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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RPS6KA3-MAP7D2 (FusionGDB2 ID:78008)

Fusion Gene Summary for RPS6KA3-MAP7D2

check button Fusion gene summary
Fusion gene informationFusion gene name: RPS6KA3-MAP7D2
Fusion gene ID: 78008
HgeneTgene
Gene symbol

RPS6KA3

MAP7D2

Gene ID

6197

256714

Gene nameribosomal protein S6 kinase A3MAP7 domain containing 2
SynonymsCLS|HU-3|ISPK-1|MAPKAPK1B|MRX19|RSK|RSK2|S6K-alpha3|p90-RSK2|pp90RSK2-
Cytomap

Xp22.12

Xp22.12

Type of geneprotein-codingprotein-coding
Descriptionribosomal protein S6 kinase alpha-3MAP kinase-activated protein kinase 1bMAPK-activated protein kinase 1bMAPKAP kinase 1bMAPKAPK-1bRSK-2S6K-alpha-3epididymis secretory sperm binding proteininsulin-stimulated protein kinase 1p90-RSK 3ribosomal S6MAP7 domain-containing protein 2MAP7 domain containing 2 brainMAP7 domain containing 2 protein varaint 1MAP7 domain containing 2 protein varaint 2MAP7 domain-containing protein 2 brain specific variant 1MAP7 domain-containing protein 2 brain specific
Modification date2020032720200313
UniProtAcc.

Q96T17

Ensembl transtripts involved in fusion geneENST00000379565, ENST00000540702, 
ENST00000544447, ENST00000379548, 
ENST00000479809, 		ENST00000452324, 
ENST00000443379, ENST00000466145, 
ENST00000543767, ENST00000379643, 
ENST00000379651, 
Fusion gene scores* DoF score15 X 11 X 7=11555 X 6 X 5=150
# samples 199
** MAII scorelog2(19/1155*10)=-2.60382152797247
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/150*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPS6KA3 [Title/Abstract] AND MAP7D2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRPS6KA3(20284681)-MAP7D2(20082923), # samples:1
RPS6KA3(20284681)-MAP7D2(20044070), # samples:1
RPS6KA3(20284682)-MAP7D2(20082923), # samples:1
RPS6KA3(20284682)-MAP7D2(20044070), # samples:1
RPS6KA3(20252876)-MAP7D2(20074909), # samples:1
Anticipated loss of major functional domain due to fusion event.RPS6KA3-MAP7D2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
RPS6KA3-MAP7D2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
RPS6KA3-MAP7D2 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPS6KA3

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

18402937


check buttonFusion gene breakpoints across RPS6KA3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MAP7D2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-EA-A411-01ARPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
ChimerDB4CESCTCGA-EA-A411RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
ChimerDB4LIHCTCGA-CC-A123RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
ChimerDB4LIHCTCGA-CC-A123RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
ChimerDB4SARCTCGA-X6-A8C6-01ARPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-


Top

Fusion Gene ORF analysis for RPS6KA3-MAP7D2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000379565ENST00000452324RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
5CDS-5UTRENST00000379565ENST00000452324RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
5CDS-intronENST00000379565ENST00000443379RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
5CDS-intronENST00000379565ENST00000443379RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
5CDS-intronENST00000379565ENST00000443379RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
5CDS-intronENST00000379565ENST00000452324RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
5CDS-intronENST00000379565ENST00000466145RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
5CDS-intronENST00000379565ENST00000466145RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
5CDS-intronENST00000379565ENST00000466145RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
5CDS-intronENST00000379565ENST00000466145RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
5CDS-intronENST00000379565ENST00000466145RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
5CDS-intronENST00000379565ENST00000543767RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
5CDS-intronENST00000379565ENST00000543767RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
5CDS-intronENST00000379565ENST00000543767RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
5CDS-intronENST00000540702ENST00000443379RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
5CDS-intronENST00000540702ENST00000452324RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
5CDS-intronENST00000540702ENST00000466145RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
5CDS-intronENST00000540702ENST00000543767RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
5CDS-intronENST00000544447ENST00000443379RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
5CDS-intronENST00000544447ENST00000452324RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
5CDS-intronENST00000544447ENST00000466145RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
5CDS-intronENST00000544447ENST00000543767RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
Frame-shiftENST00000379565ENST00000379643RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
Frame-shiftENST00000379565ENST00000379643RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
Frame-shiftENST00000379565ENST00000379651RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
Frame-shiftENST00000379565ENST00000379651RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
Frame-shiftENST00000379565ENST00000443379RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
Frame-shiftENST00000379565ENST00000443379RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
Frame-shiftENST00000379565ENST00000452324RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
Frame-shiftENST00000379565ENST00000452324RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
Frame-shiftENST00000379565ENST00000543767RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
Frame-shiftENST00000379565ENST00000543767RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
Frame-shiftENST00000544447ENST00000379643RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
Frame-shiftENST00000544447ENST00000379651RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
In-frameENST00000379565ENST00000379643RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
In-frameENST00000379565ENST00000379643RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
In-frameENST00000379565ENST00000379643RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
In-frameENST00000379565ENST00000379651RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
In-frameENST00000379565ENST00000379651RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
In-frameENST00000379565ENST00000379651RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
In-frameENST00000540702ENST00000379643RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
In-frameENST00000540702ENST00000379651RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
intron-3CDSENST00000379548ENST00000379643RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
intron-3CDSENST00000379548ENST00000379643RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
intron-3CDSENST00000379548ENST00000379643RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
intron-3CDSENST00000379548ENST00000379643RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
intron-3CDSENST00000379548ENST00000379643RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
intron-3CDSENST00000379548ENST00000379651RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
intron-3CDSENST00000379548ENST00000379651RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
intron-3CDSENST00000379548ENST00000379651RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
intron-3CDSENST00000379548ENST00000379651RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
intron-3CDSENST00000379548ENST00000379651RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
intron-3CDSENST00000379548ENST00000443379RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
intron-3CDSENST00000379548ENST00000443379RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
intron-3CDSENST00000379548ENST00000452324RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
intron-3CDSENST00000379548ENST00000452324RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
intron-3CDSENST00000379548ENST00000543767RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
intron-3CDSENST00000379548ENST00000543767RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
intron-3CDSENST00000479809ENST00000379643RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
intron-3CDSENST00000479809ENST00000379643RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
intron-3CDSENST00000479809ENST00000379643RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
intron-3CDSENST00000479809ENST00000379643RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
intron-3CDSENST00000479809ENST00000379643RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
intron-3CDSENST00000479809ENST00000379651RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
intron-3CDSENST00000479809ENST00000379651RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
intron-3CDSENST00000479809ENST00000379651RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
intron-3CDSENST00000479809ENST00000379651RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
intron-3CDSENST00000479809ENST00000379651RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
intron-3CDSENST00000479809ENST00000443379RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
intron-3CDSENST00000479809ENST00000443379RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
intron-3CDSENST00000479809ENST00000452324RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
intron-3CDSENST00000479809ENST00000452324RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
intron-3CDSENST00000479809ENST00000543767RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
intron-3CDSENST00000479809ENST00000543767RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
intron-3CDSENST00000540702ENST00000379643RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
intron-3CDSENST00000540702ENST00000379643RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
intron-3CDSENST00000540702ENST00000379643RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
intron-3CDSENST00000540702ENST00000379643RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
intron-3CDSENST00000540702ENST00000379651RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
intron-3CDSENST00000540702ENST00000379651RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
intron-3CDSENST00000540702ENST00000379651RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
intron-3CDSENST00000540702ENST00000379651RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
intron-3CDSENST00000540702ENST00000443379RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
intron-3CDSENST00000540702ENST00000443379RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
intron-3CDSENST00000540702ENST00000452324RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
intron-3CDSENST00000540702ENST00000452324RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
intron-3CDSENST00000540702ENST00000543767RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
intron-3CDSENST00000540702ENST00000543767RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
intron-3CDSENST00000544447ENST00000379643RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
intron-3CDSENST00000544447ENST00000379643RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
intron-3CDSENST00000544447ENST00000379643RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
intron-3CDSENST00000544447ENST00000379643RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
intron-3CDSENST00000544447ENST00000379651RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
intron-3CDSENST00000544447ENST00000379651RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
intron-3CDSENST00000544447ENST00000379651RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
intron-3CDSENST00000544447ENST00000379651RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
intron-3CDSENST00000544447ENST00000443379RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
intron-3CDSENST00000544447ENST00000443379RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
intron-3CDSENST00000544447ENST00000452324RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
intron-3CDSENST00000544447ENST00000452324RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
intron-3CDSENST00000544447ENST00000543767RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
intron-3CDSENST00000544447ENST00000543767RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
intron-5UTRENST00000379548ENST00000452324RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
intron-5UTRENST00000379548ENST00000452324RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
intron-5UTRENST00000479809ENST00000452324RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
intron-5UTRENST00000479809ENST00000452324RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
intron-5UTRENST00000540702ENST00000452324RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
intron-5UTRENST00000540702ENST00000452324RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
intron-5UTRENST00000544447ENST00000452324RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
intron-5UTRENST00000544447ENST00000452324RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
intron-intronENST00000379548ENST00000443379RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
intron-intronENST00000379548ENST00000443379RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
intron-intronENST00000379548ENST00000443379RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
intron-intronENST00000379548ENST00000452324RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
intron-intronENST00000379548ENST00000466145RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
intron-intronENST00000379548ENST00000466145RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
intron-intronENST00000379548ENST00000466145RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
intron-intronENST00000379548ENST00000466145RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
intron-intronENST00000379548ENST00000466145RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
intron-intronENST00000379548ENST00000543767RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
intron-intronENST00000379548ENST00000543767RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
intron-intronENST00000379548ENST00000543767RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
intron-intronENST00000479809ENST00000443379RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
intron-intronENST00000479809ENST00000443379RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
intron-intronENST00000479809ENST00000443379RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
intron-intronENST00000479809ENST00000452324RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
intron-intronENST00000479809ENST00000466145RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
intron-intronENST00000479809ENST00000466145RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
intron-intronENST00000479809ENST00000466145RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
intron-intronENST00000479809ENST00000466145RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
intron-intronENST00000479809ENST00000466145RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
intron-intronENST00000479809ENST00000543767RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
intron-intronENST00000479809ENST00000543767RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
intron-intronENST00000479809ENST00000543767RPS6KA3chrX

20252876

-MAP7D2chrX

20074909

-
intron-intronENST00000540702ENST00000443379RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
intron-intronENST00000540702ENST00000443379RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
intron-intronENST00000540702ENST00000466145RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
intron-intronENST00000540702ENST00000466145RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
intron-intronENST00000540702ENST00000466145RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
intron-intronENST00000540702ENST00000466145RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
intron-intronENST00000540702ENST00000543767RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
intron-intronENST00000540702ENST00000543767RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
intron-intronENST00000544447ENST00000443379RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
intron-intronENST00000544447ENST00000443379RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
intron-intronENST00000544447ENST00000466145RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
intron-intronENST00000544447ENST00000466145RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-
intron-intronENST00000544447ENST00000466145RPS6KA3chrX

20284681

-MAP7D2chrX

20044070

-
intron-intronENST00000544447ENST00000466145RPS6KA3chrX

20284682

-MAP7D2chrX

20044070

-
intron-intronENST00000544447ENST00000543767RPS6KA3chrX

20284682

-MAP7D2chrX

20082923

-
intron-intronENST00000544447ENST00000543767RPS6KA3chrX

20284681

-MAP7D2chrX

20082923

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000379565RPS6KA3chrX20284681-ENST00000379651MAP7D2chrX20082923-40582772792345688
ENST00000379565RPS6KA3chrX20284681-ENST00000379643MAP7D2chrX20082923-40272772792468729
ENST00000379565RPS6KA3chrX20284682-ENST00000379651MAP7D2chrX20082923-40582772792345688
ENST00000379565RPS6KA3chrX20284682-ENST00000379643MAP7D2chrX20082923-40272772792468729
ENST00000379565RPS6KA3chrX20252876-ENST00000379651MAP7D2chrX20074909-38733342082160650
ENST00000379565RPS6KA3chrX20252876-ENST00000379643MAP7D2chrX20074909-38423342082283691
ENST00000540702RPS6KA3chrX20252876-ENST00000379651MAP7D2chrX20074909-37291901092016635
ENST00000540702RPS6KA3chrX20252876-ENST00000379643MAP7D2chrX20074909-36981901092139676

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379565ENST00000379651RPS6KA3chrX20284681-MAP7D2chrX20082923-0.0008283050.99917173
ENST00000379565ENST00000379643RPS6KA3chrX20284681-MAP7D2chrX20082923-0.0016837660.9983163
ENST00000379565ENST00000379651RPS6KA3chrX20284682-MAP7D2chrX20082923-0.0008283050.99917173
ENST00000379565ENST00000379643RPS6KA3chrX20284682-MAP7D2chrX20082923-0.0016837660.9983163
ENST00000379565ENST00000379651RPS6KA3chrX20252876-MAP7D2chrX20074909-0.0010067770.9989932
ENST00000379565ENST00000379643RPS6KA3chrX20252876-MAP7D2chrX20074909-0.0006974070.9993026
ENST00000540702ENST00000379651RPS6KA3chrX20252876-MAP7D2chrX20074909-0.001100850.9988991
ENST00000540702ENST00000379643RPS6KA3chrX20252876-MAP7D2chrX20074909-0.0007652620.9992348

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Fusion Genomic Features for RPS6KA3-MAP7D2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RPS6KA3-MAP7D2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:20284681/chrX:20082923)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MAP7D2

Q96T17

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMAP7D2chrX:20284681chrX:20082923ENST0000037964301751_146431294.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneMAP7D2chrX:20284681chrX:20082923ENST0000037965101651_146431311.3333333333333Coiled coilOntology_term=ECO:0000255
TgeneMAP7D2chrX:20284681chrX:20082923ENST0000044337901551_14643822.6666666666666Coiled coilOntology_term=ECO:0000255
TgeneMAP7D2chrX:20284681chrX:20082923ENST0000045232401651_1460733.0Coiled coilOntology_term=ECO:0000255
TgeneMAP7D2chrX:20284682chrX:20082923ENST0000037964301751_146431294.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneMAP7D2chrX:20284682chrX:20082923ENST0000037965101651_146431311.3333333333333Coiled coilOntology_term=ECO:0000255
TgeneMAP7D2chrX:20284682chrX:20082923ENST0000044337901551_14643822.6666666666666Coiled coilOntology_term=ECO:0000255
TgeneMAP7D2chrX:20284682chrX:20082923ENST0000045232401651_1460733.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRPS6KA3chrX:20252876chrX:20074909ENST00000379565-222328_39742741.0DomainAGC-kinase C-terminal
HgeneRPS6KA3chrX:20252876chrX:20074909ENST00000379565-222422_67942741.0DomainProtein kinase 2
HgeneRPS6KA3chrX:20252876chrX:20074909ENST00000379565-22268_32742741.0DomainProtein kinase 1
HgeneRPS6KA3chrX:20284681chrX:20082923ENST00000379565-122328_39723741.0DomainAGC-kinase C-terminal
HgeneRPS6KA3chrX:20284681chrX:20082923ENST00000379565-122422_67923741.0DomainProtein kinase 2
HgeneRPS6KA3chrX:20284681chrX:20082923ENST00000379565-12268_32723741.0DomainProtein kinase 1
HgeneRPS6KA3chrX:20284682chrX:20082923ENST00000379565-122328_39723741.0DomainAGC-kinase C-terminal
HgeneRPS6KA3chrX:20284682chrX:20082923ENST00000379565-122422_67923741.0DomainProtein kinase 2
HgeneRPS6KA3chrX:20284682chrX:20082923ENST00000379565-12268_32723741.0DomainProtein kinase 1
HgeneRPS6KA3chrX:20252876chrX:20074909ENST00000379565-222428_43642741.0Nucleotide bindingATP
HgeneRPS6KA3chrX:20252876chrX:20074909ENST00000379565-22274_8242741.0Nucleotide bindingATP
HgeneRPS6KA3chrX:20284681chrX:20082923ENST00000379565-122428_43623741.0Nucleotide bindingATP
HgeneRPS6KA3chrX:20284681chrX:20082923ENST00000379565-12274_8223741.0Nucleotide bindingATP
HgeneRPS6KA3chrX:20284682chrX:20082923ENST00000379565-122428_43623741.0Nucleotide bindingATP
HgeneRPS6KA3chrX:20284682chrX:20082923ENST00000379565-12274_8223741.0Nucleotide bindingATP
TgeneMAP7D2chrX:20252876chrX:20074909ENST0000037964321751_1461241294.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneMAP7D2chrX:20252876chrX:20074909ENST0000037965121651_1461241311.3333333333333Coiled coilOntology_term=ECO:0000255
TgeneMAP7D2chrX:20252876chrX:20074909ENST0000044337921551_146124822.6666666666666Coiled coilOntology_term=ECO:0000255
TgeneMAP7D2chrX:20252876chrX:20074909ENST0000045232421651_14680733.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for RPS6KA3-MAP7D2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>78008_78008_1_RPS6KA3-MAP7D2_RPS6KA3_chrX_20252876_ENST00000379565_MAP7D2_chrX_20074909_ENST00000379643_length(transcript)=3842nt_BP=334nt
AGGCGCGCGGCTTTCGGGCGGTCGGCGTCGGCGTCGAGCCCTCTCTGGGGCCGCCGCCGCTGCTGCTGCTGCTGCCGCTGCCGCTGCCGC
TGCCGCCGCCGCCGCCGCCGCCGCCGCTGCCGTGGGGCTCGGGCGGCGACGGAGCGGGGCCGGCCGTGGGGCGGGCGGGGAGGGAGGAGG
CGGTGAAGGCGGCGGGCCGGGGGGGAAGATGCCGCTGGCGCAGCTGGCGGACCCGTGGCAGAAGATGGCTGTGGAGAGCCCGTCCGACAG
CGCTGAGAATGGACAGCAAATTATGGATGAACCTATGGGAGAGGAGGAGATTAACCCACAAACTGAACGGCTGGAGGCGATGATGCGCCG
GTCCCTGGAGCGCACACAGCAGCTGGAGCTGAAAAAGAAGTATTCGTGGGGAGCACCACTGGCCATTGGACCCGGAGGACATGATGCATG
TGACAAACTTTCAACATCAACTATGAGTTTGCCAAAGCCAACGGAGCCTCCCATGAATAAACGCCTGTCTTCATCCACCGTGGCAATATC
CTATTCCCCAGACCGAGCTCATCACATGCACCTTAGTCCAATGGAAGCCATTCTTGTTTCGCGACTGTTGACACCCACACAGTCTTCTTT
AGCCAGAAGCAGAGCTTCAGTCATGCTCTCTGGGCAGGCCAATGATTCAGTATTCCATGTCTGTCCTCGTTTAGCTCCTCTTGGCCCTCT
TAACCCTTCTTACAAGTCTTCACCCACTCGAAACATTGAGAAGAAGAAAGCTACATCTACGTCTACATCTGGTGCAGGAGATGTTGGGAA
AGAAGCCCTTTCAGGAGGAGAGGCCTCTCTGGTGGAGAAGGTGAAGCGGGGGCAACGAACAGCAACTTCTCTTCCTGTTGTGAACTTCGG
GTCCCCTCTGAGAAGATGTGAGTTTTCTGGAGGCATTCCTAAGAGACCATCTTCTCCTGTGATATCCAAGACAGCTACTAAAGCTTATCC
ACAGTCTCCAAAGACAACGAAACCTCCCTACCCAGGGTCTCCTGTGAAGTACCGCTTACCTGCCCTTTCTGGCCAAGACATGCCCAAGAG
GAAAGCGGAGAAAGAGAAGAGCAACAAGGAAAGGGAAGGTACCTTGGCTCAGCAGGCTGCTGGCCCGCAAGGAGAGGAAGCCCTAGAGAA
GCATGTAGTGGACAAGCATGCCAGCGAGAAGCATGCTGCTGCCGCAGGAGGGAAAGCCGAAAACAGCGCAGCCTTGGGGAAGCCCACAGC
AGGCACCACTGATGCAGGAGAGGCTGCGAAGATCTTGGCTGAAAAGAGAAGACAGGCCCGGCTGCAGAAGGAACAGGAGGAGCAAGAACG
ACTGGAGAAGGAAGAACAAGATAGGCTGGAGAGAGAGGAATTGAAAAGAAAGGCAGAGGAGGAAAGGCTTCGCCTAGAAGAGGAAGCCCG
AAAGCAGGAAGAAGAAAGGAAGCGGCAGGAAGAGGAAAAGAAAAAACAGGAAGGGGAAGAGAAAAGAAAGGCAGGCGAGGAGGCCAAGCG
GAAGGCTGAGGAGGAGCTGTTGTTGAAAGAAAAGCAAGAACAAGAAAAACAAGAGAAAGCCATGATTGAAAAGCAGAAAGAAGCAGCAGA
AACAAAGGCCCGGGAGGTAGCTGAACAGATGCGTCTCGAGAGAGAACAGATTATGCTGCAGATTGAGCAGGAGAGACTGGAGAGAAAGAA
GAGAATAGATGAAATCATGAAGAGAACAAGGAAAAGTGATGTGTCTCCACAAGTGAAGAAAGAAGACCCCAAAGTGGGGGTCCAGCCTGC
TGTGTGTGTGGAAAAGAAGACAAAACTGGTTGTCCCCAACAAAATGGAAATCAATGGATTGAACACCTGCCAGGAAGTTAATGGTGTGGA
TCACGCTGCCCCAGAAACTTATCCCCAAGACATTTTCTCTAATGGGCTTAAGCCAGCTGGGGGACTCATTCATCTGGATGCCCTTGATGG
GAAATCAAATAGCCTGGATGATTCAACTGAAGAAGTTCAGTCTATGGATGTGAGTCCTGTTTCAAAAGAAGAGCTTATCTCTATCCCGGA
ATTTTCACCAGTGAGTGAAATGATTCCTGGGGTGTCTCTGGACCAAAATGGAACTGGTAATGCCCGAGCACTTCAAGATCTCTTAGATTT
CACTGGTCCCCCGACATTCCCCAAGAGATCCAGTGAAAATCTCAGCCTGGACGACTGTAACAAAAACCTTATCGAAGGATTTAACAGTCC
TGGCCAAGAAACTCCTCTCAACACCTTCTGTTGACAAATACAGCATCCCTTTAATAAAAGGTGTTTGGAGAACCCGTAAAGCTGCTGATA
GTCAAATCCGAGCTACTAGCTGCTTGAAGAAGCTTCTGTCACCCTTACCGCTGGATCCCAAATTATTAGCTCGGAATGTAACTGTATTCC
TAGGTAGTATGTCAAACACTGGCCACTCTTGGTAGAAACCTTGAAACTTTCACCTTGCTGGGCTTTAGCAAAGTTTCCTTTTACAGTTCT
GTTTATGAGCTTCAGCTACTGATAAAGCACTTCCTGAACTTCTCTATTATCATAGTGACCCTCTGAATAACCTGAGTGACTGGCTCGGCA
ATTCGCTTTATAACCATTCTTATTCCCAAAGTTGGAGCACATAAACATTTAGATGTCTTTTCCTGTAAAATATTCTAGACATTTACCCAA
ACTCTAGTTCAACATATACTCAACTTGCACTGTATATCTCCCTGTCTTTTTTGAGACAGAGAAGAAATTCAGGAGGTTCCCCATCTCCAG
AGTTTCTCTGTTGGAAAGCAGTATCAAGAAGCCTTTAAAAAATTGTTGTTAAGCTTTGCCACCTGCAGAAATGCATTGCCCCACATTATT
CTTCTGGGGTTAAAGTAGTAAGTTTGGTTGAGGAAGGAAGTCAAAACAGTCAGTAATGATTTCTGTTCTCTTATGCATATTCGTGTATAC
ATGGGCAACTGAATCTAGCAAGGACTCTTTCGTGTCACACCTTAAAATCTTCATGCTGTAGTCACTCCAGACCATGGAGTGGCTTTCCAG
CTGAATGAATCCTATGTCTCGCGTGCAGGTGGTTGGTTTTCAATGTTCTTGCTAATTTTTTTTCTATTGGATCTTGGGAGTTTTCTTTGT
TTGCTCCTGTGTTTGCCCAGCTTTAATAAAACCAGGCGCAAACAAAAACCATAGCATTCTGAAACAATAGGGGGCCCACATTGGACCCAG
TATGTCACTTTAATGGACTTCAAGAAAAAATCTGAATGGGAAAAATGACACTAGAATGTATACTCCACACATTTTATGCCATATAATGGT
GTGTTTTCTTAATTTTGTTTCTTGTGGCGAAATGTGGCTTTCAAATTAAAATGACCTTTTCTTCTTTGAAACTTTTTGTTTTGACTTGTA
TAATTAAGGGTTTGGAAAGATTCATAATTCTGAGAGAGGTTTGCAACCAGGAGATACAAAGAAGTCTCAGTAGTAATCTTGTTCATGTGC
TTTTACAGCCAGCTACATTTAAGAATGTATTAGTTACAGAAATTATATGTCTGTGTATGTGTCTCTACTCAATAAAGTACATGCCTCCAC
ATAATGCGGTGCTGTCCATCTCGGCAAATACTGGCCAAGTCCCTTTATGACAGGCACACAGAAACCATAGCATGGTCTGGCTTTCAGAAA
ATGCCTCTCATCTTTCCTGGAACCTTATTTTGCTAAATGTCTGTTTTCTTGTGATTTGTTGTACCTCACAGCACCATTGTGACCATGGTG

>78008_78008_1_RPS6KA3-MAP7D2_RPS6KA3_chrX_20252876_ENST00000379565_MAP7D2_chrX_20074909_ENST00000379643_length(amino acids)=691AA_BP=0
MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTERLEAMMRRSLERTQQLELKKKYSWGAPLAIGPGGHDACDKLSTSTMS
LPKPTEPPMNKRLSSSTVAISYSPDRAHHMHLSPMEAILVSRLLTPTQSSLARSRASVMLSGQANDSVFHVCPRLAPLGPLNPSYKSSPT
RNIEKKKATSTSTSGAGDVGKEALSGGEASLVEKVKRGQRTATSLPVVNFGSPLRRCEFSGGIPKRPSSPVISKTATKAYPQSPKTTKPP
YPGSPVKYRLPALSGQDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPTAGTTDAGEAA
KILAEKRRQARLQKEQEEQERLEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLK
EKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVSPQVKKEDPKVGVQPAVCVEKKTKL
VVPNKMEINGLNTCQEVNGVDHAAPETYPQDIFSNGLKPAGGLIHLDALDGKSNSLDDSTEEVQSMDVSPVSKEELISIPEFSPVSEMIP

--------------------------------------------------------------
>78008_78008_2_RPS6KA3-MAP7D2_RPS6KA3_chrX_20252876_ENST00000379565_MAP7D2_chrX_20074909_ENST00000379651_length(transcript)=3873nt_BP=334nt
AGGCGCGCGGCTTTCGGGCGGTCGGCGTCGGCGTCGAGCCCTCTCTGGGGCCGCCGCCGCTGCTGCTGCTGCTGCCGCTGCCGCTGCCGC
TGCCGCCGCCGCCGCCGCCGCCGCCGCTGCCGTGGGGCTCGGGCGGCGACGGAGCGGGGCCGGCCGTGGGGCGGGCGGGGAGGGAGGAGG
CGGTGAAGGCGGCGGGCCGGGGGGGAAGATGCCGCTGGCGCAGCTGGCGGACCCGTGGCAGAAGATGGCTGTGGAGAGCCCGTCCGACAG
CGCTGAGAATGGACAGCAAATTATGGATGAACCTATGGGAGAGGAGGAGATTAACCCACAAACTGAACGGCTGGAGGCGATGATGCGCCG
GTCCCTGGAGCGCACACAGCAGCTGGAGCTGAAAAAGAAGTATTCGTGGGGAGCACCACTGGCCATTGGACCCGGAGGACATGATGCATG
TGACAAACTTTCAACATCAACTATGAGTTTGCCAAAGCCAACGGAGCCTCCCATGAATAAACGCCTGTCTTCATCCACCGTGGCAATATC
CTATTCCCCAGACCGAGTATTCCATGTCTGTCCTCGTTTAGCTCCTCTTGGCCCTCTTAACCCTTCTTACAAGTCTTCACCCACTCGAAA
CATTGAGAAGAAGAAAGCTACATCTACGTCTACATCTGGTGCAGGAGATGTTGGGAAAGAAGCCCTTTCAGGAGGAGAGGCCTCTCTGGT
GGAGAAGGTGAAGCGGGGGCAACGAACAGCAACTTCTCTTCCTGTTGTGAACTTCGGGTCCCCTCTGAGAAGATGTGAGTTTTCTGGAGG
CATTCCTAAGAGACCATCTTCTCCTGTGATATCCAAGACAGCTACTAAAGCTTATCCACAGTCTCCAAAGACAACGAAACCTCCCTACCC
AGGGTCTCCTGTGAAGTACCGCTTACCTGCCCTTTCTGGCCAAGACATGCCCAAGAGGAAAGCGGAGAAAGAGAAGAGCAACAAGGAAAG
GGAAGGTACCTTGGCTCAGCAGGCTGCTGGCCCGCAAGGAGAGGAAGCCCTAGAGAAGCATGTAGTGGACAAGCATGCCAGCGAGAAGCA
TGCTGCTGCCGCAGGAGGGAAAGCCGAAAACAGCGCAGCCTTGGGGAAGCCCACAGCAGGCACCACTGATGCAGGAGAGGCTGCGAAGAT
CTTGGCTGAAAAGAGAAGACAGGCCCGGCTGCAGAAGGAACAGGAGGAGCAAGAACGACTGGAGAAGGAAGAACAAGATAGGCTGGAGAG
AGAGGAATTGAAAAGAAAGGCAGAGGAGGAAAGGCTTCGCCTAGAAGAGGAAGCCCGAAAGCAGGAAGAAGAAAGGAAGCGGCAGGAAGA
GGAAAAGAAAAAACAGGAAGGGGAAGAGAAAAGAAAGGCAGGCGAGGAGGCCAAGCGGAAGGCTGAGGAGGAGCTGTTGTTGAAAGAAAA
GCAAGAACAAGAAAAACAAGAGAAAGCCATGATTGAAAAGCAGAAAGAAGCAGCAGAAACAAAGGCCCGGGAGGTAGCTGAACAGATGCG
TCTCGAGAGAGAACAGATTATGCTGCAGATTGAGCAGGAGAGACTGGAGAGAAAGAAGAGAATAGATGAAATCATGAAGAGAACAAGGAA
AAGTGATGTGTCTCCACAAGTGAAGAAAGAAGACCCCAAAGTGGGGGTCCAGCCTGCTGTGTGTGTGGAAAAGAAGACAAAACTGGTTGT
CCCCAACAAAATGGAAATCAATGGATTGAACACCTGCCAGGAAGTTAATGGTGTGGATCACGCTGCCCCAGAAACTTATCCCCAAGACAT
TTTCTCTAATGGGCTTAAGCCAGCTGGGGGACTCATTCATCTGGATGCCCTTGATGGGAAATCAAATAGCCTGGATGATTCAACTGAAGA
AGTTCAGTCTATGGATGTGAGTCCTGTTTCAAAAGAAGAGCTTATCTCTATCCCGGAATTTTCACCAGTGAGTGAAATGATTCCTGGGGT
GTCTCTGGACCAAAATGGAACTGGTAATGCCCGAGCACTTCAAGATCTCTTAGATTTCACTGGTCCCCCGACATTCCCCAAGAGATCCAG
TGAAAATCTCAGCCTGGACGACTGTAACAAAAACCTTATCGAAGGATTTAACAGTCCTGGCCAAGAAACTCCTCTCAACACCTTCTGTTG
ACAAATACAGCATCCCTTTAATAAAAGGTGTTTGGAGAACCCGTAAAGCTGCTGATAGTCAAATCCGAGCTACTAGCTGCTTGAAGAAGC
TTCTGTCACCCTTACCGCTGGATCCCAAATTATTAGCTCGGAATGTAACTGTATTCCTAGGTAGTATGTCAAACACTGGCCACTCTTGGT
AGAAACCTTGAAACTTTCACCTTGCTGGGCTTTAGCAAAGTTTCCTTTTACAGTTCTGTTTATGAGCTTCAGCTACTGATAAAGCACTTC
CTGAACTTCTCTATTATCATAGTGACCCTCTGAATAACCTGAGTGACTGGCTCGGCAATTCGCTTTATAACCATTCTTATTCCCAAAGTT
GGAGCACATAAACATTTAGATGTCTTTTCCTGTAAAATATTCTAGACATTTACCCAAACTCTAGTTCAACATATACTCAACTTGCACTGT
ATATCTCCCTGTCTTTTTTGAGACAGAGAAGAAATTCAGGAGGTTCCCCATCTCCAGAGTTTCTCTGTTGGAAAGCAGTATCAAGAAGCC
TTTAAAAAATTGTTGTTAAGCTTTGCCACCTGCAGAAATGCATTGCCCCACATTATTCTTCTGGGGTTAAAGTAGTAAGTTTGGTTGAGG
AAGGAAGTCAAAACAGTCAGTAATGATTTCTGTTCTCTTATGCATATTCGTGTATACATGGGCAACTGAATCTAGCAAGGACTCTTTCGT
GTCACACCTTAAAATCTTCATGCTGTAGTCACTCCAGACCATGGAGTGGCTTTCCAGCTGAATGAATCCTATGTCTCGCGTGCAGGTGGT
TGGTTTTCAATGTTCTTGCTAATTTTTTTTCTATTGGATCTTGGGAGTTTTCTTTGTTTGCTCCTGTGTTTGCCCAGCTTTAATAAAACC
AGGCGCAAACAAAAACCATAGCATTCTGAAACAATAGGGGGCCCACATTGGACCCAGTATGTCACTTTAATGGACTTCAAGAAAAAATCT
GAATGGGAAAAATGACACTAGAATGTATACTCCACACATTTTATGCCATATAATGGTGTGTTTTCTTAATTTTGTTTCTTGTGGCGAAAT
GTGGCTTTCAAATTAAAATGACCTTTTCTTCTTTGAAACTTTTTGTTTTGACTTGTATAATTAAGGGTTTGGAAAGATTCATAATTCTGA
GAGAGGTTTGCAACCAGGAGATACAAAGAAGTCTCAGTAGTAATCTTGTTCATGTGCTTTTACAGCCAGCTACATTTAAGAATGTATTAG
TTACAGAAATTATATGTCTGTGTATGTGTCTCTACTCAATAAAGTACATGCCTCCACATAATGCGGTGCTGTCCATCTCGGCAAATACTG
GCCAAGTCCCTTTATGACAGGCACACAGAAACCATAGCATGGTCTGGCTTTCAGAAAATGCCTCTCATCTTTCCTGGAACCTTATTTTGC
TAAATGTCTGTTTTCTTGTGATTTGTTGTACCTCACAGCACCATTGTGACCATGGTGATGCCTCATTTGCATGATATGTACCTTGTGTTT
AATGTGAAATACATTTTCATTGAAGAGTCTGATGACTTGCTAGCGTTTTATTTTTTCTGTAAGCTCAATGTGCTGAAACCAAACCAGGCT
TTTAAAAACCTGTGTAGAAGAAAACCAAAAAATCCTGTGTGGGTGTCCTTTCCCTGTCAAACTCATTAAAAATTCCTTTGTTGCCAGTGC

>78008_78008_2_RPS6KA3-MAP7D2_RPS6KA3_chrX_20252876_ENST00000379565_MAP7D2_chrX_20074909_ENST00000379651_length(amino acids)=650AA_BP=0
MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTERLEAMMRRSLERTQQLELKKKYSWGAPLAIGPGGHDACDKLSTSTMS
LPKPTEPPMNKRLSSSTVAISYSPDRVFHVCPRLAPLGPLNPSYKSSPTRNIEKKKATSTSTSGAGDVGKEALSGGEASLVEKVKRGQRT
ATSLPVVNFGSPLRRCEFSGGIPKRPSSPVISKTATKAYPQSPKTTKPPYPGSPVKYRLPALSGQDMPKRKAEKEKSNKEREGTLAQQAA
GPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERLEKEEQDRLEREELKRKAEE
ERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQ
IEQERLERKKRIDEIMKRTRKSDVSPQVKKEDPKVGVQPAVCVEKKTKLVVPNKMEINGLNTCQEVNGVDHAAPETYPQDIFSNGLKPAG
GLIHLDALDGKSNSLDDSTEEVQSMDVSPVSKEELISIPEFSPVSEMIPGVSLDQNGTGNARALQDLLDFTGPPTFPKRSSENLSLDDCN

--------------------------------------------------------------
>78008_78008_3_RPS6KA3-MAP7D2_RPS6KA3_chrX_20252876_ENST00000540702_MAP7D2_chrX_20074909_ENST00000379643_length(transcript)=3698nt_BP=190nt
AGGATTATATCTTTATCCTTGAAATTTAAAAACATTTGCCAGGACATGTCTTGGTGTTGATGATCTCTGTTGAACCTTCTCAGTCTCCAG
TCTCAGGATAAATGAGGAGCTGATTCTTAATCCTGTCACATTGAATGGACAGCAAATTATGGATGAACCTATGGGAGAGGAGGAGATTAA
CCCACAAACTGAACGGCTGGAGGCGATGATGCGCCGGTCCCTGGAGCGCACACAGCAGCTGGAGCTGAAAAAGAAGTATTCGTGGGGAGC
ACCACTGGCCATTGGACCCGGAGGACATGATGCATGTGACAAACTTTCAACATCAACTATGAGTTTGCCAAAGCCAACGGAGCCTCCCAT
GAATAAACGCCTGTCTTCATCCACCGTGGCAATATCCTATTCCCCAGACCGAGCTCATCACATGCACCTTAGTCCAATGGAAGCCATTCT
TGTTTCGCGACTGTTGACACCCACACAGTCTTCTTTAGCCAGAAGCAGAGCTTCAGTCATGCTCTCTGGGCAGGCCAATGATTCAGTATT
CCATGTCTGTCCTCGTTTAGCTCCTCTTGGCCCTCTTAACCCTTCTTACAAGTCTTCACCCACTCGAAACATTGAGAAGAAGAAAGCTAC
ATCTACGTCTACATCTGGTGCAGGAGATGTTGGGAAAGAAGCCCTTTCAGGAGGAGAGGCCTCTCTGGTGGAGAAGGTGAAGCGGGGGCA
ACGAACAGCAACTTCTCTTCCTGTTGTGAACTTCGGGTCCCCTCTGAGAAGATGTGAGTTTTCTGGAGGCATTCCTAAGAGACCATCTTC
TCCTGTGATATCCAAGACAGCTACTAAAGCTTATCCACAGTCTCCAAAGACAACGAAACCTCCCTACCCAGGGTCTCCTGTGAAGTACCG
CTTACCTGCCCTTTCTGGCCAAGACATGCCCAAGAGGAAAGCGGAGAAAGAGAAGAGCAACAAGGAAAGGGAAGGTACCTTGGCTCAGCA
GGCTGCTGGCCCGCAAGGAGAGGAAGCCCTAGAGAAGCATGTAGTGGACAAGCATGCCAGCGAGAAGCATGCTGCTGCCGCAGGAGGGAA
AGCCGAAAACAGCGCAGCCTTGGGGAAGCCCACAGCAGGCACCACTGATGCAGGAGAGGCTGCGAAGATCTTGGCTGAAAAGAGAAGACA
GGCCCGGCTGCAGAAGGAACAGGAGGAGCAAGAACGACTGGAGAAGGAAGAACAAGATAGGCTGGAGAGAGAGGAATTGAAAAGAAAGGC
AGAGGAGGAAAGGCTTCGCCTAGAAGAGGAAGCCCGAAAGCAGGAAGAAGAAAGGAAGCGGCAGGAAGAGGAAAAGAAAAAACAGGAAGG
GGAAGAGAAAAGAAAGGCAGGCGAGGAGGCCAAGCGGAAGGCTGAGGAGGAGCTGTTGTTGAAAGAAAAGCAAGAACAAGAAAAACAAGA
GAAAGCCATGATTGAAAAGCAGAAAGAAGCAGCAGAAACAAAGGCCCGGGAGGTAGCTGAACAGATGCGTCTCGAGAGAGAACAGATTAT
GCTGCAGATTGAGCAGGAGAGACTGGAGAGAAAGAAGAGAATAGATGAAATCATGAAGAGAACAAGGAAAAGTGATGTGTCTCCACAAGT
GAAGAAAGAAGACCCCAAAGTGGGGGTCCAGCCTGCTGTGTGTGTGGAAAAGAAGACAAAACTGGTTGTCCCCAACAAAATGGAAATCAA
TGGATTGAACACCTGCCAGGAAGTTAATGGTGTGGATCACGCTGCCCCAGAAACTTATCCCCAAGACATTTTCTCTAATGGGCTTAAGCC
AGCTGGGGGACTCATTCATCTGGATGCCCTTGATGGGAAATCAAATAGCCTGGATGATTCAACTGAAGAAGTTCAGTCTATGGATGTGAG
TCCTGTTTCAAAAGAAGAGCTTATCTCTATCCCGGAATTTTCACCAGTGAGTGAAATGATTCCTGGGGTGTCTCTGGACCAAAATGGAAC
TGGTAATGCCCGAGCACTTCAAGATCTCTTAGATTTCACTGGTCCCCCGACATTCCCCAAGAGATCCAGTGAAAATCTCAGCCTGGACGA
CTGTAACAAAAACCTTATCGAAGGATTTAACAGTCCTGGCCAAGAAACTCCTCTCAACACCTTCTGTTGACAAATACAGCATCCCTTTAA
TAAAAGGTGTTTGGAGAACCCGTAAAGCTGCTGATAGTCAAATCCGAGCTACTAGCTGCTTGAAGAAGCTTCTGTCACCCTTACCGCTGG
ATCCCAAATTATTAGCTCGGAATGTAACTGTATTCCTAGGTAGTATGTCAAACACTGGCCACTCTTGGTAGAAACCTTGAAACTTTCACC
TTGCTGGGCTTTAGCAAAGTTTCCTTTTACAGTTCTGTTTATGAGCTTCAGCTACTGATAAAGCACTTCCTGAACTTCTCTATTATCATA
GTGACCCTCTGAATAACCTGAGTGACTGGCTCGGCAATTCGCTTTATAACCATTCTTATTCCCAAAGTTGGAGCACATAAACATTTAGAT
GTCTTTTCCTGTAAAATATTCTAGACATTTACCCAAACTCTAGTTCAACATATACTCAACTTGCACTGTATATCTCCCTGTCTTTTTTGA
GACAGAGAAGAAATTCAGGAGGTTCCCCATCTCCAGAGTTTCTCTGTTGGAAAGCAGTATCAAGAAGCCTTTAAAAAATTGTTGTTAAGC
TTTGCCACCTGCAGAAATGCATTGCCCCACATTATTCTTCTGGGGTTAAAGTAGTAAGTTTGGTTGAGGAAGGAAGTCAAAACAGTCAGT
AATGATTTCTGTTCTCTTATGCATATTCGTGTATACATGGGCAACTGAATCTAGCAAGGACTCTTTCGTGTCACACCTTAAAATCTTCAT
GCTGTAGTCACTCCAGACCATGGAGTGGCTTTCCAGCTGAATGAATCCTATGTCTCGCGTGCAGGTGGTTGGTTTTCAATGTTCTTGCTA
ATTTTTTTTCTATTGGATCTTGGGAGTTTTCTTTGTTTGCTCCTGTGTTTGCCCAGCTTTAATAAAACCAGGCGCAAACAAAAACCATAG
CATTCTGAAACAATAGGGGGCCCACATTGGACCCAGTATGTCACTTTAATGGACTTCAAGAAAAAATCTGAATGGGAAAAATGACACTAG
AATGTATACTCCACACATTTTATGCCATATAATGGTGTGTTTTCTTAATTTTGTTTCTTGTGGCGAAATGTGGCTTTCAAATTAAAATGA
CCTTTTCTTCTTTGAAACTTTTTGTTTTGACTTGTATAATTAAGGGTTTGGAAAGATTCATAATTCTGAGAGAGGTTTGCAACCAGGAGA
TACAAAGAAGTCTCAGTAGTAATCTTGTTCATGTGCTTTTACAGCCAGCTACATTTAAGAATGTATTAGTTACAGAAATTATATGTCTGT
GTATGTGTCTCTACTCAATAAAGTACATGCCTCCACATAATGCGGTGCTGTCCATCTCGGCAAATACTGGCCAAGTCCCTTTATGACAGG
CACACAGAAACCATAGCATGGTCTGGCTTTCAGAAAATGCCTCTCATCTTTCCTGGAACCTTATTTTGCTAAATGTCTGTTTTCTTGTGA
TTTGTTGTACCTCACAGCACCATTGTGACCATGGTGATGCCTCATTTGCATGATATGTACCTTGTGTTTAATGTGAAATACATTTTCATT

>78008_78008_3_RPS6KA3-MAP7D2_RPS6KA3_chrX_20252876_ENST00000540702_MAP7D2_chrX_20074909_ENST00000379643_length(amino acids)=676AA_BP=8
MILNPVTLNGQQIMDEPMGEEEINPQTERLEAMMRRSLERTQQLELKKKYSWGAPLAIGPGGHDACDKLSTSTMSLPKPTEPPMNKRLSS
STVAISYSPDRAHHMHLSPMEAILVSRLLTPTQSSLARSRASVMLSGQANDSVFHVCPRLAPLGPLNPSYKSSPTRNIEKKKATSTSTSG
AGDVGKEALSGGEASLVEKVKRGQRTATSLPVVNFGSPLRRCEFSGGIPKRPSSPVISKTATKAYPQSPKTTKPPYPGSPVKYRLPALSG
QDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKE
QEEQERLEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEK
QKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVSPQVKKEDPKVGVQPAVCVEKKTKLVVPNKMEINGLNTCQ
EVNGVDHAAPETYPQDIFSNGLKPAGGLIHLDALDGKSNSLDDSTEEVQSMDVSPVSKEELISIPEFSPVSEMIPGVSLDQNGTGNARAL

--------------------------------------------------------------
>78008_78008_4_RPS6KA3-MAP7D2_RPS6KA3_chrX_20252876_ENST00000540702_MAP7D2_chrX_20074909_ENST00000379651_length(transcript)=3729nt_BP=190nt
AGGATTATATCTTTATCCTTGAAATTTAAAAACATTTGCCAGGACATGTCTTGGTGTTGATGATCTCTGTTGAACCTTCTCAGTCTCCAG
TCTCAGGATAAATGAGGAGCTGATTCTTAATCCTGTCACATTGAATGGACAGCAAATTATGGATGAACCTATGGGAGAGGAGGAGATTAA
CCCACAAACTGAACGGCTGGAGGCGATGATGCGCCGGTCCCTGGAGCGCACACAGCAGCTGGAGCTGAAAAAGAAGTATTCGTGGGGAGC
ACCACTGGCCATTGGACCCGGAGGACATGATGCATGTGACAAACTTTCAACATCAACTATGAGTTTGCCAAAGCCAACGGAGCCTCCCAT
GAATAAACGCCTGTCTTCATCCACCGTGGCAATATCCTATTCCCCAGACCGAGTATTCCATGTCTGTCCTCGTTTAGCTCCTCTTGGCCC
TCTTAACCCTTCTTACAAGTCTTCACCCACTCGAAACATTGAGAAGAAGAAAGCTACATCTACGTCTACATCTGGTGCAGGAGATGTTGG
GAAAGAAGCCCTTTCAGGAGGAGAGGCCTCTCTGGTGGAGAAGGTGAAGCGGGGGCAACGAACAGCAACTTCTCTTCCTGTTGTGAACTT
CGGGTCCCCTCTGAGAAGATGTGAGTTTTCTGGAGGCATTCCTAAGAGACCATCTTCTCCTGTGATATCCAAGACAGCTACTAAAGCTTA
TCCACAGTCTCCAAAGACAACGAAACCTCCCTACCCAGGGTCTCCTGTGAAGTACCGCTTACCTGCCCTTTCTGGCCAAGACATGCCCAA
GAGGAAAGCGGAGAAAGAGAAGAGCAACAAGGAAAGGGAAGGTACCTTGGCTCAGCAGGCTGCTGGCCCGCAAGGAGAGGAAGCCCTAGA
GAAGCATGTAGTGGACAAGCATGCCAGCGAGAAGCATGCTGCTGCCGCAGGAGGGAAAGCCGAAAACAGCGCAGCCTTGGGGAAGCCCAC
AGCAGGCACCACTGATGCAGGAGAGGCTGCGAAGATCTTGGCTGAAAAGAGAAGACAGGCCCGGCTGCAGAAGGAACAGGAGGAGCAAGA
ACGACTGGAGAAGGAAGAACAAGATAGGCTGGAGAGAGAGGAATTGAAAAGAAAGGCAGAGGAGGAAAGGCTTCGCCTAGAAGAGGAAGC
CCGAAAGCAGGAAGAAGAAAGGAAGCGGCAGGAAGAGGAAAAGAAAAAACAGGAAGGGGAAGAGAAAAGAAAGGCAGGCGAGGAGGCCAA
GCGGAAGGCTGAGGAGGAGCTGTTGTTGAAAGAAAAGCAAGAACAAGAAAAACAAGAGAAAGCCATGATTGAAAAGCAGAAAGAAGCAGC
AGAAACAAAGGCCCGGGAGGTAGCTGAACAGATGCGTCTCGAGAGAGAACAGATTATGCTGCAGATTGAGCAGGAGAGACTGGAGAGAAA
GAAGAGAATAGATGAAATCATGAAGAGAACAAGGAAAAGTGATGTGTCTCCACAAGTGAAGAAAGAAGACCCCAAAGTGGGGGTCCAGCC
TGCTGTGTGTGTGGAAAAGAAGACAAAACTGGTTGTCCCCAACAAAATGGAAATCAATGGATTGAACACCTGCCAGGAAGTTAATGGTGT
GGATCACGCTGCCCCAGAAACTTATCCCCAAGACATTTTCTCTAATGGGCTTAAGCCAGCTGGGGGACTCATTCATCTGGATGCCCTTGA
TGGGAAATCAAATAGCCTGGATGATTCAACTGAAGAAGTTCAGTCTATGGATGTGAGTCCTGTTTCAAAAGAAGAGCTTATCTCTATCCC
GGAATTTTCACCAGTGAGTGAAATGATTCCTGGGGTGTCTCTGGACCAAAATGGAACTGGTAATGCCCGAGCACTTCAAGATCTCTTAGA
TTTCACTGGTCCCCCGACATTCCCCAAGAGATCCAGTGAAAATCTCAGCCTGGACGACTGTAACAAAAACCTTATCGAAGGATTTAACAG
TCCTGGCCAAGAAACTCCTCTCAACACCTTCTGTTGACAAATACAGCATCCCTTTAATAAAAGGTGTTTGGAGAACCCGTAAAGCTGCTG
ATAGTCAAATCCGAGCTACTAGCTGCTTGAAGAAGCTTCTGTCACCCTTACCGCTGGATCCCAAATTATTAGCTCGGAATGTAACTGTAT
TCCTAGGTAGTATGTCAAACACTGGCCACTCTTGGTAGAAACCTTGAAACTTTCACCTTGCTGGGCTTTAGCAAAGTTTCCTTTTACAGT
TCTGTTTATGAGCTTCAGCTACTGATAAAGCACTTCCTGAACTTCTCTATTATCATAGTGACCCTCTGAATAACCTGAGTGACTGGCTCG
GCAATTCGCTTTATAACCATTCTTATTCCCAAAGTTGGAGCACATAAACATTTAGATGTCTTTTCCTGTAAAATATTCTAGACATTTACC
CAAACTCTAGTTCAACATATACTCAACTTGCACTGTATATCTCCCTGTCTTTTTTGAGACAGAGAAGAAATTCAGGAGGTTCCCCATCTC
CAGAGTTTCTCTGTTGGAAAGCAGTATCAAGAAGCCTTTAAAAAATTGTTGTTAAGCTTTGCCACCTGCAGAAATGCATTGCCCCACATT
ATTCTTCTGGGGTTAAAGTAGTAAGTTTGGTTGAGGAAGGAAGTCAAAACAGTCAGTAATGATTTCTGTTCTCTTATGCATATTCGTGTA
TACATGGGCAACTGAATCTAGCAAGGACTCTTTCGTGTCACACCTTAAAATCTTCATGCTGTAGTCACTCCAGACCATGGAGTGGCTTTC
CAGCTGAATGAATCCTATGTCTCGCGTGCAGGTGGTTGGTTTTCAATGTTCTTGCTAATTTTTTTTCTATTGGATCTTGGGAGTTTTCTT
TGTTTGCTCCTGTGTTTGCCCAGCTTTAATAAAACCAGGCGCAAACAAAAACCATAGCATTCTGAAACAATAGGGGGCCCACATTGGACC
CAGTATGTCACTTTAATGGACTTCAAGAAAAAATCTGAATGGGAAAAATGACACTAGAATGTATACTCCACACATTTTATGCCATATAAT
GGTGTGTTTTCTTAATTTTGTTTCTTGTGGCGAAATGTGGCTTTCAAATTAAAATGACCTTTTCTTCTTTGAAACTTTTTGTTTTGACTT
GTATAATTAAGGGTTTGGAAAGATTCATAATTCTGAGAGAGGTTTGCAACCAGGAGATACAAAGAAGTCTCAGTAGTAATCTTGTTCATG
TGCTTTTACAGCCAGCTACATTTAAGAATGTATTAGTTACAGAAATTATATGTCTGTGTATGTGTCTCTACTCAATAAAGTACATGCCTC
CACATAATGCGGTGCTGTCCATCTCGGCAAATACTGGCCAAGTCCCTTTATGACAGGCACACAGAAACCATAGCATGGTCTGGCTTTCAG
AAAATGCCTCTCATCTTTCCTGGAACCTTATTTTGCTAAATGTCTGTTTTCTTGTGATTTGTTGTACCTCACAGCACCATTGTGACCATG
GTGATGCCTCATTTGCATGATATGTACCTTGTGTTTAATGTGAAATACATTTTCATTGAAGAGTCTGATGACTTGCTAGCGTTTTATTTT
TTCTGTAAGCTCAATGTGCTGAAACCAAACCAGGCTTTTAAAAACCTGTGTAGAAGAAAACCAAAAAATCCTGTGTGGGTGTCCTTTCCC

>78008_78008_4_RPS6KA3-MAP7D2_RPS6KA3_chrX_20252876_ENST00000540702_MAP7D2_chrX_20074909_ENST00000379651_length(amino acids)=635AA_BP=8
MILNPVTLNGQQIMDEPMGEEEINPQTERLEAMMRRSLERTQQLELKKKYSWGAPLAIGPGGHDACDKLSTSTMSLPKPTEPPMNKRLSS
STVAISYSPDRVFHVCPRLAPLGPLNPSYKSSPTRNIEKKKATSTSTSGAGDVGKEALSGGEASLVEKVKRGQRTATSLPVVNFGSPLRR
CEFSGGIPKRPSSPVISKTATKAYPQSPKTTKPPYPGSPVKYRLPALSGQDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDK
HASEKHAAAAGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERLEKEEQDRLEREELKRKAEEERLRLEEEARKQEEE
RKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEI
MKRTRKSDVSPQVKKEDPKVGVQPAVCVEKKTKLVVPNKMEINGLNTCQEVNGVDHAAPETYPQDIFSNGLKPAGGLIHLDALDGKSNSL
DDSTEEVQSMDVSPVSKEELISIPEFSPVSEMIPGVSLDQNGTGNARALQDLLDFTGPPTFPKRSSENLSLDDCNKNLIEGFNSPGQETP

--------------------------------------------------------------
>78008_78008_5_RPS6KA3-MAP7D2_RPS6KA3_chrX_20284681_ENST00000379565_MAP7D2_chrX_20082923_ENST00000379643_length(transcript)=4027nt_BP=277nt
AGGCGCGCGGCTTTCGGGCGGTCGGCGTCGGCGTCGAGCCCTCTCTGGGGCCGCCGCCGCTGCTGCTGCTGCTGCCGCTGCCGCTGCCGC
TGCCGCCGCCGCCGCCGCCGCCGCCGCTGCCGTGGGGCTCGGGCGGCGACGGAGCGGGGCCGGCCGTGGGGCGGGCGGGGAGGGAGGAGG
CGGTGAAGGCGGCGGGCCGGGGGGGAAGATGCCGCTGGCGCAGCTGGCGGACCCGTGGCAGAAGATGGCTGTGGAGAGCCCGTCCGACAG
CGCTGAGGCATGGAGGGATTTTTGAAATCAGATGAGAGGCAGAGATTGGCCAAAGAAAGACGAGAAGAAAGAGAAAAATGTCTGGCTGCT
CGGGAGCAACAGATCCTGGAGAAACAGAAAAGAGCCAGGCTGCAGTACGAAAAGCAAATGGAGGAGCGATGGCGAAAACTGGAAGAGCAG
CGGCAGCGGGAGGACCAAAAGAGAGCTGCTGTGGAAGAGAAAAGGAAACAGAAGCTCCGGGAGGAGGAGGAACGGCTGGAGGCGATGATG
CGCCGGTCCCTGGAGCGCACACAGCAGCTGGAGCTGAAAAAGAAGTATTCGTGGGGAGCACCACTGGCCATTGGACCCGGAGGACATGAT
GCATGTGACAAACTTTCAACATCAACTATGAGTTTGCCAAAGCCAACGGAGCCTCCCATGAATAAACGCCTGTCTTCATCCACCGTGGCA
ATATCCTATTCCCCAGACCGAGCTCATCACATGCACCTTAGTCCAATGGAAGCCATTCTTGTTTCGCGACTGTTGACACCCACACAGTCT
TCTTTAGCCAGAAGCAGAGCTTCAGTCATGCTCTCTGGGCAGGCCAATGATTCAGTATTCCATGTCTGTCCTCGTTTAGCTCCTCTTGGC
CCTCTTAACCCTTCTTACAAGTCTTCACCCACTCGAAACATTGAGAAGAAGAAAGCTACATCTACGTCTACATCTGGTGCAGGAGATGTT
GGGAAAGAAGCCCTTTCAGGAGGAGAGGCCTCTCTGGTGGAGAAGGTGAAGCGGGGGCAACGAACAGCAACTTCTCTTCCTGTTGTGAAC
TTCGGGTCCCCTCTGAGAAGATGTGAGTTTTCTGGAGGCATTCCTAAGAGACCATCTTCTCCTGTGATATCCAAGACAGCTACTAAAGCT
TATCCACAGTCTCCAAAGACAACGAAACCTCCCTACCCAGGGTCTCCTGTGAAGTACCGCTTACCTGCCCTTTCTGGCCAAGACATGCCC
AAGAGGAAAGCGGAGAAAGAGAAGAGCAACAAGGAAAGGGAAGGTACCTTGGCTCAGCAGGCTGCTGGCCCGCAAGGAGAGGAAGCCCTA
GAGAAGCATGTAGTGGACAAGCATGCCAGCGAGAAGCATGCTGCTGCCGCAGGAGGGAAAGCCGAAAACAGCGCAGCCTTGGGGAAGCCC
ACAGCAGGCACCACTGATGCAGGAGAGGCTGCGAAGATCTTGGCTGAAAAGAGAAGACAGGCCCGGCTGCAGAAGGAACAGGAGGAGCAA
GAACGACTGGAGAAGGAAGAACAAGATAGGCTGGAGAGAGAGGAATTGAAAAGAAAGGCAGAGGAGGAAAGGCTTCGCCTAGAAGAGGAA
GCCCGAAAGCAGGAAGAAGAAAGGAAGCGGCAGGAAGAGGAAAAGAAAAAACAGGAAGGGGAAGAGAAAAGAAAGGCAGGCGAGGAGGCC
AAGCGGAAGGCTGAGGAGGAGCTGTTGTTGAAAGAAAAGCAAGAACAAGAAAAACAAGAGAAAGCCATGATTGAAAAGCAGAAAGAAGCA
GCAGAAACAAAGGCCCGGGAGGTAGCTGAACAGATGCGTCTCGAGAGAGAACAGATTATGCTGCAGATTGAGCAGGAGAGACTGGAGAGA
AAGAAGAGAATAGATGAAATCATGAAGAGAACAAGGAAAAGTGATGTGTCTCCACAAGTGAAGAAAGAAGACCCCAAAGTGGGGGTCCAG
CCTGCTGTGTGTGTGGAAAAGAAGACAAAACTGGTTGTCCCCAACAAAATGGAAATCAATGGATTGAACACCTGCCAGGAAGTTAATGGT
GTGGATCACGCTGCCCCAGAAACTTATCCCCAAGACATTTTCTCTAATGGGCTTAAGCCAGCTGGGGGACTCATTCATCTGGATGCCCTT
GATGGGAAATCAAATAGCCTGGATGATTCAACTGAAGAAGTTCAGTCTATGGATGTGAGTCCTGTTTCAAAAGAAGAGCTTATCTCTATC
CCGGAATTTTCACCAGTGAGTGAAATGATTCCTGGGGTGTCTCTGGACCAAAATGGAACTGGTAATGCCCGAGCACTTCAAGATCTCTTA
GATTTCACTGGTCCCCCGACATTCCCCAAGAGATCCAGTGAAAATCTCAGCCTGGACGACTGTAACAAAAACCTTATCGAAGGATTTAAC
AGTCCTGGCCAAGAAACTCCTCTCAACACCTTCTGTTGACAAATACAGCATCCCTTTAATAAAAGGTGTTTGGAGAACCCGTAAAGCTGC
TGATAGTCAAATCCGAGCTACTAGCTGCTTGAAGAAGCTTCTGTCACCCTTACCGCTGGATCCCAAATTATTAGCTCGGAATGTAACTGT
ATTCCTAGGTAGTATGTCAAACACTGGCCACTCTTGGTAGAAACCTTGAAACTTTCACCTTGCTGGGCTTTAGCAAAGTTTCCTTTTACA
GTTCTGTTTATGAGCTTCAGCTACTGATAAAGCACTTCCTGAACTTCTCTATTATCATAGTGACCCTCTGAATAACCTGAGTGACTGGCT
CGGCAATTCGCTTTATAACCATTCTTATTCCCAAAGTTGGAGCACATAAACATTTAGATGTCTTTTCCTGTAAAATATTCTAGACATTTA
CCCAAACTCTAGTTCAACATATACTCAACTTGCACTGTATATCTCCCTGTCTTTTTTGAGACAGAGAAGAAATTCAGGAGGTTCCCCATC
TCCAGAGTTTCTCTGTTGGAAAGCAGTATCAAGAAGCCTTTAAAAAATTGTTGTTAAGCTTTGCCACCTGCAGAAATGCATTGCCCCACA
TTATTCTTCTGGGGTTAAAGTAGTAAGTTTGGTTGAGGAAGGAAGTCAAAACAGTCAGTAATGATTTCTGTTCTCTTATGCATATTCGTG
TATACATGGGCAACTGAATCTAGCAAGGACTCTTTCGTGTCACACCTTAAAATCTTCATGCTGTAGTCACTCCAGACCATGGAGTGGCTT
TCCAGCTGAATGAATCCTATGTCTCGCGTGCAGGTGGTTGGTTTTCAATGTTCTTGCTAATTTTTTTTCTATTGGATCTTGGGAGTTTTC
TTTGTTTGCTCCTGTGTTTGCCCAGCTTTAATAAAACCAGGCGCAAACAAAAACCATAGCATTCTGAAACAATAGGGGGCCCACATTGGA
CCCAGTATGTCACTTTAATGGACTTCAAGAAAAAATCTGAATGGGAAAAATGACACTAGAATGTATACTCCACACATTTTATGCCATATA
ATGGTGTGTTTTCTTAATTTTGTTTCTTGTGGCGAAATGTGGCTTTCAAATTAAAATGACCTTTTCTTCTTTGAAACTTTTTGTTTTGAC
TTGTATAATTAAGGGTTTGGAAAGATTCATAATTCTGAGAGAGGTTTGCAACCAGGAGATACAAAGAAGTCTCAGTAGTAATCTTGTTCA
TGTGCTTTTACAGCCAGCTACATTTAAGAATGTATTAGTTACAGAAATTATATGTCTGTGTATGTGTCTCTACTCAATAAAGTACATGCC
TCCACATAATGCGGTGCTGTCCATCTCGGCAAATACTGGCCAAGTCCCTTTATGACAGGCACACAGAAACCATAGCATGGTCTGGCTTTC
AGAAAATGCCTCTCATCTTTCCTGGAACCTTATTTTGCTAAATGTCTGTTTTCTTGTGATTTGTTGTACCTCACAGCACCATTGTGACCA

>78008_78008_5_RPS6KA3-MAP7D2_RPS6KA3_chrX_20284681_ENST00000379565_MAP7D2_chrX_20082923_ENST00000379643_length(amino acids)=729AA_BP=0
MEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRS
LERTQQLELKKKYSWGAPLAIGPGGHDACDKLSTSTMSLPKPTEPPMNKRLSSSTVAISYSPDRAHHMHLSPMEAILVSRLLTPTQSSLA
RSRASVMLSGQANDSVFHVCPRLAPLGPLNPSYKSSPTRNIEKKKATSTSTSGAGDVGKEALSGGEASLVEKVKRGQRTATSLPVVNFGS
PLRRCEFSGGIPKRPSSPVISKTATKAYPQSPKTTKPPYPGSPVKYRLPALSGQDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKH
VVDKHASEKHAAAAGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERLEKEEQDRLEREELKRKAEEERLRLEEEARK
QEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKR
IDEIMKRTRKSDVSPQVKKEDPKVGVQPAVCVEKKTKLVVPNKMEINGLNTCQEVNGVDHAAPETYPQDIFSNGLKPAGGLIHLDALDGK
SNSLDDSTEEVQSMDVSPVSKEELISIPEFSPVSEMIPGVSLDQNGTGNARALQDLLDFTGPPTFPKRSSENLSLDDCNKNLIEGFNSPG

--------------------------------------------------------------
>78008_78008_6_RPS6KA3-MAP7D2_RPS6KA3_chrX_20284681_ENST00000379565_MAP7D2_chrX_20082923_ENST00000379651_length(transcript)=4058nt_BP=277nt
AGGCGCGCGGCTTTCGGGCGGTCGGCGTCGGCGTCGAGCCCTCTCTGGGGCCGCCGCCGCTGCTGCTGCTGCTGCCGCTGCCGCTGCCGC
TGCCGCCGCCGCCGCCGCCGCCGCCGCTGCCGTGGGGCTCGGGCGGCGACGGAGCGGGGCCGGCCGTGGGGCGGGCGGGGAGGGAGGAGG
CGGTGAAGGCGGCGGGCCGGGGGGGAAGATGCCGCTGGCGCAGCTGGCGGACCCGTGGCAGAAGATGGCTGTGGAGAGCCCGTCCGACAG
CGCTGAGGCATGGAGGGATTTTTGAAATCAGATGAGAGGCAGAGATTGGCCAAAGAAAGACGAGAAGAAAGAGAAAAATGTCTGGCTGCT
CGGGAGCAACAGATCCTGGAGAAACAGAAAAGAGCCAGGCTGCAGTACGAAAAGCAAATGGAGGAGCGATGGCGAAAACTGGAAGAGCAG
CGGCAGCGGGAGGACCAAAAGAGAGCTGCTGTGGAAGAGAAAAGGAAACAGAAGCTCCGGGAGGAGGAGGAACGGCTGGAGGCGATGATG
CGCCGGTCCCTGGAGCGCACACAGCAGCTGGAGCTGAAAAAGAAGTATTCGTGGGGAGCACCACTGGCCATTGGACCCGGAGGACATGAT
GCATGTGACAAACTTTCAACATCAACTATGAGTTTGCCAAAGCCAACGGAGCCTCCCATGAATAAACGCCTGTCTTCATCCACCGTGGCA
ATATCCTATTCCCCAGACCGAGTATTCCATGTCTGTCCTCGTTTAGCTCCTCTTGGCCCTCTTAACCCTTCTTACAAGTCTTCACCCACT
CGAAACATTGAGAAGAAGAAAGCTACATCTACGTCTACATCTGGTGCAGGAGATGTTGGGAAAGAAGCCCTTTCAGGAGGAGAGGCCTCT
CTGGTGGAGAAGGTGAAGCGGGGGCAACGAACAGCAACTTCTCTTCCTGTTGTGAACTTCGGGTCCCCTCTGAGAAGATGTGAGTTTTCT
GGAGGCATTCCTAAGAGACCATCTTCTCCTGTGATATCCAAGACAGCTACTAAAGCTTATCCACAGTCTCCAAAGACAACGAAACCTCCC
TACCCAGGGTCTCCTGTGAAGTACCGCTTACCTGCCCTTTCTGGCCAAGACATGCCCAAGAGGAAAGCGGAGAAAGAGAAGAGCAACAAG
GAAAGGGAAGGTACCTTGGCTCAGCAGGCTGCTGGCCCGCAAGGAGAGGAAGCCCTAGAGAAGCATGTAGTGGACAAGCATGCCAGCGAG
AAGCATGCTGCTGCCGCAGGAGGGAAAGCCGAAAACAGCGCAGCCTTGGGGAAGCCCACAGCAGGCACCACTGATGCAGGAGAGGCTGCG
AAGATCTTGGCTGAAAAGAGAAGACAGGCCCGGCTGCAGAAGGAACAGGAGGAGCAAGAACGACTGGAGAAGGAAGAACAAGATAGGCTG
GAGAGAGAGGAATTGAAAAGAAAGGCAGAGGAGGAAAGGCTTCGCCTAGAAGAGGAAGCCCGAAAGCAGGAAGAAGAAAGGAAGCGGCAG
GAAGAGGAAAAGAAAAAACAGGAAGGGGAAGAGAAAAGAAAGGCAGGCGAGGAGGCCAAGCGGAAGGCTGAGGAGGAGCTGTTGTTGAAA
GAAAAGCAAGAACAAGAAAAACAAGAGAAAGCCATGATTGAAAAGCAGAAAGAAGCAGCAGAAACAAAGGCCCGGGAGGTAGCTGAACAG
ATGCGTCTCGAGAGAGAACAGATTATGCTGCAGATTGAGCAGGAGAGACTGGAGAGAAAGAAGAGAATAGATGAAATCATGAAGAGAACA
AGGAAAAGTGATGTGTCTCCACAAGTGAAGAAAGAAGACCCCAAAGTGGGGGTCCAGCCTGCTGTGTGTGTGGAAAAGAAGACAAAACTG
GTTGTCCCCAACAAAATGGAAATCAATGGATTGAACACCTGCCAGGAAGTTAATGGTGTGGATCACGCTGCCCCAGAAACTTATCCCCAA
GACATTTTCTCTAATGGGCTTAAGCCAGCTGGGGGACTCATTCATCTGGATGCCCTTGATGGGAAATCAAATAGCCTGGATGATTCAACT
GAAGAAGTTCAGTCTATGGATGTGAGTCCTGTTTCAAAAGAAGAGCTTATCTCTATCCCGGAATTTTCACCAGTGAGTGAAATGATTCCT
GGGGTGTCTCTGGACCAAAATGGAACTGGTAATGCCCGAGCACTTCAAGATCTCTTAGATTTCACTGGTCCCCCGACATTCCCCAAGAGA
TCCAGTGAAAATCTCAGCCTGGACGACTGTAACAAAAACCTTATCGAAGGATTTAACAGTCCTGGCCAAGAAACTCCTCTCAACACCTTC
TGTTGACAAATACAGCATCCCTTTAATAAAAGGTGTTTGGAGAACCCGTAAAGCTGCTGATAGTCAAATCCGAGCTACTAGCTGCTTGAA
GAAGCTTCTGTCACCCTTACCGCTGGATCCCAAATTATTAGCTCGGAATGTAACTGTATTCCTAGGTAGTATGTCAAACACTGGCCACTC
TTGGTAGAAACCTTGAAACTTTCACCTTGCTGGGCTTTAGCAAAGTTTCCTTTTACAGTTCTGTTTATGAGCTTCAGCTACTGATAAAGC
ACTTCCTGAACTTCTCTATTATCATAGTGACCCTCTGAATAACCTGAGTGACTGGCTCGGCAATTCGCTTTATAACCATTCTTATTCCCA
AAGTTGGAGCACATAAACATTTAGATGTCTTTTCCTGTAAAATATTCTAGACATTTACCCAAACTCTAGTTCAACATATACTCAACTTGC
ACTGTATATCTCCCTGTCTTTTTTGAGACAGAGAAGAAATTCAGGAGGTTCCCCATCTCCAGAGTTTCTCTGTTGGAAAGCAGTATCAAG
AAGCCTTTAAAAAATTGTTGTTAAGCTTTGCCACCTGCAGAAATGCATTGCCCCACATTATTCTTCTGGGGTTAAAGTAGTAAGTTTGGT
TGAGGAAGGAAGTCAAAACAGTCAGTAATGATTTCTGTTCTCTTATGCATATTCGTGTATACATGGGCAACTGAATCTAGCAAGGACTCT
TTCGTGTCACACCTTAAAATCTTCATGCTGTAGTCACTCCAGACCATGGAGTGGCTTTCCAGCTGAATGAATCCTATGTCTCGCGTGCAG
GTGGTTGGTTTTCAATGTTCTTGCTAATTTTTTTTCTATTGGATCTTGGGAGTTTTCTTTGTTTGCTCCTGTGTTTGCCCAGCTTTAATA
AAACCAGGCGCAAACAAAAACCATAGCATTCTGAAACAATAGGGGGCCCACATTGGACCCAGTATGTCACTTTAATGGACTTCAAGAAAA
AATCTGAATGGGAAAAATGACACTAGAATGTATACTCCACACATTTTATGCCATATAATGGTGTGTTTTCTTAATTTTGTTTCTTGTGGC
GAAATGTGGCTTTCAAATTAAAATGACCTTTTCTTCTTTGAAACTTTTTGTTTTGACTTGTATAATTAAGGGTTTGGAAAGATTCATAAT
TCTGAGAGAGGTTTGCAACCAGGAGATACAAAGAAGTCTCAGTAGTAATCTTGTTCATGTGCTTTTACAGCCAGCTACATTTAAGAATGT
ATTAGTTACAGAAATTATATGTCTGTGTATGTGTCTCTACTCAATAAAGTACATGCCTCCACATAATGCGGTGCTGTCCATCTCGGCAAA
TACTGGCCAAGTCCCTTTATGACAGGCACACAGAAACCATAGCATGGTCTGGCTTTCAGAAAATGCCTCTCATCTTTCCTGGAACCTTAT
TTTGCTAAATGTCTGTTTTCTTGTGATTTGTTGTACCTCACAGCACCATTGTGACCATGGTGATGCCTCATTTGCATGATATGTACCTTG
TGTTTAATGTGAAATACATTTTCATTGAAGAGTCTGATGACTTGCTAGCGTTTTATTTTTTCTGTAAGCTCAATGTGCTGAAACCAAACC
AGGCTTTTAAAAACCTGTGTAGAAGAAAACCAAAAAATCCTGTGTGGGTGTCCTTTCCCTGTCAAACTCATTAAAAATTCCTTTGTTGCC

>78008_78008_6_RPS6KA3-MAP7D2_RPS6KA3_chrX_20284681_ENST00000379565_MAP7D2_chrX_20082923_ENST00000379651_length(amino acids)=688AA_BP=0
MEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRS
LERTQQLELKKKYSWGAPLAIGPGGHDACDKLSTSTMSLPKPTEPPMNKRLSSSTVAISYSPDRVFHVCPRLAPLGPLNPSYKSSPTRNI
EKKKATSTSTSGAGDVGKEALSGGEASLVEKVKRGQRTATSLPVVNFGSPLRRCEFSGGIPKRPSSPVISKTATKAYPQSPKTTKPPYPG
SPVKYRLPALSGQDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPTAGTTDAGEAAKIL
AEKRRQARLQKEQEEQERLEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQ
EQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVSPQVKKEDPKVGVQPAVCVEKKTKLVVP
NKMEINGLNTCQEVNGVDHAAPETYPQDIFSNGLKPAGGLIHLDALDGKSNSLDDSTEEVQSMDVSPVSKEELISIPEFSPVSEMIPGVS

--------------------------------------------------------------
>78008_78008_7_RPS6KA3-MAP7D2_RPS6KA3_chrX_20284682_ENST00000379565_MAP7D2_chrX_20082923_ENST00000379643_length(transcript)=4027nt_BP=277nt
AGGCGCGCGGCTTTCGGGCGGTCGGCGTCGGCGTCGAGCCCTCTCTGGGGCCGCCGCCGCTGCTGCTGCTGCTGCCGCTGCCGCTGCCGC
TGCCGCCGCCGCCGCCGCCGCCGCCGCTGCCGTGGGGCTCGGGCGGCGACGGAGCGGGGCCGGCCGTGGGGCGGGCGGGGAGGGAGGAGG
CGGTGAAGGCGGCGGGCCGGGGGGGAAGATGCCGCTGGCGCAGCTGGCGGACCCGTGGCAGAAGATGGCTGTGGAGAGCCCGTCCGACAG
CGCTGAGGCATGGAGGGATTTTTGAAATCAGATGAGAGGCAGAGATTGGCCAAAGAAAGACGAGAAGAAAGAGAAAAATGTCTGGCTGCT
CGGGAGCAACAGATCCTGGAGAAACAGAAAAGAGCCAGGCTGCAGTACGAAAAGCAAATGGAGGAGCGATGGCGAAAACTGGAAGAGCAG
CGGCAGCGGGAGGACCAAAAGAGAGCTGCTGTGGAAGAGAAAAGGAAACAGAAGCTCCGGGAGGAGGAGGAACGGCTGGAGGCGATGATG
CGCCGGTCCCTGGAGCGCACACAGCAGCTGGAGCTGAAAAAGAAGTATTCGTGGGGAGCACCACTGGCCATTGGACCCGGAGGACATGAT
GCATGTGACAAACTTTCAACATCAACTATGAGTTTGCCAAAGCCAACGGAGCCTCCCATGAATAAACGCCTGTCTTCATCCACCGTGGCA
ATATCCTATTCCCCAGACCGAGCTCATCACATGCACCTTAGTCCAATGGAAGCCATTCTTGTTTCGCGACTGTTGACACCCACACAGTCT
TCTTTAGCCAGAAGCAGAGCTTCAGTCATGCTCTCTGGGCAGGCCAATGATTCAGTATTCCATGTCTGTCCTCGTTTAGCTCCTCTTGGC
CCTCTTAACCCTTCTTACAAGTCTTCACCCACTCGAAACATTGAGAAGAAGAAAGCTACATCTACGTCTACATCTGGTGCAGGAGATGTT
GGGAAAGAAGCCCTTTCAGGAGGAGAGGCCTCTCTGGTGGAGAAGGTGAAGCGGGGGCAACGAACAGCAACTTCTCTTCCTGTTGTGAAC
TTCGGGTCCCCTCTGAGAAGATGTGAGTTTTCTGGAGGCATTCCTAAGAGACCATCTTCTCCTGTGATATCCAAGACAGCTACTAAAGCT
TATCCACAGTCTCCAAAGACAACGAAACCTCCCTACCCAGGGTCTCCTGTGAAGTACCGCTTACCTGCCCTTTCTGGCCAAGACATGCCC
AAGAGGAAAGCGGAGAAAGAGAAGAGCAACAAGGAAAGGGAAGGTACCTTGGCTCAGCAGGCTGCTGGCCCGCAAGGAGAGGAAGCCCTA
GAGAAGCATGTAGTGGACAAGCATGCCAGCGAGAAGCATGCTGCTGCCGCAGGAGGGAAAGCCGAAAACAGCGCAGCCTTGGGGAAGCCC
ACAGCAGGCACCACTGATGCAGGAGAGGCTGCGAAGATCTTGGCTGAAAAGAGAAGACAGGCCCGGCTGCAGAAGGAACAGGAGGAGCAA
GAACGACTGGAGAAGGAAGAACAAGATAGGCTGGAGAGAGAGGAATTGAAAAGAAAGGCAGAGGAGGAAAGGCTTCGCCTAGAAGAGGAA
GCCCGAAAGCAGGAAGAAGAAAGGAAGCGGCAGGAAGAGGAAAAGAAAAAACAGGAAGGGGAAGAGAAAAGAAAGGCAGGCGAGGAGGCC
AAGCGGAAGGCTGAGGAGGAGCTGTTGTTGAAAGAAAAGCAAGAACAAGAAAAACAAGAGAAAGCCATGATTGAAAAGCAGAAAGAAGCA
GCAGAAACAAAGGCCCGGGAGGTAGCTGAACAGATGCGTCTCGAGAGAGAACAGATTATGCTGCAGATTGAGCAGGAGAGACTGGAGAGA
AAGAAGAGAATAGATGAAATCATGAAGAGAACAAGGAAAAGTGATGTGTCTCCACAAGTGAAGAAAGAAGACCCCAAAGTGGGGGTCCAG
CCTGCTGTGTGTGTGGAAAAGAAGACAAAACTGGTTGTCCCCAACAAAATGGAAATCAATGGATTGAACACCTGCCAGGAAGTTAATGGT
GTGGATCACGCTGCCCCAGAAACTTATCCCCAAGACATTTTCTCTAATGGGCTTAAGCCAGCTGGGGGACTCATTCATCTGGATGCCCTT
GATGGGAAATCAAATAGCCTGGATGATTCAACTGAAGAAGTTCAGTCTATGGATGTGAGTCCTGTTTCAAAAGAAGAGCTTATCTCTATC
CCGGAATTTTCACCAGTGAGTGAAATGATTCCTGGGGTGTCTCTGGACCAAAATGGAACTGGTAATGCCCGAGCACTTCAAGATCTCTTA
GATTTCACTGGTCCCCCGACATTCCCCAAGAGATCCAGTGAAAATCTCAGCCTGGACGACTGTAACAAAAACCTTATCGAAGGATTTAAC
AGTCCTGGCCAAGAAACTCCTCTCAACACCTTCTGTTGACAAATACAGCATCCCTTTAATAAAAGGTGTTTGGAGAACCCGTAAAGCTGC
TGATAGTCAAATCCGAGCTACTAGCTGCTTGAAGAAGCTTCTGTCACCCTTACCGCTGGATCCCAAATTATTAGCTCGGAATGTAACTGT
ATTCCTAGGTAGTATGTCAAACACTGGCCACTCTTGGTAGAAACCTTGAAACTTTCACCTTGCTGGGCTTTAGCAAAGTTTCCTTTTACA
GTTCTGTTTATGAGCTTCAGCTACTGATAAAGCACTTCCTGAACTTCTCTATTATCATAGTGACCCTCTGAATAACCTGAGTGACTGGCT
CGGCAATTCGCTTTATAACCATTCTTATTCCCAAAGTTGGAGCACATAAACATTTAGATGTCTTTTCCTGTAAAATATTCTAGACATTTA
CCCAAACTCTAGTTCAACATATACTCAACTTGCACTGTATATCTCCCTGTCTTTTTTGAGACAGAGAAGAAATTCAGGAGGTTCCCCATC
TCCAGAGTTTCTCTGTTGGAAAGCAGTATCAAGAAGCCTTTAAAAAATTGTTGTTAAGCTTTGCCACCTGCAGAAATGCATTGCCCCACA
TTATTCTTCTGGGGTTAAAGTAGTAAGTTTGGTTGAGGAAGGAAGTCAAAACAGTCAGTAATGATTTCTGTTCTCTTATGCATATTCGTG
TATACATGGGCAACTGAATCTAGCAAGGACTCTTTCGTGTCACACCTTAAAATCTTCATGCTGTAGTCACTCCAGACCATGGAGTGGCTT
TCCAGCTGAATGAATCCTATGTCTCGCGTGCAGGTGGTTGGTTTTCAATGTTCTTGCTAATTTTTTTTCTATTGGATCTTGGGAGTTTTC
TTTGTTTGCTCCTGTGTTTGCCCAGCTTTAATAAAACCAGGCGCAAACAAAAACCATAGCATTCTGAAACAATAGGGGGCCCACATTGGA
CCCAGTATGTCACTTTAATGGACTTCAAGAAAAAATCTGAATGGGAAAAATGACACTAGAATGTATACTCCACACATTTTATGCCATATA
ATGGTGTGTTTTCTTAATTTTGTTTCTTGTGGCGAAATGTGGCTTTCAAATTAAAATGACCTTTTCTTCTTTGAAACTTTTTGTTTTGAC
TTGTATAATTAAGGGTTTGGAAAGATTCATAATTCTGAGAGAGGTTTGCAACCAGGAGATACAAAGAAGTCTCAGTAGTAATCTTGTTCA
TGTGCTTTTACAGCCAGCTACATTTAAGAATGTATTAGTTACAGAAATTATATGTCTGTGTATGTGTCTCTACTCAATAAAGTACATGCC
TCCACATAATGCGGTGCTGTCCATCTCGGCAAATACTGGCCAAGTCCCTTTATGACAGGCACACAGAAACCATAGCATGGTCTGGCTTTC
AGAAAATGCCTCTCATCTTTCCTGGAACCTTATTTTGCTAAATGTCTGTTTTCTTGTGATTTGTTGTACCTCACAGCACCATTGTGACCA

>78008_78008_7_RPS6KA3-MAP7D2_RPS6KA3_chrX_20284682_ENST00000379565_MAP7D2_chrX_20082923_ENST00000379643_length(amino acids)=729AA_BP=0
MEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRS
LERTQQLELKKKYSWGAPLAIGPGGHDACDKLSTSTMSLPKPTEPPMNKRLSSSTVAISYSPDRAHHMHLSPMEAILVSRLLTPTQSSLA
RSRASVMLSGQANDSVFHVCPRLAPLGPLNPSYKSSPTRNIEKKKATSTSTSGAGDVGKEALSGGEASLVEKVKRGQRTATSLPVVNFGS
PLRRCEFSGGIPKRPSSPVISKTATKAYPQSPKTTKPPYPGSPVKYRLPALSGQDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKH
VVDKHASEKHAAAAGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERLEKEEQDRLEREELKRKAEEERLRLEEEARK
QEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKR
IDEIMKRTRKSDVSPQVKKEDPKVGVQPAVCVEKKTKLVVPNKMEINGLNTCQEVNGVDHAAPETYPQDIFSNGLKPAGGLIHLDALDGK
SNSLDDSTEEVQSMDVSPVSKEELISIPEFSPVSEMIPGVSLDQNGTGNARALQDLLDFTGPPTFPKRSSENLSLDDCNKNLIEGFNSPG

--------------------------------------------------------------
>78008_78008_8_RPS6KA3-MAP7D2_RPS6KA3_chrX_20284682_ENST00000379565_MAP7D2_chrX_20082923_ENST00000379651_length(transcript)=4058nt_BP=277nt
AGGCGCGCGGCTTTCGGGCGGTCGGCGTCGGCGTCGAGCCCTCTCTGGGGCCGCCGCCGCTGCTGCTGCTGCTGCCGCTGCCGCTGCCGC
TGCCGCCGCCGCCGCCGCCGCCGCCGCTGCCGTGGGGCTCGGGCGGCGACGGAGCGGGGCCGGCCGTGGGGCGGGCGGGGAGGGAGGAGG
CGGTGAAGGCGGCGGGCCGGGGGGGAAGATGCCGCTGGCGCAGCTGGCGGACCCGTGGCAGAAGATGGCTGTGGAGAGCCCGTCCGACAG
CGCTGAGGCATGGAGGGATTTTTGAAATCAGATGAGAGGCAGAGATTGGCCAAAGAAAGACGAGAAGAAAGAGAAAAATGTCTGGCTGCT
CGGGAGCAACAGATCCTGGAGAAACAGAAAAGAGCCAGGCTGCAGTACGAAAAGCAAATGGAGGAGCGATGGCGAAAACTGGAAGAGCAG
CGGCAGCGGGAGGACCAAAAGAGAGCTGCTGTGGAAGAGAAAAGGAAACAGAAGCTCCGGGAGGAGGAGGAACGGCTGGAGGCGATGATG
CGCCGGTCCCTGGAGCGCACACAGCAGCTGGAGCTGAAAAAGAAGTATTCGTGGGGAGCACCACTGGCCATTGGACCCGGAGGACATGAT
GCATGTGACAAACTTTCAACATCAACTATGAGTTTGCCAAAGCCAACGGAGCCTCCCATGAATAAACGCCTGTCTTCATCCACCGTGGCA
ATATCCTATTCCCCAGACCGAGTATTCCATGTCTGTCCTCGTTTAGCTCCTCTTGGCCCTCTTAACCCTTCTTACAAGTCTTCACCCACT
CGAAACATTGAGAAGAAGAAAGCTACATCTACGTCTACATCTGGTGCAGGAGATGTTGGGAAAGAAGCCCTTTCAGGAGGAGAGGCCTCT
CTGGTGGAGAAGGTGAAGCGGGGGCAACGAACAGCAACTTCTCTTCCTGTTGTGAACTTCGGGTCCCCTCTGAGAAGATGTGAGTTTTCT
GGAGGCATTCCTAAGAGACCATCTTCTCCTGTGATATCCAAGACAGCTACTAAAGCTTATCCACAGTCTCCAAAGACAACGAAACCTCCC
TACCCAGGGTCTCCTGTGAAGTACCGCTTACCTGCCCTTTCTGGCCAAGACATGCCCAAGAGGAAAGCGGAGAAAGAGAAGAGCAACAAG
GAAAGGGAAGGTACCTTGGCTCAGCAGGCTGCTGGCCCGCAAGGAGAGGAAGCCCTAGAGAAGCATGTAGTGGACAAGCATGCCAGCGAG
AAGCATGCTGCTGCCGCAGGAGGGAAAGCCGAAAACAGCGCAGCCTTGGGGAAGCCCACAGCAGGCACCACTGATGCAGGAGAGGCTGCG
AAGATCTTGGCTGAAAAGAGAAGACAGGCCCGGCTGCAGAAGGAACAGGAGGAGCAAGAACGACTGGAGAAGGAAGAACAAGATAGGCTG
GAGAGAGAGGAATTGAAAAGAAAGGCAGAGGAGGAAAGGCTTCGCCTAGAAGAGGAAGCCCGAAAGCAGGAAGAAGAAAGGAAGCGGCAG
GAAGAGGAAAAGAAAAAACAGGAAGGGGAAGAGAAAAGAAAGGCAGGCGAGGAGGCCAAGCGGAAGGCTGAGGAGGAGCTGTTGTTGAAA
GAAAAGCAAGAACAAGAAAAACAAGAGAAAGCCATGATTGAAAAGCAGAAAGAAGCAGCAGAAACAAAGGCCCGGGAGGTAGCTGAACAG
ATGCGTCTCGAGAGAGAACAGATTATGCTGCAGATTGAGCAGGAGAGACTGGAGAGAAAGAAGAGAATAGATGAAATCATGAAGAGAACA
AGGAAAAGTGATGTGTCTCCACAAGTGAAGAAAGAAGACCCCAAAGTGGGGGTCCAGCCTGCTGTGTGTGTGGAAAAGAAGACAAAACTG
GTTGTCCCCAACAAAATGGAAATCAATGGATTGAACACCTGCCAGGAAGTTAATGGTGTGGATCACGCTGCCCCAGAAACTTATCCCCAA
GACATTTTCTCTAATGGGCTTAAGCCAGCTGGGGGACTCATTCATCTGGATGCCCTTGATGGGAAATCAAATAGCCTGGATGATTCAACT
GAAGAAGTTCAGTCTATGGATGTGAGTCCTGTTTCAAAAGAAGAGCTTATCTCTATCCCGGAATTTTCACCAGTGAGTGAAATGATTCCT
GGGGTGTCTCTGGACCAAAATGGAACTGGTAATGCCCGAGCACTTCAAGATCTCTTAGATTTCACTGGTCCCCCGACATTCCCCAAGAGA
TCCAGTGAAAATCTCAGCCTGGACGACTGTAACAAAAACCTTATCGAAGGATTTAACAGTCCTGGCCAAGAAACTCCTCTCAACACCTTC
TGTTGACAAATACAGCATCCCTTTAATAAAAGGTGTTTGGAGAACCCGTAAAGCTGCTGATAGTCAAATCCGAGCTACTAGCTGCTTGAA
GAAGCTTCTGTCACCCTTACCGCTGGATCCCAAATTATTAGCTCGGAATGTAACTGTATTCCTAGGTAGTATGTCAAACACTGGCCACTC
TTGGTAGAAACCTTGAAACTTTCACCTTGCTGGGCTTTAGCAAAGTTTCCTTTTACAGTTCTGTTTATGAGCTTCAGCTACTGATAAAGC
ACTTCCTGAACTTCTCTATTATCATAGTGACCCTCTGAATAACCTGAGTGACTGGCTCGGCAATTCGCTTTATAACCATTCTTATTCCCA
AAGTTGGAGCACATAAACATTTAGATGTCTTTTCCTGTAAAATATTCTAGACATTTACCCAAACTCTAGTTCAACATATACTCAACTTGC
ACTGTATATCTCCCTGTCTTTTTTGAGACAGAGAAGAAATTCAGGAGGTTCCCCATCTCCAGAGTTTCTCTGTTGGAAAGCAGTATCAAG
AAGCCTTTAAAAAATTGTTGTTAAGCTTTGCCACCTGCAGAAATGCATTGCCCCACATTATTCTTCTGGGGTTAAAGTAGTAAGTTTGGT
TGAGGAAGGAAGTCAAAACAGTCAGTAATGATTTCTGTTCTCTTATGCATATTCGTGTATACATGGGCAACTGAATCTAGCAAGGACTCT
TTCGTGTCACACCTTAAAATCTTCATGCTGTAGTCACTCCAGACCATGGAGTGGCTTTCCAGCTGAATGAATCCTATGTCTCGCGTGCAG
GTGGTTGGTTTTCAATGTTCTTGCTAATTTTTTTTCTATTGGATCTTGGGAGTTTTCTTTGTTTGCTCCTGTGTTTGCCCAGCTTTAATA
AAACCAGGCGCAAACAAAAACCATAGCATTCTGAAACAATAGGGGGCCCACATTGGACCCAGTATGTCACTTTAATGGACTTCAAGAAAA
AATCTGAATGGGAAAAATGACACTAGAATGTATACTCCACACATTTTATGCCATATAATGGTGTGTTTTCTTAATTTTGTTTCTTGTGGC
GAAATGTGGCTTTCAAATTAAAATGACCTTTTCTTCTTTGAAACTTTTTGTTTTGACTTGTATAATTAAGGGTTTGGAAAGATTCATAAT
TCTGAGAGAGGTTTGCAACCAGGAGATACAAAGAAGTCTCAGTAGTAATCTTGTTCATGTGCTTTTACAGCCAGCTACATTTAAGAATGT
ATTAGTTACAGAAATTATATGTCTGTGTATGTGTCTCTACTCAATAAAGTACATGCCTCCACATAATGCGGTGCTGTCCATCTCGGCAAA
TACTGGCCAAGTCCCTTTATGACAGGCACACAGAAACCATAGCATGGTCTGGCTTTCAGAAAATGCCTCTCATCTTTCCTGGAACCTTAT
TTTGCTAAATGTCTGTTTTCTTGTGATTTGTTGTACCTCACAGCACCATTGTGACCATGGTGATGCCTCATTTGCATGATATGTACCTTG
TGTTTAATGTGAAATACATTTTCATTGAAGAGTCTGATGACTTGCTAGCGTTTTATTTTTTCTGTAAGCTCAATGTGCTGAAACCAAACC
AGGCTTTTAAAAACCTGTGTAGAAGAAAACCAAAAAATCCTGTGTGGGTGTCCTTTCCCTGTCAAACTCATTAAAAATTCCTTTGTTGCC

>78008_78008_8_RPS6KA3-MAP7D2_RPS6KA3_chrX_20284682_ENST00000379565_MAP7D2_chrX_20082923_ENST00000379651_length(amino acids)=688AA_BP=0
MEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRS
LERTQQLELKKKYSWGAPLAIGPGGHDACDKLSTSTMSLPKPTEPPMNKRLSSSTVAISYSPDRVFHVCPRLAPLGPLNPSYKSSPTRNI
EKKKATSTSTSGAGDVGKEALSGGEASLVEKVKRGQRTATSLPVVNFGSPLRRCEFSGGIPKRPSSPVISKTATKAYPQSPKTTKPPYPG
SPVKYRLPALSGQDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPTAGTTDAGEAAKIL
AEKRRQARLQKEQEEQERLEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQ
EQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVSPQVKKEDPKVGVQPAVCVEKKTKLVVP
NKMEINGLNTCQEVNGVDHAAPETYPQDIFSNGLKPAGGLIHLDALDGKSNSLDDSTEEVQSMDVSPVSKEELISIPEFSPVSEMIPGVS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RPS6KA3-MAP7D2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RPS6KA3-MAP7D2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RPS6KA3-MAP7D2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource