENST00000307363_length(transcript)=2720nt_BP=324nt
ATGTCTGCGCATCTGCAATGGATGGTCGTGCGGAACTGCTCCAGTTTCCTGATCAAGAGGAATAAGCAGACCTACAGCACTGAGCCCAAT
AACTTGAAGGCCCGCAATTCCTTCCGCTACAACGGACTGATTCACCGCAAGACTGTGGGCGTGGAGCCGGCAGCCGACGGCAAAGGTGTC
GTGGTGGTCATTAAGCGGAGATCCGGCCAGCGGAAGCCTGCCACCTCCTATGTGCGGACCACCATCAACAAGAATGCTCGCGCCACGCTC
AGCAGCATCAGACACATGATCCGCAAGAACAAGTACCGCCCCGACCTGCGCATGAATGCCACCCAGAGGATGTTTGAAATTGACTATAGC
CGGGACTCCTTCCTCAAGGATGGCCAGCCATTTCGCTACATCTCAGGAAGCATTCACTACTCCCGTGTGCCCCGCTTCTACTGGAAGGAC
CGGCTGCTGAAGATGAAGATGGCTGGGCTGAACGCCATCCAGACGTATGTGCCCTGGAACTTTCATGAGCCCTGGCCAGGACAGTACCAG
TTTTCTGAGGACCATGATGTGGAATATTTTCTTCGGCTGGCTCATGAGCTGGGACTGCTGGTTATCCTGAGGCCCGGGCCCTACATCTGT
GCAGAGTGGGAAATGGGAGGATTACCTGCTTGGCTGCTAGAGAAAGAGTCTATTCTTCTCCGCTCCTCCGACCCAGATTACCTGGCAGCT
GTGGACAAGTGGTTGGGAGTCCTTCTGCCCAAGATGAAGCCTCTCCTCTATCAGAATGGAGGGCCAGTTATAACAGTGCAGGTTGAAAAT
GAATATGGCAGCTACTTTGCCTGTGATTTTGACTACCTGCGCTTCCTGCAGAAGCGCTTTCGCCACCATCTGGGGGATGATGTGGTTCTG
TTTACCACTGATGGAGCACATAAAACATTCCTGAAATGTGGGGCCCTGCAGGGCCTCTACACCACGGTGGACTTTGGAACAGGCAGCAAC
ATCACAGATGCTTTCCTAAGCCAGAGGAAGTGTGAGCCCAAAGGACCCTTGATCAATTCTGAATTCTATACTGGCTGGCTAGATCACTGG
GGCCAACCTCACTCCACAATCAAGACCGAAGCAGTGGCTTCCTCCCTCTATGATATACTTGCCCGTGGGGCGAGTGTGAACTTGTACATG
TTTATAGGTGGGACCAATTTTGCCTATTGGAATGGGGCCAACTCACCCTATGCAGCACAGCCCACCAGCTACGACTATGATGCCCCACTG
AGTGAGGCTGGGGACCTCACTGAGAAGTATTTTGCTCTGCGAAACATCATCCAGAAGTTTGAAAAAGTACCAGAAGGTCCTATCCCTCCA
TCTACACCAAAGTTTGCATATGGAAAGGTCACTTTGGAAAAGTTAAAGACAGTGGGAGCAGCTCTGGACATTCTGTGTCCCTCTGGGCCC
ATCAAAAGCCTTTATCCCTTGACATTTATCCAGGTGAAACAGCATTATGGGTTTGTGCTGTACCGGACAACACTTCCTCAAGATTGCAGC
AACCCAGCACCTCTCTCTTCACCCCTCAATGGAGTCCACGATCGAGCATATGTTGCTGTGGATGGGATCCCCCAGGGAGTCCTTGAGCGA
AACAATGTGATCACTCTGAACATAACAGGGAAAGCTGGAGCCACTCTGGACCTTCTGGTAGAGAACATGGGACGTGTGAACTATGGTGCA
TATATCAACGATTTTAAGGGTTTGGTTTCTAACCTGACTCTCAGTTCCAATATCCTCACGGACTGGACGATCTTTCCACTGGACACTGAG
GATGCAGTGTGCAGCCACCTGGGGGGCTGGGGACACCGTGACAGTGGCCACCATGATGAAGCCTGGGCCCACAACTCATCCAACTACACG
CTCCCGGCCTTTTATATGGGGAACTTCTCCATTCCCAGTGGGATCCCAGACTTGCCCCAGGACACCTTTATCCAGTTTCCTGGATGGACC
AAGGGCCAGGTCTGGATTAATGGCTTTAACCTTGGCCGCTATTGGCCAGCCCGGGGCCCTCAGTTGACCTTGTTTGTGCCCCAGCACATC
CTGATGACCTCGGCCCCAAACACCATCACCGTGCTGGAACTGGAGTGGGCACCCTGCAGCAGTGATGATCCAGAACTATGTGCTGTGACG
TTCGTGGACAGGCCAGTTATTGGCTCATCTGTGACCTACGATCATCCCTCCAAACCTGTTGAAAAAAGACTCATGCCCCCACCCCCGCAA
AAAAACAAAGATTCATGGCTGGACCATGTATGATGATGAAAGCCTGTGTCTTTGAGGGATTCTACCCTGAACATACCTCACAGATCCTCC
CTGTCATGCCACATTTCACTGATTGGAATGTGGAAATGGAAAAGGAATTTAGGATGTGCATTTTCACCTGAGGTTTCCCTGCATCCCTGC
AGTGCCAAAGCCCCACCTTCAGGGACCACCTGGAATGTGTGAGGGGCTGACAGCACAGTAACGTGCATACATATCTGCAGGGCTGGAATG
GAAGCTTTAAAGGTGGTAGTGATTTTTATTTTGGAAGAATCATGTTACCTTTTTGTTAAATAAAATTTGTACTCAAATGATGATGTCACT
GTTTTTAATGTGCAGGTATTGAATTATATGGTCTGACTTAAATCATAACTAGACTTGAGTGGGCTGAATAAACCACTTCACTAACTTGAA

>76372_76372_2_RPL28-GLB1_RPL28_chr19_55899416_ENST00000458349_GLB1_chr3_33114206_ENST00000307363_length(amino acids)=760AA_BP=108
MSAHLQWMVVRNCSSFLIKRNKQTYSTEPNNLKARNSFRYNGLIHRKTVGVEPAADGKGVVVVIKRRSGQRKPATSYVRTTINKNARATL
SSIRHMIRKNKYRPDLRMNATQRMFEIDYSRDSFLKDGQPFRYISGSIHYSRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPWPGQYQ
FSEDHDVEYFLRLAHELGLLVILRPGPYICAEWEMGGLPAWLLEKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPVITVQVEN
EYGSYFACDFDYLRFLQKRFRHHLGDDVVLFTTDGAHKTFLKCGALQGLYTTVDFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDHW
GQPHSTIKTEAVASSLYDILARGASVNLYMFIGGTNFAYWNGANSPYAAQPTSYDYDAPLSEAGDLTEKYFALRNIIQKFEKVPEGPIPP
STPKFAYGKVTLEKLKTVGAALDILCPSGPIKSLYPLTFIQVKQHYGFVLYRTTLPQDCSNPAPLSSPLNGVHDRAYVAVDGIPQGVLER
NNVITLNITGKAGATLDLLVENMGRVNYGAYINDFKGLVSNLTLSSNILTDWTIFPLDTEDAVCSHLGGWGHRDSGHHDEAWAHNSSNYT
LPAFYMGNFSIPSGIPDLPQDTFIQFPGWTKGQVWINGFNLGRYWPARGPQLTLFVPQHILMTSAPNTITVLELEWAPCSSDDPELCAVT

--------------------------------------------------------------
>76372_76372_3_RPL28-GLB1_RPL28_chr19_55899416_ENST00000558815_GLB1_chr3_33114206_ENST00000307363_length(transcript)=2762nt_BP=366nt
CTCTTTCCGTCTCAGGTCGCCGCTGCGAAGGGAGCCGCCGCCATGTCTGCGCATCTGCAATGGATGGTCGTGCGGAACTGCTCCAGTTTC
CTGATCAAGAGGAATAAGCAGACCTACAGCACTGAGCCCAATAACTTGAAGGCCCGCAATTCCTTCCGCTACAACGGACTGATTCACCGC
AAGACTGTGGGCGTGGAGCCGGCAGCCGACGGCAAAGGTGTCGTGGTGGTCATTAAGCGGAGATCCGGCCAGCGGAAGCCTGCCACCTCC
TATGTGCGGACCACCATCAACAAGAATGCTCGCGCCACGCTCAGCAGCATCAGACACATGATCCGCAAGAACAAGTACCGCCCCGACCTG
CGCATGAATGCCACCCAGAGGATGTTTGAAATTGACTATAGCCGGGACTCCTTCCTCAAGGATGGCCAGCCATTTCGCTACATCTCAGGA
AGCATTCACTACTCCCGTGTGCCCCGCTTCTACTGGAAGGACCGGCTGCTGAAGATGAAGATGGCTGGGCTGAACGCCATCCAGACGTAT
GTGCCCTGGAACTTTCATGAGCCCTGGCCAGGACAGTACCAGTTTTCTGAGGACCATGATGTGGAATATTTTCTTCGGCTGGCTCATGAG
CTGGGACTGCTGGTTATCCTGAGGCCCGGGCCCTACATCTGTGCAGAGTGGGAAATGGGAGGATTACCTGCTTGGCTGCTAGAGAAAGAG
TCTATTCTTCTCCGCTCCTCCGACCCAGATTACCTGGCAGCTGTGGACAAGTGGTTGGGAGTCCTTCTGCCCAAGATGAAGCCTCTCCTC
TATCAGAATGGAGGGCCAGTTATAACAGTGCAGGTTGAAAATGAATATGGCAGCTACTTTGCCTGTGATTTTGACTACCTGCGCTTCCTG
CAGAAGCGCTTTCGCCACCATCTGGGGGATGATGTGGTTCTGTTTACCACTGATGGAGCACATAAAACATTCCTGAAATGTGGGGCCCTG
CAGGGCCTCTACACCACGGTGGACTTTGGAACAGGCAGCAACATCACAGATGCTTTCCTAAGCCAGAGGAAGTGTGAGCCCAAAGGACCC
TTGATCAATTCTGAATTCTATACTGGCTGGCTAGATCACTGGGGCCAACCTCACTCCACAATCAAGACCGAAGCAGTGGCTTCCTCCCTC
TATGATATACTTGCCCGTGGGGCGAGTGTGAACTTGTACATGTTTATAGGTGGGACCAATTTTGCCTATTGGAATGGGGCCAACTCACCC
TATGCAGCACAGCCCACCAGCTACGACTATGATGCCCCACTGAGTGAGGCTGGGGACCTCACTGAGAAGTATTTTGCTCTGCGAAACATC
ATCCAGAAGTTTGAAAAAGTACCAGAAGGTCCTATCCCTCCATCTACACCAAAGTTTGCATATGGAAAGGTCACTTTGGAAAAGTTAAAG
ACAGTGGGAGCAGCTCTGGACATTCTGTGTCCCTCTGGGCCCATCAAAAGCCTTTATCCCTTGACATTTATCCAGGTGAAACAGCATTAT
GGGTTTGTGCTGTACCGGACAACACTTCCTCAAGATTGCAGCAACCCAGCACCTCTCTCTTCACCCCTCAATGGAGTCCACGATCGAGCA
TATGTTGCTGTGGATGGGATCCCCCAGGGAGTCCTTGAGCGAAACAATGTGATCACTCTGAACATAACAGGGAAAGCTGGAGCCACTCTG
GACCTTCTGGTAGAGAACATGGGACGTGTGAACTATGGTGCATATATCAACGATTTTAAGGGTTTGGTTTCTAACCTGACTCTCAGTTCC
AATATCCTCACGGACTGGACGATCTTTCCACTGGACACTGAGGATGCAGTGTGCAGCCACCTGGGGGGCTGGGGACACCGTGACAGTGGC
CACCATGATGAAGCCTGGGCCCACAACTCATCCAACTACACGCTCCCGGCCTTTTATATGGGGAACTTCTCCATTCCCAGTGGGATCCCA
GACTTGCCCCAGGACACCTTTATCCAGTTTCCTGGATGGACCAAGGGCCAGGTCTGGATTAATGGCTTTAACCTTGGCCGCTATTGGCCA
GCCCGGGGCCCTCAGTTGACCTTGTTTGTGCCCCAGCACATCCTGATGACCTCGGCCCCAAACACCATCACCGTGCTGGAACTGGAGTGG
GCACCCTGCAGCAGTGATGATCCAGAACTATGTGCTGTGACGTTCGTGGACAGGCCAGTTATTGGCTCATCTGTGACCTACGATCATCCC
TCCAAACCTGTTGAAAAAAGACTCATGCCCCCACCCCCGCAAAAAAACAAAGATTCATGGCTGGACCATGTATGATGATGAAAGCCTGTG
TCTTTGAGGGATTCTACCCTGAACATACCTCACAGATCCTCCCTGTCATGCCACATTTCACTGATTGGAATGTGGAAATGGAAAAGGAAT
TTAGGATGTGCATTTTCACCTGAGGTTTCCCTGCATCCCTGCAGTGCCAAAGCCCCACCTTCAGGGACCACCTGGAATGTGTGAGGGGCT
GACAGCACAGTAACGTGCATACATATCTGCAGGGCTGGAATGGAAGCTTTAAAGGTGGTAGTGATTTTTATTTTGGAAGAATCATGTTAC
CTTTTTGTTAAATAAAATTTGTACTCAAATGATGATGTCACTGTTTTTAATGTGCAGGTATTGAATTATATGGTCTGACTTAAATCATAA

>76372_76372_3_RPL28-GLB1_RPL28_chr19_55899416_ENST00000558815_GLB1_chr3_33114206_ENST00000307363_length(amino acids)=760AA_BP=108
MSAHLQWMVVRNCSSFLIKRNKQTYSTEPNNLKARNSFRYNGLIHRKTVGVEPAADGKGVVVVIKRRSGQRKPATSYVRTTINKNARATL
SSIRHMIRKNKYRPDLRMNATQRMFEIDYSRDSFLKDGQPFRYISGSIHYSRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPWPGQYQ
FSEDHDVEYFLRLAHELGLLVILRPGPYICAEWEMGGLPAWLLEKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPVITVQVEN
EYGSYFACDFDYLRFLQKRFRHHLGDDVVLFTTDGAHKTFLKCGALQGLYTTVDFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDHW
GQPHSTIKTEAVASSLYDILARGASVNLYMFIGGTNFAYWNGANSPYAAQPTSYDYDAPLSEAGDLTEKYFALRNIIQKFEKVPEGPIPP
STPKFAYGKVTLEKLKTVGAALDILCPSGPIKSLYPLTFIQVKQHYGFVLYRTTLPQDCSNPAPLSSPLNGVHDRAYVAVDGIPQGVLER
NNVITLNITGKAGATLDLLVENMGRVNYGAYINDFKGLVSNLTLSSNILTDWTIFPLDTEDAVCSHLGGWGHRDSGHHDEAWAHNSSNYT
LPAFYMGNFSIPSGIPDLPQDTFIQFPGWTKGQVWINGFNLGRYWPARGPQLTLFVPQHILMTSAPNTITVLELEWAPCSSDDPELCAVT

--------------------------------------------------------------
>76372_76372_4_RPL28-GLB1_RPL28_chr19_55899416_ENST00000559463_GLB1_chr3_33114206_ENST00000307363_length(transcript)=3117nt_BP=721nt
GGGAGGTGAGCGTTCGTCTTCCTCGCGTGGTCGCCATCTCCGGCCCGCCGCGCACTCCCTCTCAGTCCTCTGCCTGCCTTCTCCCCTTGC
GCCTCAAGGGTCATTGGCGGACCCCAACCCCTCCCCGTGAAGTCGTTGTGAATTTTCAAGTTATTTTCCCCTCACTCTCATTCGCCGCAG
CTAGTCTCGGCTGCCTGAATTCGGTCCCGCCGCCTTAGGTCACTCAGTCCCGCCTGACAAGAGTTCTAGGTCGCTGTCTGCCCTCAGGGG
TCTCCCATTCACCCAAGTTCCCAGTCGCTCTCTTCCTCTGCTGTCCGAGCGTGGCCCGTGGCCTAACGCTGCTTTAGTTCTCTGTGTCTG
ACGCTTTCCCTGTGCCCGTTTCCCCGCAGCCGCCGCCATGTCTGCGCATCTGCAATGGATGGTCGTGCGGAACTGCTCCAGTTTCCTGAT
CAAGAGGAATAAGCAGACCTACAGCACTGAGCCCAATAACTTGAAGGCCCGCAATTCCTTCCGCTACAACGGACTGATTCACCGCAAGAC
TGTGGGCGTGGAGCCGGCAGCCGACGGCAAAGGTGTCGTGGTGGTCATTAAGCGGAGATCCGGCCAGCGGAAGCCTGCCACCTCCTATGT
GCGGACCACCATCAACAAGAATGCTCGCGCCACGCTCAGCAGCATCAGACACATGATCCGCAAGAACAAGTACCGCCCCGACCTGCGCAT
GAATGCCACCCAGAGGATGTTTGAAATTGACTATAGCCGGGACTCCTTCCTCAAGGATGGCCAGCCATTTCGCTACATCTCAGGAAGCAT
TCACTACTCCCGTGTGCCCCGCTTCTACTGGAAGGACCGGCTGCTGAAGATGAAGATGGCTGGGCTGAACGCCATCCAGACGTATGTGCC
CTGGAACTTTCATGAGCCCTGGCCAGGACAGTACCAGTTTTCTGAGGACCATGATGTGGAATATTTTCTTCGGCTGGCTCATGAGCTGGG
ACTGCTGGTTATCCTGAGGCCCGGGCCCTACATCTGTGCAGAGTGGGAAATGGGAGGATTACCTGCTTGGCTGCTAGAGAAAGAGTCTAT
TCTTCTCCGCTCCTCCGACCCAGATTACCTGGCAGCTGTGGACAAGTGGTTGGGAGTCCTTCTGCCCAAGATGAAGCCTCTCCTCTATCA
GAATGGAGGGCCAGTTATAACAGTGCAGGTTGAAAATGAATATGGCAGCTACTTTGCCTGTGATTTTGACTACCTGCGCTTCCTGCAGAA
GCGCTTTCGCCACCATCTGGGGGATGATGTGGTTCTGTTTACCACTGATGGAGCACATAAAACATTCCTGAAATGTGGGGCCCTGCAGGG
CCTCTACACCACGGTGGACTTTGGAACAGGCAGCAACATCACAGATGCTTTCCTAAGCCAGAGGAAGTGTGAGCCCAAAGGACCCTTGAT
CAATTCTGAATTCTATACTGGCTGGCTAGATCACTGGGGCCAACCTCACTCCACAATCAAGACCGAAGCAGTGGCTTCCTCCCTCTATGA
TATACTTGCCCGTGGGGCGAGTGTGAACTTGTACATGTTTATAGGTGGGACCAATTTTGCCTATTGGAATGGGGCCAACTCACCCTATGC
AGCACAGCCCACCAGCTACGACTATGATGCCCCACTGAGTGAGGCTGGGGACCTCACTGAGAAGTATTTTGCTCTGCGAAACATCATCCA
GAAGTTTGAAAAAGTACCAGAAGGTCCTATCCCTCCATCTACACCAAAGTTTGCATATGGAAAGGTCACTTTGGAAAAGTTAAAGACAGT
GGGAGCAGCTCTGGACATTCTGTGTCCCTCTGGGCCCATCAAAAGCCTTTATCCCTTGACATTTATCCAGGTGAAACAGCATTATGGGTT
TGTGCTGTACCGGACAACACTTCCTCAAGATTGCAGCAACCCAGCACCTCTCTCTTCACCCCTCAATGGAGTCCACGATCGAGCATATGT
TGCTGTGGATGGGATCCCCCAGGGAGTCCTTGAGCGAAACAATGTGATCACTCTGAACATAACAGGGAAAGCTGGAGCCACTCTGGACCT
TCTGGTAGAGAACATGGGACGTGTGAACTATGGTGCATATATCAACGATTTTAAGGGTTTGGTTTCTAACCTGACTCTCAGTTCCAATAT
CCTCACGGACTGGACGATCTTTCCACTGGACACTGAGGATGCAGTGTGCAGCCACCTGGGGGGCTGGGGACACCGTGACAGTGGCCACCA
TGATGAAGCCTGGGCCCACAACTCATCCAACTACACGCTCCCGGCCTTTTATATGGGGAACTTCTCCATTCCCAGTGGGATCCCAGACTT
GCCCCAGGACACCTTTATCCAGTTTCCTGGATGGACCAAGGGCCAGGTCTGGATTAATGGCTTTAACCTTGGCCGCTATTGGCCAGCCCG
GGGCCCTCAGTTGACCTTGTTTGTGCCCCAGCACATCCTGATGACCTCGGCCCCAAACACCATCACCGTGCTGGAACTGGAGTGGGCACC
CTGCAGCAGTGATGATCCAGAACTATGTGCTGTGACGTTCGTGGACAGGCCAGTTATTGGCTCATCTGTGACCTACGATCATCCCTCCAA
ACCTGTTGAAAAAAGACTCATGCCCCCACCCCCGCAAAAAAACAAAGATTCATGGCTGGACCATGTATGATGATGAAAGCCTGTGTCTTT
GAGGGATTCTACCCTGAACATACCTCACAGATCCTCCCTGTCATGCCACATTTCACTGATTGGAATGTGGAAATGGAAAAGGAATTTAGG
ATGTGCATTTTCACCTGAGGTTTCCCTGCATCCCTGCAGTGCCAAAGCCCCACCTTCAGGGACCACCTGGAATGTGTGAGGGGCTGACAG
CACAGTAACGTGCATACATATCTGCAGGGCTGGAATGGAAGCTTTAAAGGTGGTAGTGATTTTTATTTTGGAAGAATCATGTTACCTTTT
TGTTAAATAAAATTTGTACTCAAATGATGATGTCACTGTTTTTAATGTGCAGGTATTGAATTATATGGTCTGACTTAAATCATAACTAGA

>76372_76372_4_RPL28-GLB1_RPL28_chr19_55899416_ENST00000559463_GLB1_chr3_33114206_ENST00000307363_length(amino acids)=760AA_BP=108
MSAHLQWMVVRNCSSFLIKRNKQTYSTEPNNLKARNSFRYNGLIHRKTVGVEPAADGKGVVVVIKRRSGQRKPATSYVRTTINKNARATL
SSIRHMIRKNKYRPDLRMNATQRMFEIDYSRDSFLKDGQPFRYISGSIHYSRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPWPGQYQ
FSEDHDVEYFLRLAHELGLLVILRPGPYICAEWEMGGLPAWLLEKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPVITVQVEN
EYGSYFACDFDYLRFLQKRFRHHLGDDVVLFTTDGAHKTFLKCGALQGLYTTVDFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDHW
GQPHSTIKTEAVASSLYDILARGASVNLYMFIGGTNFAYWNGANSPYAAQPTSYDYDAPLSEAGDLTEKYFALRNIIQKFEKVPEGPIPP
STPKFAYGKVTLEKLKTVGAALDILCPSGPIKSLYPLTFIQVKQHYGFVLYRTTLPQDCSNPAPLSSPLNGVHDRAYVAVDGIPQGVLER
NNVITLNITGKAGATLDLLVENMGRVNYGAYINDFKGLVSNLTLSSNILTDWTIFPLDTEDAVCSHLGGWGHRDSGHHDEAWAHNSSNYT
LPAFYMGNFSIPSGIPDLPQDTFIQFPGWTKGQVWINGFNLGRYWPARGPQLTLFVPQHILMTSAPNTITVLELEWAPCSSDDPELCAVT

--------------------------------------------------------------
>76372_76372_5_RPL28-GLB1_RPL28_chr19_55899416_ENST00000560055_GLB1_chr3_33114206_ENST00000307363_length(transcript)=2758nt_BP=362nt
TTCCGTCTCAGGTCGCCGCTGCGAAGGGAGCCGCCGCCATGTCTGCGCATCTGCAATGGATGGTCGTGCGGAACTGCTCCAGTTTCCTGA
TCAAGAGGAATAAGCAGACCTACAGCACTGAGCCCAATAACTTGAAGGCCCGCAATTCCTTCCGCTACAACGGACTGATTCACCGCAAGA
CTGTGGGCGTGGAGCCGGCAGCCGACGGCAAAGGTGTCGTGGTGGTCATTAAGCGGAGATCCGGCCAGCGGAAGCCTGCCACCTCCTATG
TGCGGACCACCATCAACAAGAATGCTCGCGCCACGCTCAGCAGCATCAGACACATGATCCGCAAGAACAAGTACCGCCCCGACCTGCGCA
TGAATGCCACCCAGAGGATGTTTGAAATTGACTATAGCCGGGACTCCTTCCTCAAGGATGGCCAGCCATTTCGCTACATCTCAGGAAGCA
TTCACTACTCCCGTGTGCCCCGCTTCTACTGGAAGGACCGGCTGCTGAAGATGAAGATGGCTGGGCTGAACGCCATCCAGACGTATGTGC
CCTGGAACTTTCATGAGCCCTGGCCAGGACAGTACCAGTTTTCTGAGGACCATGATGTGGAATATTTTCTTCGGCTGGCTCATGAGCTGG
GACTGCTGGTTATCCTGAGGCCCGGGCCCTACATCTGTGCAGAGTGGGAAATGGGAGGATTACCTGCTTGGCTGCTAGAGAAAGAGTCTA
TTCTTCTCCGCTCCTCCGACCCAGATTACCTGGCAGCTGTGGACAAGTGGTTGGGAGTCCTTCTGCCCAAGATGAAGCCTCTCCTCTATC
AGAATGGAGGGCCAGTTATAACAGTGCAGGTTGAAAATGAATATGGCAGCTACTTTGCCTGTGATTTTGACTACCTGCGCTTCCTGCAGA
AGCGCTTTCGCCACCATCTGGGGGATGATGTGGTTCTGTTTACCACTGATGGAGCACATAAAACATTCCTGAAATGTGGGGCCCTGCAGG
GCCTCTACACCACGGTGGACTTTGGAACAGGCAGCAACATCACAGATGCTTTCCTAAGCCAGAGGAAGTGTGAGCCCAAAGGACCCTTGA
TCAATTCTGAATTCTATACTGGCTGGCTAGATCACTGGGGCCAACCTCACTCCACAATCAAGACCGAAGCAGTGGCTTCCTCCCTCTATG
ATATACTTGCCCGTGGGGCGAGTGTGAACTTGTACATGTTTATAGGTGGGACCAATTTTGCCTATTGGAATGGGGCCAACTCACCCTATG
CAGCACAGCCCACCAGCTACGACTATGATGCCCCACTGAGTGAGGCTGGGGACCTCACTGAGAAGTATTTTGCTCTGCGAAACATCATCC
AGAAGTTTGAAAAAGTACCAGAAGGTCCTATCCCTCCATCTACACCAAAGTTTGCATATGGAAAGGTCACTTTGGAAAAGTTAAAGACAG
TGGGAGCAGCTCTGGACATTCTGTGTCCCTCTGGGCCCATCAAAAGCCTTTATCCCTTGACATTTATCCAGGTGAAACAGCATTATGGGT
TTGTGCTGTACCGGACAACACTTCCTCAAGATTGCAGCAACCCAGCACCTCTCTCTTCACCCCTCAATGGAGTCCACGATCGAGCATATG
TTGCTGTGGATGGGATCCCCCAGGGAGTCCTTGAGCGAAACAATGTGATCACTCTGAACATAACAGGGAAAGCTGGAGCCACTCTGGACC
TTCTGGTAGAGAACATGGGACGTGTGAACTATGGTGCATATATCAACGATTTTAAGGGTTTGGTTTCTAACCTGACTCTCAGTTCCAATA
TCCTCACGGACTGGACGATCTTTCCACTGGACACTGAGGATGCAGTGTGCAGCCACCTGGGGGGCTGGGGACACCGTGACAGTGGCCACC
ATGATGAAGCCTGGGCCCACAACTCATCCAACTACACGCTCCCGGCCTTTTATATGGGGAACTTCTCCATTCCCAGTGGGATCCCAGACT
TGCCCCAGGACACCTTTATCCAGTTTCCTGGATGGACCAAGGGCCAGGTCTGGATTAATGGCTTTAACCTTGGCCGCTATTGGCCAGCCC
GGGGCCCTCAGTTGACCTTGTTTGTGCCCCAGCACATCCTGATGACCTCGGCCCCAAACACCATCACCGTGCTGGAACTGGAGTGGGCAC
CCTGCAGCAGTGATGATCCAGAACTATGTGCTGTGACGTTCGTGGACAGGCCAGTTATTGGCTCATCTGTGACCTACGATCATCCCTCCA
AACCTGTTGAAAAAAGACTCATGCCCCCACCCCCGCAAAAAAACAAAGATTCATGGCTGGACCATGTATGATGATGAAAGCCTGTGTCTT
TGAGGGATTCTACCCTGAACATACCTCACAGATCCTCCCTGTCATGCCACATTTCACTGATTGGAATGTGGAAATGGAAAAGGAATTTAG
GATGTGCATTTTCACCTGAGGTTTCCCTGCATCCCTGCAGTGCCAAAGCCCCACCTTCAGGGACCACCTGGAATGTGTGAGGGGCTGACA
GCACAGTAACGTGCATACATATCTGCAGGGCTGGAATGGAAGCTTTAAAGGTGGTAGTGATTTTTATTTTGGAAGAATCATGTTACCTTT
TTGTTAAATAAAATTTGTACTCAAATGATGATGTCACTGTTTTTAATGTGCAGGTATTGAATTATATGGTCTGACTTAAATCATAACTAG

>76372_76372_5_RPL28-GLB1_RPL28_chr19_55899416_ENST00000560055_GLB1_chr3_33114206_ENST00000307363_length(amino acids)=760AA_BP=108
MSAHLQWMVVRNCSSFLIKRNKQTYSTEPNNLKARNSFRYNGLIHRKTVGVEPAADGKGVVVVIKRRSGQRKPATSYVRTTINKNARATL
SSIRHMIRKNKYRPDLRMNATQRMFEIDYSRDSFLKDGQPFRYISGSIHYSRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPWPGQYQ
FSEDHDVEYFLRLAHELGLLVILRPGPYICAEWEMGGLPAWLLEKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPVITVQVEN
EYGSYFACDFDYLRFLQKRFRHHLGDDVVLFTTDGAHKTFLKCGALQGLYTTVDFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDHW
GQPHSTIKTEAVASSLYDILARGASVNLYMFIGGTNFAYWNGANSPYAAQPTSYDYDAPLSEAGDLTEKYFALRNIIQKFEKVPEGPIPP
STPKFAYGKVTLEKLKTVGAALDILCPSGPIKSLYPLTFIQVKQHYGFVLYRTTLPQDCSNPAPLSSPLNGVHDRAYVAVDGIPQGVLER
NNVITLNITGKAGATLDLLVENMGRVNYGAYINDFKGLVSNLTLSSNILTDWTIFPLDTEDAVCSHLGGWGHRDSGHHDEAWAHNSSNYT
LPAFYMGNFSIPSGIPDLPQDTFIQFPGWTKGQVWINGFNLGRYWPARGPQLTLFVPQHILMTSAPNTITVLELEWAPCSSDDPELCAVT

--------------------------------------------------------------
>76372_76372_6_RPL28-GLB1_RPL28_chr19_55899416_ENST00000560583_GLB1_chr3_33114206_ENST00000307363_length(transcript)=3481nt_BP=1085nt
CTTTCCGTCTCAGGTCGCCGCTGCGAAGGGAGCCGCCGCCATGTCTGCGCATCTGCAATGGATGGTCGTGCGGAACTGCTCCAGTTTCCT
GATCAAGAGGAATAAGCAGACCTACAGCACTGAGCCCAATAACTTGAAGGCCCGCAATTCCTTCCGCTACAACGGACTGATTCACCGCAA
GACTGTGGGCGTGGAGCCGGCAGCCGACGGCAAAGGTGTCGTGGTGGTCATTAAGCGGAGATCCGGTGAGCTGGGGTTTGGGGATCAGGC
TTGGGGAGACTGGCCAGTGCTGTGGGGAAGGGCCTCCCACTACTGGTTGCAATATGGGCTGGAGAGGGATGGATTCTTGCTTTCAGCCTA
CTCCCCACACCCAGCATTGGCCTAGGGGGCGGCTTGTGGAGTGTATGGGCTGAGCCTTGCTCTGCTCCCCCGCCCCCAGGCAGCCATCCG
CAGGGCCAGCGCCATCCTGCGCAGCCAGAAGCCTGTGATGGTGAAGAGGAAGCGGACCCGCCCCACCAAGAGCTCCTGAGCCCCCTGCCC
CCAGAGCAATAAAGTCAGCTGGCTTTCTCACCTGCCTCGACTGGGCCTCCCTTTTTGAAACGCTCTGGGGAGCTCTGGCCCTGTGTGTTG
TCATTCAGGCCATGTCATCAAAACTCTGCATGTCACCTTGTCCATCTGGAGGTGATGTCAATGGCTGGCCATGCAGGAGGGGTGGGGTAG
CTGCCTTGTCCCTGGTGAGGGCAAGGGTCACTGTCTTCACAGAAAAAGTTTGCTGACTTGTGATTGAGACCTACTGTCCCATTGTGAGGT
GGCCTGAAGAATCCCAGCTGGGGCAGTGGCTTCCATTCAGAAGAAGAAAGGCCTTTTCTAGCCCAGAAGGGTGCAGGCTGAGGGCTGGGC
CCTGGGCCCTGGTGCTGTAGCACGGTTTGGGGACTTGGGGTGTTCCCAAGACCTGGGGGACGACAGACATCACGGGAGGAAGATGAGATG
ACTTTTGCATCCAGGGAGTGGGTGCAGCCACATTTGGAGGGGATGGGCTTTACTTGATGCAACCTCATCTCTGAGATGGGCAACTTGGTG
GGTGGAATGCCACCCAGAGGATGTTTGAAATTGACTATAGCCGGGACTCCTTCCTCAAGGATGGCCAGCCATTTCGCTACATCTCAGGAA
GCATTCACTACTCCCGTGTGCCCCGCTTCTACTGGAAGGACCGGCTGCTGAAGATGAAGATGGCTGGGCTGAACGCCATCCAGACGTATG
TGCCCTGGAACTTTCATGAGCCCTGGCCAGGACAGTACCAGTTTTCTGAGGACCATGATGTGGAATATTTTCTTCGGCTGGCTCATGAGC
TGGGACTGCTGGTTATCCTGAGGCCCGGGCCCTACATCTGTGCAGAGTGGGAAATGGGAGGATTACCTGCTTGGCTGCTAGAGAAAGAGT
CTATTCTTCTCCGCTCCTCCGACCCAGATTACCTGGCAGCTGTGGACAAGTGGTTGGGAGTCCTTCTGCCCAAGATGAAGCCTCTCCTCT
ATCAGAATGGAGGGCCAGTTATAACAGTGCAGGTTGAAAATGAATATGGCAGCTACTTTGCCTGTGATTTTGACTACCTGCGCTTCCTGC
AGAAGCGCTTTCGCCACCATCTGGGGGATGATGTGGTTCTGTTTACCACTGATGGAGCACATAAAACATTCCTGAAATGTGGGGCCCTGC
AGGGCCTCTACACCACGGTGGACTTTGGAACAGGCAGCAACATCACAGATGCTTTCCTAAGCCAGAGGAAGTGTGAGCCCAAAGGACCCT
TGATCAATTCTGAATTCTATACTGGCTGGCTAGATCACTGGGGCCAACCTCACTCCACAATCAAGACCGAAGCAGTGGCTTCCTCCCTCT
ATGATATACTTGCCCGTGGGGCGAGTGTGAACTTGTACATGTTTATAGGTGGGACCAATTTTGCCTATTGGAATGGGGCCAACTCACCCT
ATGCAGCACAGCCCACCAGCTACGACTATGATGCCCCACTGAGTGAGGCTGGGGACCTCACTGAGAAGTATTTTGCTCTGCGAAACATCA
TCCAGAAGTTTGAAAAAGTACCAGAAGGTCCTATCCCTCCATCTACACCAAAGTTTGCATATGGAAAGGTCACTTTGGAAAAGTTAAAGA
CAGTGGGAGCAGCTCTGGACATTCTGTGTCCCTCTGGGCCCATCAAAAGCCTTTATCCCTTGACATTTATCCAGGTGAAACAGCATTATG
GGTTTGTGCTGTACCGGACAACACTTCCTCAAGATTGCAGCAACCCAGCACCTCTCTCTTCACCCCTCAATGGAGTCCACGATCGAGCAT
ATGTTGCTGTGGATGGGATCCCCCAGGGAGTCCTTGAGCGAAACAATGTGATCACTCTGAACATAACAGGGAAAGCTGGAGCCACTCTGG
ACCTTCTGGTAGAGAACATGGGACGTGTGAACTATGGTGCATATATCAACGATTTTAAGGGTTTGGTTTCTAACCTGACTCTCAGTTCCA
ATATCCTCACGGACTGGACGATCTTTCCACTGGACACTGAGGATGCAGTGTGCAGCCACCTGGGGGGCTGGGGACACCGTGACAGTGGCC
ACCATGATGAAGCCTGGGCCCACAACTCATCCAACTACACGCTCCCGGCCTTTTATATGGGGAACTTCTCCATTCCCAGTGGGATCCCAG
ACTTGCCCCAGGACACCTTTATCCAGTTTCCTGGATGGACCAAGGGCCAGGTCTGGATTAATGGCTTTAACCTTGGCCGCTATTGGCCAG
CCCGGGGCCCTCAGTTGACCTTGTTTGTGCCCCAGCACATCCTGATGACCTCGGCCCCAAACACCATCACCGTGCTGGAACTGGAGTGGG
CACCCTGCAGCAGTGATGATCCAGAACTATGTGCTGTGACGTTCGTGGACAGGCCAGTTATTGGCTCATCTGTGACCTACGATCATCCCT
CCAAACCTGTTGAAAAAAGACTCATGCCCCCACCCCCGCAAAAAAACAAAGATTCATGGCTGGACCATGTATGATGATGAAAGCCTGTGT
CTTTGAGGGATTCTACCCTGAACATACCTCACAGATCCTCCCTGTCATGCCACATTTCACTGATTGGAATGTGGAAATGGAAAAGGAATT
TAGGATGTGCATTTTCACCTGAGGTTTCCCTGCATCCCTGCAGTGCCAAAGCCCCACCTTCAGGGACCACCTGGAATGTGTGAGGGGCTG
ACAGCACAGTAACGTGCATACATATCTGCAGGGCTGGAATGGAAGCTTTAAAGGTGGTAGTGATTTTTATTTTGGAAGAATCATGTTACC
TTTTTGTTAAATAAAATTTGTACTCAAATGATGATGTCACTGTTTTTAATGTGCAGGTATTGAATTATATGGTCTGACTTAAATCATAAC

>76372_76372_6_RPL28-GLB1_RPL28_chr19_55899416_ENST00000560583_GLB1_chr3_33114206_ENST00000307363_length(amino acids)=647AA_BP=
MFEIDYSRDSFLKDGQPFRYISGSIHYSRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPWPGQYQFSEDHDVEYFLRLAHELGLLVIL
RPGPYICAEWEMGGLPAWLLEKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPVITVQVENEYGSYFACDFDYLRFLQKRFRHH
LGDDVVLFTTDGAHKTFLKCGALQGLYTTVDFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDHWGQPHSTIKTEAVASSLYDILARG
ASVNLYMFIGGTNFAYWNGANSPYAAQPTSYDYDAPLSEAGDLTEKYFALRNIIQKFEKVPEGPIPPSTPKFAYGKVTLEKLKTVGAALD
ILCPSGPIKSLYPLTFIQVKQHYGFVLYRTTLPQDCSNPAPLSSPLNGVHDRAYVAVDGIPQGVLERNNVITLNITGKAGATLDLLVENM
GRVNYGAYINDFKGLVSNLTLSSNILTDWTIFPLDTEDAVCSHLGGWGHRDSGHHDEAWAHNSSNYTLPAFYMGNFSIPSGIPDLPQDTF
IQFPGWTKGQVWINGFNLGRYWPARGPQLTLFVPQHILMTSAPNTITVLELEWAPCSSDDPELCAVTFVDRPVIGSSVTYDHPSKPVEKR

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Fusion Gene PPI Analysis for RPL28-GLB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RPL28-GLB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RPL28-GLB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource