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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RPS6KA2-FGFR1OP (FusionGDB2 ID:77989)

Fusion Gene Summary for RPS6KA2-FGFR1OP

check button Fusion gene summary
Fusion gene informationFusion gene name: RPS6KA2-FGFR1OP
Fusion gene ID: 77989
HgeneTgene
Gene symbol

RPS6KA2

FGFR1OP

Gene ID

6196

11116

Gene nameribosomal protein S6 kinase A2centrosomal protein 43
SynonymsHU-2|MAPKAPK1C|RSK|RSK3|S6K-alpha|S6K-alpha2|p90-RSK3|p90RSK2|pp90RSK3FGFR1OP|FOP
Cytomap

6q27

6q27

Type of geneprotein-codingprotein-coding
Descriptionribosomal protein S6 kinase alpha-2MAP kinase-activated protein kinase 1cMAPK-activated protein kinase 1cMAPKAP kinase 1Cmitogen-activated protein kinase-activated protein kinase 1Cribosomal S6 kinase 3ribosomal protein S6 kinase, 90kDa, polypeptideFGFR1 oncogene partnerfibroblast growth factor receptor 1 oncogene partner
Modification date2020031320200313
UniProtAcc.

Q9NVK5

Ensembl transtripts involved in fusion geneENST00000503859, ENST00000510118, 
ENST00000265678, ENST00000366863, 
ENST00000405189, ENST00000481261, 
ENST00000509742, 		ENST00000476078, 
ENST00000349556, ENST00000366847, 
Fusion gene scores* DoF score9 X 9 X 5=4054 X 4 X 4=64
# samples 104
** MAII scorelog2(10/405*10)=-2.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPS6KA2 [Title/Abstract] AND FGFR1OP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRPS6KA2(167271688)-FGFR1OP(167424301), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPS6KA2

GO:0008285

negative regulation of cell proliferation

16878154

HgeneRPS6KA2

GO:0043065

positive regulation of apoptotic process

16878154

HgeneRPS6KA2

GO:0045786

negative regulation of cell cycle

16878154

TgeneFGFR1OP

GO:0006469

negative regulation of protein kinase activity

17888034

TgeneFGFR1OP

GO:0008284

positive regulation of cell proliferation

17888034

TgeneFGFR1OP

GO:0030307

positive regulation of cell growth

17888034

TgeneFGFR1OP

GO:0030335

positive regulation of cell migration

17888034


check buttonFusion gene breakpoints across RPS6KA2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FGFR1OP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A06R-01ARPS6KA2chr6

167271688

-FGFR1OPchr6

167424301

+


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Fusion Gene ORF analysis for RPS6KA2-FGFR1OP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000503859ENST00000476078RPS6KA2chr6

167271688

-FGFR1OPchr6

167424301

+
5CDS-intronENST00000510118ENST00000476078RPS6KA2chr6

167271688

-FGFR1OPchr6

167424301

+
In-frameENST00000503859ENST00000349556RPS6KA2chr6

167271688

-FGFR1OPchr6

167424301

+
In-frameENST00000503859ENST00000366847RPS6KA2chr6

167271688

-FGFR1OPchr6

167424301

+
In-frameENST00000510118ENST00000349556RPS6KA2chr6

167271688

-FGFR1OPchr6

167424301

+
In-frameENST00000510118ENST00000366847RPS6KA2chr6

167271688

-FGFR1OPchr6

167424301

+
intron-3CDSENST00000265678ENST00000349556RPS6KA2chr6

167271688

-FGFR1OPchr6

167424301

+
intron-3CDSENST00000265678ENST00000366847RPS6KA2chr6

167271688

-FGFR1OPchr6

167424301

+
intron-3CDSENST00000366863ENST00000349556RPS6KA2chr6

167271688

-FGFR1OPchr6

167424301

+
intron-3CDSENST00000366863ENST00000366847RPS6KA2chr6

167271688

-FGFR1OPchr6

167424301

+
intron-3CDSENST00000405189ENST00000349556RPS6KA2chr6

167271688

-FGFR1OPchr6

167424301

+
intron-3CDSENST00000405189ENST00000366847RPS6KA2chr6

167271688

-FGFR1OPchr6

167424301

+
intron-3CDSENST00000481261ENST00000349556RPS6KA2chr6

167271688

-FGFR1OPchr6

167424301

+
intron-3CDSENST00000481261ENST00000366847RPS6KA2chr6

167271688

-FGFR1OPchr6

167424301

+
intron-3CDSENST00000509742ENST00000349556RPS6KA2chr6

167271688

-FGFR1OPchr6

167424301

+
intron-3CDSENST00000509742ENST00000366847RPS6KA2chr6

167271688

-FGFR1OPchr6

167424301

+
intron-intronENST00000265678ENST00000476078RPS6KA2chr6

167271688

-FGFR1OPchr6

167424301

+
intron-intronENST00000366863ENST00000476078RPS6KA2chr6

167271688

-FGFR1OPchr6

167424301

+
intron-intronENST00000405189ENST00000476078RPS6KA2chr6

167271688

-FGFR1OPchr6

167424301

+
intron-intronENST00000481261ENST00000476078RPS6KA2chr6

167271688

-FGFR1OPchr6

167424301

+
intron-intronENST00000509742ENST00000476078RPS6KA2chr6

167271688

-FGFR1OPchr6

167424301

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000510118RPS6KA2chr6167271688-ENST00000366847FGFR1OPchr6167424301+139614641941225343
ENST00000510118RPS6KA2chr6167271688-ENST00000349556FGFR1OPchr6167424301+15054641941165323
ENST00000503859RPS6KA2chr6167271688-ENST00000366847FGFR1OPchr6167424301+1400150491265418
ENST00000503859RPS6KA2chr6167271688-ENST00000349556FGFR1OPchr6167424301+154550491205398

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000510118ENST00000366847RPS6KA2chr6167271688-FGFR1OPchr6167424301+0.0003302970.9996697
ENST00000510118ENST00000349556RPS6KA2chr6167271688-FGFR1OPchr6167424301+0.001164150.99883586
ENST00000503859ENST00000366847RPS6KA2chr6167271688-FGFR1OPchr6167424301+0.0003304650.99966955
ENST00000503859ENST00000349556RPS6KA2chr6167271688-FGFR1OPchr6167424301+0.0010273220.99897265

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Fusion Genomic Features for RPS6KA2-FGFR1OP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RPS6KA2chr6167271687-FGFR1OPchr6167424300+5.99E-070.9999994
RPS6KA2chr6167271687-FGFR1OPchr6167424300+5.99E-070.9999994

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RPS6KA2-FGFR1OP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:167271688/chr6:167424301)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FGFR1OP

Q9NVK5

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May be involved in wound healing pathway. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRPS6KA2chr6:167271688chr6:167424301ENST00000265678-121319_3880734.0DomainAGC-kinase C-terminal
HgeneRPS6KA2chr6:167271688chr6:167424301ENST00000265678-121415_6720734.0DomainProtein kinase 2
HgeneRPS6KA2chr6:167271688chr6:167424301ENST00000265678-12159_3180734.0DomainProtein kinase 1
HgeneRPS6KA2chr6:167271688chr6:167424301ENST00000503859-222319_38841742.0DomainAGC-kinase C-terminal
HgeneRPS6KA2chr6:167271688chr6:167424301ENST00000503859-222415_67241742.0DomainProtein kinase 2
HgeneRPS6KA2chr6:167271688chr6:167424301ENST00000503859-22259_31841742.0DomainProtein kinase 1
HgeneRPS6KA2chr6:167271688chr6:167424301ENST00000265678-121421_4290734.0Nucleotide bindingATP
HgeneRPS6KA2chr6:167271688chr6:167424301ENST00000265678-12165_730734.0Nucleotide bindingATP
HgeneRPS6KA2chr6:167271688chr6:167424301ENST00000503859-222421_42941742.0Nucleotide bindingATP
HgeneRPS6KA2chr6:167271688chr6:167424301ENST00000503859-22265_7341742.0Nucleotide bindingATP
TgeneFGFR1OPchr6:167271688chr6:167424301ENST0000034955641270_102146380.0DomainLisH
TgeneFGFR1OPchr6:167271688chr6:167424301ENST0000036684741370_102146400.0DomainLisH


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Fusion Gene Sequence for RPS6KA2-FGFR1OP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>77989_77989_1_RPS6KA2-FGFR1OP_RPS6KA2_chr6_167271688_ENST00000503859_FGFR1OP_chr6_167424301_ENST00000349556_length(transcript)=1545nt_BP=504nt
AATTCGAAGCTGCAAGTGCAGCGTTTACTCTGCCAAAGTCGCAGTACAGATTCCGAAGCCGCAGCGCCGTCCCCTCCTTTCCTCGCCCCA
GCCCGAGCGGGAAGCGGCAGCAGCTCCCCAGAGCCCTGGCTTGGCAGGGAGGGGACGGCGCCCGAGCAGCCATATTGCAGCCCCCCGGGT
CCCTCCTCCGGCCGGCGCAGGCCCCGCGCTCACGACCTCCTCTGGGAGCCGGATCTGTCCTCTCCATCGCCGCCACCCGCCGGCCTCTGC
GTCCCTTGGCTTCCGACATCCCGTCTGGCCGTCCCCCTGTGCCGGTCCGAGCCTCTGTTTATTTCCTTTCCTACTATCAATACTCGACCA
GCAGAAAAGGAAAGTTTAAAAATGCCAATCGCACAGTTGCTGGAACTATGGAAAAAGATCGAGGTGGAGCCTATGGAAATAGAGACCACA
GAGGAGGATCTCAACCTGGATGTGGAGCCCACCACAGAAGACACTGCAGAAGAAGGTGCACTTGATCTATCTGATGTACATTCTCCACCA
AAGTCACCAGAGGGAAAAACAAGTGCACAGACAACACCAAGTAAGAAGGCCAATGATGAGGCCAATCAGAGTGATACAAGTGTCTCCTTG
TCAGAACCCAAGAGCAAAAGCAGCCTTCACTTACTGTCCCATGAAACAAAAATTGGATCTTTTCTAAGCAACAGAACTTTAGATGGCAAA
GACAAAGCTGGCCTTTGTCCAGATGAAGATGATATGGAAGGAGATTCTTTCTTTGATGATCCCATTCCTAAGCCAGAGAAAACTTACGGT
TTGAGGAAGGAACCTAGGAAGCAAGCAGGAAGTCTGGCCTCGCTCTCGGATGCACCCCCCTTAAAAAGTGGACTCAGCTCCCTGGCGGGA
GCCCCTTCTTTAAAAGACTCTGAGAGTAAAAGGGGAAATACAGTTTTGAAAGATCTGAAATTGATCAGTGATAAAATTGGATCACTTGGA
TTAGGAACTGGAGAAGATGATGACTATGTTGATGATTTTAATAGTACCAGCCATCGCTCAGAGAAAAGTGAGATAAGTATTGGTGAAGAG
ATAGAAGAAGACCTTTCTGTGGAAATAGATGACATCAATACCAGTGATAAGCTTGATGACCTCACACAAGATCTGACTGTATCCCAGCTC
AGTGATGTTGCGGATTATCTGGAAGATGTTGCATAGACACGAAGAAGGAAGTATTCTAATTAACAAGGACAGAGGACTGACCGGTTCCAT
TTTTTTTTTTTCCAGACAATCACTCAGCTGGAATGTCTGCTCTCTATTGGTGCCTTGCATTTCAAAAACACTGCAGATATTTTTTAAAAG
TAATTTTCATTTTACTAAACAAAATACTTCCTATTTGAGCCCATGTGTGGAAGATTTAATATTCTTAATTTAACTGTACATTTCTTTATG
GAAATTGATTATCTACACTCAGTTTCATTACAGGGAAGGAACCCATGAAAACATCAGTGTTAAGAGCATGATGAAAGGTGTCAATAAAGC

>77989_77989_1_RPS6KA2-FGFR1OP_RPS6KA2_chr6_167271688_ENST00000503859_FGFR1OP_chr6_167424301_ENST00000349556_length(amino acids)=398AA_BP=165
MQVQRLLCQSRSTDSEAAAPSPPFLAPARAGSGSSSPEPWLGREGTAPEQPYCSPPGPSSGRRRPRAHDLLWEPDLSSPSPPPAGLCVPW
LPTSRLAVPLCRSEPLFISFPTINTRPAEKESLKMPIAQLLELWKKIEVEPMEIETTEEDLNLDVEPTTEDTAEEGALDLSDVHSPPKSP
EGKTSAQTTPSKKANDEANQSDTSVSLSEPKSKSSLHLLSHETKIGSFLSNRTLDGKDKAGLCPDEDDMEGDSFFDDPIPKPEKTYGLRK
EPRKQAGSLASLSDAPPLKSGLSSLAGAPSLKDSESKRGNTVLKDLKLISDKIGSLGLGTGEDDDYVDDFNSTSHRSEKSEISIGEEIEE

--------------------------------------------------------------
>77989_77989_2_RPS6KA2-FGFR1OP_RPS6KA2_chr6_167271688_ENST00000503859_FGFR1OP_chr6_167424301_ENST00000366847_length(transcript)=14001nt_BP=504nt
AATTCGAAGCTGCAAGTGCAGCGTTTACTCTGCCAAAGTCGCAGTACAGATTCCGAAGCCGCAGCGCCGTCCCCTCCTTTCCTCGCCCCA
GCCCGAGCGGGAAGCGGCAGCAGCTCCCCAGAGCCCTGGCTTGGCAGGGAGGGGACGGCGCCCGAGCAGCCATATTGCAGCCCCCCGGGT
CCCTCCTCCGGCCGGCGCAGGCCCCGCGCTCACGACCTCCTCTGGGAGCCGGATCTGTCCTCTCCATCGCCGCCACCCGCCGGCCTCTGC
GTCCCTTGGCTTCCGACATCCCGTCTGGCCGTCCCCCTGTGCCGGTCCGAGCCTCTGTTTATTTCCTTTCCTACTATCAATACTCGACCA
GCAGAAAAGGAAAGTTTAAAAATGCCAATCGCACAGTTGCTGGAACTATGGAAAAAGATCGAGGTGGAGCCTATGGAAATAGAGACCACA
GAGGAGGATCTCAACCTGGATGTGGAGCCCACCACAGAAGACACTGCAGAAGAAGGTGCACTTGATCTATCTGATGTACATTCTCCACCA
AAGTCACCAGAGGGAAAAACAAGTGCACAGACAACACCAAGTAAGATACCAAGGTATAAAGGACAAGGTAAGAAGAAGACAAGCGGGCAG
AAGGCTGGTGACAAGAAGGCCAATGATGAGGCCAATCAGAGTGATACAAGTGTCTCCTTGTCAGAACCCAAGAGCAAAAGCAGCCTTCAC
TTACTGTCCCATGAAACAAAAATTGGATCTTTTCTAAGCAACAGAACTTTAGATGGCAAAGACAAAGCTGGCCTTTGTCCAGATGAAGAT
GATATGGAAGGAGATTCTTTCTTTGATGATCCCATTCCTAAGCCAGAGAAAACTTACGGTTTGAGGAAGGAACCTAGGAAGCAAGCAGGA
AGTCTGGCCTCGCTCTCGGATGCACCCCCCTTAAAAAGTGGACTCAGCTCCCTGGCGGGAGCCCCTTCTTTAAAAGACTCTGAGAGTAAA
AGGGGAAATACAGTTTTGAAAGATCTGAAATTGATCAGTGATAAAATTGGATCACTTGGATTAGGAACTGGAGAAGATGATGACTATGTT
GATGATTTTAATAGTACCAGCCATCGCTCAGAGAAAAGTGAGATAAGTATTGGTGAAGAGATAGAAGAAGACCTTTCTGTGGAAATAGAT
GACATCAATACCAGTGATAAGCTTGATGACCTCACACAAGATCTGACTGTATCCCAGCTCAGTGATGTTGCGGATTATCTGGAAGATGTT
GCATAGACACGAAGAAGGAAGTATTCTAATTAACAAGGACAGAGGACTGACCGGTTCCATTTTTTTTTTTTCCAGACAATCACTCAGCTG
GAATGTCTGCTCTCTATTGGTGCCTTGCATTTCAAAAACACTGCAGATATTTTTTAAAAGTAATTTTCATTTTACTAAACAAAATACTTC
CTATTTGAGCCCATGTGTGGAAGATTTAATATTCTTAATTTAACTGTACATTTCTTTATGGAAATTGATTATCTACACTCAGTTTCATTA
CAGGGAAGGAACCCATGAAAACATCAGTGTTAAGAGCATGATGAAAGGTGTCAATAAAGCCGTAGGATCGCGCAACCCTTTGTGTGTGTG
GCTGCTGGTACGTGTGATCTTTGAAAACCTTGGCTTTAGCCCTCTGGAATCAGAGCTTACCCACCATAGTATATTTTGATATTAGGTGGT
TCTACACATAGTTGGCAAAATGACTTGGTAAATTTGTAATGCTGAAGTATATTAGTATAAGTTAAATTTGATGTGTCAACTTTATTTTGT
ATTTCCTTCCATTTGGAAGGTTTGTTAGACCATTAAGGTTATATTAAAGTACTCTTGTGTGTGCTATTTAGTTTTGCTTGTTTTAAAGAA
ATCTAGAAGTGGTTATGAGTTTTAATTCATAGAATTGTCAATAACATAACATTTGCAATCGTCATTCCTCCTGTTATCCATGTAAGCAGC
TTTAGTCGTAGGTTCTCTTCATTATAATTTATTATCTGTAAAGATTCCTTGAAACTTAAATGCATCTGAAACCATTAAGCAGTGCTTTTA
TTTCAGATCTGTAAGTTAATTGTATTAAAATCCAAATTGGAATGAAATAGTAGTAATGGCCTAAGACCATGTTCAGTTTGACAAGCTTTA
TATACTGTACATAATTTCATTGTAACCCTTAAAAATAGAGCCAATAATAGAATTTCCACAGTCTCATTTATACGGTTAAAGCATTATTGC
TATTATGTAGGTCACGGATGTTTATAATACTAAAGTATTTTAAAATGTGCAAGTAGAAAAAACAGTAGAAAGTGATGCATGCATATTTAT
ATATAAGTAAAGCAGGATTGTGCTGTTTTTGCACTTTATAATTTCAATTAAGTTGCGGCTTTTTACTACAAGTTAACTTTATTAGTAAAA
GGAGCAAATTAGACCTAATTCATTGATCTCGGTTAAGTGAGCAGACTGCATGACTTGTGTAATGCCAGTTTCTCATTTCATATTAGCCTA
AATATTACAGAAATTACTCCTTGGGCTCTAAAATGTAGAGGAAATGAAAATGTAAGGATTAAGGCTGTGTAACAGAATCTGGCTTTTTAA
AATTTAAGTGAAACTAAGCTGTAAACATCAAGAGGAAGTAGGACATAAACTGGGCCGGTACAGCCTGGGAGCCCTGTGTATTTCTGCCCT
CCGTCTGTGAGCTGCTATCTCAGTCTCCTTCAGCTCTTCATGTCTTAGTAAACAGCACCACGTGCAGATGTAATCTTGTTGCAGTCCCCC
AGTGTGGTTGTTATAAAATGCATTTCTTTGTAAGTCATCTCTGTAAACAGTCACTTTCTAAAAGCACTATAGTTCTGGTCCCCTGGAATC
TGGATCACATGTATGATTTATTTTTAATATTTGATAGGAACTAGGTTTCAGTGAAATGATTTGAAAGCATAGCAGGATGTGGCTTTTTAA
ATTTATGAAACTTTCGAACAGTAGCAACTGAAATTTGTCACTTTTCTGTTACGCAGAGAATCAGACCTTTTGATAATATTTGGGAGGGTA
AAAGAAATATGCCAAATATGAAACTTTTTTGTCAGCACTACATACATCTTTTTTTTGCGGGGGGCGGGGGGGACAGAGTCTCACTGTGTC
ACTCAGACTGGAGTACAGTGATGCGATCTCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCGATTCTCCTGCTTCAGCCTCCTGAGT
AGCTGGGATTACAGGTGCACACCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGTCAGGCTGGTCT
TGAACTCCTGACCTCGTTCCTGCCTTAGCCTCCTAAAGTGCCGGGATTACAGGCGTGAACCACCGCACCTGGCCAGTACTACATCCATTT
TATTGAATGATTTTGAATGACTTAAAGTTCAACTATGAAAAAGCTTTCTTTTCACATGTACTTTTTGATTAGGTATTATCAACTTATGAA
ACTTGAAGATGTGAAGTGACAGGTTTTGCATGTGATGAGTGTTTTCTGTTAAAAAATAAATATTGAAATATTAACCCATTAAATACATTT
TTATGGTAACCTATGTTTTACAGTGGAGTTTTAAAAATGCTAGGTCTTTCTTTCATTTTATTGATAACTACAAATGAATAAAAAGCATTT
ATTCTCTTTGTTGATATTCGGTTGTGCTTTTATACTTTATGTTGGATAACAACCTGTGGGCAGTTGTGTAGATGCCATTAGTCCCTGCCT
CATGCTTGCCCACAGCTCTTCCTCCCCTCCTTACTTCCCTCTCCTGCCCATGCACCAGAGCTGTGCCAGCCCACTGCTGCACAGCCTCTG
CACCTGAGCTTGCCAAAGCCCTTCCTGTCTCAAGGTGTGATATTTGCCCCTCCTTGTCTGGAATGTCCTTCCCCTAGAACTGCATGAAGC
TGGTTTATTTCAGTCTCATGTTCAAAGACGCTTCCAGACCTAAGGGAGATGTCCATTCTCCTCCCTGTCCCTGCCCCACCACTTGCATTT
ACCCCTTTTATTTTATTCATCTCAGCATACTCTGAAATGGTCTTGCTTATTTTGTGTGTGTGTGTGTGTGTGTGTGTTTAACTATGAGCT
CGTGAGAACAGGGATTTTCTTTTAAACTGCTGTGTACCTGGCACAACATTTGTCCCCTAGTATGAGCTTGGCATCTTTGGGGCTGTAAAC
AGGCTTGAGCACTGACATGGGGCCTGGAGAATGTGGTTTCTGGCTAGGCAGCTGGAACAATCTACAAAATCTGAGGGGAAAGCTGTCCTT
ACCCTAAACCTGGGGAGGTCCCTAGGTTCAAGTCTGCAGGAAGGGGATCTGGTTCAGGAGAAGGCCGTCCTGTGAATTTGCCCCACCCAC
CAAGCTCAGCTGGAGCAGGGCCTCTGAAGGAGGTGCCCTCTGTGTGGCTCTGCTGTGGTGTTGGTTCATGAAGGACATGGGAGGGGGGCA
GGACAGGAGAGGCAGCTCTTCCTGGAGAAAAACACACCCAGCCCAAGTTGGAGCCCTCCTGTGGCATTGGGTGGGGAGGATTCCCGCCAT
CAGTTCTCTGTCCATGGGTGCTAGTCTCACCCCTGCCCTCCGAGCAGTCCGTGCTCCCAGTGTCCCTGTCCTCTTTTTTTTTTTTTTTTT
TTTTTGAGGTGGAGTTTTGTTCTTGTTGCCCAGGCTGGAGTGCCATGGGGCGACCTCGGCTCACTGCAACCCCTGCCTTCTGGGTTCAAG
TGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGAGATTACAGGTGCCTGCCACCATGCCCAGCTAATTTTTATAATTTTTTTGTAGAGACG
GGATTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGAATACAGGT
GTGAGTCACGGTGCCCGGCCTAGTCTTCCTGCTCTAGGAAGGGACGTGTTTGGGGAGGAAATCCAGGGCAGCTACCTTTGTGAGTTGTCC
TAATGCTGCGTTCAGAGTTCCACACGTTCAACAAGCATCTGACATTTAAGGAAAGTGAATGTATGTCATGAAAGACAGATGAACAAAGAA
CTGATCTTGAAGAAAATGTAATCAGGAAACGAGATAATTCAAGAACAAAAACCTGTGAAGGACTGAATGTGTCCCCCAAAATGTGTATGT
CGAAACCTAATCCCACATAGGATGGAATTAGGTAGGGCCTCTGGAAGTTGATGAGATCATTAGCGCCCTTATAGGAGGCCCGGGAGAGCT
GCTTTGCCCCTTCCAGCGTGTGAGGACACAGTGAGGAGGTGTTGCCTATGAGGAAACAGGCCCTCCCAGATGGTGAACCTGCCGGTACCT
TGATCTTGGACTTAAGCCATCTGAGCTGTGAGCCCTACACTTCCATTCTTTATAAATTATCCAGTCCAAGGTACTTTAGGAACCTGAATG
GATTAAGACAAACCTGATTATGCCACTCCGAGATTTGAGGTAACATTTGAATCTAAAAGAGGCTATATGAAAGAGGTTATAATAAAAATG
ATTTTTGACTAAAAAATTGTTGGCCTAAGATAATTCAGTAGCAGGGCTGAATAATGGGATGACTCAAAATCAGTAAGCTCAAAGGCAATT
TCAAAGAAATCTTTATGTTTAGCAAGAAGACCAAGATGACAAGATGCGCCAGGAGACTTGGCCAGAGGACCTCCAGGCTGACAAAGTTTC
CCCGAGGAAGTCAGATTGGAAAAGTGTCCTCAGGTTCAAGGAAACCTGGGTGTGCACCGGGTGAATGAGAGTGGCAGACAGAAGGAAACA
GCAAGGCCTCTGAGGTAGGAGGGACAGCGTTTTTGAATGTGAAATTTATTCCCTGATACATGTTTTTAAAAATGAATCTTGCTGCCCTTA
GAAAATGAACCCCCGAACAAGGTAAGGTCGAGCTGGCCCCTCGTGTCATCCGACTTTGCGTTGTGGCCCTGCCTGCAGAAACGTGTGCTC
TGCTACAGCCCTGGGAGGAGGGGCCGGGCTCCCAACTCCTGCCCCGCTTCTAGCACATGCTGTGCTTGGCCACTTCTCTGCCTCTTAGTT
TAACAGCAGCACTGGGCAAGGTTTGCCCTCTGCACACCAGACCGGCTTCCCAAGAACCGGGGAAGAGGAGAGGGCATGCCTGGGGCCTGA
GCTTAGTGGGCCGGGTGGAGGCAGGAGGTACTGCATGGAGGAGCGTGGACAGTGGCATGCAGGAGGCCAGTCATTCTGCGGTTTTAGCTG
GAGGTTTGTTTTTGGTAGTTTGTAGAATCATCAGATTTGATGATGAAACTTTTTTTCCATAAATGTTAAATTTTCAGACACTTGTATTTT
TTTTTTCCTTTTTTTTTTTTGAGACTGAGTCACTGTCGCCCAGGCTGGAGTGCAGTGGTACTAGCTCGGCTCACTGCAACCTCTGCCTCC
CAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGATGTGTTTCACCATGCCCGGCGAATTTTTTTTGTATTTT
TAGTAGACACGGGATCTCACCGTGTTGGCCAGGCTGGTCTTGAACTCCTGACCTATGGTGATCCGCACCCCTCCCCGCCCCCCCCGCGGC
CCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGTACCCAGCCCTGTATTTTCTTTAAAAACCAATTTTGGGCCGGGCACGGT
GGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACATGGTGA
AAACCCATCTCTACTAAAAATACAGAAAAAAAATGAGCTGGGTGCGATGGTGGGTGCCTGCAGTCCCAGCTACTCGGGAGGCTGAGGCAG
GAGAATGGCGTGAACCCAGGAGGCGGAGCTTGCAGTGAGCCCAGATCACGCCCCTGCACTCCAGCCTGGGTGACAGAGCGAGACTCCGTC
TCAAAAACAACAACAACAACGAAAAAACGATTTTGGCATGTTTTGTAAGTTGCCAGACTATTGGATATACCTCTTAATCATACTTTGTTT
GAAATCCTTTGTGGTTTCTAAAGCACTAGTAGCTTTCTGAAAGGAAAATTTTTAATGAATGAAGCATGCTTCATCCTGCACATCCCCTCC
TGCCCCAGCACCCCTACTGCCCATGCGCCTCTCCTGCCCCAGCACCCCTACTGCCCCAGTGCCAGGCCTTTTCTAGCAGCTCTCATGGGT
TCATCCCTGCTGCGGGCATTGCTCCACCAAGGGGCAGTGCTCTCCCTGCCGGTAAGTGTTGGAACTTCACGTTTCCCTCTAGTTTTCTCT
TTACATTTTAACATACACTATTATGTGTCAATATATTAATTATATATTAATTACATTTATAGAGGTTAGGTATATATGGCAGATCATATC
TGAGCGTGAATTACATTCTCCAATATTTTTATTTGTCATGATTTATTGCAGGGTTCACTTATTTGATCTACCCCAACTTAACACACATTT
CCAAGAAAATATCCATCACACTAGAAAGAAAGAAAGAGGAAGGAAGGAAGGGAGGGAGGGAGAGAAGGAGAAAGGAAGAAAGGGAAGGAA
AATGGAATGGAGGAAGGGAAAAATGGAAGGAGGAAGGAAGGAAGGGAAAGAATGAAGAAAGCCATTTGTTCCTGCAAACCTAAACCTCTT
TGTAGTAAGTTCTGGCAGAAGGTGTGTTTCTGGAGTTAAACTACAGGCTTGGAAATGGAATTTCTTAGCCTAATTTCTAAATTAGAACTG
CTTATGCAAATTAACACTCCGTACATTTCAACAAGCAGTTGGCTGATTTCTTCTGTCCACTCCACCTGCAGATGCAGAGGTGGCCCCATC
CTGTGATGTGCCACCACATCCCTTTTCAGTGAAGGGCTTTGTTGGCTGCTGTGGGCATTCTCATGGCCTCTCCAGGGATGGCCTCCACTG
TAGAGACCTATGTCACCAAGGCCAGGCCCTCTCAGGGGGCTCCATCCAACGACCATTCTGCCTCAGGGTAAGAGGCCCGGCCCTCTCAGC
CTGAGTCCATTCTGGCTCCAGAGCTCCCTGAGAGCTTGCCTGGCAAGTTACTCTTGCAATTCTAGCTTCCAGCAGGCGTTGATTTCTGGG
GCACTTTTGATAAACTCCTGGCAGGAAACTCAATCTCTGGGGGTCAGAGTCCACTTCCTGGGGAGCCCAATCTGTGACCCCTAGGAGTGG
GGACCATGGAAGCACTTGGCTCTCCAGCATGTGCTGAATAGGGGGCGCTGCCTGCAATGTCCACGTGGAAACCTGGCTGGGAGAATGCCT
GTGTGCTCTGCATGGGGATGTAAAGGTGTGAGCAAACCTTCTTCAGAGAGGGGATGTTCAATGCGAAATTTGAACATTGGGACCTGAAAA
ACTGATGGGCTGATGGGGTCTGCCCATGATTGGCAGCCTTCATAGAATCACGAGGGAGGAGCACAGGCCACCCTAGACAGGAGGGGTCCC
CTACTGACAGGGAGGTGCTGTCGGGGCAGCAGGCACGTGCAGGAAAACGGAAAAGCAGAGTAATTGAATGTAAATCATGCAACTCCACTA
CAGTGGCTAGAAGCCTGGATGGGCAACTTGGCTGAGTGATGTTGGGCAAGTTATTTAATATCAGTATTCTCAGTTTTCTCATCTGTAAAG
GGGATTAAATACTTCCTTCCCTTACAGGGCTGCCCTGGTCTTAAGTAATGCCCACAGAGAGCTTAGCATTGTTCTTGGCAAGTCACTAGT
ACTCAGTAAATACTATTTTTATTAAGAAGGTAAGATTCACAGGACTTAGTGTCTTAACTAGATGTTGAGAGTAAGGAGAAGAGAGAATAC
TTCTCGGATGATTGTTCAGTTTCTGATGAATGTCTGTTCCCCTTTCAAAACCTAATTCAGATGTCACTTCCTCCTCAAAGCTCTCGCCCC
GCGCCGAGCTACTGTGATGTATTTTTATGACCTGGCAGCTTTTTTCTCATATCCCTGTTAGCGGTATGTGGTAAGAACATGAGACACAGA
ATCAGAAACCATGGATTTCTGGTCTTGACTCCACTACCACTCAGAGGAACCTCACGGTGGATGCCGTAAGTGTTTACACTGAAAAGGATT
TTCACGAAAACCTGCATTTTCATTTCGTTCACAAGAGAATTATGAGACTAGAAAAACAACAATTCTTAGTATACCACAGACTGTGGTGCC
TAGGAATAACAGACAAGCTTTAACTCACACGATGAGCATCTTTATTTAGCTCTGCTTTTAGATATCTGCATGATAAAGATGAGTGATCCA
ACGTTAGAAATCATCTGGACATTAAAACTGAATTGTAGGCAGGCGTGGTGGCTCACACCTGTAATCCCAGCACTTACGGAGACCAAGGCG
GGCAGATTGCTTGAGCTCAGGAGTTTGTGAGACTAGCCTGGGCAACATAGTAAGACCCCTATCTCTACAAAAAATATAAAAATTAGCTAG
GCATCATGGCCTGTGCCTGTAGTCCTAGCTATTGAGGAAACTGATGCAGGAGGATCATTTGAGCTCAGGAGTTTGAGACCATTCTGGGCA
ATACGGTGAAACCCTGTCTCTACAAAAAAATGCAAAGATTAGCTAGGCATGATGGCACATGCCTGTGGTCCCAGCTACTCGGGAGGCTGA
GGCAGGAGGATTGCAGGAGGTTTGCTTGAGCCGGGGAGGTCGAGTCTGCAGTGAACTGAGATTGCATCACTGCACTACAGCCTGGGTGAC
AGAGTAAGACCCTATCTCAAAAAAAAGAACTAATTGTAACAAACTATCTTTCAAATTATATCAAAACAGTGATTCATAAATTCCATGTTG
CCCAGAGATCATGAGGAGCTCTTCTATGATTTGACAGTGCAATTACTGAAGGGGAAGACACCATGCAAATACATGGTAAAAATATTCAAA
TTATTACTGATTTGACACAAAATATTGATGTAAATAACATAAAACTGTAATATGCCATTATGATGACATTAATGAAAAATTGGTTAATGA
ATGTCATTGAAAGAGCATGTACATCACTAAATGTTCTTAGTCACTGAAAGTGTGAAATAGCCTCTAAACTCATATGTGGAAAAAGAACTT
GAAAAAGGTTTCCAGAAATGTGACAATTCTAGTACTTTCATGACATTTTAAAAAAGGGATTGTAAAGACTGATGAAACCCTTAAAACCTC
TCAAGAATTAAAAATCATTTTTGATCAACAGAGTAAACTGATTTTTTATCTCTGTTGAAAGATATTTTTAAAATCATTGTCCTATGGAAA
AGTCATATAGAACGTTTGCTGTTTAATGTAGCACAGATGTATCAAAAAGCCATGCCAGGCAGTTATAGATATCTTAGTTTTCTGGATTTT
GTGACGTTTGTGGTATTTGTCAGATTTTTAAAATTTGTGATTTGTTGGGATTTGTTCCTCATTCACAGGTAATTTTATATACTTTTGTAT
TCACTTTCGAAAAGAAGGCAACTCTAAATTTTATGAACTTCAAGTGCTATAAAACAATTACCACAGTAAATTTTGAAAAATTCACCCCAA
AAAGAAACCTTGTATCCATTGGCAGTAACTCCCTATGCTCCGCCATTCCTCTCAGCTCCCTGTCTGGCAACCACTTCCTGTCTCTTCAGA
GTTGCCTCTTCTGGACATTACATATAAACGGAATTATACACTATGTGGCCTTTTATGACTGGCTTCTTTCACTTAGCATAATGTTTTCAA
GAGTCATCTGTGTTGTAGCATTTGTCAGTACTTCATTTATTTTTGTTTCCTAACAATACTCCATTGTAGGGATTGACCACACTTTATCCA
TTCATTGGTTGATGGACATTTGGGTTGTTTCCACTTTTTCTGCTGTTGTGAATAACAGTGCTAAGCACATTCATATGCAGTGTTTGTGTA
GATATATAATATGCTTTATTTTCTCTTGAGTACATAAAAGTGGAGCCTCTGAGTAATATAATAACTCTATGTTTGGTGTTTTGAAGAATT
GCTAAATTGTTTTCCAAAGCAGCTGCACCATTTTATATCCCTACCAGCAATGCATGAAGCTTCCAGTTTCTCCACATCATCACGAATACT
CCTTATTCTCTCTCTTTTTAGATATAGACATTCTGGCAGGTGTGACATTGTATCTCTTGTGGTTTAGATTTGCATTTGGAGCATGTCTTA
TGTGCACTTAAAAATATTAATATCTATTCTGCTGTTGTTGGGTAAACTGTTCTATAGATGTTGATATGGCTTCGCTGTGTCCCCACTCAA
AATCTCATCTTGACTTGTAATCCCCATAATCTCCATGTGTCAAGGGTGGGACCAGGTGGAGGTAATTGGATCATGAGGGTGGTTTTCCCT
ACTCTGTTTTCATGATAGTGAGTCTCACAAGGTCTGATGGTTTTATAAGCATCTGGCATTTCCCCTGCTTGCACTCAGGCTGTCCTGCCA
CACTGTGAAGAAGGTGCCTTGCTTCTCCTTTGCCTTCTGCCATGAGTGTAAGTTTCATGAGGCCTCCCCAGCCATGCTGAACTGTGAGTC
AATTAAACCTCTTTCCTTTATAAATTACCAAGCTGCGGCTATTTCTTCATAGCAGTGTGAGAACGGACTAATACAGGTGTTTTTTAGGTC
TTGTTATTGTGTCGTTCACGTCTTTTATTTCCTTGTTGATCTTACTCTTAGTTGTTCTATCCATCATTGAAAATGGGGCATTGGCCAGGC
GTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGACCAGCAGATCACTTGAGGTCAGGGGTTCGAGACCAGCGTGGCTAAC
ATGGAGAACTCCTGTCTCTACTAAAAATACAAAAATTAGTCAGGTGTGGCAGTGCGTGCCCGCCTATAGTCCCATCTACTTGGGAGGCTG
AGGCAGGGGAATTGCTTGAACCCTGGAGTCAGAGTTTGCAGTGAGCTGAGATCATGCCACTGCGCTCCAGTCTGGGTGACAGAGTGAGAC
TCAAAAAAGAAAAAAAAAAAAAAAAAAAAAAAGAAAGAAAATGAGACATTGGATTTGTAAGTTTCTGACAGGTTCATTTTGCCTGCTGCC
CAGATAGAGCCGATTTATGAGGACAGGGAAATTGCAATAGAGAAAGAGTTTAATACATGTAGAACTGGCTAAACAAGAGACTGGAGTTTT
ATTATTACTCAAATCAGCCTCCACAAAAATTTGGAGGCTAGGTCTTTTCAAAGATAGTTTGGTGGGCAGGGGTTTGTGTACTAAGAAACT
AAATGTTTCTTGTGTACTAAGTCAGCTTCTGGGTGGGGGCCAGAGGACCAGTTGAGCCAAGAATTCAAGAGGTACAGGTTCAAGTAGGGC
CATCTGGTTGTCAGAAATGCAAAAGCCTGGAAAGTCATCTCAAATGTTAGGTTCTACAATAGTCAAGTTATTTATAGTAATTGGGAAAGT
TGCAAATCTTGTGACCTCTGTAGAAAATAGGTGGTAATCTTTACACCTATATCTTAGTAGAATTCAGGCCCCTCACTTCCTCCTAACCTG
GTAGCCTTTCATTAGTTTTACAAAGGCAGTTTAATTTTGGGGGGCAGGGCTATTATCATCTAAACTATAAACTATAATCGTTTGTCCCAA
AGTTAGCTTGGCCCATGCCCAGGAATGACCAAGGGCAATTTGGAGATTAAAGTCAAGATGGAGTTGGTTAGATCAGATCTCTTTCACTGT
TATAATTTTCTCACTGTTAAAATTTACAAAGGCAGTTTCAAAATCTGAAACTTTTATTGTTAAATTATGTATTTATTCCTTTAGTTCTGT
CATGTTCTGCTTCTTATATTTTGGAACTCTGTTGTTAGGTGCATACATATTTATAATTGTTATATCTTCCTGATGGATTGGTATTGTAAT
CACTGTAAAATACACTATTATCATTGTAAAATATTCCTTTTTATCTCTAGTATTTTTTGTCTGTTTGACTTAAAGTCTATTTTGTTTGAT
ATTAGCATAGCTATTCTTGCTCTTACTGTGGCAATTTGTATGATACCTTTTTCTTTTAGCCTATTTATATCTTTGAATCAAAAGTTTGTC
TCCTGTAGATAGCATATAGTTGGATAATTTTTAGTTCTTTTGATTGGATTGTTTAATTCATTCATTTTTAGTGTTACTATTGATATGGCT
GGATTTGTGTCTGCAATTTTAATTTTTGTTTTCTATATGTCTCGTGTTTTTGTGGCTTTGCTTCTTCTTCTTTGCTTTCTTTTGCATTAA
GTATTTTCTAGTTTAACAACTTAATTTCTTAAATTATTTTTAACTATATTTTTACGTATTTCCTTAATGAATGCTTGATGGCTCACAATC
TCCTTCTCAGTTTATCAGAATCTACTTAAGTTTATACTAACTTATGTCCAGTGAGATAGAAACACATTTCTTCTTTATAGCTCTAGGTCC
TCTTCACTTGTTTTTGTGCTATTATTGTTATACTTACTACCTCTGTATATGTTACAAGCCCAAGAATACTATTCTACTTATTTATATAAT
TTTATGTTTTTTAAAGAACCTGAGACTGGAAGTGAGGGAAATAGGGCGTGCAGGAAGGAAGGAAGAGGAAGGAAAAGTGTGTGAAAGGGG
GCTCCACCTCCTTTAGTGGATACCCTGAGCTTATTTCCAGGGGCCTTTGTAAATTCCCAGTGACAACTCTTTGGAAGATGAAATCCCCCT
CTTCCCTGCATCTTATTAGAACAGTGTATCCTGGAGGACATCCCTTGCCTTTCACCAAGTGACCCTATACTGGCGGCAGAACTTCTCGAT
TTTGCGGATTTCAAAATGGCTCCACGTACTCATAGTTTTCATGACAGACTTCATTGCGATAGTCAAATACTGTTCCACTTACTGCAGTTG

>77989_77989_2_RPS6KA2-FGFR1OP_RPS6KA2_chr6_167271688_ENST00000503859_FGFR1OP_chr6_167424301_ENST00000366847_length(amino acids)=418AA_BP=165
MQVQRLLCQSRSTDSEAAAPSPPFLAPARAGSGSSSPEPWLGREGTAPEQPYCSPPGPSSGRRRPRAHDLLWEPDLSSPSPPPAGLCVPW
LPTSRLAVPLCRSEPLFISFPTINTRPAEKESLKMPIAQLLELWKKIEVEPMEIETTEEDLNLDVEPTTEDTAEEGALDLSDVHSPPKSP
EGKTSAQTTPSKIPRYKGQGKKKTSGQKAGDKKANDEANQSDTSVSLSEPKSKSSLHLLSHETKIGSFLSNRTLDGKDKAGLCPDEDDME
GDSFFDDPIPKPEKTYGLRKEPRKQAGSLASLSDAPPLKSGLSSLAGAPSLKDSESKRGNTVLKDLKLISDKIGSLGLGTGEDDDYVDDF

--------------------------------------------------------------
>77989_77989_3_RPS6KA2-FGFR1OP_RPS6KA2_chr6_167271688_ENST00000510118_FGFR1OP_chr6_167424301_ENST00000349556_length(transcript)=1505nt_BP=464nt
GCAGTACAGATTCCGAAGCCGCAGCGCCGTCCCCTCCTTTCCTCGCCCCAGCCCGAGCGGGAAGCGGCAGCAGCTCCCCAGAGCCCTGGC
TTGGCAGGGAGGGGACGGCGCCCGAGCAGCCATATTGCAGCCCCCCGGGTCCCTCCTCCGGCCGGCGCAGGCCCCGCGCTCACGACCTCC
TCTGGGAGCCGGATCTGTCCTCTCCATCGCCGCCACCCGCCGGCCTCTGCGTCCCTTGGCTTCCGACATCCCGTCTGGCCGTCCCCCTGT
GCCGGTCCGAGCCTCTGTTTATTTCCTTTCCTACTATCAATACTCGACCAGCAGAAAAGGAAAGTTTAAAAATGCCAATCGCACAGTTGC
TGGAACTATGGAAAAAGATCGAGGTGGAGCCTATGGAAATAGAGACCACAGAGGAGGATCTCAACCTGGATGTGGAGCCCACCACAGAAG
ACACTGCAGAAGAAGGTGCACTTGATCTATCTGATGTACATTCTCCACCAAAGTCACCAGAGGGAAAAACAAGTGCACAGACAACACCAA
GTAAGAAGGCCAATGATGAGGCCAATCAGAGTGATACAAGTGTCTCCTTGTCAGAACCCAAGAGCAAAAGCAGCCTTCACTTACTGTCCC
ATGAAACAAAAATTGGATCTTTTCTAAGCAACAGAACTTTAGATGGCAAAGACAAAGCTGGCCTTTGTCCAGATGAAGATGATATGGAAG
GAGATTCTTTCTTTGATGATCCCATTCCTAAGCCAGAGAAAACTTACGGTTTGAGGAAGGAACCTAGGAAGCAAGCAGGAAGTCTGGCCT
CGCTCTCGGATGCACCCCCCTTAAAAAGTGGACTCAGCTCCCTGGCGGGAGCCCCTTCTTTAAAAGACTCTGAGAGTAAAAGGGGAAATA
CAGTTTTGAAAGATCTGAAATTGATCAGTGATAAAATTGGATCACTTGGATTAGGAACTGGAGAAGATGATGACTATGTTGATGATTTTA
ATAGTACCAGCCATCGCTCAGAGAAAAGTGAGATAAGTATTGGTGAAGAGATAGAAGAAGACCTTTCTGTGGAAATAGATGACATCAATA
CCAGTGATAAGCTTGATGACCTCACACAAGATCTGACTGTATCCCAGCTCAGTGATGTTGCGGATTATCTGGAAGATGTTGCATAGACAC
GAAGAAGGAAGTATTCTAATTAACAAGGACAGAGGACTGACCGGTTCCATTTTTTTTTTTTCCAGACAATCACTCAGCTGGAATGTCTGC
TCTCTATTGGTGCCTTGCATTTCAAAAACACTGCAGATATTTTTTAAAAGTAATTTTCATTTTACTAAACAAAATACTTCCTATTTGAGC
CCATGTGTGGAAGATTTAATATTCTTAATTTAACTGTACATTTCTTTATGGAAATTGATTATCTACACTCAGTTTCATTACAGGGAAGGA

>77989_77989_3_RPS6KA2-FGFR1OP_RPS6KA2_chr6_167271688_ENST00000510118_FGFR1OP_chr6_167424301_ENST00000349556_length(amino acids)=323AA_BP=90
MSSPSPPPAGLCVPWLPTSRLAVPLCRSEPLFISFPTINTRPAEKESLKMPIAQLLELWKKIEVEPMEIETTEEDLNLDVEPTTEDTAEE
GALDLSDVHSPPKSPEGKTSAQTTPSKKANDEANQSDTSVSLSEPKSKSSLHLLSHETKIGSFLSNRTLDGKDKAGLCPDEDDMEGDSFF
DDPIPKPEKTYGLRKEPRKQAGSLASLSDAPPLKSGLSSLAGAPSLKDSESKRGNTVLKDLKLISDKIGSLGLGTGEDDDYVDDFNSTSH

--------------------------------------------------------------
>77989_77989_4_RPS6KA2-FGFR1OP_RPS6KA2_chr6_167271688_ENST00000510118_FGFR1OP_chr6_167424301_ENST00000366847_length(transcript)=13961nt_BP=464nt
GCAGTACAGATTCCGAAGCCGCAGCGCCGTCCCCTCCTTTCCTCGCCCCAGCCCGAGCGGGAAGCGGCAGCAGCTCCCCAGAGCCCTGGC
TTGGCAGGGAGGGGACGGCGCCCGAGCAGCCATATTGCAGCCCCCCGGGTCCCTCCTCCGGCCGGCGCAGGCCCCGCGCTCACGACCTCC
TCTGGGAGCCGGATCTGTCCTCTCCATCGCCGCCACCCGCCGGCCTCTGCGTCCCTTGGCTTCCGACATCCCGTCTGGCCGTCCCCCTGT
GCCGGTCCGAGCCTCTGTTTATTTCCTTTCCTACTATCAATACTCGACCAGCAGAAAAGGAAAGTTTAAAAATGCCAATCGCACAGTTGC
TGGAACTATGGAAAAAGATCGAGGTGGAGCCTATGGAAATAGAGACCACAGAGGAGGATCTCAACCTGGATGTGGAGCCCACCACAGAAG
ACACTGCAGAAGAAGGTGCACTTGATCTATCTGATGTACATTCTCCACCAAAGTCACCAGAGGGAAAAACAAGTGCACAGACAACACCAA
GTAAGATACCAAGGTATAAAGGACAAGGTAAGAAGAAGACAAGCGGGCAGAAGGCTGGTGACAAGAAGGCCAATGATGAGGCCAATCAGA
GTGATACAAGTGTCTCCTTGTCAGAACCCAAGAGCAAAAGCAGCCTTCACTTACTGTCCCATGAAACAAAAATTGGATCTTTTCTAAGCA
ACAGAACTTTAGATGGCAAAGACAAAGCTGGCCTTTGTCCAGATGAAGATGATATGGAAGGAGATTCTTTCTTTGATGATCCCATTCCTA
AGCCAGAGAAAACTTACGGTTTGAGGAAGGAACCTAGGAAGCAAGCAGGAAGTCTGGCCTCGCTCTCGGATGCACCCCCCTTAAAAAGTG
GACTCAGCTCCCTGGCGGGAGCCCCTTCTTTAAAAGACTCTGAGAGTAAAAGGGGAAATACAGTTTTGAAAGATCTGAAATTGATCAGTG
ATAAAATTGGATCACTTGGATTAGGAACTGGAGAAGATGATGACTATGTTGATGATTTTAATAGTACCAGCCATCGCTCAGAGAAAAGTG
AGATAAGTATTGGTGAAGAGATAGAAGAAGACCTTTCTGTGGAAATAGATGACATCAATACCAGTGATAAGCTTGATGACCTCACACAAG
ATCTGACTGTATCCCAGCTCAGTGATGTTGCGGATTATCTGGAAGATGTTGCATAGACACGAAGAAGGAAGTATTCTAATTAACAAGGAC
AGAGGACTGACCGGTTCCATTTTTTTTTTTTCCAGACAATCACTCAGCTGGAATGTCTGCTCTCTATTGGTGCCTTGCATTTCAAAAACA
CTGCAGATATTTTTTAAAAGTAATTTTCATTTTACTAAACAAAATACTTCCTATTTGAGCCCATGTGTGGAAGATTTAATATTCTTAATT
TAACTGTACATTTCTTTATGGAAATTGATTATCTACACTCAGTTTCATTACAGGGAAGGAACCCATGAAAACATCAGTGTTAAGAGCATG
ATGAAAGGTGTCAATAAAGCCGTAGGATCGCGCAACCCTTTGTGTGTGTGGCTGCTGGTACGTGTGATCTTTGAAAACCTTGGCTTTAGC
CCTCTGGAATCAGAGCTTACCCACCATAGTATATTTTGATATTAGGTGGTTCTACACATAGTTGGCAAAATGACTTGGTAAATTTGTAAT
GCTGAAGTATATTAGTATAAGTTAAATTTGATGTGTCAACTTTATTTTGTATTTCCTTCCATTTGGAAGGTTTGTTAGACCATTAAGGTT
ATATTAAAGTACTCTTGTGTGTGCTATTTAGTTTTGCTTGTTTTAAAGAAATCTAGAAGTGGTTATGAGTTTTAATTCATAGAATTGTCA
ATAACATAACATTTGCAATCGTCATTCCTCCTGTTATCCATGTAAGCAGCTTTAGTCGTAGGTTCTCTTCATTATAATTTATTATCTGTA
AAGATTCCTTGAAACTTAAATGCATCTGAAACCATTAAGCAGTGCTTTTATTTCAGATCTGTAAGTTAATTGTATTAAAATCCAAATTGG
AATGAAATAGTAGTAATGGCCTAAGACCATGTTCAGTTTGACAAGCTTTATATACTGTACATAATTTCATTGTAACCCTTAAAAATAGAG
CCAATAATAGAATTTCCACAGTCTCATTTATACGGTTAAAGCATTATTGCTATTATGTAGGTCACGGATGTTTATAATACTAAAGTATTT
TAAAATGTGCAAGTAGAAAAAACAGTAGAAAGTGATGCATGCATATTTATATATAAGTAAAGCAGGATTGTGCTGTTTTTGCACTTTATA
ATTTCAATTAAGTTGCGGCTTTTTACTACAAGTTAACTTTATTAGTAAAAGGAGCAAATTAGACCTAATTCATTGATCTCGGTTAAGTGA
GCAGACTGCATGACTTGTGTAATGCCAGTTTCTCATTTCATATTAGCCTAAATATTACAGAAATTACTCCTTGGGCTCTAAAATGTAGAG
GAAATGAAAATGTAAGGATTAAGGCTGTGTAACAGAATCTGGCTTTTTAAAATTTAAGTGAAACTAAGCTGTAAACATCAAGAGGAAGTA
GGACATAAACTGGGCCGGTACAGCCTGGGAGCCCTGTGTATTTCTGCCCTCCGTCTGTGAGCTGCTATCTCAGTCTCCTTCAGCTCTTCA
TGTCTTAGTAAACAGCACCACGTGCAGATGTAATCTTGTTGCAGTCCCCCAGTGTGGTTGTTATAAAATGCATTTCTTTGTAAGTCATCT
CTGTAAACAGTCACTTTCTAAAAGCACTATAGTTCTGGTCCCCTGGAATCTGGATCACATGTATGATTTATTTTTAATATTTGATAGGAA
CTAGGTTTCAGTGAAATGATTTGAAAGCATAGCAGGATGTGGCTTTTTAAATTTATGAAACTTTCGAACAGTAGCAACTGAAATTTGTCA
CTTTTCTGTTACGCAGAGAATCAGACCTTTTGATAATATTTGGGAGGGTAAAAGAAATATGCCAAATATGAAACTTTTTTGTCAGCACTA
CATACATCTTTTTTTTGCGGGGGGCGGGGGGGACAGAGTCTCACTGTGTCACTCAGACTGGAGTACAGTGATGCGATCTCGGCTCACTGC
AACCTCCGCCTCCTGGGTTCAAGCGATTCTCCTGCTTCAGCCTCCTGAGTAGCTGGGATTACAGGTGCACACCACCACGCCCGGCTAATT
TTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGTCAGGCTGGTCTTGAACTCCTGACCTCGTTCCTGCCTTAGCCTCCTAAAGTG
CCGGGATTACAGGCGTGAACCACCGCACCTGGCCAGTACTACATCCATTTTATTGAATGATTTTGAATGACTTAAAGTTCAACTATGAAA
AAGCTTTCTTTTCACATGTACTTTTTGATTAGGTATTATCAACTTATGAAACTTGAAGATGTGAAGTGACAGGTTTTGCATGTGATGAGT
GTTTTCTGTTAAAAAATAAATATTGAAATATTAACCCATTAAATACATTTTTATGGTAACCTATGTTTTACAGTGGAGTTTTAAAAATGC
TAGGTCTTTCTTTCATTTTATTGATAACTACAAATGAATAAAAAGCATTTATTCTCTTTGTTGATATTCGGTTGTGCTTTTATACTTTAT
GTTGGATAACAACCTGTGGGCAGTTGTGTAGATGCCATTAGTCCCTGCCTCATGCTTGCCCACAGCTCTTCCTCCCCTCCTTACTTCCCT
CTCCTGCCCATGCACCAGAGCTGTGCCAGCCCACTGCTGCACAGCCTCTGCACCTGAGCTTGCCAAAGCCCTTCCTGTCTCAAGGTGTGA
TATTTGCCCCTCCTTGTCTGGAATGTCCTTCCCCTAGAACTGCATGAAGCTGGTTTATTTCAGTCTCATGTTCAAAGACGCTTCCAGACC
TAAGGGAGATGTCCATTCTCCTCCCTGTCCCTGCCCCACCACTTGCATTTACCCCTTTTATTTTATTCATCTCAGCATACTCTGAAATGG
TCTTGCTTATTTTGTGTGTGTGTGTGTGTGTGTGTGTTTAACTATGAGCTCGTGAGAACAGGGATTTTCTTTTAAACTGCTGTGTACCTG
GCACAACATTTGTCCCCTAGTATGAGCTTGGCATCTTTGGGGCTGTAAACAGGCTTGAGCACTGACATGGGGCCTGGAGAATGTGGTTTC
TGGCTAGGCAGCTGGAACAATCTACAAAATCTGAGGGGAAAGCTGTCCTTACCCTAAACCTGGGGAGGTCCCTAGGTTCAAGTCTGCAGG
AAGGGGATCTGGTTCAGGAGAAGGCCGTCCTGTGAATTTGCCCCACCCACCAAGCTCAGCTGGAGCAGGGCCTCTGAAGGAGGTGCCCTC
TGTGTGGCTCTGCTGTGGTGTTGGTTCATGAAGGACATGGGAGGGGGGCAGGACAGGAGAGGCAGCTCTTCCTGGAGAAAAACACACCCA
GCCCAAGTTGGAGCCCTCCTGTGGCATTGGGTGGGGAGGATTCCCGCCATCAGTTCTCTGTCCATGGGTGCTAGTCTCACCCCTGCCCTC
CGAGCAGTCCGTGCTCCCAGTGTCCCTGTCCTCTTTTTTTTTTTTTTTTTTTTTTGAGGTGGAGTTTTGTTCTTGTTGCCCAGGCTGGAG
TGCCATGGGGCGACCTCGGCTCACTGCAACCCCTGCCTTCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGAGATTACA
GGTGCCTGCCACCATGCCCAGCTAATTTTTATAATTTTTTTGTAGAGACGGGATTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGA
CCTCAGGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGAATACAGGTGTGAGTCACGGTGCCCGGCCTAGTCTTCCTGCTCTAGGAA
GGGACGTGTTTGGGGAGGAAATCCAGGGCAGCTACCTTTGTGAGTTGTCCTAATGCTGCGTTCAGAGTTCCACACGTTCAACAAGCATCT
GACATTTAAGGAAAGTGAATGTATGTCATGAAAGACAGATGAACAAAGAACTGATCTTGAAGAAAATGTAATCAGGAAACGAGATAATTC
AAGAACAAAAACCTGTGAAGGACTGAATGTGTCCCCCAAAATGTGTATGTCGAAACCTAATCCCACATAGGATGGAATTAGGTAGGGCCT
CTGGAAGTTGATGAGATCATTAGCGCCCTTATAGGAGGCCCGGGAGAGCTGCTTTGCCCCTTCCAGCGTGTGAGGACACAGTGAGGAGGT
GTTGCCTATGAGGAAACAGGCCCTCCCAGATGGTGAACCTGCCGGTACCTTGATCTTGGACTTAAGCCATCTGAGCTGTGAGCCCTACAC
TTCCATTCTTTATAAATTATCCAGTCCAAGGTACTTTAGGAACCTGAATGGATTAAGACAAACCTGATTATGCCACTCCGAGATTTGAGG
TAACATTTGAATCTAAAAGAGGCTATATGAAAGAGGTTATAATAAAAATGATTTTTGACTAAAAAATTGTTGGCCTAAGATAATTCAGTA
GCAGGGCTGAATAATGGGATGACTCAAAATCAGTAAGCTCAAAGGCAATTTCAAAGAAATCTTTATGTTTAGCAAGAAGACCAAGATGAC
AAGATGCGCCAGGAGACTTGGCCAGAGGACCTCCAGGCTGACAAAGTTTCCCCGAGGAAGTCAGATTGGAAAAGTGTCCTCAGGTTCAAG
GAAACCTGGGTGTGCACCGGGTGAATGAGAGTGGCAGACAGAAGGAAACAGCAAGGCCTCTGAGGTAGGAGGGACAGCGTTTTTGAATGT
GAAATTTATTCCCTGATACATGTTTTTAAAAATGAATCTTGCTGCCCTTAGAAAATGAACCCCCGAACAAGGTAAGGTCGAGCTGGCCCC
TCGTGTCATCCGACTTTGCGTTGTGGCCCTGCCTGCAGAAACGTGTGCTCTGCTACAGCCCTGGGAGGAGGGGCCGGGCTCCCAACTCCT
GCCCCGCTTCTAGCACATGCTGTGCTTGGCCACTTCTCTGCCTCTTAGTTTAACAGCAGCACTGGGCAAGGTTTGCCCTCTGCACACCAG
ACCGGCTTCCCAAGAACCGGGGAAGAGGAGAGGGCATGCCTGGGGCCTGAGCTTAGTGGGCCGGGTGGAGGCAGGAGGTACTGCATGGAG
GAGCGTGGACAGTGGCATGCAGGAGGCCAGTCATTCTGCGGTTTTAGCTGGAGGTTTGTTTTTGGTAGTTTGTAGAATCATCAGATTTGA
TGATGAAACTTTTTTTCCATAAATGTTAAATTTTCAGACACTTGTATTTTTTTTTTCCTTTTTTTTTTTTGAGACTGAGTCACTGTCGCC
CAGGCTGGAGTGCAGTGGTACTAGCTCGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGC
TGGGATTACAGATGTGTTTCACCATGCCCGGCGAATTTTTTTTGTATTTTTAGTAGACACGGGATCTCACCGTGTTGGCCAGGCTGGTCT
TGAACTCCTGACCTATGGTGATCCGCACCCCTCCCCGCCCCCCCCGCGGCCCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACT
GTACCCAGCCCTGTATTTTCTTTAAAAACCAATTTTGGGCCGGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGC
AGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACATGGTGAAAACCCATCTCTACTAAAAATACAGAAAAAAAATGAGCTG
GGTGCGATGGTGGGTGCCTGCAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCAGGAGGCGGAGCTTGCAGTGAGC
CCAGATCACGCCCCTGCACTCCAGCCTGGGTGACAGAGCGAGACTCCGTCTCAAAAACAACAACAACAACGAAAAAACGATTTTGGCATG
TTTTGTAAGTTGCCAGACTATTGGATATACCTCTTAATCATACTTTGTTTGAAATCCTTTGTGGTTTCTAAAGCACTAGTAGCTTTCTGA
AAGGAAAATTTTTAATGAATGAAGCATGCTTCATCCTGCACATCCCCTCCTGCCCCAGCACCCCTACTGCCCATGCGCCTCTCCTGCCCC
AGCACCCCTACTGCCCCAGTGCCAGGCCTTTTCTAGCAGCTCTCATGGGTTCATCCCTGCTGCGGGCATTGCTCCACCAAGGGGCAGTGC
TCTCCCTGCCGGTAAGTGTTGGAACTTCACGTTTCCCTCTAGTTTTCTCTTTACATTTTAACATACACTATTATGTGTCAATATATTAAT
TATATATTAATTACATTTATAGAGGTTAGGTATATATGGCAGATCATATCTGAGCGTGAATTACATTCTCCAATATTTTTATTTGTCATG
ATTTATTGCAGGGTTCACTTATTTGATCTACCCCAACTTAACACACATTTCCAAGAAAATATCCATCACACTAGAAAGAAAGAAAGAGGA
AGGAAGGAAGGGAGGGAGGGAGAGAAGGAGAAAGGAAGAAAGGGAAGGAAAATGGAATGGAGGAAGGGAAAAATGGAAGGAGGAAGGAAG
GAAGGGAAAGAATGAAGAAAGCCATTTGTTCCTGCAAACCTAAACCTCTTTGTAGTAAGTTCTGGCAGAAGGTGTGTTTCTGGAGTTAAA
CTACAGGCTTGGAAATGGAATTTCTTAGCCTAATTTCTAAATTAGAACTGCTTATGCAAATTAACACTCCGTACATTTCAACAAGCAGTT
GGCTGATTTCTTCTGTCCACTCCACCTGCAGATGCAGAGGTGGCCCCATCCTGTGATGTGCCACCACATCCCTTTTCAGTGAAGGGCTTT
GTTGGCTGCTGTGGGCATTCTCATGGCCTCTCCAGGGATGGCCTCCACTGTAGAGACCTATGTCACCAAGGCCAGGCCCTCTCAGGGGGC
TCCATCCAACGACCATTCTGCCTCAGGGTAAGAGGCCCGGCCCTCTCAGCCTGAGTCCATTCTGGCTCCAGAGCTCCCTGAGAGCTTGCC
TGGCAAGTTACTCTTGCAATTCTAGCTTCCAGCAGGCGTTGATTTCTGGGGCACTTTTGATAAACTCCTGGCAGGAAACTCAATCTCTGG
GGGTCAGAGTCCACTTCCTGGGGAGCCCAATCTGTGACCCCTAGGAGTGGGGACCATGGAAGCACTTGGCTCTCCAGCATGTGCTGAATA
GGGGGCGCTGCCTGCAATGTCCACGTGGAAACCTGGCTGGGAGAATGCCTGTGTGCTCTGCATGGGGATGTAAAGGTGTGAGCAAACCTT
CTTCAGAGAGGGGATGTTCAATGCGAAATTTGAACATTGGGACCTGAAAAACTGATGGGCTGATGGGGTCTGCCCATGATTGGCAGCCTT
CATAGAATCACGAGGGAGGAGCACAGGCCACCCTAGACAGGAGGGGTCCCCTACTGACAGGGAGGTGCTGTCGGGGCAGCAGGCACGTGC
AGGAAAACGGAAAAGCAGAGTAATTGAATGTAAATCATGCAACTCCACTACAGTGGCTAGAAGCCTGGATGGGCAACTTGGCTGAGTGAT
GTTGGGCAAGTTATTTAATATCAGTATTCTCAGTTTTCTCATCTGTAAAGGGGATTAAATACTTCCTTCCCTTACAGGGCTGCCCTGGTC
TTAAGTAATGCCCACAGAGAGCTTAGCATTGTTCTTGGCAAGTCACTAGTACTCAGTAAATACTATTTTTATTAAGAAGGTAAGATTCAC
AGGACTTAGTGTCTTAACTAGATGTTGAGAGTAAGGAGAAGAGAGAATACTTCTCGGATGATTGTTCAGTTTCTGATGAATGTCTGTTCC
CCTTTCAAAACCTAATTCAGATGTCACTTCCTCCTCAAAGCTCTCGCCCCGCGCCGAGCTACTGTGATGTATTTTTATGACCTGGCAGCT
TTTTTCTCATATCCCTGTTAGCGGTATGTGGTAAGAACATGAGACACAGAATCAGAAACCATGGATTTCTGGTCTTGACTCCACTACCAC
TCAGAGGAACCTCACGGTGGATGCCGTAAGTGTTTACACTGAAAAGGATTTTCACGAAAACCTGCATTTTCATTTCGTTCACAAGAGAAT
TATGAGACTAGAAAAACAACAATTCTTAGTATACCACAGACTGTGGTGCCTAGGAATAACAGACAAGCTTTAACTCACACGATGAGCATC
TTTATTTAGCTCTGCTTTTAGATATCTGCATGATAAAGATGAGTGATCCAACGTTAGAAATCATCTGGACATTAAAACTGAATTGTAGGC
AGGCGTGGTGGCTCACACCTGTAATCCCAGCACTTACGGAGACCAAGGCGGGCAGATTGCTTGAGCTCAGGAGTTTGTGAGACTAGCCTG
GGCAACATAGTAAGACCCCTATCTCTACAAAAAATATAAAAATTAGCTAGGCATCATGGCCTGTGCCTGTAGTCCTAGCTATTGAGGAAA
CTGATGCAGGAGGATCATTTGAGCTCAGGAGTTTGAGACCATTCTGGGCAATACGGTGAAACCCTGTCTCTACAAAAAAATGCAAAGATT
AGCTAGGCATGATGGCACATGCCTGTGGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGGATTGCAGGAGGTTTGCTTGAGCCGGGGAGGT
CGAGTCTGCAGTGAACTGAGATTGCATCACTGCACTACAGCCTGGGTGACAGAGTAAGACCCTATCTCAAAAAAAAGAACTAATTGTAAC
AAACTATCTTTCAAATTATATCAAAACAGTGATTCATAAATTCCATGTTGCCCAGAGATCATGAGGAGCTCTTCTATGATTTGACAGTGC
AATTACTGAAGGGGAAGACACCATGCAAATACATGGTAAAAATATTCAAATTATTACTGATTTGACACAAAATATTGATGTAAATAACAT
AAAACTGTAATATGCCATTATGATGACATTAATGAAAAATTGGTTAATGAATGTCATTGAAAGAGCATGTACATCACTAAATGTTCTTAG
TCACTGAAAGTGTGAAATAGCCTCTAAACTCATATGTGGAAAAAGAACTTGAAAAAGGTTTCCAGAAATGTGACAATTCTAGTACTTTCA
TGACATTTTAAAAAAGGGATTGTAAAGACTGATGAAACCCTTAAAACCTCTCAAGAATTAAAAATCATTTTTGATCAACAGAGTAAACTG
ATTTTTTATCTCTGTTGAAAGATATTTTTAAAATCATTGTCCTATGGAAAAGTCATATAGAACGTTTGCTGTTTAATGTAGCACAGATGT
ATCAAAAAGCCATGCCAGGCAGTTATAGATATCTTAGTTTTCTGGATTTTGTGACGTTTGTGGTATTTGTCAGATTTTTAAAATTTGTGA
TTTGTTGGGATTTGTTCCTCATTCACAGGTAATTTTATATACTTTTGTATTCACTTTCGAAAAGAAGGCAACTCTAAATTTTATGAACTT
CAAGTGCTATAAAACAATTACCACAGTAAATTTTGAAAAATTCACCCCAAAAAGAAACCTTGTATCCATTGGCAGTAACTCCCTATGCTC
CGCCATTCCTCTCAGCTCCCTGTCTGGCAACCACTTCCTGTCTCTTCAGAGTTGCCTCTTCTGGACATTACATATAAACGGAATTATACA
CTATGTGGCCTTTTATGACTGGCTTCTTTCACTTAGCATAATGTTTTCAAGAGTCATCTGTGTTGTAGCATTTGTCAGTACTTCATTTAT
TTTTGTTTCCTAACAATACTCCATTGTAGGGATTGACCACACTTTATCCATTCATTGGTTGATGGACATTTGGGTTGTTTCCACTTTTTC
TGCTGTTGTGAATAACAGTGCTAAGCACATTCATATGCAGTGTTTGTGTAGATATATAATATGCTTTATTTTCTCTTGAGTACATAAAAG
TGGAGCCTCTGAGTAATATAATAACTCTATGTTTGGTGTTTTGAAGAATTGCTAAATTGTTTTCCAAAGCAGCTGCACCATTTTATATCC
CTACCAGCAATGCATGAAGCTTCCAGTTTCTCCACATCATCACGAATACTCCTTATTCTCTCTCTTTTTAGATATAGACATTCTGGCAGG
TGTGACATTGTATCTCTTGTGGTTTAGATTTGCATTTGGAGCATGTCTTATGTGCACTTAAAAATATTAATATCTATTCTGCTGTTGTTG
GGTAAACTGTTCTATAGATGTTGATATGGCTTCGCTGTGTCCCCACTCAAAATCTCATCTTGACTTGTAATCCCCATAATCTCCATGTGT
CAAGGGTGGGACCAGGTGGAGGTAATTGGATCATGAGGGTGGTTTTCCCTACTCTGTTTTCATGATAGTGAGTCTCACAAGGTCTGATGG
TTTTATAAGCATCTGGCATTTCCCCTGCTTGCACTCAGGCTGTCCTGCCACACTGTGAAGAAGGTGCCTTGCTTCTCCTTTGCCTTCTGC
CATGAGTGTAAGTTTCATGAGGCCTCCCCAGCCATGCTGAACTGTGAGTCAATTAAACCTCTTTCCTTTATAAATTACCAAGCTGCGGCT
ATTTCTTCATAGCAGTGTGAGAACGGACTAATACAGGTGTTTTTTAGGTCTTGTTATTGTGTCGTTCACGTCTTTTATTTCCTTGTTGAT
CTTACTCTTAGTTGTTCTATCCATCATTGAAAATGGGGCATTGGCCAGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCC
AAGACCAGCAGATCACTTGAGGTCAGGGGTTCGAGACCAGCGTGGCTAACATGGAGAACTCCTGTCTCTACTAAAAATACAAAAATTAGT
CAGGTGTGGCAGTGCGTGCCCGCCTATAGTCCCATCTACTTGGGAGGCTGAGGCAGGGGAATTGCTTGAACCCTGGAGTCAGAGTTTGCA
GTGAGCTGAGATCATGCCACTGCGCTCCAGTCTGGGTGACAGAGTGAGACTCAAAAAAGAAAAAAAAAAAAAAAAAAAAAAAGAAAGAAA
ATGAGACATTGGATTTGTAAGTTTCTGACAGGTTCATTTTGCCTGCTGCCCAGATAGAGCCGATTTATGAGGACAGGGAAATTGCAATAG
AGAAAGAGTTTAATACATGTAGAACTGGCTAAACAAGAGACTGGAGTTTTATTATTACTCAAATCAGCCTCCACAAAAATTTGGAGGCTA
GGTCTTTTCAAAGATAGTTTGGTGGGCAGGGGTTTGTGTACTAAGAAACTAAATGTTTCTTGTGTACTAAGTCAGCTTCTGGGTGGGGGC
CAGAGGACCAGTTGAGCCAAGAATTCAAGAGGTACAGGTTCAAGTAGGGCCATCTGGTTGTCAGAAATGCAAAAGCCTGGAAAGTCATCT
CAAATGTTAGGTTCTACAATAGTCAAGTTATTTATAGTAATTGGGAAAGTTGCAAATCTTGTGACCTCTGTAGAAAATAGGTGGTAATCT
TTACACCTATATCTTAGTAGAATTCAGGCCCCTCACTTCCTCCTAACCTGGTAGCCTTTCATTAGTTTTACAAAGGCAGTTTAATTTTGG
GGGGCAGGGCTATTATCATCTAAACTATAAACTATAATCGTTTGTCCCAAAGTTAGCTTGGCCCATGCCCAGGAATGACCAAGGGCAATT
TGGAGATTAAAGTCAAGATGGAGTTGGTTAGATCAGATCTCTTTCACTGTTATAATTTTCTCACTGTTAAAATTTACAAAGGCAGTTTCA
AAATCTGAAACTTTTATTGTTAAATTATGTATTTATTCCTTTAGTTCTGTCATGTTCTGCTTCTTATATTTTGGAACTCTGTTGTTAGGT
GCATACATATTTATAATTGTTATATCTTCCTGATGGATTGGTATTGTAATCACTGTAAAATACACTATTATCATTGTAAAATATTCCTTT
TTATCTCTAGTATTTTTTGTCTGTTTGACTTAAAGTCTATTTTGTTTGATATTAGCATAGCTATTCTTGCTCTTACTGTGGCAATTTGTA
TGATACCTTTTTCTTTTAGCCTATTTATATCTTTGAATCAAAAGTTTGTCTCCTGTAGATAGCATATAGTTGGATAATTTTTAGTTCTTT
TGATTGGATTGTTTAATTCATTCATTTTTAGTGTTACTATTGATATGGCTGGATTTGTGTCTGCAATTTTAATTTTTGTTTTCTATATGT
CTCGTGTTTTTGTGGCTTTGCTTCTTCTTCTTTGCTTTCTTTTGCATTAAGTATTTTCTAGTTTAACAACTTAATTTCTTAAATTATTTT
TAACTATATTTTTACGTATTTCCTTAATGAATGCTTGATGGCTCACAATCTCCTTCTCAGTTTATCAGAATCTACTTAAGTTTATACTAA
CTTATGTCCAGTGAGATAGAAACACATTTCTTCTTTATAGCTCTAGGTCCTCTTCACTTGTTTTTGTGCTATTATTGTTATACTTACTAC
CTCTGTATATGTTACAAGCCCAAGAATACTATTCTACTTATTTATATAATTTTATGTTTTTTAAAGAACCTGAGACTGGAAGTGAGGGAA
ATAGGGCGTGCAGGAAGGAAGGAAGAGGAAGGAAAAGTGTGTGAAAGGGGGCTCCACCTCCTTTAGTGGATACCCTGAGCTTATTTCCAG
GGGCCTTTGTAAATTCCCAGTGACAACTCTTTGGAAGATGAAATCCCCCTCTTCCCTGCATCTTATTAGAACAGTGTATCCTGGAGGACA
TCCCTTGCCTTTCACCAAGTGACCCTATACTGGCGGCAGAACTTCTCGATTTTGCGGATTTCAAAATGGCTCCACGTACTCATAGTTTTC
ATGACAGACTTCATTGCGATAGTCAAATACTGTTCCACTTACTGCAGTTGCCTACAGTCTGGGTTTTGTTCAGTTGAAATTAAATAAATT

>77989_77989_4_RPS6KA2-FGFR1OP_RPS6KA2_chr6_167271688_ENST00000510118_FGFR1OP_chr6_167424301_ENST00000366847_length(amino acids)=343AA_BP=90
MSSPSPPPAGLCVPWLPTSRLAVPLCRSEPLFISFPTINTRPAEKESLKMPIAQLLELWKKIEVEPMEIETTEEDLNLDVEPTTEDTAEE
GALDLSDVHSPPKSPEGKTSAQTTPSKIPRYKGQGKKKTSGQKAGDKKANDEANQSDTSVSLSEPKSKSSLHLLSHETKIGSFLSNRTLD
GKDKAGLCPDEDDMEGDSFFDDPIPKPEKTYGLRKEPRKQAGSLASLSDAPPLKSGLSSLAGAPSLKDSESKRGNTVLKDLKLISDKIGS

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Fusion Gene PPI Analysis for RPS6KA2-FGFR1OP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RPS6KA2-FGFR1OP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RPS6KA2-FGFR1OP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource