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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:RPS6-DPP10 (FusionGDB2 ID:77978)

Fusion Gene Summary for RPS6-DPP10

Fusion gene summary

Fusion gene information	Fusion gene name: RPS6-DPP10
	Fusion gene ID: 77978
		Hgene	Tgene
	Gene symbol	RPS6	DPP10
	Gene ID	6194	57628
	Gene name	ribosomal protein S6	dipeptidyl peptidase like 10
	Synonyms	S6	DPL2\|DPPY\|DPRP-3\|DPRP3
	Cytomap	9p22.1	2q14.1
	Type of gene	protein-coding	protein-coding
	Description	40S ribosomal protein S6phosphoprotein NP33small ribosomal subunit protein eS6	inactive dipeptidyl peptidase 10DPP Xdipeptidyl peptidase 10dipeptidyl peptidase IV-related protein 3dipeptidyl peptidase Xdipeptidyl peptidase-like protein 2dipeptidyl-peptidase 10 (inactive)dipeptidyl-peptidase 10 (non-functional)
	Modification date	20200313	20200313
	UniProtAcc	.	Q8N608
	Ensembl transtripts involved in fusion gene	ENST00000380381, ENST00000380394, ENST00000315377, ENST00000380384, ENST00000498815,	ENST00000310323, ENST00000393147, ENST00000409163, ENST00000488208, ENST00000410059,
Fusion gene scores	* DoF score	28 X 23 X 7=4508	12 X 13 X 3=468
	# samples	32	13
	** MAII score	log2(32/4508*10)=-3.81634370528486 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/468*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RPS6 [Title/Abstract] AND DPP10 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RPS6(19380187)-DPP10(116066814), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPS6	GO:0031929	TOR signaling	16428328
Hgene	RPS6	GO:0043065	positive regulation of apoptotic process	18362888
Tgene	DPP10	GO:1903078	positive regulation of protein localization to plasma membrane	15671030

Fusion gene breakpoints across RPS6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DPP10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-29-2414	RPS6	chr9	19380187	-	DPP10	chr2	116066814	+

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Fusion Gene ORF analysis for RPS6-DPP10

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000380381	ENST00000310323	RPS6	chr9	19380187	-	DPP10	chr2	116066814	+
5CDS-5UTR	ENST00000380381	ENST00000393147	RPS6	chr9	19380187	-	DPP10	chr2	116066814	+
5CDS-5UTR	ENST00000380381	ENST00000409163	RPS6	chr9	19380187	-	DPP10	chr2	116066814	+
5CDS-5UTR	ENST00000380394	ENST00000310323	RPS6	chr9	19380187	-	DPP10	chr2	116066814	+
5CDS-5UTR	ENST00000380394	ENST00000393147	RPS6	chr9	19380187	-	DPP10	chr2	116066814	+
5CDS-5UTR	ENST00000380394	ENST00000409163	RPS6	chr9	19380187	-	DPP10	chr2	116066814	+
5CDS-intron	ENST00000380381	ENST00000488208	RPS6	chr9	19380187	-	DPP10	chr2	116066814	+
5CDS-intron	ENST00000380394	ENST00000488208	RPS6	chr9	19380187	-	DPP10	chr2	116066814	+
In-frame	ENST00000380381	ENST00000410059	RPS6	chr9	19380187	-	DPP10	chr2	116066814	+
In-frame	ENST00000380394	ENST00000410059	RPS6	chr9	19380187	-	DPP10	chr2	116066814	+
intron-3CDS	ENST00000315377	ENST00000410059	RPS6	chr9	19380187	-	DPP10	chr2	116066814	+
intron-3CDS	ENST00000380384	ENST00000410059	RPS6	chr9	19380187	-	DPP10	chr2	116066814	+
intron-3CDS	ENST00000498815	ENST00000410059	RPS6	chr9	19380187	-	DPP10	chr2	116066814	+
intron-5UTR	ENST00000315377	ENST00000310323	RPS6	chr9	19380187	-	DPP10	chr2	116066814	+
intron-5UTR	ENST00000315377	ENST00000393147	RPS6	chr9	19380187	-	DPP10	chr2	116066814	+
intron-5UTR	ENST00000315377	ENST00000409163	RPS6	chr9	19380187	-	DPP10	chr2	116066814	+
intron-5UTR	ENST00000380384	ENST00000310323	RPS6	chr9	19380187	-	DPP10	chr2	116066814	+
intron-5UTR	ENST00000380384	ENST00000393147	RPS6	chr9	19380187	-	DPP10	chr2	116066814	+
intron-5UTR	ENST00000380384	ENST00000409163	RPS6	chr9	19380187	-	DPP10	chr2	116066814	+
intron-5UTR	ENST00000498815	ENST00000310323	RPS6	chr9	19380187	-	DPP10	chr2	116066814	+
intron-5UTR	ENST00000498815	ENST00000393147	RPS6	chr9	19380187	-	DPP10	chr2	116066814	+
intron-5UTR	ENST00000498815	ENST00000409163	RPS6	chr9	19380187	-	DPP10	chr2	116066814	+
intron-intron	ENST00000315377	ENST00000488208	RPS6	chr9	19380187	-	DPP10	chr2	116066814	+
intron-intron	ENST00000380384	ENST00000488208	RPS6	chr9	19380187	-	DPP10	chr2	116066814	+
intron-intron	ENST00000498815	ENST00000488208	RPS6	chr9	19380187	-	DPP10	chr2	116066814	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000380394

RPS6

chr9

19380187

ENST00000410059

DPP10

chr2

116066814

5803

2395

778

ENST00000380381

RPS6

chr9

19380187

ENST00000410059

DPP10

chr2

116066814

5785

2377

778

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000380394	ENST00000410059	RPS6	chr9	19380187	-	DPP10	chr2	116066814	+	0.00034505	0.999655
ENST00000380381	ENST00000410059	RPS6	chr9	19380187	-	DPP10	chr2	116066814	+	0.000345143	0.9996549

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Fusion Genomic Features for RPS6-DPP10

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
RPS6	chr9	19380187	-	DPP10	chr2	116066814	+	0.000933478	0.99906653
RPS6	chr9	19380187	-	DPP10	chr2	116066814	+	0.000933478	0.99906653

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RPS6-DPP10

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:19380187/chr2:116066814)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	DPP10 Q8N608
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437). Has no dipeptidyl aminopeptidase activity (PubMed:12662155). {ECO:0000269\|PubMed:12662155, ECO:0000269\|PubMed:15454437, ECO:0000269\|PubMed:15671030}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DPP10

chr9:19380187

chr2:116066814

ENST00000409163

1_56

747.0

Region

Note=Mediates effects on KCND2

Tgene

DPP10

chr9:19380187

chr2:116066814

ENST00000310323

56_796

790.0

Topological domain

Extracellular

Tgene

DPP10

chr9:19380187

chr2:116066814

ENST00000393147

56_796

801.0

Topological domain

Extracellular

Tgene

DPP10

chr9:19380187

chr2:116066814

ENST00000409163

1_34

747.0

Topological domain

Cytoplasmic

Tgene

DPP10

chr9:19380187

chr2:116066814

ENST00000409163

56_796

747.0

Topological domain

Extracellular

Tgene

DPP10

chr9:19380187

chr2:116066814

ENST00000410059

56_796

797.0

Topological domain

Extracellular

Tgene

DPP10

chr9:19380187

chr2:116066814

ENST00000310323

35_55

790.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

DPP10

chr9:19380187

chr2:116066814

ENST00000393147

35_55

801.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

DPP10

chr9:19380187

chr2:116066814

ENST00000409163

35_55

747.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

DPP10

chr9:19380187

chr2:116066814

ENST00000410059

35_55

797.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DPP10

chr9:19380187

chr2:116066814

ENST00000310323

1_56

790.0

Region

Note=Mediates effects on KCND2

Tgene

DPP10

chr9:19380187

chr2:116066814

ENST00000393147

1_56

801.0

Region

Note=Mediates effects on KCND2

Tgene

DPP10

chr9:19380187

chr2:116066814

ENST00000410059

1_56

797.0

Region

Note=Mediates effects on KCND2

Tgene

DPP10

chr9:19380187

chr2:116066814

ENST00000310323

1_34

790.0

Topological domain

Cytoplasmic

Tgene

DPP10

chr9:19380187

chr2:116066814

ENST00000393147

1_34

801.0

Topological domain

Cytoplasmic

Tgene

DPP10

chr9:19380187

chr2:116066814

ENST00000410059

1_34

797.0

Topological domain

Cytoplasmic

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Fusion Gene Sequence for RPS6-DPP10

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>77978_77978_1_RPS6-DPP10_RPS6_chr9_19380187_ENST00000380381_DPP10_chr2_116066814_ENST00000410059_length(transcript)=5785nt_BP=47nt
CTCTTTTCCGTGGCGCCTCGGAGGCGTTCAGCTGCTTCAAGATGAAGGAACTGGGAAGTAACAGCCCTCCACAGAGAAACTGGAAGGGAA
TTGCTATTGCTCTGCTGGTGATTTTAGTTGTATGCTCACTCATCACTATGTCAGTCATCCTCTTAACCCCAGATGAACTCACAAATTCGT
CAGAAACCAGATTGTCTTTGGAAGACCTCTTTAGGAAAGACTTTGTGCTTCACGATCCAGAGGCTCGGTGGATCAATGATACAGATGTGG
TGTATAAAAGCGAGAATGGACATGTCATTAAACTGAATATAGAAACAAATGCTACCACATTATTATTGGAAAACACAACTTTTGTAACCT
TCAAAGCATCAAGACATTCAGTTTCACCAGATTTAAAATATGTCCTTCTGGCATATGATGTCAAACAGATTTTTCATTATTCGTATACTG
CTTCATATGTGATTTACAACATACACACTAGGGAAGTTTGGGAGTTAAATCCTCCAGAAGTAGAGGACTCCGTCTTGCAGTACGCGGCCT
GGGGTGTCCAAGGGCAGCAGCTGATTTATATTTTTGAAAATAATATCTACTATCAACCTGATATAAAGAGCAGTTCATTGCGACTGACAT
CTTCTGGAAAAGAAGAAATAATTTTTAATGGGATTGCTGACTGGTTATATGAAGAGGAACTCCTGCATTCTCACATCGCCCACTGGTGGT
CACCAGATGGAGAAAGACTTGCCTTCCTGATGATAAATGACTCTTTGGTACCCACCATGGTTATCCCTCGGTTTACTGGAGCGTTGTATC
CCAAAGGAAAGCAGTATCCGTATCCTAAGGCAGGTCAAGTGAACCCAACAATAAAATTATATGTTGTAAACCTGTATGGACCAACTCACA
CTTTGGAGCTCATGCCACCTGACAGCTTTAAATCAAGAGAATACTATATCACTATGGTTAAATGGGTAAGCAATACCAAGACTGTGGTAA
GATGGTTAAACCGAGCTCAGAACATCTCCATCCTCACAGTCTGTGAGACCACTACAGGTGCTTGTAGTAAAAAATATGAGATGACATCAG
ATACGTGGCTCTCTCAGCAGAATGAGGAGCCCGTGTTTTCTAGAGACGGCAGCAAATTCTTTATGACAGTGCCTGTTAAGCAAGGGGGAC
GTGGAGAATTTCACCACGTAGCTATGTTCCTCATCCAGAGTAAAAGTGAGCAAATTACCGTGCGGCATCTGACATCAGGAAACTGGGAAG
TGATAAAGATCTTGGCATACGATGAAACTACTCAAAAAATTTACTTTCTGAGCACTGAATCTTCTCCCAGAGGAAGGCAGCTGTACAGTG
CTTCTACTGAAGGATTATTGAATCGCCAATGCATTTCATGTAATTTCATGAAAGAACAATGTACATATTTTGATGCCAGTTTTAGTCCCA
TGAATCAACATTTCTTATTATTCTGTGAAGGTCCAAGGGTCCCAGTGGTCAGCCTACATAGTACGGACAACCCAGCAAAATATTTTATAT
TGGAAAGCAATTCTATGCTGAAGGAAGCTATCCTGAAGAAGAAGATAGGAAAGCCAGAAATTAAAATCCTTCATATTGACGACTATGAAC
TTCCTTTACAGTTGTCCCTTCCCAAAGATTTTATGGACCGAAACCAGTATGCTCTTCTGTTAATAATGGATGAAGAACCAGGAGGCCAGC
TGGTTACAGATAAGTTCCATATTGACTGGGATTCCGTACTCATTGACATGGATAATGTCATTGTAGCAAGATTTGATGGCAGAGGAAGTG
GATTCCAGGGTCTGAAAATTTTGCAGGAGATTCATCGAAGATTAGGTTCAGTAGAAGTAAAGGACCAAATAACAGCTGTGAAATTTTTGC
TGAAACTGCCTTACATTGACTCCAAAAGATTAAGCATTTTTGGAAAGGGTTATGGTGGCTATATTGCATCAATGATCTTAAAATCAGATG
AAAAGCTTTTTAAATGTGGATCCGTGGTTGCACCTATCACAGACTTGAAATTGTATGCCTCAGCTTTCTCTGAAAGATACCTTGGGATGC
CATCTAAGGAAGAAAGCACTTACCAGGCAGCCAGTGTGCTACATAATGTTCATGGCTTGAAAGAAGAAAATATATTAATAATTCATGGAA
CTGCTGACACAAAAGTTCATTTCCAACACTCAGCAGAATTAATCAAGCACCTAATAAAAGCTGGAGTGAATTATACTATGCAGGTCTACC
CAGATGAAGGTCATAACGTATCTGAGAAGAGCAAGTATCATCTCTACAGCACAATCCTCAAATTCTTCAGTGATTGTTTGAAGGAAGAAA
TATCTGTGCTACCACAGGAACCAGAAGAAGATGAATAATGGACTGTATTTATACAGAACTGAAGGGAATATTGAGGCTCAATGAAACCTG
ACAAAGAGACTGTAATATTGTAGTTGCTCCAGAATGTCAAGGGCAGCTTACGGAGATGTCACTGGAGCAGCACGCTCAGAGACAGTGAAC
TAGCATTTGAATACACAAGTCCAAGTCTACTGTGTTGCTAGGGGTGCAGAACCCGTTTCTTTGTATGAGAGAGGTCAAAGGGTTGGTTTC
CTGGGAGAAATTAGTTTTGCATTAAAGTAGGAGTAGTGCATGTTTTCTTCTGTTATCCCCCTGTTTGTTCTGTAACTAGTTGCTCTCATT
TTAATTTCACTGGCCACCATCATCTTTGCATATAATGCACAATCTATCATCTGTCCTACAGTCCCTGATCTTTCATGGCTGAGCTGCAAT
CTAACACTTTACTGTACCTTTATAATAAGTGCAATTCTTTCATTGTCTATTATTATGCTTAAGAAAATATTCAGTTAATAAAAAACAGAG
TATTTTATGTAATTTCTGTTTTTAAAAAGACATTATTAAATGGGTCAAAGGACATATAGAAATGTGGATTTCAGCACCTTCCAAAGTTCA
GCCAGTTATCAGTAGATACAATATCTTTAAATGAACACACGAGTGTATGTCTCACAATATATATACACAAGTGTGCATATACAGTTAATG
AAACTATCTTTAAATGTTATTCATGCTATAAAGAGTAAACGTTTGATGAATTAGAAGAGATGCTCTTTTCCAAGCTATAATGGATGCTTT
GTTTAATGAGCCAAATATGATGAAACATTTTTTCCAATTCAAATTCTAGCTATTGCTTTCCTATAAATGTTTGGGTTGTGTTTGGTATTG
TTTTTAGTGGTTAATAGTTTTCCAGTTGCATTTAATTTTTTGAATATGATACCTTGTCACATGTAAATTAGATACTTAAATATTAAATTA
TAGTTTCTGATAAAGAAATTTTGTTAACAATGCAATGCCACTGAGTGCTATTTTGCTCTTTTGGTGGAGAAGGCTTTTTTCAAAACTCTT
GGTCCTTTTACTTCTTTCTCTCAGTGCAGAATCAATTCTCATTTTCATCGTAAAAGCAAATAGCTGGATTATTTCATTTGCCAGTTTCTA
TTTAGTATTCCATGCCTGCCCAATTCATCTGTTACTGTTTAATTTCAATTCTTCTGGTGAGAATTAGAAATGAAATATTTTTTATTCATT
GGCCAAAAAGTTCACAGACAGCAGTGTTTGCTATTTACTTTGAATTGAAGGCACAAAATGCATCAATTCCTGTGCTGTGTTGACTTGCAG
TAGTAAGTAACTGAGAGCATAAAATAAACCTGACTGTATGAAGTCAATTTAAGTGATGAGAACATTTAACTTTGGTGACTAAAGTCAGAA
TATCTTCTCACTTCACTTAAGGGATCTTCCAGAAGATATCTAAAAGTCTGTAATAAGCTTAGAAGTTCAGATAAATCTAGGCAGGATACT
GCATTTTTGTGGTTTTAAAAAAGTCCTTAGGACAGACTGAATTATCATAACTTATGGCATCAGGAGGAAACTTTAAAATATCAAGGAATC
ACTCAGTCACCCTCCTGTTTTGTTGAAGGATCAACCCCAAATTCTGGGTATTTGAGTACATGTGAATCATGGATTTGGTATTCAACTTTT
TCCCTGGATGCTTTGGAATCGTGTCTTCCATGCTCCACTGGGTTCAATTTAAAATAGGAGAGGCTTTCTCTTCTGAAAGATCCATTTTAG
GTCTTTTTCAAGAATAGTGAACACATTTTTTAACAAAATAAGTTGTAATTTTAAAAGGAAAGTTTTGCCTATTTTATTAAGATGGAAATT
TCTTTTTAGGCTAATTTGAAATCCAACTGAAGCTTTTTAACCAATATTTTAAATTTGAACCACTAGAGTTTTTTATGATGCAAATGATTA
TGTTGTCTGAAAGGTGTGGTTTTATTGAATGTCTATTTGAGTATCATTTAAAAAGTATTTGCCTTTTACTGTCATCATTTCTCTTGTTTT
ATTATTATTATCAATGTTTATCTATTTTTCAATTAATTTAATACAGTTTCTAATGTGAAAGACATTTTTCTGGAACCCGTTTTCCCCTTA
AACACTAAAGAGACCTCAAGTGAAAGCATATTGCTTAGTAGGAAGGTAGAAAATGTTAATCCCTGCGATTCTTTGAGTTTTAATGACAGG
GTCATTTTCAGTAAAGGAAATGCTCACCAACACATAGTCACCAACTATTAAAGGAATCATGTGATTGGATTTTCCCCTGTATACATGTAC
CCTTGGTCATAATCCCACTATTTCATACATATTTATGCATTGCTAGATTTTCCTAGGACTCCAATAGCATGCTTTCCAAGTGTTATTATT
CCCTTAATGTTAAAGAAAAAAATCAATATATTGAATTCTTTAATTAAATAGGTAAGCAGTATTAAATCATCCACAGAGATAAACAATCTC
TTGAAACTCTTTTGAAAGAGAAAAGTGTTTGTTCACTTTCATTGCCTTCATTAAGATCTCCAAATACTCAGAGACTAAGCAGGCTATTCT
CATCTCTTTGAGTTTCCTGACAGAACTAAAGGAAGGAATCACTCTTCAAAAGATGGATCTCACTTCACTCTGAAAATGTGCCTTTTTTTA
ATTGGGTGTTTAGCATAAAAATCACTATTGGGGATCTTACAGATGTCTGTTGTAGATCTATTACAATGAGGTGACTTAGACATTGGGCTT
TACCATATTAGAGAATTACTTAAGCCATTGTCCTTCAAATGTTGGGCTTGGAGACAGAAGTACCTTGGACTGAATTGCTTTCAAGTCTCT
AGAATCACTGACAGCACATAGCTTCTATGAGGAGTTATATATGAAATACCACTTGTGTCCCTCCTCAAGTTCTCTGACCACCTTCACATC
CTGCGGCCACCAACACTGTATGGATACAATCTGGCCTCTCAGCTCTGCTCACTTTCACTTTCTGTTCTGGGGATTCTCTGATACTAATTT
TGGCTACTTGGTAGAACCAAGAGACAAATCGCTTACATGCTGCAAACCGATGTGAAGGTGTTACTAACCCGCTAAAACACAATTAATGAA
AGACTGTAGCAGGTAACTGATCTTTCCCTCAGATATTCTACATGGTCCATGGAAGACTCTGTGGGCCGCAGAAGCCCATAGCTGCATACC
CTTCTATTTTCCTCTTCCCCATTTCACTCTTTTAAGCTCCCTACTCCTATTCCCTATGATCACTTTCCAAAATAAACGGCAGGTGTGCTA
GCTGTTGTCTTAGACTCTGCTTTCTGGAAACTATTTTTCCCCTCCACAAGAAATTATCACTGTGAATATTACAGGAGGAGAAATAAAATA

>77978_77978_1_RPS6-DPP10_RPS6_chr9_19380187_ENST00000380381_DPP10_chr2_116066814_ENST00000410059_length(amino acids)=778AA_BP=2
MKELGSNSPPQRNWKGIAIALLVILVVCSLITMSVILLTPDELTNSSETRLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGHVIKLNI
ETNATTLLLENTTFVTFKASRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVEDSVLQYAAWGVQGQQLIYIFEN
NIYYQPDIKSSSLRLTSSGKEEIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSLVPTMVIPRFTGALYPKGKQYPYPKAGQV
NPTIKLYVVNLYGPTHTLELMPPDSFKSREYYITMVKWVSNTKTVVRWLNRAQNISILTVCETTTGACSKKYEMTSDTWLSQQNEEPVFS
RDGSKFFMTVPVKQGGRGEFHHVAMFLIQSKSEQITVRHLTSGNWEVIKILAYDETTQKIYFLSTESSPRGRQLYSASTEGLLNRQCISC
NFMKEQCTYFDASFSPMNQHFLLFCEGPRVPVVSLHSTDNPAKYFILESNSMLKEAILKKKIGKPEIKILHIDDYELPLQLSLPKDFMDR
NQYALLLIMDEEPGGQLVTDKFHIDWDSVLIDMDNVIVARFDGRGSGFQGLKILQEIHRRLGSVEVKDQITAVKFLLKLPYIDSKRLSIF
GKGYGGYIASMILKSDEKLFKCGSVVAPITDLKLYASAFSERYLGMPSKEESTYQAASVLHNVHGLKEENILIIHGTADTKVHFQHSAEL

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>77978_77978_2_RPS6-DPP10_RPS6_chr9_19380187_ENST00000380394_DPP10_chr2_116066814_ENST00000410059_length(transcript)=5803nt_BP=65nt
GCTAAGCGGAAGTTGGCCCTCTTTTCCGTGGCGCCTCGGAGGCGTTCAGCTGCTTCAAGATGAAGGAACTGGGAAGTAACAGCCCTCCAC
AGAGAAACTGGAAGGGAATTGCTATTGCTCTGCTGGTGATTTTAGTTGTATGCTCACTCATCACTATGTCAGTCATCCTCTTAACCCCAG
ATGAACTCACAAATTCGTCAGAAACCAGATTGTCTTTGGAAGACCTCTTTAGGAAAGACTTTGTGCTTCACGATCCAGAGGCTCGGTGGA
TCAATGATACAGATGTGGTGTATAAAAGCGAGAATGGACATGTCATTAAACTGAATATAGAAACAAATGCTACCACATTATTATTGGAAA
ACACAACTTTTGTAACCTTCAAAGCATCAAGACATTCAGTTTCACCAGATTTAAAATATGTCCTTCTGGCATATGATGTCAAACAGATTT
TTCATTATTCGTATACTGCTTCATATGTGATTTACAACATACACACTAGGGAAGTTTGGGAGTTAAATCCTCCAGAAGTAGAGGACTCCG
TCTTGCAGTACGCGGCCTGGGGTGTCCAAGGGCAGCAGCTGATTTATATTTTTGAAAATAATATCTACTATCAACCTGATATAAAGAGCA
GTTCATTGCGACTGACATCTTCTGGAAAAGAAGAAATAATTTTTAATGGGATTGCTGACTGGTTATATGAAGAGGAACTCCTGCATTCTC
ACATCGCCCACTGGTGGTCACCAGATGGAGAAAGACTTGCCTTCCTGATGATAAATGACTCTTTGGTACCCACCATGGTTATCCCTCGGT
TTACTGGAGCGTTGTATCCCAAAGGAAAGCAGTATCCGTATCCTAAGGCAGGTCAAGTGAACCCAACAATAAAATTATATGTTGTAAACC
TGTATGGACCAACTCACACTTTGGAGCTCATGCCACCTGACAGCTTTAAATCAAGAGAATACTATATCACTATGGTTAAATGGGTAAGCA
ATACCAAGACTGTGGTAAGATGGTTAAACCGAGCTCAGAACATCTCCATCCTCACAGTCTGTGAGACCACTACAGGTGCTTGTAGTAAAA
AATATGAGATGACATCAGATACGTGGCTCTCTCAGCAGAATGAGGAGCCCGTGTTTTCTAGAGACGGCAGCAAATTCTTTATGACAGTGC
CTGTTAAGCAAGGGGGACGTGGAGAATTTCACCACGTAGCTATGTTCCTCATCCAGAGTAAAAGTGAGCAAATTACCGTGCGGCATCTGA
CATCAGGAAACTGGGAAGTGATAAAGATCTTGGCATACGATGAAACTACTCAAAAAATTTACTTTCTGAGCACTGAATCTTCTCCCAGAG
GAAGGCAGCTGTACAGTGCTTCTACTGAAGGATTATTGAATCGCCAATGCATTTCATGTAATTTCATGAAAGAACAATGTACATATTTTG
ATGCCAGTTTTAGTCCCATGAATCAACATTTCTTATTATTCTGTGAAGGTCCAAGGGTCCCAGTGGTCAGCCTACATAGTACGGACAACC
CAGCAAAATATTTTATATTGGAAAGCAATTCTATGCTGAAGGAAGCTATCCTGAAGAAGAAGATAGGAAAGCCAGAAATTAAAATCCTTC
ATATTGACGACTATGAACTTCCTTTACAGTTGTCCCTTCCCAAAGATTTTATGGACCGAAACCAGTATGCTCTTCTGTTAATAATGGATG
AAGAACCAGGAGGCCAGCTGGTTACAGATAAGTTCCATATTGACTGGGATTCCGTACTCATTGACATGGATAATGTCATTGTAGCAAGAT
TTGATGGCAGAGGAAGTGGATTCCAGGGTCTGAAAATTTTGCAGGAGATTCATCGAAGATTAGGTTCAGTAGAAGTAAAGGACCAAATAA
CAGCTGTGAAATTTTTGCTGAAACTGCCTTACATTGACTCCAAAAGATTAAGCATTTTTGGAAAGGGTTATGGTGGCTATATTGCATCAA
TGATCTTAAAATCAGATGAAAAGCTTTTTAAATGTGGATCCGTGGTTGCACCTATCACAGACTTGAAATTGTATGCCTCAGCTTTCTCTG
AAAGATACCTTGGGATGCCATCTAAGGAAGAAAGCACTTACCAGGCAGCCAGTGTGCTACATAATGTTCATGGCTTGAAAGAAGAAAATA
TATTAATAATTCATGGAACTGCTGACACAAAAGTTCATTTCCAACACTCAGCAGAATTAATCAAGCACCTAATAAAAGCTGGAGTGAATT
ATACTATGCAGGTCTACCCAGATGAAGGTCATAACGTATCTGAGAAGAGCAAGTATCATCTCTACAGCACAATCCTCAAATTCTTCAGTG
ATTGTTTGAAGGAAGAAATATCTGTGCTACCACAGGAACCAGAAGAAGATGAATAATGGACTGTATTTATACAGAACTGAAGGGAATATT
GAGGCTCAATGAAACCTGACAAAGAGACTGTAATATTGTAGTTGCTCCAGAATGTCAAGGGCAGCTTACGGAGATGTCACTGGAGCAGCA
CGCTCAGAGACAGTGAACTAGCATTTGAATACACAAGTCCAAGTCTACTGTGTTGCTAGGGGTGCAGAACCCGTTTCTTTGTATGAGAGA
GGTCAAAGGGTTGGTTTCCTGGGAGAAATTAGTTTTGCATTAAAGTAGGAGTAGTGCATGTTTTCTTCTGTTATCCCCCTGTTTGTTCTG
TAACTAGTTGCTCTCATTTTAATTTCACTGGCCACCATCATCTTTGCATATAATGCACAATCTATCATCTGTCCTACAGTCCCTGATCTT
TCATGGCTGAGCTGCAATCTAACACTTTACTGTACCTTTATAATAAGTGCAATTCTTTCATTGTCTATTATTATGCTTAAGAAAATATTC
AGTTAATAAAAAACAGAGTATTTTATGTAATTTCTGTTTTTAAAAAGACATTATTAAATGGGTCAAAGGACATATAGAAATGTGGATTTC
AGCACCTTCCAAAGTTCAGCCAGTTATCAGTAGATACAATATCTTTAAATGAACACACGAGTGTATGTCTCACAATATATATACACAAGT
GTGCATATACAGTTAATGAAACTATCTTTAAATGTTATTCATGCTATAAAGAGTAAACGTTTGATGAATTAGAAGAGATGCTCTTTTCCA
AGCTATAATGGATGCTTTGTTTAATGAGCCAAATATGATGAAACATTTTTTCCAATTCAAATTCTAGCTATTGCTTTCCTATAAATGTTT
GGGTTGTGTTTGGTATTGTTTTTAGTGGTTAATAGTTTTCCAGTTGCATTTAATTTTTTGAATATGATACCTTGTCACATGTAAATTAGA
TACTTAAATATTAAATTATAGTTTCTGATAAAGAAATTTTGTTAACAATGCAATGCCACTGAGTGCTATTTTGCTCTTTTGGTGGAGAAG
GCTTTTTTCAAAACTCTTGGTCCTTTTACTTCTTTCTCTCAGTGCAGAATCAATTCTCATTTTCATCGTAAAAGCAAATAGCTGGATTAT
TTCATTTGCCAGTTTCTATTTAGTATTCCATGCCTGCCCAATTCATCTGTTACTGTTTAATTTCAATTCTTCTGGTGAGAATTAGAAATG
AAATATTTTTTATTCATTGGCCAAAAAGTTCACAGACAGCAGTGTTTGCTATTTACTTTGAATTGAAGGCACAAAATGCATCAATTCCTG
TGCTGTGTTGACTTGCAGTAGTAAGTAACTGAGAGCATAAAATAAACCTGACTGTATGAAGTCAATTTAAGTGATGAGAACATTTAACTT
TGGTGACTAAAGTCAGAATATCTTCTCACTTCACTTAAGGGATCTTCCAGAAGATATCTAAAAGTCTGTAATAAGCTTAGAAGTTCAGAT
AAATCTAGGCAGGATACTGCATTTTTGTGGTTTTAAAAAAGTCCTTAGGACAGACTGAATTATCATAACTTATGGCATCAGGAGGAAACT
TTAAAATATCAAGGAATCACTCAGTCACCCTCCTGTTTTGTTGAAGGATCAACCCCAAATTCTGGGTATTTGAGTACATGTGAATCATGG
ATTTGGTATTCAACTTTTTCCCTGGATGCTTTGGAATCGTGTCTTCCATGCTCCACTGGGTTCAATTTAAAATAGGAGAGGCTTTCTCTT
CTGAAAGATCCATTTTAGGTCTTTTTCAAGAATAGTGAACACATTTTTTAACAAAATAAGTTGTAATTTTAAAAGGAAAGTTTTGCCTAT
TTTATTAAGATGGAAATTTCTTTTTAGGCTAATTTGAAATCCAACTGAAGCTTTTTAACCAATATTTTAAATTTGAACCACTAGAGTTTT
TTATGATGCAAATGATTATGTTGTCTGAAAGGTGTGGTTTTATTGAATGTCTATTTGAGTATCATTTAAAAAGTATTTGCCTTTTACTGT
CATCATTTCTCTTGTTTTATTATTATTATCAATGTTTATCTATTTTTCAATTAATTTAATACAGTTTCTAATGTGAAAGACATTTTTCTG
GAACCCGTTTTCCCCTTAAACACTAAAGAGACCTCAAGTGAAAGCATATTGCTTAGTAGGAAGGTAGAAAATGTTAATCCCTGCGATTCT
TTGAGTTTTAATGACAGGGTCATTTTCAGTAAAGGAAATGCTCACCAACACATAGTCACCAACTATTAAAGGAATCATGTGATTGGATTT
TCCCCTGTATACATGTACCCTTGGTCATAATCCCACTATTTCATACATATTTATGCATTGCTAGATTTTCCTAGGACTCCAATAGCATGC
TTTCCAAGTGTTATTATTCCCTTAATGTTAAAGAAAAAAATCAATATATTGAATTCTTTAATTAAATAGGTAAGCAGTATTAAATCATCC
ACAGAGATAAACAATCTCTTGAAACTCTTTTGAAAGAGAAAAGTGTTTGTTCACTTTCATTGCCTTCATTAAGATCTCCAAATACTCAGA
GACTAAGCAGGCTATTCTCATCTCTTTGAGTTTCCTGACAGAACTAAAGGAAGGAATCACTCTTCAAAAGATGGATCTCACTTCACTCTG
AAAATGTGCCTTTTTTTAATTGGGTGTTTAGCATAAAAATCACTATTGGGGATCTTACAGATGTCTGTTGTAGATCTATTACAATGAGGT
GACTTAGACATTGGGCTTTACCATATTAGAGAATTACTTAAGCCATTGTCCTTCAAATGTTGGGCTTGGAGACAGAAGTACCTTGGACTG
AATTGCTTTCAAGTCTCTAGAATCACTGACAGCACATAGCTTCTATGAGGAGTTATATATGAAATACCACTTGTGTCCCTCCTCAAGTTC
TCTGACCACCTTCACATCCTGCGGCCACCAACACTGTATGGATACAATCTGGCCTCTCAGCTCTGCTCACTTTCACTTTCTGTTCTGGGG
ATTCTCTGATACTAATTTTGGCTACTTGGTAGAACCAAGAGACAAATCGCTTACATGCTGCAAACCGATGTGAAGGTGTTACTAACCCGC
TAAAACACAATTAATGAAAGACTGTAGCAGGTAACTGATCTTTCCCTCAGATATTCTACATGGTCCATGGAAGACTCTGTGGGCCGCAGA
AGCCCATAGCTGCATACCCTTCTATTTTCCTCTTCCCCATTTCACTCTTTTAAGCTCCCTACTCCTATTCCCTATGATCACTTTCCAAAA
TAAACGGCAGGTGTGCTAGCTGTTGTCTTAGACTCTGCTTTCTGGAAACTATTTTTCCCCTCCACAAGAAATTATCACTGTGAATATTAC

>77978_77978_2_RPS6-DPP10_RPS6_chr9_19380187_ENST00000380394_DPP10_chr2_116066814_ENST00000410059_length(amino acids)=778AA_BP=2
MKELGSNSPPQRNWKGIAIALLVILVVCSLITMSVILLTPDELTNSSETRLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGHVIKLNI
ETNATTLLLENTTFVTFKASRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVEDSVLQYAAWGVQGQQLIYIFEN
NIYYQPDIKSSSLRLTSSGKEEIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSLVPTMVIPRFTGALYPKGKQYPYPKAGQV
NPTIKLYVVNLYGPTHTLELMPPDSFKSREYYITMVKWVSNTKTVVRWLNRAQNISILTVCETTTGACSKKYEMTSDTWLSQQNEEPVFS
RDGSKFFMTVPVKQGGRGEFHHVAMFLIQSKSEQITVRHLTSGNWEVIKILAYDETTQKIYFLSTESSPRGRQLYSASTEGLLNRQCISC
NFMKEQCTYFDASFSPMNQHFLLFCEGPRVPVVSLHSTDNPAKYFILESNSMLKEAILKKKIGKPEIKILHIDDYELPLQLSLPKDFMDR
NQYALLLIMDEEPGGQLVTDKFHIDWDSVLIDMDNVIVARFDGRGSGFQGLKILQEIHRRLGSVEVKDQITAVKFLLKLPYIDSKRLSIF
GKGYGGYIASMILKSDEKLFKCGSVVAPITDLKLYASAFSERYLGMPSKEESTYQAASVLHNVHGLKEENILIIHGTADTKVHFQHSAEL

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Top

Fusion Gene PPI Analysis for RPS6-DPP10

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for RPS6-DPP10

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for RPS6-DPP10

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source