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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RPS6-RPL23 (FusionGDB2 ID:78091)

Fusion Gene Summary for RPS6-RPL23

check button Fusion gene summary
Fusion gene informationFusion gene name: RPS6-RPL23
Fusion gene ID: 78091
HgeneTgene
Gene symbol

RPS6

RPL23

Gene ID

6194

9349

Gene nameribosomal protein S6ribosomal protein L23
SynonymsS6L23|rpL17
Cytomap

9p22.1

17q12

Type of geneprotein-codingprotein-coding
Description40S ribosomal protein S6phosphoprotein NP33small ribosomal subunit protein eS660S ribosomal protein L2360S ribosomal protein L17large ribosomal subunit protein uL14ribosomal protein L17
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000315377, ENST00000380384, 
ENST00000380394, ENST00000380381, 
ENST00000498815, 		ENST00000245857, 
ENST00000577407, ENST00000394333, 
ENST00000479035, ENST00000394332, 
Fusion gene scores* DoF score28 X 23 X 7=450824 X 19 X 8=3648
# samples 3225
** MAII scorelog2(32/4508*10)=-3.81634370528486
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(25/3648*10)=-3.86710572950266
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPS6 [Title/Abstract] AND RPL23 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRPS6(19378366)-RPL23(37009358), # samples:1
Anticipated loss of major functional domain due to fusion event.RPS6-RPL23 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
RPS6-RPL23 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
RPS6-RPL23 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
RPS6-RPL23 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPS6

GO:0031929

TOR signaling

16428328

HgeneRPS6

GO:0043065

positive regulation of apoptotic process

18362888

TgeneRPL23

GO:0032986

protein-DNA complex disassembly

19160485

TgeneRPL23

GO:1904667

negative regulation of ubiquitin protein ligase activity

15314173

TgeneRPL23

GO:2000059

negative regulation of ubiquitin-dependent protein catabolic process

15314173


check buttonFusion gene breakpoints across RPS6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RPL23 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-DI-A2QT-01ARPS6chr9

19378366

-RPL23chr17

37009358

-


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Fusion Gene ORF analysis for RPS6-RPL23

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000315377ENST00000245857RPS6chr9

19378366

-RPL23chr17

37009358

-
5CDS-5UTRENST00000315377ENST00000577407RPS6chr9

19378366

-RPL23chr17

37009358

-
5CDS-5UTRENST00000380384ENST00000245857RPS6chr9

19378366

-RPL23chr17

37009358

-
5CDS-5UTRENST00000380384ENST00000577407RPS6chr9

19378366

-RPL23chr17

37009358

-
5CDS-5UTRENST00000380394ENST00000245857RPS6chr9

19378366

-RPL23chr17

37009358

-
5CDS-5UTRENST00000380394ENST00000577407RPS6chr9

19378366

-RPL23chr17

37009358

-
Frame-shiftENST00000315377ENST00000394333RPS6chr9

19378366

-RPL23chr17

37009358

-
Frame-shiftENST00000315377ENST00000479035RPS6chr9

19378366

-RPL23chr17

37009358

-
Frame-shiftENST00000380384ENST00000394332RPS6chr9

19378366

-RPL23chr17

37009358

-
Frame-shiftENST00000380394ENST00000394332RPS6chr9

19378366

-RPL23chr17

37009358

-
In-frameENST00000315377ENST00000394332RPS6chr9

19378366

-RPL23chr17

37009358

-
In-frameENST00000380384ENST00000394333RPS6chr9

19378366

-RPL23chr17

37009358

-
In-frameENST00000380384ENST00000479035RPS6chr9

19378366

-RPL23chr17

37009358

-
In-frameENST00000380394ENST00000394333RPS6chr9

19378366

-RPL23chr17

37009358

-
In-frameENST00000380394ENST00000479035RPS6chr9

19378366

-RPL23chr17

37009358

-
intron-3CDSENST00000380381ENST00000394332RPS6chr9

19378366

-RPL23chr17

37009358

-
intron-3CDSENST00000380381ENST00000394333RPS6chr9

19378366

-RPL23chr17

37009358

-
intron-3CDSENST00000380381ENST00000479035RPS6chr9

19378366

-RPL23chr17

37009358

-
intron-3CDSENST00000498815ENST00000394332RPS6chr9

19378366

-RPL23chr17

37009358

-
intron-3CDSENST00000498815ENST00000394333RPS6chr9

19378366

-RPL23chr17

37009358

-
intron-3CDSENST00000498815ENST00000479035RPS6chr9

19378366

-RPL23chr17

37009358

-
intron-5UTRENST00000380381ENST00000245857RPS6chr9

19378366

-RPL23chr17

37009358

-
intron-5UTRENST00000380381ENST00000577407RPS6chr9

19378366

-RPL23chr17

37009358

-
intron-5UTRENST00000498815ENST00000245857RPS6chr9

19378366

-RPL23chr17

37009358

-
intron-5UTRENST00000498815ENST00000577407RPS6chr9

19378366

-RPL23chr17

37009358

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000380394RPS6chr919378366-ENST00000394333RPL23chr1737009358-96155559886275
ENST00000380394RPS6chr919378366-ENST00000479035RPL23chr1737009358-323055559964301
ENST00000380384RPS6chr919378366-ENST00000394333RPL23chr1737009358-148410785881409273
ENST00000380384RPS6chr919378366-ENST00000479035RPL23chr1737009358-375310785881487299
ENST00000315377RPS6chr919378366-ENST00000394332RPL23chr1737009358-12016011111010299

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000380394ENST00000394333RPS6chr919378366-RPL23chr1737009358-0.0013611450.9986388
ENST00000380394ENST00000479035RPS6chr919378366-RPL23chr1737009358-0.0005406310.9994593
ENST00000380384ENST00000394333RPS6chr919378366-RPL23chr1737009358-0.0045751670.9954248
ENST00000380384ENST00000479035RPS6chr919378366-RPL23chr1737009358-0.0008663310.99913365
ENST00000315377ENST00000394332RPS6chr919378366-RPL23chr1737009358-0.0012185020.9987815

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Fusion Genomic Features for RPS6-RPL23


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RPS6-RPL23


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:19378366/chr17:37009358)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for RPS6-RPL23


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>78091_78091_1_RPS6-RPL23_RPS6_chr9_19378366_ENST00000315377_RPL23_chr17_37009358_ENST00000394332_length(transcript)=1201nt_BP=601nt
AAGATGAAGGTAGGTGATGGTGGCGAGTGTTAGACTGGGTTTGGGGAACGTGAATCGAGTCCCAGAACGCGGCATTGCCTCAGTTCCAGC
ACTCCAGGATCCTGGCTTTAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTCGT
ACTTTCTATGAGAAGCGTATGGCCACAGAAGTTGCTGCTGACGCTCTGGGTGAAGAATGGAAGGGTTATGTGGTCCGAATCAGTGGTGGG
AACGACAAACAAGGTTTCCCCATGAAGCAGGGTGTCTTGACCCATGGCCGTGTCCGCCTGCTACTGAGTAAGGGGCATTCCTGTTACAGA
CCAAGGAGAACTGGAGAAAGAAAGAGAAAATCAGTTCGTGGTTGCATTGTGGATGCAAATCTGAGCGTTCTCAACTTGGTTATTGTAAAA
AAAGGAGAGAAGGATATTCCTGGACTGACTGATACTACAGTGCCTCGCCGCCTGGGCCCCAAAAGAGCTAGCAGAATCCGCAAACTTTTC
AATCTCTCTAAAGAAGATGATGTCCGCCAGTATGTTGTAAGAAAGCCCTTAAATAAAGAAGGACGTGGTGGGTCCTCTGGTGCGAAATTC
CGGATTTCCTTGGGTCTTCCGGTAGGAGCTGTAATCAATTGTGCTGACAACACAGGAGCCAAAAACCTGTATATCATCTCCGTGAAGGGG
ATCAAGGGACGGCTGAACAGACTTCCCGCTGCTGGTGTGGGTGACATGGTGATGGCCACAGTCAAGAAAGGCAAACCAGAGCTCAGAAAA
AAGGTACATCCAGCAGTGGTCATTCGACAACGAAAGTCATACCGTAGAAAAGATGGCGTGTTTCTTTATTTTGAAGATAATGCAGGAGTC
ATAGTGAACAATAAAGGCGAGATGAAAGGTTCTGCCATTACAGGACCAGTAGCAAAGGAGTGTGCAGACTTGTGGCCCCGGATTGCATCC
AATGCTGGCAGCATTGCATGATTCTCCAGTATATTTGCTGGAGTGCAGTAACACCACTGAAGCTCACTGTAACTTTGAACTGCTGGACTT
GGAATCCTCCTGCTGTGGCCTTCAAAGGGCTGCAATTACAAGTGTGAGCCACTGCATCCCACCTCACATTTTATTCTTTGGAGATTTTTT

>78091_78091_1_RPS6-RPL23_RPS6_chr9_19378366_ENST00000315377_RPL23_chr17_37009358_ENST00000394332_length(amino acids)=299AA_BP=163
MNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGER
KRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGRGGSSGAKFRISLGLP
VGAVINCADNTGAKNLYIISVKGIKGRLNRLPAAGVGDMVMATVKKGKPELRKKVHPAVVIRQRKSYRRKDGVFLYFEDNAGVIVNNKGE

--------------------------------------------------------------
>78091_78091_2_RPS6-RPL23_RPS6_chr9_19378366_ENST00000380384_RPL23_chr17_37009358_ENST00000394333_length(transcript)=1484nt_BP=1078nt
GCTGCTTCAAGATGAAGGTAGGTGATGGTGGCGAGTGTTAGACTGGGTTTGGGGAACGTGAATCGAGTCCCAGAACGCGGCATTGCCTCA
GTTCCAGCACTCCAGGATCCTGGCTTTAGGTGGAGAAGGGTCTCAAGTAGGAGAAGGCTCGCCTTTCTGGGGCATGGAGCTTTTTGGCCG
AACGGATGGCAGGCGATTGCGGCTGGAGCCGCGGCGGGCCGGGAGCGCCATGGTGGCGTCCCCGCGCCCAGCCGGGACGGATGCGGCGTG
TTGCCCAGTTTGCGGCAGGCCTGTGGTGCGGCTCTTGACCCCGGCTTTCTTGCTTCGGGAGGGTGAACGGCTGCGGAGTGCCCTCGCCCC
CAGAGTCATTCCGCGGGGCTTGAGGGGAAAACGTCCTGCTGAGTGCGGCGCTTCTTGACTGCTACTCTGCTTTCACGTGCTTTTAGTGAG
TACAGTCGGCATCTTATATTTCCTGCTTGTGTGGAGGCAACATGAAAGGCTTTTTGCAGTGGAATTAACTTTGTAGATGGCTCTACAATT
ACCTGTATAGATAGTTTCGTAAACTATTTCCCCCCTTTTAATCCTTAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATT
GAAGTGGACGATGAACGCAAACTTCGTACTTTCTATGAGAAGCGTATGGCCACAGAAGTTGCTGCTGACGCTCTGGGTGAAGAATGGAAG
GGTTATGTGGTCCGAATCAGTGGTGGGAACGACAAACAAGGTTTCCCCATGAAGCAGGGTGTCTTGACCCATGGCCGTGTCCGCCTGCTA
CTGAGTAAGGGGCATTCCTGTTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAAATCAGTTCGTGGTTGCATTGTGGATGCAAATCTG
AGCGTTCTCAACTTGGTTATTGTAAAAAAAGGAGAGAAGGATATTCCTGGACTGACTGATACTACAGTGCCTCGCCGCCTGGGCCCCAAA
AGAGCTAGCAGAATCCGCAAACTTTTCAATCTCTCTAAAGAAGATGATGTCCGCCAGTATGTTGTAAGAAAGCCCTTAAATAAAGAAGGA
CGTGGTGGGTCCTCTGGTGCGAAATTCCGGATTTCCTTGGGTCTTCCGGTAGGAGCTGTAATCAATTGTGCTGACAACACAGGAGCCAAA
AACCTGTATATCATCTCCGTGAAGGGGATCAAGGGACGGCTGAACAGACTTCCCGCTGCTGGTGTGGGTGACATGGTGATGGCCACAGTC
AAGAAAGGCAAACCAGAGCTCAGAAAAAAGGTCTTGCTCTGTCACACAGGCTGGAGTGCAGTAACACCACTGAAGCTCACTGTAACTTTG
AACTGCTGGACTTGGAATCCTCCTGCTGTGGCCTTCAAAGGGCTGCAATTACAAGTGTGAGCCACTGCATCCCACCTCACATTTTATTCT

>78091_78091_2_RPS6-RPL23_RPS6_chr9_19378366_ENST00000380384_RPL23_chr17_37009358_ENST00000394333_length(amino acids)=273AA_BP=163
MNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGER
KRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGRGGSSGAKFRISLGLP
VGAVINCADNTGAKNLYIISVKGIKGRLNRLPAAGVGDMVMATVKKGKPELRKKVLLCHTGWSAVTPLKLTVTLNCWTWNPPAVAFKGLQ

--------------------------------------------------------------
>78091_78091_3_RPS6-RPL23_RPS6_chr9_19378366_ENST00000380384_RPL23_chr17_37009358_ENST00000479035_length(transcript)=3753nt_BP=1078nt
GCTGCTTCAAGATGAAGGTAGGTGATGGTGGCGAGTGTTAGACTGGGTTTGGGGAACGTGAATCGAGTCCCAGAACGCGGCATTGCCTCA
GTTCCAGCACTCCAGGATCCTGGCTTTAGGTGGAGAAGGGTCTCAAGTAGGAGAAGGCTCGCCTTTCTGGGGCATGGAGCTTTTTGGCCG
AACGGATGGCAGGCGATTGCGGCTGGAGCCGCGGCGGGCCGGGAGCGCCATGGTGGCGTCCCCGCGCCCAGCCGGGACGGATGCGGCGTG
TTGCCCAGTTTGCGGCAGGCCTGTGGTGCGGCTCTTGACCCCGGCTTTCTTGCTTCGGGAGGGTGAACGGCTGCGGAGTGCCCTCGCCCC
CAGAGTCATTCCGCGGGGCTTGAGGGGAAAACGTCCTGCTGAGTGCGGCGCTTCTTGACTGCTACTCTGCTTTCACGTGCTTTTAGTGAG
TACAGTCGGCATCTTATATTTCCTGCTTGTGTGGAGGCAACATGAAAGGCTTTTTGCAGTGGAATTAACTTTGTAGATGGCTCTACAATT
ACCTGTATAGATAGTTTCGTAAACTATTTCCCCCCTTTTAATCCTTAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATT
GAAGTGGACGATGAACGCAAACTTCGTACTTTCTATGAGAAGCGTATGGCCACAGAAGTTGCTGCTGACGCTCTGGGTGAAGAATGGAAG
GGTTATGTGGTCCGAATCAGTGGTGGGAACGACAAACAAGGTTTCCCCATGAAGCAGGGTGTCTTGACCCATGGCCGTGTCCGCCTGCTA
CTGAGTAAGGGGCATTCCTGTTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAAATCAGTTCGTGGTTGCATTGTGGATGCAAATCTG
AGCGTTCTCAACTTGGTTATTGTAAAAAAAGGAGAGAAGGATATTCCTGGACTGACTGATACTACAGTGCCTCGCCGCCTGGGCCCCAAA
AGAGCTAGCAGAATCCGCAAACTTTTCAATCTCTCTAAAGAAGATGATGTCCGCCAGTATGTTGTAAGAAAGCCCTTAAATAAAGAAGGA
CGTGGTGGGTCCTCTGGTGCGAAATTCCGGATTTCCTTGGGTCTTCCGGTAGGAGCTGTAATCAATTGTGCTGACAACACAGGAGCCAAA
AACCTGTATATCATCTCCGTGAAGGGGATCAAGGGACGGCTGAACAGACTTCCCGCTGCTGGTGTGGGTGACATGGTGATGGCCACAGTC
AAGAAAGGCAAACCAGAGCTCAGAAAAAAGGTACATCCAGCAGTGGTCATTCGACAACGAAAGTCATACCGTAGAAAAGATGGCGTGTTT
CTTTATTTTGAAGATAATGCAGGAGTCATAGTGAACAATAAAGGCGAGATGAAAGGTTCTGCCATTACAGGACCAGTAGCAAAGGAGTGT
GCAGACTTGTGGCCCCGGATTGCATCCAATGCTGGCAGCATTGCATGATTCTCCAGTATATTTGTAAAAAATAAAAAAAAAAACTAAACC
CATTAAAAAGTATTTGTTTGCAGTGCTTGTCTCCCTGTTCACTTCCAGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTAAGTAGCTGGG
ATTACAGGCACCTGCCGTCATGCCTGGCTAGTTTTTGTATTTTTGGTGGAGACAGGGTTTCACCATGTTTGCCAAACGACTCAAACTCCT
GATCTCAAGTGATCTGCCCACCCAGGCCTCTACAGTGTTTTTGACATACCCTGACCATCACTTTTCTGAAATGGAAACTCTGGGCATTTT
TTTTTTAAAGCAATCCTTGCTTTTTTGTGAGTTTGCAGACTTTCAGCATCTTCCAATTGCTGTATTTACAATTTTGGCCTCAAAAAGTAT
TATTTGGGTTTTGAGTCCCAAAAATAATAGTAGATACTGCTCAATGACTGGCTATACATGGTAGCTTCTCCTGGAGTGAGGAAGGCATTC
AAATGGCTGGGCGCGGTAGCTGGCACCTGTAATCCCAACACTTTCGGAGGCCAAGGCAGGCAGATCATGAGGTCAGGAGTTCAAGACCAG
GCTGACCAACGTGGTGAAACCTCCTCTTTTCTAAAAATACAAAAATTAGCTGGGCGTGGTGGCGCACCGCCTGTAATCTCAGCTACTGAG
AGAATCGCTTGAACCTGGGAGGTGGAGTTTGCAGCGAGTCGAGATTGCACCATTGTACTCCATCCAGCCTGGGCAACGGAGCAAGATTCC
GTTCCCGCCCCCGCCCCAAAAAAAGGCATTGAAGTTAAGATAGACTATATAGTTAGATCCTGGACACACACATGGATTTTGAGGAATGAT
GTGAGTTTGTTTATGTATGTACATTTTAGCAGTTAACAGATTTGGAGTAAATTGAATATTTATAAAACAACAGTAATTGCCATGTAGGTT
TACTGTCATAGTGGAAGATGATTAAGTTGATGGTACCTACAGGTATTTTGCTATGAAAATGTTTTGACAAACAGGATGATCGTGTAATTT
ATGTTCCAAGCTCTAGTTTGAGAATGGAAGAATGTGGTAAATTTTTGCCAACTGAACAGGCATAAAGCGCTGATAATAAGGGACTTGGCC
TTAAGGTAGGAGGTTGTTAGCATTTCTTTCTAAACGTGTAAGAGTTTATTTAGGTGACACCCAGCGTTTTGGAAAAATGGGTGTTTGTTT
AGAACAATAATTTGGAGGGAAGTGGACTAAACAGGGTTTTTAGATTAAGGTTTGTGTTTATGTATCTGTATCTGCAAATACTCAGCCATA
AATGTTTCTACCTGTAAGTTGGGTATAATACAAGCTCCACTTGGTATCAAAAAGGACTACCCTTAGTGTCTTCCATGACTAGTTATGGAA
TGTACCAGACCTAGAGAGGAGTTGTTCTAACCTGGAGCTTTTGAAAATGTTTCCGGTCCATACCCTAGACCAATTAAGTCAGACTGCAGA
ATAGGACTCAGACATCAGAATTGTGAAGCTCCCAGGAGATGTCAAGGTATACCCAAGACTGAGAACCAGTACCCTGTCTAGACTGAACCA
GGCTTGGTTTTAGAAGTATTAAATCTCGCCTGGGTACGGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATCA
TCTGAGGTCAGGAGAGTGAGACCAGCCTGTCCAACATGTTGAAACCCCATCTCTACTATACAAAATTAGCCAGGCATGGTGGTGCATGCT
GTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCCGGAGATGGAGGTTGCAGTGAGCTGAGGTCGCACGATTGTGC
TCCAGCCTGGGCAACCAGTGAAACTCTGGGGGGAAAGAAAAAAAATGTATTAAATCTCTAGTTTTAGAGAGTTACACCATAACATCCCTG
AGTATGGTCAATTTCAAGTCAGCTTTAGTGTGACAAGCCCCTAGGCCCACCATTTATGTCTTTATATATTATGGCAATATATGATCCTTA
TATATTAACCACTAATCGCTGCTGTTTTTGAATGTTATCTTTTCTGAGGCAGTCTTGCTCTGTCACACAGGCTGGAGTGCAGTAACACCA
CTGAAGCTCACTGTAACTTTGAACTGCTGGACTTGGAATCCTCCTGCTGTGGCCTTCAAAGGGCTGCAATTACAAGTGTGAGCCACTGCA

>78091_78091_3_RPS6-RPL23_RPS6_chr9_19378366_ENST00000380384_RPL23_chr17_37009358_ENST00000479035_length(amino acids)=299AA_BP=163
MNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGER
KRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGRGGSSGAKFRISLGLP
VGAVINCADNTGAKNLYIISVKGIKGRLNRLPAAGVGDMVMATVKKGKPELRKKVHPAVVIRQRKSYRRKDGVFLYFEDNAGVIVNNKGE

--------------------------------------------------------------
>78091_78091_4_RPS6-RPL23_RPS6_chr9_19378366_ENST00000380394_RPL23_chr17_37009358_ENST00000394333_length(transcript)=961nt_BP=555nt
GCTAAGCGGAAGTTGGCCCTCTTTTCCGTGGCGCCTCGGAGGCGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTG
GCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTCGTACTTTCTATGAGAAGCGTATGGCCACAGAAGTTGCTGCTGACGCTC
TGGGTGAAGAATGGAAGGGTTATGTGGTCCGAATCAGTGGTGGGAACGACAAACAAGGTTTCCCCATGAAGCAGGGTGTCTTGACCCATG
GCCGTGTCCGCCTGCTACTGAGTAAGGGGCATTCCTGTTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAAATCAGTTCGTGGTTGCA
TTGTGGATGCAAATCTGAGCGTTCTCAACTTGGTTATTGTAAAAAAAGGAGAGAAGGATATTCCTGGACTGACTGATACTACAGTGCCTC
GCCGCCTGGGCCCCAAAAGAGCTAGCAGAATCCGCAAACTTTTCAATCTCTCTAAAGAAGATGATGTCCGCCAGTATGTTGTAAGAAAGC
CCTTAAATAAAGAAGGACGTGGTGGGTCCTCTGGTGCGAAATTCCGGATTTCCTTGGGTCTTCCGGTAGGAGCTGTAATCAATTGTGCTG
ACAACACAGGAGCCAAAAACCTGTATATCATCTCCGTGAAGGGGATCAAGGGACGGCTGAACAGACTTCCCGCTGCTGGTGTGGGTGACA
TGGTGATGGCCACAGTCAAGAAAGGCAAACCAGAGCTCAGAAAAAAGGTCTTGCTCTGTCACACAGGCTGGAGTGCAGTAACACCACTGA
AGCTCACTGTAACTTTGAACTGCTGGACTTGGAATCCTCCTGCTGTGGCCTTCAAAGGGCTGCAATTACAAGTGTGAGCCACTGCATCCC

>78091_78091_4_RPS6-RPL23_RPS6_chr9_19378366_ENST00000380394_RPL23_chr17_37009358_ENST00000394333_length(amino acids)=275AA_BP=165
MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTG
ERKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGRGGSSGAKFRISLG
LPVGAVINCADNTGAKNLYIISVKGIKGRLNRLPAAGVGDMVMATVKKGKPELRKKVLLCHTGWSAVTPLKLTVTLNCWTWNPPAVAFKG

--------------------------------------------------------------
>78091_78091_5_RPS6-RPL23_RPS6_chr9_19378366_ENST00000380394_RPL23_chr17_37009358_ENST00000479035_length(transcript)=3230nt_BP=555nt
GCTAAGCGGAAGTTGGCCCTCTTTTCCGTGGCGCCTCGGAGGCGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTG
GCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTCGTACTTTCTATGAGAAGCGTATGGCCACAGAAGTTGCTGCTGACGCTC
TGGGTGAAGAATGGAAGGGTTATGTGGTCCGAATCAGTGGTGGGAACGACAAACAAGGTTTCCCCATGAAGCAGGGTGTCTTGACCCATG
GCCGTGTCCGCCTGCTACTGAGTAAGGGGCATTCCTGTTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAAATCAGTTCGTGGTTGCA
TTGTGGATGCAAATCTGAGCGTTCTCAACTTGGTTATTGTAAAAAAAGGAGAGAAGGATATTCCTGGACTGACTGATACTACAGTGCCTC
GCCGCCTGGGCCCCAAAAGAGCTAGCAGAATCCGCAAACTTTTCAATCTCTCTAAAGAAGATGATGTCCGCCAGTATGTTGTAAGAAAGC
CCTTAAATAAAGAAGGACGTGGTGGGTCCTCTGGTGCGAAATTCCGGATTTCCTTGGGTCTTCCGGTAGGAGCTGTAATCAATTGTGCTG
ACAACACAGGAGCCAAAAACCTGTATATCATCTCCGTGAAGGGGATCAAGGGACGGCTGAACAGACTTCCCGCTGCTGGTGTGGGTGACA
TGGTGATGGCCACAGTCAAGAAAGGCAAACCAGAGCTCAGAAAAAAGGTACATCCAGCAGTGGTCATTCGACAACGAAAGTCATACCGTA
GAAAAGATGGCGTGTTTCTTTATTTTGAAGATAATGCAGGAGTCATAGTGAACAATAAAGGCGAGATGAAAGGTTCTGCCATTACAGGAC
CAGTAGCAAAGGAGTGTGCAGACTTGTGGCCCCGGATTGCATCCAATGCTGGCAGCATTGCATGATTCTCCAGTATATTTGTAAAAAATA
AAAAAAAAAACTAAACCCATTAAAAAGTATTTGTTTGCAGTGCTTGTCTCCCTGTTCACTTCCAGGGTTCAAGCGATTCTCCTGCCTCAG
CCTCCTAAGTAGCTGGGATTACAGGCACCTGCCGTCATGCCTGGCTAGTTTTTGTATTTTTGGTGGAGACAGGGTTTCACCATGTTTGCC
AAACGACTCAAACTCCTGATCTCAAGTGATCTGCCCACCCAGGCCTCTACAGTGTTTTTGACATACCCTGACCATCACTTTTCTGAAATG
GAAACTCTGGGCATTTTTTTTTTAAAGCAATCCTTGCTTTTTTGTGAGTTTGCAGACTTTCAGCATCTTCCAATTGCTGTATTTACAATT
TTGGCCTCAAAAAGTATTATTTGGGTTTTGAGTCCCAAAAATAATAGTAGATACTGCTCAATGACTGGCTATACATGGTAGCTTCTCCTG
GAGTGAGGAAGGCATTCAAATGGCTGGGCGCGGTAGCTGGCACCTGTAATCCCAACACTTTCGGAGGCCAAGGCAGGCAGATCATGAGGT
CAGGAGTTCAAGACCAGGCTGACCAACGTGGTGAAACCTCCTCTTTTCTAAAAATACAAAAATTAGCTGGGCGTGGTGGCGCACCGCCTG
TAATCTCAGCTACTGAGAGAATCGCTTGAACCTGGGAGGTGGAGTTTGCAGCGAGTCGAGATTGCACCATTGTACTCCATCCAGCCTGGG
CAACGGAGCAAGATTCCGTTCCCGCCCCCGCCCCAAAAAAAGGCATTGAAGTTAAGATAGACTATATAGTTAGATCCTGGACACACACAT
GGATTTTGAGGAATGATGTGAGTTTGTTTATGTATGTACATTTTAGCAGTTAACAGATTTGGAGTAAATTGAATATTTATAAAACAACAG
TAATTGCCATGTAGGTTTACTGTCATAGTGGAAGATGATTAAGTTGATGGTACCTACAGGTATTTTGCTATGAAAATGTTTTGACAAACA
GGATGATCGTGTAATTTATGTTCCAAGCTCTAGTTTGAGAATGGAAGAATGTGGTAAATTTTTGCCAACTGAACAGGCATAAAGCGCTGA
TAATAAGGGACTTGGCCTTAAGGTAGGAGGTTGTTAGCATTTCTTTCTAAACGTGTAAGAGTTTATTTAGGTGACACCCAGCGTTTTGGA
AAAATGGGTGTTTGTTTAGAACAATAATTTGGAGGGAAGTGGACTAAACAGGGTTTTTAGATTAAGGTTTGTGTTTATGTATCTGTATCT
GCAAATACTCAGCCATAAATGTTTCTACCTGTAAGTTGGGTATAATACAAGCTCCACTTGGTATCAAAAAGGACTACCCTTAGTGTCTTC
CATGACTAGTTATGGAATGTACCAGACCTAGAGAGGAGTTGTTCTAACCTGGAGCTTTTGAAAATGTTTCCGGTCCATACCCTAGACCAA
TTAAGTCAGACTGCAGAATAGGACTCAGACATCAGAATTGTGAAGCTCCCAGGAGATGTCAAGGTATACCCAAGACTGAGAACCAGTACC
CTGTCTAGACTGAACCAGGCTTGGTTTTAGAAGTATTAAATCTCGCCTGGGTACGGTGGCTCACACCTATAATCCCAGCACTTTGGGAGG
CTGAGGTGGGTGGATCATCTGAGGTCAGGAGAGTGAGACCAGCCTGTCCAACATGTTGAAACCCCATCTCTACTATACAAAATTAGCCAG
GCATGGTGGTGCATGCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCCGGAGATGGAGGTTGCAGTGAGCTG
AGGTCGCACGATTGTGCTCCAGCCTGGGCAACCAGTGAAACTCTGGGGGGAAAGAAAAAAAATGTATTAAATCTCTAGTTTTAGAGAGTT
ACACCATAACATCCCTGAGTATGGTCAATTTCAAGTCAGCTTTAGTGTGACAAGCCCCTAGGCCCACCATTTATGTCTTTATATATTATG
GCAATATATGATCCTTATATATTAACCACTAATCGCTGCTGTTTTTGAATGTTATCTTTTCTGAGGCAGTCTTGCTCTGTCACACAGGCT
GGAGTGCAGTAACACCACTGAAGCTCACTGTAACTTTGAACTGCTGGACTTGGAATCCTCCTGCTGTGGCCTTCAAAGGGCTGCAATTAC

>78091_78091_5_RPS6-RPL23_RPS6_chr9_19378366_ENST00000380394_RPL23_chr17_37009358_ENST00000479035_length(amino acids)=301AA_BP=165
MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTG
ERKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGRGGSSGAKFRISLG
LPVGAVINCADNTGAKNLYIISVKGIKGRLNRLPAAGVGDMVMATVKKGKPELRKKVHPAVVIRQRKSYRRKDGVFLYFEDNAGVIVNNK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RPS6-RPL23


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RPS6-RPL23


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RPS6-RPL23


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource