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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RPL8-FAF1 (FusionGDB2 ID:77042)

Fusion Gene Summary for RPL8-FAF1

check button Fusion gene summary
Fusion gene informationFusion gene name: RPL8-FAF1
Fusion gene ID: 77042
HgeneTgene
Gene symbol

RPL8

FAF1

Gene ID

6132

11124

Gene nameribosomal protein L8Fas associated factor 1
SynonymsL8CGI-03|HFAF1s|UBXD12|UBXN3A|hFAF1
Cytomap

8q24.3

1p32.3

Type of geneprotein-codingprotein-coding
Description60S ribosomal protein L8large ribosomal subunit protein uL2FAS-associated factor 1Fas (TNFRSF6) associated factor 1TNFRSF6-associated factor 1UBX domain protein 3AUBX domain-containing protein 12UBX domain-containing protein 3A
Modification date2020032720200313
UniProtAcc.

Q9UNN5

Ensembl transtripts involved in fusion geneENST00000262584, ENST00000394920, 
ENST00000527914, ENST00000528957, 
ENST00000529163, 
ENST00000472808, 
ENST00000371778, ENST00000396153, 
ENST00000545823, 
Fusion gene scores* DoF score36 X 18 X 15=972028 X 23 X 14=9016
# samples 3731
** MAII scorelog2(37/9720*10)=-4.71535913797683
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(31/9016*10)=-4.86214739489798
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPL8 [Title/Abstract] AND FAF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRPL8(146017377)-FAF1(51061888), # samples:1
Anticipated loss of major functional domain due to fusion event.RPL8-FAF1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
RPL8-FAF1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPL8

GO:0002181

cytoplasmic translation

25957688

TgeneFAF1

GO:0010942

positive regulation of cell death

15596450


check buttonFusion gene breakpoints across RPL8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FAF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8077-01ARPL8chr8

146017377

-FAF1chr1

51061888

-


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Fusion Gene ORF analysis for RPL8-FAF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000262584ENST00000472808RPL8chr8

146017377

-FAF1chr1

51061888

-
5CDS-5UTRENST00000394920ENST00000472808RPL8chr8

146017377

-FAF1chr1

51061888

-
5CDS-5UTRENST00000527914ENST00000472808RPL8chr8

146017377

-FAF1chr1

51061888

-
5CDS-5UTRENST00000528957ENST00000472808RPL8chr8

146017377

-FAF1chr1

51061888

-
Frame-shiftENST00000394920ENST00000371778RPL8chr8

146017377

-FAF1chr1

51061888

-
Frame-shiftENST00000394920ENST00000396153RPL8chr8

146017377

-FAF1chr1

51061888

-
Frame-shiftENST00000394920ENST00000545823RPL8chr8

146017377

-FAF1chr1

51061888

-
In-frameENST00000262584ENST00000371778RPL8chr8

146017377

-FAF1chr1

51061888

-
In-frameENST00000262584ENST00000396153RPL8chr8

146017377

-FAF1chr1

51061888

-
In-frameENST00000262584ENST00000545823RPL8chr8

146017377

-FAF1chr1

51061888

-
In-frameENST00000527914ENST00000371778RPL8chr8

146017377

-FAF1chr1

51061888

-
In-frameENST00000527914ENST00000396153RPL8chr8

146017377

-FAF1chr1

51061888

-
In-frameENST00000527914ENST00000545823RPL8chr8

146017377

-FAF1chr1

51061888

-
In-frameENST00000528957ENST00000371778RPL8chr8

146017377

-FAF1chr1

51061888

-
In-frameENST00000528957ENST00000396153RPL8chr8

146017377

-FAF1chr1

51061888

-
In-frameENST00000528957ENST00000545823RPL8chr8

146017377

-FAF1chr1

51061888

-
intron-3CDSENST00000529163ENST00000371778RPL8chr8

146017377

-FAF1chr1

51061888

-
intron-3CDSENST00000529163ENST00000396153RPL8chr8

146017377

-FAF1chr1

51061888

-
intron-3CDSENST00000529163ENST00000545823RPL8chr8

146017377

-FAF1chr1

51061888

-
intron-5UTRENST00000529163ENST00000472808RPL8chr8

146017377

-FAF1chr1

51061888

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000527914RPL8chr8146017377-ENST00000396153FAF1chr151061888-3378207691415448
ENST00000527914RPL8chr8146017377-ENST00000371778FAF1chr151061888-1819207691415448
ENST00000527914RPL8chr8146017377-ENST00000545823FAF1chr151061888-1583207691415448
ENST00000262584RPL8chr8146017377-ENST00000396153FAF1chr151061888-35423712331579448
ENST00000262584RPL8chr8146017377-ENST00000371778FAF1chr151061888-19833712331579448
ENST00000262584RPL8chr8146017377-ENST00000545823FAF1chr151061888-17473712331579448
ENST00000528957RPL8chr8146017377-ENST00000396153FAF1chr151061888-35313601591568469
ENST00000528957RPL8chr8146017377-ENST00000371778FAF1chr151061888-19723601591568469
ENST00000528957RPL8chr8146017377-ENST00000545823FAF1chr151061888-17363601591568469

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000527914ENST00000396153RPL8chr8146017377-FAF1chr151061888-0.0005128660.99948716
ENST00000527914ENST00000371778RPL8chr8146017377-FAF1chr151061888-0.0011940520.998806
ENST00000527914ENST00000545823RPL8chr8146017377-FAF1chr151061888-0.0013570380.998643
ENST00000262584ENST00000396153RPL8chr8146017377-FAF1chr151061888-0.0005515980.99944836
ENST00000262584ENST00000371778RPL8chr8146017377-FAF1chr151061888-0.0013517910.9986482
ENST00000262584ENST00000545823RPL8chr8146017377-FAF1chr151061888-0.0015303590.99846965
ENST00000528957ENST00000396153RPL8chr8146017377-FAF1chr151061888-0.0005134810.99948645
ENST00000528957ENST00000371778RPL8chr8146017377-FAF1chr151061888-0.0011517280.9988482
ENST00000528957ENST00000545823RPL8chr8146017377-FAF1chr151061888-0.0012099470.9987901

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Fusion Genomic Features for RPL8-FAF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RPL8-FAF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:146017377/chr1:51061888)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FAF1

Q9UNN5

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Ubiquitin-binding protein (PubMed:19722279). Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (PubMed:26842564). Potentiates but cannot initiate FAS-induced apoptosis (By similarity). {ECO:0000250|UniProtKB:P54731, ECO:0000269|PubMed:19722279, ECO:0000269|PubMed:26842564}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFAF1chr8:146017377chr1:51061888ENST00000371778820569_646248651.0DomainUBX
TgeneFAF1chr8:146017377chr1:51061888ENST00000396153719569_646248651.0DomainUBX

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFAF1chr8:146017377chr1:51061888ENST000003717788201_57248651.0DomainUBA
TgeneFAF1chr8:146017377chr1:51061888ENST000003961537191_57248651.0DomainUBA


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Fusion Gene Sequence for RPL8-FAF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>77042_77042_1_RPL8-FAF1_RPL8_chr8_146017377_ENST00000262584_FAF1_chr1_51061888_ENST00000371778_length(transcript)=1983nt_BP=371nt
ACCAGGACACCTTCAGCCGCGTCTCCTGGTGCGCCTGCGCGGGGGCCCTGGAGGAGGAGAAGTAGGCGGGGCCGGCGGCCGCTGGTGACT
ACAAGCCCCGGCGTGCACCGCGCTAGGCTGGCCGTGGCGCGCCCGGAAGGTGTCGCGGCCCTGGGCCCCGCCCCGGAAGATAAGGCCGCT
CGCTGACGCCGTGTTTCCTCTTTCGGCCGCGCTGGTGAACAGGACCCGTCGCCATGGGCCGTGTGATCCGTGGACAGAGGAAGGGCGCCG
GGTCTGTGTTCCGCGCGCACGTGAAGCACCGTAAAGGCGCTGCGCGCCTGCGCGCCGTGGATTTCGCTGAGCGGCACGGCTACATCAAGG
GCATCGTCAAGATGTGTCTTGCTGAATCAGGGCTCTCTTATCCCTGCCATCGACTTACAGTGGGAAGAAGATCTTCACCTGCACAGACCC
GGGAACAGTCGGAAGAACAAATCACCGATGTTCATATGGTTAGTGATAGCGATGGAGATGACTTTGAAGATGCTACAGAATTTGGGGTGG
ATGATGGAGAAGTATTTGGCATGGCGTCATCTGCCTTGAGAAAATCTCCAATGATGCCAGAAAACGCAGAAAATGAAGGAGATGCCTTAT
TACAATTTACAGCAGAGTTTTCTTCAAGATATGGTGATTGCCATCCTGTATTTTTTATTGGCTCATTAGAAGCTGCTTTTCAAGAGGCCT
TCTATGTGAAAGCCCGAGATAGAAAGCTTCTTGCTATCTACCTCCACCATGATGAAAGTGTGTTAACCAACGTGTTCTGCTCACAAATGC
TTTGTGCTGAATCCATTGTTTCTTATCTGAGTCAAAATTTTATAACCTGGGCTTGGGATCTGACAAAGGACTCCAACAGAGCAAGATTTC
TCACTATGTGCAATAGACACTTTGGCAGTGTTGTGGCACAAACCATTCGGACTCAAAAAACGGATCAGTTTCCGCTTTTCCTGATTATTA
TGGGAAAGCGATCATCTAATGAAGTGTTGAATGTGATACAAGGGAACACAACAGTAGATGAGTTAATGATGAGACTCATGGCTGCAATGG
AGATCTTCACAGCCCAACAACAGGAAGATATAAAGGACGAGGATGAACGTGAAGCCAGAGAAAATGTGAAGAGAGAGCAAGATGAGGCCT
ATCGCCTTTCACTTGAGGCTGACAGAGCAAAGAGGGAAGCTCACGAGAGAGAGATGGCAGAACAGTTTCGTTTGGAGCAGATTCGCAAAG
AACAAGAAGAGGAACGTGAGGCCATCCGGCTGTCCTTAGAGCAAGCCCTGCCTCCTGAGCCAAAGGAAGAAAATGCTGAGCCTGTGAGCA
AACTGCGGATCCGGACCCCCAGTGGCGAGTTCTTGGAGCGGCGTTTCCTGGCCAGCAACAAGCTCCAGATTGTCTTTGATTTTGTAGCTT
CCAAAGGATTTCCATGGGATGAGTACAAGTTACTGAGCACCTTTCCTAGGAGAGACGTAACTCAACTGGACCCAAATAAATCATTATTGG
AGGTAAAGTTGTTCCCTCAAGAAACCCTTTTCCTTGAAGCAAAAGAGTAAACACGGCCCAGCGGTGGAACCAGCCATTCCTTGACAAGCC
AGCAGCCTGCGTCAGGAGAAGGGCTCCTCGCCAACCCACCCACACGCTCGTCTCACTCAATTCAATGTCACACTTCTGCCTCTTGCAAAA
TTGCTGGAAAAAGTAATAATAAATATAGCTACTTAAGATTTCCCATCCATGAGTATATATTCCCAACCCTTATTACAGAGAATTACAACT
CTGCCACCCTCCCCTACCCCCTGCACTTCACCCTCCTTCAATGACGAATGCATTGTTCAAGTGTGAGTGATCACTAAATAGAATTTTTAC
CTCTCCAGTGCCCATCTTTTCCCCACAGTGTCTAGGACAGTTCTGTCTGTTCTGTGACACCAGGATGCTGTATATTTGATATATGTCTTT

>77042_77042_1_RPL8-FAF1_RPL8_chr8_146017377_ENST00000262584_FAF1_chr1_51061888_ENST00000371778_length(amino acids)=448AA_BP=46
MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKMCLAESGLSYPCHRLTVGRRSSPAQTREQSEEQITDVHMVSDSD
GDDFEDATEFGVDDGEVFGMASSALRKSPMMPENAENEGDALLQFTAEFSSRYGDCHPVFFIGSLEAAFQEAFYVKARDRKLLAIYLHHD
ESVLTNVFCSQMLCAESIVSYLSQNFITWAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTQKTDQFPLFLIIMGKRSSNEVLNVIQGNTT
VDELMMRLMAAMEIFTAQQQEDIKDEDEREARENVKREQDEAYRLSLEADRAKREAHEREMAEQFRLEQIRKEQEEEREAIRLSLEQALP

--------------------------------------------------------------
>77042_77042_2_RPL8-FAF1_RPL8_chr8_146017377_ENST00000262584_FAF1_chr1_51061888_ENST00000396153_length(transcript)=3542nt_BP=371nt
ACCAGGACACCTTCAGCCGCGTCTCCTGGTGCGCCTGCGCGGGGGCCCTGGAGGAGGAGAAGTAGGCGGGGCCGGCGGCCGCTGGTGACT
ACAAGCCCCGGCGTGCACCGCGCTAGGCTGGCCGTGGCGCGCCCGGAAGGTGTCGCGGCCCTGGGCCCCGCCCCGGAAGATAAGGCCGCT
CGCTGACGCCGTGTTTCCTCTTTCGGCCGCGCTGGTGAACAGGACCCGTCGCCATGGGCCGTGTGATCCGTGGACAGAGGAAGGGCGCCG
GGTCTGTGTTCCGCGCGCACGTGAAGCACCGTAAAGGCGCTGCGCGCCTGCGCGCCGTGGATTTCGCTGAGCGGCACGGCTACATCAAGG
GCATCGTCAAGATGTGTCTTGCTGAATCAGGGCTCTCTTATCCCTGCCATCGACTTACAGTGGGAAGAAGATCTTCACCTGCACAGACCC
GGGAACAGTCGGAAGAACAAATCACCGATGTTCATATGGTTAGTGATAGCGATGGAGATGACTTTGAAGATGCTACAGAATTTGGGGTGG
ATGATGGAGAAGTATTTGGCATGGCGTCATCTGCCTTGAGAAAATCTCCAATGATGCCAGAAAACGCAGAAAATGAAGGAGATGCCTTAT
TACAATTTACAGCAGAGTTTTCTTCAAGATATGGTGATTGCCATCCTGTATTTTTTATTGGCTCATTAGAAGCTGCTTTTCAAGAGGCCT
TCTATGTGAAAGCCCGAGATAGAAAGCTTCTTGCTATCTACCTCCACCATGATGAAAGTGTGTTAACCAACGTGTTCTGCTCACAAATGC
TTTGTGCTGAATCCATTGTTTCTTATCTGAGTCAAAATTTTATAACCTGGGCTTGGGATCTGACAAAGGACTCCAACAGAGCAAGATTTC
TCACTATGTGCAATAGACACTTTGGCAGTGTTGTGGCACAAACCATTCGGACTCAAAAAACGGATCAGTTTCCGCTTTTCCTGATTATTA
TGGGAAAGCGATCATCTAATGAAGTGTTGAATGTGATACAAGGGAACACAACAGTAGATGAGTTAATGATGAGACTCATGGCTGCAATGG
AGATCTTCACAGCCCAACAACAGGAAGATATAAAGGACGAGGATGAACGTGAAGCCAGAGAAAATGTGAAGAGAGAGCAAGATGAGGCCT
ATCGCCTTTCACTTGAGGCTGACAGAGCAAAGAGGGAAGCTCACGAGAGAGAGATGGCAGAACAGTTTCGTTTGGAGCAGATTCGCAAAG
AACAAGAAGAGGAACGTGAGGCCATCCGGCTGTCCTTAGAGCAAGCCCTGCCTCCTGAGCCAAAGGAAGAAAATGCTGAGCCTGTGAGCA
AACTGCGGATCCGGACCCCCAGTGGCGAGTTCTTGGAGCGGCGTTTCCTGGCCAGCAACAAGCTCCAGATTGTCTTTGATTTTGTAGCTT
CCAAAGGATTTCCATGGGATGAGTACAAGTTACTGAGCACCTTTCCTAGGAGAGACGTAACTCAACTGGACCCAAATAAATCATTATTGG
AGGTAAAGTTGTTCCCTCAAGAAACCCTTTTCCTTGAAGCAAAAGAGTAAACACGGCCCAGCGGTGGAACCAGCCATTCCTTGACAAGCC
AGCAGCCTGCGTCAGGAGAAGGGCTCCTCGCCAACCCACCCACACGCTCGTCTCACTCAATTCAATGTCACACTTCTGCCTCTTGCAAAA
TTGCTGGAAAAAGTAATAATAAATATAGCTACTTAAGATTTCCCATCCATGAGTATATATTCCCAACCCTTATTACAGAGAATTACAACT
CTGCCACCCTCCCCTACCCCCTGCACTTCACCCTCCTTCAATGACGAATGCATTGTTCAAGTGTGAGTGATCACTAAATAGAATTTTTAC
CTCTCCAGTGCCCATCTTTTCCCCACAGTGTCTAGGACAGTTCTGTCTGTTCTGTGACACCAGGATGCTGTATATTTGATATATGTCTTT
TTATTTTCATGACTGAATTTCTACTTCATCACCTAATTTTAAGGGGCAGAGGGAAAAAAAGTCAAATGAGACATTGTCGGCATGGAGATT
AAACATTGTAGGAAAAAAGTATACCATTTTTGTTAGAACTTTCTGATGGCTTTACTAAGATGTCAGGTTTTGTTTGAGGACTGAATTTGA
CATATATGCAAGATATTTATTTACTGCTGCTGCCTTGGGTCTCCAGGTTCTACCTAGGAGGTATTTGCTGTTCCATTGCAGCATAGGGAA
ACTGTTCAAGCACACAATGTGAATGTTGAGATCATGTGCAGAGAGGCCAGTACCAAAACTTCAGTATCTGGCCCAATGGCAAGAGGCTAC
TGTTAGGTTTGCATTTGGGCAGTTAGAACCTCACAGATACCAGCTCCCAAGTTGCTAGTCCATCAGTGTAAACTGAACACAATTCTCTCT
TGCTTTCTCTCTCTCTACTCCCTCACACATTTGGACCTTGTCACTTGGTGTTTAAGCACCTTGCCTATCAACAAAATCTGATGAGCAGCC
CCATGGACTCTCCTGTAATAAGGAACTTGCTCTACTATTTTATTCTTTTAATGTTTTAGTATTTGATATTGGACTCAAATGAAAGGGATC
TCATTCTGTGGCTGAAAAATCAGACTTCATATGTTGAAGAGAGCAAACTTGGGGACTCAACTCAGAAGACATGTGTTGCCTGAAACCTGC
ATATAATAATTTTTGATTTGATTTAGTAAGTGTGGATTTTTCTTAATCTACAGATTTGGGGTTTGGGGTTTAGATCATGAGAACACCGTT
TATACCTTCACAGCCAATGATTTATTTTTAGTCTTGAAATATTTCTCCATATCTGTTTTTGTGTCACCTGTGGGTTTTATCCTAGGGGTT
GGGATCCTGATTTTAACATTTTGTACTTGTCCAAAAAAGAGTTCAAATGCTGGGTTTGTTCCCCCAGCCTCGGCCAAGGGGTTCTCAGAA
GATTCTAACCAAAGCTGGAGATAGGTCTGCTCATTTTCCTTCTGCCCAGAAGTGGATGTTGGCCAGGAAAATTACACCTTGTGTCTTCTC
TGATGCTCCAACCAGGGACCTCTCCAGATTACTATCTAGCACAGACTAGTGCTACATCTGCCTAGGTATGGGCTTTCTCTGGCAGCAGGG
GTCTCTCTAGGGAGGCTGAGAGACCCATGGGTCTCCCTTCAGGGGAAGTGTTCAGGGGAGTTCAAACTGAACACTTCTCTCCAGCTCTAT
TCCTATCTTCCTAATCTAATGGCTCTACAAGATAGTCATTTCCAGTGCTACAGATGCACCAGGGCACCACCTCTTTTTTTTTCTAGGTAG
ACCTTGTTCTGTAGCTGCTGTGAAGAAGCTGCAGCCCTGAACTCAGGTCATACTCAGGAACAGCAGCAGGGGTGTGGGTGGGGTTTGAGG
GAAGGTACTCTGAATTCACCTTCATGTTTAACCTGTTCCATCTGACTTGGGTTTCTTCATTATATTGTTCCCTCCCACTCACCTTCACTT

>77042_77042_2_RPL8-FAF1_RPL8_chr8_146017377_ENST00000262584_FAF1_chr1_51061888_ENST00000396153_length(amino acids)=448AA_BP=46
MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKMCLAESGLSYPCHRLTVGRRSSPAQTREQSEEQITDVHMVSDSD
GDDFEDATEFGVDDGEVFGMASSALRKSPMMPENAENEGDALLQFTAEFSSRYGDCHPVFFIGSLEAAFQEAFYVKARDRKLLAIYLHHD
ESVLTNVFCSQMLCAESIVSYLSQNFITWAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTQKTDQFPLFLIIMGKRSSNEVLNVIQGNTT
VDELMMRLMAAMEIFTAQQQEDIKDEDEREARENVKREQDEAYRLSLEADRAKREAHEREMAEQFRLEQIRKEQEEEREAIRLSLEQALP

--------------------------------------------------------------
>77042_77042_3_RPL8-FAF1_RPL8_chr8_146017377_ENST00000262584_FAF1_chr1_51061888_ENST00000545823_length(transcript)=1747nt_BP=371nt
ACCAGGACACCTTCAGCCGCGTCTCCTGGTGCGCCTGCGCGGGGGCCCTGGAGGAGGAGAAGTAGGCGGGGCCGGCGGCCGCTGGTGACT
ACAAGCCCCGGCGTGCACCGCGCTAGGCTGGCCGTGGCGCGCCCGGAAGGTGTCGCGGCCCTGGGCCCCGCCCCGGAAGATAAGGCCGCT
CGCTGACGCCGTGTTTCCTCTTTCGGCCGCGCTGGTGAACAGGACCCGTCGCCATGGGCCGTGTGATCCGTGGACAGAGGAAGGGCGCCG
GGTCTGTGTTCCGCGCGCACGTGAAGCACCGTAAAGGCGCTGCGCGCCTGCGCGCCGTGGATTTCGCTGAGCGGCACGGCTACATCAAGG
GCATCGTCAAGATGTGTCTTGCTGAATCAGGGCTCTCTTATCCCTGCCATCGACTTACAGTGGGAAGAAGATCTTCACCTGCACAGACCC
GGGAACAGTCGGAAGAACAAATCACCGATGTTCATATGGTTAGTGATAGCGATGGAGATGACTTTGAAGATGCTACAGAATTTGGGGTGG
ATGATGGAGAAGTATTTGGCATGGCGTCATCTGCCTTGAGAAAATCTCCAATGATGCCAGAAAACGCAGAAAATGAAGGAGATGCCTTAT
TACAATTTACAGCAGAGTTTTCTTCAAGATATGGTGATTGCCATCCTGTATTTTTTATTGGCTCATTAGAAGCTGCTTTTCAAGAGGCCT
TCTATGTGAAAGCCCGAGATAGAAAGCTTCTTGCTATCTACCTCCACCATGATGAAAGTGTGTTAACCAACGTGTTCTGCTCACAAATGC
TTTGTGCTGAATCCATTGTTTCTTATCTGAGTCAAAATTTTATAACCTGGGCTTGGGATCTGACAAAGGACTCCAACAGAGCAAGATTTC
TCACTATGTGCAATAGACACTTTGGCAGTGTTGTGGCACAAACCATTCGGACTCAAAAAACGGATCAGTTTCCGCTTTTCCTGATTATTA
TGGGAAAGCGATCATCTAATGAAGTGTTGAATGTGATACAAGGGAACACAACAGTAGATGAGTTAATGATGAGACTCATGGCTGCAATGG
AGATCTTCACAGCCCAACAACAGGAAGATATAAAGGACGAGGATGAACGTGAAGCCAGAGAAAATGTGAAGAGAGAGCAAGATGAGGCCT
ATCGCCTTTCACTTGAGGCTGACAGAGCAAAGAGGGAAGCTCACGAGAGAGAGATGGCAGAACAGTTTCGTTTGGAGCAGATTCGCAAAG
AACAAGAAGAGGAACGTGAGGCCATCCGGCTGTCCTTAGAGCAAGCCCTGCCTCCTGAGCCAAAGGAAGAAAATGCTGAGCCTGTGAGCA
AACTGCGGATCCGGACCCCCAGTGGCGAGTTCTTGGAGCGGCGTTTCCTGGCCAGCAACAAGCTCCAGATTGTCTTTGATTTTGTAGCTT
CCAAAGGATTTCCATGGGATGAGTACAAGTTACTGAGCACCTTTCCTAGGAGAGACGTAACTCAACTGGACCCAAATAAATCATTATTGG
AGGTAAAGTTGTTCCCTCAAGAAACCCTTTTCCTTGAAGCAAAAGAGTAAACACGGCCCAGCGGTGGAACCAGCCATTCCTTGACAAGCC
AGCAGCCTGCGTCAGGAGAAGGGCTCCTCGCCAACCCACCCACACGCTCGTCTCACTCAATTCAATGTCACACTTCTGCCTCTTGCAAAA

>77042_77042_3_RPL8-FAF1_RPL8_chr8_146017377_ENST00000262584_FAF1_chr1_51061888_ENST00000545823_length(amino acids)=448AA_BP=46
MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKMCLAESGLSYPCHRLTVGRRSSPAQTREQSEEQITDVHMVSDSD
GDDFEDATEFGVDDGEVFGMASSALRKSPMMPENAENEGDALLQFTAEFSSRYGDCHPVFFIGSLEAAFQEAFYVKARDRKLLAIYLHHD
ESVLTNVFCSQMLCAESIVSYLSQNFITWAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTQKTDQFPLFLIIMGKRSSNEVLNVIQGNTT
VDELMMRLMAAMEIFTAQQQEDIKDEDEREARENVKREQDEAYRLSLEADRAKREAHEREMAEQFRLEQIRKEQEEEREAIRLSLEQALP

--------------------------------------------------------------
>77042_77042_4_RPL8-FAF1_RPL8_chr8_146017377_ENST00000527914_FAF1_chr1_51061888_ENST00000371778_length(transcript)=1819nt_BP=207nt
GGAAGATAAGGCCGCTCGCTGACGCCGTGTTTCCTCTTTCGGCCGCGCTGGTGAACAGGACCCGTCGCCATGGGCCGTGTGATCCGTGGA
CAGAGGAAGGGCGCCGGGTCTGTGTTCCGCGCGCACGTGAAGCACCGTAAAGGCGCTGCGCGCCTGCGCGCCGTGGATTTCGCTGAGCGG
CACGGCTACATCAAGGGCATCGTCAAGATGTGTCTTGCTGAATCAGGGCTCTCTTATCCCTGCCATCGACTTACAGTGGGAAGAAGATCT
TCACCTGCACAGACCCGGGAACAGTCGGAAGAACAAATCACCGATGTTCATATGGTTAGTGATAGCGATGGAGATGACTTTGAAGATGCT
ACAGAATTTGGGGTGGATGATGGAGAAGTATTTGGCATGGCGTCATCTGCCTTGAGAAAATCTCCAATGATGCCAGAAAACGCAGAAAAT
GAAGGAGATGCCTTATTACAATTTACAGCAGAGTTTTCTTCAAGATATGGTGATTGCCATCCTGTATTTTTTATTGGCTCATTAGAAGCT
GCTTTTCAAGAGGCCTTCTATGTGAAAGCCCGAGATAGAAAGCTTCTTGCTATCTACCTCCACCATGATGAAAGTGTGTTAACCAACGTG
TTCTGCTCACAAATGCTTTGTGCTGAATCCATTGTTTCTTATCTGAGTCAAAATTTTATAACCTGGGCTTGGGATCTGACAAAGGACTCC
AACAGAGCAAGATTTCTCACTATGTGCAATAGACACTTTGGCAGTGTTGTGGCACAAACCATTCGGACTCAAAAAACGGATCAGTTTCCG
CTTTTCCTGATTATTATGGGAAAGCGATCATCTAATGAAGTGTTGAATGTGATACAAGGGAACACAACAGTAGATGAGTTAATGATGAGA
CTCATGGCTGCAATGGAGATCTTCACAGCCCAACAACAGGAAGATATAAAGGACGAGGATGAACGTGAAGCCAGAGAAAATGTGAAGAGA
GAGCAAGATGAGGCCTATCGCCTTTCACTTGAGGCTGACAGAGCAAAGAGGGAAGCTCACGAGAGAGAGATGGCAGAACAGTTTCGTTTG
GAGCAGATTCGCAAAGAACAAGAAGAGGAACGTGAGGCCATCCGGCTGTCCTTAGAGCAAGCCCTGCCTCCTGAGCCAAAGGAAGAAAAT
GCTGAGCCTGTGAGCAAACTGCGGATCCGGACCCCCAGTGGCGAGTTCTTGGAGCGGCGTTTCCTGGCCAGCAACAAGCTCCAGATTGTC
TTTGATTTTGTAGCTTCCAAAGGATTTCCATGGGATGAGTACAAGTTACTGAGCACCTTTCCTAGGAGAGACGTAACTCAACTGGACCCA
AATAAATCATTATTGGAGGTAAAGTTGTTCCCTCAAGAAACCCTTTTCCTTGAAGCAAAAGAGTAAACACGGCCCAGCGGTGGAACCAGC
CATTCCTTGACAAGCCAGCAGCCTGCGTCAGGAGAAGGGCTCCTCGCCAACCCACCCACACGCTCGTCTCACTCAATTCAATGTCACACT
TCTGCCTCTTGCAAAATTGCTGGAAAAAGTAATAATAAATATAGCTACTTAAGATTTCCCATCCATGAGTATATATTCCCAACCCTTATT
ACAGAGAATTACAACTCTGCCACCCTCCCCTACCCCCTGCACTTCACCCTCCTTCAATGACGAATGCATTGTTCAAGTGTGAGTGATCAC
TAAATAGAATTTTTACCTCTCCAGTGCCCATCTTTTCCCCACAGTGTCTAGGACAGTTCTGTCTGTTCTGTGACACCAGGATGCTGTATA

>77042_77042_4_RPL8-FAF1_RPL8_chr8_146017377_ENST00000527914_FAF1_chr1_51061888_ENST00000371778_length(amino acids)=448AA_BP=46
MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKMCLAESGLSYPCHRLTVGRRSSPAQTREQSEEQITDVHMVSDSD
GDDFEDATEFGVDDGEVFGMASSALRKSPMMPENAENEGDALLQFTAEFSSRYGDCHPVFFIGSLEAAFQEAFYVKARDRKLLAIYLHHD
ESVLTNVFCSQMLCAESIVSYLSQNFITWAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTQKTDQFPLFLIIMGKRSSNEVLNVIQGNTT
VDELMMRLMAAMEIFTAQQQEDIKDEDEREARENVKREQDEAYRLSLEADRAKREAHEREMAEQFRLEQIRKEQEEEREAIRLSLEQALP

--------------------------------------------------------------
>77042_77042_5_RPL8-FAF1_RPL8_chr8_146017377_ENST00000527914_FAF1_chr1_51061888_ENST00000396153_length(transcript)=3378nt_BP=207nt
GGAAGATAAGGCCGCTCGCTGACGCCGTGTTTCCTCTTTCGGCCGCGCTGGTGAACAGGACCCGTCGCCATGGGCCGTGTGATCCGTGGA
CAGAGGAAGGGCGCCGGGTCTGTGTTCCGCGCGCACGTGAAGCACCGTAAAGGCGCTGCGCGCCTGCGCGCCGTGGATTTCGCTGAGCGG
CACGGCTACATCAAGGGCATCGTCAAGATGTGTCTTGCTGAATCAGGGCTCTCTTATCCCTGCCATCGACTTACAGTGGGAAGAAGATCT
TCACCTGCACAGACCCGGGAACAGTCGGAAGAACAAATCACCGATGTTCATATGGTTAGTGATAGCGATGGAGATGACTTTGAAGATGCT
ACAGAATTTGGGGTGGATGATGGAGAAGTATTTGGCATGGCGTCATCTGCCTTGAGAAAATCTCCAATGATGCCAGAAAACGCAGAAAAT
GAAGGAGATGCCTTATTACAATTTACAGCAGAGTTTTCTTCAAGATATGGTGATTGCCATCCTGTATTTTTTATTGGCTCATTAGAAGCT
GCTTTTCAAGAGGCCTTCTATGTGAAAGCCCGAGATAGAAAGCTTCTTGCTATCTACCTCCACCATGATGAAAGTGTGTTAACCAACGTG
TTCTGCTCACAAATGCTTTGTGCTGAATCCATTGTTTCTTATCTGAGTCAAAATTTTATAACCTGGGCTTGGGATCTGACAAAGGACTCC
AACAGAGCAAGATTTCTCACTATGTGCAATAGACACTTTGGCAGTGTTGTGGCACAAACCATTCGGACTCAAAAAACGGATCAGTTTCCG
CTTTTCCTGATTATTATGGGAAAGCGATCATCTAATGAAGTGTTGAATGTGATACAAGGGAACACAACAGTAGATGAGTTAATGATGAGA
CTCATGGCTGCAATGGAGATCTTCACAGCCCAACAACAGGAAGATATAAAGGACGAGGATGAACGTGAAGCCAGAGAAAATGTGAAGAGA
GAGCAAGATGAGGCCTATCGCCTTTCACTTGAGGCTGACAGAGCAAAGAGGGAAGCTCACGAGAGAGAGATGGCAGAACAGTTTCGTTTG
GAGCAGATTCGCAAAGAACAAGAAGAGGAACGTGAGGCCATCCGGCTGTCCTTAGAGCAAGCCCTGCCTCCTGAGCCAAAGGAAGAAAAT
GCTGAGCCTGTGAGCAAACTGCGGATCCGGACCCCCAGTGGCGAGTTCTTGGAGCGGCGTTTCCTGGCCAGCAACAAGCTCCAGATTGTC
TTTGATTTTGTAGCTTCCAAAGGATTTCCATGGGATGAGTACAAGTTACTGAGCACCTTTCCTAGGAGAGACGTAACTCAACTGGACCCA
AATAAATCATTATTGGAGGTAAAGTTGTTCCCTCAAGAAACCCTTTTCCTTGAAGCAAAAGAGTAAACACGGCCCAGCGGTGGAACCAGC
CATTCCTTGACAAGCCAGCAGCCTGCGTCAGGAGAAGGGCTCCTCGCCAACCCACCCACACGCTCGTCTCACTCAATTCAATGTCACACT
TCTGCCTCTTGCAAAATTGCTGGAAAAAGTAATAATAAATATAGCTACTTAAGATTTCCCATCCATGAGTATATATTCCCAACCCTTATT
ACAGAGAATTACAACTCTGCCACCCTCCCCTACCCCCTGCACTTCACCCTCCTTCAATGACGAATGCATTGTTCAAGTGTGAGTGATCAC
TAAATAGAATTTTTACCTCTCCAGTGCCCATCTTTTCCCCACAGTGTCTAGGACAGTTCTGTCTGTTCTGTGACACCAGGATGCTGTATA
TTTGATATATGTCTTTTTATTTTCATGACTGAATTTCTACTTCATCACCTAATTTTAAGGGGCAGAGGGAAAAAAAGTCAAATGAGACAT
TGTCGGCATGGAGATTAAACATTGTAGGAAAAAAGTATACCATTTTTGTTAGAACTTTCTGATGGCTTTACTAAGATGTCAGGTTTTGTT
TGAGGACTGAATTTGACATATATGCAAGATATTTATTTACTGCTGCTGCCTTGGGTCTCCAGGTTCTACCTAGGAGGTATTTGCTGTTCC
ATTGCAGCATAGGGAAACTGTTCAAGCACACAATGTGAATGTTGAGATCATGTGCAGAGAGGCCAGTACCAAAACTTCAGTATCTGGCCC
AATGGCAAGAGGCTACTGTTAGGTTTGCATTTGGGCAGTTAGAACCTCACAGATACCAGCTCCCAAGTTGCTAGTCCATCAGTGTAAACT
GAACACAATTCTCTCTTGCTTTCTCTCTCTCTACTCCCTCACACATTTGGACCTTGTCACTTGGTGTTTAAGCACCTTGCCTATCAACAA
AATCTGATGAGCAGCCCCATGGACTCTCCTGTAATAAGGAACTTGCTCTACTATTTTATTCTTTTAATGTTTTAGTATTTGATATTGGAC
TCAAATGAAAGGGATCTCATTCTGTGGCTGAAAAATCAGACTTCATATGTTGAAGAGAGCAAACTTGGGGACTCAACTCAGAAGACATGT
GTTGCCTGAAACCTGCATATAATAATTTTTGATTTGATTTAGTAAGTGTGGATTTTTCTTAATCTACAGATTTGGGGTTTGGGGTTTAGA
TCATGAGAACACCGTTTATACCTTCACAGCCAATGATTTATTTTTAGTCTTGAAATATTTCTCCATATCTGTTTTTGTGTCACCTGTGGG
TTTTATCCTAGGGGTTGGGATCCTGATTTTAACATTTTGTACTTGTCCAAAAAAGAGTTCAAATGCTGGGTTTGTTCCCCCAGCCTCGGC
CAAGGGGTTCTCAGAAGATTCTAACCAAAGCTGGAGATAGGTCTGCTCATTTTCCTTCTGCCCAGAAGTGGATGTTGGCCAGGAAAATTA
CACCTTGTGTCTTCTCTGATGCTCCAACCAGGGACCTCTCCAGATTACTATCTAGCACAGACTAGTGCTACATCTGCCTAGGTATGGGCT
TTCTCTGGCAGCAGGGGTCTCTCTAGGGAGGCTGAGAGACCCATGGGTCTCCCTTCAGGGGAAGTGTTCAGGGGAGTTCAAACTGAACAC
TTCTCTCCAGCTCTATTCCTATCTTCCTAATCTAATGGCTCTACAAGATAGTCATTTCCAGTGCTACAGATGCACCAGGGCACCACCTCT
TTTTTTTTCTAGGTAGACCTTGTTCTGTAGCTGCTGTGAAGAAGCTGCAGCCCTGAACTCAGGTCATACTCAGGAACAGCAGCAGGGGTG
TGGGTGGGGTTTGAGGGAAGGTACTCTGAATTCACCTTCATGTTTAACCTGTTCCATCTGACTTGGGTTTCTTCATTATATTGTTCCCTC

>77042_77042_5_RPL8-FAF1_RPL8_chr8_146017377_ENST00000527914_FAF1_chr1_51061888_ENST00000396153_length(amino acids)=448AA_BP=46
MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKMCLAESGLSYPCHRLTVGRRSSPAQTREQSEEQITDVHMVSDSD
GDDFEDATEFGVDDGEVFGMASSALRKSPMMPENAENEGDALLQFTAEFSSRYGDCHPVFFIGSLEAAFQEAFYVKARDRKLLAIYLHHD
ESVLTNVFCSQMLCAESIVSYLSQNFITWAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTQKTDQFPLFLIIMGKRSSNEVLNVIQGNTT
VDELMMRLMAAMEIFTAQQQEDIKDEDEREARENVKREQDEAYRLSLEADRAKREAHEREMAEQFRLEQIRKEQEEEREAIRLSLEQALP

--------------------------------------------------------------
>77042_77042_6_RPL8-FAF1_RPL8_chr8_146017377_ENST00000527914_FAF1_chr1_51061888_ENST00000545823_length(transcript)=1583nt_BP=207nt
GGAAGATAAGGCCGCTCGCTGACGCCGTGTTTCCTCTTTCGGCCGCGCTGGTGAACAGGACCCGTCGCCATGGGCCGTGTGATCCGTGGA
CAGAGGAAGGGCGCCGGGTCTGTGTTCCGCGCGCACGTGAAGCACCGTAAAGGCGCTGCGCGCCTGCGCGCCGTGGATTTCGCTGAGCGG
CACGGCTACATCAAGGGCATCGTCAAGATGTGTCTTGCTGAATCAGGGCTCTCTTATCCCTGCCATCGACTTACAGTGGGAAGAAGATCT
TCACCTGCACAGACCCGGGAACAGTCGGAAGAACAAATCACCGATGTTCATATGGTTAGTGATAGCGATGGAGATGACTTTGAAGATGCT
ACAGAATTTGGGGTGGATGATGGAGAAGTATTTGGCATGGCGTCATCTGCCTTGAGAAAATCTCCAATGATGCCAGAAAACGCAGAAAAT
GAAGGAGATGCCTTATTACAATTTACAGCAGAGTTTTCTTCAAGATATGGTGATTGCCATCCTGTATTTTTTATTGGCTCATTAGAAGCT
GCTTTTCAAGAGGCCTTCTATGTGAAAGCCCGAGATAGAAAGCTTCTTGCTATCTACCTCCACCATGATGAAAGTGTGTTAACCAACGTG
TTCTGCTCACAAATGCTTTGTGCTGAATCCATTGTTTCTTATCTGAGTCAAAATTTTATAACCTGGGCTTGGGATCTGACAAAGGACTCC
AACAGAGCAAGATTTCTCACTATGTGCAATAGACACTTTGGCAGTGTTGTGGCACAAACCATTCGGACTCAAAAAACGGATCAGTTTCCG
CTTTTCCTGATTATTATGGGAAAGCGATCATCTAATGAAGTGTTGAATGTGATACAAGGGAACACAACAGTAGATGAGTTAATGATGAGA
CTCATGGCTGCAATGGAGATCTTCACAGCCCAACAACAGGAAGATATAAAGGACGAGGATGAACGTGAAGCCAGAGAAAATGTGAAGAGA
GAGCAAGATGAGGCCTATCGCCTTTCACTTGAGGCTGACAGAGCAAAGAGGGAAGCTCACGAGAGAGAGATGGCAGAACAGTTTCGTTTG
GAGCAGATTCGCAAAGAACAAGAAGAGGAACGTGAGGCCATCCGGCTGTCCTTAGAGCAAGCCCTGCCTCCTGAGCCAAAGGAAGAAAAT
GCTGAGCCTGTGAGCAAACTGCGGATCCGGACCCCCAGTGGCGAGTTCTTGGAGCGGCGTTTCCTGGCCAGCAACAAGCTCCAGATTGTC
TTTGATTTTGTAGCTTCCAAAGGATTTCCATGGGATGAGTACAAGTTACTGAGCACCTTTCCTAGGAGAGACGTAACTCAACTGGACCCA
AATAAATCATTATTGGAGGTAAAGTTGTTCCCTCAAGAAACCCTTTTCCTTGAAGCAAAAGAGTAAACACGGCCCAGCGGTGGAACCAGC
CATTCCTTGACAAGCCAGCAGCCTGCGTCAGGAGAAGGGCTCCTCGCCAACCCACCCACACGCTCGTCTCACTCAATTCAATGTCACACT

>77042_77042_6_RPL8-FAF1_RPL8_chr8_146017377_ENST00000527914_FAF1_chr1_51061888_ENST00000545823_length(amino acids)=448AA_BP=46
MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKMCLAESGLSYPCHRLTVGRRSSPAQTREQSEEQITDVHMVSDSD
GDDFEDATEFGVDDGEVFGMASSALRKSPMMPENAENEGDALLQFTAEFSSRYGDCHPVFFIGSLEAAFQEAFYVKARDRKLLAIYLHHD
ESVLTNVFCSQMLCAESIVSYLSQNFITWAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTQKTDQFPLFLIIMGKRSSNEVLNVIQGNTT
VDELMMRLMAAMEIFTAQQQEDIKDEDEREARENVKREQDEAYRLSLEADRAKREAHEREMAEQFRLEQIRKEQEEEREAIRLSLEQALP

--------------------------------------------------------------
>77042_77042_7_RPL8-FAF1_RPL8_chr8_146017377_ENST00000528957_FAF1_chr1_51061888_ENST00000371778_length(transcript)=1972nt_BP=360nt
CGGCCTTGCGGCATGGGCAGTATCCGCCGCCATCCTCTTCCGTGAGGCGCGCTGAGACCCGGACCGGCCCTCCTGAGAGGATGCCGGTGC
GGGCGCCCGCGGAGAGGGTAGGGAGTGGTGGGCGCGGCGGCCTCGGGGGCGGGGTCCCGGAAAGCCGGGCTGGCGGGGGTACCCGGGCCG
CCCGGCCGCGCTAATCGTGAGTCGCCCCCAGGACCCGTCGCCATGGGCCGTGTGATCCGTGGACAGAGGAAGGGCGCCGGGTCTGTGTTC
CGCGCGCACGTGAAGCACCGTAAAGGCGCTGCGCGCCTGCGCGCCGTGGATTTCGCTGAGCGGCACGGCTACATCAAGGGCATCGTCAAG
ATGTGTCTTGCTGAATCAGGGCTCTCTTATCCCTGCCATCGACTTACAGTGGGAAGAAGATCTTCACCTGCACAGACCCGGGAACAGTCG
GAAGAACAAATCACCGATGTTCATATGGTTAGTGATAGCGATGGAGATGACTTTGAAGATGCTACAGAATTTGGGGTGGATGATGGAGAA
GTATTTGGCATGGCGTCATCTGCCTTGAGAAAATCTCCAATGATGCCAGAAAACGCAGAAAATGAAGGAGATGCCTTATTACAATTTACA
GCAGAGTTTTCTTCAAGATATGGTGATTGCCATCCTGTATTTTTTATTGGCTCATTAGAAGCTGCTTTTCAAGAGGCCTTCTATGTGAAA
GCCCGAGATAGAAAGCTTCTTGCTATCTACCTCCACCATGATGAAAGTGTGTTAACCAACGTGTTCTGCTCACAAATGCTTTGTGCTGAA
TCCATTGTTTCTTATCTGAGTCAAAATTTTATAACCTGGGCTTGGGATCTGACAAAGGACTCCAACAGAGCAAGATTTCTCACTATGTGC
AATAGACACTTTGGCAGTGTTGTGGCACAAACCATTCGGACTCAAAAAACGGATCAGTTTCCGCTTTTCCTGATTATTATGGGAAAGCGA
TCATCTAATGAAGTGTTGAATGTGATACAAGGGAACACAACAGTAGATGAGTTAATGATGAGACTCATGGCTGCAATGGAGATCTTCACA
GCCCAACAACAGGAAGATATAAAGGACGAGGATGAACGTGAAGCCAGAGAAAATGTGAAGAGAGAGCAAGATGAGGCCTATCGCCTTTCA
CTTGAGGCTGACAGAGCAAAGAGGGAAGCTCACGAGAGAGAGATGGCAGAACAGTTTCGTTTGGAGCAGATTCGCAAAGAACAAGAAGAG
GAACGTGAGGCCATCCGGCTGTCCTTAGAGCAAGCCCTGCCTCCTGAGCCAAAGGAAGAAAATGCTGAGCCTGTGAGCAAACTGCGGATC
CGGACCCCCAGTGGCGAGTTCTTGGAGCGGCGTTTCCTGGCCAGCAACAAGCTCCAGATTGTCTTTGATTTTGTAGCTTCCAAAGGATTT
CCATGGGATGAGTACAAGTTACTGAGCACCTTTCCTAGGAGAGACGTAACTCAACTGGACCCAAATAAATCATTATTGGAGGTAAAGTTG
TTCCCTCAAGAAACCCTTTTCCTTGAAGCAAAAGAGTAAACACGGCCCAGCGGTGGAACCAGCCATTCCTTGACAAGCCAGCAGCCTGCG
TCAGGAGAAGGGCTCCTCGCCAACCCACCCACACGCTCGTCTCACTCAATTCAATGTCACACTTCTGCCTCTTGCAAAATTGCTGGAAAA
AGTAATAATAAATATAGCTACTTAAGATTTCCCATCCATGAGTATATATTCCCAACCCTTATTACAGAGAATTACAACTCTGCCACCCTC
CCCTACCCCCTGCACTTCACCCTCCTTCAATGACGAATGCATTGTTCAAGTGTGAGTGATCACTAAATAGAATTTTTACCTCTCCAGTGC

>77042_77042_7_RPL8-FAF1_RPL8_chr8_146017377_ENST00000528957_FAF1_chr1_51061888_ENST00000371778_length(amino acids)=469AA_BP=67
MAGVPGPPGRANRESPPGPVAMGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKMCLAESGLSYPCHRLTVGRRSSP
AQTREQSEEQITDVHMVSDSDGDDFEDATEFGVDDGEVFGMASSALRKSPMMPENAENEGDALLQFTAEFSSRYGDCHPVFFIGSLEAAF
QEAFYVKARDRKLLAIYLHHDESVLTNVFCSQMLCAESIVSYLSQNFITWAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTQKTDQFPLF
LIIMGKRSSNEVLNVIQGNTTVDELMMRLMAAMEIFTAQQQEDIKDEDEREARENVKREQDEAYRLSLEADRAKREAHEREMAEQFRLEQ
IRKEQEEEREAIRLSLEQALPPEPKEENAEPVSKLRIRTPSGEFLERRFLASNKLQIVFDFVASKGFPWDEYKLLSTFPRRDVTQLDPNK

--------------------------------------------------------------
>77042_77042_8_RPL8-FAF1_RPL8_chr8_146017377_ENST00000528957_FAF1_chr1_51061888_ENST00000396153_length(transcript)=3531nt_BP=360nt
CGGCCTTGCGGCATGGGCAGTATCCGCCGCCATCCTCTTCCGTGAGGCGCGCTGAGACCCGGACCGGCCCTCCTGAGAGGATGCCGGTGC
GGGCGCCCGCGGAGAGGGTAGGGAGTGGTGGGCGCGGCGGCCTCGGGGGCGGGGTCCCGGAAAGCCGGGCTGGCGGGGGTACCCGGGCCG
CCCGGCCGCGCTAATCGTGAGTCGCCCCCAGGACCCGTCGCCATGGGCCGTGTGATCCGTGGACAGAGGAAGGGCGCCGGGTCTGTGTTC
CGCGCGCACGTGAAGCACCGTAAAGGCGCTGCGCGCCTGCGCGCCGTGGATTTCGCTGAGCGGCACGGCTACATCAAGGGCATCGTCAAG
ATGTGTCTTGCTGAATCAGGGCTCTCTTATCCCTGCCATCGACTTACAGTGGGAAGAAGATCTTCACCTGCACAGACCCGGGAACAGTCG
GAAGAACAAATCACCGATGTTCATATGGTTAGTGATAGCGATGGAGATGACTTTGAAGATGCTACAGAATTTGGGGTGGATGATGGAGAA
GTATTTGGCATGGCGTCATCTGCCTTGAGAAAATCTCCAATGATGCCAGAAAACGCAGAAAATGAAGGAGATGCCTTATTACAATTTACA
GCAGAGTTTTCTTCAAGATATGGTGATTGCCATCCTGTATTTTTTATTGGCTCATTAGAAGCTGCTTTTCAAGAGGCCTTCTATGTGAAA
GCCCGAGATAGAAAGCTTCTTGCTATCTACCTCCACCATGATGAAAGTGTGTTAACCAACGTGTTCTGCTCACAAATGCTTTGTGCTGAA
TCCATTGTTTCTTATCTGAGTCAAAATTTTATAACCTGGGCTTGGGATCTGACAAAGGACTCCAACAGAGCAAGATTTCTCACTATGTGC
AATAGACACTTTGGCAGTGTTGTGGCACAAACCATTCGGACTCAAAAAACGGATCAGTTTCCGCTTTTCCTGATTATTATGGGAAAGCGA
TCATCTAATGAAGTGTTGAATGTGATACAAGGGAACACAACAGTAGATGAGTTAATGATGAGACTCATGGCTGCAATGGAGATCTTCACA
GCCCAACAACAGGAAGATATAAAGGACGAGGATGAACGTGAAGCCAGAGAAAATGTGAAGAGAGAGCAAGATGAGGCCTATCGCCTTTCA
CTTGAGGCTGACAGAGCAAAGAGGGAAGCTCACGAGAGAGAGATGGCAGAACAGTTTCGTTTGGAGCAGATTCGCAAAGAACAAGAAGAG
GAACGTGAGGCCATCCGGCTGTCCTTAGAGCAAGCCCTGCCTCCTGAGCCAAAGGAAGAAAATGCTGAGCCTGTGAGCAAACTGCGGATC
CGGACCCCCAGTGGCGAGTTCTTGGAGCGGCGTTTCCTGGCCAGCAACAAGCTCCAGATTGTCTTTGATTTTGTAGCTTCCAAAGGATTT
CCATGGGATGAGTACAAGTTACTGAGCACCTTTCCTAGGAGAGACGTAACTCAACTGGACCCAAATAAATCATTATTGGAGGTAAAGTTG
TTCCCTCAAGAAACCCTTTTCCTTGAAGCAAAAGAGTAAACACGGCCCAGCGGTGGAACCAGCCATTCCTTGACAAGCCAGCAGCCTGCG
TCAGGAGAAGGGCTCCTCGCCAACCCACCCACACGCTCGTCTCACTCAATTCAATGTCACACTTCTGCCTCTTGCAAAATTGCTGGAAAA
AGTAATAATAAATATAGCTACTTAAGATTTCCCATCCATGAGTATATATTCCCAACCCTTATTACAGAGAATTACAACTCTGCCACCCTC
CCCTACCCCCTGCACTTCACCCTCCTTCAATGACGAATGCATTGTTCAAGTGTGAGTGATCACTAAATAGAATTTTTACCTCTCCAGTGC
CCATCTTTTCCCCACAGTGTCTAGGACAGTTCTGTCTGTTCTGTGACACCAGGATGCTGTATATTTGATATATGTCTTTTTATTTTCATG
ACTGAATTTCTACTTCATCACCTAATTTTAAGGGGCAGAGGGAAAAAAAGTCAAATGAGACATTGTCGGCATGGAGATTAAACATTGTAG
GAAAAAAGTATACCATTTTTGTTAGAACTTTCTGATGGCTTTACTAAGATGTCAGGTTTTGTTTGAGGACTGAATTTGACATATATGCAA
GATATTTATTTACTGCTGCTGCCTTGGGTCTCCAGGTTCTACCTAGGAGGTATTTGCTGTTCCATTGCAGCATAGGGAAACTGTTCAAGC
ACACAATGTGAATGTTGAGATCATGTGCAGAGAGGCCAGTACCAAAACTTCAGTATCTGGCCCAATGGCAAGAGGCTACTGTTAGGTTTG
CATTTGGGCAGTTAGAACCTCACAGATACCAGCTCCCAAGTTGCTAGTCCATCAGTGTAAACTGAACACAATTCTCTCTTGCTTTCTCTC
TCTCTACTCCCTCACACATTTGGACCTTGTCACTTGGTGTTTAAGCACCTTGCCTATCAACAAAATCTGATGAGCAGCCCCATGGACTCT
CCTGTAATAAGGAACTTGCTCTACTATTTTATTCTTTTAATGTTTTAGTATTTGATATTGGACTCAAATGAAAGGGATCTCATTCTGTGG
CTGAAAAATCAGACTTCATATGTTGAAGAGAGCAAACTTGGGGACTCAACTCAGAAGACATGTGTTGCCTGAAACCTGCATATAATAATT
TTTGATTTGATTTAGTAAGTGTGGATTTTTCTTAATCTACAGATTTGGGGTTTGGGGTTTAGATCATGAGAACACCGTTTATACCTTCAC
AGCCAATGATTTATTTTTAGTCTTGAAATATTTCTCCATATCTGTTTTTGTGTCACCTGTGGGTTTTATCCTAGGGGTTGGGATCCTGAT
TTTAACATTTTGTACTTGTCCAAAAAAGAGTTCAAATGCTGGGTTTGTTCCCCCAGCCTCGGCCAAGGGGTTCTCAGAAGATTCTAACCA
AAGCTGGAGATAGGTCTGCTCATTTTCCTTCTGCCCAGAAGTGGATGTTGGCCAGGAAAATTACACCTTGTGTCTTCTCTGATGCTCCAA
CCAGGGACCTCTCCAGATTACTATCTAGCACAGACTAGTGCTACATCTGCCTAGGTATGGGCTTTCTCTGGCAGCAGGGGTCTCTCTAGG
GAGGCTGAGAGACCCATGGGTCTCCCTTCAGGGGAAGTGTTCAGGGGAGTTCAAACTGAACACTTCTCTCCAGCTCTATTCCTATCTTCC
TAATCTAATGGCTCTACAAGATAGTCATTTCCAGTGCTACAGATGCACCAGGGCACCACCTCTTTTTTTTTCTAGGTAGACCTTGTTCTG
TAGCTGCTGTGAAGAAGCTGCAGCCCTGAACTCAGGTCATACTCAGGAACAGCAGCAGGGGTGTGGGTGGGGTTTGAGGGAAGGTACTCT
GAATTCACCTTCATGTTTAACCTGTTCCATCTGACTTGGGTTTCTTCATTATATTGTTCCCTCCCACTCACCTTCACTTCTGTATTACAA

>77042_77042_8_RPL8-FAF1_RPL8_chr8_146017377_ENST00000528957_FAF1_chr1_51061888_ENST00000396153_length(amino acids)=469AA_BP=67
MAGVPGPPGRANRESPPGPVAMGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKMCLAESGLSYPCHRLTVGRRSSP
AQTREQSEEQITDVHMVSDSDGDDFEDATEFGVDDGEVFGMASSALRKSPMMPENAENEGDALLQFTAEFSSRYGDCHPVFFIGSLEAAF
QEAFYVKARDRKLLAIYLHHDESVLTNVFCSQMLCAESIVSYLSQNFITWAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTQKTDQFPLF
LIIMGKRSSNEVLNVIQGNTTVDELMMRLMAAMEIFTAQQQEDIKDEDEREARENVKREQDEAYRLSLEADRAKREAHEREMAEQFRLEQ
IRKEQEEEREAIRLSLEQALPPEPKEENAEPVSKLRIRTPSGEFLERRFLASNKLQIVFDFVASKGFPWDEYKLLSTFPRRDVTQLDPNK

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>77042_77042_9_RPL8-FAF1_RPL8_chr8_146017377_ENST00000528957_FAF1_chr1_51061888_ENST00000545823_length(transcript)=1736nt_BP=360nt
CGGCCTTGCGGCATGGGCAGTATCCGCCGCCATCCTCTTCCGTGAGGCGCGCTGAGACCCGGACCGGCCCTCCTGAGAGGATGCCGGTGC
GGGCGCCCGCGGAGAGGGTAGGGAGTGGTGGGCGCGGCGGCCTCGGGGGCGGGGTCCCGGAAAGCCGGGCTGGCGGGGGTACCCGGGCCG
CCCGGCCGCGCTAATCGTGAGTCGCCCCCAGGACCCGTCGCCATGGGCCGTGTGATCCGTGGACAGAGGAAGGGCGCCGGGTCTGTGTTC
CGCGCGCACGTGAAGCACCGTAAAGGCGCTGCGCGCCTGCGCGCCGTGGATTTCGCTGAGCGGCACGGCTACATCAAGGGCATCGTCAAG
ATGTGTCTTGCTGAATCAGGGCTCTCTTATCCCTGCCATCGACTTACAGTGGGAAGAAGATCTTCACCTGCACAGACCCGGGAACAGTCG
GAAGAACAAATCACCGATGTTCATATGGTTAGTGATAGCGATGGAGATGACTTTGAAGATGCTACAGAATTTGGGGTGGATGATGGAGAA
GTATTTGGCATGGCGTCATCTGCCTTGAGAAAATCTCCAATGATGCCAGAAAACGCAGAAAATGAAGGAGATGCCTTATTACAATTTACA
GCAGAGTTTTCTTCAAGATATGGTGATTGCCATCCTGTATTTTTTATTGGCTCATTAGAAGCTGCTTTTCAAGAGGCCTTCTATGTGAAA
GCCCGAGATAGAAAGCTTCTTGCTATCTACCTCCACCATGATGAAAGTGTGTTAACCAACGTGTTCTGCTCACAAATGCTTTGTGCTGAA
TCCATTGTTTCTTATCTGAGTCAAAATTTTATAACCTGGGCTTGGGATCTGACAAAGGACTCCAACAGAGCAAGATTTCTCACTATGTGC
AATAGACACTTTGGCAGTGTTGTGGCACAAACCATTCGGACTCAAAAAACGGATCAGTTTCCGCTTTTCCTGATTATTATGGGAAAGCGA
TCATCTAATGAAGTGTTGAATGTGATACAAGGGAACACAACAGTAGATGAGTTAATGATGAGACTCATGGCTGCAATGGAGATCTTCACA
GCCCAACAACAGGAAGATATAAAGGACGAGGATGAACGTGAAGCCAGAGAAAATGTGAAGAGAGAGCAAGATGAGGCCTATCGCCTTTCA
CTTGAGGCTGACAGAGCAAAGAGGGAAGCTCACGAGAGAGAGATGGCAGAACAGTTTCGTTTGGAGCAGATTCGCAAAGAACAAGAAGAG
GAACGTGAGGCCATCCGGCTGTCCTTAGAGCAAGCCCTGCCTCCTGAGCCAAAGGAAGAAAATGCTGAGCCTGTGAGCAAACTGCGGATC
CGGACCCCCAGTGGCGAGTTCTTGGAGCGGCGTTTCCTGGCCAGCAACAAGCTCCAGATTGTCTTTGATTTTGTAGCTTCCAAAGGATTT
CCATGGGATGAGTACAAGTTACTGAGCACCTTTCCTAGGAGAGACGTAACTCAACTGGACCCAAATAAATCATTATTGGAGGTAAAGTTG
TTCCCTCAAGAAACCCTTTTCCTTGAAGCAAAAGAGTAAACACGGCCCAGCGGTGGAACCAGCCATTCCTTGACAAGCCAGCAGCCTGCG
TCAGGAGAAGGGCTCCTCGCCAACCCACCCACACGCTCGTCTCACTCAATTCAATGTCACACTTCTGCCTCTTGCAAAATTGCTGGAAAA

>77042_77042_9_RPL8-FAF1_RPL8_chr8_146017377_ENST00000528957_FAF1_chr1_51061888_ENST00000545823_length(amino acids)=469AA_BP=67
MAGVPGPPGRANRESPPGPVAMGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKMCLAESGLSYPCHRLTVGRRSSP
AQTREQSEEQITDVHMVSDSDGDDFEDATEFGVDDGEVFGMASSALRKSPMMPENAENEGDALLQFTAEFSSRYGDCHPVFFIGSLEAAF
QEAFYVKARDRKLLAIYLHHDESVLTNVFCSQMLCAESIVSYLSQNFITWAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTQKTDQFPLF
LIIMGKRSSNEVLNVIQGNTTVDELMMRLMAAMEIFTAQQQEDIKDEDEREARENVKREQDEAYRLSLEADRAKREAHEREMAEQFRLEQ
IRKEQEEEREAIRLSLEQALPPEPKEENAEPVSKLRIRTPSGEFLERRFLASNKLQIVFDFVASKGFPWDEYKLLSTFPRRDVTQLDPNK

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Fusion Gene PPI Analysis for RPL8-FAF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RPL8-FAF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RPL8-FAF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource