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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RPLP0-NDUFA13 (FusionGDB2 ID:77081)

Fusion Gene Summary for RPLP0-NDUFA13

check button Fusion gene summary
Fusion gene informationFusion gene name: RPLP0-NDUFA13
Fusion gene ID: 77081
HgeneTgene
Gene symbol

RPLP0

NDUFA13

Gene ID

6175

51079

Gene nameribosomal protein lateral stalk subunit P0NADH:ubiquinone oxidoreductase subunit A13
SynonymsL10E|LP0|P0|PRLP0|RPP0B16.6|CDA016|CGI-39|GRIM-19|GRIM19|MC1DN28
Cytomap

12q24.23

19p13.11

Type of geneprotein-codingprotein-coding
Description60S acidic ribosomal protein P060S ribosomal protein L10Eacidic ribosomal phosphoprotein P0large ribosomal subunit protein uL10neutral ribosomal phosphoprotein P0ribosomal protein, large, P0NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13CI-B16.6NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13NADH-ubiquinone oxidoreductase B16.6 subunitcell death regulatory protein GRIM-19cell death-regulatory protein GRIM19complex I
Modification date2020031320200313
UniProtAcc.

Q9P0J0

Ensembl transtripts involved in fusion geneENST00000228306, ENST00000313104, 
ENST00000392514, ENST00000546989, 
ENST00000550296, ENST00000551150, 
ENST00000552292, 		ENST00000252576, 
ENST00000428459, ENST00000503283, 
ENST00000507754, ENST00000512771, 
Fusion gene scores* DoF score10 X 11 X 3=33010 X 9 X 7=630
# samples 1113
** MAII scorelog2(11/330*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/630*10)=-2.27684020535882
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPLP0 [Title/Abstract] AND NDUFA13 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRPLP0(120635175)-NDUFA13(19627052), # samples:1
RPLP0(120635169)-NDUFA13(19627042), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNDUFA13

GO:0030308

negative regulation of cell growth

10924506

TgeneNDUFA13

GO:0035458

cellular response to interferon-beta

17297443

TgeneNDUFA13

GO:0045039

protein import into mitochondrial inner membrane

23271731

TgeneNDUFA13

GO:0045892

negative regulation of transcription, DNA-templated

12867595

TgeneNDUFA13

GO:0071300

cellular response to retinoic acid

17297443

TgeneNDUFA13

GO:0097190

apoptotic signaling pathway

10924506


check buttonFusion gene breakpoints across RPLP0 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NDUFA13 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAF132973RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
ChiTaRS5.0N/AAF155662RPLP0chr12

120635169

+NDUFA13chr19

19627042

+


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Fusion Gene ORF analysis for RPLP0-NDUFA13

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000228306ENST00000252576RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000228306ENST00000428459RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000228306ENST00000503283RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000228306ENST00000507754RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000228306ENST00000512771RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000313104ENST00000252576RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000313104ENST00000428459RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000313104ENST00000503283RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000313104ENST00000507754RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000313104ENST00000512771RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000392514ENST00000252576RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000392514ENST00000428459RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000392514ENST00000503283RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000392514ENST00000507754RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000392514ENST00000512771RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000546989ENST00000252576RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000546989ENST00000428459RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000546989ENST00000503283RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000546989ENST00000507754RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000546989ENST00000512771RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000550296ENST00000252576RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000550296ENST00000428459RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000550296ENST00000503283RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000550296ENST00000507754RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000550296ENST00000512771RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000551150ENST00000252576RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000551150ENST00000428459RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000551150ENST00000503283RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000551150ENST00000507754RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000551150ENST00000512771RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000552292ENST00000252576RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000552292ENST00000428459RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000552292ENST00000503283RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000552292ENST00000507754RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-3CDSENST00000552292ENST00000512771RPLP0chr12

120635175

+NDUFA13chr19

19627052

+
intron-5UTRENST00000228306ENST00000252576RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000228306ENST00000428459RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000228306ENST00000503283RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000228306ENST00000507754RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000228306ENST00000512771RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000313104ENST00000252576RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000313104ENST00000428459RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000313104ENST00000503283RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000313104ENST00000507754RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000313104ENST00000512771RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000392514ENST00000252576RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000392514ENST00000428459RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000392514ENST00000503283RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000392514ENST00000507754RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000392514ENST00000512771RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000546989ENST00000252576RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000546989ENST00000428459RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000546989ENST00000503283RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000546989ENST00000507754RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000546989ENST00000512771RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000550296ENST00000252576RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000550296ENST00000428459RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000550296ENST00000503283RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000550296ENST00000507754RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000550296ENST00000512771RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000551150ENST00000252576RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000551150ENST00000428459RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000551150ENST00000503283RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000551150ENST00000507754RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000551150ENST00000512771RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000552292ENST00000252576RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000552292ENST00000428459RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000552292ENST00000503283RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000552292ENST00000507754RPLP0chr12

120635169

+NDUFA13chr19

19627042

+
intron-5UTRENST00000552292ENST00000512771RPLP0chr12

120635169

+NDUFA13chr19

19627042

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for RPLP0-NDUFA13


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RPLP0-NDUFA13


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:120635175/:19627052)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NDUFA13

Q9P0J0

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371). Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (PubMed:15753091). {ECO:0000269|PubMed:12628925, ECO:0000269|PubMed:12867595, ECO:0000269|PubMed:15753091, ECO:0000269|PubMed:27626371}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for RPLP0-NDUFA13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for RPLP0-NDUFA13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RPLP0-NDUFA13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RPLP0-NDUFA13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource