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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RPTOR-ANKFN1 (FusionGDB2 ID:78217)

Fusion Gene Summary for RPTOR-ANKFN1

check button Fusion gene summary
Fusion gene informationFusion gene name: RPTOR-ANKFN1
Fusion gene ID: 78217
HgeneTgene
Gene symbol

RPTOR

ANKFN1

Gene ID

57521

162282

Gene nameregulatory associated protein of MTOR complex 1ankyrin repeat and fibronectin type III domain containing 1
SynonymsKOG1|Mip1-
Cytomap

17q25.3

17q22

Type of geneprotein-codingprotein-coding
Descriptionregulatory-associated protein of mTORp150 target of rapamycin (TOR)-scaffold protein containing WD-repeatsraptorankyrin repeat and fibronectin type-III domain-containing protein 1
Modification date2020031320200313
UniProtAcc.

Q8N957

Ensembl transtripts involved in fusion geneENST00000306801, ENST00000544334, 
ENST00000570891, ENST00000537330, 
ENST00000575542, 		ENST00000574292, 
ENST00000318698, ENST00000566473, 
Fusion gene scores* DoF score26 X 20 X 11=572017 X 16 X 6=1632
# samples 2719
** MAII scorelog2(27/5720*10)=-4.40498383461492
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1632*10)=-3.10256973364055
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPTOR [Title/Abstract] AND ANKFN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRPTOR(78519591)-ANKFN1(54403582), # samples:1
RPTOR(78519591)-ANKFN1(54305278), # samples:1
Anticipated loss of major functional domain due to fusion event.RPTOR-ANKFN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPTOR

GO:0031929

TOR signaling

20381137

HgeneRPTOR

GO:0032008

positive regulation of TOR signaling

12150926|18439900

HgeneRPTOR

GO:0071233

cellular response to leucine

22424946

HgeneRPTOR

GO:0071902

positive regulation of protein serine/threonine kinase activity

12150926


check buttonFusion gene breakpoints across RPTOR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ANKFN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A12M-01ARPTORchr17

78519591

-ANKFN1chr17

54305278

+
ChimerDB4BRCATCGA-C8-A12M-01ARPTORchr17

78519591

+ANKFN1chr17

54403582

+


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Fusion Gene ORF analysis for RPTOR-ANKFN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000306801ENST00000574292RPTORchr17

78519591

-ANKFN1chr17

54305278

+
5CDS-3UTRENST00000544334ENST00000574292RPTORchr17

78519591

-ANKFN1chr17

54305278

+
5CDS-3UTRENST00000570891ENST00000574292RPTORchr17

78519591

-ANKFN1chr17

54305278

+
5CDS-intronENST00000306801ENST00000574292RPTORchr17

78519591

+ANKFN1chr17

54403582

+
5CDS-intronENST00000544334ENST00000574292RPTORchr17

78519591

+ANKFN1chr17

54403582

+
5CDS-intronENST00000570891ENST00000574292RPTORchr17

78519591

+ANKFN1chr17

54403582

+
5UTR-3CDSENST00000537330ENST00000318698RPTORchr17

78519591

-ANKFN1chr17

54305278

+
5UTR-3CDSENST00000537330ENST00000318698RPTORchr17

78519591

+ANKFN1chr17

54403582

+
5UTR-3CDSENST00000537330ENST00000566473RPTORchr17

78519591

-ANKFN1chr17

54305278

+
5UTR-3CDSENST00000537330ENST00000566473RPTORchr17

78519591

+ANKFN1chr17

54403582

+
5UTR-3UTRENST00000537330ENST00000574292RPTORchr17

78519591

-ANKFN1chr17

54305278

+
5UTR-intronENST00000537330ENST00000574292RPTORchr17

78519591

+ANKFN1chr17

54403582

+
Frame-shiftENST00000306801ENST00000318698RPTORchr17

78519591

+ANKFN1chr17

54403582

+
Frame-shiftENST00000306801ENST00000566473RPTORchr17

78519591

+ANKFN1chr17

54403582

+
Frame-shiftENST00000544334ENST00000318698RPTORchr17

78519591

+ANKFN1chr17

54403582

+
Frame-shiftENST00000544334ENST00000566473RPTORchr17

78519591

+ANKFN1chr17

54403582

+
Frame-shiftENST00000570891ENST00000318698RPTORchr17

78519591

+ANKFN1chr17

54403582

+
Frame-shiftENST00000570891ENST00000566473RPTORchr17

78519591

+ANKFN1chr17

54403582

+
In-frameENST00000306801ENST00000318698RPTORchr17

78519591

-ANKFN1chr17

54305278

+
In-frameENST00000306801ENST00000566473RPTORchr17

78519591

-ANKFN1chr17

54305278

+
In-frameENST00000544334ENST00000318698RPTORchr17

78519591

-ANKFN1chr17

54305278

+
In-frameENST00000544334ENST00000566473RPTORchr17

78519591

-ANKFN1chr17

54305278

+
In-frameENST00000570891ENST00000318698RPTORchr17

78519591

-ANKFN1chr17

54305278

+
In-frameENST00000570891ENST00000566473RPTORchr17

78519591

-ANKFN1chr17

54305278

+
intron-3CDSENST00000575542ENST00000318698RPTORchr17

78519591

-ANKFN1chr17

54305278

+
intron-3CDSENST00000575542ENST00000318698RPTORchr17

78519591

+ANKFN1chr17

54403582

+
intron-3CDSENST00000575542ENST00000566473RPTORchr17

78519591

-ANKFN1chr17

54305278

+
intron-3CDSENST00000575542ENST00000566473RPTORchr17

78519591

+ANKFN1chr17

54403582

+
intron-3UTRENST00000575542ENST00000574292RPTORchr17

78519591

-ANKFN1chr17

54305278

+
intron-intronENST00000575542ENST00000574292RPTORchr17

78519591

+ANKFN1chr17

54403582

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000570891RPTORchr1778519591-ENST00000318698ANKFN1chr1754305278+32859156993185828
ENST00000570891RPTORchr1778519591-ENST00000566473ANKFN1chr1754305278+473491569943431214
ENST00000306801RPTORchr1778519591-ENST00000318698ANKFN1chr1754305278+28945243082794828
ENST00000306801RPTORchr1778519591-ENST00000566473ANKFN1chr1754305278+434352430839521214
ENST00000544334RPTORchr1778519591-ENST00000318698ANKFN1chr1754305278+26943241082594828
ENST00000544334RPTORchr1778519591-ENST00000566473ANKFN1chr1754305278+414332410837521214

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000570891ENST00000318698RPTORchr1778519591-ANKFN1chr1754305278+0.0028664690.9971335
ENST00000570891ENST00000566473RPTORchr1778519591-ANKFN1chr1754305278+0.0025583920.99744165
ENST00000306801ENST00000318698RPTORchr1778519591-ANKFN1chr1754305278+0.0021551690.9978448
ENST00000306801ENST00000566473RPTORchr1778519591-ANKFN1chr1754305278+0.0015134520.9984865
ENST00000544334ENST00000318698RPTORchr1778519591-ANKFN1chr1754305278+0.0025073580.9974927
ENST00000544334ENST00000566473RPTORchr1778519591-ANKFN1chr1754305278+0.0012874220.99871254

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Fusion Genomic Features for RPTOR-ANKFN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RPTORchr1778519591+ANKFN1chr1754403581+0.0003859220.99961406
RPTORchr1778519591+ANKFN1chr1754403581+0.0003859220.99961406

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for RPTOR-ANKFN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:78519591/chr17:54403582)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ANKFN1

Q8N957

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANKFN1chr17:78519591chr17:54305278ENST00000318698017205_2367764.0Coiled coilOntology_term=ECO:0000255
TgeneANKFN1chr17:78519591chr17:54305278ENST00000318698017273_3697764.0DomainFibronectin type-III
TgeneANKFN1chr17:78519591chr17:54305278ENST00000318698017136_1657764.0RepeatNote=ANK 1
TgeneANKFN1chr17:78519591chr17:54305278ENST00000318698017173_2027764.0RepeatNote=ANK 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRPTORchr17:78519591chr17:54305278ENST00000306801-134881_887541336.0Compositional biasNote=Poly-Ser
HgeneRPTORchr17:78519591chr17:54305278ENST00000570891-19881_88754380.0Compositional biasNote=Poly-Ser
HgeneRPTORchr17:78519591chr17:54305278ENST00000306801-1341020_1061541336.0RepeatNote=WD 1
HgeneRPTORchr17:78519591chr17:54305278ENST00000306801-1341065_1106541336.0RepeatNote=WD 2
HgeneRPTORchr17:78519591chr17:54305278ENST00000306801-1341121_1160541336.0RepeatNote=WD 3
HgeneRPTORchr17:78519591chr17:54305278ENST00000306801-1341164_1203541336.0RepeatNote=WD 4
HgeneRPTORchr17:78519591chr17:54305278ENST00000306801-1341209_1249541336.0RepeatNote=WD 5
HgeneRPTORchr17:78519591chr17:54305278ENST00000306801-1341251_1291541336.0RepeatNote=WD 6
HgeneRPTORchr17:78519591chr17:54305278ENST00000306801-1341299_1335541336.0RepeatNote=WD 7
HgeneRPTORchr17:78519591chr17:54305278ENST00000570891-191020_106154380.0RepeatNote=WD 1
HgeneRPTORchr17:78519591chr17:54305278ENST00000570891-191065_110654380.0RepeatNote=WD 2
HgeneRPTORchr17:78519591chr17:54305278ENST00000570891-191121_116054380.0RepeatNote=WD 3
HgeneRPTORchr17:78519591chr17:54305278ENST00000570891-191164_120354380.0RepeatNote=WD 4
HgeneRPTORchr17:78519591chr17:54305278ENST00000570891-191209_124954380.0RepeatNote=WD 5
HgeneRPTORchr17:78519591chr17:54305278ENST00000570891-191251_129154380.0RepeatNote=WD 6
HgeneRPTORchr17:78519591chr17:54305278ENST00000570891-191299_133554380.0RepeatNote=WD 7


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Fusion Gene Sequence for RPTOR-ANKFN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>78217_78217_1_RPTOR-ANKFN1_RPTOR_chr17_78519591_ENST00000306801_ANKFN1_chr17_54305278_ENST00000318698_length(transcript)=2894nt_BP=524nt
GAGAGCAGGGTCATCGTGAGGCCTGAAGTCTCTTACGCTTTTGGCAGCTCCCCTCGCAGCCCCTCTGGAAACGTACAGCCTCAGGAGCAG
CCAGTGGCTTGGGACCTGGGGTGGTGTGTGTCTGCGGAGCTTCTTGGGCTGCCCCATTTCCTAGCGGCCCCCACCTCCCCACTTCCCGCT
CAGAGTTAGAGATAAGGATCTCAGACTTTTGCCTGAGTAAGGGTCTCCGCACTCTTTATCCATTTGGTTTTCGATTTCCCGTTTTTGTTT
CTTATTTCACCAATTCTGGTACACGCTAGTTTTTAAGGCTGGAGGTTCTCGAGCGCTTGCTGCCAAGGACTCCCCCACCCCCTCCCCCAC
TGATGGAGTCCGAAATGCTGCAATCGCCTCTTCTGGGCCTGGGGGAGGAAGATGAGGCTGATCTTACAGACTGGAACCTACCTTTGGCTT
TTATGAAAAAGAGGCACTGTGAGAAAATTGAAGGCTCCAAATCCTTAGCTCAGAGCTGGAGGATGAAGGATCGGAGGCTACTCTTTAAAG
ACAGGCATTTTACTTGCAGCAAAATAATAGGAAGGAGATTCGCTTGCTTTGCACAGAGGCTGAGCCACAGGAGAAAGCAAAGCCAATGTG
ATTTATTGAATGAAAGCACTGGACAATTACCAACAACTTGTTCCTCTGCTGCCTCGAACAGCATAAACTGGAATTGTCGTGTGAAAATGA
CGCAACAAATGCAAAATTTACATCTCTGTCAGTCAAAAAAACATAGTGCTCCCTCATCTCCCAACGCAGCCAAACGCCTGTACAGGAACC
TCTCTGAGAAACTGAAAGGGAGCCACTCTTCCTTCGATGAGGCCTATTTTAGGACAAGAACTGATCGGCTGAGTCTCAGGAAGACCTCGG
TGAATTTCCAGGGCAATGAAGCCATGTTTGAGGCAGTCGAACAGCAGGACATGGATGCTGTGCAGATCCTCCTGTATCAGTACACACCAG
AAGAACTTGACCTCAACACACCTAACAGCGAGGGCTTGACACCCCTGGATATTGCCATCATGACCAACAATGTGCCCATTGCAAGGATTC
TTCTGAGGACAGGGGCCCGAGAAAGTCCACACTTTGTCAGCCTGGAAAGCCGAGCAATGCACCTCAACACACTGGTCCAGGAAGCCCAGG
AGAGGGTGAGTGAACTGTCTGCCCAGGTGGAGAATGAAGGATTCACTCTGGACAACACAGAGAAAGAGAAGCAGCTGAAAGCTTGGGAGT
GGAGGTATCGGCTCTACAGACGCATGAAAACAGGCTTTGAGCATGCCAGAGCCCCTGAGATGCCAACCAATGTCTGTCTCATGGTAACCA
GCAGCACATCACTCACTGTCAGCTTCCAAGAGCCTCTTAGCGTCAATGCAGCTGTAGTAACCAGGTATAAAGTGGAATGGAGTATGTCCG
AAGACTTTTCTCCTTTGGCTGGAGAAATCATCATGGATAATCTGCAGACTCTGAGATGCACAATCACAGGACTTACAATGGGCCAACAGT
ATTTTGTTCAAGTCTCGGCTTACAATATGAAAGGATGGGGACCTGCTCAGACCACGACACCGGCATGTGCCTCTCCTTCTAACTGGAAAG
ACTATGACGACAGAGAGCCCAGACACAAGGGACAGAGTGAAGTTTTGGAAGGTCTGCTGCAGCAGGTCCGAGCCCTTCATCAGCATTACA
GTTGCCGGGAAAGCACAAAATTACAAACCACAGGCCGCAAGCAGTCAGTCTCAAGAAGCCTGAAACACCTGTTCCATTCCTCGAACAAGT
TTGTGAAGACCTTAAAACGGGGACTCTACATAGCCGTTATATTTTATTACAAAGACAATATCTTAGTCACCAATGAAGATCAAGTACCAA
TTGTTGAAATAGATGACTCTCACACCAGTTCTATTACACAAGATTTTCTGTGGTTCACGAAGCTGTCTTGTATGTGGGAAGATATAAGGT
GGCTGAGGCAAAGCATACCAATATCCTCATCCTCATCCACAGTGCTGCAAACTCGGCAGAAGATGCTCGCAGCAACAGCACAGCTACAGA
ATTTACTTGGGACACACAACTTGGGAAGAGTTTACTATGAGCCCATTAAAGATCGACATGGAAACATACTCATAGTCACCATCAGGGAGG
TGGAGATGCTTTATTCATTTTTTAATGGCAAATGGATGCAGATCTCAAAGCTGCAAAGCCAGAGAAAGTCTCTATCAACACCTGAGGAGC
CAACAGCTTTAGACATTCTACTGATAACCATCCAGGATATTCTATCCTATCACAAAAGGAGTCATCAGCGTCTCTTTCCTGGATTATATC
TGGGTTACCTAAAGCTCTGTAGCTCTGTGGATCAAATCAAAGTTCTTGTTACCCAAAAGTTGCCCAACATTCTCTGCCACGTGAAGATCC
GTGAAAACAATAATATTTCTAGAGAGGAATGGGAATGGATCCAAAAGCTTTCTGGCTCTGAATCTATGGAAAGTGTGGATCATACTTCTG
ACTGCCCCATGCAATTGTTCTTCTACGAGCTCCAGATGGCAGTGAAAGCTCTCCTTCAGCAGATCAATATACCTCTACACCAGGCAAGGA
ACTTCCGCCTCTACACACAGGAGGTGTTGGAAATGGGTCACAATGTGTCCTTTCTTCTCCTGCTCCCTGCCTCAGACGACGTCTGTACAG
CCCCAGGACAGAATAATCCTTACACCCCACACTCAGGGTTTCTTAACCTCCCTCTTCAGATGTTTGAACTTGGTATAGTAGCTTGTTTCA
CCTAGAAATATTAACCCAGCCTCCTTATAATAAAATCACAAAGTTATATCTGTTCCCCCTTGTCCCAGTGGAGGGTCAATAAATCACATG

>78217_78217_1_RPTOR-ANKFN1_RPTOR_chr17_78519591_ENST00000306801_ANKFN1_chr17_54305278_ENST00000318698_length(amino acids)=828AA_BP=72
MEVLERLLPRTPPPPPPLMESEMLQSPLLGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRRLLFKDRHFTCSKIIGRR
FACFAQRLSHRRKQSQCDLLNESTGQLPTTCSSAASNSINWNCRVKMTQQMQNLHLCQSKKHSAPSSPNAAKRLYRNLSEKLKGSHSSFD
EAYFRTRTDRLSLRKTSVNFQGNEAMFEAVEQQDMDAVQILLYQYTPEELDLNTPNSEGLTPLDIAIMTNNVPIARILLRTGARESPHFV
SLESRAMHLNTLVQEAQERVSELSAQVENEGFTLDNTEKEKQLKAWEWRYRLYRRMKTGFEHARAPEMPTNVCLMVTSSTSLTVSFQEPL
SVNAAVVTRYKVEWSMSEDFSPLAGEIIMDNLQTLRCTITGLTMGQQYFVQVSAYNMKGWGPAQTTTPACASPSNWKDYDDREPRHKGQS
EVLEGLLQQVRALHQHYSCRESTKLQTTGRKQSVSRSLKHLFHSSNKFVKTLKRGLYIAVIFYYKDNILVTNEDQVPIVEIDDSHTSSIT
QDFLWFTKLSCMWEDIRWLRQSIPISSSSSTVLQTRQKMLAATAQLQNLLGTHNLGRVYYEPIKDRHGNILIVTIREVEMLYSFFNGKWM
QISKLQSQRKSLSTPEEPTALDILLITIQDILSYHKRSHQRLFPGLYLGYLKLCSSVDQIKVLVTQKLPNILCHVKIRENNNISREEWEW
IQKLSGSESMESVDHTSDCPMQLFFYELQMAVKALLQQINIPLHQARNFRLYTQEVLEMGHNVSFLLLLPASDDVCTAPGQNNPYTPHSG

--------------------------------------------------------------
>78217_78217_2_RPTOR-ANKFN1_RPTOR_chr17_78519591_ENST00000306801_ANKFN1_chr17_54305278_ENST00000566473_length(transcript)=4343nt_BP=524nt
GAGAGCAGGGTCATCGTGAGGCCTGAAGTCTCTTACGCTTTTGGCAGCTCCCCTCGCAGCCCCTCTGGAAACGTACAGCCTCAGGAGCAG
CCAGTGGCTTGGGACCTGGGGTGGTGTGTGTCTGCGGAGCTTCTTGGGCTGCCCCATTTCCTAGCGGCCCCCACCTCCCCACTTCCCGCT
CAGAGTTAGAGATAAGGATCTCAGACTTTTGCCTGAGTAAGGGTCTCCGCACTCTTTATCCATTTGGTTTTCGATTTCCCGTTTTTGTTT
CTTATTTCACCAATTCTGGTACACGCTAGTTTTTAAGGCTGGAGGTTCTCGAGCGCTTGCTGCCAAGGACTCCCCCACCCCCTCCCCCAC
TGATGGAGTCCGAAATGCTGCAATCGCCTCTTCTGGGCCTGGGGGAGGAAGATGAGGCTGATCTTACAGACTGGAACCTACCTTTGGCTT
TTATGAAAAAGAGGCACTGTGAGAAAATTGAAGGCTCCAAATCCTTAGCTCAGAGCTGGAGGATGAAGGATCGGAGGCTACTCTTTAAAG
ACAGGCATTTTACTTGCAGCAAAATAATAGGAAGGAGATTCGCTTGCTTTGCACAGAGGCTGAGCCACAGGAGAAAGCAAAGCCAATGTG
ATTTATTGAATGAAAGCACTGGACAATTACCAACAACTTGTTCCTCTGCTGCCTCGAACAGCATAAACTGGAATTGTCGTGTGAAAATGA
CGCAACAAATGCAAAATTTACATCTCTGTCAGTCAAAAAAACATAGTGCTCCCTCATCTCCCAACGCAGCCAAACGCCTGTACAGGAACC
TCTCTGAGAAACTGAAAGGGAGCCACTCTTCCTTCGATGAGGCCTATTTTAGGACAAGAACTGATCGGCTGAGTCTCAGGAAGACCTCGG
TGAATTTCCAGGGCAATGAAGCCATGTTTGAGGCAGTCGAACAGCAGGACATGGATGCTGTGCAGATCCTCCTGTATCAGTACACACCAG
AAGAACTTGACCTCAACACACCTAACAGCGAGGGCTTGACACCCCTGGATATTGCCATCATGACCAACAATGTGCCCATTGCAAGGATTC
TTCTGAGGACAGGGGCCCGAGAAAGTCCACACTTTGTCAGCCTGGAAAGCCGAGCAATGCACCTCAACACACTGGTCCAGGAAGCCCAGG
AGAGGGTGAGTGAACTGTCTGCCCAGGTGGAGAATGAAGGATTCACTCTGGACAACACAGAGAAAGAGAAGCAGCTGAAAGCTTGGGAGT
GGAGGTATCGGCTCTACAGACGCATGAAAACAGGCTTTGAGCATGCCAGAGCCCCTGAGATGCCAACCAATGTCTGTCTCATGGTAACCA
GCAGCACATCACTCACTGTCAGCTTCCAAGAGCCTCTTAGCGTCAATGCAGCTGTAGTAACCAGGTATAAAGTGGAATGGAGTATGTCCG
AAGACTTTTCTCCTTTGGCTGGAGAAATCATCATGGATAATCTGCAGACTCTGAGATGCACAATCACAGGACTTACAATGGGCCAACAGT
ATTTTGTTCAAGTCTCGGCTTACAATATGAAAGGATGGGGACCTGCTCAGACCACGACACCGGCATGTGCCTCTCCTTCTAACTGGAAAG
ACTATGACGACAGAGAGCCCAGACACAAGGGACAGAGTGAAGTTTTGGAAGGTCTGCTGCAGCAGGTCCGAGCCCTTCATCAGCATTACA
GTTGCCGGGAAAGCACAAAATTACAAACCACAGGCCGCAAGCAGTCAGTCTCAAGAAGCCTGAAACACCTGTTCCATTCCTCGAACAAGT
TTGTGAAGACCTTAAAACGGGGACTCTACATAGCCGTTATATTTTATTACAAAGACAATATCTTAGTCACCAATGAAGATCAAGTACCAA
TTGTTGAAATAGATGACTCTCACACCAGTTCTATTACACAAGATTTTCTGTGGTTCACGAAGCTGTCTTGTATGTGGGAAGATATAAGGT
GGCTGAGGCAAAGCATACCAATATCCTCATCCTCATCCACAGTGCTGCAAACTCGGCAGAAGATGCTCGCAGCAACAGCACAGCTACAGA
ATTTACTTGGGACACACAACTTGGGAAGAGTTTACTATGAGCCCATTAAAGATCGACATGGAAACATACTCATAGTCACCATCAGGGAGG
TGGAGATGCTTTATTCATTTTTTAATGGCAAATGGATGCAGATCTCAAAGCTGCAAAGCCAGAGAAAGTCTCTATCAACACCTGAGGAGC
CAACAGCTTTAGACATTCTACTGATAACCATCCAGGATATTCTATCCTATCACAAAAGGAGTCATCAGCGTCTCTTTCCTGGATTATATC
TGGGTTACCTAAAGCTCTGTAGCTCTGTGGATCAAATCAAAGTTCTTGTTACCCAAAAGTTGCCCAACATTCTCTGCCACGTGAAGATCC
GTGAAAACAATAATATTTCTAGAGAGGAATGGGAATGGATCCAAAAGCTTTCTGGCTCTGAATCTATGGAAAGTGTGGATCATACTTCTG
ACTGCCCCATGCAATTGTTCTTCTACGAGCTCCAGATGGCAGTGAAAGCTCTCCTTCAGCAGATCAATATACCTCTACACCAGGCAAGGA
ACTTCCGCCTCTACACACAGGAGGTGTTGGAAATGGGTCACAATGTGTCCTTTCTTCTCCTGCTCCCTGCCTCAGACGACGTCTGTACAG
CCCCAGGACAGAATAATCCTTACACCCCACACTCAGGGTTTCTTAACCTCCCTCTTCAGATGTTTGAACTTGTTCATTTTTGCAGCTACA
GAGAGAAATTTATTAGTCTGTATTGCCGCCTTTCTGCTGTTGTGGAGCTGGATTCTCTGAACACCCAACAGTCCCTCAGGGAAGCAATCT
CAGACAGCGAGGTTGCAGCTGCCAAACAAAGACACCAGCAAGTTTTAGATTTCATTCAGCAAATAGATGAAGTCTGGCGTGAAATGAGAT
GGATCATGGATGCTCTACAGTATGCAAGATACAAACAACCAGTTTCTGGCTTGCCCATCACTAAGCTGATAGACCCCTCAGATGAGCAGA
GCCTAAAGAAGATCAATTCTACATCATCATCACATATAGACTGTCTTCCATCCCCACCCCCATCCCCAGAGATGCACAGAAGAAAGACAG
TGAGTGATTCACAGCCCTGCTCTGATGAAGAAGCCTGCTCAGAAGTCTTCCTCCCCACCAACAGTGACTACGACTCCAGCGATGCCCTGA
GCCCCAGAGACCTGGACCTGGTCTACCTATCATCTCACGACATTGCGCAGCAGACCCTTAGCGGCCTAAGCGGCAGCGCCCCCGACGTCC
TGCAAGTGCACGACGTGAAAACCCCTCTGGGGCCGGGCCAGGATCCCCAGGGCGAGGGCCCAAATCCCGATCACTCATGTGCCGAGTTTC
TCCATAGCCTGACCCTCACGGGGTTCACACCCAAGAACCACGCCAAGACTGTGTCCGGTGGGCGGCCCCCGCTAGGCTTCCTGGGAAAGC
GGAAGCCAGGCAAGCACCCCCACTATGGCGGCTTCAGCCGCCATCATCGCTGGTTGCGCATCCACAGCGAGACCCAGTCGCTATCGCTCT
CTGAGGGCATTTATACACAGCACCTGTCCCAGGCCTGTGGTCTGGCCCAGGAGCCCAAGGAGGCCAAGCGGGCCGGCCCTGCCCTTGATG
ATCCCAGGGGCCTAACTCTGGCCCACGCTGCCAGCCTTCCTGAGGAGCGGAACAGCAGTCTCCAGGACGCGAGGCCTTCCGTCCGCCGCC
TCTACGTGGAGCCCTACGCAGCGGCCGTGGTGGCCCAGGACGAAAAACCATGGGCAAGCTTGAGCCCGCCCTCTGGAGGCCGCATCACCC
TGCCCAGCCCCACTGGCCCCGATGTGAGTCAGGAGGGCCCCACCGCCTCTCCCATGTCAGAAATACTCAGCAGCATGCTTTAGGGAGGCC
CATCCCGGCTGTCCACCCCTCCATGGCTGCTACCTGCGTTTTACATCACCCTTACCCCCATCCTGCCCCACTGTGTACCCACTCATTTTC
AAGCGTTTTGAATGTTATAAATACAAAGGTTACAAGTTCAAGGTCCTCTTTTTTTGGAACAGAGTGGTGGGTGGAGGCCAGAGTTGCCAG
TGCCATTCCCACTTCAGCCTAGAAAGGGCATGGGGGAGTTGTGTCAACATGGAATACGACATACAGTGACTCAAACATGCCACCCTGTTG
GTGGCACCTATGACTGAAGCTGGCCATCCCAAAGAGAGACCCTCTGTTCTGCAGCTGGTTCTGTAATCTGACCCCTAGTTTAGGGCTCTT

>78217_78217_2_RPTOR-ANKFN1_RPTOR_chr17_78519591_ENST00000306801_ANKFN1_chr17_54305278_ENST00000566473_length(amino acids)=1214AA_BP=72
MEVLERLLPRTPPPPPPLMESEMLQSPLLGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRRLLFKDRHFTCSKIIGRR
FACFAQRLSHRRKQSQCDLLNESTGQLPTTCSSAASNSINWNCRVKMTQQMQNLHLCQSKKHSAPSSPNAAKRLYRNLSEKLKGSHSSFD
EAYFRTRTDRLSLRKTSVNFQGNEAMFEAVEQQDMDAVQILLYQYTPEELDLNTPNSEGLTPLDIAIMTNNVPIARILLRTGARESPHFV
SLESRAMHLNTLVQEAQERVSELSAQVENEGFTLDNTEKEKQLKAWEWRYRLYRRMKTGFEHARAPEMPTNVCLMVTSSTSLTVSFQEPL
SVNAAVVTRYKVEWSMSEDFSPLAGEIIMDNLQTLRCTITGLTMGQQYFVQVSAYNMKGWGPAQTTTPACASPSNWKDYDDREPRHKGQS
EVLEGLLQQVRALHQHYSCRESTKLQTTGRKQSVSRSLKHLFHSSNKFVKTLKRGLYIAVIFYYKDNILVTNEDQVPIVEIDDSHTSSIT
QDFLWFTKLSCMWEDIRWLRQSIPISSSSSTVLQTRQKMLAATAQLQNLLGTHNLGRVYYEPIKDRHGNILIVTIREVEMLYSFFNGKWM
QISKLQSQRKSLSTPEEPTALDILLITIQDILSYHKRSHQRLFPGLYLGYLKLCSSVDQIKVLVTQKLPNILCHVKIRENNNISREEWEW
IQKLSGSESMESVDHTSDCPMQLFFYELQMAVKALLQQINIPLHQARNFRLYTQEVLEMGHNVSFLLLLPASDDVCTAPGQNNPYTPHSG
FLNLPLQMFELVHFCSYREKFISLYCRLSAVVELDSLNTQQSLREAISDSEVAAAKQRHQQVLDFIQQIDEVWREMRWIMDALQYARYKQ
PVSGLPITKLIDPSDEQSLKKINSTSSSHIDCLPSPPPSPEMHRRKTVSDSQPCSDEEACSEVFLPTNSDYDSSDALSPRDLDLVYLSSH
DIAQQTLSGLSGSAPDVLQVHDVKTPLGPGQDPQGEGPNPDHSCAEFLHSLTLTGFTPKNHAKTVSGGRPPLGFLGKRKPGKHPHYGGFS
RHHRWLRIHSETQSLSLSEGIYTQHLSQACGLAQEPKEAKRAGPALDDPRGLTLAHAASLPEERNSSLQDARPSVRRLYVEPYAAAVVAQ

--------------------------------------------------------------
>78217_78217_3_RPTOR-ANKFN1_RPTOR_chr17_78519591_ENST00000544334_ANKFN1_chr17_54305278_ENST00000318698_length(transcript)=2694nt_BP=324nt
TCAGACTTTTGCCTGAGTAAGGGTCTCCGCACTCTTTATCCATTTGGTTTTCGATTTCCCGTTTTTGTTTCTTATTTCACCAATTCTGGT
ACACGCTAGTTTTTAAGGCTGGAGGTTCTCGAGCGCTTGCTGCCAAGGACTCCCCCACCCCCTCCCCCACTGATGGAGTCCGAAATGCTG
CAATCGCCTCTTCTGGGCCTGGGGGAGGAAGATGAGGCTGATCTTACAGACTGGAACCTACCTTTGGCTTTTATGAAAAAGAGGCACTGT
GAGAAAATTGAAGGCTCCAAATCCTTAGCTCAGAGCTGGAGGATGAAGGATCGGAGGCTACTCTTTAAAGACAGGCATTTTACTTGCAGC
AAAATAATAGGAAGGAGATTCGCTTGCTTTGCACAGAGGCTGAGCCACAGGAGAAAGCAAAGCCAATGTGATTTATTGAATGAAAGCACT
GGACAATTACCAACAACTTGTTCCTCTGCTGCCTCGAACAGCATAAACTGGAATTGTCGTGTGAAAATGACGCAACAAATGCAAAATTTA
CATCTCTGTCAGTCAAAAAAACATAGTGCTCCCTCATCTCCCAACGCAGCCAAACGCCTGTACAGGAACCTCTCTGAGAAACTGAAAGGG
AGCCACTCTTCCTTCGATGAGGCCTATTTTAGGACAAGAACTGATCGGCTGAGTCTCAGGAAGACCTCGGTGAATTTCCAGGGCAATGAA
GCCATGTTTGAGGCAGTCGAACAGCAGGACATGGATGCTGTGCAGATCCTCCTGTATCAGTACACACCAGAAGAACTTGACCTCAACACA
CCTAACAGCGAGGGCTTGACACCCCTGGATATTGCCATCATGACCAACAATGTGCCCATTGCAAGGATTCTTCTGAGGACAGGGGCCCGA
GAAAGTCCACACTTTGTCAGCCTGGAAAGCCGAGCAATGCACCTCAACACACTGGTCCAGGAAGCCCAGGAGAGGGTGAGTGAACTGTCT
GCCCAGGTGGAGAATGAAGGATTCACTCTGGACAACACAGAGAAAGAGAAGCAGCTGAAAGCTTGGGAGTGGAGGTATCGGCTCTACAGA
CGCATGAAAACAGGCTTTGAGCATGCCAGAGCCCCTGAGATGCCAACCAATGTCTGTCTCATGGTAACCAGCAGCACATCACTCACTGTC
AGCTTCCAAGAGCCTCTTAGCGTCAATGCAGCTGTAGTAACCAGGTATAAAGTGGAATGGAGTATGTCCGAAGACTTTTCTCCTTTGGCT
GGAGAAATCATCATGGATAATCTGCAGACTCTGAGATGCACAATCACAGGACTTACAATGGGCCAACAGTATTTTGTTCAAGTCTCGGCT
TACAATATGAAAGGATGGGGACCTGCTCAGACCACGACACCGGCATGTGCCTCTCCTTCTAACTGGAAAGACTATGACGACAGAGAGCCC
AGACACAAGGGACAGAGTGAAGTTTTGGAAGGTCTGCTGCAGCAGGTCCGAGCCCTTCATCAGCATTACAGTTGCCGGGAAAGCACAAAA
TTACAAACCACAGGCCGCAAGCAGTCAGTCTCAAGAAGCCTGAAACACCTGTTCCATTCCTCGAACAAGTTTGTGAAGACCTTAAAACGG
GGACTCTACATAGCCGTTATATTTTATTACAAAGACAATATCTTAGTCACCAATGAAGATCAAGTACCAATTGTTGAAATAGATGACTCT
CACACCAGTTCTATTACACAAGATTTTCTGTGGTTCACGAAGCTGTCTTGTATGTGGGAAGATATAAGGTGGCTGAGGCAAAGCATACCA
ATATCCTCATCCTCATCCACAGTGCTGCAAACTCGGCAGAAGATGCTCGCAGCAACAGCACAGCTACAGAATTTACTTGGGACACACAAC
TTGGGAAGAGTTTACTATGAGCCCATTAAAGATCGACATGGAAACATACTCATAGTCACCATCAGGGAGGTGGAGATGCTTTATTCATTT
TTTAATGGCAAATGGATGCAGATCTCAAAGCTGCAAAGCCAGAGAAAGTCTCTATCAACACCTGAGGAGCCAACAGCTTTAGACATTCTA
CTGATAACCATCCAGGATATTCTATCCTATCACAAAAGGAGTCATCAGCGTCTCTTTCCTGGATTATATCTGGGTTACCTAAAGCTCTGT
AGCTCTGTGGATCAAATCAAAGTTCTTGTTACCCAAAAGTTGCCCAACATTCTCTGCCACGTGAAGATCCGTGAAAACAATAATATTTCT
AGAGAGGAATGGGAATGGATCCAAAAGCTTTCTGGCTCTGAATCTATGGAAAGTGTGGATCATACTTCTGACTGCCCCATGCAATTGTTC
TTCTACGAGCTCCAGATGGCAGTGAAAGCTCTCCTTCAGCAGATCAATATACCTCTACACCAGGCAAGGAACTTCCGCCTCTACACACAG
GAGGTGTTGGAAATGGGTCACAATGTGTCCTTTCTTCTCCTGCTCCCTGCCTCAGACGACGTCTGTACAGCCCCAGGACAGAATAATCCT
TACACCCCACACTCAGGGTTTCTTAACCTCCCTCTTCAGATGTTTGAACTTGGTATAGTAGCTTGTTTCACCTAGAAATATTAACCCAGC

>78217_78217_3_RPTOR-ANKFN1_RPTOR_chr17_78519591_ENST00000544334_ANKFN1_chr17_54305278_ENST00000318698_length(amino acids)=828AA_BP=72
MEVLERLLPRTPPPPPPLMESEMLQSPLLGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRRLLFKDRHFTCSKIIGRR
FACFAQRLSHRRKQSQCDLLNESTGQLPTTCSSAASNSINWNCRVKMTQQMQNLHLCQSKKHSAPSSPNAAKRLYRNLSEKLKGSHSSFD
EAYFRTRTDRLSLRKTSVNFQGNEAMFEAVEQQDMDAVQILLYQYTPEELDLNTPNSEGLTPLDIAIMTNNVPIARILLRTGARESPHFV
SLESRAMHLNTLVQEAQERVSELSAQVENEGFTLDNTEKEKQLKAWEWRYRLYRRMKTGFEHARAPEMPTNVCLMVTSSTSLTVSFQEPL
SVNAAVVTRYKVEWSMSEDFSPLAGEIIMDNLQTLRCTITGLTMGQQYFVQVSAYNMKGWGPAQTTTPACASPSNWKDYDDREPRHKGQS
EVLEGLLQQVRALHQHYSCRESTKLQTTGRKQSVSRSLKHLFHSSNKFVKTLKRGLYIAVIFYYKDNILVTNEDQVPIVEIDDSHTSSIT
QDFLWFTKLSCMWEDIRWLRQSIPISSSSSTVLQTRQKMLAATAQLQNLLGTHNLGRVYYEPIKDRHGNILIVTIREVEMLYSFFNGKWM
QISKLQSQRKSLSTPEEPTALDILLITIQDILSYHKRSHQRLFPGLYLGYLKLCSSVDQIKVLVTQKLPNILCHVKIRENNNISREEWEW
IQKLSGSESMESVDHTSDCPMQLFFYELQMAVKALLQQINIPLHQARNFRLYTQEVLEMGHNVSFLLLLPASDDVCTAPGQNNPYTPHSG

--------------------------------------------------------------
>78217_78217_4_RPTOR-ANKFN1_RPTOR_chr17_78519591_ENST00000544334_ANKFN1_chr17_54305278_ENST00000566473_length(transcript)=4143nt_BP=324nt
TCAGACTTTTGCCTGAGTAAGGGTCTCCGCACTCTTTATCCATTTGGTTTTCGATTTCCCGTTTTTGTTTCTTATTTCACCAATTCTGGT
ACACGCTAGTTTTTAAGGCTGGAGGTTCTCGAGCGCTTGCTGCCAAGGACTCCCCCACCCCCTCCCCCACTGATGGAGTCCGAAATGCTG
CAATCGCCTCTTCTGGGCCTGGGGGAGGAAGATGAGGCTGATCTTACAGACTGGAACCTACCTTTGGCTTTTATGAAAAAGAGGCACTGT
GAGAAAATTGAAGGCTCCAAATCCTTAGCTCAGAGCTGGAGGATGAAGGATCGGAGGCTACTCTTTAAAGACAGGCATTTTACTTGCAGC
AAAATAATAGGAAGGAGATTCGCTTGCTTTGCACAGAGGCTGAGCCACAGGAGAAAGCAAAGCCAATGTGATTTATTGAATGAAAGCACT
GGACAATTACCAACAACTTGTTCCTCTGCTGCCTCGAACAGCATAAACTGGAATTGTCGTGTGAAAATGACGCAACAAATGCAAAATTTA
CATCTCTGTCAGTCAAAAAAACATAGTGCTCCCTCATCTCCCAACGCAGCCAAACGCCTGTACAGGAACCTCTCTGAGAAACTGAAAGGG
AGCCACTCTTCCTTCGATGAGGCCTATTTTAGGACAAGAACTGATCGGCTGAGTCTCAGGAAGACCTCGGTGAATTTCCAGGGCAATGAA
GCCATGTTTGAGGCAGTCGAACAGCAGGACATGGATGCTGTGCAGATCCTCCTGTATCAGTACACACCAGAAGAACTTGACCTCAACACA
CCTAACAGCGAGGGCTTGACACCCCTGGATATTGCCATCATGACCAACAATGTGCCCATTGCAAGGATTCTTCTGAGGACAGGGGCCCGA
GAAAGTCCACACTTTGTCAGCCTGGAAAGCCGAGCAATGCACCTCAACACACTGGTCCAGGAAGCCCAGGAGAGGGTGAGTGAACTGTCT
GCCCAGGTGGAGAATGAAGGATTCACTCTGGACAACACAGAGAAAGAGAAGCAGCTGAAAGCTTGGGAGTGGAGGTATCGGCTCTACAGA
CGCATGAAAACAGGCTTTGAGCATGCCAGAGCCCCTGAGATGCCAACCAATGTCTGTCTCATGGTAACCAGCAGCACATCACTCACTGTC
AGCTTCCAAGAGCCTCTTAGCGTCAATGCAGCTGTAGTAACCAGGTATAAAGTGGAATGGAGTATGTCCGAAGACTTTTCTCCTTTGGCT
GGAGAAATCATCATGGATAATCTGCAGACTCTGAGATGCACAATCACAGGACTTACAATGGGCCAACAGTATTTTGTTCAAGTCTCGGCT
TACAATATGAAAGGATGGGGACCTGCTCAGACCACGACACCGGCATGTGCCTCTCCTTCTAACTGGAAAGACTATGACGACAGAGAGCCC
AGACACAAGGGACAGAGTGAAGTTTTGGAAGGTCTGCTGCAGCAGGTCCGAGCCCTTCATCAGCATTACAGTTGCCGGGAAAGCACAAAA
TTACAAACCACAGGCCGCAAGCAGTCAGTCTCAAGAAGCCTGAAACACCTGTTCCATTCCTCGAACAAGTTTGTGAAGACCTTAAAACGG
GGACTCTACATAGCCGTTATATTTTATTACAAAGACAATATCTTAGTCACCAATGAAGATCAAGTACCAATTGTTGAAATAGATGACTCT
CACACCAGTTCTATTACACAAGATTTTCTGTGGTTCACGAAGCTGTCTTGTATGTGGGAAGATATAAGGTGGCTGAGGCAAAGCATACCA
ATATCCTCATCCTCATCCACAGTGCTGCAAACTCGGCAGAAGATGCTCGCAGCAACAGCACAGCTACAGAATTTACTTGGGACACACAAC
TTGGGAAGAGTTTACTATGAGCCCATTAAAGATCGACATGGAAACATACTCATAGTCACCATCAGGGAGGTGGAGATGCTTTATTCATTT
TTTAATGGCAAATGGATGCAGATCTCAAAGCTGCAAAGCCAGAGAAAGTCTCTATCAACACCTGAGGAGCCAACAGCTTTAGACATTCTA
CTGATAACCATCCAGGATATTCTATCCTATCACAAAAGGAGTCATCAGCGTCTCTTTCCTGGATTATATCTGGGTTACCTAAAGCTCTGT
AGCTCTGTGGATCAAATCAAAGTTCTTGTTACCCAAAAGTTGCCCAACATTCTCTGCCACGTGAAGATCCGTGAAAACAATAATATTTCT
AGAGAGGAATGGGAATGGATCCAAAAGCTTTCTGGCTCTGAATCTATGGAAAGTGTGGATCATACTTCTGACTGCCCCATGCAATTGTTC
TTCTACGAGCTCCAGATGGCAGTGAAAGCTCTCCTTCAGCAGATCAATATACCTCTACACCAGGCAAGGAACTTCCGCCTCTACACACAG
GAGGTGTTGGAAATGGGTCACAATGTGTCCTTTCTTCTCCTGCTCCCTGCCTCAGACGACGTCTGTACAGCCCCAGGACAGAATAATCCT
TACACCCCACACTCAGGGTTTCTTAACCTCCCTCTTCAGATGTTTGAACTTGTTCATTTTTGCAGCTACAGAGAGAAATTTATTAGTCTG
TATTGCCGCCTTTCTGCTGTTGTGGAGCTGGATTCTCTGAACACCCAACAGTCCCTCAGGGAAGCAATCTCAGACAGCGAGGTTGCAGCT
GCCAAACAAAGACACCAGCAAGTTTTAGATTTCATTCAGCAAATAGATGAAGTCTGGCGTGAAATGAGATGGATCATGGATGCTCTACAG
TATGCAAGATACAAACAACCAGTTTCTGGCTTGCCCATCACTAAGCTGATAGACCCCTCAGATGAGCAGAGCCTAAAGAAGATCAATTCT
ACATCATCATCACATATAGACTGTCTTCCATCCCCACCCCCATCCCCAGAGATGCACAGAAGAAAGACAGTGAGTGATTCACAGCCCTGC
TCTGATGAAGAAGCCTGCTCAGAAGTCTTCCTCCCCACCAACAGTGACTACGACTCCAGCGATGCCCTGAGCCCCAGAGACCTGGACCTG
GTCTACCTATCATCTCACGACATTGCGCAGCAGACCCTTAGCGGCCTAAGCGGCAGCGCCCCCGACGTCCTGCAAGTGCACGACGTGAAA
ACCCCTCTGGGGCCGGGCCAGGATCCCCAGGGCGAGGGCCCAAATCCCGATCACTCATGTGCCGAGTTTCTCCATAGCCTGACCCTCACG
GGGTTCACACCCAAGAACCACGCCAAGACTGTGTCCGGTGGGCGGCCCCCGCTAGGCTTCCTGGGAAAGCGGAAGCCAGGCAAGCACCCC
CACTATGGCGGCTTCAGCCGCCATCATCGCTGGTTGCGCATCCACAGCGAGACCCAGTCGCTATCGCTCTCTGAGGGCATTTATACACAG
CACCTGTCCCAGGCCTGTGGTCTGGCCCAGGAGCCCAAGGAGGCCAAGCGGGCCGGCCCTGCCCTTGATGATCCCAGGGGCCTAACTCTG
GCCCACGCTGCCAGCCTTCCTGAGGAGCGGAACAGCAGTCTCCAGGACGCGAGGCCTTCCGTCCGCCGCCTCTACGTGGAGCCCTACGCA
GCGGCCGTGGTGGCCCAGGACGAAAAACCATGGGCAAGCTTGAGCCCGCCCTCTGGAGGCCGCATCACCCTGCCCAGCCCCACTGGCCCC
GATGTGAGTCAGGAGGGCCCCACCGCCTCTCCCATGTCAGAAATACTCAGCAGCATGCTTTAGGGAGGCCCATCCCGGCTGTCCACCCCT
CCATGGCTGCTACCTGCGTTTTACATCACCCTTACCCCCATCCTGCCCCACTGTGTACCCACTCATTTTCAAGCGTTTTGAATGTTATAA
ATACAAAGGTTACAAGTTCAAGGTCCTCTTTTTTTGGAACAGAGTGGTGGGTGGAGGCCAGAGTTGCCAGTGCCATTCCCACTTCAGCCT
AGAAAGGGCATGGGGGAGTTGTGTCAACATGGAATACGACATACAGTGACTCAAACATGCCACCCTGTTGGTGGCACCTATGACTGAAGC
TGGCCATCCCAAAGAGAGACCCTCTGTTCTGCAGCTGGTTCTGTAATCTGACCCCTAGTTTAGGGCTCTTTCATGAATTTGTGATTGATG

>78217_78217_4_RPTOR-ANKFN1_RPTOR_chr17_78519591_ENST00000544334_ANKFN1_chr17_54305278_ENST00000566473_length(amino acids)=1214AA_BP=72
MEVLERLLPRTPPPPPPLMESEMLQSPLLGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRRLLFKDRHFTCSKIIGRR
FACFAQRLSHRRKQSQCDLLNESTGQLPTTCSSAASNSINWNCRVKMTQQMQNLHLCQSKKHSAPSSPNAAKRLYRNLSEKLKGSHSSFD
EAYFRTRTDRLSLRKTSVNFQGNEAMFEAVEQQDMDAVQILLYQYTPEELDLNTPNSEGLTPLDIAIMTNNVPIARILLRTGARESPHFV
SLESRAMHLNTLVQEAQERVSELSAQVENEGFTLDNTEKEKQLKAWEWRYRLYRRMKTGFEHARAPEMPTNVCLMVTSSTSLTVSFQEPL
SVNAAVVTRYKVEWSMSEDFSPLAGEIIMDNLQTLRCTITGLTMGQQYFVQVSAYNMKGWGPAQTTTPACASPSNWKDYDDREPRHKGQS
EVLEGLLQQVRALHQHYSCRESTKLQTTGRKQSVSRSLKHLFHSSNKFVKTLKRGLYIAVIFYYKDNILVTNEDQVPIVEIDDSHTSSIT
QDFLWFTKLSCMWEDIRWLRQSIPISSSSSTVLQTRQKMLAATAQLQNLLGTHNLGRVYYEPIKDRHGNILIVTIREVEMLYSFFNGKWM
QISKLQSQRKSLSTPEEPTALDILLITIQDILSYHKRSHQRLFPGLYLGYLKLCSSVDQIKVLVTQKLPNILCHVKIRENNNISREEWEW
IQKLSGSESMESVDHTSDCPMQLFFYELQMAVKALLQQINIPLHQARNFRLYTQEVLEMGHNVSFLLLLPASDDVCTAPGQNNPYTPHSG
FLNLPLQMFELVHFCSYREKFISLYCRLSAVVELDSLNTQQSLREAISDSEVAAAKQRHQQVLDFIQQIDEVWREMRWIMDALQYARYKQ
PVSGLPITKLIDPSDEQSLKKINSTSSSHIDCLPSPPPSPEMHRRKTVSDSQPCSDEEACSEVFLPTNSDYDSSDALSPRDLDLVYLSSH
DIAQQTLSGLSGSAPDVLQVHDVKTPLGPGQDPQGEGPNPDHSCAEFLHSLTLTGFTPKNHAKTVSGGRPPLGFLGKRKPGKHPHYGGFS
RHHRWLRIHSETQSLSLSEGIYTQHLSQACGLAQEPKEAKRAGPALDDPRGLTLAHAASLPEERNSSLQDARPSVRRLYVEPYAAAVVAQ

--------------------------------------------------------------
>78217_78217_5_RPTOR-ANKFN1_RPTOR_chr17_78519591_ENST00000570891_ANKFN1_chr17_54305278_ENST00000318698_length(transcript)=3285nt_BP=915nt
ATGAGTTTCACTGTAGCTCCAAACCAGAGGGCAAAGCTCCCATGACCCAATAAGCCCACATTGTCCCTTTCCTCCGTGGTTCCGTGTCGC
CCGTTTCTCAGGACTCGTTCTCAGGCAGGAGAGAGCCTCGGGGCTGAAGGCCAGGACCAGCCAGGCCGCGCGGACCTGAGGTTGAGGAAC
CGGGTGCAGGCGAGCACGATGGGCCGGTCGTGGCTCTGGTTGCAGCAGCTCAGACGAGTGCGGGACCCGCAGGGCTGAGAGTGGCTGGAG
GAGACCCAGGGCCCTTTGAACCCGATCCCTTGGCCGGAGACCTCAGCCCAGTCGGCCCAGTGGGCGAACCGGCACCAAGAGCGGCCTGCC
TGTCTTCGGAACTGCTGAGGCGGTGGAGGCCGAGAGCAGGGTCATCGTGAGGCCTGAAGTCTCTTACGCTTTTGGCAGCTCCCCTCGCAG
CCCCTCTGGAAACGTACAGCCTCAGGAGCAGCCAGTGGCTTGGGACCTGGGGTGGTGTGTGTCTGCGGAGCTTCTTGGGCTGCCCCATTT
CCTAGCGGCCCCCACCTCCCCACTTCCCGCTCAGAGTTAGAGATAAGGATCTCAGACTTTTGCCTGAGTAAGGGTCTCCGCACTCTTTAT
CCATTTGGTTTTCGATTTCCCGTTTTTGTTTCTTATTTCACCAATTCTGGTACACGCTAGTTTTTAAGGCTGGAGGTTCTCGAGCGCTTG
CTGCCAAGGACTCCCCCACCCCCTCCCCCACTGATGGAGTCCGAAATGCTGCAATCGCCTCTTCTGGGCCTGGGGGAGGAAGATGAGGCT
GATCTTACAGACTGGAACCTACCTTTGGCTTTTATGAAAAAGAGGCACTGTGAGAAAATTGAAGGCTCCAAATCCTTAGCTCAGAGCTGG
AGGATGAAGGATCGGAGGCTACTCTTTAAAGACAGGCATTTTACTTGCAGCAAAATAATAGGAAGGAGATTCGCTTGCTTTGCACAGAGG
CTGAGCCACAGGAGAAAGCAAAGCCAATGTGATTTATTGAATGAAAGCACTGGACAATTACCAACAACTTGTTCCTCTGCTGCCTCGAAC
AGCATAAACTGGAATTGTCGTGTGAAAATGACGCAACAAATGCAAAATTTACATCTCTGTCAGTCAAAAAAACATAGTGCTCCCTCATCT
CCCAACGCAGCCAAACGCCTGTACAGGAACCTCTCTGAGAAACTGAAAGGGAGCCACTCTTCCTTCGATGAGGCCTATTTTAGGACAAGA
ACTGATCGGCTGAGTCTCAGGAAGACCTCGGTGAATTTCCAGGGCAATGAAGCCATGTTTGAGGCAGTCGAACAGCAGGACATGGATGCT
GTGCAGATCCTCCTGTATCAGTACACACCAGAAGAACTTGACCTCAACACACCTAACAGCGAGGGCTTGACACCCCTGGATATTGCCATC
ATGACCAACAATGTGCCCATTGCAAGGATTCTTCTGAGGACAGGGGCCCGAGAAAGTCCACACTTTGTCAGCCTGGAAAGCCGAGCAATG
CACCTCAACACACTGGTCCAGGAAGCCCAGGAGAGGGTGAGTGAACTGTCTGCCCAGGTGGAGAATGAAGGATTCACTCTGGACAACACA
GAGAAAGAGAAGCAGCTGAAAGCTTGGGAGTGGAGGTATCGGCTCTACAGACGCATGAAAACAGGCTTTGAGCATGCCAGAGCCCCTGAG
ATGCCAACCAATGTCTGTCTCATGGTAACCAGCAGCACATCACTCACTGTCAGCTTCCAAGAGCCTCTTAGCGTCAATGCAGCTGTAGTA
ACCAGGTATAAAGTGGAATGGAGTATGTCCGAAGACTTTTCTCCTTTGGCTGGAGAAATCATCATGGATAATCTGCAGACTCTGAGATGC
ACAATCACAGGACTTACAATGGGCCAACAGTATTTTGTTCAAGTCTCGGCTTACAATATGAAAGGATGGGGACCTGCTCAGACCACGACA
CCGGCATGTGCCTCTCCTTCTAACTGGAAAGACTATGACGACAGAGAGCCCAGACACAAGGGACAGAGTGAAGTTTTGGAAGGTCTGCTG
CAGCAGGTCCGAGCCCTTCATCAGCATTACAGTTGCCGGGAAAGCACAAAATTACAAACCACAGGCCGCAAGCAGTCAGTCTCAAGAAGC
CTGAAACACCTGTTCCATTCCTCGAACAAGTTTGTGAAGACCTTAAAACGGGGACTCTACATAGCCGTTATATTTTATTACAAAGACAAT
ATCTTAGTCACCAATGAAGATCAAGTACCAATTGTTGAAATAGATGACTCTCACACCAGTTCTATTACACAAGATTTTCTGTGGTTCACG
AAGCTGTCTTGTATGTGGGAAGATATAAGGTGGCTGAGGCAAAGCATACCAATATCCTCATCCTCATCCACAGTGCTGCAAACTCGGCAG
AAGATGCTCGCAGCAACAGCACAGCTACAGAATTTACTTGGGACACACAACTTGGGAAGAGTTTACTATGAGCCCATTAAAGATCGACAT
GGAAACATACTCATAGTCACCATCAGGGAGGTGGAGATGCTTTATTCATTTTTTAATGGCAAATGGATGCAGATCTCAAAGCTGCAAAGC
CAGAGAAAGTCTCTATCAACACCTGAGGAGCCAACAGCTTTAGACATTCTACTGATAACCATCCAGGATATTCTATCCTATCACAAAAGG
AGTCATCAGCGTCTCTTTCCTGGATTATATCTGGGTTACCTAAAGCTCTGTAGCTCTGTGGATCAAATCAAAGTTCTTGTTACCCAAAAG
TTGCCCAACATTCTCTGCCACGTGAAGATCCGTGAAAACAATAATATTTCTAGAGAGGAATGGGAATGGATCCAAAAGCTTTCTGGCTCT
GAATCTATGGAAAGTGTGGATCATACTTCTGACTGCCCCATGCAATTGTTCTTCTACGAGCTCCAGATGGCAGTGAAAGCTCTCCTTCAG
CAGATCAATATACCTCTACACCAGGCAAGGAACTTCCGCCTCTACACACAGGAGGTGTTGGAAATGGGTCACAATGTGTCCTTTCTTCTC
CTGCTCCCTGCCTCAGACGACGTCTGTACAGCCCCAGGACAGAATAATCCTTACACCCCACACTCAGGGTTTCTTAACCTCCCTCTTCAG
ATGTTTGAACTTGGTATAGTAGCTTGTTTCACCTAGAAATATTAACCCAGCCTCCTTATAATAAAATCACAAAGTTATATCTGTTCCCCC

>78217_78217_5_RPTOR-ANKFN1_RPTOR_chr17_78519591_ENST00000570891_ANKFN1_chr17_54305278_ENST00000318698_length(amino acids)=828AA_BP=72
MEVLERLLPRTPPPPPPLMESEMLQSPLLGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRRLLFKDRHFTCSKIIGRR
FACFAQRLSHRRKQSQCDLLNESTGQLPTTCSSAASNSINWNCRVKMTQQMQNLHLCQSKKHSAPSSPNAAKRLYRNLSEKLKGSHSSFD
EAYFRTRTDRLSLRKTSVNFQGNEAMFEAVEQQDMDAVQILLYQYTPEELDLNTPNSEGLTPLDIAIMTNNVPIARILLRTGARESPHFV
SLESRAMHLNTLVQEAQERVSELSAQVENEGFTLDNTEKEKQLKAWEWRYRLYRRMKTGFEHARAPEMPTNVCLMVTSSTSLTVSFQEPL
SVNAAVVTRYKVEWSMSEDFSPLAGEIIMDNLQTLRCTITGLTMGQQYFVQVSAYNMKGWGPAQTTTPACASPSNWKDYDDREPRHKGQS
EVLEGLLQQVRALHQHYSCRESTKLQTTGRKQSVSRSLKHLFHSSNKFVKTLKRGLYIAVIFYYKDNILVTNEDQVPIVEIDDSHTSSIT
QDFLWFTKLSCMWEDIRWLRQSIPISSSSSTVLQTRQKMLAATAQLQNLLGTHNLGRVYYEPIKDRHGNILIVTIREVEMLYSFFNGKWM
QISKLQSQRKSLSTPEEPTALDILLITIQDILSYHKRSHQRLFPGLYLGYLKLCSSVDQIKVLVTQKLPNILCHVKIRENNNISREEWEW
IQKLSGSESMESVDHTSDCPMQLFFYELQMAVKALLQQINIPLHQARNFRLYTQEVLEMGHNVSFLLLLPASDDVCTAPGQNNPYTPHSG

--------------------------------------------------------------
>78217_78217_6_RPTOR-ANKFN1_RPTOR_chr17_78519591_ENST00000570891_ANKFN1_chr17_54305278_ENST00000566473_length(transcript)=4734nt_BP=915nt
ATGAGTTTCACTGTAGCTCCAAACCAGAGGGCAAAGCTCCCATGACCCAATAAGCCCACATTGTCCCTTTCCTCCGTGGTTCCGTGTCGC
CCGTTTCTCAGGACTCGTTCTCAGGCAGGAGAGAGCCTCGGGGCTGAAGGCCAGGACCAGCCAGGCCGCGCGGACCTGAGGTTGAGGAAC
CGGGTGCAGGCGAGCACGATGGGCCGGTCGTGGCTCTGGTTGCAGCAGCTCAGACGAGTGCGGGACCCGCAGGGCTGAGAGTGGCTGGAG
GAGACCCAGGGCCCTTTGAACCCGATCCCTTGGCCGGAGACCTCAGCCCAGTCGGCCCAGTGGGCGAACCGGCACCAAGAGCGGCCTGCC
TGTCTTCGGAACTGCTGAGGCGGTGGAGGCCGAGAGCAGGGTCATCGTGAGGCCTGAAGTCTCTTACGCTTTTGGCAGCTCCCCTCGCAG
CCCCTCTGGAAACGTACAGCCTCAGGAGCAGCCAGTGGCTTGGGACCTGGGGTGGTGTGTGTCTGCGGAGCTTCTTGGGCTGCCCCATTT
CCTAGCGGCCCCCACCTCCCCACTTCCCGCTCAGAGTTAGAGATAAGGATCTCAGACTTTTGCCTGAGTAAGGGTCTCCGCACTCTTTAT
CCATTTGGTTTTCGATTTCCCGTTTTTGTTTCTTATTTCACCAATTCTGGTACACGCTAGTTTTTAAGGCTGGAGGTTCTCGAGCGCTTG
CTGCCAAGGACTCCCCCACCCCCTCCCCCACTGATGGAGTCCGAAATGCTGCAATCGCCTCTTCTGGGCCTGGGGGAGGAAGATGAGGCT
GATCTTACAGACTGGAACCTACCTTTGGCTTTTATGAAAAAGAGGCACTGTGAGAAAATTGAAGGCTCCAAATCCTTAGCTCAGAGCTGG
AGGATGAAGGATCGGAGGCTACTCTTTAAAGACAGGCATTTTACTTGCAGCAAAATAATAGGAAGGAGATTCGCTTGCTTTGCACAGAGG
CTGAGCCACAGGAGAAAGCAAAGCCAATGTGATTTATTGAATGAAAGCACTGGACAATTACCAACAACTTGTTCCTCTGCTGCCTCGAAC
AGCATAAACTGGAATTGTCGTGTGAAAATGACGCAACAAATGCAAAATTTACATCTCTGTCAGTCAAAAAAACATAGTGCTCCCTCATCT
CCCAACGCAGCCAAACGCCTGTACAGGAACCTCTCTGAGAAACTGAAAGGGAGCCACTCTTCCTTCGATGAGGCCTATTTTAGGACAAGA
ACTGATCGGCTGAGTCTCAGGAAGACCTCGGTGAATTTCCAGGGCAATGAAGCCATGTTTGAGGCAGTCGAACAGCAGGACATGGATGCT
GTGCAGATCCTCCTGTATCAGTACACACCAGAAGAACTTGACCTCAACACACCTAACAGCGAGGGCTTGACACCCCTGGATATTGCCATC
ATGACCAACAATGTGCCCATTGCAAGGATTCTTCTGAGGACAGGGGCCCGAGAAAGTCCACACTTTGTCAGCCTGGAAAGCCGAGCAATG
CACCTCAACACACTGGTCCAGGAAGCCCAGGAGAGGGTGAGTGAACTGTCTGCCCAGGTGGAGAATGAAGGATTCACTCTGGACAACACA
GAGAAAGAGAAGCAGCTGAAAGCTTGGGAGTGGAGGTATCGGCTCTACAGACGCATGAAAACAGGCTTTGAGCATGCCAGAGCCCCTGAG
ATGCCAACCAATGTCTGTCTCATGGTAACCAGCAGCACATCACTCACTGTCAGCTTCCAAGAGCCTCTTAGCGTCAATGCAGCTGTAGTA
ACCAGGTATAAAGTGGAATGGAGTATGTCCGAAGACTTTTCTCCTTTGGCTGGAGAAATCATCATGGATAATCTGCAGACTCTGAGATGC
ACAATCACAGGACTTACAATGGGCCAACAGTATTTTGTTCAAGTCTCGGCTTACAATATGAAAGGATGGGGACCTGCTCAGACCACGACA
CCGGCATGTGCCTCTCCTTCTAACTGGAAAGACTATGACGACAGAGAGCCCAGACACAAGGGACAGAGTGAAGTTTTGGAAGGTCTGCTG
CAGCAGGTCCGAGCCCTTCATCAGCATTACAGTTGCCGGGAAAGCACAAAATTACAAACCACAGGCCGCAAGCAGTCAGTCTCAAGAAGC
CTGAAACACCTGTTCCATTCCTCGAACAAGTTTGTGAAGACCTTAAAACGGGGACTCTACATAGCCGTTATATTTTATTACAAAGACAAT
ATCTTAGTCACCAATGAAGATCAAGTACCAATTGTTGAAATAGATGACTCTCACACCAGTTCTATTACACAAGATTTTCTGTGGTTCACG
AAGCTGTCTTGTATGTGGGAAGATATAAGGTGGCTGAGGCAAAGCATACCAATATCCTCATCCTCATCCACAGTGCTGCAAACTCGGCAG
AAGATGCTCGCAGCAACAGCACAGCTACAGAATTTACTTGGGACACACAACTTGGGAAGAGTTTACTATGAGCCCATTAAAGATCGACAT
GGAAACATACTCATAGTCACCATCAGGGAGGTGGAGATGCTTTATTCATTTTTTAATGGCAAATGGATGCAGATCTCAAAGCTGCAAAGC
CAGAGAAAGTCTCTATCAACACCTGAGGAGCCAACAGCTTTAGACATTCTACTGATAACCATCCAGGATATTCTATCCTATCACAAAAGG
AGTCATCAGCGTCTCTTTCCTGGATTATATCTGGGTTACCTAAAGCTCTGTAGCTCTGTGGATCAAATCAAAGTTCTTGTTACCCAAAAG
TTGCCCAACATTCTCTGCCACGTGAAGATCCGTGAAAACAATAATATTTCTAGAGAGGAATGGGAATGGATCCAAAAGCTTTCTGGCTCT
GAATCTATGGAAAGTGTGGATCATACTTCTGACTGCCCCATGCAATTGTTCTTCTACGAGCTCCAGATGGCAGTGAAAGCTCTCCTTCAG
CAGATCAATATACCTCTACACCAGGCAAGGAACTTCCGCCTCTACACACAGGAGGTGTTGGAAATGGGTCACAATGTGTCCTTTCTTCTC
CTGCTCCCTGCCTCAGACGACGTCTGTACAGCCCCAGGACAGAATAATCCTTACACCCCACACTCAGGGTTTCTTAACCTCCCTCTTCAG
ATGTTTGAACTTGTTCATTTTTGCAGCTACAGAGAGAAATTTATTAGTCTGTATTGCCGCCTTTCTGCTGTTGTGGAGCTGGATTCTCTG
AACACCCAACAGTCCCTCAGGGAAGCAATCTCAGACAGCGAGGTTGCAGCTGCCAAACAAAGACACCAGCAAGTTTTAGATTTCATTCAG
CAAATAGATGAAGTCTGGCGTGAAATGAGATGGATCATGGATGCTCTACAGTATGCAAGATACAAACAACCAGTTTCTGGCTTGCCCATC
ACTAAGCTGATAGACCCCTCAGATGAGCAGAGCCTAAAGAAGATCAATTCTACATCATCATCACATATAGACTGTCTTCCATCCCCACCC
CCATCCCCAGAGATGCACAGAAGAAAGACAGTGAGTGATTCACAGCCCTGCTCTGATGAAGAAGCCTGCTCAGAAGTCTTCCTCCCCACC
AACAGTGACTACGACTCCAGCGATGCCCTGAGCCCCAGAGACCTGGACCTGGTCTACCTATCATCTCACGACATTGCGCAGCAGACCCTT
AGCGGCCTAAGCGGCAGCGCCCCCGACGTCCTGCAAGTGCACGACGTGAAAACCCCTCTGGGGCCGGGCCAGGATCCCCAGGGCGAGGGC
CCAAATCCCGATCACTCATGTGCCGAGTTTCTCCATAGCCTGACCCTCACGGGGTTCACACCCAAGAACCACGCCAAGACTGTGTCCGGT
GGGCGGCCCCCGCTAGGCTTCCTGGGAAAGCGGAAGCCAGGCAAGCACCCCCACTATGGCGGCTTCAGCCGCCATCATCGCTGGTTGCGC
ATCCACAGCGAGACCCAGTCGCTATCGCTCTCTGAGGGCATTTATACACAGCACCTGTCCCAGGCCTGTGGTCTGGCCCAGGAGCCCAAG
GAGGCCAAGCGGGCCGGCCCTGCCCTTGATGATCCCAGGGGCCTAACTCTGGCCCACGCTGCCAGCCTTCCTGAGGAGCGGAACAGCAGT
CTCCAGGACGCGAGGCCTTCCGTCCGCCGCCTCTACGTGGAGCCCTACGCAGCGGCCGTGGTGGCCCAGGACGAAAAACCATGGGCAAGC
TTGAGCCCGCCCTCTGGAGGCCGCATCACCCTGCCCAGCCCCACTGGCCCCGATGTGAGTCAGGAGGGCCCCACCGCCTCTCCCATGTCA
GAAATACTCAGCAGCATGCTTTAGGGAGGCCCATCCCGGCTGTCCACCCCTCCATGGCTGCTACCTGCGTTTTACATCACCCTTACCCCC
ATCCTGCCCCACTGTGTACCCACTCATTTTCAAGCGTTTTGAATGTTATAAATACAAAGGTTACAAGTTCAAGGTCCTCTTTTTTTGGAA
CAGAGTGGTGGGTGGAGGCCAGAGTTGCCAGTGCCATTCCCACTTCAGCCTAGAAAGGGCATGGGGGAGTTGTGTCAACATGGAATACGA
CATACAGTGACTCAAACATGCCACCCTGTTGGTGGCACCTATGACTGAAGCTGGCCATCCCAAAGAGAGACCCTCTGTTCTGCAGCTGGT

>78217_78217_6_RPTOR-ANKFN1_RPTOR_chr17_78519591_ENST00000570891_ANKFN1_chr17_54305278_ENST00000566473_length(amino acids)=1214AA_BP=72
MEVLERLLPRTPPPPPPLMESEMLQSPLLGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRRLLFKDRHFTCSKIIGRR
FACFAQRLSHRRKQSQCDLLNESTGQLPTTCSSAASNSINWNCRVKMTQQMQNLHLCQSKKHSAPSSPNAAKRLYRNLSEKLKGSHSSFD
EAYFRTRTDRLSLRKTSVNFQGNEAMFEAVEQQDMDAVQILLYQYTPEELDLNTPNSEGLTPLDIAIMTNNVPIARILLRTGARESPHFV
SLESRAMHLNTLVQEAQERVSELSAQVENEGFTLDNTEKEKQLKAWEWRYRLYRRMKTGFEHARAPEMPTNVCLMVTSSTSLTVSFQEPL
SVNAAVVTRYKVEWSMSEDFSPLAGEIIMDNLQTLRCTITGLTMGQQYFVQVSAYNMKGWGPAQTTTPACASPSNWKDYDDREPRHKGQS
EVLEGLLQQVRALHQHYSCRESTKLQTTGRKQSVSRSLKHLFHSSNKFVKTLKRGLYIAVIFYYKDNILVTNEDQVPIVEIDDSHTSSIT
QDFLWFTKLSCMWEDIRWLRQSIPISSSSSTVLQTRQKMLAATAQLQNLLGTHNLGRVYYEPIKDRHGNILIVTIREVEMLYSFFNGKWM
QISKLQSQRKSLSTPEEPTALDILLITIQDILSYHKRSHQRLFPGLYLGYLKLCSSVDQIKVLVTQKLPNILCHVKIRENNNISREEWEW
IQKLSGSESMESVDHTSDCPMQLFFYELQMAVKALLQQINIPLHQARNFRLYTQEVLEMGHNVSFLLLLPASDDVCTAPGQNNPYTPHSG
FLNLPLQMFELVHFCSYREKFISLYCRLSAVVELDSLNTQQSLREAISDSEVAAAKQRHQQVLDFIQQIDEVWREMRWIMDALQYARYKQ
PVSGLPITKLIDPSDEQSLKKINSTSSSHIDCLPSPPPSPEMHRRKTVSDSQPCSDEEACSEVFLPTNSDYDSSDALSPRDLDLVYLSSH
DIAQQTLSGLSGSAPDVLQVHDVKTPLGPGQDPQGEGPNPDHSCAEFLHSLTLTGFTPKNHAKTVSGGRPPLGFLGKRKPGKHPHYGGFS
RHHRWLRIHSETQSLSLSEGIYTQHLSQACGLAQEPKEAKRAGPALDDPRGLTLAHAASLPEERNSSLQDARPSVRRLYVEPYAAAVVAQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RPTOR-ANKFN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RPTOR-ANKFN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RPTOR-ANKFN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource