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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RPS3-ZNF536 (FusionGDB2 ID:77917)

Fusion Gene Summary for RPS3-ZNF536

check button Fusion gene summary
Fusion gene informationFusion gene name: RPS3-ZNF536
Fusion gene ID: 77917
HgeneTgene
Gene symbol

RPS3

ZNF536

Gene ID

6188

9745

Gene nameribosomal protein S3zinc finger protein 536
SynonymsS3-
Cytomap

11q13.4

19q12

Type of geneprotein-codingprotein-coding
Description40S ribosomal protein S3IMR-90 ribosomal protein S3small ribosomal subunit protein uS3zinc finger protein 536
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000278572, ENST00000524851, 
ENST00000526608, ENST00000527446, 
ENST00000531188, ENST00000529285, 
ENST00000530164, ENST00000534440, 
ENST00000590564, ENST00000355537, 
Fusion gene scores* DoF score17 X 19 X 5=161521 X 13 X 13=3549
# samples 2225
** MAII scorelog2(22/1615*10)=-2.87595873605663
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(25/3549*10)=-3.82741257439886
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPS3 [Title/Abstract] AND ZNF536 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRPS3(75115227)-ZNF536(31039220), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPS3

GO:0006979

response to oxidative stress

23911537

HgeneRPS3

GO:0017148

negative regulation of translation

20217897

HgeneRPS3

GO:0031397

negative regulation of protein ubiquitination

19656744

HgeneRPS3

GO:0032079

positive regulation of endodeoxyribonuclease activity

18973764

HgeneRPS3

GO:0042769

DNA damage response, detection of DNA damage

23911537

HgeneRPS3

GO:0045739

positive regulation of DNA repair

23911537

HgeneRPS3

GO:0061481

response to TNF agonist

20041225

HgeneRPS3

GO:0070301

cellular response to hydrogen peroxide

23911537

HgeneRPS3

GO:1901224

positive regulation of NIK/NF-kappaB signaling

20041225

HgeneRPS3

GO:1902546

positive regulation of DNA N-glycosylase activity

15518571

HgeneRPS3

GO:1905053

positive regulation of base-excision repair

18973764

HgeneRPS3

GO:2001235

positive regulation of apoptotic signaling pathway

14988002

TgeneZNF536

GO:0000122

negative regulation of transcription by RNA polymerase II

19398580


check buttonFusion gene breakpoints across RPS3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZNF536 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4READTCGA-AG-3582RPS3chr11

75115227

+ZNF536chr19

31039220

+


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Fusion Gene ORF analysis for RPS3-ZNF536

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000278572ENST00000590564RPS3chr11

75115227

+ZNF536chr19

31039220

+
5CDS-intronENST00000524851ENST00000590564RPS3chr11

75115227

+ZNF536chr19

31039220

+
5CDS-intronENST00000526608ENST00000590564RPS3chr11

75115227

+ZNF536chr19

31039220

+
5CDS-intronENST00000527446ENST00000590564RPS3chr11

75115227

+ZNF536chr19

31039220

+
5CDS-intronENST00000531188ENST00000590564RPS3chr11

75115227

+ZNF536chr19

31039220

+
In-frameENST00000278572ENST00000355537RPS3chr11

75115227

+ZNF536chr19

31039220

+
In-frameENST00000524851ENST00000355537RPS3chr11

75115227

+ZNF536chr19

31039220

+
In-frameENST00000526608ENST00000355537RPS3chr11

75115227

+ZNF536chr19

31039220

+
In-frameENST00000527446ENST00000355537RPS3chr11

75115227

+ZNF536chr19

31039220

+
In-frameENST00000531188ENST00000355537RPS3chr11

75115227

+ZNF536chr19

31039220

+
intron-3CDSENST00000529285ENST00000355537RPS3chr11

75115227

+ZNF536chr19

31039220

+
intron-3CDSENST00000530164ENST00000355537RPS3chr11

75115227

+ZNF536chr19

31039220

+
intron-3CDSENST00000534440ENST00000355537RPS3chr11

75115227

+ZNF536chr19

31039220

+
intron-intronENST00000529285ENST00000590564RPS3chr11

75115227

+ZNF536chr19

31039220

+
intron-intronENST00000530164ENST00000590564RPS3chr11

75115227

+ZNF536chr19

31039220

+
intron-intronENST00000534440ENST00000590564RPS3chr11

75115227

+ZNF536chr19

31039220

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000531188RPS3chr1175115227+ENST00000355537ZNF536chr1931039220+25404364931644383
ENST00000278572RPS3chr1175115227+ENST00000355537ZNF536chr1931039220+25444404971648383
ENST00000527446RPS3chr1175115227+ENST00000355537ZNF536chr1931039220+24953914481599383
ENST00000526608RPS3chr1175115227+ENST00000355537ZNF536chr1931039220+24533494061557383
ENST00000524851RPS3chr1175115227+ENST00000355537ZNF536chr1931039220+24833794361587383

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000531188ENST00000355537RPS3chr1175115227+ZNF536chr1931039220+0.0011933890.9988066
ENST00000278572ENST00000355537RPS3chr1175115227+ZNF536chr1931039220+0.0010864210.99891365
ENST00000527446ENST00000355537RPS3chr1175115227+ZNF536chr1931039220+0.0012241530.9987758
ENST00000526608ENST00000355537RPS3chr1175115227+ZNF536chr1931039220+0.0011680230.9988319
ENST00000524851ENST00000355537RPS3chr1175115227+ZNF536chr1931039220+0.0012243970.99877554

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Fusion Genomic Features for RPS3-ZNF536


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RPS3-ZNF536


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:75115227/chr19:31039220)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF536chr11:75115227chr19:31039220ENST0000035553705130_15201301.0Zinc fingerC2H2-type 1
TgeneZNF536chr11:75115227chr19:31039220ENST0000035553705158_18001301.0Zinc fingerC2H2-type 2
TgeneZNF536chr11:75115227chr19:31039220ENST0000035553705274_29701301.0Zinc fingerC2H2-type 3
TgeneZNF536chr11:75115227chr19:31039220ENST0000035553705300_32301301.0Zinc fingerC2H2-type 4
TgeneZNF536chr11:75115227chr19:31039220ENST0000035553705345_36701301.0Zinc fingerC2H2-type 5
TgeneZNF536chr11:75115227chr19:31039220ENST0000035553705373_39501301.0Zinc fingerC2H2-type 6
TgeneZNF536chr11:75115227chr19:31039220ENST0000035553705631_65301301.0Zinc fingerC2H2-type 7
TgeneZNF536chr11:75115227chr19:31039220ENST0000035553705751_77301301.0Zinc fingerC2H2-type 8
TgeneZNF536chr11:75115227chr19:31039220ENST0000035553705779_80101301.0Zinc fingerC2H2-type 9

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRPS3chr11:75115227chr19:31039220ENST00000278572+1721_920279.3333333333333DomainKH type-2
HgeneRPS3chr11:75115227chr19:31039220ENST00000524851+1621_920244.0DomainKH type-2
HgeneRPS3chr11:75115227chr19:31039220ENST00000527446+1721_920413.0DomainKH type-2
HgeneRPS3chr11:75115227chr19:31039220ENST00000531188+1721_920646.6666666666666DomainKH type-2


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Fusion Gene Sequence for RPS3-ZNF536


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>77917_77917_1_RPS3-ZNF536_RPS3_chr11_75115227_ENST00000278572_ZNF536_chr19_31039220_ENST00000355537_length(transcript)=2544nt_BP=440nt
GCGGAGCGCGGCGGCAAGATGGCAGTGCAAATATCCAAGAAGAGGAAGTTTGTCGCTGATGGCATCTTCAAAGCTGAACTGAATGAGTTT
CTTACTCGGGAGCTGGCTGAAGATGGCTACTCTGGAGTTGAGGTGCGAGTTACACCAACCAGGACAGAAATCATTATCTTAGCCACCAGA
ACACAGAATGTTCTTGGTGAGAAGGGCCGGCGGATTCGGGAACTGACTGCTGTAGTTCAGAAGAGGTTTGGCTTTCCAGAGGGCAGTGTA
GAGTTGAAAATAATGGTGATGGTAACAGGATATCCCTTGCTTCCTTTAAAGCTTTATGCTGAAAAGGTGGCCACTAGAGGTCTGTGTGCC
ATTGCCCAGGCAGAGTCTCTGCGTTACAAACTCCTAGGAGGGCTTGCTGTGCGGAGTGCGCCACGTGTTGCTCAGACAGGGAGATCGGAA
GAGCTTATCAAAGCATTGTGAGCAACGGTGTGAATTTCCAAGGGTCCTTGCAAGCTTTCATGGACAGTTTTGTCCTCAGTTCCTTGAAGA
AGGAGAAGGACATGAAGGACAAAGCCCTGGCTGACCCCCCTTCCATGAAAGTCCACGGAGTGGATGGTGGTGAGGAGAAACCCAGTGGCA
AGTCCTCCCAGAGGAAGTCCGAGAAATCTCAGTATGAACCCCTGGACTTGTCTGTGCGGCCAGATGCCGCCTCCCTCCCGGGCTCCTCGG
TAACTGTGCAGGACAGCATTGCATGGCACGGCTGCTTGTTTTGTGCTTTCACAACGTCCTCCATGGAGCTCATGGCCCTTCATCTCCAGG
CCAACCACCTGGGCAAAGCGAAACGCAAAGATAACACCATCGGGGTCACAGTCAACTGCAAAGACCAAGCCCGGGAGGCGAGTAAGATGG
CCCTGCTGCCCTCGTTACAATCAAACAAAGACCTGGGCCTCTCCAATATGATCAGCTCTCTAGACTCTGCTTCTGAGAAGATGGCCCAAG
GTCAGCTCAAGGAGACTCTGGGAGAGCAGAAGAGCGGTGCATGGACCGGCCACGTGGACCCTGCATTTTGTAACTTCCCATCAGACTTCT
ACAAGCAGTTTGGTGTTTACCCAGGCATGGTTGGCTCAGGGGCCTCCAGTTCCTGCCCCAACAAGGAGCCTGATGGAAAGGCCCACTCTG
AAGAGGATGTCCCCATCCTGATCCCCGAAACCACGAGTAAGAACACTACTGATGACCTCTCTGACATTGCCTCCTCAGAGGACATGGACT
CCTCCAAGGGGGAGAACAACGATGAAGAGGATGTTGAAACCGAACCGGAAATGATGACCAAGCCACTGTCTGCCCTCAGCAAAGACAGCA
GCAGCGATGGCGGGGACAGCCTGCAGCCCACAGGCACCTCCCAGCCCGTCCAGGGACTGGTCTCACCTTTATCCCAAGCACCGGAGAAGC
AGTGGCACAGCCAGGGTCTTCTCCAAGCCCAGGACCCCTTGGCGGGCCTGCCAAAGCCGGAGCGGGGGCCCCAGAGCCTGGACAAGCCGA
TGAACATGCTGTCGGTCCTCAGGGCCTACAGTTCTGATGGCTTAGCAGCCTTTAACGGACTTGCAAGTAGCACAGCAAATTCTGGATGTA
TCAAGAGGCCAGACTTGTGTGGTAAGTGACACTCCCTGTCCTAGTCGGTCTATCTGGACTTGCCCTTGTCTGTTCGTGGTCCTCGGTGGT
TATCTGCAGCTTGTTAATCGTGTAAAGTCAAGAGAAGAATGTATACACATATGTGTGTTGAATAATTACTATTGGCATAGGTATGTGTAT
ACACACGGTGCACCAATCTACAGTATATATAGCAGAGAATCAGAGGCTAAAAATATTACCCCATATGTTCCAGTATTAGTCATGGATTGC
AAAGGCTTAGTAACTTGAGCAGGAGAGAAAACTCCCTCAAAGTCATAAATCCTGAGTGACAACTGCTGCTGGATGACAGATCCCTTCACC
TGTGGACAACCTGGCTGGGGGTGGGGGGCTGTTCCACCAGCTCACCTGAGCATGTAGAGGTGGGTCCTGCAGTGGTCTCGTGGGTATTAC
TGCTTGTGTCTGATTGTCCTGTATTTTGTAACACTTTAGAAGAATACAGAAAAGTGCAGTAATTCTCTTTCTCCATAGTATTTAAGCAGA
AATATTGCTAGTTTAATATTGTGTCAGGTCGTCCTATTAACCAGGAGCAGATGACAGTAAAATTTCAGTGAATAGCACCTTGACATCTAC
AACTTAAAAATGGTGATTGAAGCAAAATATGTAAACTTGTACGGGGTGATCGTGTGCTTTGGAACAGAGTATTGTTGAAGTAATTAGAAG
ATATATTAAGGTGTTCCTGGTAATGAAGGCATGTAAGTTATAATAATTGTAGCTTTCTGAATAAGTGTCAAACTATATCTTTAAGTGTGC
TGTATGCTGAGTTACAAGTTAGGTCATTTATGAATGGAATGTAAAATAATACTAAAAATGCTTCAATAACTTATCTTGGTATTGCTAATA

>77917_77917_1_RPS3-ZNF536_RPS3_chr11_75115227_ENST00000278572_ZNF536_chr19_31039220_ENST00000355537_length(amino acids)=383AA_BP=
MQAFMDSFVLSSLKKEKDMKDKALADPPSMKVHGVDGGEEKPSGKSSQRKSEKSQYEPLDLSVRPDAASLPGSSVTVQDSIAWHGCLFCA
FTTSSMELMALHLQANHLGKAKRKDNTIGVTVNCKDQAREASKMALLPSLQSNKDLGLSNMISSLDSASEKMAQGQLKETLGEQKSGAWT
GHVDPAFCNFPSDFYKQFGVYPGMVGSGASSSCPNKEPDGKAHSEEDVPILIPETTSKNTTDDLSDIASSEDMDSSKGENNDEEDVETEP
EMMTKPLSALSKDSSSDGGDSLQPTGTSQPVQGLVSPLSQAPEKQWHSQGLLQAQDPLAGLPKPERGPQSLDKPMNMLSVLRAYSSDGLA

--------------------------------------------------------------
>77917_77917_2_RPS3-ZNF536_RPS3_chr11_75115227_ENST00000524851_ZNF536_chr19_31039220_ENST00000355537_length(transcript)=2483nt_BP=379nt
GCAAGATGGCAGTGCAAATATCCAAGAAGAGGAAGTTTGTCGCTGATGGCATCTTCAAAGCTGAACTGAATGAGTTTCTTACTCGGGAGC
TGGCTGAAGATGGCTACTCTGGAGTTGAGGTGCGAGTTACACCAACCAGGACAGAAATCATTATCTTAGCCACCAGAACACAGAATGTTC
TTGGTGAGAAGGGCCGGCGGATTCGGGAACTGACTGCTGTAGTTCAGAAGAGGTTTGGCTTTCCAGAGGGCAGTGTAGAGCTTTATGCTG
AAAAGGTGGCCACTAGAGGTCTGTGTGCCATTGCCCAGGCAGAGTCTCTGCGTTACAAACTCCTAGGAGGGCTTGCTGTGCGGAGTGCGC
CACGTGTTGCTCAGACAGGGAGATCGGAAGAGCTTATCAAAGCATTGTGAGCAACGGTGTGAATTTCCAAGGGTCCTTGCAAGCTTTCAT
GGACAGTTTTGTCCTCAGTTCCTTGAAGAAGGAGAAGGACATGAAGGACAAAGCCCTGGCTGACCCCCCTTCCATGAAAGTCCACGGAGT
GGATGGTGGTGAGGAGAAACCCAGTGGCAAGTCCTCCCAGAGGAAGTCCGAGAAATCTCAGTATGAACCCCTGGACTTGTCTGTGCGGCC
AGATGCCGCCTCCCTCCCGGGCTCCTCGGTAACTGTGCAGGACAGCATTGCATGGCACGGCTGCTTGTTTTGTGCTTTCACAACGTCCTC
CATGGAGCTCATGGCCCTTCATCTCCAGGCCAACCACCTGGGCAAAGCGAAACGCAAAGATAACACCATCGGGGTCACAGTCAACTGCAA
AGACCAAGCCCGGGAGGCGAGTAAGATGGCCCTGCTGCCCTCGTTACAATCAAACAAAGACCTGGGCCTCTCCAATATGATCAGCTCTCT
AGACTCTGCTTCTGAGAAGATGGCCCAAGGTCAGCTCAAGGAGACTCTGGGAGAGCAGAAGAGCGGTGCATGGACCGGCCACGTGGACCC
TGCATTTTGTAACTTCCCATCAGACTTCTACAAGCAGTTTGGTGTTTACCCAGGCATGGTTGGCTCAGGGGCCTCCAGTTCCTGCCCCAA
CAAGGAGCCTGATGGAAAGGCCCACTCTGAAGAGGATGTCCCCATCCTGATCCCCGAAACCACGAGTAAGAACACTACTGATGACCTCTC
TGACATTGCCTCCTCAGAGGACATGGACTCCTCCAAGGGGGAGAACAACGATGAAGAGGATGTTGAAACCGAACCGGAAATGATGACCAA
GCCACTGTCTGCCCTCAGCAAAGACAGCAGCAGCGATGGCGGGGACAGCCTGCAGCCCACAGGCACCTCCCAGCCCGTCCAGGGACTGGT
CTCACCTTTATCCCAAGCACCGGAGAAGCAGTGGCACAGCCAGGGTCTTCTCCAAGCCCAGGACCCCTTGGCGGGCCTGCCAAAGCCGGA
GCGGGGGCCCCAGAGCCTGGACAAGCCGATGAACATGCTGTCGGTCCTCAGGGCCTACAGTTCTGATGGCTTAGCAGCCTTTAACGGACT
TGCAAGTAGCACAGCAAATTCTGGATGTATCAAGAGGCCAGACTTGTGTGGTAAGTGACACTCCCTGTCCTAGTCGGTCTATCTGGACTT
GCCCTTGTCTGTTCGTGGTCCTCGGTGGTTATCTGCAGCTTGTTAATCGTGTAAAGTCAAGAGAAGAATGTATACACATATGTGTGTTGA
ATAATTACTATTGGCATAGGTATGTGTATACACACGGTGCACCAATCTACAGTATATATAGCAGAGAATCAGAGGCTAAAAATATTACCC
CATATGTTCCAGTATTAGTCATGGATTGCAAAGGCTTAGTAACTTGAGCAGGAGAGAAAACTCCCTCAAAGTCATAAATCCTGAGTGACA
ACTGCTGCTGGATGACAGATCCCTTCACCTGTGGACAACCTGGCTGGGGGTGGGGGGCTGTTCCACCAGCTCACCTGAGCATGTAGAGGT
GGGTCCTGCAGTGGTCTCGTGGGTATTACTGCTTGTGTCTGATTGTCCTGTATTTTGTAACACTTTAGAAGAATACAGAAAAGTGCAGTA
ATTCTCTTTCTCCATAGTATTTAAGCAGAAATATTGCTAGTTTAATATTGTGTCAGGTCGTCCTATTAACCAGGAGCAGATGACAGTAAA
ATTTCAGTGAATAGCACCTTGACATCTACAACTTAAAAATGGTGATTGAAGCAAAATATGTAAACTTGTACGGGGTGATCGTGTGCTTTG
GAACAGAGTATTGTTGAAGTAATTAGAAGATATATTAAGGTGTTCCTGGTAATGAAGGCATGTAAGTTATAATAATTGTAGCTTTCTGAA
TAAGTGTCAAACTATATCTTTAAGTGTGCTGTATGCTGAGTTACAAGTTAGGTCATTTATGAATGGAATGTAAAATAATACTAAAAATGC

>77917_77917_2_RPS3-ZNF536_RPS3_chr11_75115227_ENST00000524851_ZNF536_chr19_31039220_ENST00000355537_length(amino acids)=383AA_BP=
MQAFMDSFVLSSLKKEKDMKDKALADPPSMKVHGVDGGEEKPSGKSSQRKSEKSQYEPLDLSVRPDAASLPGSSVTVQDSIAWHGCLFCA
FTTSSMELMALHLQANHLGKAKRKDNTIGVTVNCKDQAREASKMALLPSLQSNKDLGLSNMISSLDSASEKMAQGQLKETLGEQKSGAWT
GHVDPAFCNFPSDFYKQFGVYPGMVGSGASSSCPNKEPDGKAHSEEDVPILIPETTSKNTTDDLSDIASSEDMDSSKGENNDEEDVETEP
EMMTKPLSALSKDSSSDGGDSLQPTGTSQPVQGLVSPLSQAPEKQWHSQGLLQAQDPLAGLPKPERGPQSLDKPMNMLSVLRAYSSDGLA

--------------------------------------------------------------
>77917_77917_3_RPS3-ZNF536_RPS3_chr11_75115227_ENST00000526608_ZNF536_chr19_31039220_ENST00000355537_length(transcript)=2453nt_BP=349nt
GCGGCGGCAAGATGGCAGTGCAAATATCCAAGAAGAGGAAGTTTGTCGCTGATGGCATCTTCAAAGCTGAACTGAATGAGTTTCTTACTC
GGGAGCTGGCTGAAGATGGCTACTCTGGAGTTGAGGTGCGAGTTACACCAACCAGGACAGAAATCATTATCTTAGCCACCAGAACACAGA
ATGTTCTTGGTGAGAAGGGCCGGCGGATTCGGGAACTGACTGCTGTAGTTCAGAAGAGGTTTGGCTTTCCAGAGGGCAGTCTGTGTGCCA
TTGCCCAGGCAGAGTCTCTGCGTTACAAACTCCTAGGAGGGCTTGCTGTGCGGAGTGCGCCACGTGTTGCTCAGACAGGGAGATCGGAAG
AGCTTATCAAAGCATTGTGAGCAACGGTGTGAATTTCCAAGGGTCCTTGCAAGCTTTCATGGACAGTTTTGTCCTCAGTTCCTTGAAGAA
GGAGAAGGACATGAAGGACAAAGCCCTGGCTGACCCCCCTTCCATGAAAGTCCACGGAGTGGATGGTGGTGAGGAGAAACCCAGTGGCAA
GTCCTCCCAGAGGAAGTCCGAGAAATCTCAGTATGAACCCCTGGACTTGTCTGTGCGGCCAGATGCCGCCTCCCTCCCGGGCTCCTCGGT
AACTGTGCAGGACAGCATTGCATGGCACGGCTGCTTGTTTTGTGCTTTCACAACGTCCTCCATGGAGCTCATGGCCCTTCATCTCCAGGC
CAACCACCTGGGCAAAGCGAAACGCAAAGATAACACCATCGGGGTCACAGTCAACTGCAAAGACCAAGCCCGGGAGGCGAGTAAGATGGC
CCTGCTGCCCTCGTTACAATCAAACAAAGACCTGGGCCTCTCCAATATGATCAGCTCTCTAGACTCTGCTTCTGAGAAGATGGCCCAAGG
TCAGCTCAAGGAGACTCTGGGAGAGCAGAAGAGCGGTGCATGGACCGGCCACGTGGACCCTGCATTTTGTAACTTCCCATCAGACTTCTA
CAAGCAGTTTGGTGTTTACCCAGGCATGGTTGGCTCAGGGGCCTCCAGTTCCTGCCCCAACAAGGAGCCTGATGGAAAGGCCCACTCTGA
AGAGGATGTCCCCATCCTGATCCCCGAAACCACGAGTAAGAACACTACTGATGACCTCTCTGACATTGCCTCCTCAGAGGACATGGACTC
CTCCAAGGGGGAGAACAACGATGAAGAGGATGTTGAAACCGAACCGGAAATGATGACCAAGCCACTGTCTGCCCTCAGCAAAGACAGCAG
CAGCGATGGCGGGGACAGCCTGCAGCCCACAGGCACCTCCCAGCCCGTCCAGGGACTGGTCTCACCTTTATCCCAAGCACCGGAGAAGCA
GTGGCACAGCCAGGGTCTTCTCCAAGCCCAGGACCCCTTGGCGGGCCTGCCAAAGCCGGAGCGGGGGCCCCAGAGCCTGGACAAGCCGAT
GAACATGCTGTCGGTCCTCAGGGCCTACAGTTCTGATGGCTTAGCAGCCTTTAACGGACTTGCAAGTAGCACAGCAAATTCTGGATGTAT
CAAGAGGCCAGACTTGTGTGGTAAGTGACACTCCCTGTCCTAGTCGGTCTATCTGGACTTGCCCTTGTCTGTTCGTGGTCCTCGGTGGTT
ATCTGCAGCTTGTTAATCGTGTAAAGTCAAGAGAAGAATGTATACACATATGTGTGTTGAATAATTACTATTGGCATAGGTATGTGTATA
CACACGGTGCACCAATCTACAGTATATATAGCAGAGAATCAGAGGCTAAAAATATTACCCCATATGTTCCAGTATTAGTCATGGATTGCA
AAGGCTTAGTAACTTGAGCAGGAGAGAAAACTCCCTCAAAGTCATAAATCCTGAGTGACAACTGCTGCTGGATGACAGATCCCTTCACCT
GTGGACAACCTGGCTGGGGGTGGGGGGCTGTTCCACCAGCTCACCTGAGCATGTAGAGGTGGGTCCTGCAGTGGTCTCGTGGGTATTACT
GCTTGTGTCTGATTGTCCTGTATTTTGTAACACTTTAGAAGAATACAGAAAAGTGCAGTAATTCTCTTTCTCCATAGTATTTAAGCAGAA
ATATTGCTAGTTTAATATTGTGTCAGGTCGTCCTATTAACCAGGAGCAGATGACAGTAAAATTTCAGTGAATAGCACCTTGACATCTACA
ACTTAAAAATGGTGATTGAAGCAAAATATGTAAACTTGTACGGGGTGATCGTGTGCTTTGGAACAGAGTATTGTTGAAGTAATTAGAAGA
TATATTAAGGTGTTCCTGGTAATGAAGGCATGTAAGTTATAATAATTGTAGCTTTCTGAATAAGTGTCAAACTATATCTTTAAGTGTGCT
GTATGCTGAGTTACAAGTTAGGTCATTTATGAATGGAATGTAAAATAATACTAAAAATGCTTCAATAACTTATCTTGGTATTGCTAATAA

>77917_77917_3_RPS3-ZNF536_RPS3_chr11_75115227_ENST00000526608_ZNF536_chr19_31039220_ENST00000355537_length(amino acids)=383AA_BP=
MQAFMDSFVLSSLKKEKDMKDKALADPPSMKVHGVDGGEEKPSGKSSQRKSEKSQYEPLDLSVRPDAASLPGSSVTVQDSIAWHGCLFCA
FTTSSMELMALHLQANHLGKAKRKDNTIGVTVNCKDQAREASKMALLPSLQSNKDLGLSNMISSLDSASEKMAQGQLKETLGEQKSGAWT
GHVDPAFCNFPSDFYKQFGVYPGMVGSGASSSCPNKEPDGKAHSEEDVPILIPETTSKNTTDDLSDIASSEDMDSSKGENNDEEDVETEP
EMMTKPLSALSKDSSSDGGDSLQPTGTSQPVQGLVSPLSQAPEKQWHSQGLLQAQDPLAGLPKPERGPQSLDKPMNMLSVLRAYSSDGLA

--------------------------------------------------------------
>77917_77917_4_RPS3-ZNF536_RPS3_chr11_75115227_ENST00000527446_ZNF536_chr19_31039220_ENST00000355537_length(transcript)=2495nt_BP=391nt
CGGAGCGCGGCGGCAAGATGGCAGTGCAAATATCCAAGAAGAGGAAGTTTGTCGCTGATGGCATCTTCAAAGCTGAACTGAATGAGTTTC
TTACTCGGGAGCTGGCTGAAGATGGCTACTCTGGAGTTGAGGTGCGAGTTACACCAACCAGGACAGAAATCATTATCTTAGCCACCAGAA
CACAGAATGTTCTTGGTGAGAAGGGCCGGCGGATTCGGGAACTGACTGCTGTAGTTCAGAAGAGGTTTGGCTTTCCAGAGGGCAGTGTAG
AGCTTTATGCTGAAAAGGTGGCCACTAGAGGTCTGTGTGCCATTGCCCAGGCAGAGTCTCTGCGTTACAAACTCCTAGGAGGGCTTGCTG
TGCGGAGTGCGCCACGTGTTGCTCAGACAGGGAGATCGGAAGAGCTTATCAAAGCATTGTGAGCAACGGTGTGAATTTCCAAGGGTCCTT
GCAAGCTTTCATGGACAGTTTTGTCCTCAGTTCCTTGAAGAAGGAGAAGGACATGAAGGACAAAGCCCTGGCTGACCCCCCTTCCATGAA
AGTCCACGGAGTGGATGGTGGTGAGGAGAAACCCAGTGGCAAGTCCTCCCAGAGGAAGTCCGAGAAATCTCAGTATGAACCCCTGGACTT
GTCTGTGCGGCCAGATGCCGCCTCCCTCCCGGGCTCCTCGGTAACTGTGCAGGACAGCATTGCATGGCACGGCTGCTTGTTTTGTGCTTT
CACAACGTCCTCCATGGAGCTCATGGCCCTTCATCTCCAGGCCAACCACCTGGGCAAAGCGAAACGCAAAGATAACACCATCGGGGTCAC
AGTCAACTGCAAAGACCAAGCCCGGGAGGCGAGTAAGATGGCCCTGCTGCCCTCGTTACAATCAAACAAAGACCTGGGCCTCTCCAATAT
GATCAGCTCTCTAGACTCTGCTTCTGAGAAGATGGCCCAAGGTCAGCTCAAGGAGACTCTGGGAGAGCAGAAGAGCGGTGCATGGACCGG
CCACGTGGACCCTGCATTTTGTAACTTCCCATCAGACTTCTACAAGCAGTTTGGTGTTTACCCAGGCATGGTTGGCTCAGGGGCCTCCAG
TTCCTGCCCCAACAAGGAGCCTGATGGAAAGGCCCACTCTGAAGAGGATGTCCCCATCCTGATCCCCGAAACCACGAGTAAGAACACTAC
TGATGACCTCTCTGACATTGCCTCCTCAGAGGACATGGACTCCTCCAAGGGGGAGAACAACGATGAAGAGGATGTTGAAACCGAACCGGA
AATGATGACCAAGCCACTGTCTGCCCTCAGCAAAGACAGCAGCAGCGATGGCGGGGACAGCCTGCAGCCCACAGGCACCTCCCAGCCCGT
CCAGGGACTGGTCTCACCTTTATCCCAAGCACCGGAGAAGCAGTGGCACAGCCAGGGTCTTCTCCAAGCCCAGGACCCCTTGGCGGGCCT
GCCAAAGCCGGAGCGGGGGCCCCAGAGCCTGGACAAGCCGATGAACATGCTGTCGGTCCTCAGGGCCTACAGTTCTGATGGCTTAGCAGC
CTTTAACGGACTTGCAAGTAGCACAGCAAATTCTGGATGTATCAAGAGGCCAGACTTGTGTGGTAAGTGACACTCCCTGTCCTAGTCGGT
CTATCTGGACTTGCCCTTGTCTGTTCGTGGTCCTCGGTGGTTATCTGCAGCTTGTTAATCGTGTAAAGTCAAGAGAAGAATGTATACACA
TATGTGTGTTGAATAATTACTATTGGCATAGGTATGTGTATACACACGGTGCACCAATCTACAGTATATATAGCAGAGAATCAGAGGCTA
AAAATATTACCCCATATGTTCCAGTATTAGTCATGGATTGCAAAGGCTTAGTAACTTGAGCAGGAGAGAAAACTCCCTCAAAGTCATAAA
TCCTGAGTGACAACTGCTGCTGGATGACAGATCCCTTCACCTGTGGACAACCTGGCTGGGGGTGGGGGGCTGTTCCACCAGCTCACCTGA
GCATGTAGAGGTGGGTCCTGCAGTGGTCTCGTGGGTATTACTGCTTGTGTCTGATTGTCCTGTATTTTGTAACACTTTAGAAGAATACAG
AAAAGTGCAGTAATTCTCTTTCTCCATAGTATTTAAGCAGAAATATTGCTAGTTTAATATTGTGTCAGGTCGTCCTATTAACCAGGAGCA
GATGACAGTAAAATTTCAGTGAATAGCACCTTGACATCTACAACTTAAAAATGGTGATTGAAGCAAAATATGTAAACTTGTACGGGGTGA
TCGTGTGCTTTGGAACAGAGTATTGTTGAAGTAATTAGAAGATATATTAAGGTGTTCCTGGTAATGAAGGCATGTAAGTTATAATAATTG
TAGCTTTCTGAATAAGTGTCAAACTATATCTTTAAGTGTGCTGTATGCTGAGTTACAAGTTAGGTCATTTATGAATGGAATGTAAAATAA

>77917_77917_4_RPS3-ZNF536_RPS3_chr11_75115227_ENST00000527446_ZNF536_chr19_31039220_ENST00000355537_length(amino acids)=383AA_BP=
MQAFMDSFVLSSLKKEKDMKDKALADPPSMKVHGVDGGEEKPSGKSSQRKSEKSQYEPLDLSVRPDAASLPGSSVTVQDSIAWHGCLFCA
FTTSSMELMALHLQANHLGKAKRKDNTIGVTVNCKDQAREASKMALLPSLQSNKDLGLSNMISSLDSASEKMAQGQLKETLGEQKSGAWT
GHVDPAFCNFPSDFYKQFGVYPGMVGSGASSSCPNKEPDGKAHSEEDVPILIPETTSKNTTDDLSDIASSEDMDSSKGENNDEEDVETEP
EMMTKPLSALSKDSSSDGGDSLQPTGTSQPVQGLVSPLSQAPEKQWHSQGLLQAQDPLAGLPKPERGPQSLDKPMNMLSVLRAYSSDGLA

--------------------------------------------------------------
>77917_77917_5_RPS3-ZNF536_RPS3_chr11_75115227_ENST00000531188_ZNF536_chr19_31039220_ENST00000355537_length(transcript)=2540nt_BP=436nt
CCTTTATACTCACTTCCGCCCGCGAGCCACTTCCTTTCCTTTCAGCGGAGCGCGGCGGCAAGATGGCAGTGCAAATATCCAAGAAGAGGA
AGTTTGTCGCTGATGGCATCTTCAAAGCTGAACTGAATGAGTTTCTTACTCGGGAGCTGGCTGAAGATGGCTACTCTGGAGTTGAGGTGC
GAGTTACACCAACCAGGACAGAAATCATTATCTTAGCCACCAGAACACAGAATGTTCTTGGTGAGAAGGGCCGGCGGATTCGGGAACTGA
CTGCTGTAGTTCAGAAGAGGTTTGGCTTTCCAGAGGGCAGTGTAGAGCTTTATGCTGAAAAGGTGGCCACTAGAGGTCTGTGTGCCATTG
CCCAGGCAGAGTCTCTGCGTTACAAACTCCTAGGAGGGCTTGCTGTGCGGAGTGCGCCACGTGTTGCTCAGACAGGGAGATCGGAAGAGC
TTATCAAAGCATTGTGAGCAACGGTGTGAATTTCCAAGGGTCCTTGCAAGCTTTCATGGACAGTTTTGTCCTCAGTTCCTTGAAGAAGGA
GAAGGACATGAAGGACAAAGCCCTGGCTGACCCCCCTTCCATGAAAGTCCACGGAGTGGATGGTGGTGAGGAGAAACCCAGTGGCAAGTC
CTCCCAGAGGAAGTCCGAGAAATCTCAGTATGAACCCCTGGACTTGTCTGTGCGGCCAGATGCCGCCTCCCTCCCGGGCTCCTCGGTAAC
TGTGCAGGACAGCATTGCATGGCACGGCTGCTTGTTTTGTGCTTTCACAACGTCCTCCATGGAGCTCATGGCCCTTCATCTCCAGGCCAA
CCACCTGGGCAAAGCGAAACGCAAAGATAACACCATCGGGGTCACAGTCAACTGCAAAGACCAAGCCCGGGAGGCGAGTAAGATGGCCCT
GCTGCCCTCGTTACAATCAAACAAAGACCTGGGCCTCTCCAATATGATCAGCTCTCTAGACTCTGCTTCTGAGAAGATGGCCCAAGGTCA
GCTCAAGGAGACTCTGGGAGAGCAGAAGAGCGGTGCATGGACCGGCCACGTGGACCCTGCATTTTGTAACTTCCCATCAGACTTCTACAA
GCAGTTTGGTGTTTACCCAGGCATGGTTGGCTCAGGGGCCTCCAGTTCCTGCCCCAACAAGGAGCCTGATGGAAAGGCCCACTCTGAAGA
GGATGTCCCCATCCTGATCCCCGAAACCACGAGTAAGAACACTACTGATGACCTCTCTGACATTGCCTCCTCAGAGGACATGGACTCCTC
CAAGGGGGAGAACAACGATGAAGAGGATGTTGAAACCGAACCGGAAATGATGACCAAGCCACTGTCTGCCCTCAGCAAAGACAGCAGCAG
CGATGGCGGGGACAGCCTGCAGCCCACAGGCACCTCCCAGCCCGTCCAGGGACTGGTCTCACCTTTATCCCAAGCACCGGAGAAGCAGTG
GCACAGCCAGGGTCTTCTCCAAGCCCAGGACCCCTTGGCGGGCCTGCCAAAGCCGGAGCGGGGGCCCCAGAGCCTGGACAAGCCGATGAA
CATGCTGTCGGTCCTCAGGGCCTACAGTTCTGATGGCTTAGCAGCCTTTAACGGACTTGCAAGTAGCACAGCAAATTCTGGATGTATCAA
GAGGCCAGACTTGTGTGGTAAGTGACACTCCCTGTCCTAGTCGGTCTATCTGGACTTGCCCTTGTCTGTTCGTGGTCCTCGGTGGTTATC
TGCAGCTTGTTAATCGTGTAAAGTCAAGAGAAGAATGTATACACATATGTGTGTTGAATAATTACTATTGGCATAGGTATGTGTATACAC
ACGGTGCACCAATCTACAGTATATATAGCAGAGAATCAGAGGCTAAAAATATTACCCCATATGTTCCAGTATTAGTCATGGATTGCAAAG
GCTTAGTAACTTGAGCAGGAGAGAAAACTCCCTCAAAGTCATAAATCCTGAGTGACAACTGCTGCTGGATGACAGATCCCTTCACCTGTG
GACAACCTGGCTGGGGGTGGGGGGCTGTTCCACCAGCTCACCTGAGCATGTAGAGGTGGGTCCTGCAGTGGTCTCGTGGGTATTACTGCT
TGTGTCTGATTGTCCTGTATTTTGTAACACTTTAGAAGAATACAGAAAAGTGCAGTAATTCTCTTTCTCCATAGTATTTAAGCAGAAATA
TTGCTAGTTTAATATTGTGTCAGGTCGTCCTATTAACCAGGAGCAGATGACAGTAAAATTTCAGTGAATAGCACCTTGACATCTACAACT
TAAAAATGGTGATTGAAGCAAAATATGTAAACTTGTACGGGGTGATCGTGTGCTTTGGAACAGAGTATTGTTGAAGTAATTAGAAGATAT
ATTAAGGTGTTCCTGGTAATGAAGGCATGTAAGTTATAATAATTGTAGCTTTCTGAATAAGTGTCAAACTATATCTTTAAGTGTGCTGTA
TGCTGAGTTACAAGTTAGGTCATTTATGAATGGAATGTAAAATAATACTAAAAATGCTTCAATAACTTATCTTGGTATTGCTAATAAAAA

>77917_77917_5_RPS3-ZNF536_RPS3_chr11_75115227_ENST00000531188_ZNF536_chr19_31039220_ENST00000355537_length(amino acids)=383AA_BP=
MQAFMDSFVLSSLKKEKDMKDKALADPPSMKVHGVDGGEEKPSGKSSQRKSEKSQYEPLDLSVRPDAASLPGSSVTVQDSIAWHGCLFCA
FTTSSMELMALHLQANHLGKAKRKDNTIGVTVNCKDQAREASKMALLPSLQSNKDLGLSNMISSLDSASEKMAQGQLKETLGEQKSGAWT
GHVDPAFCNFPSDFYKQFGVYPGMVGSGASSSCPNKEPDGKAHSEEDVPILIPETTSKNTTDDLSDIASSEDMDSSKGENNDEEDVETEP
EMMTKPLSALSKDSSSDGGDSLQPTGTSQPVQGLVSPLSQAPEKQWHSQGLLQAQDPLAGLPKPERGPQSLDKPMNMLSVLRAYSSDGLA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RPS3-ZNF536


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RPS3-ZNF536


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RPS3-ZNF536


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource