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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:RPS4X-MCTP1 (FusionGDB2 ID:77926)

Fusion Gene Summary for RPS4X-MCTP1

Fusion gene summary

Fusion gene information	Fusion gene name: RPS4X-MCTP1
	Fusion gene ID: 77926
		Hgene	Tgene
	Gene symbol	RPS4X	MCTP1
	Gene ID	6191	79772
	Gene name	ribosomal protein S4 X-linked	multiple C2 and transmembrane domain containing 1
	Synonyms	CCG2\|DXS306\|RPS4\|S4\|SCAR\|SCR10	-
	Cytomap	Xq13.1	5q15
	Type of gene	protein-coding	protein-coding
	Description	40S ribosomal protein S4, X isoformcell cycle gene 2ribosomal protein S4X isoformsingle copy abundant mRNA proteinsingle-copy abundant mRNAsmall ribosomal subunit protein eS4	multiple C2 and transmembrane domain-containing protein 1multiple C2 domains, transmembrane 1multiple C2-domains with two transmembrane regions 1
	Modification date	20200313	20200313
	UniProtAcc	.	Q6DN14
	Ensembl transtripts involved in fusion gene	ENST00000316084, ENST00000373626, ENST00000486733,	ENST00000312216, ENST00000429576, ENST00000505078, ENST00000505208, ENST00000514040, ENST00000515393,
Fusion gene scores	* DoF score	11 X 8 X 4=352	8 X 5 X 7=280
	# samples	12	8
	** MAII score	log2(12/352*10)=-1.55254102302878 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RPS4X [Title/Abstract] AND MCTP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RPS4X(71494903)-MCTP1(94134837), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across RPS4X (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MCTP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-CD-5803-01A	RPS4X	chrX	71494903	-	MCTP1	chr5	94134837	-

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Fusion Gene ORF analysis for RPS4X-MCTP1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000316084	ENST00000312216	RPS4X	chrX	71494903	-	MCTP1	chr5	94134837	-
5CDS-intron	ENST00000316084	ENST00000429576	RPS4X	chrX	71494903	-	MCTP1	chr5	94134837	-
5CDS-intron	ENST00000316084	ENST00000505078	RPS4X	chrX	71494903	-	MCTP1	chr5	94134837	-
5CDS-intron	ENST00000316084	ENST00000505208	RPS4X	chrX	71494903	-	MCTP1	chr5	94134837	-
5CDS-intron	ENST00000316084	ENST00000514040	RPS4X	chrX	71494903	-	MCTP1	chr5	94134837	-
5CDS-intron	ENST00000373626	ENST00000312216	RPS4X	chrX	71494903	-	MCTP1	chr5	94134837	-
5CDS-intron	ENST00000373626	ENST00000429576	RPS4X	chrX	71494903	-	MCTP1	chr5	94134837	-
5CDS-intron	ENST00000373626	ENST00000505078	RPS4X	chrX	71494903	-	MCTP1	chr5	94134837	-
5CDS-intron	ENST00000373626	ENST00000505208	RPS4X	chrX	71494903	-	MCTP1	chr5	94134837	-
5CDS-intron	ENST00000373626	ENST00000514040	RPS4X	chrX	71494903	-	MCTP1	chr5	94134837	-
In-frame	ENST00000316084	ENST00000515393	RPS4X	chrX	71494903	-	MCTP1	chr5	94134837	-
In-frame	ENST00000373626	ENST00000515393	RPS4X	chrX	71494903	-	MCTP1	chr5	94134837	-
intron-3CDS	ENST00000486733	ENST00000515393	RPS4X	chrX	71494903	-	MCTP1	chr5	94134837	-
intron-intron	ENST00000486733	ENST00000312216	RPS4X	chrX	71494903	-	MCTP1	chr5	94134837	-
intron-intron	ENST00000486733	ENST00000429576	RPS4X	chrX	71494903	-	MCTP1	chr5	94134837	-
intron-intron	ENST00000486733	ENST00000505078	RPS4X	chrX	71494903	-	MCTP1	chr5	94134837	-
intron-intron	ENST00000486733	ENST00000505208	RPS4X	chrX	71494903	-	MCTP1	chr5	94134837	-
intron-intron	ENST00000486733	ENST00000514040	RPS4X	chrX	71494903	-	MCTP1	chr5	94134837	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000316084	RPS4X	chrX	71494903	-	ENST00000515393	MCTP1	chr5	94134837	-	3425	465	90	1028	312
ENST00000373626	RPS4X	chrX	71494903	-	ENST00000515393	MCTP1	chr5	94134837	-	3373	413	38	976	312

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000316084	ENST00000515393	RPS4X	chrX	71494903	-	MCTP1	chr5	94134837	-	9.82E-05	0.9999018
ENST00000373626	ENST00000515393	RPS4X	chrX	71494903	-	MCTP1	chr5	94134837	-	9.39E-05	0.99990606

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Fusion Genomic Features for RPS4X-MCTP1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RPS4X-MCTP1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:71494903/chr5:94134837)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	MCTP1 Q6DN14
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity. {ECO:0000250\|UniProtKB:A1ZBD6}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RPS4X

chrX:71494903

chr5:94134837

ENST00000316084

42_104

120

264.0

Domain

Note=S4 RNA-binding

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000429576

152_169

693.0

Compositional bias

Note=Ser-rich

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000505208

152_169

601.0

Compositional bias

Note=Ser-rich

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000312216

603_724

591

779.0

Domain

C2 3

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000429576

242_360

693.0

Domain

C2 1

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000429576

452_569

693.0

Domain

C2 2

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000429576

603_724

693.0

Domain

C2 3

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000505078

452_569

328

516.0

Domain

C2 2

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000505078

603_724

328

516.0

Domain

C2 3

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000505208

242_360

601.0

Domain

C2 1

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000505208

452_569

601.0

Domain

C2 2

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000505208

603_724

601.0

Domain

C2 3

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000312216

811_831

591

779.0

Transmembrane

Helical

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000312216

914_934

591

779.0

Transmembrane

Helical

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000429576

811_831

693.0

Transmembrane

Helical

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000429576

914_934

693.0

Transmembrane

Helical

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000505078

811_831

328

516.0

Transmembrane

Helical

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000505078

914_934

328

516.0

Transmembrane

Helical

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000505208

811_831

601.0

Transmembrane

Helical

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000505208

914_934

601.0

Transmembrane

Helical

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000515393

811_831

812

1000.0

Transmembrane

Helical

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000515393

914_934

812

1000.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000312216

152_169

591

779.0

Compositional bias

Note=Ser-rich

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000505078

152_169

328

516.0

Compositional bias

Note=Ser-rich

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000515393

152_169

812

1000.0

Compositional bias

Note=Ser-rich

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000312216

242_360

591

779.0

Domain

C2 1

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000312216

452_569

591

779.0

Domain

C2 2

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000505078

242_360

328

516.0

Domain

C2 1

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000515393

242_360

812

1000.0

Domain

C2 1

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000515393

452_569

812

1000.0

Domain

C2 2

Tgene

MCTP1

chrX:71494903

chr5:94134837

ENST00000515393

603_724

812

1000.0

Domain

C2 3

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Fusion Gene Sequence for RPS4X-MCTP1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>77926_77926_1_RPS4X-MCTP1_RPS4X_chrX_71494903_ENST00000316084_MCTP1_chr5_94134837_ENST00000515393_length(transcript)=3425nt_BP=465nt
GGCTGAGCTGGGCGGAGCAGCTGAAAATCCGGCGCGCGCAGTCTCCAGCCCCAATTTCTACGCGCACCGGAAGACGGAGGTCCTCTTTCC
TTGCCTAACGCAGCCATGGCTCGTGGTCCCAAGAAGCATCTGAAGCGGGTGGCAGCTCCAAAGCATTGGATGCTGGATAAATTGACCGGT
GTGTTTGCTCCTCGTCCATCCACCGGTCCCCACAAGTTGAGAGAGTGTCTCCCCCTCATCATTTTCCTGAGGAACAGACTTAAGTATGCC
CTGACAGGAGATGAAGTAAAGAAGATTTGCATGCAGCGGTTCATTAAAATCGATGGCAAGGTCCGAACTGATATAACCTACCCTGCTGGA
TTCATGGATGTCATCAGCATTGACAAGACGGGAGAGAATTTCCGTCTGATCTATGACACCAAGGGTCGCTTTGCTGTACATCGTATTACA
CCTGAGGAGGCCAAGCTCTTTCTCTTTGTTGTCTGGAACTTTGAGCTCTACATGATACCACTGGTTTTGTTGTTACTATTGACATGGAAC
TACTTCTTGATAATATCAGGGAAAGATAACAGGCAACGTGATACAGTAGTGGAGGACATGCTAGAGGACGAGGAAGAAGAAGATGACAAA
GATGACAAGGACAGTGAAAAAAAGGGATTTATAAATAAAATCTATGCCATCCAGGAGGTATGTGTCAGTGTCCAGAACATCCTAGATGAA
GTGGCTTCCTTTGGCGAAAGGATAAAGAATACTTTCAACTGGACTGTCCCATTCTTAAGCTGGCTGGCCATTGTAGCCCTCTGTGTGTTC
ACAGCCATCCTGTACTGCATTCCGCTGAGATACATTGTCCTTGTCTGGGGCATCAATAAATTTACAAAAAAGCTTCGGAGTCCATATGCA
ATTGATAACAATGAACTACTTGACTTCCTTTCCAGAGTCCCTTCAGATGTACAAGTGGTGCAATACCAAGAACTGAAACCAGATCCTTCT
CATAGCCCATATAAAAGAAAGAAAAACAATCTTGGCTAGCCAGCTCCCAGCACTGAGGAGACCAGCATCTGTTTGGGAAGATAAAAGAAA
AAGCCCTCAGCCTCAGCAGCATTTCCTTTCTTTCTGCTTTTTATTTATTTTGCCTTTTTATCATGATCGAGAGAATCTGTAAATAGTGTA
CAAAGGCATATGTCTTTGAATATATACTTCTATTGTACAGACTCAACTTGATAAAGGTTTTGCTACTGCTGTGTCAAAACCTTGTTAGCT
GTGGATAATAATATAACACACTGAAAGAACAAATATAAGAATGATAACACTGGAAGATATATTCTTATCTAATTACTAGTGGATTAAATA
CTCACCTGTGCTCTGATTAAATCTACATCAATTGTAAATGTCGATTTGATTTTAAAGTTTTTTTTTAATGCGACTATTTTTTATCTGAAA
AGTAATCCATTACACTTTTCTATGTTTTATACATTTCAAAAGGGAGGGAAATTCCAAAGCCTGAATAATGGAATGGATACATTTCAATTT
AACATATATTCTGGCTTTAGATCCCGACATTCACTCCTGTGCAAATTACTTAGGTATGACTTAGGCTAATTTTAAGCTAATAAGTGAAGG
TACATTCACTCCCTCAAGAGAATCAATACTCAGAAGGTTACAAAGTTTTCTTTATAGAATTTCAATCAATCATTCCATCTAAAACCTTAA
AATCTCTACAGGACTACATAACATAAATACTGCCAGTTTATAAACGATTGCCTATCTGAATTTTTATACCTACCACTACTTTAATTTATA
CAGTTAGTTAGCAAATTAGCAACCCAGTAAGTACAGTTATCAAAAATACTAGGAAACTATATCCATATCGCTTTTGGTGTCAGATTGTAT
CTGTGCATCTAAAAATATTTTAATAAATACTCAAGTGCTCTCAGAGAAAAAAAAAACCTGCTTTCTCATTAGATTACTGAAATGCTTTAA
TTCATACTATGATTTTGTTATTAGTGTGAATTTTAATGTAGAGAATTCAGTGTGCTAAGTGATATGCCAGTGTTTCACTACATTCATTTA
TTAAAAAAAATCATTCTTGATTATGCATGAAAACCTGTTTTGTAAAATAAAATAAACTGCTTGGGGGTGGTGGTTGCCTTTATCAATGTT
TCACTATTATCATAGAATCTATACTTAAAAATTGCATTCCCAAGACTCTTAAAGTAGTTTTTATATCTCACTCCCTGGTATACTAAGGGA
GCATAACTCTGGAGAAAAAATAATTTGGTTGGTTGAGAATGTCTTACTTCCCTGACTTGGTAGGGGACTACACTCAGTTGAAATTGCAGC
AGACAATGCTTTGCACTACTTTATTAATAATAAACTTGGATGGGGTAAAAGTGGGGGTTATACTGGAAAAACTATAGAAAAGCTAAAAGA
AATGTATATTTCACTCTAAAGGAAGATTCTTTAACAATAAATGTAATCTCATTGAAGCTGATTTTTAAAGTATTTTTATTTTAGAGATAA
GTTGTTAAATACTATTTCTTATAATAGAACTATTTTGATCTGTTTATATACTATGCTTGAATGTCAATTAAATTCCCTTTCTACAGAAAG
GCTTTGACCTCAACATGCTTTATTTAATGTATCATGTTTAAAATGACATGCTTCTGTCTGCATACCATCACTGTTTGTTGCTAAAAACAT
AATGTTCCATGAACATGATGTTACTACAGAAAGTTTATTGATGAGATAACTGTTTGAAATAACTTTCAATTATACCTTATGTGAGACTTT
TATGTTCTGTGCTGACAATGTGTACTCAAATGTCTATAAGCCTGATATTCTACAACCTCAGATGTATCTAGTGGATAGTAACCATTAACA
GATGACTAATTTGTTTCACTGTATCAAATTTCAGATGTTTAGTTCAATGGTAATGCTGACTACACATTCACTGTATTAAATACAAAAGAA
AATAATCTTTCCCACGTATAATCAGCACTCCTTTTTTTTTTTTTTTTGGTGGTTCAGAGATTGATGAGGGATTGTGTGCATATTCTTAAA
AACTATATGTCACTTGGAGAAAAACAGATTTGGTTTAAACAAATAAGACCTTTTTCCTGAAACTCTGACTCTTATATGAAAATACCTCTG
GAGGGGTGAGCAACCAATGACATTAACAGAGGAATAAGAACTAGCTTGAGGCACAAAAGTGATATTCAGGGAAATCTTCATTGCTTTTAG
AAACTACTACATTCACAGGCTGAAAACAGAATATGTATAGTTAAAATTTTAACTATTTATTTCTTTCCCCTTCTCACATAGCTGCAATTC
TGTCTTGAGAGCTGCCTGACTTGCCTTCATTTTGAGATCTGTGATGTAAATATTTCTTAAGAGACTGAATGTCACTCAAACATCTACTTG

>77926_77926_1_RPS4X-MCTP1_RPS4X_chrX_71494903_ENST00000316084_MCTP1_chr5_94134837_ENST00000515393_length(amino acids)=312AA_BP=125
MPNAAMARGPKKHLKRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIIFLRNRLKYALTGDEVKKICMQRFIKIDGKVRTDITYPAG
FMDVISIDKTGENFRLIYDTKGRFAVHRITPEEAKLFLFVVWNFELYMIPLVLLLLLTWNYFLIISGKDNRQRDTVVEDMLEDEEEEDDK
DDKDSEKKGFINKIYAIQEVCVSVQNILDEVASFGERIKNTFNWTVPFLSWLAIVALCVFTAILYCIPLRYIVLVWGINKFTKKLRSPYA

--------------------------------------------------------------
>77926_77926_2_RPS4X-MCTP1_RPS4X_chrX_71494903_ENST00000373626_MCTP1_chr5_94134837_ENST00000515393_length(transcript)=3373nt_BP=413nt
AATTTCTACGCGCACCGGAAGACGGAGGTCCTCTTTCCTTGCCTAACGCAGCCATGGCTCGTGGTCCCAAGAAGCATCTGAAGCGGGTGG
CAGCTCCAAAGCATTGGATGCTGGATAAATTGACCGGTGTGTTTGCTCCTCGTCCATCCACCGGTCCCCACAAGTTGAGAGAGTGTCTCC
CCCTCATCATTTTCCTGAGGAACAGACTTAAGTATGCCCTGACAGGAGATGAAGTAAAGAAGATTTGCATGCAGCGGTTCATTAAAATCG
ATGGCAAGGTCCGAACTGATATAACCTACCCTGCTGGATTCATGGATGTCATCAGCATTGACAAGACGGGAGAGAATTTCCGTCTGATCT
ATGACACCAAGGGTCGCTTTGCTGTACATCGTATTACACCTGAGGAGGCCAAGCTCTTTCTCTTTGTTGTCTGGAACTTTGAGCTCTACA
TGATACCACTGGTTTTGTTGTTACTATTGACATGGAACTACTTCTTGATAATATCAGGGAAAGATAACAGGCAACGTGATACAGTAGTGG
AGGACATGCTAGAGGACGAGGAAGAAGAAGATGACAAAGATGACAAGGACAGTGAAAAAAAGGGATTTATAAATAAAATCTATGCCATCC
AGGAGGTATGTGTCAGTGTCCAGAACATCCTAGATGAAGTGGCTTCCTTTGGCGAAAGGATAAAGAATACTTTCAACTGGACTGTCCCAT
TCTTAAGCTGGCTGGCCATTGTAGCCCTCTGTGTGTTCACAGCCATCCTGTACTGCATTCCGCTGAGATACATTGTCCTTGTCTGGGGCA
TCAATAAATTTACAAAAAAGCTTCGGAGTCCATATGCAATTGATAACAATGAACTACTTGACTTCCTTTCCAGAGTCCCTTCAGATGTAC
AAGTGGTGCAATACCAAGAACTGAAACCAGATCCTTCTCATAGCCCATATAAAAGAAAGAAAAACAATCTTGGCTAGCCAGCTCCCAGCA
CTGAGGAGACCAGCATCTGTTTGGGAAGATAAAAGAAAAAGCCCTCAGCCTCAGCAGCATTTCCTTTCTTTCTGCTTTTTATTTATTTTG
CCTTTTTATCATGATCGAGAGAATCTGTAAATAGTGTACAAAGGCATATGTCTTTGAATATATACTTCTATTGTACAGACTCAACTTGAT
AAAGGTTTTGCTACTGCTGTGTCAAAACCTTGTTAGCTGTGGATAATAATATAACACACTGAAAGAACAAATATAAGAATGATAACACTG
GAAGATATATTCTTATCTAATTACTAGTGGATTAAATACTCACCTGTGCTCTGATTAAATCTACATCAATTGTAAATGTCGATTTGATTT
TAAAGTTTTTTTTTAATGCGACTATTTTTTATCTGAAAAGTAATCCATTACACTTTTCTATGTTTTATACATTTCAAAAGGGAGGGAAAT
TCCAAAGCCTGAATAATGGAATGGATACATTTCAATTTAACATATATTCTGGCTTTAGATCCCGACATTCACTCCTGTGCAAATTACTTA
GGTATGACTTAGGCTAATTTTAAGCTAATAAGTGAAGGTACATTCACTCCCTCAAGAGAATCAATACTCAGAAGGTTACAAAGTTTTCTT
TATAGAATTTCAATCAATCATTCCATCTAAAACCTTAAAATCTCTACAGGACTACATAACATAAATACTGCCAGTTTATAAACGATTGCC
TATCTGAATTTTTATACCTACCACTACTTTAATTTATACAGTTAGTTAGCAAATTAGCAACCCAGTAAGTACAGTTATCAAAAATACTAG
GAAACTATATCCATATCGCTTTTGGTGTCAGATTGTATCTGTGCATCTAAAAATATTTTAATAAATACTCAAGTGCTCTCAGAGAAAAAA
AAAACCTGCTTTCTCATTAGATTACTGAAATGCTTTAATTCATACTATGATTTTGTTATTAGTGTGAATTTTAATGTAGAGAATTCAGTG
TGCTAAGTGATATGCCAGTGTTTCACTACATTCATTTATTAAAAAAAATCATTCTTGATTATGCATGAAAACCTGTTTTGTAAAATAAAA
TAAACTGCTTGGGGGTGGTGGTTGCCTTTATCAATGTTTCACTATTATCATAGAATCTATACTTAAAAATTGCATTCCCAAGACTCTTAA
AGTAGTTTTTATATCTCACTCCCTGGTATACTAAGGGAGCATAACTCTGGAGAAAAAATAATTTGGTTGGTTGAGAATGTCTTACTTCCC
TGACTTGGTAGGGGACTACACTCAGTTGAAATTGCAGCAGACAATGCTTTGCACTACTTTATTAATAATAAACTTGGATGGGGTAAAAGT
GGGGGTTATACTGGAAAAACTATAGAAAAGCTAAAAGAAATGTATATTTCACTCTAAAGGAAGATTCTTTAACAATAAATGTAATCTCAT
TGAAGCTGATTTTTAAAGTATTTTTATTTTAGAGATAAGTTGTTAAATACTATTTCTTATAATAGAACTATTTTGATCTGTTTATATACT
ATGCTTGAATGTCAATTAAATTCCCTTTCTACAGAAAGGCTTTGACCTCAACATGCTTTATTTAATGTATCATGTTTAAAATGACATGCT
TCTGTCTGCATACCATCACTGTTTGTTGCTAAAAACATAATGTTCCATGAACATGATGTTACTACAGAAAGTTTATTGATGAGATAACTG
TTTGAAATAACTTTCAATTATACCTTATGTGAGACTTTTATGTTCTGTGCTGACAATGTGTACTCAAATGTCTATAAGCCTGATATTCTA
CAACCTCAGATGTATCTAGTGGATAGTAACCATTAACAGATGACTAATTTGTTTCACTGTATCAAATTTCAGATGTTTAGTTCAATGGTA
ATGCTGACTACACATTCACTGTATTAAATACAAAAGAAAATAATCTTTCCCACGTATAATCAGCACTCCTTTTTTTTTTTTTTTTGGTGG
TTCAGAGATTGATGAGGGATTGTGTGCATATTCTTAAAAACTATATGTCACTTGGAGAAAAACAGATTTGGTTTAAACAAATAAGACCTT
TTTCCTGAAACTCTGACTCTTATATGAAAATACCTCTGGAGGGGTGAGCAACCAATGACATTAACAGAGGAATAAGAACTAGCTTGAGGC
ACAAAAGTGATATTCAGGGAAATCTTCATTGCTTTTAGAAACTACTACATTCACAGGCTGAAAACAGAATATGTATAGTTAAAATTTTAA
CTATTTATTTCTTTCCCCTTCTCACATAGCTGCAATTCTGTCTTGAGAGCTGCCTGACTTGCCTTCATTTTGAGATCTGTGATGTAAATA

>77926_77926_2_RPS4X-MCTP1_RPS4X_chrX_71494903_ENST00000373626_MCTP1_chr5_94134837_ENST00000515393_length(amino acids)=312AA_BP=125
MPNAAMARGPKKHLKRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIIFLRNRLKYALTGDEVKKICMQRFIKIDGKVRTDITYPAG
FMDVISIDKTGENFRLIYDTKGRFAVHRITPEEAKLFLFVVWNFELYMIPLVLLLLLTWNYFLIISGKDNRQRDTVVEDMLEDEEEEDDK
DDKDSEKKGFINKIYAIQEVCVSVQNILDEVASFGERIKNTFNWTVPFLSWLAIVALCVFTAILYCIPLRYIVLVWGINKFTKKLRSPYA

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Fusion Gene PPI Analysis for RPS4X-MCTP1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for RPS4X-MCTP1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for RPS4X-MCTP1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source