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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATP11B-MAP3K13 (FusionGDB2 ID:7733)

Fusion Gene Summary for ATP11B-MAP3K13

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP11B-MAP3K13
Fusion gene ID: 7733
HgeneTgene
Gene symbol

ATP11B

MAP3K13

Gene ID

23200

9175

Gene nameATPase phospholipid transporting 11B (putative)mitogen-activated protein kinase kinase kinase 13
SynonymsATPIF|ATPIRLZK|MEKK13|MLK
Cytomap

3q26.33

3q27.2

Type of geneprotein-codingprotein-coding
Descriptionprobable phospholipid-transporting ATPase IFATPase IRATPase, class VI, type 11BP4-ATPase flippase complex alpha subunit ATP11Btruncated ATPase 11B proteinmitogen-activated protein kinase kinase kinase 13leucine zipper-bearing kinasemixed lineage kinase
Modification date2020031320200313
UniProtAcc

Q9Y2G3

O43283

Ensembl transtripts involved in fusion geneENST00000323116, ENST00000493826, 
ENST00000482794, 		ENST00000265026, 
ENST00000424227, ENST00000438798, 
ENST00000443863, ENST00000446828, 
ENST00000448876, ENST00000454237, 
ENST00000535426, 
Fusion gene scores* DoF score20 X 15 X 10=300012 X 14 X 9=1512
# samples 2214
** MAII scorelog2(22/3000*10)=-3.76938707185858
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/1512*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATP11B [Title/Abstract] AND MAP3K13 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATP11B(182545997)-MAP3K13(185146285), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMAP3K13

GO:0000186

activation of MAPKK activity

11726277

TgeneMAP3K13

GO:0006468

protein phosphorylation

9353328|11726277

TgeneMAP3K13

GO:0007254

JNK cascade

9353328|11726277

TgeneMAP3K13

GO:0046777

protein autophosphorylation

9353328

TgeneMAP3K13

GO:0051092

positive regulation of NF-kappaB transcription factor activity

12492477


check buttonFusion gene breakpoints across ATP11B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MAP3K13 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-DS-A1OC-01AATP11Bchr3

182545997

-MAP3K13chr3

185146285

+
ChimerDB4CESCTCGA-DS-A1OC-01AATP11Bchr3

182545997

+MAP3K13chr3

185146285

+


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Fusion Gene ORF analysis for ATP11B-MAP3K13

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000323116ENST00000265026ATP11Bchr3

182545997

+MAP3K13chr3

185146285

+
5CDS-5UTRENST00000323116ENST00000424227ATP11Bchr3

182545997

+MAP3K13chr3

185146285

+
5CDS-5UTRENST00000493826ENST00000265026ATP11Bchr3

182545997

+MAP3K13chr3

185146285

+
5CDS-5UTRENST00000493826ENST00000424227ATP11Bchr3

182545997

+MAP3K13chr3

185146285

+
5CDS-intronENST00000323116ENST00000438798ATP11Bchr3

182545997

+MAP3K13chr3

185146285

+
5CDS-intronENST00000323116ENST00000443863ATP11Bchr3

182545997

+MAP3K13chr3

185146285

+
5CDS-intronENST00000323116ENST00000446828ATP11Bchr3

182545997

+MAP3K13chr3

185146285

+
5CDS-intronENST00000323116ENST00000448876ATP11Bchr3

182545997

+MAP3K13chr3

185146285

+
5CDS-intronENST00000323116ENST00000454237ATP11Bchr3

182545997

+MAP3K13chr3

185146285

+
5CDS-intronENST00000323116ENST00000535426ATP11Bchr3

182545997

+MAP3K13chr3

185146285

+
5CDS-intronENST00000493826ENST00000438798ATP11Bchr3

182545997

+MAP3K13chr3

185146285

+
5CDS-intronENST00000493826ENST00000443863ATP11Bchr3

182545997

+MAP3K13chr3

185146285

+
5CDS-intronENST00000493826ENST00000446828ATP11Bchr3

182545997

+MAP3K13chr3

185146285

+
5CDS-intronENST00000493826ENST00000448876ATP11Bchr3

182545997

+MAP3K13chr3

185146285

+
5CDS-intronENST00000493826ENST00000454237ATP11Bchr3

182545997

+MAP3K13chr3

185146285

+
5CDS-intronENST00000493826ENST00000535426ATP11Bchr3

182545997

+MAP3K13chr3

185146285

+
intron-5UTRENST00000482794ENST00000265026ATP11Bchr3

182545997

+MAP3K13chr3

185146285

+
intron-5UTRENST00000482794ENST00000424227ATP11Bchr3

182545997

+MAP3K13chr3

185146285

+
intron-intronENST00000482794ENST00000438798ATP11Bchr3

182545997

+MAP3K13chr3

185146285

+
intron-intronENST00000482794ENST00000443863ATP11Bchr3

182545997

+MAP3K13chr3

185146285

+
intron-intronENST00000482794ENST00000446828ATP11Bchr3

182545997

+MAP3K13chr3

185146285

+
intron-intronENST00000482794ENST00000448876ATP11Bchr3

182545997

+MAP3K13chr3

185146285

+
intron-intronENST00000482794ENST00000454237ATP11Bchr3

182545997

+MAP3K13chr3

185146285

+
intron-intronENST00000482794ENST00000535426ATP11Bchr3

182545997

+MAP3K13chr3

185146285

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ATP11B-MAP3K13


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATP11Bchr3182545997+MAP3K13chr3185146284+0.53550.46450007
ATP11Bchr3182545997+MAP3K13chr3185146284+0.53550.46450007

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ATP11B-MAP3K13


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:182545997/:185146285)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP11B

Q9Y2G3

MAP3K13

O43283

FUNCTION: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of intracellular membranes (PubMed:30018401). May contribute to the maintenance of membrane lipid asymmetry in endosome compartment (PubMed:30018401). {ECO:0000269|PubMed:30018401}.FUNCTION: Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. {ECO:0000269|PubMed:11726277, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:9353328}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ATP11B-MAP3K13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ATP11B-MAP3K13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATP11B-MAP3K13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATP11B-MAP3K13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource