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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:RPL8-GLG1 (FusionGDB2 ID:77044)

Fusion Gene Summary for RPL8-GLG1

Fusion gene summary

Fusion gene information	Fusion gene name: RPL8-GLG1
	Fusion gene ID: 77044
		Hgene	Tgene
	Gene symbol	RPL8	GLG1
	Gene ID	6132	2734
	Gene name	ribosomal protein L8	golgi glycoprotein 1
	Synonyms	L8	CFR-1\|ESL-1\|MG-160\|MG160
	Cytomap	8q24.3	16q23.1
	Type of gene	protein-coding	protein-coding
	Description	60S ribosomal protein L8large ribosomal subunit protein uL2	Golgi apparatus protein 1E-selectin ligand 1cysteine-rich fibroblast growth factor receptorgolgi sialoglycoprotein MG-160
	Modification date	20200327	20200313
	UniProtAcc	.	Q92896
	Ensembl transtripts involved in fusion gene	ENST00000262584, ENST00000394920, ENST00000527914, ENST00000529163, ENST00000528957,	ENST00000447066, ENST00000205061, ENST00000422840,
Fusion gene scores	* DoF score	36 X 18 X 15=9720	13 X 13 X 4=676
	# samples	37	12
	** MAII score	log2(37/9720*10)=-4.71535913797683 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/676*10)=-2.49398884067367 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RPL8 [Title/Abstract] AND GLG1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RPL8(146015154)-GLG1(74566051), # samples:1
Anticipated loss of major functional domain due to fusion event.	RPL8-GLG1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. RPL8-GLG1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPL8	GO:0002181	cytoplasmic translation	25957688

Fusion gene breakpoints across RPL8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GLG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-EE-A2MT-06A	RPL8	chr8	146015154	-	GLG1	chr16	74566051	-

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Fusion Gene ORF analysis for RPL8-GLG1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000262584	ENST00000447066	RPL8	chr8	146015154	-	GLG1	chr16	74566051	-
5CDS-intron	ENST00000394920	ENST00000447066	RPL8	chr8	146015154	-	GLG1	chr16	74566051	-
5CDS-intron	ENST00000527914	ENST00000447066	RPL8	chr8	146015154	-	GLG1	chr16	74566051	-
5CDS-intron	ENST00000529163	ENST00000447066	RPL8	chr8	146015154	-	GLG1	chr16	74566051	-
Frame-shift	ENST00000262584	ENST00000205061	RPL8	chr8	146015154	-	GLG1	chr16	74566051	-
Frame-shift	ENST00000262584	ENST00000422840	RPL8	chr8	146015154	-	GLG1	chr16	74566051	-
Frame-shift	ENST00000527914	ENST00000205061	RPL8	chr8	146015154	-	GLG1	chr16	74566051	-
Frame-shift	ENST00000527914	ENST00000422840	RPL8	chr8	146015154	-	GLG1	chr16	74566051	-
Frame-shift	ENST00000529163	ENST00000205061	RPL8	chr8	146015154	-	GLG1	chr16	74566051	-
Frame-shift	ENST00000529163	ENST00000422840	RPL8	chr8	146015154	-	GLG1	chr16	74566051	-
In-frame	ENST00000394920	ENST00000205061	RPL8	chr8	146015154	-	GLG1	chr16	74566051	-
In-frame	ENST00000394920	ENST00000422840	RPL8	chr8	146015154	-	GLG1	chr16	74566051	-
intron-3CDS	ENST00000528957	ENST00000205061	RPL8	chr8	146015154	-	GLG1	chr16	74566051	-
intron-3CDS	ENST00000528957	ENST00000422840	RPL8	chr8	146015154	-	GLG1	chr16	74566051	-
intron-intron	ENST00000528957	ENST00000447066	RPL8	chr8	146015154	-	GLG1	chr16	74566051	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000394920	RPL8	chr8	146015154	-	ENST00000205061	GLG1	chr16	74566051	-	4237	965	737	4138	1133
ENST00000394920	RPL8	chr8	146015154	-	ENST00000422840	GLG1	chr16	74566051	-	5275	965	737	4066	1109

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000394920	ENST00000205061	RPL8	chr8	146015154	-	GLG1	chr16	74566051	-	0.000954731	0.9990452
ENST00000394920	ENST00000422840	RPL8	chr8	146015154	-	GLG1	chr16	74566051	-	0.001191821	0.99880815

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Fusion Genomic Features for RPL8-GLG1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RPL8-GLG1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:146015154/chr16:74566051)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	GLG1 Q92896
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils). {ECO:0000269\|PubMed:8985126}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000447066

54_57

1193.0

Compositional bias

Note=Poly-Gly

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000447066

71_86

1193.0

Compositional bias

Note=Poly-Gln

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000205061

1041_1101

146

1204.0

Repeat

Note=Cys-rich GLG1 16

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000205061

150_212

146

1204.0

Repeat

Note=Cys-rich GLG1 2

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000205061

215_278

146

1204.0

Repeat

Note=Cys-rich GLG1 3

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000205061

286_346

146

1204.0

Repeat

Note=Cys-rich GLG1 4

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000205061

347_413

146

1204.0

Repeat

Note=Cys-rich GLG1 5

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000205061

414_473

146

1204.0

Repeat

Note=Cys-rich GLG1 6

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000205061

475_537

146

1204.0

Repeat

Note=Cys-rich GLG1 7

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000205061

538_604

146

1204.0

Repeat

Note=Cys-rich GLG1 8

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000205061

609_668

146

1204.0

Repeat

Note=Cys-rich GLG1 9

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000205061

670_728

146

1204.0

Repeat

Note=Cys-rich GLG1 10

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000205061

729_788

146

1204.0

Repeat

Note=Cys-rich GLG1 11

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000205061

796_856

146

1204.0

Repeat

Note=Cys-rich GLG1 12

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000205061

858_911

146

1204.0

Repeat

Note=Cys-rich GLG1 13

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000205061

912_979

146

1204.0

Repeat

Note=Cys-rich GLG1 14

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000205061

980_1035

146

1204.0

Repeat

Note=Cys-rich GLG1 15

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000422840

1041_1101

146

1180.0

Repeat

Note=Cys-rich GLG1 16

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000422840

150_212

146

1180.0

Repeat

Note=Cys-rich GLG1 2

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000422840

215_278

146

1180.0

Repeat

Note=Cys-rich GLG1 3

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000422840

286_346

146

1180.0

Repeat

Note=Cys-rich GLG1 4

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000422840

347_413

146

1180.0

Repeat

Note=Cys-rich GLG1 5

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000422840

414_473

146

1180.0

Repeat

Note=Cys-rich GLG1 6

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000422840

475_537

146

1180.0

Repeat

Note=Cys-rich GLG1 7

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000422840

538_604

146

1180.0

Repeat

Note=Cys-rich GLG1 8

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000422840

609_668

146

1180.0

Repeat

Note=Cys-rich GLG1 9

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000422840

670_728

146

1180.0

Repeat

Note=Cys-rich GLG1 10

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000422840

729_788

146

1180.0

Repeat

Note=Cys-rich GLG1 11

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000422840

796_856

146

1180.0

Repeat

Note=Cys-rich GLG1 12

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000422840

858_911

146

1180.0

Repeat

Note=Cys-rich GLG1 13

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000422840

912_979

146

1180.0

Repeat

Note=Cys-rich GLG1 14

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000422840

980_1035

146

1180.0

Repeat

Note=Cys-rich GLG1 15

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000447066

1041_1101

1193.0

Repeat

Note=Cys-rich GLG1 16

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000447066

116_149

1193.0

Repeat

Note=Cys-rich GLG1 1

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000447066

150_212

1193.0

Repeat

Note=Cys-rich GLG1 2

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000447066

215_278

1193.0

Repeat

Note=Cys-rich GLG1 3

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000447066

286_346

1193.0

Repeat

Note=Cys-rich GLG1 4

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000447066

347_413

1193.0

Repeat

Note=Cys-rich GLG1 5

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000447066

414_473

1193.0

Repeat

Note=Cys-rich GLG1 6

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000447066

475_537

1193.0

Repeat

Note=Cys-rich GLG1 7

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000447066

538_604

1193.0

Repeat

Note=Cys-rich GLG1 8

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000447066

609_668

1193.0

Repeat

Note=Cys-rich GLG1 9

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000447066

670_728

1193.0

Repeat

Note=Cys-rich GLG1 10

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000447066

729_788

1193.0

Repeat

Note=Cys-rich GLG1 11

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000447066

796_856

1193.0

Repeat

Note=Cys-rich GLG1 12

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000447066

858_911

1193.0

Repeat

Note=Cys-rich GLG1 13

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000447066

912_979

1193.0

Repeat

Note=Cys-rich GLG1 14

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000447066

980_1035

1193.0

Repeat

Note=Cys-rich GLG1 15

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000205061

1167_1179

146

1204.0

Topological domain

Cytoplasmic

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000422840

1167_1179

146

1180.0

Topological domain

Cytoplasmic

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000447066

1167_1179

1193.0

Topological domain

Cytoplasmic

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000447066

30_1145

1193.0

Topological domain

Extracellular

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000205061

1146_1166

146

1204.0

Transmembrane

Helical

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000422840

1146_1166

146

1180.0

Transmembrane

Helical

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000447066

1146_1166

1193.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000205061

54_57

146

1204.0

Compositional bias

Note=Poly-Gly

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000205061

71_86

146

1204.0

Compositional bias

Note=Poly-Gln

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000422840

54_57

146

1180.0

Compositional bias

Note=Poly-Gly

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000422840

71_86

146

1180.0

Compositional bias

Note=Poly-Gln

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000205061

116_149

146

1204.0

Repeat

Note=Cys-rich GLG1 1

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000422840

116_149

146

1180.0

Repeat

Note=Cys-rich GLG1 1

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000205061

30_1145

146

1204.0

Topological domain

Extracellular

Tgene

GLG1

chr8:146015154

chr16:74566051

ENST00000422840

30_1145

146

1180.0

Topological domain

Extracellular

Top

Fusion Gene Sequence for RPL8-GLG1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>77044_77044_1_RPL8-GLG1_RPL8_chr8_146015154_ENST00000394920_GLG1_chr16_74566051_ENST00000205061_length(transcript)=4237nt_BP=965nt
TCTTTCGGCCGCGCTGGTGAACAGGTAGGTCATCCTTGCGGCCTTGCGGCATGGGCAGTATCCGCCGCCATCCTCTTCCGTGAGGCGCGC
TGAGACCCGGACCGGCCCTCCTGAGAGGATGCCGGTGCGGGCGCCCGCGGAGAGGGACCCGTCGCCATGGGCCGTGTGATCCGTGGACAG
AGGAAGGGCGCCGGGTCTGTGTTCCGCGCGCACGTGAAGCACCGTAAAGGCGCTGCGCGCCTGCGCGCCGTGGATTTCGCTGAGCGGCAC
GGCTACATCAAGGGCATCGTCAAGGACATCATCCACGACCCGGGCCGCGGCGCGCCCCTCGCCAAGGTGGTCTTCCGGGATCCGTATCGG
TTTAAGAAGCGGACGGAGCTGTTCATTGCCGCCGAGGGCATTCACACGGGCCAGTTTGTGTATTGCGGCAAGAAGGCCCAGCTCAACATT
GGCAATGTGCTCCCTGTGGGCACCATGCCTGAGGGTACAATCGTGTGCTGCCTGGAGGAGAAGCCTGGAGACCGTGGCAAGCTGGCCCGG
GCATCAGGGAACTATGCCACCGTTATCTCCCACAACCCTGAGACCAAGAAGACCCGTGTGAAGCTGCCCTCCGGCTCCAAGAAGGTTATC
TCCTCAGCCAACAGAGCTGTGGTTGGTGTGGTGGCTGGAGGTGGCCGAATTGACAAACCCATCTTGAAGGCTGGCCGGGCGTACCACAAA
TATAAGGCAAAGAGGAACTGCTGGCCACGAGTACGGGGTGTGGCCATGAATCCTGTGGAGCATCCTTTTGGAGGTGGCAACCACCAGCAC
ATCGGCAAGCCCTCCACCATCCGCAGAGATGCCCCTGCTGGCCGCAAAGTGGGTCTCATTGCTGCCCGCCGGACTGGACGTCTCCGGGGA
ACCAAGACTGTGCAGGAGAAAGAGAACTAGTGCTGAGGGCCTCAATAAAGTTTGTGTTTATGCCACCTGAAAATGAAATTTCTTCAGACT
GCAATCATTTGTTGTGGAATTATAAGCTGAACCTAACTACAGATCCCAAATTTGAATCTGTGGCCAGAGAGGTTTGCAAATCTACTATAA
CAGAGATTAAAGAATGTGCTGATGAACCGGTTGGAAAAGGTTACATGGTTTCCTGCTTGGTGGATCACCGAGGCAACATCACTGAGTATC
AGTGTCACCAGTACATTACCAAGATGACGGCCATCATTTTTAGTGATTACCGTTTAATCTGTGGCTTCATGGATGACTGCAAAAATGACA
TCAACATTCTGAAATGTGGCAGTATTCGGCTTGGAGAAAAGGATGCACATTCACAAGGTGAGGTGGTATCATGCTTGGAGAAAGGCCTGG
TGAAAGAAGCAGAAGAAAGAGAACCCAAGATTCAAGTTTCTGAACTCTGCAAGAAAGCCATTCTCCGGGTGGCTGAGCTGTCATCGGATG
ACTTTCACTTAGACCGGCATTTATATTTTGCTTGCCGAGATGATCGGGAGCGTTTTTGTGAAAATACACAAGCTGGTGAGGGCAGAGTGT
ATAAGTGCCTCTTTAACCATAAATTTGAAGAATCCATGAGTGAAAAGTGTCGAGAAGCACTTACAACCCGCCAAAAGCTGATTGCCCAGG
ATTATAAAGTCAGTTATTCATTGGCCAAATCCTGTAAAAGTGACTTGAAGAAATACCGGTGCAATGTGGAAAACCTTCCGCGATCGCGTG
AAGCCAGGCTCTCCTACTTGTTAATGTGCCTGGAGTCAGCTGTACACAGAGGGCGACAAGTCAGCAGTGAGTGCCAGGGGGAGATGCTGG
ATTACCGACGCATGTTGATGGAAGACTTTTCTCTGAGCCCTGAGATCATCCTAAGCTGTCGGGGGGAGATTGAACACCATTGTTCCGGAT
TACATCGAAAAGGGCGGACCCTACACTGTCTGATGAAAGTAGTTCGAGGGGAGAAGGGGAACCTTGGAATGAACTGCCAGCAGGCGCTTC
AAACACTGATTCAGGAGACTGACCCTGGTGCAGATTACCGCATTGATCGAGCTTTGAATGAAGCTTGTGAATCTGTAATCCAGACAGCCT
GCAAACATATAAGATCTGGAGACCCAATGATCTTGTCGTGCCTGATGGAACATTTATACACAGAGAAGATGGTAGAAGACTGTGAACACC
GTCTCTTAGAGCTGCAGTATTTCATCTCCCGGGATTGGAAGCTGGACCCTGTCCTGTACCGCAAGTGCCAGGGAGACGCTTCTCGTCTTT
GCCACACCCACGGTTGGAATGAGACCAGTGAATTTATGCCTCAGGGAGCTGTGTTCTCTTGTTTATACAGACACGCCTACCGCACTGAGG
AACAGGGAAGGAGGCTCTCACGGGAGTGCCGAGCTGAAGTCCAAAGGATCCTACACCAGCGTGCCATGGATGTCAAGCTGGATCCTGCCC
TCCAGGATAAGTGCCTGATTGATCTGGGAAAATGGTGCAGTGAGAAAACAGAGACTGGACAGGAGCTGGAGTGCCTTCAGGACCATCTGG
ATGACTTGGTGGTGGAGTGTAGAGATATAGTTGGCAACCTCACTGAGTTAGAATCAGAGGATATTCAAATAGAAGCCTTGCTGATGAGAG
CCTGTGAGCCCATAATTCAGAACTTCTGCCACGATGTGGCAGATAACCAGATAGACTCTGGGGACCTGATGGAGTGTCTGATACAGAACA
AACACCAGAAGGACATGAACGAGAAGTGTGCCATCGGAGTTACCCACTTCCAGCTGGTGCAGATGAAGGATTTTCGGTTTTCTTACAAGT
TTAAAATGGCCTGCAAGGAGGACGTGTTGAAGCTTTGCCCAAACATAAAAAAGAAGGTGGACGTGGTGATCTGCCTGAGCACGACCGTGC
GCAATGACACTCTGCAGGAAGCCAAGGAGCACAGGGTGTCCCTGAAGTGCCGCAGGCAGCTCCGTGTGGAGGAGCTGGAGATGACGGAGG
ACATCCGCTTGGAGCCAGATCTATACGAAGCCTGCAAGAGTGACATCAAAAACTTCTGTTCCGCTGTGCAATATGGCAACGCTCAGATTA
TCGAATGTCTGAAAGAAAACAAGAAGCAGCTAAGCACCCGCTGCCACCAAAAAGTATTTAAGCTGCAGGAGACAGAGATGATGGACCCAG
AGCTAGACTACACCCTCATGAGGGTCTGCAAGCAGATGATAAAGAGGTTCTGTCCGGAAGCAGATTCTAAAACCATGTTGCAGTGCTTGA
AGCAAAATAAAAACAGTGAATTGATGGATCCCAAATGCAAACAGATGATAACCAAGCGCCAGATCACCCAGAACACAGATTACCGCTTAA
ACCCCATGTTAAGAAAAGCCTGTAAAGCTGACATTCCTAAATTCTGTCACGGTATCCTGACTAAGGCCAAGGATGATTCAGAATTAGAAG
GACAAGTCATCTCTTGCCTGAAGCTGAGATATGCTGACCAGCGCCTGTCTTCAGACTGTGAAGACCAGATCCGAATCATTATCCAGGAGT
CCGCCCTGGACTACCGCCTGGATCCTCAGCTCCAGCTGCACTGCTCAGACGAGATCTCCAGTCTATGTGCTGAAGAAGCAGCAGCCCAAG
AGCAGACAGGTCAGGTGGAGGAGTGCCTCAAGGTCAACCTGCTCAAGATCAAAACAGAATTGTGTAAAAAGGAAGTGCTAAACATGCTGA
AGGAAAGCAAAGCAGACATCTTTGTTGACCCGGTACTTCATACTGCTTGTGCCCTGGACATTAAACACCACTGCGCAGCCATCACCCCTG
GCCGCGGGCGTCAAATGTCCTGTCTCATGGAAGCACTGGAGGATAAGCGGGTGAGGTTACAGCCCGAGTGCAAAAAGCGCCTCAATGACC
GGATTGAGATGTGGAGTTACGCAGCAAAGGTGGCCCCAGCAGATGGCTTCTCTGATCTTGCCATGCAAGTAATGACGTCTCCATCTAAGA
ACTACATTCTCTCTGTGATCAGTGGGAGCATCTGTATATTGTTCCTGATTGGCCTGATGTGTGGACGGATCACCAAGCGAGTGACACGAG
AGCTCAAGGACAGGCTACAATACAGGTCAGAGACAATGGCTTATAAAGGTTTAGTGTGGTCTCAGGATGTGACAGGCAGTCCAGCCTGAC
CTTTCTGCACACTCCAGACAAACTTCCCAGACAAGCTCCTTTGTGCCTCTACGTGGAGAGGGTGTGGAAAGTTATCACATTAAAAGATGG

>77044_77044_1_RPL8-GLG1_RPL8_chr8_146015154_ENST00000394920_GLG1_chr16_74566051_ENST00000205061_length(amino acids)=1133AA_BP=76
MLATSTGCGHESCGASFWRWQPPAHRQALHHPQRCPCWPQSGSHCCPPDWTSPGNQDCAGERELVLRASIKFVFMPPENEISSDCNHLLW
NYKLNLTTDPKFESVAREVCKSTITEIKECADEPVGKGYMVSCLVDHRGNITEYQCHQYITKMTAIIFSDYRLICGFMDDCKNDINILKC
GSIRLGEKDAHSQGEVVSCLEKGLVKEAEEREPKIQVSELCKKAILRVAELSSDDFHLDRHLYFACRDDRERFCENTQAGEGRVYKCLFN
HKFEESMSEKCREALTTRQKLIAQDYKVSYSLAKSCKSDLKKYRCNVENLPRSREARLSYLLMCLESAVHRGRQVSSECQGEMLDYRRML
MEDFSLSPEIILSCRGEIEHHCSGLHRKGRTLHCLMKVVRGEKGNLGMNCQQALQTLIQETDPGADYRIDRALNEACESVIQTACKHIRS
GDPMILSCLMEHLYTEKMVEDCEHRLLELQYFISRDWKLDPVLYRKCQGDASRLCHTHGWNETSEFMPQGAVFSCLYRHAYRTEEQGRRL
SRECRAEVQRILHQRAMDVKLDPALQDKCLIDLGKWCSEKTETGQELECLQDHLDDLVVECRDIVGNLTELESEDIQIEALLMRACEPII
QNFCHDVADNQIDSGDLMECLIQNKHQKDMNEKCAIGVTHFQLVQMKDFRFSYKFKMACKEDVLKLCPNIKKKVDVVICLSTTVRNDTLQ
EAKEHRVSLKCRRQLRVEELEMTEDIRLEPDLYEACKSDIKNFCSAVQYGNAQIIECLKENKKQLSTRCHQKVFKLQETEMMDPELDYTL
MRVCKQMIKRFCPEADSKTMLQCLKQNKNSELMDPKCKQMITKRQITQNTDYRLNPMLRKACKADIPKFCHGILTKAKDDSELEGQVISC
LKLRYADQRLSSDCEDQIRIIIQESALDYRLDPQLQLHCSDEISSLCAEEAAAQEQTGQVEECLKVNLLKIKTELCKKEVLNMLKESKAD
IFVDPVLHTACALDIKHHCAAITPGRGRQMSCLMEALEDKRVRLQPECKKRLNDRIEMWSYAAKVAPADGFSDLAMQVMTSPSKNYILSV

--------------------------------------------------------------
>77044_77044_2_RPL8-GLG1_RPL8_chr8_146015154_ENST00000394920_GLG1_chr16_74566051_ENST00000422840_length(transcript)=5275nt_BP=965nt
TCTTTCGGCCGCGCTGGTGAACAGGTAGGTCATCCTTGCGGCCTTGCGGCATGGGCAGTATCCGCCGCCATCCTCTTCCGTGAGGCGCGC
TGAGACCCGGACCGGCCCTCCTGAGAGGATGCCGGTGCGGGCGCCCGCGGAGAGGGACCCGTCGCCATGGGCCGTGTGATCCGTGGACAG
AGGAAGGGCGCCGGGTCTGTGTTCCGCGCGCACGTGAAGCACCGTAAAGGCGCTGCGCGCCTGCGCGCCGTGGATTTCGCTGAGCGGCAC
GGCTACATCAAGGGCATCGTCAAGGACATCATCCACGACCCGGGCCGCGGCGCGCCCCTCGCCAAGGTGGTCTTCCGGGATCCGTATCGG
TTTAAGAAGCGGACGGAGCTGTTCATTGCCGCCGAGGGCATTCACACGGGCCAGTTTGTGTATTGCGGCAAGAAGGCCCAGCTCAACATT
GGCAATGTGCTCCCTGTGGGCACCATGCCTGAGGGTACAATCGTGTGCTGCCTGGAGGAGAAGCCTGGAGACCGTGGCAAGCTGGCCCGG
GCATCAGGGAACTATGCCACCGTTATCTCCCACAACCCTGAGACCAAGAAGACCCGTGTGAAGCTGCCCTCCGGCTCCAAGAAGGTTATC
TCCTCAGCCAACAGAGCTGTGGTTGGTGTGGTGGCTGGAGGTGGCCGAATTGACAAACCCATCTTGAAGGCTGGCCGGGCGTACCACAAA
TATAAGGCAAAGAGGAACTGCTGGCCACGAGTACGGGGTGTGGCCATGAATCCTGTGGAGCATCCTTTTGGAGGTGGCAACCACCAGCAC
ATCGGCAAGCCCTCCACCATCCGCAGAGATGCCCCTGCTGGCCGCAAAGTGGGTCTCATTGCTGCCCGCCGGACTGGACGTCTCCGGGGA
ACCAAGACTGTGCAGGAGAAAGAGAACTAGTGCTGAGGGCCTCAATAAAGTTTGTGTTTATGCCACCTGAAAATGAAATTTCTTCAGACT
GCAATCATTTGTTGTGGAATTATAAGCTGAACCTAACTACAGATCCCAAATTTGAATCTGTGGCCAGAGAGGTTTGCAAATCTACTATAA
CAGAGATTAAAGAATGTGCTGATGAACCGGTTGGAAAAGGTTACATGGTTTCCTGCTTGGTGGATCACCGAGGCAACATCACTGAGTATC
AGTGTCACCAGTACATTACCAAGATGACGGCCATCATTTTTAGTGATTACCGTTTAATCTGTGGCTTCATGGATGACTGCAAAAATGACA
TCAACATTCTGAAATGTGGCAGTATTCGGCTTGGAGAAAAGGATGCACATTCACAAGGTGAGGTGGTATCATGCTTGGAGAAAGGCCTGG
TGAAAGAAGCAGAAGAAAGAGAACCCAAGATTCAAGTTTCTGAACTCTGCAAGAAAGCCATTCTCCGGGTGGCTGAGCTGTCATCGGATG
ACTTTCACTTAGACCGGCATTTATATTTTGCTTGCCGAGATGATCGGGAGCGTTTTTGTGAAAATACACAAGCTGGTGAGGGCAGAGTGT
ATAAGTGCCTCTTTAACCATAAATTTGAAGAATCCATGAGTGAAAAGTGTCGAGAAGCACTTACAACCCGCCAAAAGCTGATTGCCCAGG
ATTATAAAGTCAGTTATTCATTGGCCAAATCCTGTAAAAGTGACTTGAAGAAATACCGGTGCAATGTGGAAAACCTTCCGCGATCGCGTG
AAGCCAGGCTCTCCTACTTGTTAATGTGCCTGGAGTCAGCTGTACACAGAGGGCGACAAGTCAGCAGTGAGTGCCAGGGGGAGATGCTGG
ATTACCGACGCATGTTGATGGAAGACTTTTCTCTGAGCCCTGAGATCATCCTAAGCTGTCGGGGGGAGATTGAACACCATTGTTCCGGAT
TACATCGAAAAGGGCGGACCCTACACTGTCTGATGAAAGTAGTTCGAGGGGAGAAGGGGAACCTTGGAATGAACTGCCAGCAGGCGCTTC
AAACACTGATTCAGGAGACTGACCCTGGTGCAGATTACCGCATTGATCGAGCTTTGAATGAAGCTTGTGAATCTGTAATCCAGACAGCCT
GCAAACATATAAGATCTGGAGACCCAATGATCTTGTCGTGCCTGATGGAACATTTATACACAGAGAAGATGGTAGAAGACTGTGAACACC
GTCTCTTAGAGCTGCAGTATTTCATCTCCCGGGATTGGAAGCTGGACCCTGTCCTGTACCGCAAGTGCCAGGGAGACGCTTCTCGTCTTT
GCCACACCCACGGTTGGAATGAGACCAGTGAATTTATGCCTCAGGGAGCTGTGTTCTCTTGTTTATACAGACACGCCTACCGCACTGAGG
AACAGGGAAGGAGGCTCTCACGGGAGTGCCGAGCTGAAGTCCAAAGGATCCTACACCAGCGTGCCATGGATGTCAAGCTGGATCCTGCCC
TCCAGGATAAGTGCCTGATTGATCTGGGAAAATGGTGCAGTGAGAAAACAGAGACTGGACAGGAGCTGGAGTGCCTTCAGGACCATCTGG
ATGACTTGGTGGTGGAGTGTAGAGATATAGTTGGCAACCTCACTGAGTTAGAATCAGAGGATATTCAAATAGAAGCCTTGCTGATGAGAG
CCTGTGAGCCCATAATTCAGAACTTCTGCCACGATGTGGCAGATAACCAGATAGACTCTGGGGACCTGATGGAGTGTCTGATACAGAACA
AACACCAGAAGGACATGAACGAGAAGTGTGCCATCGGAGTTACCCACTTCCAGCTGGTGCAGATGAAGGATTTTCGGTTTTCTTACAAGT
TTAAAATGGCCTGCAAGGAGGACGTGTTGAAGCTTTGCCCAAACATAAAAAAGAAGGTGGACGTGGTGATCTGCCTGAGCACGACCGTGC
GCAATGACACTCTGCAGGAAGCCAAGGAGCACAGGGTGTCCCTGAAGTGCCGCAGGCAGCTCCGTGTGGAGGAGCTGGAGATGACGGAGG
ACATCCGCTTGGAGCCAGATCTATACGAAGCCTGCAAGAGTGACATCAAAAACTTCTGTTCCGCTGTGCAATATGGCAACGCTCAGATTA
TCGAATGTCTGAAAGAAAACAAGAAGCAGCTAAGCACCCGCTGCCACCAAAAAGTATTTAAGCTGCAGGAGACAGAGATGATGGACCCAG
AGCTAGACTACACCCTCATGAGGGTCTGCAAGCAGATGATAAAGAGGTTCTGTCCGGAAGCAGATTCTAAAACCATGTTGCAGTGCTTGA
AGCAAAATAAAAACAGTGAATTGATGGATCCCAAATGCAAACAGATGATAACCAAGCGCCAGATCACCCAGAACACAGATTACCGCTTAA
ACCCCATGTTAAGAAAAGCCTGTAAAGCTGACATTCCTAAATTCTGTCACGGTATCCTGACTAAGGCCAAGGATGATTCAGAATTAGAAG
GACAAGTCATCTCTTGCCTGAAGCTGAGATATGCTGACCAGCGCCTGTCTTCAGACTGTGAAGACCAGATCCGAATCATTATCCAGGAGT
CCGCCCTGGACTACCGCCTGGATCCTCAGCTCCAGCTGCACTGCTCAGACGAGATCTCCAGTCTATGTGCTGAAGAAGCAGCAGCCCAAG
AGCAGACAGGTCAGGTGGAGGAGTGCCTCAAGGTCAACCTGCTCAAGATCAAAACAGAATTGTGTAAAAAGGAAGTGCTAAACATGCTGA
AGGAAAGCAAAGCAGACATCTTTGTTGACCCGGTACTTCATACTGCTTGTGCCCTGGACATTAAACACCACTGCGCAGCCATCACCCCTG
GCCGCGGGCGTCAAATGTCCTGTCTCATGGAAGCACTGGAGGATAAGCGGGTGAGGTTACAGCCCGAGTGCAAAAAGCGCCTCAATGACC
GGATTGAGATGTGGAGTTACGCAGCAAAGGTGGCCCCAGCAGATGGCTTCTCTGATCTTGCCATGCAAGTAATGACGTCTCCATCTAAGA
ACTACATTCTCTCTGTGATCAGTGGGAGCATCTGTATATTGTTCCTGATTGGCCTGATGTGTGGACGGATCACCAAGCGAGTGACACGAG
AGCTCAAGGACAGGTAGAGCCACCTTGACCACCAAAGGAACTACCTATCCAGTGCCCAGTTTGTACAGCCCTCTTGTATAGCATCCCCAC
TCACCTCGCTCTTCTCAGAAGTGACACCAACCCCGTGTTAGAGCATTAGCAGATGTCCACTGCGTTGTCCCATCCAGCCTCCACTCGTGT
CCATGGTGTCCTCCTCCTCCTCACCGTGCAGCAGCAGCAGCTGGTCGCTGGGGTTACTGCCTTTGTTTGGCAAACTTGGGTTTACCTGCC
TGTAGACAAGTCTCTCTCATACCAACAGAACTTCCGGTACTTCCAGAACCAACTCACCTGACCTGCAACTCAAAGGCTTTTTTAAGAAAA
CCACCAAAAAAAAAAATTTTTTTAAAGAAAAAAATGTATATAGTAACGCATCTCCTCCAGGCTTGATTTGGGCAATGGGGTTATGTCTTT
CATATGACTGTGTAAAACAAAGACAGGACTTGGAGGGGAAGCACACCACCCAGTGTGCCATGACTGAGGTGTCTCGTTCATCTCTCAGAA
GCACCTTGGGGCCTCGCCAGGGCCGTGGTCTTCACCGAGGCGTGGGTGGGCAGCCGTTCCCCAGGCTGTGTGGGGTCCTGCTTTCTTCTG
CTGAGACAGTGACGCTTTCCAGTTTCCACCCTAATCAGCCACTGCTGGTCACAGCCCCACAGCCATGGGTATTTCTGTGGTCTCCTCGCT
TCATTGAAGCAAAGCATGAGCCTTCCTAGACAAGGGCAGCTGGGGAGGGGAAGGGACCGGAAGTTTGTGAAGTTGAACAGTCCATCCATC
TGCACTGAGAGGCTGGATCCTGAGTCCCGGGGCAGCAGGATCCCAGGAACCTTCCTCCTCCAGGGCAGCACAGGACTCAGCCATGTCTGG
ACCGGCCCTGCTGAGGCTACAGTCACTCTGGAAGCTCTGCGCTTCATCAGGAGGCAGGACTGTGGCGGGAGGGGTCCTTGAAGATGGGTG
TGGGGAGCAGTGGGTCAGGAAGTGGGAGCCAGAGGTTTGACTCACTTTGCTTTATTTTTCAGGCTACAATACAGGTCAGAGACAATGGCT
TATAAAGGTTTAGTGTGGTCTCAGGATGTGACAGGCAGTCCAGCCTGACCTTTCTGCACACTCCAGACAAACTTCCCAGACAAGCTCCTT

>77044_77044_2_RPL8-GLG1_RPL8_chr8_146015154_ENST00000394920_GLG1_chr16_74566051_ENST00000422840_length(amino acids)=1109AA_BP=76
MLATSTGCGHESCGASFWRWQPPAHRQALHHPQRCPCWPQSGSHCCPPDWTSPGNQDCAGERELVLRASIKFVFMPPENEISSDCNHLLW
NYKLNLTTDPKFESVAREVCKSTITEIKECADEPVGKGYMVSCLVDHRGNITEYQCHQYITKMTAIIFSDYRLICGFMDDCKNDINILKC
GSIRLGEKDAHSQGEVVSCLEKGLVKEAEEREPKIQVSELCKKAILRVAELSSDDFHLDRHLYFACRDDRERFCENTQAGEGRVYKCLFN
HKFEESMSEKCREALTTRQKLIAQDYKVSYSLAKSCKSDLKKYRCNVENLPRSREARLSYLLMCLESAVHRGRQVSSECQGEMLDYRRML
MEDFSLSPEIILSCRGEIEHHCSGLHRKGRTLHCLMKVVRGEKGNLGMNCQQALQTLIQETDPGADYRIDRALNEACESVIQTACKHIRS
GDPMILSCLMEHLYTEKMVEDCEHRLLELQYFISRDWKLDPVLYRKCQGDASRLCHTHGWNETSEFMPQGAVFSCLYRHAYRTEEQGRRL
SRECRAEVQRILHQRAMDVKLDPALQDKCLIDLGKWCSEKTETGQELECLQDHLDDLVVECRDIVGNLTELESEDIQIEALLMRACEPII
QNFCHDVADNQIDSGDLMECLIQNKHQKDMNEKCAIGVTHFQLVQMKDFRFSYKFKMACKEDVLKLCPNIKKKVDVVICLSTTVRNDTLQ
EAKEHRVSLKCRRQLRVEELEMTEDIRLEPDLYEACKSDIKNFCSAVQYGNAQIIECLKENKKQLSTRCHQKVFKLQETEMMDPELDYTL
MRVCKQMIKRFCPEADSKTMLQCLKQNKNSELMDPKCKQMITKRQITQNTDYRLNPMLRKACKADIPKFCHGILTKAKDDSELEGQVISC
LKLRYADQRLSSDCEDQIRIIIQESALDYRLDPQLQLHCSDEISSLCAEEAAAQEQTGQVEECLKVNLLKIKTELCKKEVLNMLKESKAD
IFVDPVLHTACALDIKHHCAAITPGRGRQMSCLMEALEDKRVRLQPECKKRLNDRIEMWSYAAKVAPADGFSDLAMQVMTSPSKNYILSV

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for RPL8-GLG1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for RPL8-GLG1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for RPL8-GLG1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source