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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:RPS13-COBLL1 (FusionGDB2 ID:77361)

Fusion Gene Summary for RPS13-COBLL1

Fusion gene summary

Fusion gene information	Fusion gene name: RPS13-COBLL1
	Fusion gene ID: 77361
		Hgene	Tgene
	Gene symbol	RPS13	COBLL1
	Gene ID	6207	22837
	Gene name	ribosomal protein S13	cordon-bleu WH2 repeat protein like 1
	Synonyms	S13	COBLR1
	Cytomap	11p15.1	2q24.3
	Type of gene	protein-coding	protein-coding
	Description	40S ribosomal protein S13small ribosomal subunit protein uS15	cordon-bleu protein-like 1COBL-like 1
	Modification date	20200327	20200313
	UniProtAcc	.	Q53SF7
	Ensembl transtripts involved in fusion gene	ENST00000228140, ENST00000525634, ENST00000526895,	ENST00000491126, ENST00000194871, ENST00000342193, ENST00000375458, ENST00000392717, ENST00000409184,
Fusion gene scores	* DoF score	16 X 6 X 4=384	4 X 4 X 3=48
	# samples	22	5
	** MAII score	log2(22/384*10)=-0.803602787196497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: RPS13 [Title/Abstract] AND COBLL1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RPS13(17098714)-COBLL1(165542542), # samples:1
Anticipated loss of major functional domain due to fusion event.	RPS13-COBLL1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. RPS13-COBLL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPS13	GO:0033119	negative regulation of RNA splicing	17881366

Fusion gene breakpoints across RPS13 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across COBLL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-CD-A4MG	RPS13	chr11	17098714	-	COBLL1	chr2	165542542	-

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Fusion Gene ORF analysis for RPS13-COBLL1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000228140	ENST00000491126	RPS13	chr11	17098714	-	COBLL1	chr2	165542542	-
5CDS-intron	ENST00000525634	ENST00000491126	RPS13	chr11	17098714	-	COBLL1	chr2	165542542	-
5UTR-3CDS	ENST00000526895	ENST00000194871	RPS13	chr11	17098714	-	COBLL1	chr2	165542542	-
5UTR-3CDS	ENST00000526895	ENST00000342193	RPS13	chr11	17098714	-	COBLL1	chr2	165542542	-
5UTR-3CDS	ENST00000526895	ENST00000375458	RPS13	chr11	17098714	-	COBLL1	chr2	165542542	-
5UTR-3CDS	ENST00000526895	ENST00000392717	RPS13	chr11	17098714	-	COBLL1	chr2	165542542	-
5UTR-3CDS	ENST00000526895	ENST00000409184	RPS13	chr11	17098714	-	COBLL1	chr2	165542542	-
5UTR-intron	ENST00000526895	ENST00000491126	RPS13	chr11	17098714	-	COBLL1	chr2	165542542	-
Frame-shift	ENST00000228140	ENST00000194871	RPS13	chr11	17098714	-	COBLL1	chr2	165542542	-
Frame-shift	ENST00000228140	ENST00000342193	RPS13	chr11	17098714	-	COBLL1	chr2	165542542	-
Frame-shift	ENST00000228140	ENST00000375458	RPS13	chr11	17098714	-	COBLL1	chr2	165542542	-
Frame-shift	ENST00000525634	ENST00000194871	RPS13	chr11	17098714	-	COBLL1	chr2	165542542	-
Frame-shift	ENST00000525634	ENST00000342193	RPS13	chr11	17098714	-	COBLL1	chr2	165542542	-
Frame-shift	ENST00000525634	ENST00000375458	RPS13	chr11	17098714	-	COBLL1	chr2	165542542	-
In-frame	ENST00000228140	ENST00000392717	RPS13	chr11	17098714	-	COBLL1	chr2	165542542	-
In-frame	ENST00000228140	ENST00000409184	RPS13	chr11	17098714	-	COBLL1	chr2	165542542	-
In-frame	ENST00000525634	ENST00000392717	RPS13	chr11	17098714	-	COBLL1	chr2	165542542	-
In-frame	ENST00000525634	ENST00000409184	RPS13	chr11	17098714	-	COBLL1	chr2	165542542	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000228140	RPS13	chr11	17098714	-	ENST00000409184	COBLL1	chr2	165542542	-	1393	176	207	467	86
ENST00000228140	RPS13	chr11	17098714	-	ENST00000392717	COBLL1	chr2	165542542	-	1392	176	207	467	86
ENST00000525634	RPS13	chr11	17098714	-	ENST00000409184	COBLL1	chr2	165542542	-	1514	297	77	364	95
ENST00000525634	RPS13	chr11	17098714	-	ENST00000392717	COBLL1	chr2	165542542	-	1513	297	77	364	95

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000228140	ENST00000409184	RPS13	chr11	17098714	-	COBLL1	chr2	165542542	-	0.4725456	0.52745444
ENST00000228140	ENST00000392717	RPS13	chr11	17098714	-	COBLL1	chr2	165542542	-	0.46720085	0.5327991
ENST00000525634	ENST00000409184	RPS13	chr11	17098714	-	COBLL1	chr2	165542542	-	0.4538076	0.54619235
ENST00000525634	ENST00000392717	RPS13	chr11	17098714	-	COBLL1	chr2	165542542	-	0.45182303	0.54817694

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Fusion Genomic Features for RPS13-COBLL1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RPS13-COBLL1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:17098714/chr2:165542542)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	COBLL1 Q53SF7
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

COBLL1

chr11:17098714

chr2:165542542

ENST00000342193

1081_1101

1138

1167.0

Domain

WH2

Tgene

COBLL1

chr11:17098714

chr2:165542542

ENST00000375458

1081_1101

1100

1129.0

Domain

WH2

Tgene

COBLL1

chr11:17098714

chr2:165542542

ENST00000392717

1081_1101

1176

1205.0

Domain

WH2

Tgene

COBLL1

chr11:17098714

chr2:165542542

ENST00000409184

1081_1101

1138

1167.0

Domain

WH2

Tgene

COBLL1

chr11:17098714

chr2:165542542

ENST00000342193

291_296

1138

1167.0

Motif

Note=KKRRAP 1

Tgene

COBLL1

chr11:17098714

chr2:165542542

ENST00000342193

360_365

1138

1167.0

Motif

Note=KKRRAP 2

Tgene

COBLL1

chr11:17098714

chr2:165542542

ENST00000375458

291_296

1100

1129.0

Motif

Note=KKRRAP 1

Tgene

COBLL1

chr11:17098714

chr2:165542542

ENST00000375458

360_365

1100

1129.0

Motif

Note=KKRRAP 2

Tgene

COBLL1

chr11:17098714

chr2:165542542

ENST00000392717

291_296

1176

1205.0

Motif

Note=KKRRAP 1

Tgene

COBLL1

chr11:17098714

chr2:165542542

ENST00000392717

360_365

1176

1205.0

Motif

Note=KKRRAP 2

Tgene

COBLL1

chr11:17098714

chr2:165542542

ENST00000409184

291_296

1138

1167.0

Motif

Note=KKRRAP 1

Tgene

COBLL1

chr11:17098714

chr2:165542542

ENST00000409184

360_365

1138

1167.0

Motif

Note=KKRRAP 2

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Fusion Gene Sequence for RPS13-COBLL1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>77361_77361_1_RPS13-COBLL1_RPS13_chr11_17098714_ENST00000228140_COBLL1_chr2_165542542_ENST00000392717_length(transcript)=1392nt_BP=176nt
CTTTCGTTGCCTGATCGCCGCCATCATGGGTCGCATGCATGCTCCCGGGAAGGGCCTGTCCCAGTCGGCTTTACCCTATCGACGCAGCGT
CCCCACTTGGTTGAAGTTGACATCTGACGACGTGAAGGAGCAGATTTACAAACTGGCCAAGAAGGGCCTTACTCCTTCACAGATCGGTTA
CCATTCCATCAAATACAATATCTGTGAATGGAAGGTCAAGACTCAGCCATTCCATGTCCCCTGATGCCCAGGACGGCCATTAAATGTTAC
CCTGCCACACCACTGCACTTCACTTCCACTTCAGACCAACTTCATACTAATGGAACATTTTGGCAAATGTATATTCAGATGTACACTAAT
ATATTATCTATTAAAATATTAGAATTTGTGTTGTGGCTTTTAATGCCAGAAGAAAAGTTACCAGAATTTATAATTTATAGTAATTTTTTG
ATCTTTTTTTTGCCTTAAGAGTTGAATATGCTGCTTTAGAACTTTAAAACAAGGTGTAAATGATTTTCATTTTTTACAAATGAAAAATAA
TTCCTTTGTATTGATTTCACTTACCAGCACATTCTCTACAATGGTGACTTAGACAAAAGTATAAGATTCATAGACTTTATATTTGTATGA
CATACAACTAGGACAAACATAGATATGACATTTGCTGCCTCAGTGTAGCAATTGGAAATATTTATAAGTTATATGAAAGCCTGTTTTGGG
CTGAAAGAATGATTTAGAAAACTAGTGATACCAAATAAGTATATTCAGTTCAATAATTATTTTCAATGATGAATCACTTAGTGTGAAAGA
CTTGCCTTGTGTATTCTTTATGTAATTACAAATCACTGTCAATTTTATGGGAAGCTCATAGTATTTTAATATTTTATTAACATGGAACTC
TTGTTTTTTTAATCTTTAGAACTTAAATTCTACAAGAATTTTAAATATTTTCTGTATATAATTATGACATTGTCACACAGAAATTACACA
TTTTATGTGCCAGAAGCCTTAAACATCTTTCTGTGAAAATGCTGATATATTGTGACAGTTATTTCACATTTGATATGTAGAGAGGAATAG
GGGTTAGTTTATGTTTATATTGAAAAACTTTAAAGACTATTTGGAAGTTCCAGAAATTCTGGTTTTAATTCAAGTAAAATGATAAAATAG
TCATTATATAGTTCAGATGCTAATATTCTAAGTAATAATATATATTTACATTGAAGCTAAAACTGTTAAGCAAAACAATGCCCATTTGTC
GGCTTACAGCTCTTCCGGAGTCTAGAGCCTGTTGGTGTTCTGTCCCTACTTTAAGAATTTAATTGCTCACTTATTCTGAAAGCTTTGTTC

>77361_77361_1_RPS13-COBLL1_RPS13_chr11_17098714_ENST00000228140_COBLL1_chr2_165542542_ENST00000392717_length(amino acids)=86AA_BP=

--------------------------------------------------------------
>77361_77361_2_RPS13-COBLL1_RPS13_chr11_17098714_ENST00000228140_COBLL1_chr2_165542542_ENST00000409184_length(transcript)=1393nt_BP=176nt
CTTTCGTTGCCTGATCGCCGCCATCATGGGTCGCATGCATGCTCCCGGGAAGGGCCTGTCCCAGTCGGCTTTACCCTATCGACGCAGCGT
CCCCACTTGGTTGAAGTTGACATCTGACGACGTGAAGGAGCAGATTTACAAACTGGCCAAGAAGGGCCTTACTCCTTCACAGATCGGTTA
CCATTCCATCAAATACAATATCTGTGAATGGAAGGTCAAGACTCAGCCATTCCATGTCCCCTGATGCCCAGGACGGCCATTAAATGTTAC
CCTGCCACACCACTGCACTTCACTTCCACTTCAGACCAACTTCATACTAATGGAACATTTTGGCAAATGTATATTCAGATGTACACTAAT
ATATTATCTATTAAAATATTAGAATTTGTGTTGTGGCTTTTAATGCCAGAAGAAAAGTTACCAGAATTTATAATTTATAGTAATTTTTTG
ATCTTTTTTTTGCCTTAAGAGTTGAATATGCTGCTTTAGAACTTTAAAACAAGGTGTAAATGATTTTCATTTTTTACAAATGAAAAATAA
TTCCTTTGTATTGATTTCACTTACCAGCACATTCTCTACAATGGTGACTTAGACAAAAGTATAAGATTCATAGACTTTATATTTGTATGA
CATACAACTAGGACAAACATAGATATGACATTTGCTGCCTCAGTGTAGCAATTGGAAATATTTATAAGTTATATGAAAGCCTGTTTTGGG
CTGAAAGAATGATTTAGAAAACTAGTGATACCAAATAAGTATATTCAGTTCAATAATTATTTTCAATGATGAATCACTTAGTGTGAAAGA
CTTGCCTTGTGTATTCTTTATGTAATTACAAATCACTGTCAATTTTATGGGAAGCTCATAGTATTTTAATATTTTATTAACATGGAACTC
TTGTTTTTTTAATCTTTAGAACTTAAATTCTACAAGAATTTTAAATATTTTCTGTATATAATTATGACATTGTCACACAGAAATTACACA
TTTTATGTGCCAGAAGCCTTAAACATCTTTCTGTGAAAATGCTGATATATTGTGACAGTTATTTCACATTTGATATGTAGAGAGGAATAG
GGGTTAGTTTATGTTTATATTGAAAAACTTTAAAGACTATTTGGAAGTTCCAGAAATTCTGGTTTTAATTCAAGTAAAATGATAAAATAG
TCATTATATAGTTCAGATGCTAATATTCTAAGTAATAATATATATTTACATTGAAGCTAAAACTGTTAAGCAAAACAATGCCCATTTGTC
GGCTTACAGCTCTTCCGGAGTCTAGAGCCTGTTGGTGTTCTGTCCCTACTTTAAGAATTTAATTGCTCACTTATTCTGAAAGCTTTGTTC

>77361_77361_2_RPS13-COBLL1_RPS13_chr11_17098714_ENST00000228140_COBLL1_chr2_165542542_ENST00000409184_length(amino acids)=86AA_BP=

--------------------------------------------------------------
>77361_77361_3_RPS13-COBLL1_RPS13_chr11_17098714_ENST00000525634_COBLL1_chr2_165542542_ENST00000392717_length(transcript)=1513nt_BP=297nt
CACACAGACGGGCGGTGGCTGCGCAGCGTAGCTCCGCCTCCTGCGTGAGAGGAAGCGGGGACGTGTGAGGTCACTTCCTGCGTGTTGGGT
GGCTTCCTGCGGCGTTTCCACTCTCGCTCTCCTTTCGTTGCCTGATCGCCGCCATCATGGGTCGCATGCATGCTCCCGGGAAGGGCCTGT
CCCAGTCGGCTTTACCCTATCGACGCAGCGTCCCCACTTGGTTGAAGTTGACATCTGACGACGTGAAGGAGCAGATTTACAAACTGGCCA
AGAAGGGCCTTACTCCTTCACAGATCGGTTACCATTCCATCAAATACAATATCTGTGAATGGAAGGTCAAGACTCAGCCATTCCATGTCC
CCTGATGCCCAGGACGGCCATTAAATGTTACCCTGCCACACCACTGCACTTCACTTCCACTTCAGACCAACTTCATACTAATGGAACATT
TTGGCAAATGTATATTCAGATGTACACTAATATATTATCTATTAAAATATTAGAATTTGTGTTGTGGCTTTTAATGCCAGAAGAAAAGTT
ACCAGAATTTATAATTTATAGTAATTTTTTGATCTTTTTTTTGCCTTAAGAGTTGAATATGCTGCTTTAGAACTTTAAAACAAGGTGTAA
ATGATTTTCATTTTTTACAAATGAAAAATAATTCCTTTGTATTGATTTCACTTACCAGCACATTCTCTACAATGGTGACTTAGACAAAAG
TATAAGATTCATAGACTTTATATTTGTATGACATACAACTAGGACAAACATAGATATGACATTTGCTGCCTCAGTGTAGCAATTGGAAAT
ATTTATAAGTTATATGAAAGCCTGTTTTGGGCTGAAAGAATGATTTAGAAAACTAGTGATACCAAATAAGTATATTCAGTTCAATAATTA
TTTTCAATGATGAATCACTTAGTGTGAAAGACTTGCCTTGTGTATTCTTTATGTAATTACAAATCACTGTCAATTTTATGGGAAGCTCAT
AGTATTTTAATATTTTATTAACATGGAACTCTTGTTTTTTTAATCTTTAGAACTTAAATTCTACAAGAATTTTAAATATTTTCTGTATAT
AATTATGACATTGTCACACAGAAATTACACATTTTATGTGCCAGAAGCCTTAAACATCTTTCTGTGAAAATGCTGATATATTGTGACAGT
TATTTCACATTTGATATGTAGAGAGGAATAGGGGTTAGTTTATGTTTATATTGAAAAACTTTAAAGACTATTTGGAAGTTCCAGAAATTC
TGGTTTTAATTCAAGTAAAATGATAAAATAGTCATTATATAGTTCAGATGCTAATATTCTAAGTAATAATATATATTTACATTGAAGCTA
AAACTGTTAAGCAAAACAATGCCCATTTGTCGGCTTACAGCTCTTCCGGAGTCTAGAGCCTGTTGGTGTTCTGTCCCTACTTTAAGAATT

>77361_77361_3_RPS13-COBLL1_RPS13_chr11_17098714_ENST00000525634_COBLL1_chr2_165542542_ENST00000392717_length(amino acids)=95AA_BP=73
MRVGWLPAAFPLSLSFRCLIAAIMGRMHAPGKGLSQSALPYRRSVPTWLKLTSDDVKEQIYKLAKKGLTPSQIGYHSIKYNICEWKVKTQ

--------------------------------------------------------------
>77361_77361_4_RPS13-COBLL1_RPS13_chr11_17098714_ENST00000525634_COBLL1_chr2_165542542_ENST00000409184_length(transcript)=1514nt_BP=297nt
CACACAGACGGGCGGTGGCTGCGCAGCGTAGCTCCGCCTCCTGCGTGAGAGGAAGCGGGGACGTGTGAGGTCACTTCCTGCGTGTTGGGT
GGCTTCCTGCGGCGTTTCCACTCTCGCTCTCCTTTCGTTGCCTGATCGCCGCCATCATGGGTCGCATGCATGCTCCCGGGAAGGGCCTGT
CCCAGTCGGCTTTACCCTATCGACGCAGCGTCCCCACTTGGTTGAAGTTGACATCTGACGACGTGAAGGAGCAGATTTACAAACTGGCCA
AGAAGGGCCTTACTCCTTCACAGATCGGTTACCATTCCATCAAATACAATATCTGTGAATGGAAGGTCAAGACTCAGCCATTCCATGTCC
CCTGATGCCCAGGACGGCCATTAAATGTTACCCTGCCACACCACTGCACTTCACTTCCACTTCAGACCAACTTCATACTAATGGAACATT
TTGGCAAATGTATATTCAGATGTACACTAATATATTATCTATTAAAATATTAGAATTTGTGTTGTGGCTTTTAATGCCAGAAGAAAAGTT
ACCAGAATTTATAATTTATAGTAATTTTTTGATCTTTTTTTTGCCTTAAGAGTTGAATATGCTGCTTTAGAACTTTAAAACAAGGTGTAA
ATGATTTTCATTTTTTACAAATGAAAAATAATTCCTTTGTATTGATTTCACTTACCAGCACATTCTCTACAATGGTGACTTAGACAAAAG
TATAAGATTCATAGACTTTATATTTGTATGACATACAACTAGGACAAACATAGATATGACATTTGCTGCCTCAGTGTAGCAATTGGAAAT
ATTTATAAGTTATATGAAAGCCTGTTTTGGGCTGAAAGAATGATTTAGAAAACTAGTGATACCAAATAAGTATATTCAGTTCAATAATTA
TTTTCAATGATGAATCACTTAGTGTGAAAGACTTGCCTTGTGTATTCTTTATGTAATTACAAATCACTGTCAATTTTATGGGAAGCTCAT
AGTATTTTAATATTTTATTAACATGGAACTCTTGTTTTTTTAATCTTTAGAACTTAAATTCTACAAGAATTTTAAATATTTTCTGTATAT
AATTATGACATTGTCACACAGAAATTACACATTTTATGTGCCAGAAGCCTTAAACATCTTTCTGTGAAAATGCTGATATATTGTGACAGT
TATTTCACATTTGATATGTAGAGAGGAATAGGGGTTAGTTTATGTTTATATTGAAAAACTTTAAAGACTATTTGGAAGTTCCAGAAATTC
TGGTTTTAATTCAAGTAAAATGATAAAATAGTCATTATATAGTTCAGATGCTAATATTCTAAGTAATAATATATATTTACATTGAAGCTA
AAACTGTTAAGCAAAACAATGCCCATTTGTCGGCTTACAGCTCTTCCGGAGTCTAGAGCCTGTTGGTGTTCTGTCCCTACTTTAAGAATT

>77361_77361_4_RPS13-COBLL1_RPS13_chr11_17098714_ENST00000525634_COBLL1_chr2_165542542_ENST00000409184_length(amino acids)=95AA_BP=73
MRVGWLPAAFPLSLSFRCLIAAIMGRMHAPGKGLSQSALPYRRSVPTWLKLTSDDVKEQIYKLAKKGLTPSQIGYHSIKYNICEWKVKTQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RPS13-COBLL1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for RPS13-COBLL1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for RPS13-COBLL1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source