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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RPS6KA3-SH3KBP1 (FusionGDB2 ID:78012)

Fusion Gene Summary for RPS6KA3-SH3KBP1

check button Fusion gene summary
Fusion gene informationFusion gene name: RPS6KA3-SH3KBP1
Fusion gene ID: 78012
HgeneTgene
Gene symbol

RPS6KA3

SH3KBP1

Gene ID

6197

30011

Gene nameribosomal protein S6 kinase A3SH3 domain containing kinase binding protein 1
SynonymsCLS|HU-3|ISPK-1|MAPKAPK1B|MRX19|RSK|RSK2|S6K-alpha3|p90-RSK2|pp90RSK2AGMX2|CD2BP3|CIN85|GIG10|HSB-1|HSB1|IMD61|MIG18
Cytomap

Xp22.12

Xp22.12

Type of geneprotein-codingprotein-coding
Descriptionribosomal protein S6 kinase alpha-3MAP kinase-activated protein kinase 1bMAPK-activated protein kinase 1bMAPKAP kinase 1bMAPKAPK-1bRSK-2S6K-alpha-3epididymis secretory sperm binding proteininsulin-stimulated protein kinase 1p90-RSK 3ribosomal S6SH3 domain-containing kinase-binding protein 1CD2-binding protein 3SH3-domain kinase binding protein 1Src family kinase-binding protein 1c-Cbl-interacting proteincbl-interacting protein of 85 kDahuman Src family kinase-binding protein 1migration-in
Modification date2020032720200327
UniProtAcc.

SHKBP1

Ensembl transtripts involved in fusion geneENST00000379565, ENST00000540702, 
ENST00000544447, ENST00000379548, 
ENST00000479809, 		ENST00000379697, 
ENST00000477102, ENST00000541422, 
ENST00000379698, ENST00000379716, 
ENST00000397821, 
Fusion gene scores* DoF score15 X 11 X 7=115515 X 16 X 7=1680
# samples 1916
** MAII scorelog2(19/1155*10)=-2.60382152797247
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1680*10)=-3.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPS6KA3 [Title/Abstract] AND SH3KBP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRPS6KA3(20252876)-SH3KBP1(19663593), # samples:1
SH3KBP1(19854243)-RPS6KA3(20227522), # samples:1
Anticipated loss of major functional domain due to fusion event.RPS6KA3-SH3KBP1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
RPS6KA3-SH3KBP1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
RPS6KA3-SH3KBP1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
RPS6KA3-SH3KBP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPS6KA3

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

18402937


check buttonFusion gene breakpoints across RPS6KA3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SH3KBP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-8574-01ARPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-


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Fusion Gene ORF analysis for RPS6KA3-SH3KBP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000379565ENST00000379697RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-
5CDS-5UTRENST00000379565ENST00000477102RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-
5CDS-5UTRENST00000379565ENST00000541422RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-
5CDS-5UTRENST00000540702ENST00000379697RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-
5CDS-5UTRENST00000540702ENST00000477102RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-
5CDS-5UTRENST00000540702ENST00000541422RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-
5CDS-5UTRENST00000544447ENST00000379697RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-
5CDS-5UTRENST00000544447ENST00000477102RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-
5CDS-5UTRENST00000544447ENST00000541422RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-
Frame-shiftENST00000544447ENST00000379698RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-
Frame-shiftENST00000544447ENST00000379716RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-
Frame-shiftENST00000544447ENST00000397821RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-
In-frameENST00000379565ENST00000379698RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-
In-frameENST00000379565ENST00000379716RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-
In-frameENST00000379565ENST00000397821RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-
In-frameENST00000540702ENST00000379698RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-
In-frameENST00000540702ENST00000379716RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-
In-frameENST00000540702ENST00000397821RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-
intron-3CDSENST00000379548ENST00000379698RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-
intron-3CDSENST00000379548ENST00000379716RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-
intron-3CDSENST00000379548ENST00000397821RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-
intron-3CDSENST00000479809ENST00000379698RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-
intron-3CDSENST00000479809ENST00000379716RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-
intron-3CDSENST00000479809ENST00000397821RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-
intron-5UTRENST00000379548ENST00000379697RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-
intron-5UTRENST00000379548ENST00000477102RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-
intron-5UTRENST00000379548ENST00000541422RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-
intron-5UTRENST00000479809ENST00000379697RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-
intron-5UTRENST00000479809ENST00000477102RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-
intron-5UTRENST00000479809ENST00000541422RPS6KA3chrX

20252876

-SH3KBP1chrX

19663593

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000379565RPS6KA3chrX20252876-ENST00000397821SH3KBP1chrX19663593-40483342081605465
ENST00000379565RPS6KA3chrX20252876-ENST00000379716SH3KBP1chrX19663593-40163342081605465
ENST00000379565RPS6KA3chrX20252876-ENST00000379698SH3KBP1chrX19663593-23303342081605465
ENST00000540702RPS6KA3chrX20252876-ENST00000397821SH3KBP1chrX19663593-39041901091461450
ENST00000540702RPS6KA3chrX20252876-ENST00000379716SH3KBP1chrX19663593-38721901091461450
ENST00000540702RPS6KA3chrX20252876-ENST00000379698SH3KBP1chrX19663593-21861901091461450

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379565ENST00000397821RPS6KA3chrX20252876-SH3KBP1chrX19663593-0.0007322270.99926776
ENST00000379565ENST00000379716RPS6KA3chrX20252876-SH3KBP1chrX19663593-0.0007498010.9992501
ENST00000379565ENST00000379698RPS6KA3chrX20252876-SH3KBP1chrX19663593-0.0023987780.9976012
ENST00000540702ENST00000397821RPS6KA3chrX20252876-SH3KBP1chrX19663593-0.0009544310.99904555
ENST00000540702ENST00000379716RPS6KA3chrX20252876-SH3KBP1chrX19663593-0.0009507580.99904925
ENST00000540702ENST00000379698RPS6KA3chrX20252876-SH3KBP1chrX19663593-0.0028486310.99715143

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Fusion Genomic Features for RPS6KA3-SH3KBP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RPS6KA3-SH3KBP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:20252876/chrX:19663593)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.SH3KBP1

SHKBP1

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.707

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSH3KBP1chrX:20252876chrX:19663593ENST00000379698417602_664205629.0Coiled coilOntology_term=ECO:0000255
TgeneSH3KBP1chrX:20252876chrX:19663593ENST00000379716013602_6644428.0Coiled coilOntology_term=ECO:0000255
TgeneSH3KBP1chrX:20252876chrX:19663593ENST00000397821518602_664242666.0Coiled coilOntology_term=ECO:0000255
TgeneSH3KBP1chrX:20252876chrX:19663593ENST00000379698417327_428205629.0Compositional biasNote=Pro-rich
TgeneSH3KBP1chrX:20252876chrX:19663593ENST00000379716013327_4284428.0Compositional biasNote=Pro-rich
TgeneSH3KBP1chrX:20252876chrX:19663593ENST00000397821518327_428242666.0Compositional biasNote=Pro-rich
TgeneSH3KBP1chrX:20252876chrX:19663593ENST00000379698417267_328205629.0DomainSH3 3
TgeneSH3KBP1chrX:20252876chrX:19663593ENST000003797160131_584428.0DomainSH3 1
TgeneSH3KBP1chrX:20252876chrX:19663593ENST00000379716013267_3284428.0DomainSH3 3
TgeneSH3KBP1chrX:20252876chrX:19663593ENST0000037971601398_1574428.0DomainSH3 2
TgeneSH3KBP1chrX:20252876chrX:19663593ENST00000397821518267_328242666.0DomainSH3 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRPS6KA3chrX:20252876chrX:19663593ENST00000379565-222328_39742741.0DomainAGC-kinase C-terminal
HgeneRPS6KA3chrX:20252876chrX:19663593ENST00000379565-222422_67942741.0DomainProtein kinase 2
HgeneRPS6KA3chrX:20252876chrX:19663593ENST00000379565-22268_32742741.0DomainProtein kinase 1
HgeneRPS6KA3chrX:20252876chrX:19663593ENST00000379565-222428_43642741.0Nucleotide bindingATP
HgeneRPS6KA3chrX:20252876chrX:19663593ENST00000379565-22274_8242741.0Nucleotide bindingATP
TgeneSH3KBP1chrX:20252876chrX:19663593ENST000003796984171_58205629.0DomainSH3 1
TgeneSH3KBP1chrX:20252876chrX:19663593ENST0000037969841798_157205629.0DomainSH3 2
TgeneSH3KBP1chrX:20252876chrX:19663593ENST000003978215181_58242666.0DomainSH3 1
TgeneSH3KBP1chrX:20252876chrX:19663593ENST0000039782151898_157242666.0DomainSH3 2


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Fusion Gene Sequence for RPS6KA3-SH3KBP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>78012_78012_1_RPS6KA3-SH3KBP1_RPS6KA3_chrX_20252876_ENST00000379565_SH3KBP1_chrX_19663593_ENST00000379698_length(transcript)=2330nt_BP=334nt
AGGCGCGCGGCTTTCGGGCGGTCGGCGTCGGCGTCGAGCCCTCTCTGGGGCCGCCGCCGCTGCTGCTGCTGCTGCCGCTGCCGCTGCCGC
TGCCGCCGCCGCCGCCGCCGCCGCCGCTGCCGTGGGGCTCGGGCGGCGACGGAGCGGGGCCGGCCGTGGGGCGGGCGGGGAGGGAGGAGG
CGGTGAAGGCGGCGGGCCGGGGGGGAAGATGCCGCTGGCGCAGCTGGCGGACCCGTGGCAGAAGATGGCTGTGGAGAGCCCGTCCGACAG
CGCTGAGAATGGACAGCAAATTATGGATGAACCTATGGGAGAGGAGGAGATTAACCCACAAACTACTATTGGGAAGAAGTTACCTGCAAC
TACAGCAACTCCAGACTCATCAAAAACAGAAATGGACAGCAGGACAAAGAGCAAGGATTACTGCAAAGTAATATTTCCATATGAGGCACA
GAATGATGATGAATTGACAATCAAAGAAGGAGATATAGTCACTCTCATCAATAAGGACTGCATCGACGTAGGCTGGTGGGAAGGAGAGCT
GAACGGCAGACGAGGCGTGTTCCCCGATAACTTCGTGAAGTTACTTCCACCGGACTTTGAAAAGGAAGGGAATAGACCCAAGAAGCCACC
GCCTCCATCCGCTCCTGTCATCAAACAAGGGGCAGGCACCACTGAGAGAAAACATGAAATTAAAAAGATACCTCCTGAAAGACCAGAAAT
GCTTCCAAACAGAACAGAAGAAAAAGAAAGACCAGAGAGAGAGCCAAAACTGGATTTACAGAAGCCCTCCGTTCCTGCCATACCGCCAAA
AAAGCCTCGGCCACCTAAGACCAATTCTCTCAGCAGACCTGGCGCACTGCCCCCGAGAAGGCCGGAGAGACCGGTGGGTCCGCTGACACA
CACCAGGGGTGACAGTCCAAAGATTGACTTGGCCGGCAGTTCGCTATCTGGCATCCTGGACAAAGATCTCTCGGACCGCAGCAATGACAT
TGACTTAGAAGGTTTTGACTCCGTGGTATCATCTACTGAGAAACTCAGTCATCCGACCACAAGCAGACCAAAAGCTACAGGGAGGCGGCC
TCCGTCCCAGTCCCTCACATCTTCATCCCTTTCAAGCCCTGATATCTTCGACTCCCCAAGTCCCGAAGAGGATAAGGAGGAACACATTTC
ACTTGCGCACAGAGGAGTGGACGCGTCAAAGAAAACTTCCAAGACTGTTACCATATCCCAAGTGTCTGACAACAAAGCATCCCTGCCGCC
CAAGCCGGGGACCATGGCAGCAGGTGGCGGTGGGCCAGCCCCTCTGTCCTCAGCGGCGCCCTCCCCCCTGTCATCCTCTTTGGGAACAGC
TGGACACAGAGCCAACTCCCCGTCTCTGTTCGGCACGGAAGGAAAACCAAAGATGGAGCCTGCGGCCAGCAGCCAGGCGGCCGTGGAGGA
GCTAAGGACACAGGTCCGCGAGCTGAGGAGCATCATCGAGACCATGAAGGACCAGCAGAAACGAGAGATTAAACAGTTATTGTCTGAGTT
GGATGAAGAGAAGAAAATCCGGCTTCGGTTGCAGATGGAAGTGAACGACATAAAGAAAGCTCTACAATCAAAATGAATACTTGATCAATG
AAATGTCACATTATTCATCCTGAGTCCGAGACTCAAATTTTCTGCCCCAGCCAAAATAATCTTGTGCCAAAAGATTAAAGGTTTGCCTCA
AAATGTCCCTGTTTGAAAGATTAGCACAAAAGTCTTGATAGCACAACACAAATTCCATCCAAGAGGAGAATCTTCCCCAGGGTTTAGTCC
TGGGGCTGGCACTCGTTGTGACTTACACAGAGCAAAATTGTGCTAAAGGCTTTTCTACTCTGAGATCTCAATGCGAAATGAAAACTCAGG
CAGTTTAGTCCATAGTGGTACTATTTTGATGATATTTTCCATTAATAAAATGTAATTTCAGATTATTCGTTTACAAGCTTTATAATTTTA
TGATTTTTTAATCGTGTTTTGTCACAGACTTCCCTAGTGTTTGTACTACACGTAGTCAGAAGCGAGTGTCCTTTTCTTTTGCTTCAGGCT
AAGAGCTGCCTCGCTCTTTGTCCCCCCATTAGGATTCTATTACATATGCAATTGTAGGTTCAACCTGTCCCTTTCCCTGCCAGCAAACCC
CACCACCCTAAGAGAAATTTTAGCTTATATATGACGGTATATTTACAAAAAGAGAAAGAGAAAATCTGGTATTTGCAATGATCTGTGCCT

>78012_78012_1_RPS6KA3-SH3KBP1_RPS6KA3_chrX_20252876_ENST00000379565_SH3KBP1_chrX_19663593_ENST00000379698_length(amino acids)=465AA_BP=42
MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKE
GDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKE
RPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVV
SSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGG
GGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLR

--------------------------------------------------------------
>78012_78012_2_RPS6KA3-SH3KBP1_RPS6KA3_chrX_20252876_ENST00000379565_SH3KBP1_chrX_19663593_ENST00000379716_length(transcript)=4016nt_BP=334nt
AGGCGCGCGGCTTTCGGGCGGTCGGCGTCGGCGTCGAGCCCTCTCTGGGGCCGCCGCCGCTGCTGCTGCTGCTGCCGCTGCCGCTGCCGC
TGCCGCCGCCGCCGCCGCCGCCGCCGCTGCCGTGGGGCTCGGGCGGCGACGGAGCGGGGCCGGCCGTGGGGCGGGCGGGGAGGGAGGAGG
CGGTGAAGGCGGCGGGCCGGGGGGGAAGATGCCGCTGGCGCAGCTGGCGGACCCGTGGCAGAAGATGGCTGTGGAGAGCCCGTCCGACAG
CGCTGAGAATGGACAGCAAATTATGGATGAACCTATGGGAGAGGAGGAGATTAACCCACAAACTACTATTGGGAAGAAGTTACCTGCAAC
TACAGCAACTCCAGACTCATCAAAAACAGAAATGGACAGCAGGACAAAGAGCAAGGATTACTGCAAAGTAATATTTCCATATGAGGCACA
GAATGATGATGAATTGACAATCAAAGAAGGAGATATAGTCACTCTCATCAATAAGGACTGCATCGACGTAGGCTGGTGGGAAGGAGAGCT
GAACGGCAGACGAGGCGTGTTCCCCGATAACTTCGTGAAGTTACTTCCACCGGACTTTGAAAAGGAAGGGAATAGACCCAAGAAGCCACC
GCCTCCATCCGCTCCTGTCATCAAACAAGGGGCAGGCACCACTGAGAGAAAACATGAAATTAAAAAGATACCTCCTGAAAGACCAGAAAT
GCTTCCAAACAGAACAGAAGAAAAAGAAAGACCAGAGAGAGAGCCAAAACTGGATTTACAGAAGCCCTCCGTTCCTGCCATACCGCCAAA
AAAGCCTCGGCCACCTAAGACCAATTCTCTCAGCAGACCTGGCGCACTGCCCCCGAGAAGGCCGGAGAGACCGGTGGGTCCGCTGACACA
CACCAGGGGTGACAGTCCAAAGATTGACTTGGCCGGCAGTTCGCTATCTGGCATCCTGGACAAAGATCTCTCGGACCGCAGCAATGACAT
TGACTTAGAAGGTTTTGACTCCGTGGTATCATCTACTGAGAAACTCAGTCATCCGACCACAAGCAGACCAAAAGCTACAGGGAGGCGGCC
TCCGTCCCAGTCCCTCACATCTTCATCCCTTTCAAGCCCTGATATCTTCGACTCCCCAAGTCCCGAAGAGGATAAGGAGGAACACATTTC
ACTTGCGCACAGAGGAGTGGACGCGTCAAAGAAAACTTCCAAGACTGTTACCATATCCCAAGTGTCTGACAACAAAGCATCCCTGCCGCC
CAAGCCGGGGACCATGGCAGCAGGTGGCGGTGGGCCAGCCCCTCTGTCCTCAGCGGCGCCCTCCCCCCTGTCATCCTCTTTGGGAACAGC
TGGACACAGAGCCAACTCCCCGTCTCTGTTCGGCACGGAAGGAAAACCAAAGATGGAGCCTGCGGCCAGCAGCCAGGCGGCCGTGGAGGA
GCTAAGGACACAGGTCCGCGAGCTGAGGAGCATCATCGAGACCATGAAGGACCAGCAGAAACGAGAGATTAAACAGTTATTGTCTGAGTT
GGATGAAGAGAAGAAAATCCGGCTTCGGTTGCAGATGGAAGTGAACGACATAAAGAAAGCTCTACAATCAAAATGAATACTTGATCAATG
AAATGTCACATTATTCATCCTGAGTCCGAGACTCAAATTTTCTGCCCCAGCCAAAATAATCTTGTGCCAAAAGATTAAAGGTTTGCCTCA
AAATGTCCCTGTTTGAAAGATTAGCACAAAAGTCTTGATAGCACAACACAAATTCCATCCAAGAGGAGAATCTTCCCCAGGGTTTAGTCC
TGGGGCTGGCACTCGTTGTGACTTACACAGAGCAAAATTGTGCTAAAGGCTTTTCTACTCTGAGATCTCAATGCGAAATGAAAACTCAGG
CAGTTTAGTCCATAGTGGTACTATTTTGATGATATTTTCCATTAATAAAATGTAATTTCAGATTATTCGTTTACAAGCTTTATAATTTTA
TGATTTTTTAATCGTGTTTTGTCACAGACTTCCCTAGTGTTTGTACTACACGTAGTCAGAAGCGAGTGTCCTTTTCTTTTGCTTCAGGCT
AAGAGCTGCCTCGCTCTTTGTCCCCCCATTAGGATTCTATTACATATGCAATTGTAGGTTCAACCTGTCCCTTTCCCTGCCAGCAAACCC
CACCACCCTAAGAGAAATTTTAGCTTATATATGACGGTATATTTACAAAAAGAGAAAGAGAAAATCTGGTATTTGCAATGATCTGTGCCT
TCTTTTTACCACCCTCTTGATTGGAGCTTTTGTGATGCAGCTACCATGATTCAAAAAAATTAAAAATTAAAAAAAAAAAATCTGCCACTT
ATCCAAGTCCACTAGAGGCCACTGTCTTCAAAGCTTCTCTCACCCTAGCCAAAGGTCCTAAGAGGAGACAGCTGTGAAGTTGGGCGTGCT
CTGTGGTACCAGCTGTGACTTTTCTATTTCTCCTAGTTTTAGGTTGTTCATGAAACTAGAAATGTCATCCTGCTTGATTTTTCATCAGCC
AAGTTAAACCCCTGCTTTCTGTCCTTTGCACCTTTTGCGTGAACAGAATATGCATTATTAAAGCAAAAATAAATAAAAGTAAAATGCAAA
TGAAAACAAGGGAGGGAAAGTTGTATTATTTCCTGCACTGGGTTACCCGTGTGTGTTATCGTTTAAACTGTATTCACATAATGTCATTTG
CCTTGCTCACTTGTAACCCCTTCCTCAGGTCCAAGAGAATGGGAGGAGGGTCATGTTGAAGTGTAGCCACTGGAACTTTCTTGCATTTAT
GGAGTTGCTTTTTCTTTCCCAAGGAAACTGATGTTTGCCTGTCCGCTTTATCTTTGTAGTACATGAACAGTTCAGCCTTAGACTATGTAA
CTGTTTTCTCATCCTTAGCTGAAAATGAGGGGCCTACTGTATTGCGAGACTGTTCAGGGGTAGGGGTGGAGGGGGTGGTCCCTTAATGGC
CCCTGAAGATGTTGGATGTGTTTCTCAAAAGCTGCTTTGTCTCTTTCCTGAGTTTAATAGTGAAACTACTAAACATTAATAGATTTGCAC
AGCCACAAAGAATGAGAGTTGATAATACCGAAGAAGTGATGCAAAAACAAAAAATCACATTACTGATCATTGATAGTATTACAAATAAAT
GTCTCTTCCTTTCTCTTCCTCCCTTCCTCCCCCTGCCTTCCTCTTAACCTATGTGCTCATCCTTGCTACTTGAGGCTGTTATTTCCCTCC
GAGTATTTAAGGAGCCCAAACACCTTGGTCTTCCTGGGTGGGGGCATAATTAAGGGAAGGGAGTGTATAAGGAAGGAAACCTCATACCCT
CCATTCCCATCCCTGGATATATTGCCTTTTCAGCAGCCTCGGGTTCAGTGTGCTTGGGGTCAGGAGTGCCAGGTTCCCAAGAGCAGCGTA
AAACATCCCTGTACCCCTTGACAGTTATAAGCATTTCTGCGTTAAACTTGAAGATTCCAGAGATTCCCCACGACCTAATGATCTAAGAAT
GCAGATTGGATTCTTTGATGTTCAAATTTCTCATTTACTTATGAAAATCCCTAATTATATAGTTTTATATAATGTGTATACAGAGTAGGA
TTGTTGATGAAATTGAGCGGTTGGAACACCCTCATGGAACACTGGCAACATGGAATGTAGAGAGCTGATGTCTTCCCCCTCATAGAGGCC
ATTGGCTTCCTTTGTATAAGGAGAGGGAGAAGTGATTCTGGAAGGAGAAGTTGGTATGTCTAGCTTCATTGCGGCCCCTCGGGCTACCCA
GCAAGAGGATTCTGCATCAAGGAACTGGACGAGCCGCTACCCAAACTGCCACCATCTTTACTCTTTACAAAATGGACCCATCGAGAATGT
TGAAAAGCTTGGAAGTATCACTTTTGAAAAAAAAAAAAATTATTTTGCATTCAGCATGGACTCGACCAGGCATCTATGGAGATTATTTTT

>78012_78012_2_RPS6KA3-SH3KBP1_RPS6KA3_chrX_20252876_ENST00000379565_SH3KBP1_chrX_19663593_ENST00000379716_length(amino acids)=465AA_BP=42
MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKE
GDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKE
RPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVV
SSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGG
GGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLR

--------------------------------------------------------------
>78012_78012_3_RPS6KA3-SH3KBP1_RPS6KA3_chrX_20252876_ENST00000379565_SH3KBP1_chrX_19663593_ENST00000397821_length(transcript)=4048nt_BP=334nt
AGGCGCGCGGCTTTCGGGCGGTCGGCGTCGGCGTCGAGCCCTCTCTGGGGCCGCCGCCGCTGCTGCTGCTGCTGCCGCTGCCGCTGCCGC
TGCCGCCGCCGCCGCCGCCGCCGCCGCTGCCGTGGGGCTCGGGCGGCGACGGAGCGGGGCCGGCCGTGGGGCGGGCGGGGAGGGAGGAGG
CGGTGAAGGCGGCGGGCCGGGGGGGAAGATGCCGCTGGCGCAGCTGGCGGACCCGTGGCAGAAGATGGCTGTGGAGAGCCCGTCCGACAG
CGCTGAGAATGGACAGCAAATTATGGATGAACCTATGGGAGAGGAGGAGATTAACCCACAAACTACTATTGGGAAGAAGTTACCTGCAAC
TACAGCAACTCCAGACTCATCAAAAACAGAAATGGACAGCAGGACAAAGAGCAAGGATTACTGCAAAGTAATATTTCCATATGAGGCACA
GAATGATGATGAATTGACAATCAAAGAAGGAGATATAGTCACTCTCATCAATAAGGACTGCATCGACGTAGGCTGGTGGGAAGGAGAGCT
GAACGGCAGACGAGGCGTGTTCCCCGATAACTTCGTGAAGTTACTTCCACCGGACTTTGAAAAGGAAGGGAATAGACCCAAGAAGCCACC
GCCTCCATCCGCTCCTGTCATCAAACAAGGGGCAGGCACCACTGAGAGAAAACATGAAATTAAAAAGATACCTCCTGAAAGACCAGAAAT
GCTTCCAAACAGAACAGAAGAAAAAGAAAGACCAGAGAGAGAGCCAAAACTGGATTTACAGAAGCCCTCCGTTCCTGCCATACCGCCAAA
AAAGCCTCGGCCACCTAAGACCAATTCTCTCAGCAGACCTGGCGCACTGCCCCCGAGAAGGCCGGAGAGACCGGTGGGTCCGCTGACACA
CACCAGGGGTGACAGTCCAAAGATTGACTTGGCCGGCAGTTCGCTATCTGGCATCCTGGACAAAGATCTCTCGGACCGCAGCAATGACAT
TGACTTAGAAGGTTTTGACTCCGTGGTATCATCTACTGAGAAACTCAGTCATCCGACCACAAGCAGACCAAAAGCTACAGGGAGGCGGCC
TCCGTCCCAGTCCCTCACATCTTCATCCCTTTCAAGCCCTGATATCTTCGACTCCCCAAGTCCCGAAGAGGATAAGGAGGAACACATTTC
ACTTGCGCACAGAGGAGTGGACGCGTCAAAGAAAACTTCCAAGACTGTTACCATATCCCAAGTGTCTGACAACAAAGCATCCCTGCCGCC
CAAGCCGGGGACCATGGCAGCAGGTGGCGGTGGGCCAGCCCCTCTGTCCTCAGCGGCGCCCTCCCCCCTGTCATCCTCTTTGGGAACAGC
TGGACACAGAGCCAACTCCCCGTCTCTGTTCGGCACGGAAGGAAAACCAAAGATGGAGCCTGCGGCCAGCAGCCAGGCGGCCGTGGAGGA
GCTAAGGACACAGGTCCGCGAGCTGAGGAGCATCATCGAGACCATGAAGGACCAGCAGAAACGAGAGATTAAACAGTTATTGTCTGAGTT
GGATGAAGAGAAGAAAATCCGGCTTCGGTTGCAGATGGAAGTGAACGACATAAAGAAAGCTCTACAATCAAAATGAATACTTGATCAATG
AAATGTCACATTATTCATCCTGAGTCCGAGACTCAAATTTTCTGCCCCAGCCAAAATAATCTTGTGCCAAAAGATTAAAGGTTTGCCTCA
AAATGTCCCTGTTTGAAAGATTAGCACAAAAGTCTTGATAGCACAACACAAATTCCATCCAAGAGGAGAATCTTCCCCAGGGTTTAGTCC
TGGGGCTGGCACTCGTTGTGACTTACACAGAGCAAAATTGTGCTAAAGGCTTTTCTACTCTGAGATCTCAATGCGAAATGAAAACTCAGG
CAGTTTAGTCCATAGTGGTACTATTTTGATGATATTTTCCATTAATAAAATGTAATTTCAGATTATTCGTTTACAAGCTTTATAATTTTA
TGATTTTTTAATCGTGTTTTGTCACAGACTTCCCTAGTGTTTGTACTACACGTAGTCAGAAGCGAGTGTCCTTTTCTTTTGCTTCAGGCT
AAGAGCTGCCTCGCTCTTTGTCCCCCCATTAGGATTCTATTACATATGCAATTGTAGGTTCAACCTGTCCCTTTCCCTGCCAGCAAACCC
CACCACCCTAAGAGAAATTTTAGCTTATATATGACGGTATATTTACAAAAAGAGAAAGAGAAAATCTGGTATTTGCAATGATCTGTGCCT
TCTTTTTACCACCCTCTTGATTGGAGCTTTTGTGATGCAGCTACCATGATTCAAAAAAATTAAAAATTAAAAAAAAAAAATCTGCCACTT
ATCCAAGTCCACTAGAGGCCACTGTCTTCAAAGCTTCTCTCACCCTAGCCAAAGGTCCTAAGAGGAGACAGCTGTGAAGTTGGGCGTGCT
CTGTGGTACCAGCTGTGACTTTTCTATTTCTCCTAGTTTTAGGTTGTTCATGAAACTAGAAATGTCATCCTGCTTGATTTTTCATCAGCC
AAGTTAAACCCCTGCTTTCTGTCCTTTGCACCTTTTGCGTGAACAGAATATGCATTATTAAAGCAAAAATAAATAAAAGTAAAATGCAAA
TGAAAACAAGGGAGGGAAAGTTGTATTATTTCCTGCACTGGGTTACCCGTGTGTGTTATCGTTTAAACTGTATTCACATAATGTCATTTG
CCTTGCTCACTTGTAACCCCTTCCTCAGGTCCAAGAGAATGGGAGGAGGGTCATGTTGAAGTGTAGCCACTGGAACTTTCTTGCATTTAT
GGAGTTGCTTTTTCTTTCCCAAGGAAACTGATGTTTGCCTGTCCGCTTTATCTTTGTAGTACATGAACAGTTCAGCCTTAGACTATGTAA
CTGTTTTCTCATCCTTAGCTGAAAATGAGGGGCCTACTGTATTGCGAGACTGTTCAGGGGTAGGGGTGGAGGGGGTGGTCCCTTAATGGC
CCCTGAAGATGTTGGATGTGTTTCTCAAAAGCTGCTTTGTCTCTTTCCTGAGTTTAATAGTGAAACTACTAAACATTAATAGATTTGCAC
AGCCACAAAGAATGAGAGTTGATAATACCGAAGAAGTGATGCAAAAACAAAAAATCACATTACTGATCATTGATAGTATTACAAATAAAT
GTCTCTTCCTTTCTCTTCCTCCCTTCCTCCCCCTGCCTTCCTCTTAACCTATGTGCTCATCCTTGCTACTTGAGGCTGTTATTTCCCTCC
GAGTATTTAAGGAGCCCAAACACCTTGGTCTTCCTGGGTGGGGGCATAATTAAGGGAAGGGAGTGTATAAGGAAGGAAACCTCATACCCT
CCATTCCCATCCCTGGATATATTGCCTTTTCAGCAGCCTCGGGTTCAGTGTGCTTGGGGTCAGGAGTGCCAGGTTCCCAAGAGCAGCGTA
AAACATCCCTGTACCCCTTGACAGTTATAAGCATTTCTGCGTTAAACTTGAAGATTCCAGAGATTCCCCACGACCTAATGATCTAAGAAT
GCAGATTGGATTCTTTGATGTTCAAATTTCTCATTTACTTATGAAAATCCCTAATTATATAGTTTTATATAATGTGTATACAGAGTAGGA
TTGTTGATGAAATTGAGCGGTTGGAACACCCTCATGGAACACTGGCAACATGGAATGTAGAGAGCTGATGTCTTCCCCCTCATAGAGGCC
ATTGGCTTCCTTTGTATAAGGAGAGGGAGAAGTGATTCTGGAAGGAGAAGTTGGTATGTCTAGCTTCATTGCGGCCCCTCGGGCTACCCA
GCAAGAGGATTCTGCATCAAGGAACTGGACGAGCCGCTACCCAAACTGCCACCATCTTTACTCTTTACAAAATGGACCCATCGAGAATGT
TGAAAAGCTTGGAAGTATCACTTTTGAAAAAAAAAAAAATTATTTTGCATTCAGCATGGACTCGACCAGGCATCTATGGAGATTATTTTT

>78012_78012_3_RPS6KA3-SH3KBP1_RPS6KA3_chrX_20252876_ENST00000379565_SH3KBP1_chrX_19663593_ENST00000397821_length(amino acids)=465AA_BP=42
MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKE
GDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKE
RPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVV
SSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGG
GGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLR

--------------------------------------------------------------
>78012_78012_4_RPS6KA3-SH3KBP1_RPS6KA3_chrX_20252876_ENST00000540702_SH3KBP1_chrX_19663593_ENST00000379698_length(transcript)=2186nt_BP=190nt
AGGATTATATCTTTATCCTTGAAATTTAAAAACATTTGCCAGGACATGTCTTGGTGTTGATGATCTCTGTTGAACCTTCTCAGTCTCCAG
TCTCAGGATAAATGAGGAGCTGATTCTTAATCCTGTCACATTGAATGGACAGCAAATTATGGATGAACCTATGGGAGAGGAGGAGATTAA
CCCACAAACTACTATTGGGAAGAAGTTACCTGCAACTACAGCAACTCCAGACTCATCAAAAACAGAAATGGACAGCAGGACAAAGAGCAA
GGATTACTGCAAAGTAATATTTCCATATGAGGCACAGAATGATGATGAATTGACAATCAAAGAAGGAGATATAGTCACTCTCATCAATAA
GGACTGCATCGACGTAGGCTGGTGGGAAGGAGAGCTGAACGGCAGACGAGGCGTGTTCCCCGATAACTTCGTGAAGTTACTTCCACCGGA
CTTTGAAAAGGAAGGGAATAGACCCAAGAAGCCACCGCCTCCATCCGCTCCTGTCATCAAACAAGGGGCAGGCACCACTGAGAGAAAACA
TGAAATTAAAAAGATACCTCCTGAAAGACCAGAAATGCTTCCAAACAGAACAGAAGAAAAAGAAAGACCAGAGAGAGAGCCAAAACTGGA
TTTACAGAAGCCCTCCGTTCCTGCCATACCGCCAAAAAAGCCTCGGCCACCTAAGACCAATTCTCTCAGCAGACCTGGCGCACTGCCCCC
GAGAAGGCCGGAGAGACCGGTGGGTCCGCTGACACACACCAGGGGTGACAGTCCAAAGATTGACTTGGCCGGCAGTTCGCTATCTGGCAT
CCTGGACAAAGATCTCTCGGACCGCAGCAATGACATTGACTTAGAAGGTTTTGACTCCGTGGTATCATCTACTGAGAAACTCAGTCATCC
GACCACAAGCAGACCAAAAGCTACAGGGAGGCGGCCTCCGTCCCAGTCCCTCACATCTTCATCCCTTTCAAGCCCTGATATCTTCGACTC
CCCAAGTCCCGAAGAGGATAAGGAGGAACACATTTCACTTGCGCACAGAGGAGTGGACGCGTCAAAGAAAACTTCCAAGACTGTTACCAT
ATCCCAAGTGTCTGACAACAAAGCATCCCTGCCGCCCAAGCCGGGGACCATGGCAGCAGGTGGCGGTGGGCCAGCCCCTCTGTCCTCAGC
GGCGCCCTCCCCCCTGTCATCCTCTTTGGGAACAGCTGGACACAGAGCCAACTCCCCGTCTCTGTTCGGCACGGAAGGAAAACCAAAGAT
GGAGCCTGCGGCCAGCAGCCAGGCGGCCGTGGAGGAGCTAAGGACACAGGTCCGCGAGCTGAGGAGCATCATCGAGACCATGAAGGACCA
GCAGAAACGAGAGATTAAACAGTTATTGTCTGAGTTGGATGAAGAGAAGAAAATCCGGCTTCGGTTGCAGATGGAAGTGAACGACATAAA
GAAAGCTCTACAATCAAAATGAATACTTGATCAATGAAATGTCACATTATTCATCCTGAGTCCGAGACTCAAATTTTCTGCCCCAGCCAA
AATAATCTTGTGCCAAAAGATTAAAGGTTTGCCTCAAAATGTCCCTGTTTGAAAGATTAGCACAAAAGTCTTGATAGCACAACACAAATT
CCATCCAAGAGGAGAATCTTCCCCAGGGTTTAGTCCTGGGGCTGGCACTCGTTGTGACTTACACAGAGCAAAATTGTGCTAAAGGCTTTT
CTACTCTGAGATCTCAATGCGAAATGAAAACTCAGGCAGTTTAGTCCATAGTGGTACTATTTTGATGATATTTTCCATTAATAAAATGTA
ATTTCAGATTATTCGTTTACAAGCTTTATAATTTTATGATTTTTTAATCGTGTTTTGTCACAGACTTCCCTAGTGTTTGTACTACACGTA
GTCAGAAGCGAGTGTCCTTTTCTTTTGCTTCAGGCTAAGAGCTGCCTCGCTCTTTGTCCCCCCATTAGGATTCTATTACATATGCAATTG
TAGGTTCAACCTGTCCCTTTCCCTGCCAGCAAACCCCACCACCCTAAGAGAAATTTTAGCTTATATATGACGGTATATTTACAAAAAGAG
AAAGAGAAAATCTGGTATTTGCAATGATCTGTGCCTTCTTTTTACCACCCTCTTGATTGGAGCTTTTGTGATGCAGCTACCATGATTCAA

>78012_78012_4_RPS6KA3-SH3KBP1_RPS6KA3_chrX_20252876_ENST00000540702_SH3KBP1_chrX_19663593_ENST00000379698_length(amino acids)=450AA_BP=27
MILNPVTLNGQQIMDEPMGEEEINPQTTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVG
WWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSV
PAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPK
ATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLS
SSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK

--------------------------------------------------------------
>78012_78012_5_RPS6KA3-SH3KBP1_RPS6KA3_chrX_20252876_ENST00000540702_SH3KBP1_chrX_19663593_ENST00000379716_length(transcript)=3872nt_BP=190nt
AGGATTATATCTTTATCCTTGAAATTTAAAAACATTTGCCAGGACATGTCTTGGTGTTGATGATCTCTGTTGAACCTTCTCAGTCTCCAG
TCTCAGGATAAATGAGGAGCTGATTCTTAATCCTGTCACATTGAATGGACAGCAAATTATGGATGAACCTATGGGAGAGGAGGAGATTAA
CCCACAAACTACTATTGGGAAGAAGTTACCTGCAACTACAGCAACTCCAGACTCATCAAAAACAGAAATGGACAGCAGGACAAAGAGCAA
GGATTACTGCAAAGTAATATTTCCATATGAGGCACAGAATGATGATGAATTGACAATCAAAGAAGGAGATATAGTCACTCTCATCAATAA
GGACTGCATCGACGTAGGCTGGTGGGAAGGAGAGCTGAACGGCAGACGAGGCGTGTTCCCCGATAACTTCGTGAAGTTACTTCCACCGGA
CTTTGAAAAGGAAGGGAATAGACCCAAGAAGCCACCGCCTCCATCCGCTCCTGTCATCAAACAAGGGGCAGGCACCACTGAGAGAAAACA
TGAAATTAAAAAGATACCTCCTGAAAGACCAGAAATGCTTCCAAACAGAACAGAAGAAAAAGAAAGACCAGAGAGAGAGCCAAAACTGGA
TTTACAGAAGCCCTCCGTTCCTGCCATACCGCCAAAAAAGCCTCGGCCACCTAAGACCAATTCTCTCAGCAGACCTGGCGCACTGCCCCC
GAGAAGGCCGGAGAGACCGGTGGGTCCGCTGACACACACCAGGGGTGACAGTCCAAAGATTGACTTGGCCGGCAGTTCGCTATCTGGCAT
CCTGGACAAAGATCTCTCGGACCGCAGCAATGACATTGACTTAGAAGGTTTTGACTCCGTGGTATCATCTACTGAGAAACTCAGTCATCC
GACCACAAGCAGACCAAAAGCTACAGGGAGGCGGCCTCCGTCCCAGTCCCTCACATCTTCATCCCTTTCAAGCCCTGATATCTTCGACTC
CCCAAGTCCCGAAGAGGATAAGGAGGAACACATTTCACTTGCGCACAGAGGAGTGGACGCGTCAAAGAAAACTTCCAAGACTGTTACCAT
ATCCCAAGTGTCTGACAACAAAGCATCCCTGCCGCCCAAGCCGGGGACCATGGCAGCAGGTGGCGGTGGGCCAGCCCCTCTGTCCTCAGC
GGCGCCCTCCCCCCTGTCATCCTCTTTGGGAACAGCTGGACACAGAGCCAACTCCCCGTCTCTGTTCGGCACGGAAGGAAAACCAAAGAT
GGAGCCTGCGGCCAGCAGCCAGGCGGCCGTGGAGGAGCTAAGGACACAGGTCCGCGAGCTGAGGAGCATCATCGAGACCATGAAGGACCA
GCAGAAACGAGAGATTAAACAGTTATTGTCTGAGTTGGATGAAGAGAAGAAAATCCGGCTTCGGTTGCAGATGGAAGTGAACGACATAAA
GAAAGCTCTACAATCAAAATGAATACTTGATCAATGAAATGTCACATTATTCATCCTGAGTCCGAGACTCAAATTTTCTGCCCCAGCCAA
AATAATCTTGTGCCAAAAGATTAAAGGTTTGCCTCAAAATGTCCCTGTTTGAAAGATTAGCACAAAAGTCTTGATAGCACAACACAAATT
CCATCCAAGAGGAGAATCTTCCCCAGGGTTTAGTCCTGGGGCTGGCACTCGTTGTGACTTACACAGAGCAAAATTGTGCTAAAGGCTTTT
CTACTCTGAGATCTCAATGCGAAATGAAAACTCAGGCAGTTTAGTCCATAGTGGTACTATTTTGATGATATTTTCCATTAATAAAATGTA
ATTTCAGATTATTCGTTTACAAGCTTTATAATTTTATGATTTTTTAATCGTGTTTTGTCACAGACTTCCCTAGTGTTTGTACTACACGTA
GTCAGAAGCGAGTGTCCTTTTCTTTTGCTTCAGGCTAAGAGCTGCCTCGCTCTTTGTCCCCCCATTAGGATTCTATTACATATGCAATTG
TAGGTTCAACCTGTCCCTTTCCCTGCCAGCAAACCCCACCACCCTAAGAGAAATTTTAGCTTATATATGACGGTATATTTACAAAAAGAG
AAAGAGAAAATCTGGTATTTGCAATGATCTGTGCCTTCTTTTTACCACCCTCTTGATTGGAGCTTTTGTGATGCAGCTACCATGATTCAA
AAAAATTAAAAATTAAAAAAAAAAAATCTGCCACTTATCCAAGTCCACTAGAGGCCACTGTCTTCAAAGCTTCTCTCACCCTAGCCAAAG
GTCCTAAGAGGAGACAGCTGTGAAGTTGGGCGTGCTCTGTGGTACCAGCTGTGACTTTTCTATTTCTCCTAGTTTTAGGTTGTTCATGAA
ACTAGAAATGTCATCCTGCTTGATTTTTCATCAGCCAAGTTAAACCCCTGCTTTCTGTCCTTTGCACCTTTTGCGTGAACAGAATATGCA
TTATTAAAGCAAAAATAAATAAAAGTAAAATGCAAATGAAAACAAGGGAGGGAAAGTTGTATTATTTCCTGCACTGGGTTACCCGTGTGT
GTTATCGTTTAAACTGTATTCACATAATGTCATTTGCCTTGCTCACTTGTAACCCCTTCCTCAGGTCCAAGAGAATGGGAGGAGGGTCAT
GTTGAAGTGTAGCCACTGGAACTTTCTTGCATTTATGGAGTTGCTTTTTCTTTCCCAAGGAAACTGATGTTTGCCTGTCCGCTTTATCTT
TGTAGTACATGAACAGTTCAGCCTTAGACTATGTAACTGTTTTCTCATCCTTAGCTGAAAATGAGGGGCCTACTGTATTGCGAGACTGTT
CAGGGGTAGGGGTGGAGGGGGTGGTCCCTTAATGGCCCCTGAAGATGTTGGATGTGTTTCTCAAAAGCTGCTTTGTCTCTTTCCTGAGTT
TAATAGTGAAACTACTAAACATTAATAGATTTGCACAGCCACAAAGAATGAGAGTTGATAATACCGAAGAAGTGATGCAAAAACAAAAAA
TCACATTACTGATCATTGATAGTATTACAAATAAATGTCTCTTCCTTTCTCTTCCTCCCTTCCTCCCCCTGCCTTCCTCTTAACCTATGT
GCTCATCCTTGCTACTTGAGGCTGTTATTTCCCTCCGAGTATTTAAGGAGCCCAAACACCTTGGTCTTCCTGGGTGGGGGCATAATTAAG
GGAAGGGAGTGTATAAGGAAGGAAACCTCATACCCTCCATTCCCATCCCTGGATATATTGCCTTTTCAGCAGCCTCGGGTTCAGTGTGCT
TGGGGTCAGGAGTGCCAGGTTCCCAAGAGCAGCGTAAAACATCCCTGTACCCCTTGACAGTTATAAGCATTTCTGCGTTAAACTTGAAGA
TTCCAGAGATTCCCCACGACCTAATGATCTAAGAATGCAGATTGGATTCTTTGATGTTCAAATTTCTCATTTACTTATGAAAATCCCTAA
TTATATAGTTTTATATAATGTGTATACAGAGTAGGATTGTTGATGAAATTGAGCGGTTGGAACACCCTCATGGAACACTGGCAACATGGA
ATGTAGAGAGCTGATGTCTTCCCCCTCATAGAGGCCATTGGCTTCCTTTGTATAAGGAGAGGGAGAAGTGATTCTGGAAGGAGAAGTTGG
TATGTCTAGCTTCATTGCGGCCCCTCGGGCTACCCAGCAAGAGGATTCTGCATCAAGGAACTGGACGAGCCGCTACCCAAACTGCCACCA
TCTTTACTCTTTACAAAATGGACCCATCGAGAATGTTGAAAAGCTTGGAAGTATCACTTTTGAAAAAAAAAAAAATTATTTTGCATTCAG
CATGGACTCGACCAGGCATCTATGGAGATTATTTTTTTGCTTCATTTTATAAAGTTGTATTTAGAAAAGTCTTAAGTATTGTGCTTTGTA

>78012_78012_5_RPS6KA3-SH3KBP1_RPS6KA3_chrX_20252876_ENST00000540702_SH3KBP1_chrX_19663593_ENST00000379716_length(amino acids)=450AA_BP=27
MILNPVTLNGQQIMDEPMGEEEINPQTTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVG
WWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSV
PAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPK
ATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLS
SSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK

--------------------------------------------------------------
>78012_78012_6_RPS6KA3-SH3KBP1_RPS6KA3_chrX_20252876_ENST00000540702_SH3KBP1_chrX_19663593_ENST00000397821_length(transcript)=3904nt_BP=190nt
AGGATTATATCTTTATCCTTGAAATTTAAAAACATTTGCCAGGACATGTCTTGGTGTTGATGATCTCTGTTGAACCTTCTCAGTCTCCAG
TCTCAGGATAAATGAGGAGCTGATTCTTAATCCTGTCACATTGAATGGACAGCAAATTATGGATGAACCTATGGGAGAGGAGGAGATTAA
CCCACAAACTACTATTGGGAAGAAGTTACCTGCAACTACAGCAACTCCAGACTCATCAAAAACAGAAATGGACAGCAGGACAAAGAGCAA
GGATTACTGCAAAGTAATATTTCCATATGAGGCACAGAATGATGATGAATTGACAATCAAAGAAGGAGATATAGTCACTCTCATCAATAA
GGACTGCATCGACGTAGGCTGGTGGGAAGGAGAGCTGAACGGCAGACGAGGCGTGTTCCCCGATAACTTCGTGAAGTTACTTCCACCGGA
CTTTGAAAAGGAAGGGAATAGACCCAAGAAGCCACCGCCTCCATCCGCTCCTGTCATCAAACAAGGGGCAGGCACCACTGAGAGAAAACA
TGAAATTAAAAAGATACCTCCTGAAAGACCAGAAATGCTTCCAAACAGAACAGAAGAAAAAGAAAGACCAGAGAGAGAGCCAAAACTGGA
TTTACAGAAGCCCTCCGTTCCTGCCATACCGCCAAAAAAGCCTCGGCCACCTAAGACCAATTCTCTCAGCAGACCTGGCGCACTGCCCCC
GAGAAGGCCGGAGAGACCGGTGGGTCCGCTGACACACACCAGGGGTGACAGTCCAAAGATTGACTTGGCCGGCAGTTCGCTATCTGGCAT
CCTGGACAAAGATCTCTCGGACCGCAGCAATGACATTGACTTAGAAGGTTTTGACTCCGTGGTATCATCTACTGAGAAACTCAGTCATCC
GACCACAAGCAGACCAAAAGCTACAGGGAGGCGGCCTCCGTCCCAGTCCCTCACATCTTCATCCCTTTCAAGCCCTGATATCTTCGACTC
CCCAAGTCCCGAAGAGGATAAGGAGGAACACATTTCACTTGCGCACAGAGGAGTGGACGCGTCAAAGAAAACTTCCAAGACTGTTACCAT
ATCCCAAGTGTCTGACAACAAAGCATCCCTGCCGCCCAAGCCGGGGACCATGGCAGCAGGTGGCGGTGGGCCAGCCCCTCTGTCCTCAGC
GGCGCCCTCCCCCCTGTCATCCTCTTTGGGAACAGCTGGACACAGAGCCAACTCCCCGTCTCTGTTCGGCACGGAAGGAAAACCAAAGAT
GGAGCCTGCGGCCAGCAGCCAGGCGGCCGTGGAGGAGCTAAGGACACAGGTCCGCGAGCTGAGGAGCATCATCGAGACCATGAAGGACCA
GCAGAAACGAGAGATTAAACAGTTATTGTCTGAGTTGGATGAAGAGAAGAAAATCCGGCTTCGGTTGCAGATGGAAGTGAACGACATAAA
GAAAGCTCTACAATCAAAATGAATACTTGATCAATGAAATGTCACATTATTCATCCTGAGTCCGAGACTCAAATTTTCTGCCCCAGCCAA
AATAATCTTGTGCCAAAAGATTAAAGGTTTGCCTCAAAATGTCCCTGTTTGAAAGATTAGCACAAAAGTCTTGATAGCACAACACAAATT
CCATCCAAGAGGAGAATCTTCCCCAGGGTTTAGTCCTGGGGCTGGCACTCGTTGTGACTTACACAGAGCAAAATTGTGCTAAAGGCTTTT
CTACTCTGAGATCTCAATGCGAAATGAAAACTCAGGCAGTTTAGTCCATAGTGGTACTATTTTGATGATATTTTCCATTAATAAAATGTA
ATTTCAGATTATTCGTTTACAAGCTTTATAATTTTATGATTTTTTAATCGTGTTTTGTCACAGACTTCCCTAGTGTTTGTACTACACGTA
GTCAGAAGCGAGTGTCCTTTTCTTTTGCTTCAGGCTAAGAGCTGCCTCGCTCTTTGTCCCCCCATTAGGATTCTATTACATATGCAATTG
TAGGTTCAACCTGTCCCTTTCCCTGCCAGCAAACCCCACCACCCTAAGAGAAATTTTAGCTTATATATGACGGTATATTTACAAAAAGAG
AAAGAGAAAATCTGGTATTTGCAATGATCTGTGCCTTCTTTTTACCACCCTCTTGATTGGAGCTTTTGTGATGCAGCTACCATGATTCAA
AAAAATTAAAAATTAAAAAAAAAAAATCTGCCACTTATCCAAGTCCACTAGAGGCCACTGTCTTCAAAGCTTCTCTCACCCTAGCCAAAG
GTCCTAAGAGGAGACAGCTGTGAAGTTGGGCGTGCTCTGTGGTACCAGCTGTGACTTTTCTATTTCTCCTAGTTTTAGGTTGTTCATGAA
ACTAGAAATGTCATCCTGCTTGATTTTTCATCAGCCAAGTTAAACCCCTGCTTTCTGTCCTTTGCACCTTTTGCGTGAACAGAATATGCA
TTATTAAAGCAAAAATAAATAAAAGTAAAATGCAAATGAAAACAAGGGAGGGAAAGTTGTATTATTTCCTGCACTGGGTTACCCGTGTGT
GTTATCGTTTAAACTGTATTCACATAATGTCATTTGCCTTGCTCACTTGTAACCCCTTCCTCAGGTCCAAGAGAATGGGAGGAGGGTCAT
GTTGAAGTGTAGCCACTGGAACTTTCTTGCATTTATGGAGTTGCTTTTTCTTTCCCAAGGAAACTGATGTTTGCCTGTCCGCTTTATCTT
TGTAGTACATGAACAGTTCAGCCTTAGACTATGTAACTGTTTTCTCATCCTTAGCTGAAAATGAGGGGCCTACTGTATTGCGAGACTGTT
CAGGGGTAGGGGTGGAGGGGGTGGTCCCTTAATGGCCCCTGAAGATGTTGGATGTGTTTCTCAAAAGCTGCTTTGTCTCTTTCCTGAGTT
TAATAGTGAAACTACTAAACATTAATAGATTTGCACAGCCACAAAGAATGAGAGTTGATAATACCGAAGAAGTGATGCAAAAACAAAAAA
TCACATTACTGATCATTGATAGTATTACAAATAAATGTCTCTTCCTTTCTCTTCCTCCCTTCCTCCCCCTGCCTTCCTCTTAACCTATGT
GCTCATCCTTGCTACTTGAGGCTGTTATTTCCCTCCGAGTATTTAAGGAGCCCAAACACCTTGGTCTTCCTGGGTGGGGGCATAATTAAG
GGAAGGGAGTGTATAAGGAAGGAAACCTCATACCCTCCATTCCCATCCCTGGATATATTGCCTTTTCAGCAGCCTCGGGTTCAGTGTGCT
TGGGGTCAGGAGTGCCAGGTTCCCAAGAGCAGCGTAAAACATCCCTGTACCCCTTGACAGTTATAAGCATTTCTGCGTTAAACTTGAAGA
TTCCAGAGATTCCCCACGACCTAATGATCTAAGAATGCAGATTGGATTCTTTGATGTTCAAATTTCTCATTTACTTATGAAAATCCCTAA
TTATATAGTTTTATATAATGTGTATACAGAGTAGGATTGTTGATGAAATTGAGCGGTTGGAACACCCTCATGGAACACTGGCAACATGGA
ATGTAGAGAGCTGATGTCTTCCCCCTCATAGAGGCCATTGGCTTCCTTTGTATAAGGAGAGGGAGAAGTGATTCTGGAAGGAGAAGTTGG
TATGTCTAGCTTCATTGCGGCCCCTCGGGCTACCCAGCAAGAGGATTCTGCATCAAGGAACTGGACGAGCCGCTACCCAAACTGCCACCA
TCTTTACTCTTTACAAAATGGACCCATCGAGAATGTTGAAAAGCTTGGAAGTATCACTTTTGAAAAAAAAAAAAATTATTTTGCATTCAG
CATGGACTCGACCAGGCATCTATGGAGATTATTTTTTTGCTTCATTTTATAAAGTTGTATTTAGAAAAGTCTTAAGTATTGTGCTTTGTA

>78012_78012_6_RPS6KA3-SH3KBP1_RPS6KA3_chrX_20252876_ENST00000540702_SH3KBP1_chrX_19663593_ENST00000397821_length(amino acids)=450AA_BP=27
MILNPVTLNGQQIMDEPMGEEEINPQTTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVG
WWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSV
PAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPK
ATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLS
SSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK

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Fusion Gene PPI Analysis for RPS6KA3-SH3KBP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RPS6KA3-SH3KBP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RPS6KA3-SH3KBP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource