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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RPRD2-CA14 (FusionGDB2 ID:77255)

Fusion Gene Summary for RPRD2-CA14

check button Fusion gene summary
Fusion gene informationFusion gene name: RPRD2-CA14
Fusion gene ID: 77255
HgeneTgene
Gene symbol

RPRD2

CA14

Gene ID

23248

23632

Gene nameregulation of nuclear pre-mRNA domain containing 2carbonic anhydrase 14
SynonymsHSPC099|KIAA0460CAXiV
Cytomap

1q21.2

1q21.2

Type of geneprotein-codingprotein-coding
Descriptionregulation of nuclear pre-mRNA domain-containing protein 2carbonic anhydrase 14CA-XIVcarbonate dehydratase XIVcarbonic anhydrase XIVcarbonic dehydratase
Modification date2020031320200313
UniProtAcc.

Q9ULX7

Ensembl transtripts involved in fusion geneENST00000492220, ENST00000369067, 
ENST00000369068, ENST00000401000, 
ENST00000539519, 		ENST00000369111, 
Fusion gene scores* DoF score11 X 8 X 8=7043 X 3 X 4=36
# samples 135
** MAII scorelog2(13/704*10)=-2.43706380560884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RPRD2 [Title/Abstract] AND CA14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRPRD2(150337395)-CA14(150236993), # samples:2
RPRD2(150337395)-CA14(150232546), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RPRD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CA14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A13D-01ARPRD2chr1

150416853

-CA14chr1

150232546

+
ChimerDB4LIHCTCGA-G3-A6UC-01ARPRD2chr1

150337395

-CA14chr1

150236993

+
ChimerDB4LIHCTCGA-G3-A6UC-01ARPRD2chr1

150337395

+CA14chr1

150236993

+
ChimerDB4LUADTCGA-55-7227-01ARPRD2chr1

150337395

-CA14chr1

150232546

+
ChimerDB4LUADTCGA-55-7227-01ARPRD2chr1

150337395

+CA14chr1

150232546

+


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Fusion Gene ORF analysis for RPRD2-CA14

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000492220ENST00000369111RPRD2chr1

150416853

-CA14chr1

150232546

+
In-frameENST00000369067ENST00000369111RPRD2chr1

150337395

+CA14chr1

150236993

+
In-frameENST00000369067ENST00000369111RPRD2chr1

150337395

+CA14chr1

150232546

+
In-frameENST00000369068ENST00000369111RPRD2chr1

150416853

-CA14chr1

150232546

+
In-frameENST00000369068ENST00000369111RPRD2chr1

150337395

+CA14chr1

150236993

+
In-frameENST00000369068ENST00000369111RPRD2chr1

150337395

+CA14chr1

150232546

+
In-frameENST00000401000ENST00000369111RPRD2chr1

150416853

-CA14chr1

150232546

+
In-frameENST00000401000ENST00000369111RPRD2chr1

150337395

+CA14chr1

150236993

+
In-frameENST00000401000ENST00000369111RPRD2chr1

150337395

+CA14chr1

150232546

+
In-frameENST00000539519ENST00000369111RPRD2chr1

150416853

-CA14chr1

150232546

+
In-frameENST00000539519ENST00000369111RPRD2chr1

150337395

+CA14chr1

150236993

+
In-frameENST00000539519ENST00000369111RPRD2chr1

150337395

+CA14chr1

150232546

+
intron-3CDSENST00000369067ENST00000369111RPRD2chr1

150416853

-CA14chr1

150232546

+
intron-3CDSENST00000492220ENST00000369111RPRD2chr1

150337395

+CA14chr1

150236993

+
intron-3CDSENST00000492220ENST00000369111RPRD2chr1

150337395

+CA14chr1

150232546

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000401000RPRD2chr1150337395+ENST00000369111CA14chr1150236993+756270247282
ENST00000539519RPRD2chr1150337395+ENST00000369111CA14chr1150236993+71322749426775
ENST00000369067RPRD2chr1150337395+ENST00000369111CA14chr1150236993+69821247925275
ENST00000369068RPRD2chr1150337395+ENST00000369111CA14chr1150236993+69520947624975
ENST00000401000RPRD2chr1150337395+ENST00000369111CA14chr1150232546+1648270651228387
ENST00000539519RPRD2chr1150337395+ENST00000369111CA14chr1150232546+1605227221185387
ENST00000369067RPRD2chr1150337395+ENST00000369111CA14chr1150232546+159021271170387
ENST00000369068RPRD2chr1150337395+ENST00000369111CA14chr1150232546+158720941167387
ENST00000401000RPRD2chr1150416853-ENST00000369111CA14chr1150232546+2059681651639524
ENST00000539519RPRD2chr1150416853-ENST00000369111CA14chr1150232546+2016638221596524
ENST00000369068RPRD2chr1150416853-ENST00000369111CA14chr1150232546+207669841656550

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000401000ENST00000369111RPRD2chr1150337395+CA14chr1150236993+0.0836276560.91637236
ENST00000539519ENST00000369111RPRD2chr1150337395+CA14chr1150236993+0.104035390.89596456
ENST00000369067ENST00000369111RPRD2chr1150337395+CA14chr1150236993+0.0842534750.9157465
ENST00000369068ENST00000369111RPRD2chr1150337395+CA14chr1150236993+0.0873231140.91267693
ENST00000401000ENST00000369111RPRD2chr1150337395+CA14chr1150232546+0.013285860.98671407
ENST00000539519ENST00000369111RPRD2chr1150337395+CA14chr1150232546+0.0123230590.987677
ENST00000369067ENST00000369111RPRD2chr1150337395+CA14chr1150232546+0.0124164980.98758346
ENST00000369068ENST00000369111RPRD2chr1150337395+CA14chr1150232546+0.0124763330.98752373
ENST00000401000ENST00000369111RPRD2chr1150416853-CA14chr1150232546+0.0069129690.993087
ENST00000539519ENST00000369111RPRD2chr1150416853-CA14chr1150232546+0.0057187980.9942812
ENST00000369068ENST00000369111RPRD2chr1150416853-CA14chr1150232546+0.0110805070.98891944

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Fusion Genomic Features for RPRD2-CA14


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RPRD2chr1150337395+CA14chr1150232545+0.0001759580.9998241
RPRD2chr1150337395+CA14chr1150236992+3.94E-070.99999964
RPRD2chr1150337395+CA14chr1150232545+0.0001759580.9998241
RPRD2chr1150337395+CA14chr1150236992+3.94E-070.99999964

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RPRD2-CA14


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:150337395/chr1:150236993)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CA14

Q9ULX7

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Reversible hydration of carbon dioxide.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRPRD2chr1:150337395chr1:150232546ENST00000369067+134_1968153.0Compositional biasNote=Gly/Ser-rich
HgeneRPRD2chr1:150337395chr1:150232546ENST00000369068+1114_19681462.0Compositional biasNote=Gly/Ser-rich
HgeneRPRD2chr1:150337395chr1:150232546ENST00000401000+1104_19681436.0Compositional biasNote=Gly/Ser-rich
HgeneRPRD2chr1:150337395chr1:150236993ENST00000369067+134_1968153.0Compositional biasNote=Gly/Ser-rich
HgeneRPRD2chr1:150337395chr1:150236993ENST00000369068+1114_19681462.0Compositional biasNote=Gly/Ser-rich
HgeneRPRD2chr1:150337395chr1:150236993ENST00000401000+1104_19681436.0Compositional biasNote=Gly/Ser-rich
HgeneRPRD2chr1:150416853chr1:150232546ENST00000369068-6114_192311462.0Compositional biasNote=Gly/Ser-rich
HgeneRPRD2chr1:150416853chr1:150232546ENST00000401000-5104_192051436.0Compositional biasNote=Gly/Ser-rich
HgeneRPRD2chr1:150416853chr1:150232546ENST00000369068-61119_1492311462.0DomainCID
HgeneRPRD2chr1:150416853chr1:150232546ENST00000401000-51019_1492051436.0DomainCID
TgeneCA14chr1:150337395chr1:150232546ENST0000036911101120_27818338.0DomainAlpha-carbonic anhydrase
TgeneCA14chr1:150416853chr1:150232546ENST0000036911101120_27818338.0DomainAlpha-carbonic anhydrase
TgeneCA14chr1:150337395chr1:150232546ENST00000369111011217_21818338.0RegionSubstrate binding
TgeneCA14chr1:150416853chr1:150232546ENST00000369111011217_21818338.0RegionSubstrate binding
TgeneCA14chr1:150337395chr1:150232546ENST0000036911101116_29018338.0Topological domainExtracellular
TgeneCA14chr1:150337395chr1:150232546ENST00000369111011312_33718338.0Topological domainCytoplasmic
TgeneCA14chr1:150416853chr1:150232546ENST0000036911101116_29018338.0Topological domainExtracellular
TgeneCA14chr1:150416853chr1:150232546ENST00000369111011312_33718338.0Topological domainCytoplasmic
TgeneCA14chr1:150337395chr1:150232546ENST00000369111011291_31118338.0TransmembraneHelical
TgeneCA14chr1:150416853chr1:150232546ENST00000369111011291_31118338.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRPRD2chr1:150337395chr1:150232546ENST00000369067+131054_105768153.0Compositional biasNote=Poly-Gln
HgeneRPRD2chr1:150337395chr1:150232546ENST00000369067+131152_115868153.0Compositional biasNote=Poly-Gly
HgeneRPRD2chr1:150337395chr1:150232546ENST00000369067+131195_145968153.0Compositional biasNote=Pro-rich
HgeneRPRD2chr1:150337395chr1:150232546ENST00000369067+13457_95068153.0Compositional biasNote=Ser-rich
HgeneRPRD2chr1:150337395chr1:150232546ENST00000369068+1111054_1057681462.0Compositional biasNote=Poly-Gln
HgeneRPRD2chr1:150337395chr1:150232546ENST00000369068+1111152_1158681462.0Compositional biasNote=Poly-Gly
HgeneRPRD2chr1:150337395chr1:150232546ENST00000369068+1111195_1459681462.0Compositional biasNote=Pro-rich
HgeneRPRD2chr1:150337395chr1:150232546ENST00000369068+111457_950681462.0Compositional biasNote=Ser-rich
HgeneRPRD2chr1:150337395chr1:150232546ENST00000401000+1101054_1057681436.0Compositional biasNote=Poly-Gln
HgeneRPRD2chr1:150337395chr1:150232546ENST00000401000+1101152_1158681436.0Compositional biasNote=Poly-Gly
HgeneRPRD2chr1:150337395chr1:150232546ENST00000401000+1101195_1459681436.0Compositional biasNote=Pro-rich
HgeneRPRD2chr1:150337395chr1:150232546ENST00000401000+110457_950681436.0Compositional biasNote=Ser-rich
HgeneRPRD2chr1:150337395chr1:150236993ENST00000369067+131054_105768153.0Compositional biasNote=Poly-Gln
HgeneRPRD2chr1:150337395chr1:150236993ENST00000369067+131152_115868153.0Compositional biasNote=Poly-Gly
HgeneRPRD2chr1:150337395chr1:150236993ENST00000369067+131195_145968153.0Compositional biasNote=Pro-rich
HgeneRPRD2chr1:150337395chr1:150236993ENST00000369067+13457_95068153.0Compositional biasNote=Ser-rich
HgeneRPRD2chr1:150337395chr1:150236993ENST00000369068+1111054_1057681462.0Compositional biasNote=Poly-Gln
HgeneRPRD2chr1:150337395chr1:150236993ENST00000369068+1111152_1158681462.0Compositional biasNote=Poly-Gly
HgeneRPRD2chr1:150337395chr1:150236993ENST00000369068+1111195_1459681462.0Compositional biasNote=Pro-rich
HgeneRPRD2chr1:150337395chr1:150236993ENST00000369068+111457_950681462.0Compositional biasNote=Ser-rich
HgeneRPRD2chr1:150337395chr1:150236993ENST00000401000+1101054_1057681436.0Compositional biasNote=Poly-Gln
HgeneRPRD2chr1:150337395chr1:150236993ENST00000401000+1101152_1158681436.0Compositional biasNote=Poly-Gly
HgeneRPRD2chr1:150337395chr1:150236993ENST00000401000+1101195_1459681436.0Compositional biasNote=Pro-rich
HgeneRPRD2chr1:150337395chr1:150236993ENST00000401000+110457_950681436.0Compositional biasNote=Ser-rich
HgeneRPRD2chr1:150416853chr1:150232546ENST00000369067-131054_10570153.0Compositional biasNote=Poly-Gln
HgeneRPRD2chr1:150416853chr1:150232546ENST00000369067-131152_11580153.0Compositional biasNote=Poly-Gly
HgeneRPRD2chr1:150416853chr1:150232546ENST00000369067-131195_14590153.0Compositional biasNote=Pro-rich
HgeneRPRD2chr1:150416853chr1:150232546ENST00000369067-13457_9500153.0Compositional biasNote=Ser-rich
HgeneRPRD2chr1:150416853chr1:150232546ENST00000369067-134_190153.0Compositional biasNote=Gly/Ser-rich
HgeneRPRD2chr1:150416853chr1:150232546ENST00000369068-6111054_10572311462.0Compositional biasNote=Poly-Gln
HgeneRPRD2chr1:150416853chr1:150232546ENST00000369068-6111152_11582311462.0Compositional biasNote=Poly-Gly
HgeneRPRD2chr1:150416853chr1:150232546ENST00000369068-6111195_14592311462.0Compositional biasNote=Pro-rich
HgeneRPRD2chr1:150416853chr1:150232546ENST00000369068-611457_9502311462.0Compositional biasNote=Ser-rich
HgeneRPRD2chr1:150416853chr1:150232546ENST00000401000-5101054_10572051436.0Compositional biasNote=Poly-Gln
HgeneRPRD2chr1:150416853chr1:150232546ENST00000401000-5101152_11582051436.0Compositional biasNote=Poly-Gly
HgeneRPRD2chr1:150416853chr1:150232546ENST00000401000-5101195_14592051436.0Compositional biasNote=Pro-rich
HgeneRPRD2chr1:150416853chr1:150232546ENST00000401000-510457_9502051436.0Compositional biasNote=Ser-rich
HgeneRPRD2chr1:150337395chr1:150232546ENST00000369067+1319_14968153.0DomainCID
HgeneRPRD2chr1:150337395chr1:150232546ENST00000369068+11119_149681462.0DomainCID
HgeneRPRD2chr1:150337395chr1:150232546ENST00000401000+11019_149681436.0DomainCID
HgeneRPRD2chr1:150337395chr1:150236993ENST00000369067+1319_14968153.0DomainCID
HgeneRPRD2chr1:150337395chr1:150236993ENST00000369068+11119_149681462.0DomainCID
HgeneRPRD2chr1:150337395chr1:150236993ENST00000401000+11019_149681436.0DomainCID
HgeneRPRD2chr1:150416853chr1:150232546ENST00000369067-1319_1490153.0DomainCID
TgeneCA14chr1:150337395chr1:150236993ENST0000036911191120_278315338.0DomainAlpha-carbonic anhydrase
TgeneCA14chr1:150337395chr1:150236993ENST00000369111911217_218315338.0RegionSubstrate binding
TgeneCA14chr1:150337395chr1:150236993ENST0000036911191116_290315338.0Topological domainExtracellular
TgeneCA14chr1:150337395chr1:150236993ENST00000369111911312_337315338.0Topological domainCytoplasmic
TgeneCA14chr1:150337395chr1:150236993ENST00000369111911291_311315338.0TransmembraneHelical


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Fusion Gene Sequence for RPRD2-CA14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>77255_77255_1_RPRD2-CA14_RPRD2_chr1_150337395_ENST00000369067_CA14_chr1_150232546_ENST00000369111_length(transcript)=1590nt_BP=212nt
CGGGAAGATGGCGGCCGGCGGCGGCGGAGGCAGCAGTAAGGCCTCCTCCTCGTCGGCCTCTTCGGCAGGGGCTCTGGAGTCCTCGTTGGA
TCGAAAATTCCAGTCGGTAACCAACACCATGGAGTCCATTCAAGGCTTGTCGTCTTGGTGTATAGAGAACAAAAAACACCACAGTACTAT
CGTCTATCATTGGATGAAGTGGCTCCGGAGATGTCAACACTGGACGTATGAGGGCCCACATGGTCAGGACCATTGGCCAGCCTCTTACCC
TGAGTGTGGAAACAATGCCCAGTCGCCCATCGATATTCAGACAGACAGTGTGACATTTGACCCTGATTTGCCTGCTCTGCAGCCCCACGG
ATATGACCAGCCTGGCACCGAGCCTTTGGACCTGCACAACAATGGCCACACAGTGCAACTCTCTCTGCCCTCTACCCTGTATCTGGGTGG
ACTTCCCCGAAAATATGTAGCTGCCCAGCTCCACCTGCACTGGGGTCAGAAAGGATCCCCAGGGGGGTCAGAACACCAGATCAACAGTGA
AGCCACATTTGCAGAGCTCCACATTGTACATTATGACTCTGATTCCTATGACAGCTTGAGTGAGGCTGCTGAGAGGCCTCAGGGCCTGGC
TGTCCTGGGCATCCTAATTGAGGTGGGTGAGACTAAGAATATAGCTTATGAACACATTCTGAGTCACTTGCATGAAGTCAGGCATAAAGA
TCAGAAGACCTCAGTGCCTCCCTTCAACCTAAGAGAGCTGCTCCCCAAACAGCTGGGGCAGTACTTCCGCTACAATGGCTCGCTCACAAC
TCCCCCTTGCTACCAGAGTGTGCTCTGGACAGTTTTTTATAGAAGGTCCCAGATTTCAATGGAACAGCTGGAAAAGCTTCAGGGGACATT
GTTCTCCACAGAAGAGGAGCCCTCTAAGCTTCTGGTACAGAACTACCGAGCCCTTCAGCCTCTCAATCAGCGCATGGTCTTTGCTTCTTT
CATCCAAGCAGGATCCTCGTATACCACAGGTGAAATGCTGAGTCTAGGTGTAGGAATCTTGGTTGGCTGTCTCTGCCTTCTCCTGGCTGT
TTATTTCATTGCTAGAAAGATTCGGAAGAAGAGGCTGGAAAACCGAAAGAGTGTGGTCTTCACCTCAGCACAAGCCACGACTGAGGCATA
AATTCCTTCTCAGATACCATGGATGTGGATGACTTCCCTTCATGCCTATCAGGAAGCCTCTAAAATGGGGTGTAGGATCTGGCCAGAAAC
ACTGTAGGAGTAGTAAGCAGATGTCCTCCTTCCCCTGGACATCTCCTAGAGAGGAATGGACCCAGGCTGTCATTCCAGGAAGAACTGCAG
AGCCTTCAGCCTCTCCAAACATGTAGGAGGAAATGAGGAAATCGCTGTGTTGTTAATGCAGAGAACAAACTCTGTTTAGTTGCAGGGGAA
GTTTGGGATATACCCCAAAGTCCTCTACCCCCTCACTTTTATGGCCCTTTCCCTAGATATACTGCGGGATCTCTCCTTAGGATAAAGAGT

>77255_77255_1_RPRD2-CA14_RPRD2_chr1_150337395_ENST00000369067_CA14_chr1_150232546_ENST00000369111_length(amino acids)=387AA_BP=69
MAAGGGGGSSKASSSSASSAGALESSLDRKFQSVTNTMESIQGLSSWCIENKKHHSTIVYHWMKWLRRCQHWTYEGPHGQDHWPASYPEC
GNNAQSPIDIQTDSVTFDPDLPALQPHGYDQPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGGSEHQINSEAT
FAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSHLHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPP
CYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGEMLSLGVGILVGCLCLLLAVYF

--------------------------------------------------------------
>77255_77255_2_RPRD2-CA14_RPRD2_chr1_150337395_ENST00000369067_CA14_chr1_150236993_ENST00000369111_length(transcript)=698nt_BP=212nt
CGGGAAGATGGCGGCCGGCGGCGGCGGAGGCAGCAGTAAGGCCTCCTCCTCGTCGGCCTCTTCGGCAGGGGCTCTGGAGTCCTCGTTGGA
TCGAAAATTCCAGTCGGTAACCAACACCATGGAGTCCATTCAAGGCTTGTCGTCTTGGTGTATAGAGAACAAAAAACACCACAGTACTAT
CGTCTATCATTGGATGAAGTGGCTCCGGAGATGAAGAAGAGGCTGGAAAACCGAAAGAGTGTGGTCTTCACCTCAGCACAAGCCACGACT
GAGGCATAAATTCCTTCTCAGATACCATGGATGTGGATGACTTCCCTTCATGCCTATCAGGAAGCCTCTAAAATGGGGTGTAGGATCTGG
CCAGAAACACTGTAGGAGTAGTAAGCAGATGTCCTCCTTCCCCTGGACATCTCCTAGAGAGGAATGGACCCAGGCTGTCATTCCAGGAAG
AACTGCAGAGCCTTCAGCCTCTCCAAACATGTAGGAGGAAATGAGGAAATCGCTGTGTTGTTAATGCAGAGAACAAACTCTGTTTAGTTG
CAGGGGAAGTTTGGGATATACCCCAAAGTCCTCTACCCCCTCACTTTTATGGCCCTTTCCCTAGATATACTGCGGGATCTCTCCTTAGGA

>77255_77255_2_RPRD2-CA14_RPRD2_chr1_150337395_ENST00000369067_CA14_chr1_150236993_ENST00000369111_length(amino acids)=75AA_BP=

--------------------------------------------------------------
>77255_77255_3_RPRD2-CA14_RPRD2_chr1_150337395_ENST00000369068_CA14_chr1_150232546_ENST00000369111_length(transcript)=1587nt_BP=209nt
GAAGATGGCGGCCGGCGGCGGCGGAGGCAGCAGTAAGGCCTCCTCCTCGTCGGCCTCTTCGGCAGGGGCTCTGGAGTCCTCGTTGGATCG
AAAATTCCAGTCGGTAACCAACACCATGGAGTCCATTCAAGGCTTGTCGTCTTGGTGTATAGAGAACAAAAAACACCACAGTACTATCGT
CTATCATTGGATGAAGTGGCTCCGGAGATGTCAACACTGGACGTATGAGGGCCCACATGGTCAGGACCATTGGCCAGCCTCTTACCCTGA
GTGTGGAAACAATGCCCAGTCGCCCATCGATATTCAGACAGACAGTGTGACATTTGACCCTGATTTGCCTGCTCTGCAGCCCCACGGATA
TGACCAGCCTGGCACCGAGCCTTTGGACCTGCACAACAATGGCCACACAGTGCAACTCTCTCTGCCCTCTACCCTGTATCTGGGTGGACT
TCCCCGAAAATATGTAGCTGCCCAGCTCCACCTGCACTGGGGTCAGAAAGGATCCCCAGGGGGGTCAGAACACCAGATCAACAGTGAAGC
CACATTTGCAGAGCTCCACATTGTACATTATGACTCTGATTCCTATGACAGCTTGAGTGAGGCTGCTGAGAGGCCTCAGGGCCTGGCTGT
CCTGGGCATCCTAATTGAGGTGGGTGAGACTAAGAATATAGCTTATGAACACATTCTGAGTCACTTGCATGAAGTCAGGCATAAAGATCA
GAAGACCTCAGTGCCTCCCTTCAACCTAAGAGAGCTGCTCCCCAAACAGCTGGGGCAGTACTTCCGCTACAATGGCTCGCTCACAACTCC
CCCTTGCTACCAGAGTGTGCTCTGGACAGTTTTTTATAGAAGGTCCCAGATTTCAATGGAACAGCTGGAAAAGCTTCAGGGGACATTGTT
CTCCACAGAAGAGGAGCCCTCTAAGCTTCTGGTACAGAACTACCGAGCCCTTCAGCCTCTCAATCAGCGCATGGTCTTTGCTTCTTTCAT
CCAAGCAGGATCCTCGTATACCACAGGTGAAATGCTGAGTCTAGGTGTAGGAATCTTGGTTGGCTGTCTCTGCCTTCTCCTGGCTGTTTA
TTTCATTGCTAGAAAGATTCGGAAGAAGAGGCTGGAAAACCGAAAGAGTGTGGTCTTCACCTCAGCACAAGCCACGACTGAGGCATAAAT
TCCTTCTCAGATACCATGGATGTGGATGACTTCCCTTCATGCCTATCAGGAAGCCTCTAAAATGGGGTGTAGGATCTGGCCAGAAACACT
GTAGGAGTAGTAAGCAGATGTCCTCCTTCCCCTGGACATCTCCTAGAGAGGAATGGACCCAGGCTGTCATTCCAGGAAGAACTGCAGAGC
CTTCAGCCTCTCCAAACATGTAGGAGGAAATGAGGAAATCGCTGTGTTGTTAATGCAGAGAACAAACTCTGTTTAGTTGCAGGGGAAGTT
TGGGATATACCCCAAAGTCCTCTACCCCCTCACTTTTATGGCCCTTTCCCTAGATATACTGCGGGATCTCTCCTTAGGATAAAGAGTTGC

>77255_77255_3_RPRD2-CA14_RPRD2_chr1_150337395_ENST00000369068_CA14_chr1_150232546_ENST00000369111_length(amino acids)=387AA_BP=69
MAAGGGGGSSKASSSSASSAGALESSLDRKFQSVTNTMESIQGLSSWCIENKKHHSTIVYHWMKWLRRCQHWTYEGPHGQDHWPASYPEC
GNNAQSPIDIQTDSVTFDPDLPALQPHGYDQPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGGSEHQINSEAT
FAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSHLHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPP
CYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGEMLSLGVGILVGCLCLLLAVYF

--------------------------------------------------------------
>77255_77255_4_RPRD2-CA14_RPRD2_chr1_150337395_ENST00000369068_CA14_chr1_150236993_ENST00000369111_length(transcript)=695nt_BP=209nt
GAAGATGGCGGCCGGCGGCGGCGGAGGCAGCAGTAAGGCCTCCTCCTCGTCGGCCTCTTCGGCAGGGGCTCTGGAGTCCTCGTTGGATCG
AAAATTCCAGTCGGTAACCAACACCATGGAGTCCATTCAAGGCTTGTCGTCTTGGTGTATAGAGAACAAAAAACACCACAGTACTATCGT
CTATCATTGGATGAAGTGGCTCCGGAGATGAAGAAGAGGCTGGAAAACCGAAAGAGTGTGGTCTTCACCTCAGCACAAGCCACGACTGAG
GCATAAATTCCTTCTCAGATACCATGGATGTGGATGACTTCCCTTCATGCCTATCAGGAAGCCTCTAAAATGGGGTGTAGGATCTGGCCA
GAAACACTGTAGGAGTAGTAAGCAGATGTCCTCCTTCCCCTGGACATCTCCTAGAGAGGAATGGACCCAGGCTGTCATTCCAGGAAGAAC
TGCAGAGCCTTCAGCCTCTCCAAACATGTAGGAGGAAATGAGGAAATCGCTGTGTTGTTAATGCAGAGAACAAACTCTGTTTAGTTGCAG
GGGAAGTTTGGGATATACCCCAAAGTCCTCTACCCCCTCACTTTTATGGCCCTTTCCCTAGATATACTGCGGGATCTCTCCTTAGGATAA

>77255_77255_4_RPRD2-CA14_RPRD2_chr1_150337395_ENST00000369068_CA14_chr1_150236993_ENST00000369111_length(amino acids)=75AA_BP=

--------------------------------------------------------------
>77255_77255_5_RPRD2-CA14_RPRD2_chr1_150337395_ENST00000401000_CA14_chr1_150232546_ENST00000369111_length(transcript)=1648nt_BP=270nt
CCGCTCCCGCCGCCGCCGCCGCCGCCGCCGCCAGAGGAGCAGCAGCGCTTGTGCAAACCGGGAAGATGGCGGCCGGCGGCGGCGGAGGCA
GCAGTAAGGCCTCCTCCTCGTCGGCCTCTTCGGCAGGGGCTCTGGAGTCCTCGTTGGATCGAAAATTCCAGTCGGTAACCAACACCATGG
AGTCCATTCAAGGCTTGTCGTCTTGGTGTATAGAGAACAAAAAACACCACAGTACTATCGTCTATCATTGGATGAAGTGGCTCCGGAGAT
GTCAACACTGGACGTATGAGGGCCCACATGGTCAGGACCATTGGCCAGCCTCTTACCCTGAGTGTGGAAACAATGCCCAGTCGCCCATCG
ATATTCAGACAGACAGTGTGACATTTGACCCTGATTTGCCTGCTCTGCAGCCCCACGGATATGACCAGCCTGGCACCGAGCCTTTGGACC
TGCACAACAATGGCCACACAGTGCAACTCTCTCTGCCCTCTACCCTGTATCTGGGTGGACTTCCCCGAAAATATGTAGCTGCCCAGCTCC
ACCTGCACTGGGGTCAGAAAGGATCCCCAGGGGGGTCAGAACACCAGATCAACAGTGAAGCCACATTTGCAGAGCTCCACATTGTACATT
ATGACTCTGATTCCTATGACAGCTTGAGTGAGGCTGCTGAGAGGCCTCAGGGCCTGGCTGTCCTGGGCATCCTAATTGAGGTGGGTGAGA
CTAAGAATATAGCTTATGAACACATTCTGAGTCACTTGCATGAAGTCAGGCATAAAGATCAGAAGACCTCAGTGCCTCCCTTCAACCTAA
GAGAGCTGCTCCCCAAACAGCTGGGGCAGTACTTCCGCTACAATGGCTCGCTCACAACTCCCCCTTGCTACCAGAGTGTGCTCTGGACAG
TTTTTTATAGAAGGTCCCAGATTTCAATGGAACAGCTGGAAAAGCTTCAGGGGACATTGTTCTCCACAGAAGAGGAGCCCTCTAAGCTTC
TGGTACAGAACTACCGAGCCCTTCAGCCTCTCAATCAGCGCATGGTCTTTGCTTCTTTCATCCAAGCAGGATCCTCGTATACCACAGGTG
AAATGCTGAGTCTAGGTGTAGGAATCTTGGTTGGCTGTCTCTGCCTTCTCCTGGCTGTTTATTTCATTGCTAGAAAGATTCGGAAGAAGA
GGCTGGAAAACCGAAAGAGTGTGGTCTTCACCTCAGCACAAGCCACGACTGAGGCATAAATTCCTTCTCAGATACCATGGATGTGGATGA
CTTCCCTTCATGCCTATCAGGAAGCCTCTAAAATGGGGTGTAGGATCTGGCCAGAAACACTGTAGGAGTAGTAAGCAGATGTCCTCCTTC
CCCTGGACATCTCCTAGAGAGGAATGGACCCAGGCTGTCATTCCAGGAAGAACTGCAGAGCCTTCAGCCTCTCCAAACATGTAGGAGGAA
ATGAGGAAATCGCTGTGTTGTTAATGCAGAGAACAAACTCTGTTTAGTTGCAGGGGAAGTTTGGGATATACCCCAAAGTCCTCTACCCCC
TCACTTTTATGGCCCTTTCCCTAGATATACTGCGGGATCTCTCCTTAGGATAAAGAGTTGCTGTTGAAGTTGTATATTTTTGATCAATAT

>77255_77255_5_RPRD2-CA14_RPRD2_chr1_150337395_ENST00000401000_CA14_chr1_150232546_ENST00000369111_length(amino acids)=387AA_BP=69
MAAGGGGGSSKASSSSASSAGALESSLDRKFQSVTNTMESIQGLSSWCIENKKHHSTIVYHWMKWLRRCQHWTYEGPHGQDHWPASYPEC
GNNAQSPIDIQTDSVTFDPDLPALQPHGYDQPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGGSEHQINSEAT
FAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSHLHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPP
CYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGEMLSLGVGILVGCLCLLLAVYF

--------------------------------------------------------------
>77255_77255_6_RPRD2-CA14_RPRD2_chr1_150337395_ENST00000401000_CA14_chr1_150236993_ENST00000369111_length(transcript)=756nt_BP=270nt
CCGCTCCCGCCGCCGCCGCCGCCGCCGCCGCCAGAGGAGCAGCAGCGCTTGTGCAAACCGGGAAGATGGCGGCCGGCGGCGGCGGAGGCA
GCAGTAAGGCCTCCTCCTCGTCGGCCTCTTCGGCAGGGGCTCTGGAGTCCTCGTTGGATCGAAAATTCCAGTCGGTAACCAACACCATGG
AGTCCATTCAAGGCTTGTCGTCTTGGTGTATAGAGAACAAAAAACACCACAGTACTATCGTCTATCATTGGATGAAGTGGCTCCGGAGAT
GAAGAAGAGGCTGGAAAACCGAAAGAGTGTGGTCTTCACCTCAGCACAAGCCACGACTGAGGCATAAATTCCTTCTCAGATACCATGGAT
GTGGATGACTTCCCTTCATGCCTATCAGGAAGCCTCTAAAATGGGGTGTAGGATCTGGCCAGAAACACTGTAGGAGTAGTAAGCAGATGT
CCTCCTTCCCCTGGACATCTCCTAGAGAGGAATGGACCCAGGCTGTCATTCCAGGAAGAACTGCAGAGCCTTCAGCCTCTCCAAACATGT
AGGAGGAAATGAGGAAATCGCTGTGTTGTTAATGCAGAGAACAAACTCTGTTTAGTTGCAGGGGAAGTTTGGGATATACCCCAAAGTCCT
CTACCCCCTCACTTTTATGGCCCTTTCCCTAGATATACTGCGGGATCTCTCCTTAGGATAAAGAGTTGCTGTTGAAGTTGTATATTTTTG

>77255_77255_6_RPRD2-CA14_RPRD2_chr1_150337395_ENST00000401000_CA14_chr1_150236993_ENST00000369111_length(amino acids)=82AA_BP=

--------------------------------------------------------------
>77255_77255_7_RPRD2-CA14_RPRD2_chr1_150337395_ENST00000539519_CA14_chr1_150232546_ENST00000369111_length(transcript)=1605nt_BP=227nt
AGCGCTTGTGCAAACCGGGAAGATGGCGGCCGGCGGCGGCGGAGGCAGCAGTAAGGCCTCCTCCTCGTCGGCCTCTTCGGCAGGGGCTCT
GGAGTCCTCGTTGGATCGAAAATTCCAGTCGGTAACCAACACCATGGAGTCCATTCAAGGCTTGTCGTCTTGGTGTATAGAGAACAAAAA
ACACCACAGTACTATCGTCTATCATTGGATGAAGTGGCTCCGGAGATGTCAACACTGGACGTATGAGGGCCCACATGGTCAGGACCATTG
GCCAGCCTCTTACCCTGAGTGTGGAAACAATGCCCAGTCGCCCATCGATATTCAGACAGACAGTGTGACATTTGACCCTGATTTGCCTGC
TCTGCAGCCCCACGGATATGACCAGCCTGGCACCGAGCCTTTGGACCTGCACAACAATGGCCACACAGTGCAACTCTCTCTGCCCTCTAC
CCTGTATCTGGGTGGACTTCCCCGAAAATATGTAGCTGCCCAGCTCCACCTGCACTGGGGTCAGAAAGGATCCCCAGGGGGGTCAGAACA
CCAGATCAACAGTGAAGCCACATTTGCAGAGCTCCACATTGTACATTATGACTCTGATTCCTATGACAGCTTGAGTGAGGCTGCTGAGAG
GCCTCAGGGCCTGGCTGTCCTGGGCATCCTAATTGAGGTGGGTGAGACTAAGAATATAGCTTATGAACACATTCTGAGTCACTTGCATGA
AGTCAGGCATAAAGATCAGAAGACCTCAGTGCCTCCCTTCAACCTAAGAGAGCTGCTCCCCAAACAGCTGGGGCAGTACTTCCGCTACAA
TGGCTCGCTCACAACTCCCCCTTGCTACCAGAGTGTGCTCTGGACAGTTTTTTATAGAAGGTCCCAGATTTCAATGGAACAGCTGGAAAA
GCTTCAGGGGACATTGTTCTCCACAGAAGAGGAGCCCTCTAAGCTTCTGGTACAGAACTACCGAGCCCTTCAGCCTCTCAATCAGCGCAT
GGTCTTTGCTTCTTTCATCCAAGCAGGATCCTCGTATACCACAGGTGAAATGCTGAGTCTAGGTGTAGGAATCTTGGTTGGCTGTCTCTG
CCTTCTCCTGGCTGTTTATTTCATTGCTAGAAAGATTCGGAAGAAGAGGCTGGAAAACCGAAAGAGTGTGGTCTTCACCTCAGCACAAGC
CACGACTGAGGCATAAATTCCTTCTCAGATACCATGGATGTGGATGACTTCCCTTCATGCCTATCAGGAAGCCTCTAAAATGGGGTGTAG
GATCTGGCCAGAAACACTGTAGGAGTAGTAAGCAGATGTCCTCCTTCCCCTGGACATCTCCTAGAGAGGAATGGACCCAGGCTGTCATTC
CAGGAAGAACTGCAGAGCCTTCAGCCTCTCCAAACATGTAGGAGGAAATGAGGAAATCGCTGTGTTGTTAATGCAGAGAACAAACTCTGT
TTAGTTGCAGGGGAAGTTTGGGATATACCCCAAAGTCCTCTACCCCCTCACTTTTATGGCCCTTTCCCTAGATATACTGCGGGATCTCTC

>77255_77255_7_RPRD2-CA14_RPRD2_chr1_150337395_ENST00000539519_CA14_chr1_150232546_ENST00000369111_length(amino acids)=387AA_BP=69
MAAGGGGGSSKASSSSASSAGALESSLDRKFQSVTNTMESIQGLSSWCIENKKHHSTIVYHWMKWLRRCQHWTYEGPHGQDHWPASYPEC
GNNAQSPIDIQTDSVTFDPDLPALQPHGYDQPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGGSEHQINSEAT
FAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSHLHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPP
CYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGEMLSLGVGILVGCLCLLLAVYF

--------------------------------------------------------------
>77255_77255_8_RPRD2-CA14_RPRD2_chr1_150337395_ENST00000539519_CA14_chr1_150236993_ENST00000369111_length(transcript)=713nt_BP=227nt
AGCGCTTGTGCAAACCGGGAAGATGGCGGCCGGCGGCGGCGGAGGCAGCAGTAAGGCCTCCTCCTCGTCGGCCTCTTCGGCAGGGGCTCT
GGAGTCCTCGTTGGATCGAAAATTCCAGTCGGTAACCAACACCATGGAGTCCATTCAAGGCTTGTCGTCTTGGTGTATAGAGAACAAAAA
ACACCACAGTACTATCGTCTATCATTGGATGAAGTGGCTCCGGAGATGAAGAAGAGGCTGGAAAACCGAAAGAGTGTGGTCTTCACCTCA
GCACAAGCCACGACTGAGGCATAAATTCCTTCTCAGATACCATGGATGTGGATGACTTCCCTTCATGCCTATCAGGAAGCCTCTAAAATG
GGGTGTAGGATCTGGCCAGAAACACTGTAGGAGTAGTAAGCAGATGTCCTCCTTCCCCTGGACATCTCCTAGAGAGGAATGGACCCAGGC
TGTCATTCCAGGAAGAACTGCAGAGCCTTCAGCCTCTCCAAACATGTAGGAGGAAATGAGGAAATCGCTGTGTTGTTAATGCAGAGAACA
AACTCTGTTTAGTTGCAGGGGAAGTTTGGGATATACCCCAAAGTCCTCTACCCCCTCACTTTTATGGCCCTTTCCCTAGATATACTGCGG

>77255_77255_8_RPRD2-CA14_RPRD2_chr1_150337395_ENST00000539519_CA14_chr1_150236993_ENST00000369111_length(amino acids)=75AA_BP=

--------------------------------------------------------------
>77255_77255_9_RPRD2-CA14_RPRD2_chr1_150416853_ENST00000369068_CA14_chr1_150232546_ENST00000369111_length(transcript)=2076nt_BP=698nt
GAAGATGGCGGCCGGCGGCGGCGGAGGCAGCAGTAAGGCCTCCTCCTCGTCGGCCTCTTCGGCAGGGGCTCTGGAGTCCTCGTTGGATCG
AAAATTCCAGTCGGTAACCAACACCATGGAGTCCATTCAAGGCTTGTCGTCTTGGTGTATAGAGAACAAAAAACACCACAGTACTATCGT
CTATCATTGGATGAAGTGGCTCCGGAGATCTGCATATCCCCACCGTTTGAATCTCTTTTACCTTGCCAATGATGTCATACAGAACTGTAA
AAGGAAAAATGCAATCATATTCCGTGAATCATTTGCTGATGTACTTCCTGAAGCAGCTGCTCTAGTGAAGGATCCATCTGTCTCTAAGTC
TGTAGAACGAATCTTTAAAATCTGGGAAGATAGAAATGTATACCCAGAAGAAATGATTGTGGCATTGAGAGAAGCTTTGAGTACCACTTT
CAAAACTCAGAAGCAGCTGAAAGAAAATCTGAACAAACAACCGAATAAGCAGTGGAAGAAATCACAAACATCTACAAATCCAAAAGCTGC
TCTCAAGTCTAAGATAGTTGCTGAATTTCGATCTCAGGCCCTAATTGAAGAGCTGTTGCTATACAAGCGCTCAGAAGATCAGATAGAACT
GAAGGAAAAGCAGTTGTCAACTATGAGGGTGGATGTGTGCAGCACAGAAACTCTCAAATGCTTAAAAGGTCAACACTGGACGTATGAGGG
CCCACATGGTCAGGACCATTGGCCAGCCTCTTACCCTGAGTGTGGAAACAATGCCCAGTCGCCCATCGATATTCAGACAGACAGTGTGAC
ATTTGACCCTGATTTGCCTGCTCTGCAGCCCCACGGATATGACCAGCCTGGCACCGAGCCTTTGGACCTGCACAACAATGGCCACACAGT
GCAACTCTCTCTGCCCTCTACCCTGTATCTGGGTGGACTTCCCCGAAAATATGTAGCTGCCCAGCTCCACCTGCACTGGGGTCAGAAAGG
ATCCCCAGGGGGGTCAGAACACCAGATCAACAGTGAAGCCACATTTGCAGAGCTCCACATTGTACATTATGACTCTGATTCCTATGACAG
CTTGAGTGAGGCTGCTGAGAGGCCTCAGGGCCTGGCTGTCCTGGGCATCCTAATTGAGGTGGGTGAGACTAAGAATATAGCTTATGAACA
CATTCTGAGTCACTTGCATGAAGTCAGGCATAAAGATCAGAAGACCTCAGTGCCTCCCTTCAACCTAAGAGAGCTGCTCCCCAAACAGCT
GGGGCAGTACTTCCGCTACAATGGCTCGCTCACAACTCCCCCTTGCTACCAGAGTGTGCTCTGGACAGTTTTTTATAGAAGGTCCCAGAT
TTCAATGGAACAGCTGGAAAAGCTTCAGGGGACATTGTTCTCCACAGAAGAGGAGCCCTCTAAGCTTCTGGTACAGAACTACCGAGCCCT
TCAGCCTCTCAATCAGCGCATGGTCTTTGCTTCTTTCATCCAAGCAGGATCCTCGTATACCACAGGTGAAATGCTGAGTCTAGGTGTAGG
AATCTTGGTTGGCTGTCTCTGCCTTCTCCTGGCTGTTTATTTCATTGCTAGAAAGATTCGGAAGAAGAGGCTGGAAAACCGAAAGAGTGT
GGTCTTCACCTCAGCACAAGCCACGACTGAGGCATAAATTCCTTCTCAGATACCATGGATGTGGATGACTTCCCTTCATGCCTATCAGGA
AGCCTCTAAAATGGGGTGTAGGATCTGGCCAGAAACACTGTAGGAGTAGTAAGCAGATGTCCTCCTTCCCCTGGACATCTCCTAGAGAGG
AATGGACCCAGGCTGTCATTCCAGGAAGAACTGCAGAGCCTTCAGCCTCTCCAAACATGTAGGAGGAAATGAGGAAATCGCTGTGTTGTT
AATGCAGAGAACAAACTCTGTTTAGTTGCAGGGGAAGTTTGGGATATACCCCAAAGTCCTCTACCCCCTCACTTTTATGGCCCTTTCCCT
AGATATACTGCGGGATCTCTCCTTAGGATAAAGAGTTGCTGTTGAAGTTGTATATTTTTGATCAATATATTTGGAAATTAAAGTTTCTGA

>77255_77255_9_RPRD2-CA14_RPRD2_chr1_150416853_ENST00000369068_CA14_chr1_150232546_ENST00000369111_length(amino acids)=550AA_BP=226
MAAGGGGGSSKASSSSASSAGALESSLDRKFQSVTNTMESIQGLSSWCIENKKHHSTIVYHWMKWLRRSAYPHRLNLFYLANDVIQNCKR
KNAIIFRESFADVLPEAAALVKDPSVSKSVERIFKIWEDRNVYPEEMIVALREALSTTFKTQKQLKENLNKQPNKQWKKSQTSTNPKAAL
KSKIVAEFRSQALIEELLLYKRSEDQIELKEKQLSTMRVDVCSTETLKCLKGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTF
DPDLPALQPHGYDQPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGGSEHQINSEATFAELHIVHYDSDSYDSL
SEAAERPQGLAVLGILIEVGETKNIAYEHILSHLHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQIS
MEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGEMLSLGVGILVGCLCLLLAVYFIARKIRKKRLENRKSVV

--------------------------------------------------------------
>77255_77255_10_RPRD2-CA14_RPRD2_chr1_150416853_ENST00000401000_CA14_chr1_150232546_ENST00000369111_length(transcript)=2059nt_BP=681nt
CCGCTCCCGCCGCCGCCGCCGCCGCCGCCGCCAGAGGAGCAGCAGCGCTTGTGCAAACCGGGAAGATGGCGGCCGGCGGCGGCGGAGGCA
GCAGTAAGGCCTCCTCCTCGTCGGCCTCTTCGGCAGGGGCTCTGGAGTCCTCGTTGGATCGAAAATTCCAGTCGGTAACCAACACCATGG
AGTCCATTCAAGGCTTGTCGTCTTGGTGTATAGAGAACAAAAAACACCACAGTACTATCGTCTATCATTGGATGAAGTGGCTCCGGAGAT
CTGCATATCCCCACCGTTTGAATCTCTTTTACCTTGCCAATGATGTCATACAGAACTGTAAAAGGAAAAATGCAATCATATTCCGTGAAT
CATTTGCTGATGTACTTCCTGAAGCAGCTGCTCTAGTGAAGGATCCATCTGTCTCTAAGTCTGTAGAACGAATCTTTAAAATCTGGGAAG
ATAGAAATGTATACCCAGAAGAAATGATTGTGGCATTGAGAGAAGCTTTGACATCTACAAATCCAAAAGCTGCTCTCAAGTCTAAGATAG
TTGCTGAATTTCGATCTCAGGCCCTAATTGAAGAGCTGTTGCTATACAAGCGCTCAGAAGATCAGATAGAACTGAAGGAAAAGCAGTTGT
CAACTATGAGGGTGGATGTGTGCAGCACAGAAACTCTCAAATGCTTAAAAGGTCAACACTGGACGTATGAGGGCCCACATGGTCAGGACC
ATTGGCCAGCCTCTTACCCTGAGTGTGGAAACAATGCCCAGTCGCCCATCGATATTCAGACAGACAGTGTGACATTTGACCCTGATTTGC
CTGCTCTGCAGCCCCACGGATATGACCAGCCTGGCACCGAGCCTTTGGACCTGCACAACAATGGCCACACAGTGCAACTCTCTCTGCCCT
CTACCCTGTATCTGGGTGGACTTCCCCGAAAATATGTAGCTGCCCAGCTCCACCTGCACTGGGGTCAGAAAGGATCCCCAGGGGGGTCAG
AACACCAGATCAACAGTGAAGCCACATTTGCAGAGCTCCACATTGTACATTATGACTCTGATTCCTATGACAGCTTGAGTGAGGCTGCTG
AGAGGCCTCAGGGCCTGGCTGTCCTGGGCATCCTAATTGAGGTGGGTGAGACTAAGAATATAGCTTATGAACACATTCTGAGTCACTTGC
ATGAAGTCAGGCATAAAGATCAGAAGACCTCAGTGCCTCCCTTCAACCTAAGAGAGCTGCTCCCCAAACAGCTGGGGCAGTACTTCCGCT
ACAATGGCTCGCTCACAACTCCCCCTTGCTACCAGAGTGTGCTCTGGACAGTTTTTTATAGAAGGTCCCAGATTTCAATGGAACAGCTGG
AAAAGCTTCAGGGGACATTGTTCTCCACAGAAGAGGAGCCCTCTAAGCTTCTGGTACAGAACTACCGAGCCCTTCAGCCTCTCAATCAGC
GCATGGTCTTTGCTTCTTTCATCCAAGCAGGATCCTCGTATACCACAGGTGAAATGCTGAGTCTAGGTGTAGGAATCTTGGTTGGCTGTC
TCTGCCTTCTCCTGGCTGTTTATTTCATTGCTAGAAAGATTCGGAAGAAGAGGCTGGAAAACCGAAAGAGTGTGGTCTTCACCTCAGCAC
AAGCCACGACTGAGGCATAAATTCCTTCTCAGATACCATGGATGTGGATGACTTCCCTTCATGCCTATCAGGAAGCCTCTAAAATGGGGT
GTAGGATCTGGCCAGAAACACTGTAGGAGTAGTAAGCAGATGTCCTCCTTCCCCTGGACATCTCCTAGAGAGGAATGGACCCAGGCTGTC
ATTCCAGGAAGAACTGCAGAGCCTTCAGCCTCTCCAAACATGTAGGAGGAAATGAGGAAATCGCTGTGTTGTTAATGCAGAGAACAAACT
CTGTTTAGTTGCAGGGGAAGTTTGGGATATACCCCAAAGTCCTCTACCCCCTCACTTTTATGGCCCTTTCCCTAGATATACTGCGGGATC

>77255_77255_10_RPRD2-CA14_RPRD2_chr1_150416853_ENST00000401000_CA14_chr1_150232546_ENST00000369111_length(amino acids)=524AA_BP=200
MAAGGGGGSSKASSSSASSAGALESSLDRKFQSVTNTMESIQGLSSWCIENKKHHSTIVYHWMKWLRRSAYPHRLNLFYLANDVIQNCKR
KNAIIFRESFADVLPEAAALVKDPSVSKSVERIFKIWEDRNVYPEEMIVALREALTSTNPKAALKSKIVAEFRSQALIEELLLYKRSEDQ
IELKEKQLSTMRVDVCSTETLKCLKGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPDLPALQPHGYDQPGTEPLDLHNNG
HTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGGSEHQINSEATFAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIA
YEHILSHLHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNY

--------------------------------------------------------------
>77255_77255_11_RPRD2-CA14_RPRD2_chr1_150416853_ENST00000539519_CA14_chr1_150232546_ENST00000369111_length(transcript)=2016nt_BP=638nt
AGCGCTTGTGCAAACCGGGAAGATGGCGGCCGGCGGCGGCGGAGGCAGCAGTAAGGCCTCCTCCTCGTCGGCCTCTTCGGCAGGGGCTCT
GGAGTCCTCGTTGGATCGAAAATTCCAGTCGGTAACCAACACCATGGAGTCCATTCAAGGCTTGTCGTCTTGGTGTATAGAGAACAAAAA
ACACCACAGTACTATCGTCTATCATTGGATGAAGTGGCTCCGGAGATCTGCATATCCCCACCGTTTGAATCTCTTTTACCTTGCCAATGA
TGTCATACAGAACTGTAAAAGGAAAAATGCAATCATATTCCGTGAATCATTTGCTGATGTACTTCCTGAAGCAGCTGCTCTAGTGAAGGA
TCCATCTGTCTCTAAGTCTGTAGAACGAATCTTTAAAATCTGGGAAGATAGAAATGTATACCCAGAAGAAATGATTGTGGCATTGAGAGA
AGCTTTGACATCTACAAATCCAAAAGCTGCTCTCAAGTCTAAGATAGTTGCTGAATTTCGATCTCAGGCCCTAATTGAAGAGCTGTTGCT
ATACAAGCGCTCAGAAGATCAGATAGAACTGAAGGAAAAGCAGTTGTCAACTATGAGGGTGGATGTGTGCAGCACAGAAACTCTCAAATG
CTTAAAAGGTCAACACTGGACGTATGAGGGCCCACATGGTCAGGACCATTGGCCAGCCTCTTACCCTGAGTGTGGAAACAATGCCCAGTC
GCCCATCGATATTCAGACAGACAGTGTGACATTTGACCCTGATTTGCCTGCTCTGCAGCCCCACGGATATGACCAGCCTGGCACCGAGCC
TTTGGACCTGCACAACAATGGCCACACAGTGCAACTCTCTCTGCCCTCTACCCTGTATCTGGGTGGACTTCCCCGAAAATATGTAGCTGC
CCAGCTCCACCTGCACTGGGGTCAGAAAGGATCCCCAGGGGGGTCAGAACACCAGATCAACAGTGAAGCCACATTTGCAGAGCTCCACAT
TGTACATTATGACTCTGATTCCTATGACAGCTTGAGTGAGGCTGCTGAGAGGCCTCAGGGCCTGGCTGTCCTGGGCATCCTAATTGAGGT
GGGTGAGACTAAGAATATAGCTTATGAACACATTCTGAGTCACTTGCATGAAGTCAGGCATAAAGATCAGAAGACCTCAGTGCCTCCCTT
CAACCTAAGAGAGCTGCTCCCCAAACAGCTGGGGCAGTACTTCCGCTACAATGGCTCGCTCACAACTCCCCCTTGCTACCAGAGTGTGCT
CTGGACAGTTTTTTATAGAAGGTCCCAGATTTCAATGGAACAGCTGGAAAAGCTTCAGGGGACATTGTTCTCCACAGAAGAGGAGCCCTC
TAAGCTTCTGGTACAGAACTACCGAGCCCTTCAGCCTCTCAATCAGCGCATGGTCTTTGCTTCTTTCATCCAAGCAGGATCCTCGTATAC
CACAGGTGAAATGCTGAGTCTAGGTGTAGGAATCTTGGTTGGCTGTCTCTGCCTTCTCCTGGCTGTTTATTTCATTGCTAGAAAGATTCG
GAAGAAGAGGCTGGAAAACCGAAAGAGTGTGGTCTTCACCTCAGCACAAGCCACGACTGAGGCATAAATTCCTTCTCAGATACCATGGAT
GTGGATGACTTCCCTTCATGCCTATCAGGAAGCCTCTAAAATGGGGTGTAGGATCTGGCCAGAAACACTGTAGGAGTAGTAAGCAGATGT
CCTCCTTCCCCTGGACATCTCCTAGAGAGGAATGGACCCAGGCTGTCATTCCAGGAAGAACTGCAGAGCCTTCAGCCTCTCCAAACATGT
AGGAGGAAATGAGGAAATCGCTGTGTTGTTAATGCAGAGAACAAACTCTGTTTAGTTGCAGGGGAAGTTTGGGATATACCCCAAAGTCCT
CTACCCCCTCACTTTTATGGCCCTTTCCCTAGATATACTGCGGGATCTCTCCTTAGGATAAAGAGTTGCTGTTGAAGTTGTATATTTTTG

>77255_77255_11_RPRD2-CA14_RPRD2_chr1_150416853_ENST00000539519_CA14_chr1_150232546_ENST00000369111_length(amino acids)=524AA_BP=200
MAAGGGGGSSKASSSSASSAGALESSLDRKFQSVTNTMESIQGLSSWCIENKKHHSTIVYHWMKWLRRSAYPHRLNLFYLANDVIQNCKR
KNAIIFRESFADVLPEAAALVKDPSVSKSVERIFKIWEDRNVYPEEMIVALREALTSTNPKAALKSKIVAEFRSQALIEELLLYKRSEDQ
IELKEKQLSTMRVDVCSTETLKCLKGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPDLPALQPHGYDQPGTEPLDLHNNG
HTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGGSEHQINSEATFAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIA
YEHILSHLHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNY

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Fusion Gene PPI Analysis for RPRD2-CA14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RPRD2-CA14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RPRD2-CA14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource