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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RPS6KA2-KIFC1 (FusionGDB2 ID:77990)

Fusion Gene Summary for RPS6KA2-KIFC1

check button Fusion gene summary
Fusion gene informationFusion gene name: RPS6KA2-KIFC1
Fusion gene ID: 77990
HgeneTgene
Gene symbol

RPS6KA2

KIFC1

Gene ID

6196

3833

Gene nameribosomal protein S6 kinase A2kinesin family member C1
SynonymsHU-2|MAPKAPK1C|RSK|RSK3|S6K-alpha|S6K-alpha2|p90-RSK3|p90RSK2|pp90RSK3HSET|KNSL2
Cytomap

6q27

6p21.32

Type of geneprotein-codingprotein-coding
Descriptionribosomal protein S6 kinase alpha-2MAP kinase-activated protein kinase 1cMAPK-activated protein kinase 1cMAPKAP kinase 1Cmitogen-activated protein kinase-activated protein kinase 1Cribosomal S6 kinase 3ribosomal protein S6 kinase, 90kDa, polypeptidekinesin-like protein KIFC1kinesin-like 2kinesin-like protein 2kinesin-related protein HSET
Modification date2020031320200313
UniProtAcc.

Q9BW19

Ensembl transtripts involved in fusion geneENST00000265678, ENST00000366863, 
ENST00000405189, ENST00000481261, 
ENST00000503859, ENST00000509742, 
ENST00000510118, 		ENST00000374523, 
ENST00000417146, ENST00000448818, 
ENST00000467671, ENST00000486695, 
ENST00000492999, ENST00000428849, 
Fusion gene scores* DoF score9 X 9 X 5=4053 X 3 X 2=18
# samples 103
** MAII scorelog2(10/405*10)=-2.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RPS6KA2 [Title/Abstract] AND KIFC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRPS6KA2(167040409)-KIFC1(33365806), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPS6KA2

GO:0008285

negative regulation of cell proliferation

16878154

HgeneRPS6KA2

GO:0043065

positive regulation of apoptotic process

16878154

HgeneRPS6KA2

GO:0045786

negative regulation of cell cycle

16878154


check buttonFusion gene breakpoints across RPS6KA2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KIFC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-IE-A3OV-01ARPS6KA2chr6

167040409

-KIFC1chr6

33365806

+


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Fusion Gene ORF analysis for RPS6KA2-KIFC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000265678ENST00000374523RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
5CDS-intronENST00000265678ENST00000417146RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
5CDS-intronENST00000265678ENST00000448818RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
5CDS-intronENST00000265678ENST00000467671RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
5CDS-intronENST00000265678ENST00000486695RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
5CDS-intronENST00000265678ENST00000492999RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
5UTR-3CDSENST00000366863ENST00000428849RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
5UTR-intronENST00000366863ENST00000374523RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
5UTR-intronENST00000366863ENST00000417146RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
5UTR-intronENST00000366863ENST00000448818RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
5UTR-intronENST00000366863ENST00000467671RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
5UTR-intronENST00000366863ENST00000486695RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
5UTR-intronENST00000366863ENST00000492999RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
In-frameENST00000265678ENST00000428849RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-3CDSENST00000405189ENST00000428849RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-3CDSENST00000481261ENST00000428849RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-3CDSENST00000503859ENST00000428849RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-3CDSENST00000509742ENST00000428849RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-3CDSENST00000510118ENST00000428849RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000405189ENST00000374523RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000405189ENST00000417146RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000405189ENST00000448818RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000405189ENST00000467671RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000405189ENST00000486695RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000405189ENST00000492999RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000481261ENST00000374523RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000481261ENST00000417146RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000481261ENST00000448818RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000481261ENST00000467671RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000481261ENST00000486695RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000481261ENST00000492999RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000503859ENST00000374523RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000503859ENST00000417146RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000503859ENST00000448818RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000503859ENST00000467671RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000503859ENST00000486695RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000503859ENST00000492999RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000509742ENST00000374523RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000509742ENST00000417146RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000509742ENST00000448818RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000509742ENST00000467671RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000509742ENST00000486695RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000509742ENST00000492999RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000510118ENST00000374523RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000510118ENST00000417146RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000510118ENST00000448818RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000510118ENST00000467671RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000510118ENST00000486695RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000510118ENST00000492999RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265678RPS6KA2chr6167040409-ENST00000428849KIFC1chr633365806+25673231942332712

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265678ENST00000428849RPS6KA2chr6167040409-KIFC1chr633365806+0.0129628670.98703706

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Fusion Genomic Features for RPS6KA2-KIFC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RPS6KA2chr6167040408-KIFC1chr633365805+1.62E-070.9999999
RPS6KA2chr6167040408-KIFC1chr633365805+1.62E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RPS6KA2-KIFC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:167040409/chr6:33365806)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KIFC1

Q9BW19

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity). {ECO:0000250|UniProtKB:Q9QWT9, ECO:0000269|PubMed:15843429}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKIFC1chr6:167040409chr6:33365806ENST00000374523011142_3060674.0Coiled coilOntology_term=ECO:0000255
TgeneKIFC1chr6:167040409chr6:33365806ENST00000428849011142_3064674.0Coiled coilOntology_term=ECO:0000255
TgeneKIFC1chr6:167040409chr6:33365806ENST00000448818011142_3060674.0Coiled coilOntology_term=ECO:0000255
TgeneKIFC1chr6:167040409chr6:33365806ENST00000374523011310_6630674.0DomainKinesin motor
TgeneKIFC1chr6:167040409chr6:33365806ENST00000428849011310_6634674.0DomainKinesin motor
TgeneKIFC1chr6:167040409chr6:33365806ENST00000448818011310_6630674.0DomainKinesin motor
TgeneKIFC1chr6:167040409chr6:33365806ENST00000374523011410_4170674.0Nucleotide bindingATP
TgeneKIFC1chr6:167040409chr6:33365806ENST00000428849011410_4174674.0Nucleotide bindingATP
TgeneKIFC1chr6:167040409chr6:33365806ENST00000448818011410_4170674.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRPS6KA2chr6:167040409chr6:33365806ENST00000265678-121319_38833734.0DomainAGC-kinase C-terminal
HgeneRPS6KA2chr6:167040409chr6:33365806ENST00000265678-121415_67233734.0DomainProtein kinase 2
HgeneRPS6KA2chr6:167040409chr6:33365806ENST00000265678-12159_31833734.0DomainProtein kinase 1
HgeneRPS6KA2chr6:167040409chr6:33365806ENST00000503859-122319_3880742.0DomainAGC-kinase C-terminal
HgeneRPS6KA2chr6:167040409chr6:33365806ENST00000503859-122415_6720742.0DomainProtein kinase 2
HgeneRPS6KA2chr6:167040409chr6:33365806ENST00000503859-12259_3180742.0DomainProtein kinase 1
HgeneRPS6KA2chr6:167040409chr6:33365806ENST00000265678-121421_42933734.0Nucleotide bindingATP
HgeneRPS6KA2chr6:167040409chr6:33365806ENST00000265678-12165_7333734.0Nucleotide bindingATP
HgeneRPS6KA2chr6:167040409chr6:33365806ENST00000503859-122421_4290742.0Nucleotide bindingATP
HgeneRPS6KA2chr6:167040409chr6:33365806ENST00000503859-12265_730742.0Nucleotide bindingATP


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Fusion Gene Sequence for RPS6KA2-KIFC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>77990_77990_1_RPS6KA2-KIFC1_RPS6KA2_chr6_167040409_ENST00000265678_KIFC1_chr6_33365806_ENST00000428849_length(transcript)=2567nt_BP=323nt
GGGAGGCGGAGAAGGAGGCGGAGGGAGCGATTGTGGCCCCGGCCGCGGTGGCCGGCGCGGCCTGCCCTTTGTGACCGCAGCTCGCGCCCC
ACGCCCCGCGCCCATGGCCGCCGTGCCGGGCTCCCTGGCCACGCGTGCCCGCCCGCGGACCTGAGCCCCGCGCCTGGGATGCCGGGGATG
CGCGTCCCCCGGCCCTGCGGCTGCTCCGGGCTGGGCGCGGGGCGATGGACCTGAGCATGAAGAAGTTCGCCGTGCGCAGGTTCTTCTCTG
TGTACCTGCGCAGGAAGTCGCGCTCCAAGAGCTCCAGCCTGAGCCGGCTCGAGAGGTCCCCCCTATTGGAAGTAAAGGGGAACATAGAAC
TGAAGAGACCTCTGATTAAGGCCCCTTCCCAGCTGCCTCTCTCAGGAAGCAGACTCAAGAGGAGGCCTGACCAGATGGAAGATGGCCTGG
AGCCTGAGAAGAAACGGACAAGAGGCCTGGGTGCAACGACCAAAATTACCACATCCCACCCAAGAGTTCCATCCCTCACTACAGTGCCAC
AGACACAAGGCCAGACCACAGCTCAAAAAGTTTCCAAGAAGACAGGACCCCGGTGTTCCACAGCTATTGCCACAGGGTTGAAGAACCAGA
AGCCAGTTCCTGCTGTTCCTGTCCAGAAGTCTGGCACATCAGGTGTTCCTCCCATGGCAGGAGGGAAGAAACCCAGCAAACGTCCAGCCT
GGGACTTAAAGGGTCAGTTATGTGACCTAAATGCAGAACTAAAACGGTGCCGTGAGAGGACTCAAACGTTGGACCAAGAGAACCAGCAGC
TTCAGGACCAGCTCAGAGATGCCCAGCAGCAGGTCAAGGCCCTGGGGACAGAGCGCACAACACTGGAGGGGCATTTAGCCAAGGTACAGG
CCCAGGCTGAGCAGGGCCAACAGGAGCTGAAGAACTTGCGTGCTTGTGTCCTGGAGCTGGAAGAGCGGCTGAGCACGCAGGAGGGCTTGG
TGCAAGAGCTTCAGAAAAAACAGGTGGAATTGCAGGAAGAACGGAGGGGACTGATGTCCCAACTAGAGGAGAAGGAGAGGAGGCTGCAGA
CATCAGAAGCAGCCCTGTCAAGCAGCCAAGCAGAGGTGGCATCTCTGCGGCAGGAGACTGTGGCCCAGGCAGCCTTACTGACTGAGCGGG
AAGAACGTCTTCATGGGCTAGAAATGGAGCGCCGGCGACTGCACAACCAGCTGCAGGAACTCAAGGGCAACATCCGTGTATTCTGCCGGG
TCCGCCCTGTCCTGCCGGGGGAGCCCACTCCACCCCCTGGCCTCCTCCTGTTTCCCTCTGGCCCTGGTGGGCCCTCTGATCCTCCAACCC
GCCTTAGCCTCTCCCGGTCTGACGAGCGGCGTGGGACCCTGAGTGGGGCACCAGCTCCCCCAACTCGCCATGATTTTTCCTTTGACCGGG
TATTCCCACCAGGAAGTGGACAGGATGAAGTGTTTGAAGAGATTGCCATGCTTGTCCAGTCAGCCCTGGATGGCTATCCAGTATGCATCT
TTGCCTATGGCCAGACAGGCAGTGGCAAGACCTTCACAATGGAGGGTGGGCCTGGGGGAGACCCCCAGTTGGAGGGGCTGATCCCTCGGG
CCCTGCGGCACCTCTTCTCTGTGGCTCAGGAGCTGAGTGGTCAGGGCTGGACCTACAGCTTTGTAGCAAGCTACGTAGAGATCTACAATG
AGACTGTCCGGGACCTGCTGGCCACTGGAACCCGGAAGGGTCAAGGGGGCGAGTGTGAGATTCGCCGTGCAGGGCCAGGGAGTGAGGAGC
TCACTGTCACCAATGCTCGATATGTCCCTGTCTCCTGTGAGAAAGAAGTGGACGCCCTGCTTCATCTGGCCCGCCAGAATCGGGCTGTGG
CCCGCACAGCCCAGAATGAACGGTCATCACGCAGCCACAGTGTATTCCAGCTACAGATTTCTGGGGAGCACTCCAGCCGAGGCCTGCAGT
GTGGGGCCCCCCTCAGTCTTGTGGACCTGGCCGGGAGTGAGCGACTTGACCCCGGCTTAGCCCTCGGCCCCGGGGAGCGGGAACGCCTTC
GGGAAACACAGGCCATTAACAGCAGCCTGTCCACGCTGGGGCTGGTTATCATGGCCCTGAGCAACAAGGAGTCCCACGTGCCTTACCGGA
ACAGCAAACTGACCTACCTGCTGCAGAACTCTCTGGGTGGTAGTGCTAAGATGCTCATGTTTGTGAACATTTCTCCACTGGAAGAGAACG
TCTCCGAGTCCCTCAACTCTCTACGCTTTGCCTCCAAGGTGAACCAGTGTGTTATTGGTACTGCTCAGGCCAACAGGAAGTGAAGACGGA
TCCAGATCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCCCTATGTCTATGTATCGGGTGAGGGGTGGGAG
GGTTGCTGGAGGGTGCTTTATTGGGTGGAGGGCACCATGTCCCAGGGCTATCAAATAAAGAATAGTTTGGTTTTTTTTTTAAATAAAGGT

>77990_77990_1_RPS6KA2-KIFC1_RPS6KA2_chr6_167040409_ENST00000265678_KIFC1_chr6_33365806_ENST00000428849_length(amino acids)=712AA_BP=38
MRLLRAGRGAMDLSMKKFAVRRFFSVYLRRKSRSKSSSLSRLERSPLLEVKGNIELKRPLIKAPSQLPLSGSRLKRRPDQMEDGLEPEKK
RTRGLGATTKITTSHPRVPSLTTVPQTQGQTTAQKVSKKTGPRCSTAIATGLKNQKPVPAVPVQKSGTSGVPPMAGGKKPSKRPAWDLKG
QLCDLNAELKRCRERTQTLDQENQQLQDQLRDAQQQVKALGTERTTLEGHLAKVQAQAEQGQQELKNLRACVLELEERLSTQEGLVQELQ
KKQVELQEERRGLMSQLEEKERRLQTSEAALSSSQAEVASLRQETVAQAALLTEREERLHGLEMERRRLHNQLQELKGNIRVFCRVRPVL
PGEPTPPPGLLLFPSGPGGPSDPPTRLSLSRSDERRGTLSGAPAPPTRHDFSFDRVFPPGSGQDEVFEEIAMLVQSALDGYPVCIFAYGQ
TGSGKTFTMEGGPGGDPQLEGLIPRALRHLFSVAQELSGQGWTYSFVASYVEIYNETVRDLLATGTRKGQGGECEIRRAGPGSEELTVTN
ARYVPVSCEKEVDALLHLARQNRAVARTAQNERSSRSHSVFQLQISGEHSSRGLQCGAPLSLVDLAGSERLDPGLALGPGERERLRETQA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RPS6KA2-KIFC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RPS6KA2-KIFC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RPS6KA2-KIFC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource