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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:AAMP-ANKZF1 (FusionGDB2 ID:77)

Fusion Gene Summary for AAMP-ANKZF1

Fusion gene summary

Fusion gene information	Fusion gene name: AAMP-ANKZF1
	Fusion gene ID: 77
		Hgene	Tgene
	Gene symbol	AAMP	ANKZF1
	Gene ID	14	55139
	Gene name	angio associated migratory cell protein	ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1
	Synonyms	-	Vms1\|ZNF744
	Cytomap	2q35	2q35
	Type of gene	protein-coding	protein-coding
	Description	angio-associated migratory cell protein	ankyrin repeat and zinc finger domain-containing protein 1ankyrin repeat and zinc finger domain containing 1zinc finger protein 744
	Modification date	20200320	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000248450, ENST00000420660, ENST00000444053,	ENST00000409849, ENST00000410034, ENST00000323348,
Fusion gene scores	* DoF score	2 X 1 X 2=4	4 X 4 X 3=48
	# samples	2	4
	** MAII score	log2(2/4*10)=2.32192809488736	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: AAMP [Title/Abstract] AND ANKZF1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	AAMP(219134105)-ANKZF1(220096650), # samples:1
Anticipated loss of major functional domain due to fusion event.	AAMP-ANKZF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. AAMP-ANKZF1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. AAMP-ANKZF1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across AAMP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ANKZF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-HU-A4GN-01A	AAMP	chr2	219134105	-	ANKZF1	chr2	220096650	+

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Fusion Gene ORF analysis for AAMP-ANKZF1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000248450	ENST00000409849	AAMP	chr2	219134105	-	ANKZF1	chr2	220096650	+
5CDS-intron	ENST00000248450	ENST00000410034	AAMP	chr2	219134105	-	ANKZF1	chr2	220096650	+
5CDS-intron	ENST00000420660	ENST00000409849	AAMP	chr2	219134105	-	ANKZF1	chr2	220096650	+
5CDS-intron	ENST00000420660	ENST00000410034	AAMP	chr2	219134105	-	ANKZF1	chr2	220096650	+
5CDS-intron	ENST00000444053	ENST00000409849	AAMP	chr2	219134105	-	ANKZF1	chr2	220096650	+
5CDS-intron	ENST00000444053	ENST00000410034	AAMP	chr2	219134105	-	ANKZF1	chr2	220096650	+
Frame-shift	ENST00000420660	ENST00000323348	AAMP	chr2	219134105	-	ANKZF1	chr2	220096650	+
In-frame	ENST00000248450	ENST00000323348	AAMP	chr2	219134105	-	ANKZF1	chr2	220096650	+
In-frame	ENST00000444053	ENST00000323348	AAMP	chr2	219134105	-	ANKZF1	chr2	220096650	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000248450

AAMP

chr2

219134105

ENST00000323348

ANKZF1

chr2

220096650

2702

445

2477

817

ENST00000444053

AAMP

chr2

219134105

ENST00000323348

ANKZF1

chr2

220096650

2626

369

2401

781

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000248450	ENST00000323348	AAMP	chr2	219134105	-	ANKZF1	chr2	220096650	+	0.00782648	0.99217355
ENST00000444053	ENST00000323348	AAMP	chr2	219134105	-	ANKZF1	chr2	220096650	+	0.013021704	0.9869783

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Fusion Genomic Features for AAMP-ANKZF1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
AAMP	chr2	219134104	-	ANKZF1	chr2	220096649	+	7.63E-06	0.9999924
AAMP	chr2	219134104	-	ANKZF1	chr2	220096649	+	7.63E-06	0.9999924

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AAMP-ANKZF1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:219134105/chr2:220096650)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

AAMP

chr2:219134105

chr2:220096650

ENST00000248450

53_59

435.0

Compositional bias

Note=Poly-Glu

Tgene

ANKZF1

chr2:219134105

chr2:220096650

ENST00000323348

609_659

727.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ANKZF1

chr2:219134105

chr2:220096650

ENST00000410034

609_659

727.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ANKZF1

chr2:219134105

chr2:220096650

ENST00000323348

654_666

727.0

Region

VCP/p97-interacting motif (VIM)

Tgene

ANKZF1

chr2:219134105

chr2:220096650

ENST00000410034

654_666

727.0

Region

VCP/p97-interacting motif (VIM)

Tgene

ANKZF1

chr2:219134105

chr2:220096650

ENST00000323348

493_526

727.0

Repeat

Note=ANK 1

Tgene

ANKZF1

chr2:219134105

chr2:220096650

ENST00000323348

534_563

727.0

Repeat

Note=ANK 2

Tgene

ANKZF1

chr2:219134105

chr2:220096650

ENST00000410034

493_526

727.0

Repeat

Note=ANK 1

Tgene

ANKZF1

chr2:219134105

chr2:220096650

ENST00000410034

534_563

727.0

Repeat

Note=ANK 2

Tgene

ANKZF1

chr2:219134105

chr2:220096650

ENST00000323348

72_96

727.0

Zinc finger

Note=C2H2-type

Tgene

ANKZF1

chr2:219134105

chr2:220096650

ENST00000410034

72_96

727.0

Zinc finger

Note=C2H2-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

AAMP

chr2:219134105

chr2:220096650

ENST00000248450

132_171

435.0

Repeat

Note=WD 2

Hgene

AAMP

chr2:219134105

chr2:220096650

ENST00000248450

173_212

435.0

Repeat

Note=WD 3

Hgene

AAMP

chr2:219134105

chr2:220096650

ENST00000248450

214_254

435.0

Repeat

Note=WD 4

Hgene

AAMP

chr2:219134105

chr2:220096650

ENST00000248450

258_299

435.0

Repeat

Note=WD 5

Hgene

AAMP

chr2:219134105

chr2:220096650

ENST00000248450

315_354

435.0

Repeat

Note=WD 6

Hgene

AAMP

chr2:219134105

chr2:220096650

ENST00000248450

356_395

435.0

Repeat

Note=WD 7

Hgene

AAMP

chr2:219134105

chr2:220096650

ENST00000248450

398_433

435.0

Repeat

Note=WD 8

Hgene

AAMP

chr2:219134105

chr2:220096650

ENST00000248450

89_129

435.0

Repeat

Note=WD 1

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Fusion Gene Sequence for AAMP-ANKZF1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>77_77_1_AAMP-ANKZF1_AAMP_chr2_219134105_ENST00000248450_ANKZF1_chr2_220096650_ENST00000323348_length(transcript)=2702nt_BP=445nt
GCGGCCAGCCAACCTTCGTAGCTATTGGCCGAACGGCCGTCGCTCTTCCTGCTGGGGAGTCGCCTACGCCTACTTCCTGCCGGGAGGAGG
GGCTCGAGTTCCGCGTCGTCGCGCAGAGCTGACTCTGGGAGGCGTTTGGGCCCAGAGAAGTGGATCCGCCGCTTGCGCCGCATGGAGTCC
GAATCGGAAAGCGGGGCTGCTGCTGACACCCCCCCACTGGAGACCCTAAGCTTCCATGGTGATGAAGAGATTATCGAGGTGGTAGAACTT
GATCCCGGTCCGCCGGACCCAGATGACCTGGCCCAGGAGATGGAAGATGTGGACTTTGAGGAAGAAGAGGAGGAAGAGGGCAACGAAGAG
GGCTGGGTTCTAGAACCCCAGGAAGGGGTGGTCGGCAGCATGGAGGGCCCCGACGATAGCGAGGTCACCTTTGCATTGCACTCAGGCTCA
GGGGAGAGAGAAAGCCCAGAAAGAAAGCTACTCCAGGGTCCTATGGATATTTCAGAGAAGTTATTTTGTTCAACTTGTGACCAGACCTTC
CAGAACCACCAAGAACAGAGGGAACATTATAAGCTTGACTGGCATCGGTTTAACCTAAAGCAACGTCTCAAGGACAAGCCTCTCCTGTCT
GCCCTGGACTTTGAAAAGCAGAGCTCCACAGGAGATCTTTCCAGCATCTCGGGATCAGAAGACTCAGACTCAGCCAGTGAGGAGGACTTG
CAGACACTGGATCGGGAGAGGGCTACATTTGAGAAGTTGAGCCGACCCCCAGGCTTTTACCCTCATCGAGTTCTTTTCCAGAATGCCCAG
GGCCAGTTTCTTTATGCCTACCGCTGTGTCCTAGGCCCTCATCAGGATCCCCCAGAAGAGGCAGAACTGCTGCTACAGAACCTGCAAAGT
AGAGGTCCCAGAGACTGCGTGGTGCTCATGGCTGCAGCTGGGCACTTTGCTGGTGCTATATTTCAAGGAAGAGAAGTGGTGACACACAAA
ACTTTTCACCGCTATACGGTTCGGGCCAAGCGGGGCACAGCCCAGGGGCTTCGGGATGCCCGAGGTGGGCCATCACACTCTGCTGGAGCC
AACCTGAGGCGCTACAATGAAGCCACACTATATAAGGATGTTCGTGACCTGCTGGCAGGGCCAAGCTGGGCTAAGGCGCTGGAGGAGGCT
GGTACAATACTGTTGCGTGCTCCCCGCTCTGGCCGGTCTTTGTTCTTTGGAGGCAAGGGAGCACCCCTGCAAAGGGGGGATCCCCGACTT
TGGGATATCCCCCTCGCCACCCGCAGACCCACCTTCCAAGAGCTACAGCGTGTGCTCCATAAGCTGACCACTTTGCATGTCTATGAAGAA
GACCCTCGGGAAGCAGTCAGACTGCACTCACCTCAGACACACTGGAAAACAGTAAGAGAGGAGAGAAAGAAGCCTACTGAGGAAGAAATA
AGAAAGATCTGCAGGGATGAAAAGGAAGCGCTGGGGCAGAATGAGGAATCTCCCAAACAGGGTTCAGGGTCGGAGGGAGAAGATGGCTTT
CAGGTAGAGTTGGAGCTAGTGGAGTTGACTGTGGGGACTCTGGATCTTTGTGAGTCTGAAGTATTGCCCAAGCGGAGGAGGAGAAAAAGG
AATAAGAAGGAGAAAAGCCGAGACCAGGAGGCTGGGGCACATCGGACTCTTCTCCAGCAAACTCAAGAAGAGGAGCCTTCCACACAGTCA
TCCCAGGCAGTTGCTGCCCCCTTGGGCCCTTTGCTGGATGAGGCCAAAGCCCCTGGTCAGCCAGAGCTCTGGAATGCACTGCTTGCTGCT
TGCCGAGCTGGAGATGTTGGAGTGCTAAAGCTGCAGCTAGCTCCCAGCCCTGCAGACCCTAGAGTTCTGTCTCTGCTCAGTGCCCCCTTG
GGCTCCGGTGGCTTTACTCTCCTGCATGCAGCAGCTGCAGCTGGAAGAGGCTCAGTGGTTCGTCTGCTGCTGGAAGCAGGTGCTGACCCC
ACTGTGCAGGACTCTCGGGCCCGGCCACCTTATACTGTTGCGGCTGACAAATCAACACGTAATGAGTTCCGAAGGTTCATGGAGAAGAAT
CCAGATGCCTACGATTACAACAAGGCTCAGGTGCCAGGACCATTGACACCAGAAATGGAGGCACGGCAGGCTACACGGAAAAGGGAGCAG
AAGGCAGCCCGGCGGCAACGGGAGGAACAGCAGCAGAGGCAGCAGGAGCAGGAGGAGCGTGAACGAGAAGAGCAGCGGCGATTTGCCGCC
CTCAGTGACCGAGAGAAGAGAGCTCTGGCTGCAGAGCGCCGACTCGCTGCCCAGTTGGGAGCCCCTACCTCTCCAATCCCTGACTCTGCA
ATCGTCAATACTCGACGCTGCTGGAGTTGTGGGGCATCCCTCCAAGGCCTGACTCCCTTTCACTACCTCGACTTCTCTTTCTGCTCCACA
CGTTGCCTCCAGGATCATCGCCGTCAGGCAGGGAGGCCCTCTTCCTGATCTCTTACAGCTCTACCTGGGGCCAACTCAGGGACCTGAGAG
GGCACATTCACAGCAGCCCTAGGTTTTTTCTTCCCCGTGAAACCAGAGATGATTTGGAAGATGGGGGTGAAGGACACTCGGGAACTAGGG
CAAAGACAGGGCTAGAGGTATGTGGAGCTGGTACTGTCTCTGGAATTTTAATCACAATAAAGTTTGGCAAGGAATGTGTACTTGTACTTA

>77_77_1_AAMP-ANKZF1_AAMP_chr2_219134105_ENST00000248450_ANKZF1_chr2_220096650_ENST00000323348_length(amino acids)=817AA_BP=140
MAERPSLFLLGSRLRLLPAGRRGSSSASSRRADSGRRLGPEKWIRRLRRMESESESGAAADTPPLETLSFHGDEEIIEVVELDPGPPDPD
DLAQEMEDVDFEEEEEEEGNEEGWVLEPQEGVVGSMEGPDDSEVTFALHSGSGERESPERKLLQGPMDISEKLFCSTCDQTFQNHQEQRE
HYKLDWHRFNLKQRLKDKPLLSALDFEKQSSTGDLSSISGSEDSDSASEEDLQTLDRERATFEKLSRPPGFYPHRVLFQNAQGQFLYAYR
CVLGPHQDPPEEAELLLQNLQSRGPRDCVVLMAAAGHFAGAIFQGREVVTHKTFHRYTVRAKRGTAQGLRDARGGPSHSAGANLRRYNEA
TLYKDVRDLLAGPSWAKALEEAGTILLRAPRSGRSLFFGGKGAPLQRGDPRLWDIPLATRRPTFQELQRVLHKLTTLHVYEEDPREAVRL
HSPQTHWKTVREERKKPTEEEIRKICRDEKEALGQNEESPKQGSGSEGEDGFQVELELVELTVGTLDLCESEVLPKRRRRKRNKKEKSRD
QEAGAHRTLLQQTQEEEPSTQSSQAVAAPLGPLLDEAKAPGQPELWNALLAACRAGDVGVLKLQLAPSPADPRVLSLLSAPLGSGGFTLL
HAAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNPDAYDYNKAQVPGPLTPEMEARQATRKREQKAARRQRE
EQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAAQLGAPTSPIPDSAIVNTRRCWSCGASLQGLTPFHYLDFSFCSTRCLQDHRR

--------------------------------------------------------------
>77_77_2_AAMP-ANKZF1_AAMP_chr2_219134105_ENST00000444053_ANKZF1_chr2_220096650_ENST00000323348_length(transcript)=2626nt_BP=369nt
CCGGGAGGAGGGGCTCGAGTTCCGCGTCGTCGCGCAGAGCTGACTCTGGGAGGCGTTTGGGCCCAGAGAAGTGGATCCGCCGCTTGCGCC
GCATGGAGTCCGAATCGGAAAGCGGGGCTGCTGCTGACACCCCCCCACTGGAGACCCTAAGCTTCCATGGTGATGAAGAGATTATCGAGG
TGGTAGAACTTGATCCCGGTCCGCCGGACCCAGCAGATGACCTGGCCCAGGAGATGGAAGATGTGGACTTTGAGGAAGAAGAGGAGGAAG
AGGGCAACGAAGAGGGCTGGGTTCTAGAACCCCAGGAAGGGGTGGTCGGCAGCATGGAGGGCCCCGACGATAGCGAGGTCACCTTTGCAT
TGCACTCAGGCTCAGGGGAGAGAGAAAGCCCAGAAAGAAAGCTACTCCAGGGTCCTATGGATATTTCAGAGAAGTTATTTTGTTCAACTT
GTGACCAGACCTTCCAGAACCACCAAGAACAGAGGGAACATTATAAGCTTGACTGGCATCGGTTTAACCTAAAGCAACGTCTCAAGGACA
AGCCTCTCCTGTCTGCCCTGGACTTTGAAAAGCAGAGCTCCACAGGAGATCTTTCCAGCATCTCGGGATCAGAAGACTCAGACTCAGCCA
GTGAGGAGGACTTGCAGACACTGGATCGGGAGAGGGCTACATTTGAGAAGTTGAGCCGACCCCCAGGCTTTTACCCTCATCGAGTTCTTT
TCCAGAATGCCCAGGGCCAGTTTCTTTATGCCTACCGCTGTGTCCTAGGCCCTCATCAGGATCCCCCAGAAGAGGCAGAACTGCTGCTAC
AGAACCTGCAAAGTAGAGGTCCCAGAGACTGCGTGGTGCTCATGGCTGCAGCTGGGCACTTTGCTGGTGCTATATTTCAAGGAAGAGAAG
TGGTGACACACAAAACTTTTCACCGCTATACGGTTCGGGCCAAGCGGGGCACAGCCCAGGGGCTTCGGGATGCCCGAGGTGGGCCATCAC
ACTCTGCTGGAGCCAACCTGAGGCGCTACAATGAAGCCACACTATATAAGGATGTTCGTGACCTGCTGGCAGGGCCAAGCTGGGCTAAGG
CGCTGGAGGAGGCTGGTACAATACTGTTGCGTGCTCCCCGCTCTGGCCGGTCTTTGTTCTTTGGAGGCAAGGGAGCACCCCTGCAAAGGG
GGGATCCCCGACTTTGGGATATCCCCCTCGCCACCCGCAGACCCACCTTCCAAGAGCTACAGCGTGTGCTCCATAAGCTGACCACTTTGC
ATGTCTATGAAGAAGACCCTCGGGAAGCAGTCAGACTGCACTCACCTCAGACACACTGGAAAACAGTAAGAGAGGAGAGAAAGAAGCCTA
CTGAGGAAGAAATAAGAAAGATCTGCAGGGATGAAAAGGAAGCGCTGGGGCAGAATGAGGAATCTCCCAAACAGGGTTCAGGGTCGGAGG
GAGAAGATGGCTTTCAGGTAGAGTTGGAGCTAGTGGAGTTGACTGTGGGGACTCTGGATCTTTGTGAGTCTGAAGTATTGCCCAAGCGGA
GGAGGAGAAAAAGGAATAAGAAGGAGAAAAGCCGAGACCAGGAGGCTGGGGCACATCGGACTCTTCTCCAGCAAACTCAAGAAGAGGAGC
CTTCCACACAGTCATCCCAGGCAGTTGCTGCCCCCTTGGGCCCTTTGCTGGATGAGGCCAAAGCCCCTGGTCAGCCAGAGCTCTGGAATG
CACTGCTTGCTGCTTGCCGAGCTGGAGATGTTGGAGTGCTAAAGCTGCAGCTAGCTCCCAGCCCTGCAGACCCTAGAGTTCTGTCTCTGC
TCAGTGCCCCCTTGGGCTCCGGTGGCTTTACTCTCCTGCATGCAGCAGCTGCAGCTGGAAGAGGCTCAGTGGTTCGTCTGCTGCTGGAAG
CAGGTGCTGACCCCACTGTGCAGGACTCTCGGGCCCGGCCACCTTATACTGTTGCGGCTGACAAATCAACACGTAATGAGTTCCGAAGGT
TCATGGAGAAGAATCCAGATGCCTACGATTACAACAAGGCTCAGGTGCCAGGACCATTGACACCAGAAATGGAGGCACGGCAGGCTACAC
GGAAAAGGGAGCAGAAGGCAGCCCGGCGGCAACGGGAGGAACAGCAGCAGAGGCAGCAGGAGCAGGAGGAGCGTGAACGAGAAGAGCAGC
GGCGATTTGCCGCCCTCAGTGACCGAGAGAAGAGAGCTCTGGCTGCAGAGCGCCGACTCGCTGCCCAGTTGGGAGCCCCTACCTCTCCAA
TCCCTGACTCTGCAATCGTCAATACTCGACGCTGCTGGAGTTGTGGGGCATCCCTCCAAGGCCTGACTCCCTTTCACTACCTCGACTTCT
CTTTCTGCTCCACACGTTGCCTCCAGGATCATCGCCGTCAGGCAGGGAGGCCCTCTTCCTGATCTCTTACAGCTCTACCTGGGGCCAACT
CAGGGACCTGAGAGGGCACATTCACAGCAGCCCTAGGTTTTTTCTTCCCCGTGAAACCAGAGATGATTTGGAAGATGGGGGTGAAGGACA
CTCGGGAACTAGGGCAAAGACAGGGCTAGAGGTATGTGGAGCTGGTACTGTCTCTGGAATTTTAATCACAATAAAGTTTGGCAAGGAATG

>77_77_2_AAMP-ANKZF1_AAMP_chr2_219134105_ENST00000444053_ANKZF1_chr2_220096650_ENST00000323348_length(amino acids)=781AA_BP=104
MGPEKWIRRLRRMESESESGAAADTPPLETLSFHGDEEIIEVVELDPGPPDPADDLAQEMEDVDFEEEEEEEGNEEGWVLEPQEGVVGSM
EGPDDSEVTFALHSGSGERESPERKLLQGPMDISEKLFCSTCDQTFQNHQEQREHYKLDWHRFNLKQRLKDKPLLSALDFEKQSSTGDLS
SISGSEDSDSASEEDLQTLDRERATFEKLSRPPGFYPHRVLFQNAQGQFLYAYRCVLGPHQDPPEEAELLLQNLQSRGPRDCVVLMAAAG
HFAGAIFQGREVVTHKTFHRYTVRAKRGTAQGLRDARGGPSHSAGANLRRYNEATLYKDVRDLLAGPSWAKALEEAGTILLRAPRSGRSL
FFGGKGAPLQRGDPRLWDIPLATRRPTFQELQRVLHKLTTLHVYEEDPREAVRLHSPQTHWKTVREERKKPTEEEIRKICRDEKEALGQN
EESPKQGSGSEGEDGFQVELELVELTVGTLDLCESEVLPKRRRRKRNKKEKSRDQEAGAHRTLLQQTQEEEPSTQSSQAVAAPLGPLLDE
AKAPGQPELWNALLAACRAGDVGVLKLQLAPSPADPRVLSLLSAPLGSGGFTLLHAAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVA
ADKSTRNEFRRFMEKNPDAYDYNKAQVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AAMP-ANKZF1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for AAMP-ANKZF1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for AAMP-ANKZF1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source