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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ATL2-DHX57 (FusionGDB2 ID:7644)

Fusion Gene Summary for ATL2-DHX57

Fusion gene summary

Fusion gene information	Fusion gene name: ATL2-DHX57
	Fusion gene ID: 7644
		Hgene	Tgene
	Gene symbol	ATL2	DHX57
	Gene ID	64225	90957
	Gene name	atlastin GTPase 2	DExH-box helicase 57
	Synonyms	ARL3IP2\|ARL6IP2\|aip-2\|atlastin2	DDX57
	Cytomap	2p22.2-p22.1	2p22.1
	Type of gene	protein-coding	protein-coding
	Description	atlastin-2ADP-ribosylation factor-like protein 6-interacting protein 2ARL-6-interacting protein 2	putative ATP-dependent RNA helicase DHX57DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57DEAH box protein 57DEAH-box RNA/DNA helicase AAM73547DEAH-box helicase 57
	Modification date	20200313	20200320
	UniProtAcc	Q8NHH9	Q6P158
	Ensembl transtripts involved in fusion gene	ENST00000332337, ENST00000378954, ENST00000419554, ENST00000452935, ENST00000406122, ENST00000539122, ENST00000402054, ENST00000486927, ENST00000546051,	ENST00000295373, ENST00000479345,
Fusion gene scores	* DoF score	14 X 10 X 5=700	6 X 8 X 5=240
	# samples	16	8
	** MAII score	log2(16/700*10)=-2.12928301694497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/240*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ATL2 [Title/Abstract] AND DHX57 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ATL2(38604285)-DHX57(39030057), # samples:2
Anticipated loss of major functional domain due to fusion event.	ATL2-DHX57 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ATL2	GO:0051260	protein homooligomerization	18270207

Fusion gene breakpoints across ATL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DHX57 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-E2-A14N-01A	ATL2	chr2	38604285	-	DHX57	chr2	39030057	-
ChimerDB4	BRCA	TCGA-GI-A2C9-01A	ATL2	chr2	38604285	-	DHX57	chr2	39075544	-
ChimerDB4	STAD	TCGA-CD-8530-01A	ATL2	chr2	38570410	-	DHX57	chr2	39095553	-

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Fusion Gene ORF analysis for ATL2-DHX57

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000332337	ENST00000295373	ATL2	chr2	38570410	-	DHX57	chr2	39095553	-
5CDS-5UTR	ENST00000378954	ENST00000295373	ATL2	chr2	38570410	-	DHX57	chr2	39095553	-
5CDS-5UTR	ENST00000419554	ENST00000295373	ATL2	chr2	38570410	-	DHX57	chr2	39095553	-
5CDS-5UTR	ENST00000452935	ENST00000295373	ATL2	chr2	38570410	-	DHX57	chr2	39095553	-
5CDS-intron	ENST00000332337	ENST00000479345	ATL2	chr2	38570410	-	DHX57	chr2	39095553	-
5CDS-intron	ENST00000378954	ENST00000479345	ATL2	chr2	38604285	-	DHX57	chr2	39030057	-
5CDS-intron	ENST00000378954	ENST00000479345	ATL2	chr2	38604285	-	DHX57	chr2	39075544	-
5CDS-intron	ENST00000378954	ENST00000479345	ATL2	chr2	38570410	-	DHX57	chr2	39095553	-
5CDS-intron	ENST00000419554	ENST00000479345	ATL2	chr2	38604285	-	DHX57	chr2	39030057	-
5CDS-intron	ENST00000419554	ENST00000479345	ATL2	chr2	38604285	-	DHX57	chr2	39075544	-
5CDS-intron	ENST00000419554	ENST00000479345	ATL2	chr2	38570410	-	DHX57	chr2	39095553	-
5CDS-intron	ENST00000452935	ENST00000479345	ATL2	chr2	38570410	-	DHX57	chr2	39095553	-
5UTR-3CDS	ENST00000406122	ENST00000295373	ATL2	chr2	38604285	-	DHX57	chr2	39030057	-
5UTR-3CDS	ENST00000406122	ENST00000295373	ATL2	chr2	38604285	-	DHX57	chr2	39075544	-
5UTR-3CDS	ENST00000539122	ENST00000295373	ATL2	chr2	38604285	-	DHX57	chr2	39030057	-
5UTR-3CDS	ENST00000539122	ENST00000295373	ATL2	chr2	38604285	-	DHX57	chr2	39075544	-
5UTR-intron	ENST00000406122	ENST00000479345	ATL2	chr2	38604285	-	DHX57	chr2	39030057	-
5UTR-intron	ENST00000406122	ENST00000479345	ATL2	chr2	38604285	-	DHX57	chr2	39075544	-
5UTR-intron	ENST00000539122	ENST00000479345	ATL2	chr2	38604285	-	DHX57	chr2	39030057	-
5UTR-intron	ENST00000539122	ENST00000479345	ATL2	chr2	38604285	-	DHX57	chr2	39075544	-
Frame-shift	ENST00000378954	ENST00000295373	ATL2	chr2	38604285	-	DHX57	chr2	39075544	-
Frame-shift	ENST00000419554	ENST00000295373	ATL2	chr2	38604285	-	DHX57	chr2	39075544	-
In-frame	ENST00000378954	ENST00000295373	ATL2	chr2	38604285	-	DHX57	chr2	39030057	-
In-frame	ENST00000419554	ENST00000295373	ATL2	chr2	38604285	-	DHX57	chr2	39030057	-
intron-3CDS	ENST00000332337	ENST00000295373	ATL2	chr2	38604285	-	DHX57	chr2	39030057	-
intron-3CDS	ENST00000332337	ENST00000295373	ATL2	chr2	38604285	-	DHX57	chr2	39075544	-
intron-3CDS	ENST00000402054	ENST00000295373	ATL2	chr2	38604285	-	DHX57	chr2	39030057	-
intron-3CDS	ENST00000402054	ENST00000295373	ATL2	chr2	38604285	-	DHX57	chr2	39075544	-
intron-3CDS	ENST00000452935	ENST00000295373	ATL2	chr2	38604285	-	DHX57	chr2	39030057	-
intron-3CDS	ENST00000452935	ENST00000295373	ATL2	chr2	38604285	-	DHX57	chr2	39075544	-
intron-3CDS	ENST00000486927	ENST00000295373	ATL2	chr2	38604285	-	DHX57	chr2	39030057	-
intron-3CDS	ENST00000486927	ENST00000295373	ATL2	chr2	38604285	-	DHX57	chr2	39075544	-
intron-3CDS	ENST00000546051	ENST00000295373	ATL2	chr2	38604285	-	DHX57	chr2	39030057	-
intron-3CDS	ENST00000546051	ENST00000295373	ATL2	chr2	38604285	-	DHX57	chr2	39075544	-
intron-5UTR	ENST00000402054	ENST00000295373	ATL2	chr2	38570410	-	DHX57	chr2	39095553	-
intron-5UTR	ENST00000406122	ENST00000295373	ATL2	chr2	38570410	-	DHX57	chr2	39095553	-
intron-5UTR	ENST00000486927	ENST00000295373	ATL2	chr2	38570410	-	DHX57	chr2	39095553	-
intron-5UTR	ENST00000539122	ENST00000295373	ATL2	chr2	38570410	-	DHX57	chr2	39095553	-
intron-5UTR	ENST00000546051	ENST00000295373	ATL2	chr2	38570410	-	DHX57	chr2	39095553	-
intron-intron	ENST00000332337	ENST00000479345	ATL2	chr2	38604285	-	DHX57	chr2	39030057	-
intron-intron	ENST00000332337	ENST00000479345	ATL2	chr2	38604285	-	DHX57	chr2	39075544	-
intron-intron	ENST00000402054	ENST00000479345	ATL2	chr2	38604285	-	DHX57	chr2	39030057	-
intron-intron	ENST00000402054	ENST00000479345	ATL2	chr2	38604285	-	DHX57	chr2	39075544	-
intron-intron	ENST00000402054	ENST00000479345	ATL2	chr2	38570410	-	DHX57	chr2	39095553	-
intron-intron	ENST00000406122	ENST00000479345	ATL2	chr2	38570410	-	DHX57	chr2	39095553	-
intron-intron	ENST00000452935	ENST00000479345	ATL2	chr2	38604285	-	DHX57	chr2	39030057	-
intron-intron	ENST00000452935	ENST00000479345	ATL2	chr2	38604285	-	DHX57	chr2	39075544	-
intron-intron	ENST00000486927	ENST00000479345	ATL2	chr2	38604285	-	DHX57	chr2	39030057	-
intron-intron	ENST00000486927	ENST00000479345	ATL2	chr2	38604285	-	DHX57	chr2	39075544	-
intron-intron	ENST00000486927	ENST00000479345	ATL2	chr2	38570410	-	DHX57	chr2	39095553	-
intron-intron	ENST00000539122	ENST00000479345	ATL2	chr2	38570410	-	DHX57	chr2	39095553	-
intron-intron	ENST00000546051	ENST00000479345	ATL2	chr2	38604285	-	DHX57	chr2	39030057	-
intron-intron	ENST00000546051	ENST00000479345	ATL2	chr2	38604285	-	DHX57	chr2	39075544	-
intron-intron	ENST00000546051	ENST00000479345	ATL2	chr2	38570410	-	DHX57	chr2	39095553	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000378954	ATL2	chr2	38604285	-	ENST00000295373	DHX57	chr2	39030057	-	1035	120	461	90	123
ENST00000419554	ATL2	chr2	38604285	-	ENST00000295373	DHX57	chr2	39030057	-	1046	131	472	101	123

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000378954	ENST00000295373	ATL2	chr2	38604285	-	DHX57	chr2	39030057	-	0.43437737	0.5656226
ENST00000419554	ENST00000295373	ATL2	chr2	38604285	-	DHX57	chr2	39030057	-	0.4594492	0.5405508

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Fusion Genomic Features for ATL2-DHX57

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ATL2-DHX57

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:38604285/chr2:39030057)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ATL2 Q8NHH9	DHX57 Q6P158
FUNCTION: GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (PubMed:18270207, PubMed:19665976, PubMed:27619977). {ECO:0000269\|PubMed:18270207, ECO:0000269\|PubMed:19665976, ECO:0000269\|PubMed:27619977}.	FUNCTION: Probable ATP-binding RNA helicase.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000332337

256_284

567.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000378954

256_284

584.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000402054

256_284

413.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000419554

256_284

580.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000539122

256_284

413.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000332337

91_336

567.0

Domain

GB1/RHD3-type G

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000378954

91_336

584.0

Domain

GB1/RHD3-type G

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000402054

91_336

413.0

Domain

GB1/RHD3-type G

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000419554

91_336

580.0

Domain

GB1/RHD3-type G

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000539122

91_336

413.0

Domain

GB1/RHD3-type G

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000332337

101_108

567.0

Nucleotide binding

GTP

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000332337

145_147

567.0

Nucleotide binding

GTP

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000332337

244_245

567.0

Nucleotide binding

GTP

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000332337

303_306

567.0

Nucleotide binding

GTP

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000378954

101_108

584.0

Nucleotide binding

GTP

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000378954

145_147

584.0

Nucleotide binding

GTP

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000378954

244_245

584.0

Nucleotide binding

GTP

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000378954

303_306

584.0

Nucleotide binding

GTP

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000402054

101_108

413.0

Nucleotide binding

GTP

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000402054

145_147

413.0

Nucleotide binding

GTP

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000402054

244_245

413.0

Nucleotide binding

GTP

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000402054

303_306

413.0

Nucleotide binding

GTP

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000419554

101_108

580.0

Nucleotide binding

GTP

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000419554

145_147

580.0

Nucleotide binding

GTP

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000419554

244_245

580.0

Nucleotide binding

GTP

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000419554

303_306

580.0

Nucleotide binding

GTP

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000539122

101_108

413.0

Nucleotide binding

GTP

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000539122

145_147

413.0

Nucleotide binding

GTP

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000539122

244_245

413.0

Nucleotide binding

GTP

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000539122

303_306

413.0

Nucleotide binding

GTP

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000332337

1_476

567.0

Topological domain

Cytoplasmic

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000332337

498_499

567.0

Topological domain

Lumenal

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000332337

521_583

567.0

Topological domain

Cytoplasmic

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000378954

1_476

584.0

Topological domain

Cytoplasmic

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000378954

498_499

584.0

Topological domain

Lumenal

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000378954

521_583

584.0

Topological domain

Cytoplasmic

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000402054

1_476

413.0

Topological domain

Cytoplasmic

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000402054

498_499

413.0

Topological domain

Lumenal

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000402054

521_583

413.0

Topological domain

Cytoplasmic

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000419554

1_476

580.0

Topological domain

Cytoplasmic

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000419554

498_499

580.0

Topological domain

Lumenal

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000419554

521_583

580.0

Topological domain

Cytoplasmic

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000539122

1_476

413.0

Topological domain

Cytoplasmic

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000539122

498_499

413.0

Topological domain

Lumenal

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000539122

521_583

413.0

Topological domain

Cytoplasmic

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000332337

477_497

567.0

Transmembrane

Helical

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000332337

500_520

567.0

Transmembrane

Helical

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000378954

477_497

584.0

Transmembrane

Helical

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000378954

500_520

584.0

Transmembrane

Helical

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000402054

477_497

413.0

Transmembrane

Helical

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000402054

500_520

413.0

Transmembrane

Helical

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000419554

477_497

580.0

Transmembrane

Helical

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000419554

500_520

580.0

Transmembrane

Helical

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000539122

477_497

413.0

Transmembrane

Helical

Hgene

ATL2

chr2:38604285

chr2:39030057

ENST00000539122

500_520

413.0

Transmembrane

Helical

Tgene

DHX57

chr2:38604285

chr2:39030057

ENST00000295373

101_125

1272

1387.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DHX57

chr2:38604285

chr2:39030057

ENST00000295373

9_49

1272

1387.0

Compositional bias

Note=Gly-rich

Tgene

DHX57

chr2:38604285

chr2:39030057

ENST00000295373

180_220

1272

1387.0

Domain

UBA

Tgene

DHX57

chr2:38604285

chr2:39030057

ENST00000295373

554_721

1272

1387.0

Domain

Helicase ATP-binding

Tgene

DHX57

chr2:38604285

chr2:39030057

ENST00000295373

830_1010

1272

1387.0

Domain

Helicase C-terminal

Tgene

DHX57

chr2:38604285

chr2:39030057

ENST00000295373

668_671

1272

1387.0

Motif

Note=DEVH box

Tgene

DHX57

chr2:38604285

chr2:39030057

ENST00000295373

567_574

1272

1387.0

Nucleotide binding

ATP

Tgene

DHX57

chr2:38604285

chr2:39030057

ENST00000295373

299_326

1272

1387.0

Zinc finger

C3H1-type

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Fusion Gene Sequence for ATL2-DHX57

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>7644_7644_1_ATL2-DHX57_ATL2_chr2_38604285_ENST00000378954_DHX57_chr2_39030057_ENST00000295373_length(transcript)=1035nt_BP=120nt
AGATGGCGGAGGGGGACGAGGCAGCGCGAGGGCAGCAACCGCACCAGGGGCTGTGGCGCCGGCGACGGACCAGCGACCCAAGCGCCGCGG
TTAACCACGTCTCGTCCACGACCTCCCTAGGTGAGACACTTTGACAGCCCCTACCTGTTGTACCACGAGAAGATAAAAACTAGTCGAGTA
TTCATCCGAGACTGCAGCATGGTGTCTGTGTACCCGCTGGTCTTGTTTGGAGGAGGCCAAGTGAATGTGCAGCTTCAAAGAGGAGAGTTC
GTTGTCTCCCTGGATGATGGTTGGATCCGTTTTGTAGCTGCTTCCCATCAGGTGGCTGAACTGGTAAAGGAGCTTCGTTGCGAACTTGAT
CAGCTTCTCCAGGATAAAATTAAAAACCCAAGCATTGATCTGTGTACGTGTCCTCGAGGATCCCGGATCATCAGCACAATTGTGAAACTT
GTCACCACACAATAAAAAGCAGTCTTAGAGAGTGCTTGCTACTCACCTGCTTCTAGCTCACCTGGGAAATAACAGCAGAACCTCTACCTC
GAACTAAAGACCTATTGGGGCTGGCCCTGGTGGAGGAGCCCAGGGCATGAAGCCCAAGGCAGCTGAGGCAGTGTATATACCCTTAGGGCC
ATTTCTAACAAAGCCTTGGCCACTCCCAGCACAATTTGGAGTGTCAAGGGTGAGAGCCTAAAACCCAGCTTGCCTGTCTTTGTCTCTGTG
ATTGTTCTGGAGTGAATTAAGTTCACCTGATAACTCAAAAGTGAATGTATAATACAATTCTGTTTTAATCTGTGTATTCTTTTTCTCCTA
CTTTTTACTGGGGTGAGAGGGGCATGAAGAGAAATACGCCTTTTTTTTTTTTCTTTTCCTGTCGCCAAGGCTCGACTGAGAGAAGTCAGA
ACAGAGAAGGGGAAAAAAAACCCAAAATTATGTGAACAAGCAAAATTAAAATTTCATTTTAGGCTATTGGCTACTGAGTAAACTTGACTT

>7644_7644_1_ATL2-DHX57_ATL2_chr2_38604285_ENST00000378954_DHX57_chr2_39030057_ENST00000295373_length(amino acids)=123AA_BP=1
MCGDKFHNCADDPGSSRTRTQINAWVFNFILEKLIKFATKLLYQFSHLMGSSYKTDPTIIQGDNELSSLKLHIHLASSKQDQRVHRHHAA

--------------------------------------------------------------
>7644_7644_2_ATL2-DHX57_ATL2_chr2_38604285_ENST00000419554_DHX57_chr2_39030057_ENST00000295373_length(transcript)=1046nt_BP=131nt
AAATCGGTACAAGATGGCGGAGGGGGACGAGGCAGCGCGAGGGCAGCAACCGCACCAGGGGCTGTGGCGCCGGCGACGGACCAGCGACCC
AAGCGCCGCGGTTAACCACGTCTCGTCCACGACCTCCCTAGGTGAGACACTTTGACAGCCCCTACCTGTTGTACCACGAGAAGATAAAAA
CTAGTCGAGTATTCATCCGAGACTGCAGCATGGTGTCTGTGTACCCGCTGGTCTTGTTTGGAGGAGGCCAAGTGAATGTGCAGCTTCAAA
GAGGAGAGTTCGTTGTCTCCCTGGATGATGGTTGGATCCGTTTTGTAGCTGCTTCCCATCAGGTGGCTGAACTGGTAAAGGAGCTTCGTT
GCGAACTTGATCAGCTTCTCCAGGATAAAATTAAAAACCCAAGCATTGATCTGTGTACGTGTCCTCGAGGATCCCGGATCATCAGCACAA
TTGTGAAACTTGTCACCACACAATAAAAAGCAGTCTTAGAGAGTGCTTGCTACTCACCTGCTTCTAGCTCACCTGGGAAATAACAGCAGA
ACCTCTACCTCGAACTAAAGACCTATTGGGGCTGGCCCTGGTGGAGGAGCCCAGGGCATGAAGCCCAAGGCAGCTGAGGCAGTGTATATA
CCCTTAGGGCCATTTCTAACAAAGCCTTGGCCACTCCCAGCACAATTTGGAGTGTCAAGGGTGAGAGCCTAAAACCCAGCTTGCCTGTCT
TTGTCTCTGTGATTGTTCTGGAGTGAATTAAGTTCACCTGATAACTCAAAAGTGAATGTATAATACAATTCTGTTTTAATCTGTGTATTC
TTTTTCTCCTACTTTTTACTGGGGTGAGAGGGGCATGAAGAGAAATACGCCTTTTTTTTTTTTCTTTTCCTGTCGCCAAGGCTCGACTGA
GAGAAGTCAGAACAGAGAAGGGGAAAAAAAACCCAAAATTATGTGAACAAGCAAAATTAAAATTTCATTTTAGGCTATTGGCTACTGAGT

>7644_7644_2_ATL2-DHX57_ATL2_chr2_38604285_ENST00000419554_DHX57_chr2_39030057_ENST00000295373_length(amino acids)=123AA_BP=1
MCGDKFHNCADDPGSSRTRTQINAWVFNFILEKLIKFATKLLYQFSHLMGSSYKTDPTIIQGDNELSSLKLHIHLASSKQDQRVHRHHAA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ATL2-DHX57

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ATL2-DHX57

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ATL2-DHX57

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source