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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RPS6KB1-SNF8 (FusionGDB2 ID:78041)

Fusion Gene Summary for RPS6KB1-SNF8

check button Fusion gene summary
Fusion gene informationFusion gene name: RPS6KB1-SNF8
Fusion gene ID: 78041
HgeneTgene
Gene symbol

RPS6KB1

SNF8

Gene ID

6198

11267

Gene nameribosomal protein S6 kinase B1SNF8 subunit of ESCRT-II
SynonymsPS6K|S6K|S6K-beta-1|S6K1|STK14A|p70 S6KA|p70(S6K)-alpha|p70-S6K|p70-alphaDot3|EAP30|VPS22
Cytomap

17q23.1

17q21.32

Type of geneprotein-codingprotein-coding
Descriptionribosomal protein S6 kinase beta-1p70 S6 kinase, alpharibosomal protein S6 kinase Iribosomal protein S6 kinase, 70kDa, polypeptide 1serine/threonine kinase 14 alphaserine/threonine-protein kinase 14Avacuolar-sorting protein SNF8EAP30 subunit of ELL complexELL-associated protein of 30 kDaESCRT-II complex subunit VPS22SNF8, ESCRT-II complex subunit, homolog
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000225577, ENST00000406116, 
ENST00000443572, ENST00000393021, 
ENST00000587061, 		ENST00000514089, 
ENST00000290330, ENST00000502492, 
Fusion gene scores* DoF score14 X 17 X 14=33326 X 5 X 5=150
# samples 4710
** MAII scorelog2(47/3332*10)=-2.82565573880055
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/150*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPS6KB1 [Title/Abstract] AND SNF8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRPS6KB1(57970687)-SNF8(47021338), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPS6KB1

GO:0031667

response to nutrient levels

29750193

HgeneRPS6KB1

GO:0031929

TOR signaling

12150926

HgeneRPS6KB1

GO:0071363

cellular response to growth factor stimulus

17936702

TgeneSNF8

GO:0006357

regulation of transcription by RNA polymerase II

10419521


check buttonFusion gene breakpoints across RPS6KB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SNF8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AXX000001RPS6KB1chr17

57970687

+SNF8chr17

47021338

-


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Fusion Gene ORF analysis for RPS6KB1-SNF8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000225577ENST00000514089RPS6KB1chr17

57970687

+SNF8chr17

47021338

-
5CDS-intronENST00000406116ENST00000514089RPS6KB1chr17

57970687

+SNF8chr17

47021338

-
5CDS-intronENST00000443572ENST00000514089RPS6KB1chr17

57970687

+SNF8chr17

47021338

-
5UTR-3CDSENST00000393021ENST00000290330RPS6KB1chr17

57970687

+SNF8chr17

47021338

-
5UTR-3CDSENST00000393021ENST00000502492RPS6KB1chr17

57970687

+SNF8chr17

47021338

-
5UTR-intronENST00000393021ENST00000514089RPS6KB1chr17

57970687

+SNF8chr17

47021338

-
In-frameENST00000225577ENST00000290330RPS6KB1chr17

57970687

+SNF8chr17

47021338

-
In-frameENST00000225577ENST00000502492RPS6KB1chr17

57970687

+SNF8chr17

47021338

-
In-frameENST00000406116ENST00000290330RPS6KB1chr17

57970687

+SNF8chr17

47021338

-
In-frameENST00000406116ENST00000502492RPS6KB1chr17

57970687

+SNF8chr17

47021338

-
In-frameENST00000443572ENST00000290330RPS6KB1chr17

57970687

+SNF8chr17

47021338

-
In-frameENST00000443572ENST00000502492RPS6KB1chr17

57970687

+SNF8chr17

47021338

-
intron-3CDSENST00000587061ENST00000290330RPS6KB1chr17

57970687

+SNF8chr17

47021338

-
intron-3CDSENST00000587061ENST00000502492RPS6KB1chr17

57970687

+SNF8chr17

47021338

-
intron-intronENST00000587061ENST00000514089RPS6KB1chr17

57970687

+SNF8chr17

47021338

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000443572RPS6KB1chr1757970687+ENST00000502492SNF8chr1747021338-207819655918287
ENST00000443572RPS6KB1chr1757970687+ENST00000290330SNF8chr1747021338-101719655915286
ENST00000406116RPS6KB1chr1757970687+ENST00000502492SNF8chr1747021338-206318140903287
ENST00000406116RPS6KB1chr1757970687+ENST00000290330SNF8chr1747021338-100218140900286
ENST00000225577RPS6KB1chr1757970687+ENST00000502492SNF8chr1747021338-204416221884287
ENST00000225577RPS6KB1chr1757970687+ENST00000290330SNF8chr1747021338-98316221881286

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000443572ENST00000502492RPS6KB1chr1757970687+SNF8chr1747021338-0.001019190.9989808
ENST00000443572ENST00000290330RPS6KB1chr1757970687+SNF8chr1747021338-0.0020223660.9979777
ENST00000406116ENST00000502492RPS6KB1chr1757970687+SNF8chr1747021338-0.000992260.99900776
ENST00000406116ENST00000290330RPS6KB1chr1757970687+SNF8chr1747021338-0.0020205970.99797946
ENST00000225577ENST00000502492RPS6KB1chr1757970687+SNF8chr1747021338-0.0011267150.9988733
ENST00000225577ENST00000290330RPS6KB1chr1757970687+SNF8chr1747021338-0.0021566070.9978434

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Fusion Genomic Features for RPS6KB1-SNF8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RPS6KB1-SNF8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:57970687/chr17:47021338)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRPS6KB1chr17:57970687chr17:47021338ENST00000225577+11528_3247526.0MotifNote=TOS motif
TgeneSNF8chr17:57970687chr17:47021338ENST000002903300827_5318258.0Coiled coilOntology_term=ECO:0000255
TgeneSNF8chr17:57970687chr17:47021338ENST000005024920827_5318259.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRPS6KB1chr17:57970687chr17:47021338ENST00000225577+115353_42347526.0DomainAGC-kinase C-terminal
HgeneRPS6KB1chr17:57970687chr17:47021338ENST00000225577+11591_35247526.0DomainProtein kinase
HgeneRPS6KB1chr17:57970687chr17:47021338ENST00000225577+11597_10547526.0Nucleotide bindingATP
HgeneRPS6KB1chr17:57970687chr17:47021338ENST00000225577+115424_52547526.0RegionNote=Autoinhibitory domain


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Fusion Gene Sequence for RPS6KB1-SNF8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>78041_78041_1_RPS6KB1-SNF8_RPS6KB1_chr17_57970687_ENST00000225577_SNF8_chr17_47021338_ENST00000290330_length(transcript)=983nt_BP=162nt
GGCTGCGGCGGGTCCGGGCCCATGAGGCGACGAAGGAGGCGGGACGGCTTTTACCCAGCCCCGGACTTCCGAGACAGGGAAGCTGAGGAC
ATGGCAGGAGTGTTTGACATAGACCTGGACCAGCCAGAGGACGCGGGCTCTGAGGATGAGCTGGAGGAGGGGGCCAAGTATAAGGAGCGA
GGGACGGTCTTGGCTGAGGACCAGCTAGCCCAGATGTCAAAGCAGTTGGACATGTTCAAGACCAACCTGGAGGAATTTGCCAGCAAACAC
AAGCAGGAGATCCGGAAGAATCCTGAGTTCCGTGTGCAGTTCCAGGACATGTGTGCAACCATTGGCGTGGATCCGCTGGCCTCTGGAAAA
GGATTTTGGTCTGAGATGCTGGGCGTGGGGGACTTCTATTACGAACTAGGTGTCCAAATTATCGAAGTGTGCCTGGCGCTGAAGCATCGG
AATGGAGGTCTGATAACTTTGGAGGAACTACATCAACAGGTGTTGAAGGGAAGGGGCAAGTTCGCCCAGGATGTCAGTCAAGATGACCTG
ATCAGAGCCATCAAGAAACTAAAGGCACTTGGCACTGGCTTCGGCATCATCCCTGTGGGCGGCACTTACCTCATTCAGTCTGTTCCAGCT
GAGCTCAATATGGATCACACCGTGGTGCTGCAGCTGGCAGAGAATGGCTACGTGACTGTCAGTGAGATCAAAGCCAGTCTTAAATGGGAG
ACCGAGCGAGCGCGGCAAGTGCTGGAACACCTGCTGAAGGAAGGGTTGGCGTGGCTGGACTTACAGGCCCCAGGGGAGGCCCACTACTGG
CTGCCAGCTCTCTTCACTGACCTCTACTCCCAGGAGATTACAGCTGAGGAGGCCAGAGAAGCCCTCCCCTGACTGCATGTGGAAGGGCAC

>78041_78041_1_RPS6KB1-SNF8_RPS6KB1_chr17_57970687_ENST00000225577_SNF8_chr17_47021338_ENST00000290330_length(amino acids)=286AA_BP=47
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGAKYKERGTVLAEDQLAQMSKQLDMFKTNLEEFASKHKQEIRKN
PEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITLEELHQQVLKGRGKFAQDVSQDDLIRAIKKL
KALGTGFGIIPVGGTYLIQSVPAELNMDHTVVLQLAENGYVTVSEIKASLKWETERARQVLEHLLKEGLAWLDLQAPGEAHYWLPALFTD

--------------------------------------------------------------
>78041_78041_2_RPS6KB1-SNF8_RPS6KB1_chr17_57970687_ENST00000225577_SNF8_chr17_47021338_ENST00000502492_length(transcript)=2044nt_BP=162nt
GGCTGCGGCGGGTCCGGGCCCATGAGGCGACGAAGGAGGCGGGACGGCTTTTACCCAGCCCCGGACTTCCGAGACAGGGAAGCTGAGGAC
ATGGCAGGAGTGTTTGACATAGACCTGGACCAGCCAGAGGACGCGGGCTCTGAGGATGAGCTGGAGGAGGGGGCCAAGTATAAGGAGCGA
GGGACGGTCTTGGCTGAGGACCAGCTAGCCCAGATGTCAAAGCAGTTGGACATGTTCAAGACCAACCTGGAGGAATTTGCCAGCAAACAC
AAGCAGGAGATCCGGAAGAATCCTGAGTTCCGTGTGCAGTTCCAGGACATGTGTGCAACCATTGGCGTGGATCCGCTGGCCTCTGGAAAA
GGATTTTGGTCTGAGATGCTGGGCGTGGGGGACTTCTATTACGAACTAGGTGTCCAAATTATCGAAGTGTGCCTGGCGCTGAAGCATCGG
AATGGAGGTCTGATAACTTTGGAGGAACTACATCAACAGGTGTTGAAGGGAAGGGGCAAGTTCGCCCAGGATGTCAGTCAAGATGACCTG
ATCAGAGCCATCAAGAAACTAAAGGCACTTGGCACTGGCTTCGGCATCATCCCTGTGGGCGGCACTTACCTCATTCAGTCTGTTCCAGCT
GAGCTCAATATGGATCACACCGTGGTGCTGCAGCTGGCAGAGAAGAATGGCTACGTGACTGTCAGTGAGATCAAAGCCAGTCTTAAATGG
GAGACCGAGCGAGCGCGGCAAGTGCTGGAACACCTGCTGAAGGAAGGGTTGGCGTGGCTGGACTTACAGGCCCCAGGGGAGGCCCACTAC
TGGCTGCCAGCTCTCTTCACTGACCTCTACTCCCAGGAGATTACAGCTGAGGAGGCCAGAGAAGCCCTCCCCTGACTGCATGTGGAAGGG
CACACAGCAGCAGGCAGGGAGGAGGCGGAGGTGGCAAATAAACCTGGGCAATTTTGTTTATACAAAAAATAGAAAAAAAGTTCCAAGTTT
TTCTTTCTTCCCTCATTCTTTTATTTTTGAAAAGTGCCTTCACGTTGCATTTTTATTGGAGGAAAACCTCGCTCGTTCAGTAAGCATAAT
CTGATTAACACAGAGAACGGCAAGCACATATAAAATGATTTTTGTAGGTCATCTGCAAGTTCATGGAAGAGCTGGGCCTAGAATGTGGGT
TGTTTCCTGGCCTGTCTAGTCTTTGTAGCTGTGAGACATAGATTACAGCCTATGCTAATTCAAACCTTTTAAATAAAATGTTCCTTATCT
CAAACTAGCTGGTCCTAATGGACCAGTAAATAATATTCACTTTCAGTCTCTTCTGGCTTCCTCTGTAGAGGCTCTAGGTTATGACAGAGT
TAGCTGTGAGTATGAAGGAAATAGAAGTCAATGTCCAATCGTGGCTAAATTGGAGGAAAGAAAACAATGGAATCTGAGGGGAATCAAACA
ATAGTTAGGGAATGTTCTATTTTCTTAAATTCCCTACTAGCTTTCTCACCCTCCTGTAGTGATTGCCAGGTCCCTCTAGCCTCAGTAGTG
GGAAAGGGAGTCATTTACTGAACACCTACCCTGTGCCATTTTACATACAGCTCACTTAAATTTCACCAAGTAGGCAGCCTTCAACATCAC
AGGTGATTCAATCAAAGTAATTTGCCAGGGGCCGCCAGCTTCAGCCGAGCTAAAGCTGGTGCCTAGGCCTATTAACCCGAGCCCATGCCT
TCATGTATCACTGCATAGTACAGAATGGCAGCACATACTGTGTGTAGACATTTTTCTACACACGTGGTCAGCCAAGAGTAAAAGCCTCTG
CATCAGAAAGCAAGAATCTCCTATAGCAAGTAGAAGTGGTGATGAGGGAAGAGGCCAGAGTTGTTTAAGGCTCCCAAAGTCCTTATGGTC
TAAAGGCTAAGATCCTAAAAGTGCTAGTTTAGTACTGGAAATCTGAAAACTCAATGGTTTTTCCATACTGAGACCCTTCCTTTAGCAGGA

>78041_78041_2_RPS6KB1-SNF8_RPS6KB1_chr17_57970687_ENST00000225577_SNF8_chr17_47021338_ENST00000502492_length(amino acids)=287AA_BP=47
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGAKYKERGTVLAEDQLAQMSKQLDMFKTNLEEFASKHKQEIRKN
PEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITLEELHQQVLKGRGKFAQDVSQDDLIRAIKKL
KALGTGFGIIPVGGTYLIQSVPAELNMDHTVVLQLAEKNGYVTVSEIKASLKWETERARQVLEHLLKEGLAWLDLQAPGEAHYWLPALFT

--------------------------------------------------------------
>78041_78041_3_RPS6KB1-SNF8_RPS6KB1_chr17_57970687_ENST00000406116_SNF8_chr17_47021338_ENST00000290330_length(transcript)=1002nt_BP=181nt
TGGCGGCAGCGGCTGTGGTGGCTGCGGCGGGTCCGGGCCCATGAGGCGACGAAGGAGGCGGGACGGCTTTTACCCAGCCCCGGACTTCCG
AGACAGGGAAGCTGAGGACATGGCAGGAGTGTTTGACATAGACCTGGACCAGCCAGAGGACGCGGGCTCTGAGGATGAGCTGGAGGAGGG
GGCCAAGTATAAGGAGCGAGGGACGGTCTTGGCTGAGGACCAGCTAGCCCAGATGTCAAAGCAGTTGGACATGTTCAAGACCAACCTGGA
GGAATTTGCCAGCAAACACAAGCAGGAGATCCGGAAGAATCCTGAGTTCCGTGTGCAGTTCCAGGACATGTGTGCAACCATTGGCGTGGA
TCCGCTGGCCTCTGGAAAAGGATTTTGGTCTGAGATGCTGGGCGTGGGGGACTTCTATTACGAACTAGGTGTCCAAATTATCGAAGTGTG
CCTGGCGCTGAAGCATCGGAATGGAGGTCTGATAACTTTGGAGGAACTACATCAACAGGTGTTGAAGGGAAGGGGCAAGTTCGCCCAGGA
TGTCAGTCAAGATGACCTGATCAGAGCCATCAAGAAACTAAAGGCACTTGGCACTGGCTTCGGCATCATCCCTGTGGGCGGCACTTACCT
CATTCAGTCTGTTCCAGCTGAGCTCAATATGGATCACACCGTGGTGCTGCAGCTGGCAGAGAATGGCTACGTGACTGTCAGTGAGATCAA
AGCCAGTCTTAAATGGGAGACCGAGCGAGCGCGGCAAGTGCTGGAACACCTGCTGAAGGAAGGGTTGGCGTGGCTGGACTTACAGGCCCC
AGGGGAGGCCCACTACTGGCTGCCAGCTCTCTTCACTGACCTCTACTCCCAGGAGATTACAGCTGAGGAGGCCAGAGAAGCCCTCCCCTG
ACTGCATGTGGAAGGGCACACAGCAGCAGGCAGGGAGGAGGCGGAGGTGGCAAATAAACCTGGGCAATTTTGTTTATACAAAAAATAGAA

>78041_78041_3_RPS6KB1-SNF8_RPS6KB1_chr17_57970687_ENST00000406116_SNF8_chr17_47021338_ENST00000290330_length(amino acids)=286AA_BP=47
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGAKYKERGTVLAEDQLAQMSKQLDMFKTNLEEFASKHKQEIRKN
PEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITLEELHQQVLKGRGKFAQDVSQDDLIRAIKKL
KALGTGFGIIPVGGTYLIQSVPAELNMDHTVVLQLAENGYVTVSEIKASLKWETERARQVLEHLLKEGLAWLDLQAPGEAHYWLPALFTD

--------------------------------------------------------------
>78041_78041_4_RPS6KB1-SNF8_RPS6KB1_chr17_57970687_ENST00000406116_SNF8_chr17_47021338_ENST00000502492_length(transcript)=2063nt_BP=181nt
TGGCGGCAGCGGCTGTGGTGGCTGCGGCGGGTCCGGGCCCATGAGGCGACGAAGGAGGCGGGACGGCTTTTACCCAGCCCCGGACTTCCG
AGACAGGGAAGCTGAGGACATGGCAGGAGTGTTTGACATAGACCTGGACCAGCCAGAGGACGCGGGCTCTGAGGATGAGCTGGAGGAGGG
GGCCAAGTATAAGGAGCGAGGGACGGTCTTGGCTGAGGACCAGCTAGCCCAGATGTCAAAGCAGTTGGACATGTTCAAGACCAACCTGGA
GGAATTTGCCAGCAAACACAAGCAGGAGATCCGGAAGAATCCTGAGTTCCGTGTGCAGTTCCAGGACATGTGTGCAACCATTGGCGTGGA
TCCGCTGGCCTCTGGAAAAGGATTTTGGTCTGAGATGCTGGGCGTGGGGGACTTCTATTACGAACTAGGTGTCCAAATTATCGAAGTGTG
CCTGGCGCTGAAGCATCGGAATGGAGGTCTGATAACTTTGGAGGAACTACATCAACAGGTGTTGAAGGGAAGGGGCAAGTTCGCCCAGGA
TGTCAGTCAAGATGACCTGATCAGAGCCATCAAGAAACTAAAGGCACTTGGCACTGGCTTCGGCATCATCCCTGTGGGCGGCACTTACCT
CATTCAGTCTGTTCCAGCTGAGCTCAATATGGATCACACCGTGGTGCTGCAGCTGGCAGAGAAGAATGGCTACGTGACTGTCAGTGAGAT
CAAAGCCAGTCTTAAATGGGAGACCGAGCGAGCGCGGCAAGTGCTGGAACACCTGCTGAAGGAAGGGTTGGCGTGGCTGGACTTACAGGC
CCCAGGGGAGGCCCACTACTGGCTGCCAGCTCTCTTCACTGACCTCTACTCCCAGGAGATTACAGCTGAGGAGGCCAGAGAAGCCCTCCC
CTGACTGCATGTGGAAGGGCACACAGCAGCAGGCAGGGAGGAGGCGGAGGTGGCAAATAAACCTGGGCAATTTTGTTTATACAAAAAATA
GAAAAAAAGTTCCAAGTTTTTCTTTCTTCCCTCATTCTTTTATTTTTGAAAAGTGCCTTCACGTTGCATTTTTATTGGAGGAAAACCTCG
CTCGTTCAGTAAGCATAATCTGATTAACACAGAGAACGGCAAGCACATATAAAATGATTTTTGTAGGTCATCTGCAAGTTCATGGAAGAG
CTGGGCCTAGAATGTGGGTTGTTTCCTGGCCTGTCTAGTCTTTGTAGCTGTGAGACATAGATTACAGCCTATGCTAATTCAAACCTTTTA
AATAAAATGTTCCTTATCTCAAACTAGCTGGTCCTAATGGACCAGTAAATAATATTCACTTTCAGTCTCTTCTGGCTTCCTCTGTAGAGG
CTCTAGGTTATGACAGAGTTAGCTGTGAGTATGAAGGAAATAGAAGTCAATGTCCAATCGTGGCTAAATTGGAGGAAAGAAAACAATGGA
ATCTGAGGGGAATCAAACAATAGTTAGGGAATGTTCTATTTTCTTAAATTCCCTACTAGCTTTCTCACCCTCCTGTAGTGATTGCCAGGT
CCCTCTAGCCTCAGTAGTGGGAAAGGGAGTCATTTACTGAACACCTACCCTGTGCCATTTTACATACAGCTCACTTAAATTTCACCAAGT
AGGCAGCCTTCAACATCACAGGTGATTCAATCAAAGTAATTTGCCAGGGGCCGCCAGCTTCAGCCGAGCTAAAGCTGGTGCCTAGGCCTA
TTAACCCGAGCCCATGCCTTCATGTATCACTGCATAGTACAGAATGGCAGCACATACTGTGTGTAGACATTTTTCTACACACGTGGTCAG
CCAAGAGTAAAAGCCTCTGCATCAGAAAGCAAGAATCTCCTATAGCAAGTAGAAGTGGTGATGAGGGAAGAGGCCAGAGTTGTTTAAGGC
TCCCAAAGTCCTTATGGTCTAAAGGCTAAGATCCTAAAAGTGCTAGTTTAGTACTGGAAATCTGAAAACTCAATGGTTTTTCCATACTGA

>78041_78041_4_RPS6KB1-SNF8_RPS6KB1_chr17_57970687_ENST00000406116_SNF8_chr17_47021338_ENST00000502492_length(amino acids)=287AA_BP=47
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGAKYKERGTVLAEDQLAQMSKQLDMFKTNLEEFASKHKQEIRKN
PEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITLEELHQQVLKGRGKFAQDVSQDDLIRAIKKL
KALGTGFGIIPVGGTYLIQSVPAELNMDHTVVLQLAEKNGYVTVSEIKASLKWETERARQVLEHLLKEGLAWLDLQAPGEAHYWLPALFT

--------------------------------------------------------------
>78041_78041_5_RPS6KB1-SNF8_RPS6KB1_chr17_57970687_ENST00000443572_SNF8_chr17_47021338_ENST00000290330_length(transcript)=1017nt_BP=196nt
CTAAGCAGCCGGTGATGGCGGCAGCGGCTGTGGTGGCTGCGGCGGGTCCGGGCCCATGAGGCGACGAAGGAGGCGGGACGGCTTTTACCC
AGCCCCGGACTTCCGAGACAGGGAAGCTGAGGACATGGCAGGAGTGTTTGACATAGACCTGGACCAGCCAGAGGACGCGGGCTCTGAGGA
TGAGCTGGAGGAGGGGGCCAAGTATAAGGAGCGAGGGACGGTCTTGGCTGAGGACCAGCTAGCCCAGATGTCAAAGCAGTTGGACATGTT
CAAGACCAACCTGGAGGAATTTGCCAGCAAACACAAGCAGGAGATCCGGAAGAATCCTGAGTTCCGTGTGCAGTTCCAGGACATGTGTGC
AACCATTGGCGTGGATCCGCTGGCCTCTGGAAAAGGATTTTGGTCTGAGATGCTGGGCGTGGGGGACTTCTATTACGAACTAGGTGTCCA
AATTATCGAAGTGTGCCTGGCGCTGAAGCATCGGAATGGAGGTCTGATAACTTTGGAGGAACTACATCAACAGGTGTTGAAGGGAAGGGG
CAAGTTCGCCCAGGATGTCAGTCAAGATGACCTGATCAGAGCCATCAAGAAACTAAAGGCACTTGGCACTGGCTTCGGCATCATCCCTGT
GGGCGGCACTTACCTCATTCAGTCTGTTCCAGCTGAGCTCAATATGGATCACACCGTGGTGCTGCAGCTGGCAGAGAATGGCTACGTGAC
TGTCAGTGAGATCAAAGCCAGTCTTAAATGGGAGACCGAGCGAGCGCGGCAAGTGCTGGAACACCTGCTGAAGGAAGGGTTGGCGTGGCT
GGACTTACAGGCCCCAGGGGAGGCCCACTACTGGCTGCCAGCTCTCTTCACTGACCTCTACTCCCAGGAGATTACAGCTGAGGAGGCCAG
AGAAGCCCTCCCCTGACTGCATGTGGAAGGGCACACAGCAGCAGGCAGGGAGGAGGCGGAGGTGGCAAATAAACCTGGGCAATTTTGTTT

>78041_78041_5_RPS6KB1-SNF8_RPS6KB1_chr17_57970687_ENST00000443572_SNF8_chr17_47021338_ENST00000290330_length(amino acids)=286AA_BP=47
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGAKYKERGTVLAEDQLAQMSKQLDMFKTNLEEFASKHKQEIRKN
PEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITLEELHQQVLKGRGKFAQDVSQDDLIRAIKKL
KALGTGFGIIPVGGTYLIQSVPAELNMDHTVVLQLAENGYVTVSEIKASLKWETERARQVLEHLLKEGLAWLDLQAPGEAHYWLPALFTD

--------------------------------------------------------------
>78041_78041_6_RPS6KB1-SNF8_RPS6KB1_chr17_57970687_ENST00000443572_SNF8_chr17_47021338_ENST00000502492_length(transcript)=2078nt_BP=196nt
CTAAGCAGCCGGTGATGGCGGCAGCGGCTGTGGTGGCTGCGGCGGGTCCGGGCCCATGAGGCGACGAAGGAGGCGGGACGGCTTTTACCC
AGCCCCGGACTTCCGAGACAGGGAAGCTGAGGACATGGCAGGAGTGTTTGACATAGACCTGGACCAGCCAGAGGACGCGGGCTCTGAGGA
TGAGCTGGAGGAGGGGGCCAAGTATAAGGAGCGAGGGACGGTCTTGGCTGAGGACCAGCTAGCCCAGATGTCAAAGCAGTTGGACATGTT
CAAGACCAACCTGGAGGAATTTGCCAGCAAACACAAGCAGGAGATCCGGAAGAATCCTGAGTTCCGTGTGCAGTTCCAGGACATGTGTGC
AACCATTGGCGTGGATCCGCTGGCCTCTGGAAAAGGATTTTGGTCTGAGATGCTGGGCGTGGGGGACTTCTATTACGAACTAGGTGTCCA
AATTATCGAAGTGTGCCTGGCGCTGAAGCATCGGAATGGAGGTCTGATAACTTTGGAGGAACTACATCAACAGGTGTTGAAGGGAAGGGG
CAAGTTCGCCCAGGATGTCAGTCAAGATGACCTGATCAGAGCCATCAAGAAACTAAAGGCACTTGGCACTGGCTTCGGCATCATCCCTGT
GGGCGGCACTTACCTCATTCAGTCTGTTCCAGCTGAGCTCAATATGGATCACACCGTGGTGCTGCAGCTGGCAGAGAAGAATGGCTACGT
GACTGTCAGTGAGATCAAAGCCAGTCTTAAATGGGAGACCGAGCGAGCGCGGCAAGTGCTGGAACACCTGCTGAAGGAAGGGTTGGCGTG
GCTGGACTTACAGGCCCCAGGGGAGGCCCACTACTGGCTGCCAGCTCTCTTCACTGACCTCTACTCCCAGGAGATTACAGCTGAGGAGGC
CAGAGAAGCCCTCCCCTGACTGCATGTGGAAGGGCACACAGCAGCAGGCAGGGAGGAGGCGGAGGTGGCAAATAAACCTGGGCAATTTTG
TTTATACAAAAAATAGAAAAAAAGTTCCAAGTTTTTCTTTCTTCCCTCATTCTTTTATTTTTGAAAAGTGCCTTCACGTTGCATTTTTAT
TGGAGGAAAACCTCGCTCGTTCAGTAAGCATAATCTGATTAACACAGAGAACGGCAAGCACATATAAAATGATTTTTGTAGGTCATCTGC
AAGTTCATGGAAGAGCTGGGCCTAGAATGTGGGTTGTTTCCTGGCCTGTCTAGTCTTTGTAGCTGTGAGACATAGATTACAGCCTATGCT
AATTCAAACCTTTTAAATAAAATGTTCCTTATCTCAAACTAGCTGGTCCTAATGGACCAGTAAATAATATTCACTTTCAGTCTCTTCTGG
CTTCCTCTGTAGAGGCTCTAGGTTATGACAGAGTTAGCTGTGAGTATGAAGGAAATAGAAGTCAATGTCCAATCGTGGCTAAATTGGAGG
AAAGAAAACAATGGAATCTGAGGGGAATCAAACAATAGTTAGGGAATGTTCTATTTTCTTAAATTCCCTACTAGCTTTCTCACCCTCCTG
TAGTGATTGCCAGGTCCCTCTAGCCTCAGTAGTGGGAAAGGGAGTCATTTACTGAACACCTACCCTGTGCCATTTTACATACAGCTCACT
TAAATTTCACCAAGTAGGCAGCCTTCAACATCACAGGTGATTCAATCAAAGTAATTTGCCAGGGGCCGCCAGCTTCAGCCGAGCTAAAGC
TGGTGCCTAGGCCTATTAACCCGAGCCCATGCCTTCATGTATCACTGCATAGTACAGAATGGCAGCACATACTGTGTGTAGACATTTTTC
TACACACGTGGTCAGCCAAGAGTAAAAGCCTCTGCATCAGAAAGCAAGAATCTCCTATAGCAAGTAGAAGTGGTGATGAGGGAAGAGGCC
AGAGTTGTTTAAGGCTCCCAAAGTCCTTATGGTCTAAAGGCTAAGATCCTAAAAGTGCTAGTTTAGTACTGGAAATCTGAAAACTCAATG
GTTTTTCCATACTGAGACCCTTCCTTTAGCAGGATATAGCCTGGGCCCATCTCTTCCTCTGCCTATCCTTGTAGGACATGCTCACTCCAA

>78041_78041_6_RPS6KB1-SNF8_RPS6KB1_chr17_57970687_ENST00000443572_SNF8_chr17_47021338_ENST00000502492_length(amino acids)=287AA_BP=47
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGAKYKERGTVLAEDQLAQMSKQLDMFKTNLEEFASKHKQEIRKN
PEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITLEELHQQVLKGRGKFAQDVSQDDLIRAIKKL
KALGTGFGIIPVGGTYLIQSVPAELNMDHTVVLQLAEKNGYVTVSEIKASLKWETERARQVLEHLLKEGLAWLDLQAPGEAHYWLPALFT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RPS6KB1-SNF8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RPS6KB1-SNF8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RPS6KB1-SNF8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource