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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RPL37A-RPS24 (FusionGDB2 ID:76703)

Fusion Gene Summary for RPL37A-RPS24

check button Fusion gene summary
Fusion gene informationFusion gene name: RPL37A-RPS24
Fusion gene ID: 76703
HgeneTgene
Gene symbol

RPL37A

RPS24

Gene ID

6168

6229

Gene nameribosomal protein L37aribosomal protein S24
SynonymsL37ADBA3|S24|eS24
Cytomap

2q35

10q22.3

Type of geneprotein-codingprotein-coding
Description60S ribosomal protein L37alarge ribosomal subunit protein eL4340S ribosomal protein S24small ribosomal subunit protein eS24
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000446558, ENST00000491306, 
ENST00000600880, ENST00000427280, 
ENST00000441179, ENST00000456586, 
ENST00000598925, 		ENST00000360830, 
ENST00000476545, ENST00000372360, 
ENST00000435275, ENST00000440692, 
Fusion gene scores* DoF score46 X 15 X 6=414016 X 17 X 4=1088
# samples 4617
** MAII scorelog2(46/4140*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1088*10)=-2.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPL37A [Title/Abstract] AND RPS24 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRPL37A(217363601)-RPS24(79796952), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RPL37A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RPS24 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AEC464784RPL37Achr2

217363601

+RPS24chr10

79796952

+


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Fusion Gene ORF analysis for RPL37A-RPS24

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000446558ENST00000360830RPL37Achr2

217363601

+RPS24chr10

79796952

+
5CDS-3UTRENST00000446558ENST00000476545RPL37Achr2

217363601

+RPS24chr10

79796952

+
5CDS-3UTRENST00000491306ENST00000360830RPL37Achr2

217363601

+RPS24chr10

79796952

+
5CDS-3UTRENST00000491306ENST00000476545RPL37Achr2

217363601

+RPS24chr10

79796952

+
5CDS-3UTRENST00000600880ENST00000360830RPL37Achr2

217363601

+RPS24chr10

79796952

+
5CDS-3UTRENST00000600880ENST00000476545RPL37Achr2

217363601

+RPS24chr10

79796952

+
In-frameENST00000446558ENST00000372360RPL37Achr2

217363601

+RPS24chr10

79796952

+
In-frameENST00000446558ENST00000435275RPL37Achr2

217363601

+RPS24chr10

79796952

+
In-frameENST00000446558ENST00000440692RPL37Achr2

217363601

+RPS24chr10

79796952

+
In-frameENST00000491306ENST00000372360RPL37Achr2

217363601

+RPS24chr10

79796952

+
In-frameENST00000491306ENST00000435275RPL37Achr2

217363601

+RPS24chr10

79796952

+
In-frameENST00000491306ENST00000440692RPL37Achr2

217363601

+RPS24chr10

79796952

+
In-frameENST00000600880ENST00000372360RPL37Achr2

217363601

+RPS24chr10

79796952

+
In-frameENST00000600880ENST00000435275RPL37Achr2

217363601

+RPS24chr10

79796952

+
In-frameENST00000600880ENST00000440692RPL37Achr2

217363601

+RPS24chr10

79796952

+
intron-3CDSENST00000427280ENST00000372360RPL37Achr2

217363601

+RPS24chr10

79796952

+
intron-3CDSENST00000427280ENST00000435275RPL37Achr2

217363601

+RPS24chr10

79796952

+
intron-3CDSENST00000427280ENST00000440692RPL37Achr2

217363601

+RPS24chr10

79796952

+
intron-3CDSENST00000441179ENST00000372360RPL37Achr2

217363601

+RPS24chr10

79796952

+
intron-3CDSENST00000441179ENST00000435275RPL37Achr2

217363601

+RPS24chr10

79796952

+
intron-3CDSENST00000441179ENST00000440692RPL37Achr2

217363601

+RPS24chr10

79796952

+
intron-3CDSENST00000456586ENST00000372360RPL37Achr2

217363601

+RPS24chr10

79796952

+
intron-3CDSENST00000456586ENST00000435275RPL37Achr2

217363601

+RPS24chr10

79796952

+
intron-3CDSENST00000456586ENST00000440692RPL37Achr2

217363601

+RPS24chr10

79796952

+
intron-3CDSENST00000598925ENST00000372360RPL37Achr2

217363601

+RPS24chr10

79796952

+
intron-3CDSENST00000598925ENST00000435275RPL37Achr2

217363601

+RPS24chr10

79796952

+
intron-3CDSENST00000598925ENST00000440692RPL37Achr2

217363601

+RPS24chr10

79796952

+
intron-3UTRENST00000427280ENST00000360830RPL37Achr2

217363601

+RPS24chr10

79796952

+
intron-3UTRENST00000427280ENST00000476545RPL37Achr2

217363601

+RPS24chr10

79796952

+
intron-3UTRENST00000441179ENST00000360830RPL37Achr2

217363601

+RPS24chr10

79796952

+
intron-3UTRENST00000441179ENST00000476545RPL37Achr2

217363601

+RPS24chr10

79796952

+
intron-3UTRENST00000456586ENST00000360830RPL37Achr2

217363601

+RPS24chr10

79796952

+
intron-3UTRENST00000456586ENST00000476545RPL37Achr2

217363601

+RPS24chr10

79796952

+
intron-3UTRENST00000598925ENST00000360830RPL37Achr2

217363601

+RPS24chr10

79796952

+
intron-3UTRENST00000598925ENST00000476545RPL37Achr2

217363601

+RPS24chr10

79796952

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000491306RPL37Achr2217363601+ENST00000435275RPS24chr1079796952+924689583206125
ENST00000491306RPL37Achr2217363601+ENST00000440692RPS24chr1079796952+30826891236580218
ENST00000491306RPL37Achr2217363601+ENST00000372360RPS24chr1079796952+883689583206125
ENST00000600880RPL37Achr2217363601+ENST00000435275RPS24chr1079796952+263281865543
ENST00000600880RPL37Achr2217363601+ENST00000440692RPS24chr1079796952+24212825618197
ENST00000600880RPL37Achr2217363601+ENST00000372360RPS24chr1079796952+222282515041
ENST00000446558RPL37Achr2217363601+ENST00000435275RPS24chr1079796952+258231815043
ENST00000446558RPL37Achr2217363601+ENST00000440692RPS24chr1079796952+24162320613197
ENST00000446558RPL37Achr2217363601+ENST00000372360RPS24chr1079796952+217232014541

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000491306ENST00000435275RPL37Achr2217363601+RPS24chr1079796952+0.451199740.5488003
ENST00000491306ENST00000440692RPL37Achr2217363601+RPS24chr1079796952+0.258589180.7414108
ENST00000491306ENST00000372360RPL37Achr2217363601+RPS24chr1079796952+0.373954450.6260455
ENST00000600880ENST00000435275RPL37Achr2217363601+RPS24chr1079796952+0.506744440.4932556
ENST00000600880ENST00000440692RPL37Achr2217363601+RPS24chr1079796952+0.303904440.6960955
ENST00000600880ENST00000372360RPL37Achr2217363601+RPS24chr1079796952+0.451795040.54820496
ENST00000446558ENST00000435275RPL37Achr2217363601+RPS24chr1079796952+0.535632550.46436748
ENST00000446558ENST00000440692RPL37Achr2217363601+RPS24chr1079796952+0.229320240.7706798
ENST00000446558ENST00000372360RPL37Achr2217363601+RPS24chr1079796952+0.442223970.55777603

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Fusion Genomic Features for RPL37A-RPS24


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RPL37Achr2217363600+RPS24chr1079796951+7.93E-060.99999213
RPL37Achr2217363600+RPS24chr1079796951+7.93E-060.99999213

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RPL37A-RPS24


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:217363601/chr10:79796952)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRPL37Achr2:217363601chr10:79796952ENST00000491306+1439_60193.0Zinc fingerNote=C4-type


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Fusion Gene Sequence for RPL37A-RPS24


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>76703_76703_1_RPL37A-RPS24_RPL37A_chr2_217363601_ENST00000446558_RPS24_chr10_79796952_ENST00000372360_length(transcript)=217nt_BP=23nt
CGGACCTAGGTCGCGGCGACATGCATGGCCTGTATGAGAAGAAAAAGACCTCAAGAAAGCAACGAAAGGAACGCAAGAACAGAATGAAGA
AAGTCAGGGGGACTGCAAAGGCCAATGTTGGTGCTGGCAAAAAGCCGAAGGAGTAAAGGTGCTGCAATGATGTTAGCTGTGGCCACTGTG

>76703_76703_1_RPL37A-RPS24_RPL37A_chr2_217363601_ENST00000446558_RPS24_chr10_79796952_ENST00000372360_length(amino acids)=41AA_BP=1

--------------------------------------------------------------
>76703_76703_2_RPL37A-RPS24_RPL37A_chr2_217363601_ENST00000446558_RPS24_chr10_79796952_ENST00000435275_length(transcript)=258nt_BP=23nt
CGGACCTAGGTCGCGGCGACATGCATGGCCTGTATGAGAAGAAAAAGACCTCAAGAAAGCAACGAAAGGAACGCAAGAACAGAATGAAGA
AAGTCAGGGGGACTGCAAAGGCCAATGTTGGTGCTGGCAAAAAGCAGTGAGCTGGAGATTGGATCACAGCCGAAGGAGTAAAGGTGCTGC

>76703_76703_2_RPL37A-RPS24_RPL37A_chr2_217363601_ENST00000446558_RPS24_chr10_79796952_ENST00000435275_length(amino acids)=43AA_BP=

--------------------------------------------------------------
>76703_76703_3_RPL37A-RPS24_RPL37A_chr2_217363601_ENST00000446558_RPS24_chr10_79796952_ENST00000440692_length(transcript)=2416nt_BP=23nt
CGGACCTAGGTCGCGGCGACATGCATGGCCTGTATGAGAAGAAAAAGACCTCAAGAAAGCAACGAAAGGAACGCAAGAACAGAATGAAGA
AAGTCAGGGGGACTGCAAAGGCCAATGTTGGTGCTGGCAAAAAGATGAGGGAATTGGGGCTTGGAGTGCAAGCATTGGGAAGAATTTCCC
AGGAAGAGAGATGCACAGATGTGAAGAACTCGAAGGCAAGAGAAAGCCGGGGGGTTGTGTGGCAGGTAGAAGTGCCAGGACCGTGGAGCG
TGTGGACATGTGGCAGATTGCGGAGGGGCTGTGGCAAGTATTTACAGGTGGCCGTTACCTGGAGGAAGACTGAAAACAGAGAACAGTGCT
GCCAGGCGTGCCTTTTGGAGAGGGCACTGGTCAGAAACGGAGCCTTCATGTCGCCTGCCTCACCTGCTCCTGCTGGTTCTCCCCACCCTG
TGGACGGTGACTTGGTCCTCCACTTGCCAGAAGCCTTGTCAGCAACCTTGACTCTGTCACCCCACATCCAGGCCATCAACAAGTCTTTTG
GCCCTTTCTTTGAAATCCACCAGGAATCCAGCTGCTTCTCCCCACCTTCCTGCCTCTCTGGTCTGGGCCACTAATGTCACTGCCATGGCC
GCCTTGCTGCATTTCTGAGGATGCTTCATCTCTCCACCTTCTTCTCCACTCAGCAGCCAGCAGGGCACTGTGGAAATCGGAGTCACATGA
GCTGGCACCTCTGTTCAGAACCCTCCAGGGCTCCACATCTCTCTCACCCAAATGCCAAAGACCTCCCCACGCCCCCACAATCCCCCACGA
CCTGGCCACTGGCCTCCCACCACCTTCCAGCTCCAGCGGCTCCTACCACATTTAAGGCTTTCCTTCCTAGTTTTAATTTTTCCTCGTCAG
CAGTTGATTTTATTATTTTCTTGTTTATTGGTATTTTCCCACTAGAAATGAAGCTGCGTGAAGTTAGAGATTTTTTTTTTTGGTCTGTGT
TCCTAATTAGCTCATTGCTATACCCCTGGCGCCCAGAACAATGCCTTGGACACAGTACGCAGTAGACTAAATAAATACTTGTTGAATGAC
TGACTGACGGAATGACGGCTGTGTGGGGAGTGGATTGGGTCGTGAGGCAGAGGCTGCGGTGGAAACTCAGGCAGGAGGTGATGGTGGTTC
TTGGGGCTGCGGAATGCCAAGTTTAGAAGCTCTTCCTCTGCTGTGGCACATGAACCGGTCACTCGAGAAGGCTTTTAGATTTACTTTGCC
TAATCCCCTCTTAGTGCATGTGGGGAAACTGAGGTACACAAAAGGAATTCCCCACCAAGTTAGGGGCAGAACCTAGCCCCCTTGTCTCCC
AGATGGATATCTTCTTTTTTTTTTGAGACGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTACCATCTTGGCTCACTGCAACCT
CTGCTTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTGTCTGCGATTACAGGTGCACACAACCACGCCTGGCTAATTTTTGT
ATTTTTAGTAGAGACGGGGTTTCACCGTGTTGGTCAGGGTGACCTCAAACTCCTGACCTCATGATCCACCCAGCTCAGCCTCCCAACGTG
CTGGGATTACAGGCATGAGCCACCGTGCCTGGCTGGACATCTTGTTATTAAAGCTTCTTCTCTCTTTGTAGGGGAGGGGGAGATGCCTCT
GGTGGAGAAGACCAGTGTGGCAGTGACTGTGTCTGTTAGTGAACCTGGTGGCTGGTTGAGGGTCTGTCGTGGTGACTGAGGACACATACA
AAGTGCTTTTCTCAGTGGTCACCTTGGTGTTGGTGAATAAGGGTCAGAAGATGGCTCCTGTCCTAGGGCACTGCCAGTCGGTTTGGAAGC
TGAAATGCCTGCTTAGCAGTTTGAGGAAACACAGACCTTGGAGGATCTTCTGGTTGCCTCTTCAAGAATTCATTCTATTCCCCTTCTGCT
CCCCAAATTTGCTTTTCTTGGGGTGGGTCTTGGTTGGCCTAAGCCAAGAAAGTATGGCATCTACTCCTTCCATAGCAATAGCTCAGGAAT
AGGCAGTGACCCAGACCTGAACCAATCAGTGCATGGAATTACCCCTGGCCAAAGTGGTTGATTGAGGCTGGGTGCAAGCAGAGTTGTGAG
AAGGCTCCCATTTGGTGGTTGGAGAGATCGCACTTGCTCCAGAGGTCATAATGTGCAGATCTGAGGCTTGGAACTGCTGCAGACATTTTG
CTACCACAAGTGAAGCCACCCTGACGACACAGTTGACAATTTGGAGCAGGGCAGAGCTGAGAGAACAGCAGGGAAACAGCCAGAGTCTTG

>76703_76703_3_RPL37A-RPS24_RPL37A_chr2_217363601_ENST00000446558_RPS24_chr10_79796952_ENST00000440692_length(amino acids)=197AA_BP=1
MHGLYEKKKTSRKQRKERKNRMKKVRGTAKANVGAGKKMRELGLGVQALGRISQEERCTDVKNSKARESRGVVWQVEVPGPWSVWTCGRL
RRGCGKYLQVAVTWRKTENREQCCQACLLERALVRNGAFMSPASPAPAGSPHPVDGDLVLHLPEALSATLTLSPHIQAINKSFGPFFEIH

--------------------------------------------------------------
>76703_76703_4_RPL37A-RPS24_RPL37A_chr2_217363601_ENST00000491306_RPS24_chr10_79796952_ENST00000372360_length(transcript)=883nt_BP=689nt
GACTTTCCTCAGGAAACACCAGGCTCTTCTGAATTAGTCGCGAGCAGAACCATCGTCCTTTCCTTCAGAACTCTGACCAGTTTGAAACTG
TCTAACTTCTTAATGTGGCTATATGATCGTTTGCAGCTGGCCTGCAACTTGTTCTGGGAATGGAACCTTGGATTTTAGTCACCACTGTCG
CTAGCATCCTGCACAGTCAGCCACTTTTAGAGAGCATAATGCAGAGGGGGAAATAAATGAGATTTGGAATAGAGACGGGGTTTCACCCTG
CTGGCCAGGCTGGTCTCGAACTCCTGACCCACCCCGCCTCCCAAAGTGTTAGAATCACAAGCGTGAGCCACCGCGCCCGGCCCCACAAAT
GTAAGATTTATGCACTTCTCCAAGCCAAGTGCTGTGCATCGAATGGAGGAACTCGTACCTTTGCAGGATTTTGTGATATATGTGAAATAA
TCCGGACATGCTTCTGCTATGGTTGTTTGTCGCCATAGTTTGCGAATCTGGGTAAACCTGGATGAGAGAGACGCCTTACAATTGCAAACA
TTTCTCAGGAGGCCGCCTGAAAACGCCCAAACCATAGAGCTCAGTTCCTAGCTAGGCCTCTACCAGCCACTTCCGCTCGTCCGCCTAATA
CCGCGCCTGCGCACCGCGTCTCTTCCTTTCTGGGCTCGGACCTAGGTCGCGGCGACATGCATGGCCTGTATGAGAAGAAAAAGACCTCAA
GAAAGCAACGAAAGGAACGCAAGAACAGAATGAAGAAAGTCAGGGGGACTGCAAAGGCCAATGTTGGTGCTGGCAAAAAGCCGAAGGAGT

>76703_76703_4_RPL37A-RPS24_RPL37A_chr2_217363601_ENST00000491306_RPS24_chr10_79796952_ENST00000372360_length(amino acids)=125AA_BP=
MSSMVWAFSGGLLRNVCNCKASLSSRFTQIRKLWRQTTIAEACPDYFTYITKSCKGTSSSIRCTALGLEKCINLTFVGPGAVAHACDSNT

--------------------------------------------------------------
>76703_76703_5_RPL37A-RPS24_RPL37A_chr2_217363601_ENST00000491306_RPS24_chr10_79796952_ENST00000435275_length(transcript)=924nt_BP=689nt
GACTTTCCTCAGGAAACACCAGGCTCTTCTGAATTAGTCGCGAGCAGAACCATCGTCCTTTCCTTCAGAACTCTGACCAGTTTGAAACTG
TCTAACTTCTTAATGTGGCTATATGATCGTTTGCAGCTGGCCTGCAACTTGTTCTGGGAATGGAACCTTGGATTTTAGTCACCACTGTCG
CTAGCATCCTGCACAGTCAGCCACTTTTAGAGAGCATAATGCAGAGGGGGAAATAAATGAGATTTGGAATAGAGACGGGGTTTCACCCTG
CTGGCCAGGCTGGTCTCGAACTCCTGACCCACCCCGCCTCCCAAAGTGTTAGAATCACAAGCGTGAGCCACCGCGCCCGGCCCCACAAAT
GTAAGATTTATGCACTTCTCCAAGCCAAGTGCTGTGCATCGAATGGAGGAACTCGTACCTTTGCAGGATTTTGTGATATATGTGAAATAA
TCCGGACATGCTTCTGCTATGGTTGTTTGTCGCCATAGTTTGCGAATCTGGGTAAACCTGGATGAGAGAGACGCCTTACAATTGCAAACA
TTTCTCAGGAGGCCGCCTGAAAACGCCCAAACCATAGAGCTCAGTTCCTAGCTAGGCCTCTACCAGCCACTTCCGCTCGTCCGCCTAATA
CCGCGCCTGCGCACCGCGTCTCTTCCTTTCTGGGCTCGGACCTAGGTCGCGGCGACATGCATGGCCTGTATGAGAAGAAAAAGACCTCAA
GAAAGCAACGAAAGGAACGCAAGAACAGAATGAAGAAAGTCAGGGGGACTGCAAAGGCCAATGTTGGTGCTGGCAAAAAGCAGTGAGCTG
GAGATTGGATCACAGCCGAAGGAGTAAAGGTGCTGCAATGATGTTAGCTGTGGCCACTGTGGATTTTTCGCAAGAACATTAATAAACTAA

>76703_76703_5_RPL37A-RPS24_RPL37A_chr2_217363601_ENST00000491306_RPS24_chr10_79796952_ENST00000435275_length(amino acids)=125AA_BP=
MSSMVWAFSGGLLRNVCNCKASLSSRFTQIRKLWRQTTIAEACPDYFTYITKSCKGTSSSIRCTALGLEKCINLTFVGPGAVAHACDSNT

--------------------------------------------------------------
>76703_76703_6_RPL37A-RPS24_RPL37A_chr2_217363601_ENST00000491306_RPS24_chr10_79796952_ENST00000440692_length(transcript)=3082nt_BP=689nt
GACTTTCCTCAGGAAACACCAGGCTCTTCTGAATTAGTCGCGAGCAGAACCATCGTCCTTTCCTTCAGAACTCTGACCAGTTTGAAACTG
TCTAACTTCTTAATGTGGCTATATGATCGTTTGCAGCTGGCCTGCAACTTGTTCTGGGAATGGAACCTTGGATTTTAGTCACCACTGTCG
CTAGCATCCTGCACAGTCAGCCACTTTTAGAGAGCATAATGCAGAGGGGGAAATAAATGAGATTTGGAATAGAGACGGGGTTTCACCCTG
CTGGCCAGGCTGGTCTCGAACTCCTGACCCACCCCGCCTCCCAAAGTGTTAGAATCACAAGCGTGAGCCACCGCGCCCGGCCCCACAAAT
GTAAGATTTATGCACTTCTCCAAGCCAAGTGCTGTGCATCGAATGGAGGAACTCGTACCTTTGCAGGATTTTGTGATATATGTGAAATAA
TCCGGACATGCTTCTGCTATGGTTGTTTGTCGCCATAGTTTGCGAATCTGGGTAAACCTGGATGAGAGAGACGCCTTACAATTGCAAACA
TTTCTCAGGAGGCCGCCTGAAAACGCCCAAACCATAGAGCTCAGTTCCTAGCTAGGCCTCTACCAGCCACTTCCGCTCGTCCGCCTAATA
CCGCGCCTGCGCACCGCGTCTCTTCCTTTCTGGGCTCGGACCTAGGTCGCGGCGACATGCATGGCCTGTATGAGAAGAAAAAGACCTCAA
GAAAGCAACGAAAGGAACGCAAGAACAGAATGAAGAAAGTCAGGGGGACTGCAAAGGCCAATGTTGGTGCTGGCAAAAAGATGAGGGAAT
TGGGGCTTGGAGTGCAAGCATTGGGAAGAATTTCCCAGGAAGAGAGATGCACAGATGTGAAGAACTCGAAGGCAAGAGAAAGCCGGGGGG
TTGTGTGGCAGGTAGAAGTGCCAGGACCGTGGAGCGTGTGGACATGTGGCAGATTGCGGAGGGGCTGTGGCAAGTATTTACAGGTGGCCG
TTACCTGGAGGAAGACTGAAAACAGAGAACAGTGCTGCCAGGCGTGCCTTTTGGAGAGGGCACTGGTCAGAAACGGAGCCTTCATGTCGC
CTGCCTCACCTGCTCCTGCTGGTTCTCCCCACCCTGTGGACGGTGACTTGGTCCTCCACTTGCCAGAAGCCTTGTCAGCAACCTTGACTC
TGTCACCCCACATCCAGGCCATCAACAAGTCTTTTGGCCCTTTCTTTGAAATCCACCAGGAATCCAGCTGCTTCTCCCCACCTTCCTGCC
TCTCTGGTCTGGGCCACTAATGTCACTGCCATGGCCGCCTTGCTGCATTTCTGAGGATGCTTCATCTCTCCACCTTCTTCTCCACTCAGC
AGCCAGCAGGGCACTGTGGAAATCGGAGTCACATGAGCTGGCACCTCTGTTCAGAACCCTCCAGGGCTCCACATCTCTCTCACCCAAATG
CCAAAGACCTCCCCACGCCCCCACAATCCCCCACGACCTGGCCACTGGCCTCCCACCACCTTCCAGCTCCAGCGGCTCCTACCACATTTA
AGGCTTTCCTTCCTAGTTTTAATTTTTCCTCGTCAGCAGTTGATTTTATTATTTTCTTGTTTATTGGTATTTTCCCACTAGAAATGAAGC
TGCGTGAAGTTAGAGATTTTTTTTTTTGGTCTGTGTTCCTAATTAGCTCATTGCTATACCCCTGGCGCCCAGAACAATGCCTTGGACACA
GTACGCAGTAGACTAAATAAATACTTGTTGAATGACTGACTGACGGAATGACGGCTGTGTGGGGAGTGGATTGGGTCGTGAGGCAGAGGC
TGCGGTGGAAACTCAGGCAGGAGGTGATGGTGGTTCTTGGGGCTGCGGAATGCCAAGTTTAGAAGCTCTTCCTCTGCTGTGGCACATGAA
CCGGTCACTCGAGAAGGCTTTTAGATTTACTTTGCCTAATCCCCTCTTAGTGCATGTGGGGAAACTGAGGTACACAAAAGGAATTCCCCA
CCAAGTTAGGGGCAGAACCTAGCCCCCTTGTCTCCCAGATGGATATCTTCTTTTTTTTTTGAGACGGAGTCTTGCTCTGTTGCCCAGGCT
GGAGTGCAGTGGTACCATCTTGGCTCACTGCAACCTCTGCTTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTGTCTGCGAT
TACAGGTGCACACAACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTGGTCAGGGTGACCTCAAACTCCT
GACCTCATGATCCACCCAGCTCAGCCTCCCAACGTGCTGGGATTACAGGCATGAGCCACCGTGCCTGGCTGGACATCTTGTTATTAAAGC
TTCTTCTCTCTTTGTAGGGGAGGGGGAGATGCCTCTGGTGGAGAAGACCAGTGTGGCAGTGACTGTGTCTGTTAGTGAACCTGGTGGCTG
GTTGAGGGTCTGTCGTGGTGACTGAGGACACATACAAAGTGCTTTTCTCAGTGGTCACCTTGGTGTTGGTGAATAAGGGTCAGAAGATGG
CTCCTGTCCTAGGGCACTGCCAGTCGGTTTGGAAGCTGAAATGCCTGCTTAGCAGTTTGAGGAAACACAGACCTTGGAGGATCTTCTGGT
TGCCTCTTCAAGAATTCATTCTATTCCCCTTCTGCTCCCCAAATTTGCTTTTCTTGGGGTGGGTCTTGGTTGGCCTAAGCCAAGAAAGTA
TGGCATCTACTCCTTCCATAGCAATAGCTCAGGAATAGGCAGTGACCCAGACCTGAACCAATCAGTGCATGGAATTACCCCTGGCCAAAG
TGGTTGATTGAGGCTGGGTGCAAGCAGAGTTGTGAGAAGGCTCCCATTTGGTGGTTGGAGAGATCGCACTTGCTCCAGAGGTCATAATGT
GCAGATCTGAGGCTTGGAACTGCTGCAGACATTTTGCTACCACAAGTGAAGCCACCCTGACGACACAGTTGACAATTTGGAGCAGGGCAG
AGCTGAGAGAACAGCAGGGAAACAGCCAGAGTCTTGCTCAAGCCTCCCTGAAGTATCTATACCCCTGGACTCTAGTTATGGGGGCTAATA

>76703_76703_6_RPL37A-RPS24_RPL37A_chr2_217363601_ENST00000491306_RPS24_chr10_79796952_ENST00000440692_length(amino acids)=218AA_BP=1
MDSWWISKKGPKDLLMAWMWGDRVKVADKASGKWRTKSPSTGWGEPAGAGEAGDMKAPFLTSALSKRHAWQHCSLFSVFLQVTATCKYLP
QPLRNLPHVHTLHGPGTSTCHTTPRLSLAFEFFTSVHLSSWEILPNACTPSPNSLIFLPAPTLAFAVPLTFFILFLRSFRCFLEVFFFSY

--------------------------------------------------------------
>76703_76703_7_RPL37A-RPS24_RPL37A_chr2_217363601_ENST00000600880_RPS24_chr10_79796952_ENST00000372360_length(transcript)=222nt_BP=28nt
GGGCTCGGACCTAGGTCGCGGCGACATGCATGGCCTGTATGAGAAGAAAAAGACCTCAAGAAAGCAACGAAAGGAACGCAAGAACAGAAT
GAAGAAAGTCAGGGGGACTGCAAAGGCCAATGTTGGTGCTGGCAAAAAGCCGAAGGAGTAAAGGTGCTGCAATGATGTTAGCTGTGGCCA

>76703_76703_7_RPL37A-RPS24_RPL37A_chr2_217363601_ENST00000600880_RPS24_chr10_79796952_ENST00000372360_length(amino acids)=41AA_BP=1

--------------------------------------------------------------
>76703_76703_8_RPL37A-RPS24_RPL37A_chr2_217363601_ENST00000600880_RPS24_chr10_79796952_ENST00000435275_length(transcript)=263nt_BP=28nt
GGGCTCGGACCTAGGTCGCGGCGACATGCATGGCCTGTATGAGAAGAAAAAGACCTCAAGAAAGCAACGAAAGGAACGCAAGAACAGAAT
GAAGAAAGTCAGGGGGACTGCAAAGGCCAATGTTGGTGCTGGCAAAAAGCAGTGAGCTGGAGATTGGATCACAGCCGAAGGAGTAAAGGT

>76703_76703_8_RPL37A-RPS24_RPL37A_chr2_217363601_ENST00000600880_RPS24_chr10_79796952_ENST00000435275_length(amino acids)=43AA_BP=

--------------------------------------------------------------
>76703_76703_9_RPL37A-RPS24_RPL37A_chr2_217363601_ENST00000600880_RPS24_chr10_79796952_ENST00000440692_length(transcript)=2421nt_BP=28nt
GGGCTCGGACCTAGGTCGCGGCGACATGCATGGCCTGTATGAGAAGAAAAAGACCTCAAGAAAGCAACGAAAGGAACGCAAGAACAGAAT
GAAGAAAGTCAGGGGGACTGCAAAGGCCAATGTTGGTGCTGGCAAAAAGATGAGGGAATTGGGGCTTGGAGTGCAAGCATTGGGAAGAAT
TTCCCAGGAAGAGAGATGCACAGATGTGAAGAACTCGAAGGCAAGAGAAAGCCGGGGGGTTGTGTGGCAGGTAGAAGTGCCAGGACCGTG
GAGCGTGTGGACATGTGGCAGATTGCGGAGGGGCTGTGGCAAGTATTTACAGGTGGCCGTTACCTGGAGGAAGACTGAAAACAGAGAACA
GTGCTGCCAGGCGTGCCTTTTGGAGAGGGCACTGGTCAGAAACGGAGCCTTCATGTCGCCTGCCTCACCTGCTCCTGCTGGTTCTCCCCA
CCCTGTGGACGGTGACTTGGTCCTCCACTTGCCAGAAGCCTTGTCAGCAACCTTGACTCTGTCACCCCACATCCAGGCCATCAACAAGTC
TTTTGGCCCTTTCTTTGAAATCCACCAGGAATCCAGCTGCTTCTCCCCACCTTCCTGCCTCTCTGGTCTGGGCCACTAATGTCACTGCCA
TGGCCGCCTTGCTGCATTTCTGAGGATGCTTCATCTCTCCACCTTCTTCTCCACTCAGCAGCCAGCAGGGCACTGTGGAAATCGGAGTCA
CATGAGCTGGCACCTCTGTTCAGAACCCTCCAGGGCTCCACATCTCTCTCACCCAAATGCCAAAGACCTCCCCACGCCCCCACAATCCCC
CACGACCTGGCCACTGGCCTCCCACCACCTTCCAGCTCCAGCGGCTCCTACCACATTTAAGGCTTTCCTTCCTAGTTTTAATTTTTCCTC
GTCAGCAGTTGATTTTATTATTTTCTTGTTTATTGGTATTTTCCCACTAGAAATGAAGCTGCGTGAAGTTAGAGATTTTTTTTTTTGGTC
TGTGTTCCTAATTAGCTCATTGCTATACCCCTGGCGCCCAGAACAATGCCTTGGACACAGTACGCAGTAGACTAAATAAATACTTGTTGA
ATGACTGACTGACGGAATGACGGCTGTGTGGGGAGTGGATTGGGTCGTGAGGCAGAGGCTGCGGTGGAAACTCAGGCAGGAGGTGATGGT
GGTTCTTGGGGCTGCGGAATGCCAAGTTTAGAAGCTCTTCCTCTGCTGTGGCACATGAACCGGTCACTCGAGAAGGCTTTTAGATTTACT
TTGCCTAATCCCCTCTTAGTGCATGTGGGGAAACTGAGGTACACAAAAGGAATTCCCCACCAAGTTAGGGGCAGAACCTAGCCCCCTTGT
CTCCCAGATGGATATCTTCTTTTTTTTTTGAGACGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTACCATCTTGGCTCACTGC
AACCTCTGCTTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTGTCTGCGATTACAGGTGCACACAACCACGCCTGGCTAATT
TTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTGGTCAGGGTGACCTCAAACTCCTGACCTCATGATCCACCCAGCTCAGCCTCCCA
ACGTGCTGGGATTACAGGCATGAGCCACCGTGCCTGGCTGGACATCTTGTTATTAAAGCTTCTTCTCTCTTTGTAGGGGAGGGGGAGATG
CCTCTGGTGGAGAAGACCAGTGTGGCAGTGACTGTGTCTGTTAGTGAACCTGGTGGCTGGTTGAGGGTCTGTCGTGGTGACTGAGGACAC
ATACAAAGTGCTTTTCTCAGTGGTCACCTTGGTGTTGGTGAATAAGGGTCAGAAGATGGCTCCTGTCCTAGGGCACTGCCAGTCGGTTTG
GAAGCTGAAATGCCTGCTTAGCAGTTTGAGGAAACACAGACCTTGGAGGATCTTCTGGTTGCCTCTTCAAGAATTCATTCTATTCCCCTT
CTGCTCCCCAAATTTGCTTTTCTTGGGGTGGGTCTTGGTTGGCCTAAGCCAAGAAAGTATGGCATCTACTCCTTCCATAGCAATAGCTCA
GGAATAGGCAGTGACCCAGACCTGAACCAATCAGTGCATGGAATTACCCCTGGCCAAAGTGGTTGATTGAGGCTGGGTGCAAGCAGAGTT
GTGAGAAGGCTCCCATTTGGTGGTTGGAGAGATCGCACTTGCTCCAGAGGTCATAATGTGCAGATCTGAGGCTTGGAACTGCTGCAGACA
TTTTGCTACCACAAGTGAAGCCACCCTGACGACACAGTTGACAATTTGGAGCAGGGCAGAGCTGAGAGAACAGCAGGGAAACAGCCAGAG

>76703_76703_9_RPL37A-RPS24_RPL37A_chr2_217363601_ENST00000600880_RPS24_chr10_79796952_ENST00000440692_length(amino acids)=197AA_BP=1
MHGLYEKKKTSRKQRKERKNRMKKVRGTAKANVGAGKKMRELGLGVQALGRISQEERCTDVKNSKARESRGVVWQVEVPGPWSVWTCGRL
RRGCGKYLQVAVTWRKTENREQCCQACLLERALVRNGAFMSPASPAPAGSPHPVDGDLVLHLPEALSATLTLSPHIQAINKSFGPFFEIH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RPL37A-RPS24


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RPL37A-RPS24


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RPL37A-RPS24


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource