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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:RPS6KA3-NUP50 (FusionGDB2 ID:78009)

Fusion Gene Summary for RPS6KA3-NUP50

Fusion gene summary

Fusion gene information	Fusion gene name: RPS6KA3-NUP50
	Fusion gene ID: 78009
		Hgene	Tgene
	Gene symbol	RPS6KA3	NUP50
	Gene ID	6197	10762
	Gene name	ribosomal protein S6 kinase A3	nucleoporin 50
	Synonyms	CLS\|HU-3\|ISPK-1\|MAPKAPK1B\|MRX19\|RSK\|RSK2\|S6K-alpha3\|p90-RSK2\|pp90RSK2	NPAP60\|NPAP60L
	Cytomap	Xp22.12	22q13.31
	Type of gene	protein-coding	protein-coding
	Description	ribosomal protein S6 kinase alpha-3MAP kinase-activated protein kinase 1bMAPK-activated protein kinase 1bMAPKAP kinase 1bMAPKAPK-1bRSK-2S6K-alpha-3epididymis secretory sperm binding proteininsulin-stimulated protein kinase 1p90-RSK 3ribosomal S6	nuclear pore complex protein Nup5050 kDa nucleoporinnuclear pore-associated protein 60Lnucleoporin 50kDnucleoporin 50kDanucleoporin Nup50
	Modification date	20200327	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000379548, ENST00000379565, ENST00000540702, ENST00000544447, ENST00000479809,	ENST00000486184, ENST00000396096, ENST00000407019, ENST00000425733, ENST00000347635,
Fusion gene scores	* DoF score	15 X 11 X 7=1155	2 X 2 X 2=8
	# samples	19	2
	** MAII score	log2(19/1155*10)=-2.60382152797247 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: RPS6KA3 [Title/Abstract] AND NUP50 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RPS6KA3(20187519)-NUP50(45567480), # samples:1
Anticipated loss of major functional domain due to fusion event.	RPS6KA3-NUP50 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. RPS6KA3-NUP50 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. RPS6KA3-NUP50 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. RPS6KA3-NUP50 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPS6KA3	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	18402937

Fusion gene breakpoints across RPS6KA3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NUP50 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-IG-A97I	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+

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Fusion Gene ORF analysis for RPS6KA3-NUP50

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000379548	ENST00000486184	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+
5CDS-3UTR	ENST00000379565	ENST00000486184	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+
5CDS-3UTR	ENST00000540702	ENST00000486184	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+
5CDS-3UTR	ENST00000544447	ENST00000486184	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+
5CDS-5UTR	ENST00000379548	ENST00000396096	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+
5CDS-5UTR	ENST00000379548	ENST00000407019	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+
5CDS-5UTR	ENST00000379548	ENST00000425733	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+
5CDS-5UTR	ENST00000379565	ENST00000396096	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+
5CDS-5UTR	ENST00000379565	ENST00000407019	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+
5CDS-5UTR	ENST00000379565	ENST00000425733	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+
5CDS-5UTR	ENST00000540702	ENST00000396096	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+
5CDS-5UTR	ENST00000540702	ENST00000407019	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+
5CDS-5UTR	ENST00000540702	ENST00000425733	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+
5CDS-5UTR	ENST00000544447	ENST00000396096	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+
5CDS-5UTR	ENST00000544447	ENST00000407019	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+
5CDS-5UTR	ENST00000544447	ENST00000425733	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+
5UTR-3CDS	ENST00000479809	ENST00000347635	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+
5UTR-3UTR	ENST00000479809	ENST00000486184	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+
5UTR-5UTR	ENST00000479809	ENST00000396096	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+
5UTR-5UTR	ENST00000479809	ENST00000407019	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+
5UTR-5UTR	ENST00000479809	ENST00000425733	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+
Frame-shift	ENST00000544447	ENST00000347635	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+
In-frame	ENST00000379548	ENST00000347635	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+
In-frame	ENST00000379565	ENST00000347635	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+
In-frame	ENST00000540702	ENST00000347635	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000379565	RPS6KA3	chrX	20187519	-	ENST00000347635	NUP50	chr22	45567480	+	6349	1651	208	2988	926
ENST00000379548	RPS6KA3	chrX	20187519	-	ENST00000347635	NUP50	chr22	45567480	+	6074	1376	23	2713	896
ENST00000540702	RPS6KA3	chrX	20187519	-	ENST00000347635	NUP50	chr22	45567480	+	6202	1504	109	2841	910

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000379565	ENST00000347635	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+	6.88E-05	0.9999312
ENST00000379548	ENST00000347635	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+	7.35E-05	0.99992645
ENST00000540702	ENST00000347635	RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+	0.000114916	0.9998851

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Fusion Genomic Features for RPS6KA3-NUP50

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+	0.10278761	0.89721245
RPS6KA3	chrX	20187519	-	NUP50	chr22	45567480	+	0.10278761	0.89721245

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RPS6KA3-NUP50

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:20187519/chr22:45567480)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RPS6KA3

chrX:20187519

chr22:45567480

ENST00000379565

328_397

481

741.0

Domain

AGC-kinase C-terminal

Hgene

RPS6KA3

chrX:20187519

chr22:45567480

ENST00000379565

68_327

481

741.0

Domain

Protein kinase 1

Hgene

RPS6KA3

chrX:20187519

chr22:45567480

ENST00000379565

428_436

481

741.0

Nucleotide binding

ATP

Hgene

RPS6KA3

chrX:20187519

chr22:45567480

ENST00000379565

74_82

481

741.0

Nucleotide binding

ATP

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000347635

268_330

469.0

Compositional bias

Note=Ser-rich

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000347635

55_91

469.0

Compositional bias

Note=Gly-rich

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000396096

268_330

441.0

Compositional bias

Note=Ser-rich

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000396096

55_91

441.0

Compositional bias

Note=Gly-rich

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000407019

268_330

441.0

Compositional bias

Note=Ser-rich

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000407019

55_91

441.0

Compositional bias

Note=Gly-rich

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000347635

335_468

469.0

Domain

RanBD1

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000396096

335_468

441.0

Domain

RanBD1

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000407019

335_468

441.0

Domain

RanBD1

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000347635

144_206

469.0

Region

Binding to CDKN1B

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000347635

76_304

469.0

Region

Note=5 X 2 AA repeats of F-G

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000396096

144_206

441.0

Region

Binding to CDKN1B

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000396096

76_304

441.0

Region

Note=5 X 2 AA repeats of F-G

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000407019

144_206

441.0

Region

Binding to CDKN1B

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000407019

76_304

441.0

Region

Note=5 X 2 AA repeats of F-G

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000347635

113_114

469.0

Repeat

Note=2

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000347635

225_226

469.0

Repeat

Note=3

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000347635

273_274

469.0

Repeat

Note=4

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000347635

303_304

469.0

Repeat

Note=5

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000347635

76_77

469.0

Repeat

Note=1

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000396096

113_114

441.0

Repeat

Note=2

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000396096

225_226

441.0

Repeat

Note=3

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000396096

273_274

441.0

Repeat

Note=4

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000396096

303_304

441.0

Repeat

Note=5

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000396096

76_77

441.0

Repeat

Note=1

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000407019

113_114

441.0

Repeat

Note=2

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000407019

225_226

441.0

Repeat

Note=3

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000407019

273_274

441.0

Repeat

Note=4

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000407019

303_304

441.0

Repeat

Note=5

Tgene

NUP50

chrX:20187519

chr22:45567480

ENST00000407019

76_77

441.0

Repeat

Note=1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RPS6KA3

chrX:20187519

chr22:45567480

ENST00000379565

422_679

481

741.0

Domain

Protein kinase 2

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Fusion Gene Sequence for RPS6KA3-NUP50

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>78009_78009_1_RPS6KA3-NUP50_RPS6KA3_chrX_20187519_ENST00000379548_NUP50_chr22_45567480_ENST00000347635_length(transcript)=6074nt_BP=1376nt
ATCACCATCATGGTTTCGTAGCCATGTTTAAATTTTTGTCTTTTCGTGTTCGCTCTATACAGGAAGAAGTCAGTATCAAAGAAATTGCAA
TCACACATCATGTAAAGGAAGGACATGAAAAGGCAGATCCTTCCCAGTTTGAACTTTTAAAAGTATTAGGGCAGGGATCATTTGGAAAGG
TTTTCTTAGTTAAAAAAATCTCAGGCTCTGATGCTAGGCAGCTTTATGCCATGAAGGTATTGAAGAAGGCCACACTGAAAGTTCGAGACC
GAGTTCGGACAAAAATGGAACGTGATATCTTGGTAGAGGTTAATCATCCTTTTATTGTCAAGTTGCATTATGCTTTTCAAACTGAAGGGA
AGTTGTATCTTATTTTGGATTTTCTCAGGGGAGGAGATTTGTTTACACGCTTATCCAAAGAGGTGATGTTCACAGAAGAAGATGTCAAAT
TCTACTTGGCTGAACTTGCACTTGCTTTAGACCATCTACATAGCCTGGGAATAATTTATAGAGACTTAAAACCAGAAAATATACTTCTTG
ATGAAGAAGGTCACATCAAGTTAACAGATTTCGGCCTAAGTAAAGAGTCTATTGACCATGAAAAGAAGGCATATTCTTTTTGTGGAACTG
TGGAGTATATGGCTCCAGAAGTAGTTAATCGTCGAGGTCATACTCAGAGTGCTGACTGGTGGTCTTTTGGTGTGTTAATGTTTGAAATGC
TTACTGGTACACTCCCTTTCCAAGGAAAAGATCGAAAAGAAACAATGACTATGATTCTTAAAGCCAAACTTGGAATGCCACAGTTTTTGA
GTCCTGAAGCGCAGAGTCTTTTACGAATGCTTTTCAAGCGAAATCCTGCAAACAGATTAGGTGCAGGACCAGATGGAGTTGAAGAAATTA
AAAGACATTCATTTTTCTCAACGATAGACTGGAATAAACTGTATAGAAGAGAAATTCATCCGCCATTTAAACCTGCAACGGGCAGGCCTG
AAGATACATTCTATTTTGATCCTGAGTTTACTGCAAAAACTCCCAAAGATTCACCTGGCATTCCACCTAGTGCTAATGCACATCAGCTTT
TTCGGGGGTTTAGTTTTGTTGCTATTACCTCAGATGATGAAAGCCAAGCTATGCAGACAGTTGGTGTACATTCAATTGTTCAGTTACACA
GGAACAGTATTCAGTTTACTGATGGATATGAAGTAAAAGAAGATATTGGAGTTGGCTCCTACTCTGTTTGCAAGAGATGTATACATAAAG
CTACAAACATGGAGTTTGCAGTGAAGATTATTGATAAAAGCAAGAGAGACCCAACAGAAGAAATTGAAATTCTTCTTCGTTATGGACAGC
ATCCAAACATTATCACTCTAAAGGATGTGGGAACATTCTCCATGGCCAGTGAGGAAGTCTTGAAGAATAGAGCCATAAAGAAAGCAAAGC
GCAGAAATGTTGGATTTGAATCTGACACTGGAGGAGCCTTTAAAGGTTTTAAAGGTTTGGTGGTACCTTCTGGAGGAGGACGCTTTTCTG
GATTTGGTAGTGGCGCTGGAGGGAAGCCTTTGGAAGGACTGTCGAATGGAAACAACATAACCAGTGCCCCTCCCTTCGCCAGTGCAAAGG
CAGCGGCAGATCCCAAGGTAGCCTTTGGTTCTCTTGCTGCAAATGGCCCTACCACCTTGGTTGATAAAGTTTCAAATCCCAAAACTAATG
GGGACAGTCAGCAGCCCTCCTCCTCTGGCCTTGCTTCCAGTAAAGCTTGTGTCGGAAATGCCTATCACAAGCAGTTGGCCGCCTTGAACT
GCTCCGTGCGGGATTGGATAGTGAAGCACGTGAATACAAACCCCCTCTGTGATCTGACACCTATCTTTAAAGACTATGAGAAATATTTAG
CAAACATTGAACAGCAACACGGGAACAGTGGCAGGAATTCTGAAAGTGAATCTAACAAAGTGGCAGCTGAAACACAGTCTCCTTCCCTTT
TTGGCTCAACAAAATTACAGCAAGAGTCAACGTTTTTGTTTCATGGCAACAAAACTGAAGATACACCTGACAAGAAGATGGAGGTGGCAT
CTGAAAAGAAAACGGACCCATCATCACTAGGAGCGACAAGTGCCTCATTTAATTTCGGCAAGAAAGTTGATAGCTCTGTTTTGGGCTCAT
TAAGCTCTGTCCCCCTGACTGGATTTTCTTTCTCCCCTGGAAACTCCAGTTTATTTGGCAAAGATACTACCCAGAGTAAACCAGTCTCTT
CACCATTTCCCACTAAACCATTGGAGGGCCAAGCAGAAGGTGACAGTGGTGAATGCAAAGGTGGAGATGAAGAAGAGAATGATGAGCCAC
CCAAAGTAGTAGTTACCGAAGTAAAAGAAGAAGATGCTTTTTACTCCAAAAAGTGTAAACTGTTTTACAAGAAAGACAATGAGTTTAAAG
AGAAAGGCATAGGTACTCTGCATTTAAAACCTACAGCAAATCAGAAGACACAGCTTTTGGTGCGGGCAGACACCAATTTAGGCAACATAT
TGCTGAACGTTCTGATTCCACCCAATATGCCATGTACGCGAACAGGGAAGAATAACGTTCTTATCGTCTGTGTTCCAAATCCACCAATTG
ACGAGAAGAATGCCACCATGCCAGTCACCATGTTGATTCGGGTAAAAACCAGCGAGGATGCAGACGAGTTGCACAAAATTTTACTGGAGA
AAAAGGATGCCTGAACACGCAAAGTCGGCTGCAGAATTATTGCCAAGTTGCTGCTGCTTCCACCGCCCCTTAAAGTTAGTCAGTTTTTCT
TCTCTTCTTTGACATTCTAAGAACTTATAGATAACTTAAAACTTTTGTGAGGAAGATTAATGTGGCCAATAAAACCTTTAAATGTTAAGT
GTCAAGAAACTGCACTCTCCCTTCTTAAGAACTGCCTAAAGTGTAAAATACATTTGAATGCAATTTTTGGAAGATTTTTTAATGTTCGTT
TATTAAACTAACCCTAAGTGATTTCTTCAAGGACTGCAATCAGGGTATCAATTTGCTTTCCCAAAGGCTCTTCCAACCCGTGGGTTTTGG
GGTCCACCGCCACCACGAGAGAGGCTTTTGAACAGGTGCCTGGCTGTGTTCAGAAGGAAGCTGGCCTGTGTGCTTCTCTCCGGTGGGCTC
AGCCGACGTGTGAGACTTGTTCTGTTACCAAATGAACCGGGCTGCCACGCTGTGACAGGCGTTTGTCCTCTGCTTTATTTTTACTTTGAA
GCTCAAATGCGAGTACTAAGTGTTCACCTCAGCGTTCGAATCATTGGCCTGTAACCCTGTGGGCTGCTTCACGAGAATTCAGGACCTGCA
TTTTCATTCTAAAAAGAAATGAACAGCTTGTGAAGGAGTTTTTTGGCTTCATAGTTTCTATTCATGAGGTAGTGTTACTTCTTTATCCCC
CTAAAGACAAAATGAAGATAAAGGGGGATTGCCAGGAATGGGTTTAAAAGCACAAATGTGGTAGCTTATCATCTACACCATGGAGAGTGA
ACCCTTACGAAATGAAAGTCAAATGAGACCATCCGAGAAAAAGATGCGCATAGGCATTTGTACCATGATCAACCCCACGCACATGAAAAC
TGTGACCAAGTGACGTGCCTGGGAGCTTTGACACACGAGCCGTGTGAATTCACTAGGAAACATGTAATAAAGTCATGGAAGAGAAAATCG
TGTGTAAACTTTGCCTTTAACTTTAGACCGCAGTATATTATAATACATTTGATATCTGAAATATCTTTACTTTTTTAAGAGTAAGATTCC
ATATGTCTGTCTGGAAGGGAGCCATGGTTATTCACACGAATATCCCTGTCACTTCTCCAGAGGTGTCAGGTAACTAACACGAGCATTCTT
TGAAGACTCTGGGCACATGAATGATACACAGAATTGAATGTTTAAATTTCCACTGAGTCCTCATGAATCATTTGAGACTAGTACCAGCTG
ATCTTGTGTACAGGCTCAGGGTCAGTGCCCAAGGGCTCCCGCGTGTGTGTTCTGATCTTCAGTGCGTAGCACATTCTCCATTTAGAAAAG
AGTGGTCAGAATAATTGTGGACGGTACAGTGGCTTTTTAAAACTACAGTCTTTAGGTGTAAGGTTTGGCGCCGGGAGCAATTTTATGATC
AAATATGATGAACTCCTAAGTCACTGAGGTGTGATTGGGCCAATGTTGGCATGAGGTTCTTGCTCTACTTCCAGTGTTTTGATTCCACTG
GGAGAATTTGGCCTAGTGTGTGGCTTTGGATGAATCCGTGTAGAGAGAGGTGAGCTTGTCCTGTTACAGATGCTGTCAGACATAGCGATA
GTAGGCACCTAGGGAGGAAGTGGCCGTTAGTTTTACACTGACTTTTTAAGAATGGAGAATGCACGTGGGTTTCTGTTGCGGATGATTCAT
AGTAAGCAAGCGGTTGATGCTGTTAATACCGGCCCCACCCGATTGACATTAAGTTTATTCAGCTTTTAAAAAGATGAAGAACTAAGGGGA
ACAAATTTAAGTTTGTTGCAACTTAGCCACACATGCTTCCCTGGTACCAGCTGGAATCAGCAGCTCACAGGCATCTTCAGGACACTTCAG
TGTATATGACACAGTACTTTGTTAGCGTCTGCGTGTGTATGGAAAGTTGACAAAAAATGGCATGAAAAGATCATGATTGGATTTTCTTTT
AAACCTGCCCTTCTGTAAAAAATAGTTTATATATTTTTAAATTAGTAGGTATGTGTGGCTTCCTTTTTTCCTAACATTCCCAGCAAATTT
TTGCTGCTAAGACTATCACTGTTAAAGTGAAAATTACAGGGAAAAATGTGATGAATATACCGTAACTCAAAATGTGATATTTTCTTAAAA
TCACTCTTTTATGCTTTAGGAACTGGTTGGTCTCCACTTTGATTATTAGTGTAAAGAGCCTGAGTATACGTGGATTTCATTGTAAAATTT
AACTCCTTGTCTTTTACTTGGGGCACGGGGCCCCTGGAGGGCTTCCCTACTTTCCCCACTATGTTAACAGGTAATTCTGATTTATGCGTT
TAGTTTGACTTATTTTTAACAAAATATTAGAAGTTATGCTTTAAAATGTTTAATGTGGACTGAAATTTTCATCTTTTGTTTGAGAATCTA
TGAAGTGTATCATATACGTGGCCTAAAGCAAGGTGTGTATTTTGTTATTCTGAAATTGTTTTGCATCTGGACAAATACTAAATATCCCAG
TGGCCTTTTTTTTTTTTTTTTTAAAACCTGTGTATCCATCTCATCCTTTTGCGCATTCCTAGTAAGCAAAAAAATTTGTTATGCCATCTT
CATTATTCGAATTACAGACTGAAAAAATATGGCCAGTTTTTAAAGAAGTTTAGATTATGTTTTCCATGGAAGGACAAGTCTGACTGTTCA
TAGGCTGATTTTCTTTAAGAGGATTATTCTGTTTTACAATTTCAATTCTAGATCACATTTTATATATGCTGCATGCCAAAAAAAAAAAAA
AGAGAAAACTGCCTTTTCTGGTGTGGAGGGGAAGAAAAACTAATATTCTACCTTACTAGTAGAGTTCAAAACAAGTTTTCACTGAGAGCC
TTTTCAGTAAAAGTTAAACAAGTTTGTTTTTTGAGCATTTGTCAGTTATTCTATTTCAGAAGAGTCAAAATTCAAGCACGATACATTTTG
AAGGCTTTGCAAACTCCTAAACCCCTGATGAGTCCTCTCATTCTGGAAGTGGGAATTTGAGTAGATACTGATTTGTCCCGTAGTATGGCA
GATGACAGGGAGGTCTTTTCCAAGCAGGCACTCAGAACACAGGTCACCGTATGTTCTCAGCCAGTAACAATCATACTGAGGACGAAGGAC
TCTCCGTTTGATGCAGACACAATTGTAATGGAGATGTAAAACTTCTTAGCAATCAGATGGATAAATTGTTTGCTTTTTACTTTAAATAGG
AAATTGTTTTCTAAAACTAAAATACTTGAATTGTCAGACAATATAATCTCAGCTTGTATTAGTTTTTGAATGCTCCCATCGAGGAAGTGT

>78009_78009_1_RPS6KA3-NUP50_RPS6KA3_chrX_20187519_ENST00000379548_NUP50_chr22_45567480_ENST00000347635_length(amino acids)=896AA_BP=451
MFKFLSFRVRSIQEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMER
DILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKL
TDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLL
RMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVA
ITSDDESQAMQTVGVHSIVQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLK
DVGTFSMASEEVLKNRAIKKAKRRNVGFESDTGGAFKGFKGLVVPSGGGRFSGFGSGAGGKPLEGLSNGNNITSAPPFASAKAAADPKVA
FGSLAANGPTTLVDKVSNPKTNGDSQQPSSSGLASSKACVGNAYHKQLAALNCSVRDWIVKHVNTNPLCDLTPIFKDYEKYLANIEQQHG
NSGRNSESESNKVAAETQSPSLFGSTKLQQESTFLFHGNKTEDTPDKKMEVASEKKTDPSSLGATSASFNFGKKVDSSVLGSLSSVPLTG
FSFSPGNSSLFGKDTTQSKPVSSPFPTKPLEGQAEGDSGECKGGDEEENDEPPKVVVTEVKEEDAFYSKKCKLFYKKDNEFKEKGIGTLH

--------------------------------------------------------------
>78009_78009_2_RPS6KA3-NUP50_RPS6KA3_chrX_20187519_ENST00000379565_NUP50_chr22_45567480_ENST00000347635_length(transcript)=6349nt_BP=1651nt
AGGCGCGCGGCTTTCGGGCGGTCGGCGTCGGCGTCGAGCCCTCTCTGGGGCCGCCGCCGCTGCTGCTGCTGCTGCCGCTGCCGCTGCCGC
TGCCGCCGCCGCCGCCGCCGCCGCCGCTGCCGTGGGGCTCGGGCGGCGACGGAGCGGGGCCGGCCGTGGGGCGGGCGGGGAGGGAGGAGG
CGGTGAAGGCGGCGGGCCGGGGGGGAAGATGCCGCTGGCGCAGCTGGCGGACCCGTGGCAGAAGATGGCTGTGGAGAGCCCGTCCGACAG
CGCTGAGAATGGACAGCAAATTATGGATGAACCTATGGGAGAGGAGGAGATTAACCCACAAACTGAAGAAGTCAGTATCAAAGAAATTGC
AATCACACATCATGTAAAGGAAGGACATGAAAAGGCAGATCCTTCCCAGTTTGAACTTTTAAAAGTATTAGGGCAGGGATCATTTGGAAA
GGTTTTCTTAGTTAAAAAAATCTCAGGCTCTGATGCTAGGCAGCTTTATGCCATGAAGGTATTGAAGAAGGCCACACTGAAAGTTCGAGA
CCGAGTTCGGACAAAAATGGAACGTGATATCTTGGTAGAGGTTAATCATCCTTTTATTGTCAAGTTGCATTATGCTTTTCAAACTGAAGG
GAAGTTGTATCTTATTTTGGATTTTCTCAGGGGAGGAGATTTGTTTACACGCTTATCCAAAGAGGTGATGTTCACAGAAGAAGATGTCAA
ATTCTACTTGGCTGAACTTGCACTTGCTTTAGACCATCTACATAGCCTGGGAATAATTTATAGAGACTTAAAACCAGAAAATATACTTCT
TGATGAAGAAGGTCACATCAAGTTAACAGATTTCGGCCTAAGTAAAGAGTCTATTGACCATGAAAAGAAGGCATATTCTTTTTGTGGAAC
TGTGGAGTATATGGCTCCAGAAGTAGTTAATCGTCGAGGTCATACTCAGAGTGCTGACTGGTGGTCTTTTGGTGTGTTAATGTTTGAAAT
GCTTACTGGTACACTCCCTTTCCAAGGAAAAGATCGAAAAGAAACAATGACTATGATTCTTAAAGCCAAACTTGGAATGCCACAGTTTTT
GAGTCCTGAAGCGCAGAGTCTTTTACGAATGCTTTTCAAGCGAAATCCTGCAAACAGATTAGGTGCAGGACCAGATGGAGTTGAAGAAAT
TAAAAGACATTCATTTTTCTCAACGATAGACTGGAATAAACTGTATAGAAGAGAAATTCATCCGCCATTTAAACCTGCAACGGGCAGGCC
TGAAGATACATTCTATTTTGATCCTGAGTTTACTGCAAAAACTCCCAAAGATTCACCTGGCATTCCACCTAGTGCTAATGCACATCAGCT
TTTTCGGGGGTTTAGTTTTGTTGCTATTACCTCAGATGATGAAAGCCAAGCTATGCAGACAGTTGGTGTACATTCAATTGTTCAGCAGTT
ACACAGGAACAGTATTCAGTTTACTGATGGATATGAAGTAAAAGAAGATATTGGAGTTGGCTCCTACTCTGTTTGCAAGAGATGTATACA
TAAAGCTACAAACATGGAGTTTGCAGTGAAGATTATTGATAAAAGCAAGAGAGACCCAACAGAAGAAATTGAAATTCTTCTTCGTTATGG
ACAGCATCCAAACATTATCACTCTAAAGGATGTGGGAACATTCTCCATGGCCAGTGAGGAAGTCTTGAAGAATAGAGCCATAAAGAAAGC
AAAGCGCAGAAATGTTGGATTTGAATCTGACACTGGAGGAGCCTTTAAAGGTTTTAAAGGTTTGGTGGTACCTTCTGGAGGAGGACGCTT
TTCTGGATTTGGTAGTGGCGCTGGAGGGAAGCCTTTGGAAGGACTGTCGAATGGAAACAACATAACCAGTGCCCCTCCCTTCGCCAGTGC
AAAGGCAGCGGCAGATCCCAAGGTAGCCTTTGGTTCTCTTGCTGCAAATGGCCCTACCACCTTGGTTGATAAAGTTTCAAATCCCAAAAC
TAATGGGGACAGTCAGCAGCCCTCCTCCTCTGGCCTTGCTTCCAGTAAAGCTTGTGTCGGAAATGCCTATCACAAGCAGTTGGCCGCCTT
GAACTGCTCCGTGCGGGATTGGATAGTGAAGCACGTGAATACAAACCCCCTCTGTGATCTGACACCTATCTTTAAAGACTATGAGAAATA
TTTAGCAAACATTGAACAGCAACACGGGAACAGTGGCAGGAATTCTGAAAGTGAATCTAACAAAGTGGCAGCTGAAACACAGTCTCCTTC
CCTTTTTGGCTCAACAAAATTACAGCAAGAGTCAACGTTTTTGTTTCATGGCAACAAAACTGAAGATACACCTGACAAGAAGATGGAGGT
GGCATCTGAAAAGAAAACGGACCCATCATCACTAGGAGCGACAAGTGCCTCATTTAATTTCGGCAAGAAAGTTGATAGCTCTGTTTTGGG
CTCATTAAGCTCTGTCCCCCTGACTGGATTTTCTTTCTCCCCTGGAAACTCCAGTTTATTTGGCAAAGATACTACCCAGAGTAAACCAGT
CTCTTCACCATTTCCCACTAAACCATTGGAGGGCCAAGCAGAAGGTGACAGTGGTGAATGCAAAGGTGGAGATGAAGAAGAGAATGATGA
GCCACCCAAAGTAGTAGTTACCGAAGTAAAAGAAGAAGATGCTTTTTACTCCAAAAAGTGTAAACTGTTTTACAAGAAAGACAATGAGTT
TAAAGAGAAAGGCATAGGTACTCTGCATTTAAAACCTACAGCAAATCAGAAGACACAGCTTTTGGTGCGGGCAGACACCAATTTAGGCAA
CATATTGCTGAACGTTCTGATTCCACCCAATATGCCATGTACGCGAACAGGGAAGAATAACGTTCTTATCGTCTGTGTTCCAAATCCACC
AATTGACGAGAAGAATGCCACCATGCCAGTCACCATGTTGATTCGGGTAAAAACCAGCGAGGATGCAGACGAGTTGCACAAAATTTTACT
GGAGAAAAAGGATGCCTGAACACGCAAAGTCGGCTGCAGAATTATTGCCAAGTTGCTGCTGCTTCCACCGCCCCTTAAAGTTAGTCAGTT
TTTCTTCTCTTCTTTGACATTCTAAGAACTTATAGATAACTTAAAACTTTTGTGAGGAAGATTAATGTGGCCAATAAAACCTTTAAATGT
TAAGTGTCAAGAAACTGCACTCTCCCTTCTTAAGAACTGCCTAAAGTGTAAAATACATTTGAATGCAATTTTTGGAAGATTTTTTAATGT
TCGTTTATTAAACTAACCCTAAGTGATTTCTTCAAGGACTGCAATCAGGGTATCAATTTGCTTTCCCAAAGGCTCTTCCAACCCGTGGGT
TTTGGGGTCCACCGCCACCACGAGAGAGGCTTTTGAACAGGTGCCTGGCTGTGTTCAGAAGGAAGCTGGCCTGTGTGCTTCTCTCCGGTG
GGCTCAGCCGACGTGTGAGACTTGTTCTGTTACCAAATGAACCGGGCTGCCACGCTGTGACAGGCGTTTGTCCTCTGCTTTATTTTTACT
TTGAAGCTCAAATGCGAGTACTAAGTGTTCACCTCAGCGTTCGAATCATTGGCCTGTAACCCTGTGGGCTGCTTCACGAGAATTCAGGAC
CTGCATTTTCATTCTAAAAAGAAATGAACAGCTTGTGAAGGAGTTTTTTGGCTTCATAGTTTCTATTCATGAGGTAGTGTTACTTCTTTA
TCCCCCTAAAGACAAAATGAAGATAAAGGGGGATTGCCAGGAATGGGTTTAAAAGCACAAATGTGGTAGCTTATCATCTACACCATGGAG
AGTGAACCCTTACGAAATGAAAGTCAAATGAGACCATCCGAGAAAAAGATGCGCATAGGCATTTGTACCATGATCAACCCCACGCACATG
AAAACTGTGACCAAGTGACGTGCCTGGGAGCTTTGACACACGAGCCGTGTGAATTCACTAGGAAACATGTAATAAAGTCATGGAAGAGAA
AATCGTGTGTAAACTTTGCCTTTAACTTTAGACCGCAGTATATTATAATACATTTGATATCTGAAATATCTTTACTTTTTTAAGAGTAAG
ATTCCATATGTCTGTCTGGAAGGGAGCCATGGTTATTCACACGAATATCCCTGTCACTTCTCCAGAGGTGTCAGGTAACTAACACGAGCA
TTCTTTGAAGACTCTGGGCACATGAATGATACACAGAATTGAATGTTTAAATTTCCACTGAGTCCTCATGAATCATTTGAGACTAGTACC
AGCTGATCTTGTGTACAGGCTCAGGGTCAGTGCCCAAGGGCTCCCGCGTGTGTGTTCTGATCTTCAGTGCGTAGCACATTCTCCATTTAG
AAAAGAGTGGTCAGAATAATTGTGGACGGTACAGTGGCTTTTTAAAACTACAGTCTTTAGGTGTAAGGTTTGGCGCCGGGAGCAATTTTA
TGATCAAATATGATGAACTCCTAAGTCACTGAGGTGTGATTGGGCCAATGTTGGCATGAGGTTCTTGCTCTACTTCCAGTGTTTTGATTC
CACTGGGAGAATTTGGCCTAGTGTGTGGCTTTGGATGAATCCGTGTAGAGAGAGGTGAGCTTGTCCTGTTACAGATGCTGTCAGACATAG
CGATAGTAGGCACCTAGGGAGGAAGTGGCCGTTAGTTTTACACTGACTTTTTAAGAATGGAGAATGCACGTGGGTTTCTGTTGCGGATGA
TTCATAGTAAGCAAGCGGTTGATGCTGTTAATACCGGCCCCACCCGATTGACATTAAGTTTATTCAGCTTTTAAAAAGATGAAGAACTAA
GGGGAACAAATTTAAGTTTGTTGCAACTTAGCCACACATGCTTCCCTGGTACCAGCTGGAATCAGCAGCTCACAGGCATCTTCAGGACAC
TTCAGTGTATATGACACAGTACTTTGTTAGCGTCTGCGTGTGTATGGAAAGTTGACAAAAAATGGCATGAAAAGATCATGATTGGATTTT
CTTTTAAACCTGCCCTTCTGTAAAAAATAGTTTATATATTTTTAAATTAGTAGGTATGTGTGGCTTCCTTTTTTCCTAACATTCCCAGCA
AATTTTTGCTGCTAAGACTATCACTGTTAAAGTGAAAATTACAGGGAAAAATGTGATGAATATACCGTAACTCAAAATGTGATATTTTCT
TAAAATCACTCTTTTATGCTTTAGGAACTGGTTGGTCTCCACTTTGATTATTAGTGTAAAGAGCCTGAGTATACGTGGATTTCATTGTAA
AATTTAACTCCTTGTCTTTTACTTGGGGCACGGGGCCCCTGGAGGGCTTCCCTACTTTCCCCACTATGTTAACAGGTAATTCTGATTTAT
GCGTTTAGTTTGACTTATTTTTAACAAAATATTAGAAGTTATGCTTTAAAATGTTTAATGTGGACTGAAATTTTCATCTTTTGTTTGAGA
ATCTATGAAGTGTATCATATACGTGGCCTAAAGCAAGGTGTGTATTTTGTTATTCTGAAATTGTTTTGCATCTGGACAAATACTAAATAT
CCCAGTGGCCTTTTTTTTTTTTTTTTTAAAACCTGTGTATCCATCTCATCCTTTTGCGCATTCCTAGTAAGCAAAAAAATTTGTTATGCC
ATCTTCATTATTCGAATTACAGACTGAAAAAATATGGCCAGTTTTTAAAGAAGTTTAGATTATGTTTTCCATGGAAGGACAAGTCTGACT
GTTCATAGGCTGATTTTCTTTAAGAGGATTATTCTGTTTTACAATTTCAATTCTAGATCACATTTTATATATGCTGCATGCCAAAAAAAA
AAAAAAGAGAAAACTGCCTTTTCTGGTGTGGAGGGGAAGAAAAACTAATATTCTACCTTACTAGTAGAGTTCAAAACAAGTTTTCACTGA
GAGCCTTTTCAGTAAAAGTTAAACAAGTTTGTTTTTTGAGCATTTGTCAGTTATTCTATTTCAGAAGAGTCAAAATTCAAGCACGATACA
TTTTGAAGGCTTTGCAAACTCCTAAACCCCTGATGAGTCCTCTCATTCTGGAAGTGGGAATTTGAGTAGATACTGATTTGTCCCGTAGTA
TGGCAGATGACAGGGAGGTCTTTTCCAAGCAGGCACTCAGAACACAGGTCACCGTATGTTCTCAGCCAGTAACAATCATACTGAGGACGA
AGGACTCTCCGTTTGATGCAGACACAATTGTAATGGAGATGTAAAACTTCTTAGCAATCAGATGGATAAATTGTTTGCTTTTTACTTTAA
ATAGGAAATTGTTTTCTAAAACTAAAATACTTGAATTGTCAGACAATATAATCTCAGCTTGTATTAGTTTTTGAATGCTCCCATCGAGGA

>78009_78009_2_RPS6KA3-NUP50_RPS6KA3_chrX_20187519_ENST00000379565_NUP50_chr22_45567480_ENST00000347635_length(amino acids)=926AA_BP=481
MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISG
SDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA
LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQG
KDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPE
FTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAV
KIIDKSKRDPTEEIEILLRYGQHPNIITLKDVGTFSMASEEVLKNRAIKKAKRRNVGFESDTGGAFKGFKGLVVPSGGGRFSGFGSGAGG
KPLEGLSNGNNITSAPPFASAKAAADPKVAFGSLAANGPTTLVDKVSNPKTNGDSQQPSSSGLASSKACVGNAYHKQLAALNCSVRDWIV
KHVNTNPLCDLTPIFKDYEKYLANIEQQHGNSGRNSESESNKVAAETQSPSLFGSTKLQQESTFLFHGNKTEDTPDKKMEVASEKKTDPS
SLGATSASFNFGKKVDSSVLGSLSSVPLTGFSFSPGNSSLFGKDTTQSKPVSSPFPTKPLEGQAEGDSGECKGGDEEENDEPPKVVVTEV
KEEDAFYSKKCKLFYKKDNEFKEKGIGTLHLKPTANQKTQLLVRADTNLGNILLNVLIPPNMPCTRTGKNNVLIVCVPNPPIDEKNATMP

--------------------------------------------------------------
>78009_78009_3_RPS6KA3-NUP50_RPS6KA3_chrX_20187519_ENST00000540702_NUP50_chr22_45567480_ENST00000347635_length(transcript)=6202nt_BP=1504nt
AGGATTATATCTTTATCCTTGAAATTTAAAAACATTTGCCAGGACATGTCTTGGTGTTGATGATCTCTGTTGAACCTTCTCAGTCTCCAG
TCTCAGGATAAATGAGGAGCTGATTCTTAATCCTGTCACATTGAATGGACAGCAAATTATGGATGAACCTATGGGAGAGGAGGAGATTAA
CCCACAAACTGAAGAAGTCAGTATCAAAGAAATTGCAATCACACATCATGTAAAGGAAGGACATGAAAAGGCAGATCCTTCCCAGTTTGA
ACTTTTAAAAGTATTAGGGCAGGGATCATTTGGAAAGGTTTTCTTAGTTAAAAAAATCTCAGGCTCTGATGCTAGGCAGCTTTATGCCAT
GAAGGTATTGAAGAAGGCCACACTGAAAGTTCGAGACCGAGTTCGGACAAAAATGGAACGTGATATCTTGGTAGAGGTTAATCATCCTTT
TATTGTCAAGTTGCATTATGCTTTTCAAACTGAAGGGAAGTTGTATCTTATTTTGGATTTTCTCAGGGGAGGAGATTTGTTTACACGCTT
ATCCAAAGAGGTGATGTTCACAGAAGAAGATGTCAAATTCTACTTGGCTGAACTTGCACTTGCTTTAGACCATCTACATAGCCTGGGAAT
AATTTATAGAGACTTAAAACCAGAAAATATACTTCTTGATGAAGAAGGTCACATCAAGTTAACAGATTTCGGCCTAAGTAAAGAGTCTAT
TGACCATGAAAAGAAGGCATATTCTTTTTGTGGAACTGTGGAGTATATGGCTCCAGAAGTAGTTAATCGTCGAGGTCATACTCAGAGTGC
TGACTGGTGGTCTTTTGGTGTGTTAATGTTTGAAATGCTTACTGGTACACTCCCTTTCCAAGGAAAAGATCGAAAAGAAACAATGACTAT
GATTCTTAAAGCCAAACTTGGAATGCCACAGTTTTTGAGTCCTGAAGCGCAGAGTCTTTTACGAATGCTTTTCAAGCGAAATCCTGCAAA
CAGATTAGGTGCAGGACCAGATGGAGTTGAAGAAATTAAAAGACATTCATTTTTCTCAACGATAGACTGGAATAAACTGTATAGAAGAGA
AATTCATCCGCCATTTAAACCTGCAACGGGCAGGCCTGAAGATACATTCTATTTTGATCCTGAGTTTACTGCAAAAACTCCCAAAGATTC
ACCTGGCATTCCACCTAGTGCTAATGCACATCAGCTTTTTCGGGGGTTTAGTTTTGTTGCTATTACCTCAGATGATGAAAGCCAAGCTAT
GCAGACAGTTGGTGTACATTCAATTGTTCAGTTACACAGGAACAGTATTCAGTTTACTGATGGATATGAAGTAAAAGAAGATATTGGAGT
TGGCTCCTACTCTGTTTGCAAGAGATGTATACATAAAGCTACAAACATGGAGTTTGCAGTGAAGATTATTGATAAAAGCAAGAGAGACCC
AACAGAAGAAATTGAAATTCTTCTTCGTTATGGACAGCATCCAAACATTATCACTCTAAAGGATGTGGGAACATTCTCCATGGCCAGTGA
GGAAGTCTTGAAGAATAGAGCCATAAAGAAAGCAAAGCGCAGAAATGTTGGATTTGAATCTGACACTGGAGGAGCCTTTAAAGGTTTTAA
AGGTTTGGTGGTACCTTCTGGAGGAGGACGCTTTTCTGGATTTGGTAGTGGCGCTGGAGGGAAGCCTTTGGAAGGACTGTCGAATGGAAA
CAACATAACCAGTGCCCCTCCCTTCGCCAGTGCAAAGGCAGCGGCAGATCCCAAGGTAGCCTTTGGTTCTCTTGCTGCAAATGGCCCTAC
CACCTTGGTTGATAAAGTTTCAAATCCCAAAACTAATGGGGACAGTCAGCAGCCCTCCTCCTCTGGCCTTGCTTCCAGTAAAGCTTGTGT
CGGAAATGCCTATCACAAGCAGTTGGCCGCCTTGAACTGCTCCGTGCGGGATTGGATAGTGAAGCACGTGAATACAAACCCCCTCTGTGA
TCTGACACCTATCTTTAAAGACTATGAGAAATATTTAGCAAACATTGAACAGCAACACGGGAACAGTGGCAGGAATTCTGAAAGTGAATC
TAACAAAGTGGCAGCTGAAACACAGTCTCCTTCCCTTTTTGGCTCAACAAAATTACAGCAAGAGTCAACGTTTTTGTTTCATGGCAACAA
AACTGAAGATACACCTGACAAGAAGATGGAGGTGGCATCTGAAAAGAAAACGGACCCATCATCACTAGGAGCGACAAGTGCCTCATTTAA
TTTCGGCAAGAAAGTTGATAGCTCTGTTTTGGGCTCATTAAGCTCTGTCCCCCTGACTGGATTTTCTTTCTCCCCTGGAAACTCCAGTTT
ATTTGGCAAAGATACTACCCAGAGTAAACCAGTCTCTTCACCATTTCCCACTAAACCATTGGAGGGCCAAGCAGAAGGTGACAGTGGTGA
ATGCAAAGGTGGAGATGAAGAAGAGAATGATGAGCCACCCAAAGTAGTAGTTACCGAAGTAAAAGAAGAAGATGCTTTTTACTCCAAAAA
GTGTAAACTGTTTTACAAGAAAGACAATGAGTTTAAAGAGAAAGGCATAGGTACTCTGCATTTAAAACCTACAGCAAATCAGAAGACACA
GCTTTTGGTGCGGGCAGACACCAATTTAGGCAACATATTGCTGAACGTTCTGATTCCACCCAATATGCCATGTACGCGAACAGGGAAGAA
TAACGTTCTTATCGTCTGTGTTCCAAATCCACCAATTGACGAGAAGAATGCCACCATGCCAGTCACCATGTTGATTCGGGTAAAAACCAG
CGAGGATGCAGACGAGTTGCACAAAATTTTACTGGAGAAAAAGGATGCCTGAACACGCAAAGTCGGCTGCAGAATTATTGCCAAGTTGCT
GCTGCTTCCACCGCCCCTTAAAGTTAGTCAGTTTTTCTTCTCTTCTTTGACATTCTAAGAACTTATAGATAACTTAAAACTTTTGTGAGG
AAGATTAATGTGGCCAATAAAACCTTTAAATGTTAAGTGTCAAGAAACTGCACTCTCCCTTCTTAAGAACTGCCTAAAGTGTAAAATACA
TTTGAATGCAATTTTTGGAAGATTTTTTAATGTTCGTTTATTAAACTAACCCTAAGTGATTTCTTCAAGGACTGCAATCAGGGTATCAAT
TTGCTTTCCCAAAGGCTCTTCCAACCCGTGGGTTTTGGGGTCCACCGCCACCACGAGAGAGGCTTTTGAACAGGTGCCTGGCTGTGTTCA
GAAGGAAGCTGGCCTGTGTGCTTCTCTCCGGTGGGCTCAGCCGACGTGTGAGACTTGTTCTGTTACCAAATGAACCGGGCTGCCACGCTG
TGACAGGCGTTTGTCCTCTGCTTTATTTTTACTTTGAAGCTCAAATGCGAGTACTAAGTGTTCACCTCAGCGTTCGAATCATTGGCCTGT
AACCCTGTGGGCTGCTTCACGAGAATTCAGGACCTGCATTTTCATTCTAAAAAGAAATGAACAGCTTGTGAAGGAGTTTTTTGGCTTCAT
AGTTTCTATTCATGAGGTAGTGTTACTTCTTTATCCCCCTAAAGACAAAATGAAGATAAAGGGGGATTGCCAGGAATGGGTTTAAAAGCA
CAAATGTGGTAGCTTATCATCTACACCATGGAGAGTGAACCCTTACGAAATGAAAGTCAAATGAGACCATCCGAGAAAAAGATGCGCATA
GGCATTTGTACCATGATCAACCCCACGCACATGAAAACTGTGACCAAGTGACGTGCCTGGGAGCTTTGACACACGAGCCGTGTGAATTCA
CTAGGAAACATGTAATAAAGTCATGGAAGAGAAAATCGTGTGTAAACTTTGCCTTTAACTTTAGACCGCAGTATATTATAATACATTTGA
TATCTGAAATATCTTTACTTTTTTAAGAGTAAGATTCCATATGTCTGTCTGGAAGGGAGCCATGGTTATTCACACGAATATCCCTGTCAC
TTCTCCAGAGGTGTCAGGTAACTAACACGAGCATTCTTTGAAGACTCTGGGCACATGAATGATACACAGAATTGAATGTTTAAATTTCCA
CTGAGTCCTCATGAATCATTTGAGACTAGTACCAGCTGATCTTGTGTACAGGCTCAGGGTCAGTGCCCAAGGGCTCCCGCGTGTGTGTTC
TGATCTTCAGTGCGTAGCACATTCTCCATTTAGAAAAGAGTGGTCAGAATAATTGTGGACGGTACAGTGGCTTTTTAAAACTACAGTCTT
TAGGTGTAAGGTTTGGCGCCGGGAGCAATTTTATGATCAAATATGATGAACTCCTAAGTCACTGAGGTGTGATTGGGCCAATGTTGGCAT
GAGGTTCTTGCTCTACTTCCAGTGTTTTGATTCCACTGGGAGAATTTGGCCTAGTGTGTGGCTTTGGATGAATCCGTGTAGAGAGAGGTG
AGCTTGTCCTGTTACAGATGCTGTCAGACATAGCGATAGTAGGCACCTAGGGAGGAAGTGGCCGTTAGTTTTACACTGACTTTTTAAGAA
TGGAGAATGCACGTGGGTTTCTGTTGCGGATGATTCATAGTAAGCAAGCGGTTGATGCTGTTAATACCGGCCCCACCCGATTGACATTAA
GTTTATTCAGCTTTTAAAAAGATGAAGAACTAAGGGGAACAAATTTAAGTTTGTTGCAACTTAGCCACACATGCTTCCCTGGTACCAGCT
GGAATCAGCAGCTCACAGGCATCTTCAGGACACTTCAGTGTATATGACACAGTACTTTGTTAGCGTCTGCGTGTGTATGGAAAGTTGACA
AAAAATGGCATGAAAAGATCATGATTGGATTTTCTTTTAAACCTGCCCTTCTGTAAAAAATAGTTTATATATTTTTAAATTAGTAGGTAT
GTGTGGCTTCCTTTTTTCCTAACATTCCCAGCAAATTTTTGCTGCTAAGACTATCACTGTTAAAGTGAAAATTACAGGGAAAAATGTGAT
GAATATACCGTAACTCAAAATGTGATATTTTCTTAAAATCACTCTTTTATGCTTTAGGAACTGGTTGGTCTCCACTTTGATTATTAGTGT
AAAGAGCCTGAGTATACGTGGATTTCATTGTAAAATTTAACTCCTTGTCTTTTACTTGGGGCACGGGGCCCCTGGAGGGCTTCCCTACTT
TCCCCACTATGTTAACAGGTAATTCTGATTTATGCGTTTAGTTTGACTTATTTTTAACAAAATATTAGAAGTTATGCTTTAAAATGTTTA
ATGTGGACTGAAATTTTCATCTTTTGTTTGAGAATCTATGAAGTGTATCATATACGTGGCCTAAAGCAAGGTGTGTATTTTGTTATTCTG
AAATTGTTTTGCATCTGGACAAATACTAAATATCCCAGTGGCCTTTTTTTTTTTTTTTTTAAAACCTGTGTATCCATCTCATCCTTTTGC
GCATTCCTAGTAAGCAAAAAAATTTGTTATGCCATCTTCATTATTCGAATTACAGACTGAAAAAATATGGCCAGTTTTTAAAGAAGTTTA
GATTATGTTTTCCATGGAAGGACAAGTCTGACTGTTCATAGGCTGATTTTCTTTAAGAGGATTATTCTGTTTTACAATTTCAATTCTAGA
TCACATTTTATATATGCTGCATGCCAAAAAAAAAAAAAAGAGAAAACTGCCTTTTCTGGTGTGGAGGGGAAGAAAAACTAATATTCTACC
TTACTAGTAGAGTTCAAAACAAGTTTTCACTGAGAGCCTTTTCAGTAAAAGTTAAACAAGTTTGTTTTTTGAGCATTTGTCAGTTATTCT
ATTTCAGAAGAGTCAAAATTCAAGCACGATACATTTTGAAGGCTTTGCAAACTCCTAAACCCCTGATGAGTCCTCTCATTCTGGAAGTGG
GAATTTGAGTAGATACTGATTTGTCCCGTAGTATGGCAGATGACAGGGAGGTCTTTTCCAAGCAGGCACTCAGAACACAGGTCACCGTAT
GTTCTCAGCCAGTAACAATCATACTGAGGACGAAGGACTCTCCGTTTGATGCAGACACAATTGTAATGGAGATGTAAAACTTCTTAGCAA
TCAGATGGATAAATTGTTTGCTTTTTACTTTAAATAGGAAATTGTTTTCTAAAACTAAAATACTTGAATTGTCAGACAATATAATCTCAG

>78009_78009_3_RPS6KA3-NUP50_RPS6KA3_chrX_20187519_ENST00000540702_NUP50_chr22_45567480_ENST00000347635_length(amino acids)=910AA_BP=465
MILNPVTLNGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKA
TLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLK
PENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKL
GMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPS
ANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEI
LLRYGQHPNIITLKDVGTFSMASEEVLKNRAIKKAKRRNVGFESDTGGAFKGFKGLVVPSGGGRFSGFGSGAGGKPLEGLSNGNNITSAP
PFASAKAAADPKVAFGSLAANGPTTLVDKVSNPKTNGDSQQPSSSGLASSKACVGNAYHKQLAALNCSVRDWIVKHVNTNPLCDLTPIFK
DYEKYLANIEQQHGNSGRNSESESNKVAAETQSPSLFGSTKLQQESTFLFHGNKTEDTPDKKMEVASEKKTDPSSLGATSASFNFGKKVD
SSVLGSLSSVPLTGFSFSPGNSSLFGKDTTQSKPVSSPFPTKPLEGQAEGDSGECKGGDEEENDEPPKVVVTEVKEEDAFYSKKCKLFYK
KDNEFKEKGIGTLHLKPTANQKTQLLVRADTNLGNILLNVLIPPNMPCTRTGKNNVLIVCVPNPPIDEKNATMPVTMLIRVKTSEDADEL

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Fusion Gene PPI Analysis for RPS6KA3-NUP50

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for RPS6KA3-NUP50

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for RPS6KA3-NUP50

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source