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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RPL30-GUK1 (FusionGDB2 ID:76415)

Fusion Gene Summary for RPL30-GUK1

check button Fusion gene summary
Fusion gene informationFusion gene name: RPL30-GUK1
Fusion gene ID: 76415
HgeneTgene
Gene symbol

RPL30

GUK1

Gene ID

6156

2987

Gene nameribosomal protein L30guanylate kinase 1
SynonymsL30GMK
Cytomap

8q22.2

1q42.13

Type of geneprotein-codingprotein-coding
Description60S ribosomal protein L30large ribosomal subunit protein eL30guanylate kinaseATP:GMP phosphotransferaseGMP kinase
Modification date2020031320200320
UniProtAcc.

Q16774

Ensembl transtripts involved in fusion geneENST00000287038, ENST00000396070, 
ENST00000521291, ENST00000518164, 
ENST00000523172, 		ENST00000366716, 
ENST00000366718, ENST00000366721, 
ENST00000366722, ENST00000366723, 
ENST00000470040, ENST00000312726, 
ENST00000366726, ENST00000366728, 
ENST00000366730, ENST00000391865, 
Fusion gene scores* DoF score15 X 11 X 4=6609 X 8 X 3=216
# samples 1510
** MAII scorelog2(15/660*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/216*10)=-1.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPL30 [Title/Abstract] AND GUK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRPL30(99057170)-GUK1(228336365), # samples:1
Anticipated loss of major functional domain due to fusion event.RPL30-GUK1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
RPL30-GUK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
RPL30-GUK1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
RPL30-GUK1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPL30

GO:0002181

cytoplasmic translation

25957688

HgeneRPL30

GO:0031640

killing of cells of other organism

15019208

HgeneRPL30

GO:0050829

defense response to Gram-negative bacterium

15019208

HgeneRPL30

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

15019208

TgeneGUK1

GO:0006163

purine nucleotide metabolic process

8663313

TgeneGUK1

GO:0006805

xenobiotic metabolic process

6306664


check buttonFusion gene breakpoints across RPL30 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GUK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1471RPL30chr8

99057170

-GUK1chr1

228336365

+


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Fusion Gene ORF analysis for RPL30-GUK1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000287038ENST00000366716RPL30chr8

99057170

-GUK1chr1

228336365

+
5CDS-3UTRENST00000287038ENST00000366718RPL30chr8

99057170

-GUK1chr1

228336365

+
5CDS-3UTRENST00000287038ENST00000366721RPL30chr8

99057170

-GUK1chr1

228336365

+
5CDS-3UTRENST00000287038ENST00000366722RPL30chr8

99057170

-GUK1chr1

228336365

+
5CDS-3UTRENST00000287038ENST00000366723RPL30chr8

99057170

-GUK1chr1

228336365

+
5CDS-3UTRENST00000287038ENST00000470040RPL30chr8

99057170

-GUK1chr1

228336365

+
5CDS-3UTRENST00000396070ENST00000366716RPL30chr8

99057170

-GUK1chr1

228336365

+
5CDS-3UTRENST00000396070ENST00000366718RPL30chr8

99057170

-GUK1chr1

228336365

+
5CDS-3UTRENST00000396070ENST00000366721RPL30chr8

99057170

-GUK1chr1

228336365

+
5CDS-3UTRENST00000396070ENST00000366722RPL30chr8

99057170

-GUK1chr1

228336365

+
5CDS-3UTRENST00000396070ENST00000366723RPL30chr8

99057170

-GUK1chr1

228336365

+
5CDS-3UTRENST00000396070ENST00000470040RPL30chr8

99057170

-GUK1chr1

228336365

+
5CDS-3UTRENST00000521291ENST00000366716RPL30chr8

99057170

-GUK1chr1

228336365

+
5CDS-3UTRENST00000521291ENST00000366718RPL30chr8

99057170

-GUK1chr1

228336365

+
5CDS-3UTRENST00000521291ENST00000366721RPL30chr8

99057170

-GUK1chr1

228336365

+
5CDS-3UTRENST00000521291ENST00000366722RPL30chr8

99057170

-GUK1chr1

228336365

+
5CDS-3UTRENST00000521291ENST00000366723RPL30chr8

99057170

-GUK1chr1

228336365

+
5CDS-3UTRENST00000521291ENST00000470040RPL30chr8

99057170

-GUK1chr1

228336365

+
5UTR-3CDSENST00000518164ENST00000312726RPL30chr8

99057170

-GUK1chr1

228336365

+
5UTR-3CDSENST00000518164ENST00000366726RPL30chr8

99057170

-GUK1chr1

228336365

+
5UTR-3CDSENST00000518164ENST00000366728RPL30chr8

99057170

-GUK1chr1

228336365

+
5UTR-3CDSENST00000518164ENST00000366730RPL30chr8

99057170

-GUK1chr1

228336365

+
5UTR-3CDSENST00000518164ENST00000391865RPL30chr8

99057170

-GUK1chr1

228336365

+
5UTR-3UTRENST00000518164ENST00000366716RPL30chr8

99057170

-GUK1chr1

228336365

+
5UTR-3UTRENST00000518164ENST00000366718RPL30chr8

99057170

-GUK1chr1

228336365

+
5UTR-3UTRENST00000518164ENST00000366721RPL30chr8

99057170

-GUK1chr1

228336365

+
5UTR-3UTRENST00000518164ENST00000366722RPL30chr8

99057170

-GUK1chr1

228336365

+
5UTR-3UTRENST00000518164ENST00000366723RPL30chr8

99057170

-GUK1chr1

228336365

+
5UTR-3UTRENST00000518164ENST00000470040RPL30chr8

99057170

-GUK1chr1

228336365

+
Frame-shiftENST00000287038ENST00000312726RPL30chr8

99057170

-GUK1chr1

228336365

+
Frame-shiftENST00000287038ENST00000366726RPL30chr8

99057170

-GUK1chr1

228336365

+
Frame-shiftENST00000287038ENST00000366730RPL30chr8

99057170

-GUK1chr1

228336365

+
Frame-shiftENST00000287038ENST00000391865RPL30chr8

99057170

-GUK1chr1

228336365

+
Frame-shiftENST00000396070ENST00000312726RPL30chr8

99057170

-GUK1chr1

228336365

+
Frame-shiftENST00000396070ENST00000366726RPL30chr8

99057170

-GUK1chr1

228336365

+
Frame-shiftENST00000396070ENST00000366730RPL30chr8

99057170

-GUK1chr1

228336365

+
Frame-shiftENST00000396070ENST00000391865RPL30chr8

99057170

-GUK1chr1

228336365

+
Frame-shiftENST00000521291ENST00000312726RPL30chr8

99057170

-GUK1chr1

228336365

+
Frame-shiftENST00000521291ENST00000366726RPL30chr8

99057170

-GUK1chr1

228336365

+
Frame-shiftENST00000521291ENST00000366730RPL30chr8

99057170

-GUK1chr1

228336365

+
Frame-shiftENST00000521291ENST00000391865RPL30chr8

99057170

-GUK1chr1

228336365

+
In-frameENST00000287038ENST00000366728RPL30chr8

99057170

-GUK1chr1

228336365

+
In-frameENST00000396070ENST00000366728RPL30chr8

99057170

-GUK1chr1

228336365

+
In-frameENST00000521291ENST00000366728RPL30chr8

99057170

-GUK1chr1

228336365

+
intron-3CDSENST00000523172ENST00000312726RPL30chr8

99057170

-GUK1chr1

228336365

+
intron-3CDSENST00000523172ENST00000366726RPL30chr8

99057170

-GUK1chr1

228336365

+
intron-3CDSENST00000523172ENST00000366728RPL30chr8

99057170

-GUK1chr1

228336365

+
intron-3CDSENST00000523172ENST00000366730RPL30chr8

99057170

-GUK1chr1

228336365

+
intron-3CDSENST00000523172ENST00000391865RPL30chr8

99057170

-GUK1chr1

228336365

+
intron-3UTRENST00000523172ENST00000366716RPL30chr8

99057170

-GUK1chr1

228336365

+
intron-3UTRENST00000523172ENST00000366718RPL30chr8

99057170

-GUK1chr1

228336365

+
intron-3UTRENST00000523172ENST00000366721RPL30chr8

99057170

-GUK1chr1

228336365

+
intron-3UTRENST00000523172ENST00000366722RPL30chr8

99057170

-GUK1chr1

228336365

+
intron-3UTRENST00000523172ENST00000366723RPL30chr8

99057170

-GUK1chr1

228336365

+
intron-3UTRENST00000523172ENST00000470040RPL30chr8

99057170

-GUK1chr1

228336365

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000521291RPL30chr899057170-ENST00000366728GUK1chr1228336365+60531414740485
ENST00000396070RPL30chr899057170-ENST00000366728GUK1chr1228336365+5272366932685
ENST00000287038RPL30chr899057170-ENST00000366728GUK1chr1228336365+57328211537285

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000521291ENST00000366728RPL30chr899057170-GUK1chr1228336365+0.248880460.7511195
ENST00000396070ENST00000366728RPL30chr899057170-GUK1chr1228336365+0.283871830.7161282
ENST00000287038ENST00000366728RPL30chr899057170-GUK1chr1228336365+0.231325060.7686749

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Fusion Genomic Features for RPL30-GUK1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RPL30chr899057170-GUK1chr1228336365+0.0021681080.9978319
RPL30chr899057170-GUK1chr1228336365+0.0021681080.9978319

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RPL30-GUK1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:99057170/chr1:228336365)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GUK1

Q16774

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed:31201273). Involved in the cGMP metabolism in photoreceptors (By similarity). It may also have a role in the survival and growth progression of some tumors (PubMed:31201273). In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine (PubMed:197968, PubMed:6248551, PubMed:6306664). {ECO:0000250|UniProtKB:P46195, ECO:0000269|PubMed:197968, ECO:0000269|PubMed:31201273, ECO:0000269|PubMed:6248551, ECO:0000269|PubMed:6306664}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGUK1chr8:99057170chr1:228336365ENST00000312726794_186187198.0DomainGuanylate kinase-like
TgeneGUK1chr8:99057170chr1:228336365ENST00000366716574_186187198.0DomainGuanylate kinase-like
TgeneGUK1chr8:99057170chr1:228336365ENST00000366718684_186187198.0DomainGuanylate kinase-like
TgeneGUK1chr8:99057170chr1:228336365ENST00000366726684_186187198.0DomainGuanylate kinase-like
TgeneGUK1chr8:99057170chr1:228336365ENST00000366728574_186179242.0DomainGuanylate kinase-like
TgeneGUK1chr8:99057170chr1:228336365ENST00000366730684_186187198.0DomainGuanylate kinase-like
TgeneGUK1chr8:99057170chr1:228336365ENST00000391865684_186208219.0DomainGuanylate kinase-like
TgeneGUK1chr8:99057170chr1:228336365ENST000003127267914_19187198.0Nucleotide bindingATP
TgeneGUK1chr8:99057170chr1:228336365ENST0000031272679171_172187198.0Nucleotide bindingATP
TgeneGUK1chr8:99057170chr1:228336365ENST000003127267937_51187198.0Nucleotide bindingSubstrate binding
TgeneGUK1chr8:99057170chr1:228336365ENST000003667165714_19187198.0Nucleotide bindingATP
TgeneGUK1chr8:99057170chr1:228336365ENST0000036671657171_172187198.0Nucleotide bindingATP
TgeneGUK1chr8:99057170chr1:228336365ENST000003667165737_51187198.0Nucleotide bindingSubstrate binding
TgeneGUK1chr8:99057170chr1:228336365ENST000003667186814_19187198.0Nucleotide bindingATP
TgeneGUK1chr8:99057170chr1:228336365ENST0000036671868171_172187198.0Nucleotide bindingATP
TgeneGUK1chr8:99057170chr1:228336365ENST000003667186837_51187198.0Nucleotide bindingSubstrate binding
TgeneGUK1chr8:99057170chr1:228336365ENST000003667266814_19187198.0Nucleotide bindingATP
TgeneGUK1chr8:99057170chr1:228336365ENST0000036672668171_172187198.0Nucleotide bindingATP
TgeneGUK1chr8:99057170chr1:228336365ENST000003667266837_51187198.0Nucleotide bindingSubstrate binding
TgeneGUK1chr8:99057170chr1:228336365ENST000003667285714_19179242.0Nucleotide bindingATP
TgeneGUK1chr8:99057170chr1:228336365ENST0000036672857171_172179242.0Nucleotide bindingATP
TgeneGUK1chr8:99057170chr1:228336365ENST000003667285737_51179242.0Nucleotide bindingSubstrate binding
TgeneGUK1chr8:99057170chr1:228336365ENST000003667306814_19187198.0Nucleotide bindingATP
TgeneGUK1chr8:99057170chr1:228336365ENST0000036673068171_172187198.0Nucleotide bindingATP
TgeneGUK1chr8:99057170chr1:228336365ENST000003667306837_51187198.0Nucleotide bindingSubstrate binding
TgeneGUK1chr8:99057170chr1:228336365ENST000003918656814_19208219.0Nucleotide bindingATP
TgeneGUK1chr8:99057170chr1:228336365ENST0000039186568171_172208219.0Nucleotide bindingATP
TgeneGUK1chr8:99057170chr1:228336365ENST000003918656837_51208219.0Nucleotide bindingSubstrate binding


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Fusion Gene Sequence for RPL30-GUK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>76415_76415_1_RPL30-GUK1_RPL30_chr8_99057170_ENST00000287038_GUK1_chr1_228336365_ENST00000366728_length(transcript)=573nt_BP=282nt
AGTTCCGGCTCTGCCGTGAAGAGCTTTGCATTGTGGGAAGTCTTTCCTTTCTCGTTCCCCGGCCATCTTAGCGGCTGCTGTTGGTTGGGG
GCCGTCCCGCTCCTAAGGCAGGAAGATGGTGGCCGCAAAGAAGACGAAAAAGTCGCTGGAGTCGATCAACTCTAGGCTCCAACTCGTTAT
GAAAAGTGGGAAGTACGTCCTGGGGTACAAGCAGACTCTGAAGATGATCAGACAAGGCAAAGCGAAATTGGTCATTCTCGCTAACAACTG
CCCAGCTTTGAGGAAATCAAGAAAGCTCAAAGGACCGGCGCCTGAGGCTTGCTGTCTGTTCTCGGCACCCCGGGCCCATACAGGACCAGG
GCAGCAGCATTGAGCCACCCCCTTGGCAGGCGATACGGCAGCTCTGTGCCCTTGGCCAGCATGTGGAGTGGAGGAGATGCTGCCCCTGTG
GTTGGAACATCCTGGGGTGACCCCCGACCCAGCCTCGCTGGGCTGTCCCCTGTCCCTATCTCTCACTCTGGACCCAGGGCTGACATCCTA

>76415_76415_1_RPL30-GUK1_RPL30_chr8_99057170_ENST00000287038_GUK1_chr1_228336365_ENST00000366728_length(amino acids)=85AA_BP=55

--------------------------------------------------------------
>76415_76415_2_RPL30-GUK1_RPL30_chr8_99057170_ENST00000396070_GUK1_chr1_228336365_ENST00000366728_length(transcript)=527nt_BP=236nt
CTTTCTCGTTCCCCGGCCATCTTAGCGGCTGCTGTTGGTTGGGGGCCGTCCCGCTCCTAAGGCAGGAAGATGGTGGCCGCAAAGAAGACG
AAAAAGTCGCTGGAGTCGATCAACTCTAGGCTCCAACTCGTTATGAAAAGTGGGAAGTACGTCCTGGGGTACAAGCAGACTCTGAAGATG
ATCAGACAAGGCAAAGCGAAATTGGTCATTCTCGCTAACAACTGCCCAGCTTTGAGGAAATCAAGAAAGCTCAAAGGACCGGCGCCTGAG
GCTTGCTGTCTGTTCTCGGCACCCCGGGCCCATACAGGACCAGGGCAGCAGCATTGAGCCACCCCCTTGGCAGGCGATACGGCAGCTCTG
TGCCCTTGGCCAGCATGTGGAGTGGAGGAGATGCTGCCCCTGTGGTTGGAACATCCTGGGGTGACCCCCGACCCAGCCTCGCTGGGCTGT

>76415_76415_2_RPL30-GUK1_RPL30_chr8_99057170_ENST00000396070_GUK1_chr1_228336365_ENST00000366728_length(amino acids)=85AA_BP=55

--------------------------------------------------------------
>76415_76415_3_RPL30-GUK1_RPL30_chr8_99057170_ENST00000521291_GUK1_chr1_228336365_ENST00000366728_length(transcript)=605nt_BP=314nt
GCTGTTGGTGAGTGGGCTCCTACCGACCGAGGTTTAGGCAGCGCGGGGAGCTTTGCGGGTTGCCATTTGTAACTCCGGATCCTAAAATTC
CTGTCCTGTTCTCTGTCTCTTCTAGGTTGGGGGCCGTCCCGCTCCTAAGGCAGGAAGATGGTGGCCGCAAAGAAGACGAAAAAGTCGCTG
GAGTCGATCAACTCTAGGCTCCAACTCGTTATGAAAAGTGGGAAGTACGTCCTGGGGTACAAGCAGACTCTGAAGATGATCAGACAAGGC
AAAGCGAAATTGGTCATTCTCGCTAACAACTGCCCAGCTTTGAGGAAATCAAGAAAGCTCAAAGGACCGGCGCCTGAGGCTTGCTGTCTG
TTCTCGGCACCCCGGGCCCATACAGGACCAGGGCAGCAGCATTGAGCCACCCCCTTGGCAGGCGATACGGCAGCTCTGTGCCCTTGGCCA
GCATGTGGAGTGGAGGAGATGCTGCCCCTGTGGTTGGAACATCCTGGGGTGACCCCCGACCCAGCCTCGCTGGGCTGTCCCCTGTCCCTA

>76415_76415_3_RPL30-GUK1_RPL30_chr8_99057170_ENST00000521291_GUK1_chr1_228336365_ENST00000366728_length(amino acids)=85AA_BP=55

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RPL30-GUK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RPL30-GUK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RPL30-GUK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource