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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ATL3-ZDHHC14 (FusionGDB2 ID:7656)

Fusion Gene Summary for ATL3-ZDHHC14

Fusion gene summary

Fusion gene information	Fusion gene name: ATL3-ZDHHC14
	Fusion gene ID: 7656
		Hgene	Tgene
	Gene symbol	ATL3	ZDHHC14
	Gene ID	25923	79683
	Gene name	atlastin GTPase 3	zinc finger DHHC-type palmitoyltransferase 14
	Synonyms	HSN1F	NEW1CP
	Cytomap	11q13.1	6q25.3
	Type of gene	protein-coding	protein-coding
	Description	atlastin-3	probable palmitoyltransferase ZDHHC14DHHC-14NEW1 domain-containing proteinzinc finger DHHC domain-containing protein 14zinc finger DHHC-type containing 14zinc finger, DHHC domain containing 14
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000332645, ENST00000398868, ENST00000535789, ENST00000538786,	ENST00000341375, ENST00000359775, ENST00000414563,
Fusion gene scores	* DoF score	6 X 7 X 3=126	11 X 12 X 9=1188
	# samples	7	16
	** MAII score	log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/1188*10)=-2.8923910259134 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ATL3 [Title/Abstract] AND ZDHHC14 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ATL3(63438762)-ZDHHC14(158068291), # samples:3
Anticipated loss of major functional domain due to fusion event.	ATL3-ZDHHC14 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. ATL3-ZDHHC14 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ATL3	GO:0051260	protein homooligomerization	18270207
Tgene	ZDHHC14	GO:0018345	protein palmitoylation	23034182

Fusion gene breakpoints across ATL3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ZDHHC14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-BF-A1Q0-01A	ATL3	chr11	63438762	-	ZDHHC14	chr6	158068291	+

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Fusion Gene ORF analysis for ATL3-ZDHHC14

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000332645	ENST00000341375	ATL3	chr11	63438762	-	ZDHHC14	chr6	158068291	+
5CDS-3UTR	ENST00000398868	ENST00000341375	ATL3	chr11	63438762	-	ZDHHC14	chr6	158068291	+
5UTR-3CDS	ENST00000535789	ENST00000359775	ATL3	chr11	63438762	-	ZDHHC14	chr6	158068291	+
5UTR-3CDS	ENST00000535789	ENST00000414563	ATL3	chr11	63438762	-	ZDHHC14	chr6	158068291	+
5UTR-3UTR	ENST00000535789	ENST00000341375	ATL3	chr11	63438762	-	ZDHHC14	chr6	158068291	+
Frame-shift	ENST00000332645	ENST00000359775	ATL3	chr11	63438762	-	ZDHHC14	chr6	158068291	+
Frame-shift	ENST00000332645	ENST00000414563	ATL3	chr11	63438762	-	ZDHHC14	chr6	158068291	+
In-frame	ENST00000398868	ENST00000359775	ATL3	chr11	63438762	-	ZDHHC14	chr6	158068291	+
In-frame	ENST00000398868	ENST00000414563	ATL3	chr11	63438762	-	ZDHHC14	chr6	158068291	+
intron-3CDS	ENST00000538786	ENST00000359775	ATL3	chr11	63438762	-	ZDHHC14	chr6	158068291	+
intron-3CDS	ENST00000538786	ENST00000414563	ATL3	chr11	63438762	-	ZDHHC14	chr6	158068291	+
intron-3UTR	ENST00000538786	ENST00000341375	ATL3	chr11	63438762	-	ZDHHC14	chr6	158068291	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000398868

ATL3

chr11

63438762

ENST00000414563

ZDHHC14

chr6

158068291

1713

323

260

889

209

ENST00000398868

ATL3

chr11

63438762

ENST00000359775

ZDHHC14

chr6

158068291

5959

323

260

934

224

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000398868	ENST00000414563	ATL3	chr11	63438762	-	ZDHHC14	chr6	158068291	+	0.41913378	0.5808662
ENST00000398868	ENST00000359775	ATL3	chr11	63438762	-	ZDHHC14	chr6	158068291	+	0.20349185	0.79650813

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Fusion Genomic Features for ATL3-ZDHHC14

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ATL3	chr11	63438761	-	ZDHHC14	chr6	158068290	+	0.011120613	0.9888793
ATL3	chr11	63438761	-	ZDHHC14	chr6	158068290	+	0.011120613	0.9888793

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ATL3-ZDHHC14

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:63438762/chr6:158068291)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ATL3

chr11:63438762

chr6:158068291

ENST00000398868

57_305

542.0

Domain

GB1/RHD3-type G

Hgene

ATL3

chr11:63438762

chr6:158068291

ENST00000398868

114_116

542.0

Nucleotide binding

GTP

Hgene

ATL3

chr11:63438762

chr6:158068291

ENST00000398868

213_214

542.0

Nucleotide binding

GTP

Hgene

ATL3

chr11:63438762

chr6:158068291

ENST00000398868

272_275

542.0

Nucleotide binding

GTP

Hgene

ATL3

chr11:63438762

chr6:158068291

ENST00000398868

67_74

542.0

Nucleotide binding

GTP

Hgene

ATL3

chr11:63438762

chr6:158068291

ENST00000398868

1_445

542.0

Topological domain

Cytoplasmic

Hgene

ATL3

chr11:63438762

chr6:158068291

ENST00000398868

467_467

542.0

Topological domain

Lumenal

Hgene

ATL3

chr11:63438762

chr6:158068291

ENST00000398868

489_541

542.0

Topological domain

Cytoplasmic

Hgene

ATL3

chr11:63438762

chr6:158068291

ENST00000398868

446_466

542.0

Transmembrane

Helical

Hgene

ATL3

chr11:63438762

chr6:158068291

ENST00000398868

468_488

542.0

Transmembrane

Helical

Tgene

ZDHHC14

chr11:63438762

chr6:158068291

ENST00000359775

165_215

285

489.0

Domain

DHHC

Tgene

ZDHHC14

chr11:63438762

chr6:158068291

ENST00000414563

165_215

285

474.0

Domain

DHHC

Tgene

ZDHHC14

chr11:63438762

chr6:158068291

ENST00000359775

111_208

285

489.0

Topological domain

Cytoplasmic

Tgene

ZDHHC14

chr11:63438762

chr6:158068291

ENST00000359775

1_60

285

489.0

Topological domain

Cytoplasmic

Tgene

ZDHHC14

chr11:63438762

chr6:158068291

ENST00000359775

230_255

285

489.0

Topological domain

Lumenal

Tgene

ZDHHC14

chr11:63438762

chr6:158068291

ENST00000359775

277_488

285

489.0

Topological domain

Cytoplasmic

Tgene

ZDHHC14

chr11:63438762

chr6:158068291

ENST00000359775

82_89

285

489.0

Topological domain

Lumenal

Tgene

ZDHHC14

chr11:63438762

chr6:158068291

ENST00000414563

111_208

285

474.0

Topological domain

Cytoplasmic

Tgene

ZDHHC14

chr11:63438762

chr6:158068291

ENST00000414563

1_60

285

474.0

Topological domain

Cytoplasmic

Tgene

ZDHHC14

chr11:63438762

chr6:158068291

ENST00000414563

230_255

285

474.0

Topological domain

Lumenal

Tgene

ZDHHC14

chr11:63438762

chr6:158068291

ENST00000414563

277_488

285

474.0

Topological domain

Cytoplasmic

Tgene

ZDHHC14

chr11:63438762

chr6:158068291

ENST00000414563

82_89

285

474.0

Topological domain

Lumenal

Tgene

ZDHHC14

chr11:63438762

chr6:158068291

ENST00000359775

209_229

285

489.0

Transmembrane

Helical

Tgene

ZDHHC14

chr11:63438762

chr6:158068291

ENST00000359775

256_276

285

489.0

Transmembrane

Helical

Tgene

ZDHHC14

chr11:63438762

chr6:158068291

ENST00000359775

61_81

285

489.0

Transmembrane

Helical

Tgene

ZDHHC14

chr11:63438762

chr6:158068291

ENST00000359775

90_110

285

489.0

Transmembrane

Helical

Tgene

ZDHHC14

chr11:63438762

chr6:158068291

ENST00000414563

209_229

285

474.0

Transmembrane

Helical

Tgene

ZDHHC14

chr11:63438762

chr6:158068291

ENST00000414563

256_276

285

474.0

Transmembrane

Helical

Tgene

ZDHHC14

chr11:63438762

chr6:158068291

ENST00000414563

61_81

285

474.0

Transmembrane

Helical

Tgene

ZDHHC14

chr11:63438762

chr6:158068291

ENST00000414563

90_110

285

474.0

Transmembrane

Helical

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Fusion Gene Sequence for ATL3-ZDHHC14

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>7656_7656_1_ATL3-ZDHHC14_ATL3_chr11_63438762_ENST00000398868_ZDHHC14_chr6_158068291_ENST00000359775_length(transcript)=5959nt_BP=323nt
ACACGCGGCAGGCGGTGGCGGGATTCTGCCGCGTGCGCTTTCCCGCCCCGCCTCGCCTAGCCTCGTCCTGCGCTCGCCACGCCTCGGGCT
GTCCGTTGGGCCACGCAGACCGCGCTGCGCTCGCTCCGTCGCGGCTCCGCGTGCCCCACCTTCTGGCTAGTTTTTTCTAGAGCCCAGGCT
CCGCCCGTTTCCCGCTTCCAGGGCCCGGTTCGTTCCCGCCCGCACCCGTCCCTCTCCTCTGCACCCCTGCTGCTTCTGCTTTGAAGGCGG
AGGCTCCATGTTGTCCCCTCAGCGAGTGGCAGCAGCTGCCTCAAGAGGAGCAGATTAAAGGATCCTGGTCAAATAAAAGAGGTAAAGAAA
ATTACAATCCCTACAGCTACGGAAATATCTTTACCAACTGCTGTGTTGCCCTGTGTGGGCCCATCTCACCAAGCCTGATCGACAGAAGAG
GGTACATCCAGCCCGACACGCCGCAGCCAGCAGCACCCTCCAATGGCATCACCATGTACGGGGCCACGCAGTCACAGAGTGACATGTGCG
ACCAAGACCAGTGCATTCAGAGCACCAAATTCGTTTTGCAGGCTGCAGCCACGCCCCTGCTGCAGAGCGAGCCCAGCCTCACCAGCGACG
AGCTGCACCTGCCCGGGAAGCCTGGCCTGGGCACGCCCTGCGCCAGCCTCACACTGGGCCCGCCCACACCGCCCGCCTCCATGCCCAACC
TCGCCGAGGCCACGCTCGCGGACGTGATGCCCCGGAAAGATGAGCACATGGGCCACCAGTTCCTGACGCCCGATGAGGCGCCCTCGCCCC
CCAGGCTACTGGCGGCGGGCAGCCCCCTGGCGCACAGCCGCACCATGCACGTGCTGGGCCTGGCCAGCCAGGACTCCCTGCATGAGGACT
CTGTGCGCGGCCTGGTGAAGCTCAGCTCCGTGTGACCCACATGGCCCCAGGCCGGGGGACACCAGAGGCTCCTCCATGGGCAGCAGGAGT
GAGCGGAGGGGTGTGTCCCACAGCGACTTTCCCAGCCAATGCCACGGTGGAGATGACAGCCCCAGGTCTGGGGTACAGAGACCACTTAGG
ATGGCACAGGGTGGCTGGCCCCGGATGCTGAGAGCTTGGTTTCATTTGAATTTTCTTCCCCAACCTGAGTGCTTTGACAACAATGGAAAT
AGAGAAGTGGCTGCTTTCTTTTGGTGACCCTCCAGGGGTGGAATCGGAGTGTGTCTGCCCGCCCTTGTGACAGACACACGGAAGGCTTCT
GACGCTTGTGGCCAGACTGCAATTGCACTTATGTGTTATGCTACTAATATTTGAAACAGACCTGCCATTCCATTTGTTAATTAAAAAAAA
AAAAAATCCTAAAGGGAAAAAACCGACCAGGTGTGGATCTGCATGCCACGCTGCCGTCTGTGTTACAGTGGTGTTGCTATTTCCAAGGAA
GTGCTGCTTTCTTTTTCTTTTTTTAATTTTGTGAATTTTCAAGTGCTGTTTTGTTGGAAGACAGTGCAACGAACTGAGACTAATGGACAG
TGTCATCACTCAGCTTACTGGGCTGAGGCGTCTGTGGAGAGGTGGCACCGGGGCTGCAGAGGGCGGCTGGGGTTCCGTCGTGTCGGGTGT
CACTTCACCTTCTGTTTGGCCGCTCGATGAGGTCTCGTGTTGAGATATTGTGTGCCACAACCCCCACAGTCTTCACCTCCGTGTGTGATG
AAACTTCCCGTGGACAGCCAATAAAATGACGTCCTCTGTTATTTTGGATCTGCGTACGGTTATCCTTAATAGCATAAATGAAAACAAAGT
CATCCAGATGGGGAGAGTTTTTCTTGAAATGTCCCTAGCGAGGAATGGTCCCCAGACAACCAAAAGTCAAATCTTTGAACTGGGAGATAT
TTATAGAATAATTTCTTAGATAAGAGGCAAGTTTTCCATCATTTATTTTCTTTAATTATCTCTTTTTGACACCATCTTAGTGGAATTTGC
TCTACGTTTGCAGTTTGCCGTGCAACAGTTGATCGGAAGTAGGGAGAGGGGAGGGGACGCTCAGGGAGAAGGTTCTGTCGGGCGTCTTCT
GGGCTTCCTTCTGTGTTAACGTGTCACTCAATCCCAGAAGTGCAACTTGAGGTCCTAGTAAAGGTATCAGAAAATGAGGAGGAGAAATCG
GCTTACAGTCTAAGCTGAGATCATGTAGGTCATCATCCTTCCTAGACACTGATCAGAATGAAATTAAGAAAATGACCACTTTGTTCACTT
TCATTGGTCACCTAGAAGGGAACGAACTGGCTCTGGACTTAGGGAGTGTGTCACTATGGGGGCAGCCACAGGGGACACAGCAACTCCTCT
CCTGGCTTCTTTCCAGACCATAAATCTAACAGCTAAAGCTACTCAAGTTCAAAGCCATGGCCTTGCTCCTTATAACCATATGAAAGACAA
GACACATTGACCAATGATACAAGTAACCCAAGTGATTTGCATTTATGGAAAAAGGCTATTACTCCTGAGAAAGAGTTGCCATTTTATATA
AAAGAAAAGAAGATAGGAAAAAGAAAAGCACACAAGTTTTATTTGGAATGAAGGCAATTCACAGGTCACAAAATAATTCATGCTGAAAGG
GCCTGCAGAGTTCTTGCACTGTGATGTCTTCGAGCCATCTTTATTGTCATGCTGCATGCACGTATAGAAAATGGAATAGGTCCATTCTAT
GTAGCCATTTTTGATTTTCTGAACCACCTAACTACTTGTACCCACCTGCAATGTGTAATTCATGGGGCAGTGCCCTCCTTACACAACCGC
ACACGCTCACAGGCACCAACTCACAGGGATTCTCCTTGTCCACGCTACCTGTGAGCCCAAAGTGACAGCCCCACAAAGGAGCTTCCACAA
CTTCCCAAACCGTCTCTGCTCCTTGCTTTCTTCCACCTGCTCCCCAGAGGCCCCAGGAAGGAGTTGGCCCTGATGAGAACGGTGCTCCAT
GGGTGACCGCGAATCCGGCTTAGCCCTCACTCCGGTCCCACGTGTGGCCCAGTCCATTCTCAGCTCATTCCCCTGGAAAGCAAGATCATG
GTCTTCAGAGGCCTCCCGCTTCTAACATTTCCTAACTCAGTGGTTGCCACTCTCCTGTGACCAGCCCTTCTTCCCACCTCACTGTGAAAA
ATTCCCAGAAGCCAGGATCACGACTCACTTGTCTTCACATAATGGATATTTACTTAATATTTATTATCAATTTCCCCACCTCCAACCCTG
TCCCTGGCACACACTTGGCATCATTTATCCAATAGGGGACTGGGAATTTTGGTGAAGTGAATCAAGGCTATTCAGGGTCAAGAGAGAGAT
TAACTTGAATGGGCCAATTTGCTAGATAATTAATGTCTTAAAAACCAAAACCAGAGAGAAGCCCACAGCCCTGTCCTCTGTGGCTTGAAA
AAGAAACCCAGCATCAGAGGAATGAGCGATGATGCCCCCTGGGGCGCCCACTTCTGTTTGTCAGGAGGGATGGTCGGAGGGGCAGCTCAC
CTGGCGAGGTGATGGCTCTGCATTTCCCACGAACATATATGTGACATGTACATAAATATAAATACTTATGTTTATAAATGTTGAATGGTT
CCTTCTAGCTGTGGCTGAGTAGACGTTGGTGTTTCTAACTTCTTTCAGTGTGTTAGAGATTGATTACATGCTAGCTATAAAAAGTAAAAT
AAATATTTTACCATGCTATTAAAGCTTGGACCATTATCAAACACACACAAACACACACTCATTCTGCTGTTTAAAAATTCATCTGCGTTC
GTTCTCCCAGGAGTGCTCCAGGGAACCACAGGCTTCCCGGCACTTGAAGGCTGAACTGAGCGTGAGTGCCCTGGTCCCCAGGAAGCAGGC
GGATGCTGCAGGAAGGTGGCAGACAGCCTGCATCCAGGAGGGCCCCAGGAAGTGGGGATGCTGCAGGAAGGCGGCACAAAGCCTGCATCC
GGGAGGGCCCCAGGAAGCAGGGGGATGCTGCAGGAAGGTGGCAGACAGACTGCATCCAGGAGGGCACAGTGACCTGTCACTCCGTTCTGC
AGAAATTGGCCCAGCAGTTGCGTTATGCCCAACCAAAAGATGCTCGTTCCAGCTTTCAAATGTGATGATTTCAGCCTGTGAGGACAATGC
CATGTCCCCACCCTAAGCCAGCAAAATGCGAAATCTCTGTTCTGGCCCAGAATGGCACAAGGGAGGAGTCTTTGCAGAGTTCCACGCCAC
CCCCCAGCTTACTGCGGCCTTCACCGGCTCTGTCTAGGATTGCCAGCTGTGGTTCCAAGTGAGGAGCAAACCCATTTTATGAGCCATGTT
CCTGCGGAGACCTGATGGGCCAGGCCTTCTGTGGCTTTGAAAACCCCTAAGCTCTTCACCTCCTGGGCCTAGGCCTTCTTGTCTGACTCA
ACAGCAAGAAAAATGAACTTGCCAAAATTGGCAGTAGGTGTCCTTGACACAGGGGCTTCTGATGGCATCGCCCAGAAAATGCTGGAACCA
GAACTGGTCAGAGACTTTGAAGGGCACAGCCTGGCGGGCTACTCCCCAAGGGTCTCAGGTCTCTGCCCACCTGACTACCCTGCAGCAAAC
GCTTCTCTGTAACCTGACTTCTCCCTTCAGACCTCAGCCTACAACCATCCTCTTCATGCCAGGAACCAACTGCTTCTCAGCCTCGGCTTA
GGGTCTTAAGTTCACCAGAAGGGATCGGGGTTTGCGTTGATATTATAAGGAATCTTCCCAGAAGGAGCTGCCCTTCATCCATCCACAAGA
ATACATTGAGTTCATTTAGTTCTTGACCAGGTAAGAAAAGAATAAAGGAGAACAAATATTAAATACTCTTTTCTAATTGATGCCTTACTA
CTGTTTTGAAGCTGAGCCGAAATCAAATTGATGTTTACATTTTCTATCAAGTACACATGAGCTGTGGGAGTCTAGCATATTCTTGTCCAA
AAGAGAGAGACTTTCAAATGAATTCCTATTCCTCTTGGTCCCCTCCACCTATTTTGGAGGTCTGCATGTGGAGTTGTATGCTATTTTCCA
AGGTACCTCATTTAAAAAAAAAAAAAAAAAAAAACTGCCTCTCATTTGTTCCCTTAAAACGTCTCTCTCTCTCATAAAACTAAGTTATCA
TTGAAATATTAAACGATCTGAAGCGTCTTTTTTTTTTTCAAATAAATGTCAAAGATGGTAATAGTTTGTAAATCAGTAAATCCTCTGTCC
ATCTGCCCATTGTCCATGGTCCTGATAATAGAGCCAAGATGGATTTTCACATGTAAGGTGTTAGTCCATTAATCCAGCCATTAAAAGTAG
TTGGGAGATTGAAGATTAGATGGTTTCTGGAGCAACCGAATTTGCAGCTGCCACAAAACTAGATAAATAGCCACAACTGGAGTTATTTTT
TGATCTCATAAACCCCAGGAATTACACACAGAATGGATTGAAAAGCAGACAAGCATCTTGTGCTATTGCAGAGACTTTTCTACCCAGGAA
GTGTTGAATTTTTAAAAGAAACTTGATATTGGTGATAAAGGTATGAATGAACAACTCTCTTACTTGCCCTCGATGTTTCAAGATGCCTGG
TGAAACCGAGAGGCCACATGGCATGTCCAAGGAGACATGCTTTCTGGGTTCTATATGAATAGAGATGGTTTTAGCCTGCAATTAAAAAAA
AAAAAAAAAACGGTTGAAGCCTTGCTAACTTTTTCCCAGAGCATTCTGGGTTGATATTTCACAGTCAAACGTTTTGGCATGGAAAAAAAA
AAAAGCATTTTAAACTCTTAGTGAATTCAAAGCTCTAAATCCAAACAATGGTGAACACATGTACATAACATTTCATGTTTTCAGAGATAC
GTATGCTTATTTAAGTGCCTTTCATGTTTTAATCAATGTTTGCAGAATTTATCTTAAACCTGAGATGAATTAAAAAATTTTTCTCCTTCA

>7656_7656_1_ATL3-ZDHHC14_ATL3_chr11_63438762_ENST00000398868_ZDHHC14_chr6_158068291_ENST00000359775_length(amino acids)=224AA_BP=20
MKAEAPCCPLSEWQQLPQEEQIKGSWSNKRGKENYNPYSYGNIFTNCCVALCGPISPSLIDRRGYIQPDTPQPAAPSNGITMYGATQSQS
DMCDQDQCIQSTKFVLQAAATPLLQSEPSLTSDELHLPGKPGLGTPCASLTLGPPTPPASMPNLAEATLADVMPRKDEHMGHQFLTPDEA

--------------------------------------------------------------
>7656_7656_2_ATL3-ZDHHC14_ATL3_chr11_63438762_ENST00000398868_ZDHHC14_chr6_158068291_ENST00000414563_length(transcript)=1713nt_BP=323nt
ACACGCGGCAGGCGGTGGCGGGATTCTGCCGCGTGCGCTTTCCCGCCCCGCCTCGCCTAGCCTCGTCCTGCGCTCGCCACGCCTCGGGCT
GTCCGTTGGGCCACGCAGACCGCGCTGCGCTCGCTCCGTCGCGGCTCCGCGTGCCCCACCTTCTGGCTAGTTTTTTCTAGAGCCCAGGCT
CCGCCCGTTTCCCGCTTCCAGGGCCCGGTTCGTTCCCGCCCGCACCCGTCCCTCTCCTCTGCACCCCTGCTGCTTCTGCTTTGAAGGCGG
AGGCTCCATGTTGTCCCCTCAGCGAGTGGCAGCAGCTGCCTCAAGAGGAGCAGATTAAAGGATCCTGGTCAAATAAAAGAGGTAAAGAAA
ATTACAATCCCTACAGCTACGGAAATATCTTTACCAACTGCTGTGTTGCCCTGTGTGGGCCCATCTCACCAAGCCTGATCGACAGAAGAG
GGTACATCCAGCCCGACACGCCGCAGCCAGCAGCACCCTCCAATGGCATCACCATGTACGGGGCCACGCAGTCACAGAGTGACATGGCTG
CAGCCACGCCCCTGCTGCAGAGCGAGCCCAGCCTCACCAGCGACGAGCTGCACCTGCCCGGGAAGCCTGGCCTGGGCACGCCCTGCGCCA
GCCTCACACTGGGCCCGCCCACACCGCCCGCCTCCATGCCCAACCTCGCCGAGGCCACGCTCGCGGACGTGATGCCCCGGAAAGATGAGC
ACATGGGCCACCAGTTCCTGACGCCCGATGAGGCGCCCTCGCCCCCCAGGCTACTGGCGGCGGGCAGCCCCCTGGCGCACAGCCGCACCA
TGCACGTGCTGGGCCTGGCCAGCCAGGACTCCCTGCATGAGGACTCTGTGCGCGGCCTGGTGAAGCTCAGCTCCGTGTGACCCACATGGC
CCCAGGCCGGGGGACACCAGAGGCTCCTCCATGGGCAGCAGGAGTGAGCGGAGGGGTGTGTCCCACAGCGACTTTCCCAGCCAATGCCAC
GGTGGAGATGACAGCCCCAGGTCTGGGGTACAGAGACCACTTAGGATGGCACAGGGTGGCTGGCCCCGGATGCTGAGAGCTTGGTTTCAT
TTGAATTTTCTTCCCCAACCTGAGTGCTTTGACAACAATGGAAATAGAGAAGTGGCTGCTTTCTTTTGGTGACCCTCCAGGGGTGGAATC
GGAGTGTGTCTGCCCGCCCTTGTGACAGACACACGGAAGGCTTCTGACGCTTGTGGCCAGACTGCAATTGCACTTATGTGTTATGCTACT
AATATTTGAAACAGACCTGCCATTCCATTTGTTAATTAAAAAAAAAAAAAATCCTAAAGGGAAAAAACCGACCAGGTGTGGATCTGCATG
CCACGCTGCCGTCTGTGTTACAGTGGTGTTGCTATTTCCAAGGAAGTGCTGCTTTCTTTTTCTTTTTTTAATTTTGTGAATTTTCAAGTG
CTGTTTTGTTGGAAGACAGTGCAACGAACTGAGACTAATGGACAGTGTCATCACTCAGCTTACTGGGCTGAGGCGTCTGTGGAGAGGTGG
CACCGGGGCTGCAGAGGGCGGCTGGGGTTCCGTCGTGTCGGGTGTCACTTCACCTTCTGTTTGGCCGCTCGATGAGGTCTCGTGTTGAGA
TATTGTGTGCCACAACCCCCACAGTCTTCACCTCCGTGTGTGATGAAACTTCCCGTGGACAGCCAATAAAATGACGTCCTCTGTTATTTT

>7656_7656_2_ATL3-ZDHHC14_ATL3_chr11_63438762_ENST00000398868_ZDHHC14_chr6_158068291_ENST00000414563_length(amino acids)=209AA_BP=20
MKAEAPCCPLSEWQQLPQEEQIKGSWSNKRGKENYNPYSYGNIFTNCCVALCGPISPSLIDRRGYIQPDTPQPAAPSNGITMYGATQSQS
DMAAATPLLQSEPSLTSDELHLPGKPGLGTPCASLTLGPPTPPASMPNLAEATLADVMPRKDEHMGHQFLTPDEAPSPPRLLAAGSPLAH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ATL3-ZDHHC14

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ATL3-ZDHHC14

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ATL3-ZDHHC14

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source